ZIC4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ZIC4
Entrez Gene ID	84107
Full Name	Zic family member 4
General protein information	Preferred Names Zic family member 4 Names zinc finger protein ZIC 4 zinc family member 4 protein HZIC4 zinc finger protein of the cerebellum 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q24
Summary	This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009].
Disorder MIM:	608948

mRNA and Protein(s)

mRNA	Protein	Name
XM_011513231.1	XP_011511533.1	zinc finger protein ZIC 4 isoform X1
XM_017007314.2	XP_016862803.1	zinc finger protein ZIC 4 isoform X1
XM_017007314.1	XP_016862803.1	zinc finger protein ZIC 4 isoform X1
NM_001243256.1	NP_001230185.1	zinc finger protein ZIC 4 isoform 4
NM_001168378.1	NP_001161850.1	zinc finger protein ZIC 4 isoform 1 precursor
NM_001168379.1	NP_001161851.1	zinc finger protein ZIC 4 isoform 2
NM_032153.5	NP_115529.2	zinc finger protein ZIC 4 isoform 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	ZIC4	NP_001161850.1
Pan troglodytes (chimpanzee)	ZIC4	XP_526339.3
Mus musculus (house mouse)	Zic4	NP_033602.2
Xenopus tropicalis (tropical clawed frog)	zic4	XP_004914413.1
Macaca mulatta (Rhesus monkey)	LOC712982	XP_001110894.2
Bos taurus (cattle)	ZIC4	XP_002685060.3
Canis lupus familiaris (dog)	ZIC4	XP_005634606.1
Danio rerio (zebrafish)	zic4	NP_001070080.1
Gallus gallus (chicken)	ZIC4	XP_422698.4

Gene Ontology
Bibliography

Related articles in PubMed

Prognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas.
Paluszczak J, Wiśniewska D, Kostrzewska-Poczekaj M, Kiwerska K, Grénman R, Mielcarek-Kuchta D, Jarmuż-Szymczak M
Clinical oral investigations21(5)1777-1788(2017 Jun)

Genome-wide analysis of CpG island methylation in bladder cancer identified TBX2, TBX3, GATA2, and ZIC4 as pTa-specific prognostic markers.
Kandimalla R, van Tilborg AA, Kompier LC, Stumpel DJ, Stam RW, Bangma CH, Zwarthoff EC
European urology61(6)1245-56(2012 Jun)

Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion: Report of a new patient.
Tohyama J, Kato M, Kawasaki S, Harada N, Kawara H, Matsui T, Akasaka N, Ohashi T, Kobayashi Y, Matsumoto N
American journal of medical genetics. Part A155A(1)130-3(2011 Jan)

The ZIC gene family in development and disease.
Grinberg I, Millen KJ
Clinical genetics67(4)290-6(2005 Apr)

Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer.
Jaster JH
Neurology63(7)1339; author reply 1339(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ZIC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZIC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55961	NM_001243256.1 Latest version!	Homo sapiens Zic family member 4 (ZIC4), transcript variant 6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu94643	XM_017007314.2 Latest version!	Homo sapiens Zic family member 4 (ZIC4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu19275	NM_032153.5 Latest version!	Homo sapiens Zic family member 4 (ZIC4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OHu32164	NM_001168378.1 Latest version!	Homo sapiens Zic family member 4 (ZIC4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$258.30 $369.00
OHu32262	NM_001168379.1 Latest version!	Homo sapiens Zic family member 4 (ZIC4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu19275	XM_011513231.1 Latest version!	Homo sapiens Zic family member 4 (ZIC4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu94643	XM_017007314.1	Homo sapiens Zic family member 4 (ZIC4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZIC4 ( NM_001243256.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230185.1 Homo sapiens Zic family member 4 (ZIC4), transcript variant 6, mRNA.

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CloneID	OHu55961
Clone ID Related Accession (Same CDS sequence)	NM_001243256.1
Accession Version	NM_001243256.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564934400000
Organism	Homo sapiens(human)
Product	zinc finger protein ZIC 4 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA102161.1, DA759114.1, DA218617.1 and AK124600.1. Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.32095.1, SRR1803612.282234.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2145743, SAMEA2157437 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGATACA AGACATCCTT GGTGATGAGG AAACGATTAC GGCTTTACCG AAACACTCTT 
AAAGAGTCAA GCGAGAAGCC CTTCAGATGC GAGTTCGAGG GCTGCGAGCG GCGCTTCGCC 
AACAGCAGCG ACCGTAAGAA GCATTCGCAC GTGCACACTA GCGACAAGCC ATACACGTGC 
AAGGTGCGGG GCTGCGACAA GTGCTACACG CACCCCAGCT CGCTGCGTAA GCACATGAAG 
GTGCACGGGC GCTCGCCGCC GCCCAGCTCT GGCTACGATT CGGCTACACC GTCTGCCCTC 
GTGTCGCCCT CGTCGGACTG CGGCCACAAG TCCCAGGTGG CCTCCTCGGC GGCGGTGGCG 
GCGCGTACCG CCGACTTGAG CGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230185.1
CDS	463..849
Translation	MRYKTSLVMRKRLRLYRNTLKESSEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDSATPSALVSPSSDCGHKSQVASSAAVAARTADLSE

