APH1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	APH1B
Entrez Gene ID	83464
Full Name	aph-1 homolog B, gamma-secretase subunit
Synonyms	APH-1B,PRO1328,PSFL,TAAV688
General protein information	Preferred Names aph-1 homolog B, gamma-secretase subunit Names gamma-secretase subunit APH-1B APH1B gamma secretase subunit anterior pharynx defective 1 homolog B aph-1beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q22.2
Summary	This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011].
Disorder MIM:	607630

mRNA and Protein(s)

mRNA	Protein	Name
XM_011522105.3	XP_011520407.1	gamma-secretase subunit APH-1B isoform X1
NM_001145646.1	NP_001139118.1	gamma-secretase subunit APH-1B isoform 2
NM_031301.3	NP_112591.2	gamma-secretase subunit APH-1B isoform 1
NM_031301.4	NP_112591.2	gamma-secretase subunit APH-1B isoform 1
XM_024450086.1	XP_024305854.1	gamma-secretase subunit APH-1B isoform X2
XM_024450085.1	XP_024305853.1	gamma-secretase subunit APH-1B isoform X2
XM_011522105.2	XP_011520407.1	gamma-secretase subunit APH-1B isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	APH1B	XP_005638754.1
Pan troglodytes (chimpanzee)	APH1B	XP_523094.2
Macaca mulatta (Rhesus monkey)	APH1B	XP_001105067.1
Mus musculus (house mouse)	Aph1b	NP_808251.1
Homo sapiens (human)	APH1B	NP_112591.2

Gene Ontology
Bibliography

Related articles in PubMed

Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
Yonemura Y, Futai E, Yagishita S, Kaether C, Ishiura S
Biochemical and biophysical research communications478(4)1751-7(2016 09)

Imatinib methanesulfonate reduces hippocampal amyloid-β and restores cognitive function following repeated endotoxin exposure.
Weintraub MK, Bisson CM, Nouri JN, Vinson BT, Eimerbrink MJ, Kranjac D, Boehm GW, Chumley MJ
Brain, behavior, and immunity3324-8(2013 Oct)

Correlation between HIV-1 seropositivity and prevalence of a gamma-secretase polymorphism in two distinct ethnic populations.
van Loo KM, van Schijndel JE, van Zweeden M, van Manen D, Trip MD, Petersen DC, Schuitemaker H, Hayes VM, Martens GJ
Journal of medical virology81(11)1847-51(2009 Nov)

Male-specific association between a gamma-secretase polymorphism and premature coronary atherosclerosis.
van Loo KM, Dejaegere T, van Zweeden M, van Schijndel JE, Wijmenga C, Trip MD, Martens GJ
PloS one3(11)e3662(2008)

Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?
Bronfman FC
Journal of neurochemistry103 Suppl 191-100(2007 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following APH1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APH1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23882	NM_001145646.1 Latest version!	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu104065	XM_024450086.1 Latest version!	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu104065	XM_024450085.1 Latest version!	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu73063	XM_011522105.3 Latest version!	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu23746	NM_031301.4 Latest version!	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu23746	NM_031301.3	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu73063	XM_011522105.2	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APH1B ( NM_001145646.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139118.1 Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23882
Clone ID Related Accession (Same CDS sequence)	NM_001145646.1
Accession Version	NM_001145646.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573747200000
Organism	Homo sapiens(human)
Product	gamma-secretase subunit APH-1B isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA397427.1, AB189172.1, AC016207.9 and AI693802.1. Transcript Variant: This variant (2) lacks an in-frame coding exon and encodes a shorter isoform (2), as compared to variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.12016.1, BQ429210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGACTGCGG CCGTGTTCTT CGGCTGCGCC TTCATTGCCT TCGGGCCTGC GCTCGCCCTT 
TATGTCTTCA CCATCGCCAC CGAGCCGTTG CGTATCATCT TCCTCATCGC CGGAGCTTTC 
TTCTGGTTGG TGTCTCTACT GATTTCGTCC CTTGTTTGGT TCATGGCAAG AGTCATTATT 
GACAACAAAG ATGGACCAAC ACAGAAATAT CTGCTGATCT TTGGAGCGTT TGTCTCTGTC 
TATATCCAAG AAATGTTCCG ATTTGCATAT TATAAACTCT TAAAAAAAGC CAGTGAAGGT 
TTGAAGAGTA TAAACCCAGG TGAGACAGCA CCCTCTATGC GACTGCTGGC CTATGCTTTC 
ATGACGCTGG TCATTATCTT GCTGCATGTA TTCTGGGGCA TTGTATTTTT TGATGGCTGT 
GAGAAGAAAA AGTGGGGCAT CCTCCTTATC GTTCTCCTGA CCCACCTGCT GGTGTCAGCC 
CAGACCTTCA TAAGTTCTTA TTATGGAATA AACCTGGCGT CAGCATTTAT AATCCTGGTG 
CTCATGGGCA CCTGGGCATT CTTAGCTGCG GGAGGCAGCT GCCGAAGCCT GAAACTCTGC 
CTGCTCTGCC AAGACAAGAA CTTTCTTCTT TACAACCAGC GCTCCAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139118.1
CDS	75..725
Translation	MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKNFLLYNQRSR

Target ORF information:

RefSeq Version	NM_001145646.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145646.1

ORF Insert Sequence:

ATGACTGCGG CCGTGTTCTT CGGCTGCGCC TTCATTGCCT TCGGGCCTGC GCTCGCCCTT 
TATGTCTTCA CCATCGCCAC CGAGCCGTTG CGTATCATCT TCCTCATCGC CGGAGCTTTC 
TTCTGGTTGG TGTCTCTACT GATTTCGTCC CTTGTTTGGT TCATGGCAAG AGTCATTATT 
GACAACAAAG ATGGACCAAC ACAGAAATAT CTGCTGATCT TTGGAGCGTT TGTCTCTGTC 
TATATCCAAG AAATGTTCCG ATTTGCATAT TATAAACTCT TAAAAAAAGC CAGTGAAGGT 
TTGAAGAGTA TAAACCCAGG TGAGACAGCA CCCTCTATGC GACTGCTGGC CTATGCTTTC 
ATGACGCTGG TCATTATCTT GCTGCATGTA TTCTGGGGCA TTGTATTTTT TGATGGCTGT 
GAGAAGAAAA AGTGGGGCAT CCTCCTTATC GTTCTCCTGA CCCACCTGCT GGTGTCAGCC 
CAGACCTTCA TAAGTTCTTA TTATGGAATA AACCTGGCGT CAGCATTTAT AATCCTGGTG 
CTCATGGGCA CCTGGGCATT CTTAGCTGCG GGAGGCAGCT GCCGAAGCCT GAAACTCTGC 
CTGCTCTGCC AAGACAAGAA CTTTCTTCTT TACAACCAGC GCTCCAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APH1B ( XM_024450086.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305854.1 Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu104065
Clone ID Related Accession (Same CDS sequence)	XM_024450086.1 , XM_024450085.1
Accession Version	XM_024450086.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	gamma-secretase subunit APH-1B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAAGAG TCATTATTGA CAACAAAGAT GGACCAACAC AGAAATATCT GCTGATCTTT 
GGAGCGTTTG TCTCTGTCTA TATCCAAGAA ATGTTCCGAT TTGCATATTA TAAACTCTTA 
AAAAAAGCCA GTGAAGGTTT GAAGAGTATA AACCCAGGTG AGACAGCACC CTCTATGCGA 
CTGCTGGCCT ATGTTTCTGG CTTGGGCTTT GGAATCATGA GTGGAGTATT TTCCTTTGTG 
AATACCCTAT CTGACTCCTT GGGGCCAGGC ACAGTGGGCA TTCATGGAGA TTCTCCTCAA 
TTCTTCCTTT ATTCAGCTTT CATGACGCTG GTCATTATCT TGCTGCATGT ATTCTGGGGC 
ATTGTATTTT TTGATGGCTG TGAGAAGAAA AAGTGGGGCA TCCTCCTTAT CGTTCTCCTG 
ACCCACCTGC TGGTGTCAGC CCAGACCTTC ATAAGTTCTT ATTATGGAAT AAACCTGGCG 
TCAGCATTTA TAATCCTGGT GCTCATGGGC ACCTGGGCAT TCTTAGCTGC GGGAGGCAGC 
TGCCGAAGCC TGAAACTCTG CCTGCTCTGC CAAGACAAGA ACTTTCTTCT TTACAACCAG 
CGCTCCAGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305854.1
CDS	143..754
Translation	MARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKNFLLYNQRSR

Target ORF information:

RefSeq Version	XM_024450086.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024450086.1

ORF Insert Sequence:

ATGGCAAGAG TCATTATTGA CAACAAAGAT GGACCAACAC AGAAATATCT GCTGATCTTT 
GGAGCGTTTG TCTCTGTCTA TATCCAAGAA ATGTTCCGAT TTGCATATTA TAAACTCTTA 
AAAAAAGCCA GTGAAGGTTT GAAGAGTATA AACCCAGGTG AGACAGCACC CTCTATGCGA 
CTGCTGGCCT ATGTTTCTGG CTTGGGCTTT GGAATCATGA GTGGAGTATT TTCCTTTGTG 
AATACCCTAT CTGACTCCTT GGGGCCAGGC ACAGTGGGCA TTCATGGAGA TTCTCCTCAA 
TTCTTCCTTT ATTCAGCTTT CATGACGCTG GTCATTATCT TGCTGCATGT ATTCTGGGGC 
ATTGTATTTT TTGATGGCTG TGAGAAGAAA AAGTGGGGCA TCCTCCTTAT CGTTCTCCTG 
ACCCACCTGC TGGTGTCAGC CCAGACCTTC ATAAGTTCTT ATTATGGAAT AAACCTGGCG 
TCAGCATTTA TAATCCTGGT GCTCATGGGC ACCTGGGCAT TCTTAGCTGC GGGAGGCAGC 
TGCCGAAGCC TGAAACTCTG CCTGCTCTGC CAAGACAAGA ACTTTCTTCT TTACAACCAG 
CGCTCCAGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APH1B ( XM_024450085.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305853.1 Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu104065
Clone ID Related Accession (Same CDS sequence)	XM_024450086.1 , XM_024450085.1
Accession Version	XM_024450085.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	gamma-secretase subunit APH-1B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAAGAG TCATTATTGA CAACAAAGAT GGACCAACAC AGAAATATCT GCTGATCTTT 
GGAGCGTTTG TCTCTGTCTA TATCCAAGAA ATGTTCCGAT TTGCATATTA TAAACTCTTA 
AAAAAAGCCA GTGAAGGTTT GAAGAGTATA AACCCAGGTG AGACAGCACC CTCTATGCGA 
CTGCTGGCCT ATGTTTCTGG CTTGGGCTTT GGAATCATGA GTGGAGTATT TTCCTTTGTG 
AATACCCTAT CTGACTCCTT GGGGCCAGGC ACAGTGGGCA TTCATGGAGA TTCTCCTCAA 
TTCTTCCTTT ATTCAGCTTT CATGACGCTG GTCATTATCT TGCTGCATGT ATTCTGGGGC 
ATTGTATTTT TTGATGGCTG TGAGAAGAAA AAGTGGGGCA TCCTCCTTAT CGTTCTCCTG 
ACCCACCTGC TGGTGTCAGC CCAGACCTTC ATAAGTTCTT ATTATGGAAT AAACCTGGCG 
TCAGCATTTA TAATCCTGGT GCTCATGGGC ACCTGGGCAT TCTTAGCTGC GGGAGGCAGC 
TGCCGAAGCC TGAAACTCTG CCTGCTCTGC CAAGACAAGA ACTTTCTTCT TTACAACCAG 
CGCTCCAGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305853.1
CDS	187..798
Translation	MARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKNFLLYNQRSR

Target ORF information:

RefSeq Version	XM_024450085.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024450085.1

ORF Insert Sequence:

ATGGCAAGAG TCATTATTGA CAACAAAGAT GGACCAACAC AGAAATATCT GCTGATCTTT 
GGAGCGTTTG TCTCTGTCTA TATCCAAGAA ATGTTCCGAT TTGCATATTA TAAACTCTTA 
AAAAAAGCCA GTGAAGGTTT GAAGAGTATA AACCCAGGTG AGACAGCACC CTCTATGCGA 
CTGCTGGCCT ATGTTTCTGG CTTGGGCTTT GGAATCATGA GTGGAGTATT TTCCTTTGTG 
AATACCCTAT CTGACTCCTT GGGGCCAGGC ACAGTGGGCA TTCATGGAGA TTCTCCTCAA 
TTCTTCCTTT ATTCAGCTTT CATGACGCTG GTCATTATCT TGCTGCATGT ATTCTGGGGC 
ATTGTATTTT TTGATGGCTG TGAGAAGAAA AAGTGGGGCA TCCTCCTTAT CGTTCTCCTG 
ACCCACCTGC TGGTGTCAGC CCAGACCTTC ATAAGTTCTT ATTATGGAAT AAACCTGGCG 
TCAGCATTTA TAATCCTGGT GCTCATGGGC ACCTGGGCAT TCTTAGCTGC GGGAGGCAGC 
TGCCGAAGCC TGAAACTCTG CCTGCTCTGC CAAGACAAGA ACTTTCTTCT TTACAACCAG 
CGCTCCAGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APH1B ( XM_011522105.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520407.1 Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu73063
Clone ID Related Accession (Same CDS sequence)	XM_011522105.3 , XM_011522105.2
Accession Version	XM_011522105.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	gamma-secretase subunit APH-1B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011522105.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGCGG CCGTGTTCTT CGGCTGCGCC TTCATTGCCT TCGGGCCTGC GCTCGCCCTT 
TATGTCTTCA CCATCGCCAC CGAGCCGTTG CGTATCATCT TCCTCATCGC CGGAGCTTTC 
TTCTGGTTGG TGTCTCTACT GATTTCGTCC CTTGTTTGGT TCATGGCAAG AGTCATTATT 
GACAACAAAG ATGGACCAAC ACAGAAATAT CTGCTGATCT TTGGAGCGTT TGTCTCTGTC 
TATATCCAAG AAATGTTCCG ATTTGCATAT TATAAACTCT TAAAAAAAGC CAGTGAAGGT 
TTGAAGAGTA TAAACCCAGG TGAGACAGCA CCCTCTATGC GACTGCTGGC CTATGTTTCT 
GGCTTGGGCT TTGGAATCAT GAGTGGAGTA TTTTCCTTTG TGAATACCCT ATCTGACTCC 
TTGGGGCCAG GCACAGTGGG CATTCATGGA GATTCTCCTC AATTCTTCCT TTATTCAGCT 
TTCATGACGC TGGTCATTAT CTTGCTGCAT GTATTCTGGG GCATTGTATT TTTTGATGGC 
TGTGAGAAGA AAAAGTGGGG CATCCTCCTT ATCGTTCTCC TGACCCACCT GCTGGTGTCA 
GCCCAGGTCA GTTTGGAAAA CTGTTCATTC TCTGTGACAG CTGCGTGGAA AAGTTGCGTA 
TTCCAGACTC GGCACCATGA CTGGACCTTA TTCCTAGCTC TCGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520407.1
CDS	75..782
Translation	MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQVSLENCSFSVTAAWKSCVFQTRHHDWTLFLALV

Target ORF information:

RefSeq Version	XM_011522105.3
Organism	Homo sapiens(human)
Definition	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522105.3

ORF Insert Sequence:

ATGACTGCGG CCGTGTTCTT CGGCTGCGCC TTCATTGCCT TCGGGCCTGC GCTCGCCCTT 
TATGTCTTCA CCATCGCCAC CGAGCCGTTG CGTATCATCT TCCTCATCGC CGGAGCTTTC 
TTCTGGTTGG TGTCTCTACT GATTTCGTCC CTTGTTTGGT TCATGGCAAG AGTCATTATT 
GACAACAAAG ATGGACCAAC ACAGAAATAT CTGCTGATCT TTGGAGCGTT TGTCTCTGTC 
TATATCCAAG AAATGTTCCG ATTTGCATAT TATAAACTCT TAAAAAAAGC CAGTGAAGGT 
TTGAAGAGTA TAAACCCAGG TGAGACAGCA CCCTCTATGC GACTGCTGGC CTATGTTTCT 
GGCTTGGGCT TTGGAATCAT GAGTGGAGTA TTTTCCTTTG TGAATACCCT ATCTGACTCC 
TTGGGGCCAG GCACAGTGGG CATTCATGGA GATTCTCCTC AATTCTTCCT TTATTCAGCT 
TTCATGACGC TGGTCATTAT CTTGCTGCAT GTATTCTGGG GCATTGTATT TTTTGATGGC 
TGTGAGAAGA AAAAGTGGGG CATCCTCCTT ATCGTTCTCC TGACCCACCT GCTGGTGTCA 
GCCCAGGTCA GTTTGGAAAA CTGTTCATTC TCTGTGACAG CTGCGTGGAA AAGTTGCGTA 
TTCCAGACTC GGCACCATGA CTGGACCTTA TTCCTAGCTC TCGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APH1B ( XM_011522105.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520407.1 Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu73063
Clone ID Related Accession (Same CDS sequence)	XM_011522105.3 , XM_011522105.2
Accession Version	XM_011522105.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	gamma-secretase subunit APH-1B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011522105.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGCGG CCGTGTTCTT CGGCTGCGCC TTCATTGCCT TCGGGCCTGC GCTCGCCCTT 
TATGTCTTCA CCATCGCCAC CGAGCCGTTG CGTATCATCT TCCTCATCGC CGGAGCTTTC 
TTCTGGTTGG TGTCTCTACT GATTTCGTCC CTTGTTTGGT TCATGGCAAG AGTCATTATT 
GACAACAAAG ATGGACCAAC ACAGAAATAT CTGCTGATCT TTGGAGCGTT TGTCTCTGTC 
TATATCCAAG AAATGTTCCG ATTTGCATAT TATAAACTCT TAAAAAAAGC CAGTGAAGGT 
TTGAAGAGTA TAAACCCAGG TGAGACAGCA CCCTCTATGC GACTGCTGGC CTATGTTTCT 
GGCTTGGGCT TTGGAATCAT GAGTGGAGTA TTTTCCTTTG TGAATACCCT ATCTGACTCC 
TTGGGGCCAG GCACAGTGGG CATTCATGGA GATTCTCCTC AATTCTTCCT TTATTCAGCT 
TTCATGACGC TGGTCATTAT CTTGCTGCAT GTATTCTGGG GCATTGTATT TTTTGATGGC 
TGTGAGAAGA AAAAGTGGGG CATCCTCCTT ATCGTTCTCC TGACCCACCT GCTGGTGTCA 
GCCCAGGTCA GTTTGGAAAA CTGTTCATTC TCTGTGACAG CTGCGTGGAA AAGTTGCGTA 
TTCCAGACTC GGCACCATGA CTGGACCTTA TTCCTAGCTC TCGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520407.1
CDS	106..813
Translation	MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQVSLENCSFSVTAAWKSCVFQTRHHDWTLFLALV

Target ORF information:

RefSeq Version	XM_011522105.2
Organism	Homo sapiens(human)
Definition	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522105.2

