GAN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GAN
Entrez Gene ID	8139
Full Name	gigaxonin
Synonyms	GAN1,KLHL16
General protein information	Preferred Names gigaxonin Names gigaxonin kelch-like family member 16 kelch-like protein 16
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q23.2
Summary	This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008].
Disorder MIM:	605379
Disorder Html:	Giant axonal neuropathy-1, 256850 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_022041.3	NP_071324.1	gigaxonin
XM_017023734.1	XP_016879223.1	gigaxonin isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gan	NP_001100904.1
Gallus gallus (chicken)	GAN	XP_428110.3
Pan troglodytes (chimpanzee)	GAN	XP_001142931.2
Macaca mulatta (Rhesus monkey)	GAN	XP_001111517.1
Bos taurus (cattle)	GAN	NP_001092485.1
Xenopus tropicalis (tropical clawed frog)	gan	NP_001016530.1
Homo sapiens (human)	GAN	NP_071324.1
Canis lupus familiaris (dog)	GAN	XP_546814.1
Mus musculus (house mouse)	Gan	NP_001074620.1
Danio rerio (zebrafish)	LOC100537435	XP_003200482.2

Gene Ontology
Bibliography

Related articles in PubMed

KLHL16 Degrades Epidermal Keratins.
Büchau F, Munz C, Has C, Lehmann R, Magin TM
The Journal of investigative dermatology138(8)1871-1873(2018 08)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Novel homozygous missense mutation in GAN associated with Charcot-Marie-Tooth disease type 2 in a large consanguineous family from Israel.
Aharoni S, Barwick KE, Straussberg R, Harlalka GV, Nevo Y, Chioza BA, McEntagart MM, Mimouni-Bloch A, Weedon M, Crosby AH
BMC medical genetics17(1)82(2016 Nov)

A review of gigaxonin mutations in giant axonal neuropathy (GAN) and cancer.
Kang JJ, Liu IY, Wang MB, Srivatsan ES
Human genetics135(7)675-84(2016 07)