Target ORF information:

RefSeq Version	NM_001243256.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Zic family member 4 (ZIC4), transcript variant 6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243256.1

ORF Insert Sequence:

ATGAGATACA AGACATCCTT GGTGATGAGG AAACGATTAC GGCTTTACCG AAACACTCTT 
AAAGAGTCAA GCGAGAAGCC CTTCAGATGC GAGTTCGAGG GCTGCGAGCG GCGCTTCGCC 
AACAGCAGCG ACCGTAAGAA GCATTCGCAC GTGCACACTA GCGACAAGCC ATACACGTGC 
AAGGTGCGGG GCTGCGACAA GTGCTACACG CACCCCAGCT CGCTGCGTAA GCACATGAAG 
GTGCACGGGC GCTCGCCGCC GCCCAGCTCT GGCTACGATT CGGCTACACC GTCTGCCCTC 
GTGTCGCCCT CGTCGGACTG CGGCCACAAG TCCCAGGTGG CCTCCTCGGC GGCGGTGGCG 
GCGCGTACCG CCGACTTGAG CGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZIC4 ( XM_017007314.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016862803.1 Homo sapiens Zic family member 4 (ZIC4), transcript variant X1, mRNA.

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CloneID	OHu94643
Clone ID Related Accession (Same CDS sequence)	XM_017007314.2 , XM_017007314.1
Accession Version	XM_017007314.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	zinc finger protein ZIC 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017007314.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCCCT TCTGTAGGAA TGCAAAGTTA GGCCTCCTTT CTTTCCTGAT TTGTGCTGGA 
AGGAGCTTAT TACCTTTGGG GAAGAATGCC TTTTGGTTAG AAAGAATTGA AAATAATAAT 
ACCCTCTGGG AAAAGGCTCA AAGTCAGAAA ATGAGATACA AGACATCCTT GGTGATGAGG 
AAACGATTAC GGCTTTACCG AAACACTCTT AAAGAGTCAA GTAGCAGCTC TGGACACCAT 
GGCCCCCAGC TCACCGCCGC CTCCAGCCCC TCGGTGTTCC CGGGCCTCCA CGAGGAGCCT 
CCCCAGGCCT CCCCCAGCCG TCCTTTGAAT GGACTCCTGC GTCTGGGGCT CCCTGGAGAC 
ATGTACGCGC GGCCGGAGCC CTTCCCGCCA GGGCCTGCGG CCCGCAGCGA CGCCCTGGCA 
GCTGCCGCAG CCCTGCATGG CTACGGGGGC ATGAACCTGA CGGTGAACCT CGCTGCGCCC 
CACGGTCCTG GCGCTTTCTT CCGCTACATG CGCCAGCCCA TCAAACAGGA GCTCATCTGC 
AAGTGGCTGG CGGCCGACGG CACCGCGACC CCGAGCCTCT GCTCCAAAAC TTTCAGCACC 
ATGCACGAGC TGGTCACGCA CGTCACCGTG GAGCACGTCG GCGGCCCGGA ACAGGCCAAC 
CACATTTGCT TCTGGGAGGA GTGTCCGCGC CAGGGAAAGC CCTTCAAAGC CAAATACAAA 
CTTGTAAATC ACATCCGCGT GCACACGGGC GAGAAGCCCT TCCCTTGTCC TTTCCCGGGG 
TGTGGGAAGG TCTTTGCTAG ATCAGAAAAT CTCAAAATAC ACAAACGAAC TCACACAGCA 
GAAGCGGCAA ACAGGAGCAA ATTTCTCAGG AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016862803.1
CDS	3379..4254
Translation	MPPFCRNAKLGLLSFLICAGRSLLPLGKNAFWLERIENNNTLWEKAQSQKMRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLNGLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMRQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTAEAANRSKFLRS

Target ORF information:

RefSeq Version	XM_017007314.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Zic family member 4 (ZIC4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017007314.2

ORF Insert Sequence:

ATGCCGCCCT TCTGTAGGAA TGCAAAGTTA GGCCTCCTTT CTTTCCTGAT TTGTGCTGGA 
AGGAGCTTAT TACCTTTGGG GAAGAATGCC TTTTGGTTAG AAAGAATTGA AAATAATAAT 
ACCCTCTGGG AAAAGGCTCA AAGTCAGAAA ATGAGATACA AGACATCCTT GGTGATGAGG 
AAACGATTAC GGCTTTACCG AAACACTCTT AAAGAGTCAA GTAGCAGCTC TGGACACCAT 
GGCCCCCAGC TCACCGCCGC CTCCAGCCCC TCGGTGTTCC CGGGCCTCCA CGAGGAGCCT 
CCCCAGGCCT CCCCCAGCCG TCCTTTGAAT GGACTCCTGC GTCTGGGGCT CCCTGGAGAC 
ATGTACGCGC GGCCGGAGCC CTTCCCGCCA GGGCCTGCGG CCCGCAGCGA CGCCCTGGCA 
GCTGCCGCAG CCCTGCATGG CTACGGGGGC ATGAACCTGA CGGTGAACCT CGCTGCGCCC 
CACGGTCCTG GCGCTTTCTT CCGCTACATG CGCCAGCCCA TCAAACAGGA GCTCATCTGC 
AAGTGGCTGG CGGCCGACGG CACCGCGACC CCGAGCCTCT GCTCCAAAAC TTTCAGCACC 
ATGCACGAGC TGGTCACGCA CGTCACCGTG GAGCACGTCG GCGGCCCGGA ACAGGCCAAC 
CACATTTGCT TCTGGGAGGA GTGTCCGCGC CAGGGAAAGC CCTTCAAAGC CAAATACAAA 
CTTGTAAATC ACATCCGCGT GCACACGGGC GAGAAGCCCT TCCCTTGTCC TTTCCCGGGG 
TGTGGGAAGG TCTTTGCTAG ATCAGAAAAT CTCAAAATAC ACAAACGAAC TCACACAGCA 
GAAGCGGCAA ACAGGAGCAA ATTTCTCAGG AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZIC4 ( XM_017007314.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016862803.1 Homo sapiens Zic family member 4 (ZIC4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu94643
Clone ID Related Accession (Same CDS sequence)	XM_017007314.2 , XM_017007314.1
Accession Version	XM_017007314.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	zinc finger protein ZIC 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCCCT TCTGTAGGAA TGCAAAGTTA GGCCTCCTTT CTTTCCTGAT TTGTGCTGGA 
AGGAGCTTAT TACCTTTGGG GAAGAATGCC TTTTGGTTAG AAAGAATTGA AAATAATAAT 
ACCCTCTGGG AAAAGGCTCA AAGTCAGAAA ATGAGATACA AGACATCCTT GGTGATGAGG 
AAACGATTAC GGCTTTACCG AAACACTCTT AAAGAGTCAA GTAGCAGCTC TGGACACCAT 
GGCCCCCAGC TCACCGCCGC CTCCAGCCCC TCGGTGTTCC CGGGCCTCCA CGAGGAGCCT 
CCCCAGGCCT CCCCCAGCCG TCCTTTGAAT GGACTCCTGC GTCTGGGGCT CCCTGGAGAC 
ATGTACGCGC GGCCGGAGCC CTTCCCGCCA GGGCCTGCGG CCCGCAGCGA CGCCCTGGCA 
GCTGCCGCAG CCCTGCATGG CTACGGGGGC ATGAACCTGA CGGTGAACCT CGCTGCGCCC 
CACGGTCCTG GCGCTTTCTT CCGCTACATG CGCCAGCCCA TCAAACAGGA GCTCATCTGC 
AAGTGGCTGG CGGCCGACGG CACCGCGACC CCGAGCCTCT GCTCCAAAAC TTTCAGCACC 
ATGCACGAGC TGGTCACGCA CGTCACCGTG GAGCACGTCG GCGGCCCGGA ACAGGCCAAC 
CACATTTGCT TCTGGGAGGA GTGTCCGCGC CAGGGAAAGC CCTTCAAAGC CAAATACAAA 
CTTGTAAATC ACATCCGCGT GCACACGGGC GAGAAGCCCT TCCCTTGTCC TTTCCCGGGG 
TGTGGGAAGG TCTTTGCTAG ATCAGAAAAT CTCAAAATAC ACAAACGAAC TCACACAGCA 
GAAGCGGCAA ACAGGAGCAA ATTTCTCAGG AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016862803.1
CDS	2796..3671
Translation	MPPFCRNAKLGLLSFLICAGRSLLPLGKNAFWLERIENNNTLWEKAQSQKMRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLNGLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMRQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTAEAANRSKFLRS

Target ORF information:

RefSeq Version	XM_017007314.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Zic family member 4 (ZIC4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017007314.1

ORF Insert Sequence:

ATGCCGCCCT TCTGTAGGAA TGCAAAGTTA GGCCTCCTTT CTTTCCTGAT TTGTGCTGGA 
AGGAGCTTAT TACCTTTGGG GAAGAATGCC TTTTGGTTAG AAAGAATTGA AAATAATAAT 
ACCCTCTGGG AAAAGGCTCA AAGTCAGAAA ATGAGATACA AGACATCCTT GGTGATGAGG 
AAACGATTAC GGCTTTACCG AAACACTCTT AAAGAGTCAA GTAGCAGCTC TGGACACCAT 
GGCCCCCAGC TCACCGCCGC CTCCAGCCCC TCGGTGTTCC CGGGCCTCCA CGAGGAGCCT 
CCCCAGGCCT CCCCCAGCCG TCCTTTGAAT GGACTCCTGC GTCTGGGGCT CCCTGGAGAC 
ATGTACGCGC GGCCGGAGCC CTTCCCGCCA GGGCCTGCGG CCCGCAGCGA CGCCCTGGCA 
GCTGCCGCAG CCCTGCATGG CTACGGGGGC ATGAACCTGA CGGTGAACCT CGCTGCGCCC 
CACGGTCCTG GCGCTTTCTT CCGCTACATG CGCCAGCCCA TCAAACAGGA GCTCATCTGC 
AAGTGGCTGG CGGCCGACGG CACCGCGACC CCGAGCCTCT GCTCCAAAAC TTTCAGCACC 
ATGCACGAGC TGGTCACGCA CGTCACCGTG GAGCACGTCG GCGGCCCGGA ACAGGCCAAC 
CACATTTGCT TCTGGGAGGA GTGTCCGCGC CAGGGAAAGC CCTTCAAAGC CAAATACAAA 
CTTGTAAATC ACATCCGCGT GCACACGGGC GAGAAGCCCT TCCCTTGTCC TTTCCCGGGG 
TGTGGGAAGG TCTTTGCTAG ATCAGAAAAT CTCAAAATAC ACAAACGAAC TCACACAGCA 
GAAGCGGCAA ACAGGAGCAA ATTTCTCAGG AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZIC4 ( NM_032153.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_115529.2 Homo sapiens Zic family member 4 (ZIC4), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu19275
Clone ID Related Accession (Same CDS sequence)	XM_011513231.1 , NM_032153.5
Accession Version	NM_032153.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564934400000
Organism	Homo sapiens(human)
Product	zinc finger protein ZIC 4 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA102161.1, AK056262.1 and AK124600.1. This sequence is a reference standard in the RefSeqGene project. On Aug 6, 2011 this sequence version replaced NM_032153.4. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream, in-frame start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.212626.1, SRR1803611.148152.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465403 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGATACA AGACATCCTT GGTGATGAGG AAACGATTAC GGCTTTACCG AAACACTCTT 
AAAGAGTCAA GTAGCAGCTC TGGACACCAT GGCCCCCAGC TCACCGCCGC CTCCAGCCCC 
TCGGTGTTCC CGGGCCTCCA CGAGGAGCCT CCCCAGGCCT CCCCCAGCCG TCCTTTGAAT 
GGACTCCTGC GTCTGGGGCT CCCTGGAGAC ATGTACGCGC GGCCGGAGCC CTTCCCGCCA 
GGGCCTGCGG CCCGCAGCGA CGCCCTGGCA GCTGCCGCAG CCCTGCATGG CTACGGGGGC 
ATGAACCTGA CGGTGAACCT CGCTGCGCCC CACGGTCCTG GCGCTTTCTT CCGCTACATG 
CGCCAGCCCA TCAAACAGGA GCTCATCTGC AAGTGGCTGG CGGCCGACGG CACCGCGACC 
CCGAGCCTCT GCTCCAAAAC TTTCAGCACC ATGCACGAGC TGGTCACGCA CGTCACCGTG 
GAGCACGTCG GCGGCCCGGA ACAGGCCAAC CACATTTGCT TCTGGGAGGA GTGTCCGCGC 
CAGGGAAAGC CCTTCAAAGC CAAATACAAA CTTGTAAATC ACATCCGCGT GCACACGGGC 
GAGAAGCCCT TCCCTTGTCC TTTCCCGGGG TGTGGGAAGG TCTTTGCTAG ATCAGAAAAT 
CTCAAAATAC ACAAACGAAC TCACACAGGC GAGAAGCCCT TCAGATGCGA GTTCGAGGGC 
TGCGAGCGGC GCTTCGCCAA CAGCAGCGAC CGTAAGAAGC ATTCGCACGT GCACACTAGC 
GACAAGCCAT ACACGTGCAA GGTGCGGGGC TGCGACAAGT GCTACACGCA CCCCAGCTCG 
CTGCGTAAGC ACATGAAGGT GCACGGGCGC TCGCCGCCGC CCAGCTCTGG CTACGATTCG 
GCTACACCGT CTGCCCTCGT GTCGCCCTCG TCGGACTGCG GCCACAAGTC CCAGGTGGCC 
TCCTCGGCGG CGGTGGCGGC GCGTACCGCC GACTTGAGCG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115529.2
CDS	463..1467
Translation	MRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLNGLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMRQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDSATPSALVSPSSDCGHKSQVASSAAVAARTADLSE

Target ORF information:

RefSeq Version	NM_032153.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Zic family member 4 (ZIC4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032153.5

ORF Insert Sequence:

ATGAGATACA AGACATCCTT GGTGATGAGG AAACGATTAC GGCTTTACCG AAACACTCTT 
AAAGAGTCAA GTAGCAGCTC TGGACACCAT GGCCCCCAGC TCACCGCCGC CTCCAGCCCC 
TCGGTGTTCC CGGGCCTCCA CGAGGAGCCT CCCCAGGCCT CCCCCAGCCG TCCTTTGAAT 
GGACTCCTGC GTCTGGGGCT CCCTGGAGAC ATGTACGCGC GGCCGGAGCC CTTCCCGCCA 
GGGCCTGCGG CCCGCAGCGA CGCCCTGGCA GCTGCCGCAG CCCTGCATGG CTACGGGGGC 
ATGAACCTGA CGGTGAACCT CGCTGCGCCC CACGGTCCTG GCGCTTTCTT CCGCTACATG 
CGCCAGCCCA TCAAACAGGA GCTCATCTGC AAGTGGCTGG CGGCCGACGG CACCGCGACC 
CCGAGCCTCT GCTCCAAAAC TTTCAGCACC ATGCACGAGC TGGTCACGCA CGTCACCGTG 
GAGCACGTCG GCGGCCCGGA ACAGGCCAAC CACATTTGCT TCTGGGAGGA GTGTCCGCGC 
CAGGGAAAGC CCTTCAAAGC CAAATACAAA CTTGTAAATC ACATCCGCGT GCACACGGGC 
GAGAAGCCCT TCCCTTGTCC TTTCCCGGGG TGTGGGAAGG TCTTTGCTAG ATCAGAAAAT 
CTCAAAATAC ACAAACGAAC TCACACAGGC GAGAAGCCCT TCAGATGCGA GTTCGAGGGC 
TGCGAGCGGC GCTTCGCCAA CAGCAGCGAC CGTAAGAAGC ATTCGCACGT GCACACTAGC 
GACAAGCCAT ACACGTGCAA GGTGCGGGGC TGCGACAAGT GCTACACGCA CCCCAGCTCG 
CTGCGTAAGC ACATGAAGGT GCACGGGCGC TCGCCGCCGC CCAGCTCTGG CTACGATTCG 
GCTACACCGT CTGCCCTCGT GTCGCCCTCG TCGGACTGCG GCCACAAGTC CCAGGTGGCC 
TCCTCGGCGG CGGTGGCGGC GCGTACCGCC GACTTGAGCG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZIC4 ( NM_001168378.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001161850.1 Homo sapiens Zic family member 4 (ZIC4), transcript variant 1, mRNA.

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CloneID	OHu32164
Clone ID Related Accession (Same CDS sequence)	NM_001168378.1
Accession Version	NM_001168378.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564761600000
Organism	Homo sapiens(human)
Product	zinc finger protein ZIC 4 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK294831.1, DA066220.1 and AK124600.1. Transcript Variant: This variant (1) encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK294831.1, SRR1660809.223481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465403 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCCCT TCTGTAGGAA TGCAAAGTTA GGCCTCCTTT CTTTCCTGAT TTGTGCTGGA 
AGGAGCTTAT TACCTTTGGG GAAGAATGCC TTTTGGTTAG AAAGAATTGA AAATAATAAT 
ACCCTCTGGG AAAAGGCTCA AAGTCAGAAA ATGAGATACA AGACATCCTT GGTGATGAGG 
AAACGATTAC GGCTTTACCG AAACACTCTT AAAGAGTCAA GTAGCAGCTC TGGACACCAT 
GGCCCCCAGC TCACCGCCGC CTCCAGCCCC TCGGTGTTCC CGGGCCTCCA CGAGGAGCCT 
CCCCAGGCCT CCCCCAGCCG TCCTTTGAAT GGACTCCTGC GTCTGGGGCT CCCTGGAGAC 
ATGTACGCGC GGCCGGAGCC CTTCCCGCCA GGGCCTGCGG CCCGCAGCGA CGCCCTGGCA 
GCTGCCGCAG CCCTGCATGG CTACGGGGGC ATGAACCTGA CGGTGAACCT CGCTGCGCCC 
CACGGTCCTG GCGCTTTCTT CCGCTACATG CGCCAGCCCA TCAAACAGGA GCTCATCTGC 
AAGTGGCTGG CGGCCGACGG CACCGCGACC CCGAGCCTCT GCTCCAAAAC TTTCAGCACC 
ATGCACGAGC TGGTCACGCA CGTCACCGTG GAGCACGTCG GCGGCCCGGA ACAGGCCAAC 
CACATTTGCT TCTGGGAGGA GTGTCCGCGC CAGGGAAAGC CCTTCAAAGC CAAATACAAA 
CTTGTAAATC ACATCCGCGT GCACACGGGC GAGAAGCCCT TCCCTTGTCC TTTCCCGGGG 
TGTGGGAAGG TCTTTGCTAG ATCAGAAAAT CTCAAAATAC ACAAACGAAC TCACACAGGC 
GAGAAGCCCT TCAGATGCGA GTTCGAGGGC TGCGAGCGGC GCTTCGCCAA CAGCAGCGAC 
CGTAAGAAGC ATTCGCACGT GCACACTAGC GACAAGCCAT ACACGTGCAA GGTGCGGGGC 
TGCGACAAGT GCTACACGCA CCCCAGCTCG CTGCGTAAGC ACATGAAGGT GCACGGGCGC 
TCGCCGCCGC CCAGCTCTGG CTACGATTCG GCTACACCGT CTGCCCTCGT GTCGCCCTCG 
TCGGACTGCG GCCACAAGTC CCAGGTGGCC TCCTCGGCGG CGGTGGCGGC GCGTACCGCC 
GACTTGAGCG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161850.1
CDS	187..1341
Translation	MPPFCRNAKLGLLSFLICAGRSLLPLGKNAFWLERIENNNTLWEKAQSQKMRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLNGLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMRQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDSATPSALVSPSSDCGHKSQVASSAAVAARTADLSE

Target ORF information:

RefSeq Version	NM_001168378.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Zic family member 4 (ZIC4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001168378.1

ORF Insert Sequence:

ATGCCGCCCT TCTGTAGGAA TGCAAAGTTA GGCCTCCTTT CTTTCCTGAT TTGTGCTGGA 
AGGAGCTTAT TACCTTTGGG GAAGAATGCC TTTTGGTTAG AAAGAATTGA AAATAATAAT 
ACCCTCTGGG AAAAGGCTCA AAGTCAGAAA ATGAGATACA AGACATCCTT GGTGATGAGG 
AAACGATTAC GGCTTTACCG AAACACTCTT AAAGAGTCAA GTAGCAGCTC TGGACACCAT 
GGCCCCCAGC TCACCGCCGC CTCCAGCCCC TCGGTGTTCC CGGGCCTCCA CGAGGAGCCT 
CCCCAGGCCT CCCCCAGCCG TCCTTTGAAT GGACTCCTGC GTCTGGGGCT CCCTGGAGAC 
ATGTACGCGC GGCCGGAGCC CTTCCCGCCA GGGCCTGCGG CCCGCAGCGA CGCCCTGGCA 
GCTGCCGCAG CCCTGCATGG CTACGGGGGC ATGAACCTGA CGGTGAACCT CGCTGCGCCC 
CACGGTCCTG GCGCTTTCTT CCGCTACATG CGCCAGCCCA TCAAACAGGA GCTCATCTGC 
AAGTGGCTGG CGGCCGACGG CACCGCGACC CCGAGCCTCT GCTCCAAAAC TTTCAGCACC 
ATGCACGAGC TGGTCACGCA CGTCACCGTG GAGCACGTCG GCGGCCCGGA ACAGGCCAAC 
CACATTTGCT TCTGGGAGGA GTGTCCGCGC CAGGGAAAGC CCTTCAAAGC CAAATACAAA 
CTTGTAAATC ACATCCGCGT GCACACGGGC GAGAAGCCCT TCCCTTGTCC TTTCCCGGGG 
TGTGGGAAGG TCTTTGCTAG ATCAGAAAAT CTCAAAATAC ACAAACGAAC TCACACAGGC 
GAGAAGCCCT TCAGATGCGA GTTCGAGGGC TGCGAGCGGC GCTTCGCCAA CAGCAGCGAC 
CGTAAGAAGC ATTCGCACGT GCACACTAGC GACAAGCCAT ACACGTGCAA GGTGCGGGGC 
TGCGACAAGT GCTACACGCA CCCCAGCTCG CTGCGTAAGC ACATGAAGGT GCACGGGCGC 
TCGCCGCCGC CCAGCTCTGG CTACGATTCG GCTACACCGT CTGCCCTCGT GTCGCCCTCG 
TCGGACTGCG GCCACAAGTC CCAGGTGGCC TCCTCGGCGG CGGTGGCGGC GCGTACCGCC 
GACTTGAGCG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZIC4 ( NM_001168379.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001161851.1 Homo sapiens Zic family member 4 (ZIC4), transcript variant 2, mRNA.

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CloneID	OHu32262
Clone ID Related Accession (Same CDS sequence)	NM_001168379.1
Accession Version	NM_001168379.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564761600000
Organism	Homo sapiens(human)
Product	zinc finger protein ZIC 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK293981.1, DA066220.1 and AK124600.1. Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter N-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK293981.1, SRR1803613.194072.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2147596 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATGGCC CATGTCAAAG TCTTAGGAAA GCGGAGGGGC TTTTGGAGGG TTGCACTTCG 
GCCGTCACCG TCTTCAGGAA ACTCCCTTTG GATTCCAAGG CTCAAAGTCA GAAAATGAGA 
TACAAGACAT CCTTGGTGAT GAGGAAACGA TTACGGCTTT ACCGAAACAC TCTTAAAGAG 
TCAAGTAGCA GCTCTGGACA CCATGGCCCC CAGCTCACCG CCGCCTCCAG CCCCTCGGTG 
TTCCCGGGCC TCCACGAGGA GCCTCCCCAG GCCTCCCCCA GCCGTCCTTT GAATGGACTC 
CTGCGTCTGG GGCTCCCTGG AGACATGTAC GCGCGGCCGG AGCCCTTCCC GCCAGGGCCT 
GCGGCCCGCA GCGACGCCCT GGCAGCTGCC GCAGCCCTGC ATGGCTACGG GGGCATGAAC 
CTGACGGTGA ACCTCGCTGC GCCCCACGGT CCTGGCGCTT TCTTCCGCTA CATGCGCCAG 
CCCATCAAAC AGGAGCTCAT CTGCAAGTGG CTGGCGGCCG ACGGCACCGC GACCCCGAGC 
CTCTGCTCCA AAACTTTCAG CACCATGCAC GAGCTGGTCA CGCACGTCAC CGTGGAGCAC 
GTCGGCGGCC CGGAACAGGC CAACCACATT TGCTTCTGGG AGGAGTGTCC GCGCCAGGGA 
AAGCCCTTCA AAGCCAAATA CAAACTTGTA AATCACATCC GCGTGCACAC GGGCGAGAAG 
CCCTTCCCTT GTCCTTTCCC GGGGTGTGGG AAGGTCTTTG CTAGATCAGA AAATCTCAAA 
ATACACAAAC GAACTCACAC AGGCGAGAAG CCCTTCAGAT GCGAGTTCGA GGGCTGCGAG 
CGGCGCTTCG CCAACAGCAG CGACCGTAAG AAGCATTCGC ACGTGCACAC TAGCGACAAG 
CCATACACGT GCAAGGTGCG GGGCTGCGAC AAGTGCTACA CGCACCCCAG CTCGCTGCGT 
AAGCACATGA AGGTGCACGG GCGCTCGCCG CCGCCCAGCT CTGGCTACGA TTCGGCTACA 
CCGTCTGCCC TCGTGTCGCC CTCGTCGGAC TGCGGCCACA AGTCCCAGGT GGCCTCCTCG 
GCGGCGGTGG CGGCGCGTAC CGCCGACTTG AGCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161851.1
CDS	50..1168
Translation	MNGPCQSLRKAEGLLEGCTSAVTVFRKLPLDSKAQSQKMRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLNGLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMRQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDSATPSALVSPSSDCGHKSQVASSAAVAARTADLSE

