CASP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CASP4
Entrez Gene ID	837
Full Name	caspase 4
Synonyms	ICE(rel)II,ICEREL-II,ICH-2,Mih1,Mih1/TX,TX
General protein information	Preferred Names caspase 4 Names caspase-4 CASP-4 ICE and Ced-3 homolog 2 ICE(rel)-II apoptotic cysteine protease Mih1/TX caspase 4, apoptosis-related cysteine peptidase caspase 4, apoptosis-related cysteine protease protease ICH-2 protease TX
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q22.3
Summary	This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Disorder MIM:	602664

mRNA and Protein(s)

mRNA	Protein	Name
NM_001225.3	NP_001216.1	caspase-4 isoform alpha precursor
NM_033306.3	NP_150649.1	caspase-4 isoform gamma precursor
XM_017018397.1	XP_016873886.1	caspase-4 isoform X1
NM_033306.2	NP_150649.1	caspase-4 isoform gamma precursor
XM_011543019.1	XP_011541321.1	caspase-4 isoform X1
NM_001225.4	NP_001216.1	caspase-4 isoform alpha precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Casp4	NP_031635.2
Rattus norvegicus (Norway rat)	Casp4	NP_446188.2
Homo sapiens (human)	CASP4	NP_001216.1
Pan troglodytes (chimpanzee)	CASP4	XP_508729.2
Macaca mulatta (Rhesus monkey)	CASP4	XP_001100287.1
Bos taurus (cattle)	CASP4	NP_788811.1

Gene Ontology
Bibliography

Related articles in PubMed

SERPINB1-mediated checkpoint of inflammatory caspase activation.
Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU
Nature immunology20(3)276-287(2019 03)

Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D.
Quach J, Moreau F, Sandall C, Chadee K
Mucosal immunology12(2)323-339(2019 03)

CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion.
Papoff G, Presutti D, Lalli C, Bolasco G, Santini S, Manelfi C, Fustaino V, Alemà S, Ruberti G
Scientific reports8(1)17705(2018 12)

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome.
Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, Muruve DA
Cell reports25(6)1525-1536.e7(2018 11)

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury.
Zhang Z, Shao X, Jiang N, Mou S, Gu L, Li S, Lin Q, He Y, Zhang M, Zhou W, Ni Z
Cell death & disease9(10)983(2018 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CASP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CASP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu56652	XM_017018397.1 Latest version!	Homo sapiens caspase 4 (CASP4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu56652	XM_011543019.1 Latest version!	Homo sapiens caspase 4 (CASP4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu17307	NM_033306.3 Latest version!	Homo sapiens caspase 4 (CASP4), transcript variant gamma, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
OHu17372	NM_001225.4 Latest version!	Homo sapiens caspase 4 (CASP4), transcript variant alpha, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu17307	NM_033306.2	Homo sapiens caspase 4 (CASP4), transcript variant gamma, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
OHu17372	NM_001225.3	Homo sapiens caspase 4 (CASP4), transcript variant alpha, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CASP4 ( XM_017018397.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016873886.1 Homo sapiens caspase 4 (CASP4), transcript variant X1, mRNA.

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CloneID	OHu56652
Clone ID Related Accession (Same CDS sequence)	XM_017018397.1 , XM_011543019.1
Accession Version	XM_017018397.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	caspase-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGCTG GACCACCTGA GTCAGGAGAA TCTACAGATG CCCTCAAGCT TTGTCCTCAT 
GAAGAATTCC TGAGACTATG TAAAGAAAGA GCTGAAGAGA TCTATCCAAT AAAGGAGAGA 
AACAACCGCA CACGCCTGGC TCTCATCATA TGCAATACAG AGTTTGACCA TCTGCCTCCG 
AGGAATGGAG CTGACTTTGA CATCACAGGG ATGAAGGAGC TACTTGAGGG TCTGGACTAT 
AGTGTAGATG TAGAAGAGAA TCTGACAGCC AGGGATATGG AGTCAGCGCT GAGGGCATTT 
GCTACCAGAC CAGAGCACAA GTCCTCTGAC AGCACATTCT TGGTACTCAT GTCTCATGGC 
ATCCTGGAGG GAATCTGCGG AACTGTGCAT GATGAGAAAA AACCAGATGT GCTGCTTTAT 
GACACCATCT TCCAGATATT CAACAACCGC AACTGCCTCA GTCTGAAGGA CAAACCCAAG 
GTCATCATTG TCCAGGCCTG CAGAGGTGCA AACCGTGGGG AACTGTGGGT CAGAGACTCT 
CCAGCATCCT TGGAAGTGGC CTCTTCACAG TCATCTGAGA ACCTAGAGGA AGATGCTGTT 
TACAAGACCC ACGTGGAGAA GGACTTCATT GCTTTCTGCT CTTCAACGCC ACACAACGTG 
TCCTGGAGAG ACAGCACAAT GGGCTCTATC TTCATCACAC AACTCATCAC ATGCTTCCAG 
AAATATTCTT GGTGCTGCCA CCTAGAGGAA GTATTTCGGA AGGTACAGCA ATCATTTGAA 
ACTCCAAGGG CCAAAGCTCA AATGCCCACC ATAGAACGAC TGTCCATGAC AAGATATTTC 
TACCTCTTTC CTGGCAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016873886.1
CDS	347..1207
Translation	MEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN

Target ORF information:

RefSeq Version	XM_017018397.1
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase 4 (CASP4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017018397.1

ORF Insert Sequence:

ATGGAGGCTG GACCACCTGA GTCAGGAGAA TCTACAGATG CCCTCAAGCT TTGTCCTCAT 
GAAGAATTCC TGAGACTATG TAAAGAAAGA GCTGAAGAGA TCTATCCAAT AAAGGAGAGA 
AACAACCGCA CACGCCTGGC TCTCATCATA TGCAATACAG AGTTTGACCA TCTGCCTCCG 
AGGAATGGAG CTGACTTTGA CATCACAGGG ATGAAGGAGC TACTTGAGGG TCTGGACTAT 
AGTGTAGATG TAGAAGAGAA TCTGACAGCC AGGGATATGG AGTCAGCGCT GAGGGCATTT 
GCTACCAGAC CAGAGCACAA GTCCTCTGAC AGCACATTCT TGGTACTCAT GTCTCATGGC 
ATCCTGGAGG GAATCTGCGG AACTGTGCAT GATGAGAAAA AACCAGATGT GCTGCTTTAT 
GACACCATCT TCCAGATATT CAACAACCGC AACTGCCTCA GTCTGAAGGA CAAACCCAAG 
GTCATCATTG TCCAGGCCTG CAGAGGTGCA AACCGTGGGG AACTGTGGGT CAGAGACTCT 
CCAGCATCCT TGGAAGTGGC CTCTTCACAG TCATCTGAGA ACCTAGAGGA AGATGCTGTT 
TACAAGACCC ACGTGGAGAA GGACTTCATT GCTTTCTGCT CTTCAACGCC ACACAACGTG 
TCCTGGAGAG ACAGCACAAT GGGCTCTATC TTCATCACAC AACTCATCAC ATGCTTCCAG 
AAATATTCTT GGTGCTGCCA CCTAGAGGAA GTATTTCGGA AGGTACAGCA ATCATTTGAA 
ACTCCAAGGG CCAAAGCTCA AATGCCCACC ATAGAACGAC TGTCCATGAC AAGATATTTC 
TACCTCTTTC CTGGCAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASP4 ( XM_011543019.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011541321.1 Homo sapiens caspase 4 (CASP4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu56652
Clone ID Related Accession (Same CDS sequence)	XM_017018397.1 , XM_011543019.1
Accession Version	XM_011543019.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	caspase-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGCTG GACCACCTGA GTCAGGAGAA TCTACAGATG CCCTCAAGCT TTGTCCTCAT 
GAAGAATTCC TGAGACTATG TAAAGAAAGA GCTGAAGAGA TCTATCCAAT AAAGGAGAGA 
AACAACCGCA CACGCCTGGC TCTCATCATA TGCAATACAG AGTTTGACCA TCTGCCTCCG 
AGGAATGGAG CTGACTTTGA CATCACAGGG ATGAAGGAGC TACTTGAGGG TCTGGACTAT 
AGTGTAGATG TAGAAGAGAA TCTGACAGCC AGGGATATGG AGTCAGCGCT GAGGGCATTT 
GCTACCAGAC CAGAGCACAA GTCCTCTGAC AGCACATTCT TGGTACTCAT GTCTCATGGC 
ATCCTGGAGG GAATCTGCGG AACTGTGCAT GATGAGAAAA AACCAGATGT GCTGCTTTAT 
GACACCATCT TCCAGATATT CAACAACCGC AACTGCCTCA GTCTGAAGGA CAAACCCAAG 
GTCATCATTG TCCAGGCCTG CAGAGGTGCA AACCGTGGGG AACTGTGGGT CAGAGACTCT 
CCAGCATCCT TGGAAGTGGC CTCTTCACAG TCATCTGAGA ACCTAGAGGA AGATGCTGTT 
TACAAGACCC ACGTGGAGAA GGACTTCATT GCTTTCTGCT CTTCAACGCC ACACAACGTG 
TCCTGGAGAG ACAGCACAAT GGGCTCTATC TTCATCACAC AACTCATCAC ATGCTTCCAG 
AAATATTCTT GGTGCTGCCA CCTAGAGGAA GTATTTCGGA AGGTACAGCA ATCATTTGAA 
ACTCCAAGGG CCAAAGCTCA AATGCCCACC ATAGAACGAC TGTCCATGAC AAGATATTTC 
TACCTCTTTC CTGGCAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011541321.1
CDS	403..1263
Translation	MEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN

Target ORF information:

RefSeq Version	XM_011543019.1
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase 4 (CASP4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011543019.1

ORF Insert Sequence:

ATGGAGGCTG GACCACCTGA GTCAGGAGAA TCTACAGATG CCCTCAAGCT TTGTCCTCAT 
GAAGAATTCC TGAGACTATG TAAAGAAAGA GCTGAAGAGA TCTATCCAAT AAAGGAGAGA 
AACAACCGCA CACGCCTGGC TCTCATCATA TGCAATACAG AGTTTGACCA TCTGCCTCCG 
AGGAATGGAG CTGACTTTGA CATCACAGGG ATGAAGGAGC TACTTGAGGG TCTGGACTAT 
AGTGTAGATG TAGAAGAGAA TCTGACAGCC AGGGATATGG AGTCAGCGCT GAGGGCATTT 
GCTACCAGAC CAGAGCACAA GTCCTCTGAC AGCACATTCT TGGTACTCAT GTCTCATGGC 
ATCCTGGAGG GAATCTGCGG AACTGTGCAT GATGAGAAAA AACCAGATGT GCTGCTTTAT 
GACACCATCT TCCAGATATT CAACAACCGC AACTGCCTCA GTCTGAAGGA CAAACCCAAG 
GTCATCATTG TCCAGGCCTG CAGAGGTGCA AACCGTGGGG AACTGTGGGT CAGAGACTCT 
CCAGCATCCT TGGAAGTGGC CTCTTCACAG TCATCTGAGA ACCTAGAGGA AGATGCTGTT 
TACAAGACCC ACGTGGAGAA GGACTTCATT GCTTTCTGCT CTTCAACGCC ACACAACGTG 
TCCTGGAGAG ACAGCACAAT GGGCTCTATC TTCATCACAC AACTCATCAC ATGCTTCCAG 
AAATATTCTT GGTGCTGCCA CCTAGAGGAA GTATTTCGGA AGGTACAGCA ATCATTTGAA 
ACTCCAAGGG CCAAAGCTCA AATGCCCACC ATAGAACGAC TGTCCATGAC AAGATATTTC 
TACCTCTTTC CTGGCAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASP4 ( NM_033306.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_150649.1 Homo sapiens caspase 4 (CASP4), transcript variant gamma, mRNA.

Price & Availability↑

CloneID	OHu17307
Clone ID Related Accession (Same CDS sequence)	NM_033306.3 , NM_033306.2
Accession Version	NM_033306.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1578067200000
Organism	Homo sapiens(human)
Product	caspase-4 isoform gamma precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001153.5, U28978.1, AI128358.1 and AP002004.4. On May 31, 2019 this sequence version replaced NM_033306.2. Transcript Variant: This variant (gamma) includes an alternate exon in the 5' UTR and 5' coding region and uses a downstream in-frame start codon, compared to variant alpha. It encodes isoform gamma, which is shorter than isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U28978.1, U28977.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGACT CTATGCAAGA GAAGCAACGT ATGGCAGGAC AAATGCTTCT TCAAACCTTT 
TTTAACATAG ACCAAATATC CCCCAATAAA AAAGCTCATC CGAATATGGA GGCTGGACCA 
CCTGAGTCAG GAGAATCTAC AGATGCCCTC AAGCTTTGTC CTCATGAAGA ATTCCTGAGA 
CTATGTAAAG AAAGAGCTGA AGAGATCTAT CCAATAAAGG AGAGAAACAA CCGCACACGC 
CTGGCTCTCA TCATATGCAA TACAGAGTTT GACCATCTGC CTCCGAGGAA TGGAGCTGAC 
TTTGACATCA CAGGGATGAA GGAGCTACTT GAGGGTCTGG ACTATAGTGT AGATGTAGAA 
GAGAATCTGA CAGCCAGGGA TATGGAGTCA GCGCTGAGGG CATTTGCTAC CAGACCAGAG 
CACAAGTCCT CTGACAGCAC ATTCTTGGTA CTCATGTCTC ATGGCATCCT GGAGGGAATC 
TGCGGAACTG TGCATGATGA GAAAAAACCA GATGTGCTGC TTTATGACAC CATCTTCCAG 
ATATTCAACA ACCGCAACTG CCTCAGTCTG AAGGACAAAC CCAAGGTCAT CATTGTCCAG 
GCCTGCAGAG GTGCAAACCG TGGGGAACTG TGGGTCAGAG ACTCTCCAGC ATCCTTGGAA 
GTGGCCTCTT CACAGTCATC TGAGAACCTA GAGGAAGATG CTGTTTACAA GACCCACGTG 
GAGAAGGACT TCATTGCTTT CTGCTCTTCA ACGCCACACA ACGTGTCCTG GAGAGACAGC 
ACAATGGGCT CTATCTTCAT CACACAACTC ATCACATGCT TCCAGAAATA TTCTTGGTGC 
TGCCACCTAG AGGAAGTATT TCGGAAGGTA CAGCAATCAT TTGAAACTCC AAGGGCCAAA 
GCTCAAATGC CCACCATAGA ACGACTGTCC ATGACAAGAT ATTTCTACCT CTTTCCTGGC 
AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150649.1
CDS	317..1282
Translation	MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN

Target ORF information:

RefSeq Version	NM_033306.3
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase 4 (CASP4), transcript variant gamma, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033306.3

ORF Insert Sequence:

ATGGCAGACT CTATGCAAGA GAAGCAACGT ATGGCAGGAC AAATGCTTCT TCAAACCTTT 
TTTAACATAG ACCAAATATC CCCCAATAAA AAAGCTCATC CGAATATGGA GGCTGGACCA 
CCTGAGTCAG GAGAATCTAC AGATGCCCTC AAGCTTTGTC CTCATGAAGA ATTCCTGAGA 
CTATGTAAAG AAAGAGCTGA AGAGATCTAT CCAATAAAGG AGAGAAACAA CCGCACACGC 
CTGGCTCTCA TCATATGCAA TACAGAGTTT GACCATCTGC CTCCGAGGAA TGGAGCTGAC 
TTTGACATCA CAGGGATGAA GGAGCTACTT GAGGGTCTGG ACTATAGTGT AGATGTAGAA 
GAGAATCTGA CAGCCAGGGA TATGGAGTCA GCGCTGAGGG CATTTGCTAC CAGACCAGAG 
CACAAGTCCT CTGACAGCAC ATTCTTGGTA CTCATGTCTC ATGGCATCCT GGAGGGAATC 
TGCGGAACTG TGCATGATGA GAAAAAACCA GATGTGCTGC TTTATGACAC CATCTTCCAG 
ATATTCAACA ACCGCAACTG CCTCAGTCTG AAGGACAAAC CCAAGGTCAT CATTGTCCAG 
GCCTGCAGAG GTGCAAACCG TGGGGAACTG TGGGTCAGAG ACTCTCCAGC ATCCTTGGAA 
GTGGCCTCTT CACAGTCATC TGAGAACCTA GAGGAAGATG CTGTTTACAA GACCCACGTG 
GAGAAGGACT TCATTGCTTT CTGCTCTTCA ACGCCACACA ACGTGTCCTG GAGAGACAGC 
ACAATGGGCT CTATCTTCAT CACACAACTC ATCACATGCT TCCAGAAATA TTCTTGGTGC 
TGCCACCTAG AGGAAGTATT TCGGAAGGTA CAGCAATCAT TTGAAACTCC AAGGGCCAAA 
GCTCAAATGC CCACCATAGA ACGACTGTCC ATGACAAGAT ATTTCTACCT CTTTCCTGGC 
AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASP4 ( NM_033306.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_150649.1 Homo sapiens caspase 4 (CASP4), transcript variant gamma, mRNA.