Novel mutations in genes causing hereditary spastic paraplegia and Charcot-Marie-Tooth neuropathy identified by an optimized protocol for homozygosity mapping based on whole-exome sequencing.
Kancheva D, Atkinson D, De Rijk P, Zimon M, Chamova T, Mitev V, Yaramis A, Maria Fabrizi G, Topaloglu H, Tournev I, Parman Y, Parma Y, Battaloglu E, Estrada-Cuzcano A, Jordanova A
Genetics in medicine : official journal of the American College of Medical Genetics18(6)600-7(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GAN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GAN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu86294	XM_017023734.1 Latest version!	Homo sapiens gigaxonin (GAN), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu18520	NM_022041.3 Latest version!	Homo sapiens gigaxonin (GAN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GAN ( XM_017023734.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016879223.1 Homo sapiens gigaxonin (GAN), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu86294
Clone ID Related Accession (Same CDS sequence)	XM_017023734.1
Accession Version	XM_017023734.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	gigaxonin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGATG TTATGTCAGC TCTGTGGGTT TCAGGGTTGG ACTCCAGTTA TTTACGGGAA 
CAGATGCTGA ATGAACCATT AGTACGAGAA ATTGTCAAAG AGTGTAGCAA TATACCGCTC 
AGCCAGCCGC AGCAAGGGGA GGCGATGCTG GCCAACTTCA AACCCCGGGG CTACTCTGAG 
TGCATCGTGA CTGTTGGTGG AGAAGAGAGA GTTTCACGGA AACCCACAGC AGCGATGCGA 
TGCATGTGCC CTCTCTATGA CCCTAACAGG CAGCTTTGGA TCGAACTGGC CCCTTTAAGC 
ATGCCGAGAA TTAACCATGG AGTTCTCTCA GCAGAAGGAT TTTTGTTTGT ATTCGGGGGC 
CAAGATGAAA ATAAGCAGAC TCTTAGCTCA GGAGAAAAGT ATGATCCAGA TGCAAATACA 
TGGACAGCAT TGCCACCTAT GAACGAGGCA AGACATAACT TCGGAATTGT GGAGATAGAT 
GGGATGCTGT ACATTTTGGG AGGAGAGGAT GGTGAAAAGG AGCTGATTTC CATGGAGTGT 
TACGATATTT ATTCTAAAAC CTGGACAAAG CAACCTGATT TGACCATGGT CAGAAAGATC 
GGCTGCTATG CAGCTATGAA AAAGAAAATC TACGCCATGG GTGGAGGCTC CTACGGAAAG 
CTTTTTGAGT CTGTAGAGTG TTATGATCCC AGGACCCAGC AGTGGACTGC CATATGTCCA 
CTAAAAGAGA GGAGGTTTGG AGCGGTGGCC TGTGGAGTTG CTATGGAGCT GTATGTGTTT 
GGGGGAGTCC GAAGTCGTGA GGACGCCCAG GGTAGCGAGA TGGTAACTTG CAAGTCCGAG 
