INO80B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	INO80B
Entrez Gene ID	83444
Full Name	INO80 complex subunit B
Synonyms	HMGA1L4,HMGIYL4,IES2,PAP-1BP,PAPA-1,PAPA1,ZNHIT4,hIes2
General protein information	Preferred Names INO80 complex subunit B Names INO80 complex subunit B IES2 homolog PAP (Pim-1 associated protein) associated protein 1 PAP-1 binding protein PAP-1-associated protein 1 high mobility group AT-hook 1-like 4 zinc finger HIT domain-containing protein 4 zinc finger, HIT type 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.1
Summary	This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. [provided by RefSeq, Feb 2011].
Disorder MIM:	616456

mRNA and Protein(s)

mRNA	Protein	Name
NM_031288.4	NP_112578.2	INO80 complex subunit B
NM_031288.3	NP_112578.2	INO80 complex subunit B

Pathways from BioSystems

Homologies

Homo sapiens (human)	INO80B	NP_112578.2
Pan troglodytes (chimpanzee)	INO80B	XP_001158449.1
Danio rerio (zebrafish)	ino80b	NP_001070726.1
Xenopus tropicalis (tropical clawed frog)	LOC100216277	NP_001135702.1
Canis lupus familiaris (dog)	INO80B	XP_540221.3
Bos taurus (cattle)	INO80B	NP_001098817.1
Macaca mulatta (Rhesus monkey)	LOC709107	XP_001109793.2
Mus musculus (house mouse)	Ino80b	NP_076036.1
Rattus norvegicus (Norway rat)	Ino80b	NP_001041698.1

Gene Ontology
Bibliography

Related articles in PubMed

Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia.
Oudejans CB, Michel OJ, Janssen R, Habets R, Poutsma A, Sistermans EA, Weiss MM, Incarnato D, Oliviero S, Kleiverda G, Van Dijk M, Arngrímsson R
Human molecular genetics24(1)118-27(2015 Jan)

Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.
Chen L, Cai Y, Jin J, Florens L, Swanson SK, Washburn MP, Conaway JW, Conaway RC
The Journal of biological chemistry286(13)11283-9(2011 Apr)

PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions.
Miyako K, Cobb LJ, Francis M, Huang A, Peng B, Pintar JE, Ariga H, Cohen P
Molecular endocrinology (Baltimore, Md.)23(2)169-75(2009 Feb)

A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.
Jin J, Cai Y, Yao T, Gottschalk AJ, Florens L, Swanson SK, Gutiérrez JL, Coleman MK, Workman JL, Mushegian A, Washburn MP, Conaway RC, Conaway JW
The Journal of biological chemistry280(50)41207-12(2005 Dec)

A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase.
Kuroda TS, Maita H, Tabata T, Taira T, Kitaura H, Ariga H, Iguchi-Ariga SM
Gene340(1)83-98(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following INO80B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the INO80B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55775	NM_031288.4 Latest version!	Homo sapiens INO80 complex subunit B (INO80B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu55775	NM_031288.3	Homo sapiens INO80 complex subunit B (INO80B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

INO80B ( NM_031288.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_112578.2 Homo sapiens INO80 complex subunit B (INO80B), mRNA.