Price & Availability↑

CloneID	OHu17307
Clone ID Related Accession (Same CDS sequence)	NM_033306.3 , NM_033306.2
Accession Version	NM_033306.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1551542400000
Organism	Homo sapiens(human)
Product	caspase-4 isoform gamma precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U28978.1 and AI128358.1. On Aug 19, 2005 this sequence version replaced NM_033306.1. Transcript Variant: This variant (gamma) includes an alternate exon in the 5' UTR and 5' coding region and uses a downstream in-frame start codon, compared to variant alpha. It encodes isoform gamma, which is shorter than isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U28977.1, U28978.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGACT CTATGCAAGA GAAGCAACGT ATGGCAGGAC AAATGCTTCT TCAAACCTTT 
TTTAACATAG ACCAAATATC CCCCAATAAA AAAGCTCATC CGAATATGGA GGCTGGACCA 
CCTGAGTCAG GAGAATCTAC AGATGCCCTC AAGCTTTGTC CTCATGAAGA ATTCCTGAGA 
CTATGTAAAG AAAGAGCTGA AGAGATCTAT CCAATAAAGG AGAGAAACAA CCGCACACGC 
CTGGCTCTCA TCATATGCAA TACAGAGTTT GACCATCTGC CTCCGAGGAA TGGAGCTGAC 
TTTGACATCA CAGGGATGAA GGAGCTACTT GAGGGTCTGG ACTATAGTGT AGATGTAGAA 
GAGAATCTGA CAGCCAGGGA TATGGAGTCA GCGCTGAGGG CATTTGCTAC CAGACCAGAG 
CACAAGTCCT CTGACAGCAC ATTCTTGGTA CTCATGTCTC ATGGCATCCT GGAGGGAATC 
TGCGGAACTG TGCATGATGA GAAAAAACCA GATGTGCTGC TTTATGACAC CATCTTCCAG 
ATATTCAACA ACCGCAACTG CCTCAGTCTG AAGGACAAAC CCAAGGTCAT CATTGTCCAG 
GCCTGCAGAG GTGCAAACCG TGGGGAACTG TGGGTCAGAG ACTCTCCAGC ATCCTTGGAA 
GTGGCCTCTT CACAGTCATC TGAGAACCTA GAGGAAGATG CTGTTTACAA GACCCACGTG 
GAGAAGGACT TCATTGCTTT CTGCTCTTCA ACGCCACACA ACGTGTCCTG GAGAGACAGC 
ACAATGGGCT CTATCTTCAT CACACAACTC ATCACATGCT TCCAGAAATA TTCTTGGTGC 
TGCCACCTAG AGGAAGTATT TCGGAAGGTA CAGCAATCAT TTGAAACTCC AAGGGCCAAA 
GCTCAAATGC CCACCATAGA ACGACTGTCC ATGACAAGAT ATTTCTACCT CTTTCCTGGC 
AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150649.1
CDS	275..1240
Translation	MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN

Target ORF information:

RefSeq Version	NM_033306.2
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase 4 (CASP4), transcript variant gamma, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033306.2

ORF Insert Sequence:

ATGGCAGACT CTATGCAAGA GAAGCAACGT ATGGCAGGAC AAATGCTTCT TCAAACCTTT 
TTTAACATAG ACCAAATATC CCCCAATAAA AAAGCTCATC CGAATATGGA GGCTGGACCA 
CCTGAGTCAG GAGAATCTAC AGATGCCCTC AAGCTTTGTC CTCATGAAGA ATTCCTGAGA 
CTATGTAAAG AAAGAGCTGA AGAGATCTAT CCAATAAAGG AGAGAAACAA CCGCACACGC 
CTGGCTCTCA TCATATGCAA TACAGAGTTT GACCATCTGC CTCCGAGGAA TGGAGCTGAC 
TTTGACATCA CAGGGATGAA GGAGCTACTT GAGGGTCTGG ACTATAGTGT AGATGTAGAA 
GAGAATCTGA CAGCCAGGGA TATGGAGTCA GCGCTGAGGG CATTTGCTAC CAGACCAGAG 
CACAAGTCCT CTGACAGCAC ATTCTTGGTA CTCATGTCTC ATGGCATCCT GGAGGGAATC 
TGCGGAACTG TGCATGATGA GAAAAAACCA GATGTGCTGC TTTATGACAC CATCTTCCAG 
ATATTCAACA ACCGCAACTG CCTCAGTCTG AAGGACAAAC CCAAGGTCAT CATTGTCCAG 
GCCTGCAGAG GTGCAAACCG TGGGGAACTG TGGGTCAGAG ACTCTCCAGC ATCCTTGGAA 
GTGGCCTCTT CACAGTCATC TGAGAACCTA GAGGAAGATG CTGTTTACAA GACCCACGTG 
GAGAAGGACT TCATTGCTTT CTGCTCTTCA ACGCCACACA ACGTGTCCTG GAGAGACAGC 
ACAATGGGCT CTATCTTCAT CACACAACTC ATCACATGCT TCCAGAAATA TTCTTGGTGC 
TGCCACCTAG AGGAAGTATT TCGGAAGGTA CAGCAATCAT TTGAAACTCC AAGGGCCAAA 
GCTCAAATGC CCACCATAGA ACGACTGTCC ATGACAAGAT ATTTCTACCT CTTTCCTGGC 
AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASP4 ( NM_001225.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001216.1 Homo sapiens caspase 4 (CASP4), transcript variant alpha, mRNA.