TTCTACCATG ATGAGTTTAA AAGGTGGATC TATCTTAACG ACCAGAATTT ATGCATCCCC 
GCCAGTTCCT CTTTTGTTTA TGGAGCTGTA CCTATAGGAG CCAGTATTTA TGTTATTGGA 
GATCTTGATA CAGGTACCAA TTACGACTAC GTGCGTGAGT TTAAAAGAAG CACAGGAACC 
TGGCACCACA CTAAACCACT CCTTCCATCC GACCTTCGCC GTACAGGATG TGCAGCCTTA 
CGCATTGCGA ATTGCAAGCT TTTCCGCCTG CAGCTTCAGC AAGGCTTATT CCGTATTCGT 
GTTCATTCCC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016879223.1
CDS	698..1852
Translation	MKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP

Target ORF information:

RefSeq Version	XM_017023734.1
Organism	Homo sapiens(human)
Definition	Homo sapiens gigaxonin (GAN), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017023734.1

ORF Insert Sequence:

ATGAAGGATG TTATGTCAGC TCTGTGGGTT TCAGGGTTGG ACTCCAGTTA TTTACGGGAA 
CAGATGCTGA ATGAACCATT AGTACGAGAA ATTGTCAAAG AGTGTAGCAA TATACCGCTC 
AGCCAGCCGC AGCAAGGGGA GGCGATGCTG GCCAACTTCA AACCCCGGGG CTACTCTGAG 
TGCATCGTGA CTGTTGGTGG AGAAGAGAGA GTTTCACGGA AACCCACAGC AGCGATGCGA 
TGCATGTGCC CTCTCTATGA CCCTAACAGG CAGCTTTGGA TCGAACTGGC CCCTTTAAGC 
ATGCCGAGAA TTAACCATGG AGTTCTCTCA GCAGAAGGAT TTTTGTTTGT ATTCGGGGGC 
CAAGATGAAA ATAAGCAGAC TCTTAGCTCA GGAGAAAAGT ATGATCCAGA TGCAAATACA 
TGGACAGCAT TGCCACCTAT GAACGAGGCA AGACATAACT TCGGAATTGT GGAGATAGAT 
GGGATGCTGT ACATTTTGGG AGGAGAGGAT GGTGAAAAGG AGCTGATTTC CATGGAGTGT 
TACGATATTT ATTCTAAAAC CTGGACAAAG CAACCTGATT TGACCATGGT CAGAAAGATC 
GGCTGCTATG CAGCTATGAA AAAGAAAATC TACGCCATGG GTGGAGGCTC CTACGGAAAG 
CTTTTTGAGT CTGTAGAGTG TTATGATCCC AGGACCCAGC AGTGGACTGC CATATGTCCA 
CTAAAAGAGA GGAGGTTTGG AGCGGTGGCC TGTGGAGTTG CTATGGAGCT GTATGTGTTT 
GGGGGAGTCC GAAGTCGTGA GGACGCCCAG GGTAGCGAGA TGGTAACTTG CAAGTCCGAG 
TTCTACCATG ATGAGTTTAA AAGGTGGATC TATCTTAACG ACCAGAATTT ATGCATCCCC 
GCCAGTTCCT CTTTTGTTTA TGGAGCTGTA CCTATAGGAG CCAGTATTTA TGTTATTGGA 
GATCTTGATA CAGGTACCAA TTACGACTAC GTGCGTGAGT TTAAAAGAAG CACAGGAACC 
TGGCACCACA CTAAACCACT CCTTCCATCC GACCTTCGCC GTACAGGATG TGCAGCCTTA 
CGCATTGCGA ATTGCAAGCT TTTCCGCCTG CAGCTTCAGC AAGGCTTATT CCGTATTCGT 
GTTCATTCCC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GAN ( NM_022041.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071324.1 Homo sapiens gigaxonin (GAN), mRNA.