Price & Availability↑

CloneID	OHu55775
Clone ID Related Accession (Same CDS sequence)	NM_031288.4 , NM_031288.3
Accession Version	NM_031288.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	INO80 complex subunit B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB451812.1 and BC064425.1. On Nov 22, 2018 this sequence version replaced NM_031288.3. ##Evidence-Data-START## Transcript exon combination :: BC064425.1, ERR279845.3562.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000233331.12/ ENSP00000233331.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTAAGC TGTGGCGGCG TGGGAGCACC TCTGGGGCTA TGGAGGCCCC TGAGCCGGGA 
GAAGCCCTGG AGTTGAGCCT GGCGGGTGCC CATGGCCATG GAGTGCACAA GAAAAAACAC 
AAGAAGCACA AGAAGAAACA CAAGAAGAAA CACCATCAGG AAGAAGACGC CGGGCCCACG 
CAGCCGTCCC CTGCCAAGCC TCAGCTCAAA CTCAAAATCA AGCTTGGGGG ACAAGTCCTG 
GGGACCAAGA GTGTTCCTAC CTTCACTGTG ATCCCAGAGG GGCCTCGCTC ACCCTCTCCC 
CTTATGGTTG TGGATAATGA AGAGGAACCT ATGGAAGGAG TCCCCCTTGA GCAGTACCGT 
GCCTGGCTGG ATGAAGACAG TAATCTCTCT CCCTCTCCAC TTCGGGACCT ATCAGGAGGG 
TTAGGGGGTC AGGAGGAAGA GGAGGAACAG AGGTGGCTGG ATGCCCTGGA GAAGGGGGAG 
CTGGATGACA ATGGAGACCT CAAGAAGGAG ATCAATGAGC GGCTGCTTAC TGCTCGACAG 
CGAGCTCTGC TCCAGAAGGC GCGGAGTCAA CCTTCCCCTA TGCTGCCGCT GCCTGTAGCT 
GAGGGCTGCC CACCTCCCGC CCTCACAGAG GAGATGCTGC TGAAGCGCGA GGAGCGGGCG 
CGGAAGCGGC GGCTCCAGGC GGCGCGGCGG GCAGAAGAGC ACAAGAACCA GACTATCGAG 
CGCCTCACCA AGACTGCGGC GACCAGTGGG CGGGGAGGCC GGGGGGGCGC ACGGGGCGAG 
CGGCGGGGAG GGCGGGCTGC GGCTCCGGCC CCCATGGTGC GCTACTGCAG CGGAGCACAG 
GGTTCCACCC TTTCCTTCCC ACCTGGCGTC CCCGCCCCCA CGGCAGTGTC TCAGCGGCCA 
TCCCCCTCAG GCCCGCCGCC GCGCTGCTCT GTCCCCGGCT GTCCCCATCC GCGCCGCTAC 
GCTTGCTCCC GCACAGGCCA GGCACTCTGT AGTCTTCAGT GCTACCGCAT CAACCTGCAG 
ATGCGGCTGG GGGGGCCCGA GGGTCCTGGA TCCCCCCTTT TGGCTACGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112578.2
CDS	31..1101
Translation	MSKLWRRGSTSGAMEAPEPGEALELSLAGAHGHGVHKKKHKKHKKKHKKKHHQEEDAGPTQPSPAKPQLKLKIKLGGQVLGTKSVPTFTVIPEGPRSPSPLMVVDNEEEPMEGVPLEQYRAWLDEDSNLSPSPLRDLSGGLGGQEEEEEQRWLDALEKGELDDNGDLKKEINERLLTARQRALLQKARSQPSPMLPLPVAEGCPPPALTEEMLLKREERARKRRLQAARRAEEHKNQTIERLTKTAATSGRGGRGGARGERRGGRAAAPAPMVRYCSGAQGSTLSFPPGVPAPTAVSQRPSPSGPPPRCSVPGCPHPRRYACSRTGQALCSLQCYRINLQMRLGGPEGPGSPLLAT

Target ORF information:

RefSeq Version	NM_031288.4
Organism	Homo sapiens(human)
Definition	Homo sapiens INO80 complex subunit B (INO80B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031288.4

ORF Insert Sequence:

ATGAGTAAGC TGTGGCGGCG TGGGAGCACC TCTGGGGCTA TGGAGGCCCC TGAGCCGGGA 
GAAGCCCTGG AGTTGAGCCT GGCGGGTGCC CATGGCCATG GAGTGCACAA GAAAAAACAC 
AAGAAGCACA AGAAGAAACA CAAGAAGAAA CACCATCAGG AAGAAGACGC CGGGCCCACG 
CAGCCGTCCC CTGCCAAGCC TCAGCTCAAA CTCAAAATCA AGCTTGGGGG ACAAGTCCTG 
GGGACCAAGA GTGTTCCTAC CTTCACTGTG ATCCCAGAGG GGCCTCGCTC ACCCTCTCCC 
CTTATGGTTG TGGATAATGA AGAGGAACCT ATGGAAGGAG TCCCCCTTGA GCAGTACCGT 
GCCTGGCTGG ATGAAGACAG TAATCTCTCT CCCTCTCCAC TTCGGGACCT ATCAGGAGGG 
TTAGGGGGTC AGGAGGAAGA GGAGGAACAG AGGTGGCTGG ATGCCCTGGA GAAGGGGGAG 
CTGGATGACA ATGGAGACCT CAAGAAGGAG ATCAATGAGC GGCTGCTTAC TGCTCGACAG 
CGAGCTCTGC TCCAGAAGGC GCGGAGTCAA CCTTCCCCTA TGCTGCCGCT GCCTGTAGCT 
GAGGGCTGCC CACCTCCCGC CCTCACAGAG GAGATGCTGC TGAAGCGCGA GGAGCGGGCG 
CGGAAGCGGC GGCTCCAGGC GGCGCGGCGG GCAGAAGAGC ACAAGAACCA GACTATCGAG 
CGCCTCACCA AGACTGCGGC GACCAGTGGG CGGGGAGGCC GGGGGGGCGC ACGGGGCGAG 
CGGCGGGGAG GGCGGGCTGC GGCTCCGGCC CCCATGGTGC GCTACTGCAG CGGAGCACAG 
GGTTCCACCC TTTCCTTCCC ACCTGGCGTC CCCGCCCCCA CGGCAGTGTC TCAGCGGCCA 
TCCCCCTCAG GCCCGCCGCC GCGCTGCTCT GTCCCCGGCT GTCCCCATCC GCGCCGCTAC 
GCTTGCTCCC GCACAGGCCA GGCACTCTGT AGTCTTCAGT GCTACCGCAT CAACCTGCAG 
ATGCGGCTGG GGGGGCCCGA GGGTCCTGGA TCCCCCCTTT TGGCTACGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