ORF Insert Sequence:

ATGACTGCGG CCGTGTTCTT CGGCTGCGCC TTCATTGCCT TCGGGCCTGC GCTCGCCCTT 
TATGTCTTCA CCATCGCCAC CGAGCCGTTG CGTATCATCT TCCTCATCGC CGGAGCTTTC 
TTCTGGTTGG TGTCTCTACT GATTTCGTCC CTTGTTTGGT TCATGGCAAG AGTCATTATT 
GACAACAAAG ATGGACCAAC ACAGAAATAT CTGCTGATCT TTGGAGCGTT TGTCTCTGTC 
TATATCCAAG AAATGTTCCG ATTTGCATAT TATAAACTCT TAAAAAAAGC CAGTGAAGGT 
TTGAAGAGTA TAAACCCAGG TGAGACAGCA CCCTCTATGC GACTGCTGGC CTATGTTTCT 
GGCTTGGGCT TTGGAATCAT GAGTGGAGTA TTTTCCTTTG TGAATACCCT ATCTGACTCC 
TTGGGGCCAG GCACAGTGGG CATTCATGGA GATTCTCCTC AATTCTTCCT TTATTCAGCT 
TTCATGACGC TGGTCATTAT CTTGCTGCAT GTATTCTGGG GCATTGTATT TTTTGATGGC 
TGTGAGAAGA AAAAGTGGGG CATCCTCCTT ATCGTTCTCC TGACCCACCT GCTGGTGTCA 
GCCCAGGTCA GTTTGGAAAA CTGTTCATTC TCTGTGACAG CTGCGTGGAA AAGTTGCGTA 
TTCCAGACTC GGCACCATGA CTGGACCTTA TTCCTAGCTC TCGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APH1B ( NM_031301.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_112591.2 Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant 1, mRNA.

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CloneID	OHu23746
Clone ID Related Accession (Same CDS sequence)	NM_031301.3 , NM_031301.4
Accession Version	NM_031301.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	gamma-secretase subunit APH-1B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA397427.1, AK291204.1, AC016207.9 and AI693802.1. On Mar 5, 2009 this sequence version replaced NM_031301.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.259640.1, SRR1660809.175995.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGACTGCGG CCGTGTTCTT CGGCTGCGCC TTCATTGCCT TCGGGCCTGC GCTCGCCCTT 
TATGTCTTCA CCATCGCCAC CGAGCCGTTG CGTATCATCT TCCTCATCGC CGGAGCTTTC 
TTCTGGTTGG TGTCTCTACT GATTTCGTCC CTTGTTTGGT TCATGGCAAG AGTCATTATT 
GACAACAAAG ATGGACCAAC ACAGAAATAT CTGCTGATCT TTGGAGCGTT TGTCTCTGTC 
TATATCCAAG AAATGTTCCG ATTTGCATAT TATAAACTCT TAAAAAAAGC CAGTGAAGGT 
TTGAAGAGTA TAAACCCAGG TGAGACAGCA CCCTCTATGC GACTGCTGGC CTATGTTTCT 
GGCTTGGGCT TTGGAATCAT GAGTGGAGTA TTTTCCTTTG TGAATACCCT ATCTGACTCC 
TTGGGGCCAG GCACAGTGGG CATTCATGGA GATTCTCCTC AATTCTTCCT TTATTCAGCT 
TTCATGACGC TGGTCATTAT CTTGCTGCAT GTATTCTGGG GCATTGTATT TTTTGATGGC 
TGTGAGAAGA AAAAGTGGGG CATCCTCCTT ATCGTTCTCC TGACCCACCT GCTGGTGTCA 
GCCCAGACCT TCATAAGTTC TTATTATGGA ATAAACCTGG CGTCAGCATT TATAATCCTG 
GTGCTCATGG GCACCTGGGC ATTCTTAGCT GCGGGAGGCA GCTGCCGAAG CCTGAAACTC 
TGCCTGCTCT GCCAAGACAA GAACTTTCTT CTTTACAACC AGCGCTCCAG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112591.2
CDS	75..848
Translation	MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKNFLLYNQRSR

Target ORF information:

RefSeq Version	NM_031301.3
Organism	Homo sapiens(human)
Definition	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031301.3

ORF Insert Sequence:

ATGACTGCGG CCGTGTTCTT CGGCTGCGCC TTCATTGCCT TCGGGCCTGC GCTCGCCCTT 
TATGTCTTCA CCATCGCCAC CGAGCCGTTG CGTATCATCT TCCTCATCGC CGGAGCTTTC 
TTCTGGTTGG TGTCTCTACT GATTTCGTCC CTTGTTTGGT TCATGGCAAG AGTCATTATT 
GACAACAAAG ATGGACCAAC ACAGAAATAT CTGCTGATCT TTGGAGCGTT TGTCTCTGTC 
TATATCCAAG AAATGTTCCG ATTTGCATAT TATAAACTCT TAAAAAAAGC CAGTGAAGGT 
TTGAAGAGTA TAAACCCAGG TGAGACAGCA CCCTCTATGC GACTGCTGGC CTATGTTTCT 
GGCTTGGGCT TTGGAATCAT GAGTGGAGTA TTTTCCTTTG TGAATACCCT ATCTGACTCC 
TTGGGGCCAG GCACAGTGGG CATTCATGGA GATTCTCCTC AATTCTTCCT TTATTCAGCT 
TTCATGACGC TGGTCATTAT CTTGCTGCAT GTATTCTGGG GCATTGTATT TTTTGATGGC 
TGTGAGAAGA AAAAGTGGGG CATCCTCCTT ATCGTTCTCC TGACCCACCT GCTGGTGTCA 
GCCCAGACCT TCATAAGTTC TTATTATGGA ATAAACCTGG CGTCAGCATT TATAATCCTG 
GTGCTCATGG GCACCTGGGC ATTCTTAGCT GCGGGAGGCA GCTGCCGAAG CCTGAAACTC 
TGCCTGCTCT GCCAAGACAA GAACTTTCTT CTTTACAACC AGCGCTCCAG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APH1B ( NM_031301.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_112591.2 Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23746
Clone ID Related Accession (Same CDS sequence)	NM_031301.3 , NM_031301.4
Accession Version	NM_031301.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573833600000
Organism	Homo sapiens(human)
Product	gamma-secretase subunit APH-1B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA397427.1, AK291204.1, AC016207.9 and AI693802.1. On Nov 22, 2018 this sequence version replaced NM_031301.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.158726.1, SRR1660809.186662.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261879.10/ ENSP00000261879.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTGCGG CCGTGTTCTT CGGCTGCGCC TTCATTGCCT TCGGGCCTGC GCTCGCCCTT 
TATGTCTTCA CCATCGCCAC CGAGCCGTTG CGTATCATCT TCCTCATCGC CGGAGCTTTC 
TTCTGGTTGG TGTCTCTACT GATTTCGTCC CTTGTTTGGT TCATGGCAAG AGTCATTATT 
GACAACAAAG ATGGACCAAC ACAGAAATAT CTGCTGATCT TTGGAGCGTT TGTCTCTGTC 
TATATCCAAG AAATGTTCCG ATTTGCATAT TATAAACTCT TAAAAAAAGC CAGTGAAGGT 
TTGAAGAGTA TAAACCCAGG TGAGACAGCA CCCTCTATGC GACTGCTGGC CTATGTTTCT 
GGCTTGGGCT TTGGAATCAT GAGTGGAGTA TTTTCCTTTG TGAATACCCT ATCTGACTCC 
TTGGGGCCAG GCACAGTGGG CATTCATGGA GATTCTCCTC AATTCTTCCT TTATTCAGCT 
TTCATGACGC TGGTCATTAT CTTGCTGCAT GTATTCTGGG GCATTGTATT TTTTGATGGC 
TGTGAGAAGA AAAAGTGGGG CATCCTCCTT ATCGTTCTCC TGACCCACCT GCTGGTGTCA 
GCCCAGACCT TCATAAGTTC TTATTATGGA ATAAACCTGG CGTCAGCATT TATAATCCTG 
GTGCTCATGG GCACCTGGGC ATTCTTAGCT GCGGGAGGCA GCTGCCGAAG CCTGAAACTC 
TGCCTGCTCT GCCAAGACAA GAACTTTCTT CTTTACAACC AGCGCTCCAG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112591.2
CDS	20..793
Translation	MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKNFLLYNQRSR

Target ORF information:

RefSeq Version	NM_031301.4
Organism	Homo sapiens(human)
Definition	Homo sapiens aph-1 homolog B, gamma-secretase subunit (APH1B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031301.4

ORF Insert Sequence:

ATGACTGCGG CCGTGTTCTT CGGCTGCGCC TTCATTGCCT TCGGGCCTGC GCTCGCCCTT 
TATGTCTTCA CCATCGCCAC CGAGCCGTTG CGTATCATCT TCCTCATCGC CGGAGCTTTC 
TTCTGGTTGG TGTCTCTACT GATTTCGTCC CTTGTTTGGT TCATGGCAAG AGTCATTATT 
GACAACAAAG ATGGACCAAC ACAGAAATAT CTGCTGATCT TTGGAGCGTT TGTCTCTGTC 
TATATCCAAG AAATGTTCCG ATTTGCATAT TATAAACTCT TAAAAAAAGC CAGTGAAGGT 
TTGAAGAGTA TAAACCCAGG TGAGACAGCA CCCTCTATGC GACTGCTGGC CTATGTTTCT 
GGCTTGGGCT TTGGAATCAT GAGTGGAGTA TTTTCCTTTG TGAATACCCT ATCTGACTCC 
TTGGGGCCAG GCACAGTGGG CATTCATGGA GATTCTCCTC AATTCTTCCT TTATTCAGCT 
TTCATGACGC TGGTCATTAT CTTGCTGCAT GTATTCTGGG GCATTGTATT TTTTGATGGC 
TGTGAGAAGA AAAAGTGGGG CATCCTCCTT ATCGTTCTCC TGACCCACCT GCTGGTGTCA 
GCCCAGACCT TCATAAGTTC TTATTATGGA ATAAACCTGG CGTCAGCATT TATAATCCTG 
GTGCTCATGG GCACCTGGGC ATTCTTAGCT GCGGGAGGCA GCTGCCGAAG CCTGAAACTC 
TGCCTGCTCT GCCAAGACAA GAACTTTCTT CTTTACAACC AGCGCTCCAG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
Biochemical and biophysical research communications478(4)1751-7(2016 09)
Yonemura Y,Futai E,Yagishita S,Kaether C,Ishiura S

Imatinib methanesulfonate reduces hippocampal amyloid-β and restores cognitive function following repeated endotoxin exposure.
Brain, behavior, and immunity3324-8(2013 Oct)
Weintraub MK,Bisson CM,Nouri JN,Vinson BT,Eimerbrink MJ,Kranjac D,Boehm GW,Chumley MJ

Correlation between HIV-1 seropositivity and prevalence of a gamma-secretase polymorphism in two distinct ethnic populations.
Journal of medical virology81(11)1847-51(2009 Nov)
van Loo KM,van Schijndel JE,van Zweeden M,van Manen D,Trip MD,Petersen DC,Schuitemaker H,Hayes VM,Martens GJ

Male-specific association between a gamma-secretase polymorphism and premature coronary atherosclerosis.
PloS one3(11)e3662(2008)
van Loo KM,Dejaegere T,van Zweeden M,van Schijndel JE,Wijmenga C,Trip MD,Martens GJ

Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?
Journal of neurochemistry103 Suppl 191-100(2007 Nov)
Bronfman FC

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APH1B cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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