Price & Availability↑

CloneID	OHu18520
Clone ID Related Accession (Same CDS sequence)	NM_022041.3
Accession Version	NM_022041.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Homo sapiens(human)
Product	gigaxonin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK095378.1, BC044840.1 and AC092139.5. This sequence is a reference standard in the RefSeqGene project. On Oct 25, 2008 this sequence version replaced NM_022041.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC044840.1, AF291673.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGG GCAGTGCCGT GTCTGACCCT CAGCACGCCG CGCGTCTGCT GCGAGCGCTC 
AGCTCTTTCC GCGAGGAGTC TCGCTTCTGC GACGCGCACC TGGTCCTCGA CGGGGAGGAG 
ATCCCGGTGC AGAAGAACAT CCTGGCGGCG GCCAGCCCGT ACATCAGGAC AAAGTTAAAC 
TATAATCCTC CAAAAGATGA TGGATCAACT TATAAGATTG AACTTGAAGG GATATCGGTA 
ATGGTTATGA GAGAGATCCT GGATTACATC TTCAGTGGGC AGATCAGGCT AAATGAAGAT 
ACAATCCAAG ATGTTGTTCA GGCAGCTGAC CTGCTGCTAC TGACGGACCT TAAAACCCTG 
TGCTGTGAGT TTTTGGAAGG CTGCATTGCT GCTGAGAACT GTATTGGTAT CCGTGACTTT 
GCACTACATT ACTGCCTCCA TCACGTTCAT TACCTTGCCA CAGAATACCT GGAGACTCAT 
TTCCGAGACG TCAGCAGCAC GGAAGAATTC TTAGAGCTGA GTCCTCAAAA GCTTAAAGAA 
GTGATTTCTC TTGAGAAGTT AAACGTTGGC AATGAAAGAT ATGTCTTTGA AGCAGTAATT 
CGATGGATAG CACATGATAC AGAAATAAGA AAGGTCCACA TGAAGGATGT TATGTCAGCT 
CTGTGGGTTT CAGGGTTGGA CTCCAGTTAT TTACGGGAAC AGATGCTGAA TGAACCATTA 
GTACGAGAAA TTGTCAAAGA GTGTAGCAAT ATACCGCTCA GCCAGCCGCA GCAAGGGGAG 
GCGATGCTGG CCAACTTCAA ACCCCGGGGC TACTCTGAGT GCATCGTGAC TGTTGGTGGA 
GAAGAGAGAG TTTCACGGAA ACCCACAGCA GCGATGCGAT GCATGTGCCC TCTCTATGAC 
CCTAACAGGC AGCTTTGGAT CGAACTGGCC CCTTTAAGCA TGCCGAGAAT TAACCATGGA 
GTTCTCTCAG CAGAAGGATT TTTGTTTGTA TTCGGGGGCC AAGATGAAAA TAAGCAGACT 
CTTAGCTCAG GAGAAAAGTA TGATCCAGAT GCAAATACAT GGACAGCATT GCCACCTATG 
AACGAGGCAA GACATAACTT CGGAATTGTG GAGATAGATG GGATGCTGTA CATTTTGGGA 
GGAGAGGATG GTGAAAAGGA GCTGATTTCC ATGGAGTGTT ACGATATTTA TTCTAAAACC 
TGGACAAAGC AACCTGATTT GACCATGGTC AGAAAGATCG GCTGCTATGC AGCTATGAAA 
AAGAAAATCT ACGCCATGGG TGGAGGCTCC TACGGAAAGC TTTTTGAGTC TGTAGAGTGT 
TATGATCCCA GGACCCAGCA GTGGACTGCC ATATGTCCAC TAAAAGAGAG GAGGTTTGGA 
GCGGTGGCCT GTGGAGTTGC TATGGAGCTG TATGTGTTTG GGGGAGTCCG AAGTCGTGAG 
GACGCCCAGG GTAGCGAGAT GGTAACTTGC AAGTCCGAGT TCTACCATGA TGAGTTTAAA 
AGGTGGATCT ATCTTAACGA CCAGAATTTA TGCATCCCCG CCAGTTCCTC TTTTGTTTAT 
GGAGCTGTAC CTATAGGAGC CAGTATTTAT GTTATTGGAG ATCTTGATAC AGGTACCAAT 
TACGACTACG TGCGTGAGTT TAAAAGAAGC ACAGGAACCT GGCACCACAC TAAACCACTC 
CTTCCATCCG ACCTTCGCCG TACAGGATGT GCAGCCTTAC GCATTGCGAA TTGCAAGCTT 
TTCCGCCTGC AGCTTCAGCA AGGCTTATTC CGTATTCGTG TTCATTCCCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071324.1
CDS	149..1942
Translation	MAEGSAVSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP

Target ORF information:

RefSeq Version	NM_022041.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gigaxonin (GAN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022041.3

ORF Insert Sequence:

ATGGCTGAGG GCAGTGCCGT GTCTGACCCT CAGCACGCCG CGCGTCTGCT GCGAGCGCTC 
AGCTCTTTCC GCGAGGAGTC TCGCTTCTGC GACGCGCACC TGGTCCTCGA CGGGGAGGAG 
ATCCCGGTGC AGAAGAACAT CCTGGCGGCG GCCAGCCCGT ACATCAGGAC AAAGTTAAAC 
TATAATCCTC CAAAAGATGA TGGATCAACT TATAAGATTG AACTTGAAGG GATATCGGTA 
ATGGTTATGA GAGAGATCCT GGATTACATC TTCAGTGGGC AGATCAGGCT AAATGAAGAT 
ACAATCCAAG ATGTTGTTCA GGCAGCTGAC CTGCTGCTAC TGACGGACCT TAAAACCCTG 
TGCTGTGAGT TTTTGGAAGG CTGCATTGCT GCTGAGAACT GTATTGGTAT CCGTGACTTT 
GCACTACATT ACTGCCTCCA TCACGTTCAT TACCTTGCCA CAGAATACCT GGAGACTCAT 
TTCCGAGACG TCAGCAGCAC GGAAGAATTC TTAGAGCTGA GTCCTCAAAA GCTTAAAGAA 
GTGATTTCTC TTGAGAAGTT AAACGTTGGC AATGAAAGAT ATGTCTTTGA AGCAGTAATT 
CGATGGATAG CACATGATAC AGAAATAAGA AAGGTCCACA TGAAGGATGT TATGTCAGCT 
CTGTGGGTTT CAGGGTTGGA CTCCAGTTAT TTACGGGAAC AGATGCTGAA TGAACCATTA 
GTACGAGAAA TTGTCAAAGA GTGTAGCAAT ATACCGCTCA GCCAGCCGCA GCAAGGGGAG 
GCGATGCTGG CCAACTTCAA ACCCCGGGGC TACTCTGAGT GCATCGTGAC TGTTGGTGGA 
GAAGAGAGAG TTTCACGGAA ACCCACAGCA GCGATGCGAT GCATGTGCCC TCTCTATGAC 
CCTAACAGGC AGCTTTGGAT CGAACTGGCC CCTTTAAGCA TGCCGAGAAT TAACCATGGA 
GTTCTCTCAG CAGAAGGATT TTTGTTTGTA TTCGGGGGCC AAGATGAAAA TAAGCAGACT 
CTTAGCTCAG GAGAAAAGTA TGATCCAGAT GCAAATACAT GGACAGCATT GCCACCTATG 
AACGAGGCAA GACATAACTT CGGAATTGTG GAGATAGATG GGATGCTGTA CATTTTGGGA 
GGAGAGGATG GTGAAAAGGA GCTGATTTCC ATGGAGTGTT ACGATATTTA TTCTAAAACC 
TGGACAAAGC AACCTGATTT GACCATGGTC AGAAAGATCG GCTGCTATGC AGCTATGAAA 
AAGAAAATCT ACGCCATGGG TGGAGGCTCC TACGGAAAGC TTTTTGAGTC TGTAGAGTGT 
TATGATCCCA GGACCCAGCA GTGGACTGCC ATATGTCCAC TAAAAGAGAG GAGGTTTGGA 
GCGGTGGCCT GTGGAGTTGC TATGGAGCTG TATGTGTTTG GGGGAGTCCG AAGTCGTGAG 
GACGCCCAGG GTAGCGAGAT GGTAACTTGC AAGTCCGAGT TCTACCATGA TGAGTTTAAA 
AGGTGGATCT ATCTTAACGA CCAGAATTTA TGCATCCCCG CCAGTTCCTC TTTTGTTTAT 
GGAGCTGTAC CTATAGGAGC CAGTATTTAT GTTATTGGAG ATCTTGATAC AGGTACCAAT 
TACGACTACG TGCGTGAGTT TAAAAGAAGC ACAGGAACCT GGCACCACAC TAAACCACTC 
CTTCCATCCG ACCTTCGCCG TACAGGATGT GCAGCCTTAC GCATTGCGAA TTGCAAGCTT 
TTCCGCCTGC AGCTTCAGCA AGGCTTATTC CGTATTCGTG TTCATTCCCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

KLHL16 Degrades Epidermal Keratins.
The Journal of investigative dermatology138(8)1871-1873(2018 08)
Büchau F,Munz C,Has C,Lehmann R,Magin TM

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Novel homozygous missense mutation in GAN associated with Charcot-Marie-Tooth disease type 2 in a large consanguineous family from Israel.
BMC medical genetics17(1)82(2016 Nov)
Aharoni S,Barwick KE,Straussberg R,Harlalka GV,Nevo Y,Chioza BA,McEntagart MM,Mimouni-Bloch A,Weedon M,Crosby AH

A review of gigaxonin mutations in giant axonal neuropathy (GAN) and cancer.
Human genetics135(7)675-84(2016 07)
Kang JJ,Liu IY,Wang MB,Srivatsan ES

Novel mutations in genes causing hereditary spastic paraplegia and Charcot-Marie-Tooth neuropathy identified by an optimized protocol for homozygosity mapping based on whole-exome sequencing.
Genetics in medicine : official journal of the American College of Medical Genetics18(6)600-7(2016 06)
Kancheva D,Atkinson D,De Rijk P,Zimon M,Chamova T,Mitev V,Yaramis A,Maria Fabrizi G,Topaloglu H,Tournev I,Parman Y,Parma Y,Battaloglu E,Estrada-Cuzcano A,Jordanova A

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GAN cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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