INO80B ( NM_031288.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_112578.2 Homo sapiens INO80 complex subunit B (INO80B), mRNA.

Price & Availability↑

CloneID	OHu55775
Clone ID Related Accession (Same CDS sequence)	NM_031288.4 , NM_031288.3
Accession Version	NM_031288.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	INO80 complex subunit B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB451812.1, BC064425.1 and AI978697.1. On Feb 11, 2011 this sequence version replaced NM_031288.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.546565.1, SRR1163658.167847.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTAAGC TGTGGCGGCG TGGGAGCACC TCTGGGGCTA TGGAGGCCCC TGAGCCGGGA 
GAAGCCCTGG AGTTGAGCCT GGCGGGTGCC CATGGCCATG GAGTGCACAA GAAAAAACAC 
AAGAAGCACA AGAAGAAACA CAAGAAGAAA CACCATCAGG AAGAAGACGC CGGGCCCACG 
CAGCCGTCCC CTGCCAAGCC TCAGCTCAAA CTCAAAATCA AGCTTGGGGG ACAAGTCCTG 
GGGACCAAGA GTGTTCCTAC CTTCACTGTG ATCCCAGAGG GGCCTCGCTC ACCCTCTCCC 
CTTATGGTTG TGGATAATGA AGAGGAACCT ATGGAAGGAG TCCCCCTTGA GCAGTACCGT 
GCCTGGCTGG ATGAAGACAG TAATCTCTCT CCCTCTCCAC TTCGGGACCT ATCAGGAGGG 
TTAGGGGGTC AGGAGGAAGA GGAGGAACAG AGGTGGCTGG ATGCCCTGGA GAAGGGGGAG 
CTGGATGACA ATGGAGACCT CAAGAAGGAG ATCAATGAGC GGCTGCTTAC TGCTCGACAG 
CGAGCTCTGC TCCAGAAGGC GCGGAGTCAA CCTTCCCCTA TGCTGCCGCT GCCTGTAGCT 
GAGGGCTGCC CACCTCCCGC CCTCACAGAG GAGATGCTGC TGAAGCGCGA GGAGCGGGCG 
CGGAAGCGGC GGCTCCAGGC GGCGCGGCGG GCAGAAGAGC ACAAGAACCA GACTATCGAG 
CGCCTCACCA AGACTGCGGC GACCAGTGGG CGGGGAGGCC GGGGGGGCGC ACGGGGCGAG 
CGGCGGGGAG GGCGGGCTGC GGCTCCGGCC CCCATGGTGC GCTACTGCAG CGGAGCACAG 
GGTTCCACCC TTTCCTTCCC ACCTGGCGTC CCCGCCCCCA CGGCAGTGTC TCAGCGGCCA 
TCCCCCTCAG GCCCGCCGCC GCGCTGCTCT GTCCCCGGCT GTCCCCATCC GCGCCGCTAC 
GCTTGCTCCC GCACAGGCCA GGCACTCTGT AGTCTTCAGT GCTACCGCAT CAACCTGCAG 
ATGCGGCTGG GGGGGCCCGA GGGTCCTGGA TCCCCCCTTT TGGCTACGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112578.2
CDS	95..1165
Translation	MSKLWRRGSTSGAMEAPEPGEALELSLAGAHGHGVHKKKHKKHKKKHKKKHHQEEDAGPTQPSPAKPQLKLKIKLGGQVLGTKSVPTFTVIPEGPRSPSPLMVVDNEEEPMEGVPLEQYRAWLDEDSNLSPSPLRDLSGGLGGQEEEEEQRWLDALEKGELDDNGDLKKEINERLLTARQRALLQKARSQPSPMLPLPVAEGCPPPALTEEMLLKREERARKRRLQAARRAEEHKNQTIERLTKTAATSGRGGRGGARGERRGGRAAAPAPMVRYCSGAQGSTLSFPPGVPAPTAVSQRPSPSGPPPRCSVPGCPHPRRYACSRTGQALCSLQCYRINLQMRLGGPEGPGSPLLAT