Target ORF information:

RefSeq Version	NM_001168379.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Zic family member 4 (ZIC4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001168379.1

ORF Insert Sequence:

ATGAATGGCC CATGTCAAAG TCTTAGGAAA GCGGAGGGGC TTTTGGAGGG TTGCACTTCG 
GCCGTCACCG TCTTCAGGAA ACTCCCTTTG GATTCCAAGG CTCAAAGTCA GAAAATGAGA 
TACAAGACAT CCTTGGTGAT GAGGAAACGA TTACGGCTTT ACCGAAACAC TCTTAAAGAG 
TCAAGTAGCA GCTCTGGACA CCATGGCCCC CAGCTCACCG CCGCCTCCAG CCCCTCGGTG 
TTCCCGGGCC TCCACGAGGA GCCTCCCCAG GCCTCCCCCA GCCGTCCTTT GAATGGACTC 
CTGCGTCTGG GGCTCCCTGG AGACATGTAC GCGCGGCCGG AGCCCTTCCC GCCAGGGCCT 
GCGGCCCGCA GCGACGCCCT GGCAGCTGCC GCAGCCCTGC ATGGCTACGG GGGCATGAAC 
CTGACGGTGA ACCTCGCTGC GCCCCACGGT CCTGGCGCTT TCTTCCGCTA CATGCGCCAG 
CCCATCAAAC AGGAGCTCAT CTGCAAGTGG CTGGCGGCCG ACGGCACCGC GACCCCGAGC 
CTCTGCTCCA AAACTTTCAG CACCATGCAC GAGCTGGTCA CGCACGTCAC CGTGGAGCAC 
GTCGGCGGCC CGGAACAGGC CAACCACATT TGCTTCTGGG AGGAGTGTCC GCGCCAGGGA 
AAGCCCTTCA AAGCCAAATA CAAACTTGTA AATCACATCC GCGTGCACAC GGGCGAGAAG 
CCCTTCCCTT GTCCTTTCCC GGGGTGTGGG AAGGTCTTTG CTAGATCAGA AAATCTCAAA 
ATACACAAAC GAACTCACAC AGGCGAGAAG CCCTTCAGAT GCGAGTTCGA GGGCTGCGAG 
CGGCGCTTCG CCAACAGCAG CGACCGTAAG AAGCATTCGC ACGTGCACAC TAGCGACAAG 
CCATACACGT GCAAGGTGCG GGGCTGCGAC AAGTGCTACA CGCACCCCAG CTCGCTGCGT 
AAGCACATGA AGGTGCACGG GCGCTCGCCG CCGCCCAGCT CTGGCTACGA TTCGGCTACA 
CCGTCTGCCC TCGTGTCGCC CTCGTCGGAC TGCGGCCACA AGTCCCAGGT GGCCTCCTCG 
GCGGCGGTGG CGGCGCGTAC CGCCGACTTG AGCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZIC4 ( XM_011513231.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511533.1 Homo sapiens Zic family member 4 (ZIC4), transcript variant X1, mRNA.

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CloneID	OHu19275
Clone ID Related Accession (Same CDS sequence)	XM_011513231.1 , NM_032153.5
Accession Version	XM_011513231.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426003200000
Organism	Homo sapiens(Human)
Product	zinc finger protein ZIC 4 isoform X1
Comment