Price & Availability↑

CloneID	OHu17372
Clone ID Related Accession (Same CDS sequence)	NM_001225.3 , NM_001225.4
Accession Version	NM_001225.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1509120000000
Organism	Homo sapiens(human)
Product	caspase-4 isoform alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN261701.1, Z48810.1 and AI128358.1. On Aug 19, 2005 this sequence version replaced NM_001225.2. Transcript Variant: This variant (alpha) encodes the longest isoform (alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK057094.1, SRR1163657.44485.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAAG GCAACCACAG AAAAAAGCCA CTTAAGGTGT TGGAATCCCT GGGCAAAGAT 
TTCCTCACTG GTGTTTTGGA TAACTTGGTG GAACAAAATG TACTGAACTG GAAGGAAGAG 
GAAAAAAAGA AATATTACGA TGCTAAAACT GAAGACAAAG TTCGGGTCAT GGCAGACTCT 
ATGCAAGAGA AGCAACGTAT GGCAGGACAA ATGCTTCTTC AAACCTTTTT TAACATAGAC 
CAAATATCCC CCAATAAAAA AGCTCATCCG AATATGGAGG CTGGACCACC TGAGTCAGGA 
GAATCTACAG ATGCCCTCAA GCTTTGTCCT CATGAAGAAT TCCTGAGACT ATGTAAAGAA 
AGAGCTGAAG AGATCTATCC AATAAAGGAG AGAAACAACC GCACACGCCT GGCTCTCATC 
ATATGCAATA CAGAGTTTGA CCATCTGCCT CCGAGGAATG GAGCTGACTT TGACATCACA 
GGGATGAAGG AGCTACTTGA GGGTCTGGAC TATAGTGTAG ATGTAGAAGA GAATCTGACA 
GCCAGGGATA TGGAGTCAGC GCTGAGGGCA TTTGCTACCA GACCAGAGCA CAAGTCCTCT 
GACAGCACAT TCTTGGTACT CATGTCTCAT GGCATCCTGG AGGGAATCTG CGGAACTGTG 
CATGATGAGA AAAAACCAGA TGTGCTGCTT TATGACACCA TCTTCCAGAT ATTCAACAAC 
CGCAACTGCC TCAGTCTGAA GGACAAACCC AAGGTCATCA TTGTCCAGGC CTGCAGAGGT 
GCAAACCGTG GGGAACTGTG GGTCAGAGAC TCTCCAGCAT CCTTGGAAGT GGCCTCTTCA 
CAGTCATCTG AGAACCTAGA GGAAGATGCT GTTTACAAGA CCCACGTGGA GAAGGACTTC 
ATTGCTTTCT GCTCTTCAAC GCCACACAAC GTGTCCTGGA GAGACAGCAC AATGGGCTCT 
ATCTTCATCA CACAACTCAT CACATGCTTC CAGAAATATT CTTGGTGCTG CCACCTAGAG 
GAAGTATTTC GGAAGGTACA GCAATCATTT GAAACTCCAA GGGCCAAAGC TCAAATGCCC 
ACCATAGAAC GACTGTCCAT GACAAGATAT TTCTACCTCT TTCCTGGCAA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001216.1
CDS	74..1207
Translation	MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN

Target ORF information:

RefSeq Version	NM_001225.3
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase 4 (CASP4), transcript variant alpha, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001225.3

ORF Insert Sequence:

ATGGCAGAAG GCAACCACAG AAAAAAGCCA CTTAAGGTGT TGGAATCCCT GGGCAAAGAT 
TTCCTCACTG GTGTTTTGGA TAACTTGGTG GAACAAAATG TACTGAACTG GAAGGAAGAG 
GAAAAAAAGA AATATTACGA TGCTAAAACT GAAGACAAAG TTCGGGTCAT GGCAGACTCT 
ATGCAAGAGA AGCAACGTAT GGCAGGACAA ATGCTTCTTC AAACCTTTTT TAACATAGAC 
CAAATATCCC CCAATAAAAA AGCTCATCCG AATATGGAGG CTGGACCACC TGAGTCAGGA 
GAATCTACAG ATGCCCTCAA GCTTTGTCCT CATGAAGAAT TCCTGAGACT ATGTAAAGAA 
AGAGCTGAAG AGATCTATCC AATAAAGGAG AGAAACAACC GCACACGCCT GGCTCTCATC 
ATATGCAATA CAGAGTTTGA CCATCTGCCT CCGAGGAATG GAGCTGACTT TGACATCACA 
GGGATGAAGG AGCTACTTGA GGGTCTGGAC TATAGTGTAG ATGTAGAAGA GAATCTGACA 
GCCAGGGATA TGGAGTCAGC GCTGAGGGCA TTTGCTACCA GACCAGAGCA CAAGTCCTCT 
GACAGCACAT TCTTGGTACT CATGTCTCAT GGCATCCTGG AGGGAATCTG CGGAACTGTG 
CATGATGAGA AAAAACCAGA TGTGCTGCTT TATGACACCA TCTTCCAGAT ATTCAACAAC 
CGCAACTGCC TCAGTCTGAA GGACAAACCC AAGGTCATCA TTGTCCAGGC CTGCAGAGGT 
GCAAACCGTG GGGAACTGTG GGTCAGAGAC TCTCCAGCAT CCTTGGAAGT GGCCTCTTCA 
CAGTCATCTG AGAACCTAGA GGAAGATGCT GTTTACAAGA CCCACGTGGA GAAGGACTTC 
ATTGCTTTCT GCTCTTCAAC GCCACACAAC GTGTCCTGGA GAGACAGCAC AATGGGCTCT 
ATCTTCATCA CACAACTCAT CACATGCTTC CAGAAATATT CTTGGTGCTG CCACCTAGAG 
GAAGTATTTC GGAAGGTACA GCAATCATTT GAAACTCCAA GGGCCAAAGC TCAAATGCCC 
ACCATAGAAC GACTGTCCAT GACAAGATAT TTCTACCTCT TTCCTGGCAA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASP4 ( NM_001225.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001216.1 Homo sapiens caspase 4 (CASP4), transcript variant alpha, mRNA.

Price & Availability↑

CloneID	OHu17372
Clone ID Related Accession (Same CDS sequence)	NM_001225.3 , NM_001225.4
Accession Version	NM_001225.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1578067200000
Organism	Homo sapiens(human)
Product	caspase-4 isoform alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN261701.1, Z48810.1, AI128358.1 and AP002004.4. On Nov 22, 2018 this sequence version replaced NM_001225.3. Transcript Variant: This variant (alpha) encodes the longest isoform (alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.69442.1, SRR1163657.532215.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000444739.7/ ENSP00000388566.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGAAG GCAACCACAG AAAAAAGCCA CTTAAGGTGT TGGAATCCCT GGGCAAAGAT 
TTCCTCACTG GTGTTTTGGA TAACTTGGTG GAACAAAATG TACTGAACTG GAAGGAAGAG 
GAAAAAAAGA AATATTACGA TGCTAAAACT GAAGACAAAG TTCGGGTCAT GGCAGACTCT 
ATGCAAGAGA AGCAACGTAT GGCAGGACAA ATGCTTCTTC AAACCTTTTT TAACATAGAC 
CAAATATCCC CCAATAAAAA AGCTCATCCG AATATGGAGG CTGGACCACC TGAGTCAGGA 
GAATCTACAG ATGCCCTCAA GCTTTGTCCT CATGAAGAAT TCCTGAGACT ATGTAAAGAA 
AGAGCTGAAG AGATCTATCC AATAAAGGAG AGAAACAACC GCACACGCCT GGCTCTCATC 
ATATGCAATA CAGAGTTTGA CCATCTGCCT CCGAGGAATG GAGCTGACTT TGACATCACA 
GGGATGAAGG AGCTACTTGA GGGTCTGGAC TATAGTGTAG ATGTAGAAGA GAATCTGACA 
GCCAGGGATA TGGAGTCAGC GCTGAGGGCA TTTGCTACCA GACCAGAGCA CAAGTCCTCT 
GACAGCACAT TCTTGGTACT CATGTCTCAT GGCATCCTGG AGGGAATCTG CGGAACTGTG 
CATGATGAGA AAAAACCAGA TGTGCTGCTT TATGACACCA TCTTCCAGAT ATTCAACAAC 
CGCAACTGCC TCAGTCTGAA GGACAAACCC AAGGTCATCA TTGTCCAGGC CTGCAGAGGT 
GCAAACCGTG GGGAACTGTG GGTCAGAGAC TCTCCAGCAT CCTTGGAAGT GGCCTCTTCA 
CAGTCATCTG AGAACCTAGA GGAAGATGCT GTTTACAAGA CCCACGTGGA GAAGGACTTC 
ATTGCTTTCT GCTCTTCAAC GCCACACAAC GTGTCCTGGA GAGACAGCAC AATGGGCTCT 
ATCTTCATCA CACAACTCAT CACATGCTTC CAGAAATATT CTTGGTGCTG CCACCTAGAG 
GAAGTATTTC GGAAGGTACA GCAATCATTT GAAACTCCAA GGGCCAAAGC TCAAATGCCC 
ACCATAGAAC GACTGTCCAT GACAAGATAT TTCTACCTCT TTCCTGGCAA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001216.1
CDS	50..1183
Translation	MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN

Target ORF information:

RefSeq Version	NM_001225.4
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase 4 (CASP4), transcript variant alpha, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001225.4

ORF Insert Sequence:

ATGGCAGAAG GCAACCACAG AAAAAAGCCA CTTAAGGTGT TGGAATCCCT GGGCAAAGAT 
TTCCTCACTG GTGTTTTGGA TAACTTGGTG GAACAAAATG TACTGAACTG GAAGGAAGAG 
GAAAAAAAGA AATATTACGA TGCTAAAACT GAAGACAAAG TTCGGGTCAT GGCAGACTCT 
ATGCAAGAGA AGCAACGTAT GGCAGGACAA ATGCTTCTTC AAACCTTTTT TAACATAGAC 
CAAATATCCC CCAATAAAAA AGCTCATCCG AATATGGAGG CTGGACCACC TGAGTCAGGA 
GAATCTACAG ATGCCCTCAA GCTTTGTCCT CATGAAGAAT TCCTGAGACT ATGTAAAGAA 
AGAGCTGAAG AGATCTATCC AATAAAGGAG AGAAACAACC GCACACGCCT GGCTCTCATC 
ATATGCAATA CAGAGTTTGA CCATCTGCCT CCGAGGAATG GAGCTGACTT TGACATCACA 
GGGATGAAGG AGCTACTTGA GGGTCTGGAC TATAGTGTAG ATGTAGAAGA GAATCTGACA 
GCCAGGGATA TGGAGTCAGC GCTGAGGGCA TTTGCTACCA GACCAGAGCA CAAGTCCTCT 
GACAGCACAT TCTTGGTACT CATGTCTCAT GGCATCCTGG AGGGAATCTG CGGAACTGTG 
CATGATGAGA AAAAACCAGA TGTGCTGCTT TATGACACCA TCTTCCAGAT ATTCAACAAC 
CGCAACTGCC TCAGTCTGAA GGACAAACCC AAGGTCATCA TTGTCCAGGC CTGCAGAGGT 
GCAAACCGTG GGGAACTGTG GGTCAGAGAC TCTCCAGCAT CCTTGGAAGT GGCCTCTTCA 
CAGTCATCTG AGAACCTAGA GGAAGATGCT GTTTACAAGA CCCACGTGGA GAAGGACTTC 
ATTGCTTTCT GCTCTTCAAC GCCACACAAC GTGTCCTGGA GAGACAGCAC AATGGGCTCT 
ATCTTCATCA CACAACTCAT CACATGCTTC CAGAAATATT CTTGGTGCTG CCACCTAGAG 
GAAGTATTTC GGAAGGTACA GCAATCATTT GAAACTCCAA GGGCCAAAGC TCAAATGCCC 
ACCATAGAAC GACTGTCCAT GACAAGATAT TTCTACCTCT TTCCTGGCAA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SERPINB1-mediated checkpoint of inflammatory caspase activation.
Nature immunology20(3)276-287(2019 03)
Choi YJ,Kim S,Choi Y,Nielsen TB,Yan J,Lu A,Ruan J,Lee HR,Wu H,Spellberg B,Jung JU

Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D.
Mucosal immunology12(2)323-339(2019 03)
Quach J,Moreau F,Sandall C,Chadee K

CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion.
Scientific reports8(1)17705(2018 12)
Papoff G,Presutti D,Lalli C,Bolasco G,Santini S,Manelfi C,Fustaino V,Alemà S,Ruberti G

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome.
Cell reports25(6)1525-1536.e7(2018 11)
Platnich JM,Chung H,Lau A,Sandall CF,Bondzi-Simpson A,Chen HM,Komada T,Trotman-Grant AC,Brandelli JR,Chun J,Beck PL,Philpott DJ,Girardin SE,Ho M,Johnson RP,MacDonald JA,Armstrong GD,Muruve DA

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury.
Cell death & disease9(10)983(2018 09)
Zhang Z,Shao X,Jiang N,Mou S,Gu L,Li S,Lin Q,He Y,Zhang M,Zhou W,Ni Z

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CASP4 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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