Target ORF information:

RefSeq Version	NM_031288.3
Organism	Homo sapiens(human)
Definition	Homo sapiens INO80 complex subunit B (INO80B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031288.3

ORF Insert Sequence:

ATGAGTAAGC TGTGGCGGCG TGGGAGCACC TCTGGGGCTA TGGAGGCCCC TGAGCCGGGA 
GAAGCCCTGG AGTTGAGCCT GGCGGGTGCC CATGGCCATG GAGTGCACAA GAAAAAACAC 
AAGAAGCACA AGAAGAAACA CAAGAAGAAA CACCATCAGG AAGAAGACGC CGGGCCCACG 
CAGCCGTCCC CTGCCAAGCC TCAGCTCAAA CTCAAAATCA AGCTTGGGGG ACAAGTCCTG 
GGGACCAAGA GTGTTCCTAC CTTCACTGTG ATCCCAGAGG GGCCTCGCTC ACCCTCTCCC 
CTTATGGTTG TGGATAATGA AGAGGAACCT ATGGAAGGAG TCCCCCTTGA GCAGTACCGT 
GCCTGGCTGG ATGAAGACAG TAATCTCTCT CCCTCTCCAC TTCGGGACCT ATCAGGAGGG 
TTAGGGGGTC AGGAGGAAGA GGAGGAACAG AGGTGGCTGG ATGCCCTGGA GAAGGGGGAG 
CTGGATGACA ATGGAGACCT CAAGAAGGAG ATCAATGAGC GGCTGCTTAC TGCTCGACAG 
CGAGCTCTGC TCCAGAAGGC GCGGAGTCAA CCTTCCCCTA TGCTGCCGCT GCCTGTAGCT 
GAGGGCTGCC CACCTCCCGC CCTCACAGAG GAGATGCTGC TGAAGCGCGA GGAGCGGGCG 
CGGAAGCGGC GGCTCCAGGC GGCGCGGCGG GCAGAAGAGC ACAAGAACCA GACTATCGAG 
CGCCTCACCA AGACTGCGGC GACCAGTGGG CGGGGAGGCC GGGGGGGCGC ACGGGGCGAG 
CGGCGGGGAG GGCGGGCTGC GGCTCCGGCC CCCATGGTGC GCTACTGCAG CGGAGCACAG 
GGTTCCACCC TTTCCTTCCC ACCTGGCGTC CCCGCCCCCA CGGCAGTGTC TCAGCGGCCA 
TCCCCCTCAG GCCCGCCGCC GCGCTGCTCT GTCCCCGGCT GTCCCCATCC GCGCCGCTAC 
GCTTGCTCCC GCACAGGCCA GGCACTCTGT AGTCTTCAGT GCTACCGCAT CAACCTGCAG 
ATGCGGCTGG GGGGGCCCGA GGGTCCTGGA TCCCCCCTTT TGGCTACGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia.
Human molecular genetics24(1)118-27(2015 Jan)
Oudejans CB,Michel OJ,Janssen R,Habets R,Poutsma A,Sistermans EA,Weiss MM,Incarnato D,Oliviero S,Kleiverda G,Van Dijk M,Arngrímsson R

Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.
The Journal of biological chemistry286(13)11283-9(2011 Apr)
Chen L,Cai Y,Jin J,Florens L,Swanson SK,Washburn MP,Conaway JW,Conaway RC

PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions.
Molecular endocrinology (Baltimore, Md.)23(2)169-75(2009 Feb)
Miyako K,Cobb LJ,Francis M,Huang A,Peng B,Pintar JE,Ariga H,Cohen P

A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.
The Journal of biological chemistry280(50)41207-12(2005 Dec)
Jin J,Cai Y,Yao T,Gottschalk AJ,Florens L,Swanson SK,Gutiérrez JL,Coleman MK,Workman JL,Mushegian A,Washburn MP,Conaway RC,Conaway JW

A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase.
Gene340(1)83-98(2004 Sep)
Kuroda TS,Maita H,Tabata T,Taira T,Kitaura H,Ariga H,Iguchi-Ariga SM

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INO80B cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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