ATGAGATACA AGACATCCTT GGTGATGAGG AAACGATTAC GGCTTTACCG AAACACTCTT 
AAAGAGTCAA GTAGCAGCTC TGGACACCAT GGCCCCCAGC TCACCGCCGC CTCCAGCCCC 
TCGGTGTTCC CGGGCCTCCA CGAGGAGCCT CCCCAGGCCT CCCCCAGCCG TCCTTTGAAT 
GGACTCCTGC GTCTGGGGCT CCCTGGAGAC ATGTACGCGC GGCCGGAGCC CTTCCCGCCA 
GGGCCTGCGG CCCGCAGCGA CGCCCTGGCA GCTGCCGCAG CCCTGCATGG CTACGGGGGC 
ATGAACCTGA CGGTGAACCT CGCTGCGCCC CACGGTCCTG GCGCTTTCTT CCGCTACATG 
CGCCAGCCCA TCAAACAGGA GCTCATCTGC AAGTGGCTGG CGGCCGACGG CACCGCGACC 
CCGAGCCTCT GCTCCAAAAC TTTCAGCACC ATGCACGAGC TGGTCACGCA CGTCACCGTG 
GAGCACGTCG GCGGCCCGGA ACAGGCCAAC CACATTTGCT TCTGGGAGGA GTGTCCGCGC 
CAGGGAAAGC CCTTCAAAGC CAAATACAAA CTTGTAAATC ACATCCGCGT GCACACGGGC 
GAGAAGCCCT TCCCTTGTCC TTTCCCGGGG TGTGGGAAGG TCTTTGCTAG ATCAGAAAAT 
CTCAAAATAC ACAAACGAAC TCACACAGGC GAGAAGCCCT TCAGATGCGA GTTCGAGGGC 
TGCGAGCGGC GCTTCGCCAA CAGCAGCGAC CGTAAGAAGC ATTCGCACGT GCACACTAGC 
GACAAGCCAT ACACGTGCAA GGTGCGGGGC TGCGACAAGT GCTACACGCA CCCCAGCTCG 
CTGCGTAAGC ACATGAAGGT GCACGGGCGC TCGCCGCCGC CCAGCTCTGG CTACGATTCG 
GCTACACCGT CTGCCCTCGT GTCGCCCTCG TCGGACTGCG GCCACAAGTC CCAGGTGGCC 
TCCTCGGCGG CGGTGGCGGC GCGTACCGCC GACTTGAGCG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511533.1
Translation	MRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLNGLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMRQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDSATPSALVSPSSDCGHKSQVASSAAVAARTADLSE

Target ORF information:

RefSeq Version	XM_011513231.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens Zic family member 4 (ZIC4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513231.1

ORF Insert Sequence:

ATGAGATACA AGACATCCTT GGTGATGAGG AAACGATTAC GGCTTTACCG AAACACTCTT 
AAAGAGTCAA GTAGCAGCTC TGGACACCAT GGCCCCCAGC TCACCGCCGC CTCCAGCCCC 
TCGGTGTTCC CGGGCCTCCA CGAGGAGCCT CCCCAGGCCT CCCCCAGCCG TCCTTTGAAT 
GGACTCCTGC GTCTGGGGCT CCCTGGAGAC ATGTACGCGC GGCCGGAGCC CTTCCCGCCA 
GGGCCTGCGG CCCGCAGCGA CGCCCTGGCA GCTGCCGCAG CCCTGCATGG CTACGGGGGC 
ATGAACCTGA CGGTGAACCT CGCTGCGCCC CACGGTCCTG GCGCTTTCTT CCGCTACATG 
CGCCAGCCCA TCAAACAGGA GCTCATCTGC AAGTGGCTGG CGGCCGACGG CACCGCGACC 
CCGAGCCTCT GCTCCAAAAC TTTCAGCACC ATGCACGAGC TGGTCACGCA CGTCACCGTG 
GAGCACGTCG GCGGCCCGGA ACAGGCCAAC CACATTTGCT TCTGGGAGGA GTGTCCGCGC 
CAGGGAAAGC CCTTCAAAGC CAAATACAAA CTTGTAAATC ACATCCGCGT GCACACGGGC 
GAGAAGCCCT TCCCTTGTCC TTTCCCGGGG TGTGGGAAGG TCTTTGCTAG ATCAGAAAAT 
CTCAAAATAC ACAAACGAAC TCACACAGGC GAGAAGCCCT TCAGATGCGA GTTCGAGGGC 
TGCGAGCGGC GCTTCGCCAA CAGCAGCGAC CGTAAGAAGC ATTCGCACGT GCACACTAGC 
GACAAGCCAT ACACGTGCAA GGTGCGGGGC TGCGACAAGT GCTACACGCA CCCCAGCTCG 
CTGCGTAAGC ACATGAAGGT GCACGGGCGC TCGCCGCCGC CCAGCTCTGG CTACGATTCG 
GCTACACCGT CTGCCCTCGT GTCGCCCTCG TCGGACTGCG GCCACAAGTC CCAGGTGGCC 
TCCTCGGCGG CGGTGGCGGC GCGTACCGCC GACTTGAGCG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas.
Clinical oral investigations21(5)1777-1788(2017 Jun)
Paluszczak J,Wiśniewska D,Kostrzewska-Poczekaj M,Kiwerska K,Grénman R,Mielcarek-Kuchta D,Jarmuż-Szymczak M

Genome-wide analysis of CpG island methylation in bladder cancer identified TBX2, TBX3, GATA2, and ZIC4 as pTa-specific prognostic markers.
European urology61(6)1245-56(2012 Jun)
Kandimalla R,van Tilborg AA,Kompier LC,Stumpel DJ,Stam RW,Bangma CH,Zwarthoff EC

Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion: Report of a new patient.
American journal of medical genetics. Part A155A(1)130-3(2011 Jan)
Tohyama J,Kato M,Kawasaki S,Harada N,Kawara H,Matsui T,Akasaka N,Ohashi T,Kobayashi Y,Matsumoto N

The ZIC gene family in development and disease.
Clinical genetics67(4)290-6(2005 Apr)
Grinberg I,Millen KJ

Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer.
Neurology63(7)1339; author reply 1339(2004 Oct)
Jaster JH

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ZIC4 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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