TYROBP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TYROBP
Entrez Gene ID	7305
Full Name	TYRO protein tyrosine kinase binding protein
Synonyms	DAP12,KARAP,PLOSL
General protein information	Preferred Names TYRO protein tyrosine kinase binding protein Names TYRO protein tyrosine kinase-binding protein DNAX-activation protein 12 KAR-associated protein killer-activating receptor-associated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.12
Summary	This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010].
Disorder MIM:	604142
Disorder Html:	Nasu-Hakola disease, 221770 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001173514.2	NP_001166985.1	TYRO protein tyrosine kinase-binding protein isoform 3 precursor
NM_001173515.2	NP_001166986.1	TYRO protein tyrosine kinase-binding protein isoform 4 precursor
NM_003332.3	NP_003323.1	TYRO protein tyrosine kinase-binding protein isoform 1 precursor
NM_001173514.1	NP_001166985.1	TYRO protein tyrosine kinase-binding protein isoform 3 precursor
NM_198125.3	NP_937758.1	TYRO protein tyrosine kinase-binding protein isoform 2 precursor
NM_003332.4	NP_003323.1	TYRO protein tyrosine kinase-binding protein isoform 1 precursor
NM_198125.2	NP_937758.1	TYRO protein tyrosine kinase-binding protein isoform 2 precursor
NM_001173515.1	NP_001166986.1	TYRO protein tyrosine kinase-binding protein isoform 4 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TYROBP	NP_003323.1
Macaca mulatta (Rhesus monkey)	TYROBP	NP_001028039.1
Canis lupus familiaris (dog)	TYROBP	NP_001184046.1
Bos taurus (cattle)	TYROBP	NP_777052.1
Mus musculus (house mouse)	Tyrobp	NP_035792.1
Pan troglodytes (chimpanzee)	TYROBP	NP_001077092.1
Rattus norvegicus (Norway rat)	Tyrobp	NP_997690.1

Gene Ontology
Bibliography

Related articles in PubMed

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.
Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME
Molecular psychiatry24(3)431-446(2019 03)

Heterozygous TYROBP deletion (PLOSL
Kaivola K, Jansson L, Saarentaus E, Kiviharju A, Rantalainen V, Eriksson JG, Strandberg TE, Polvikoski T, Myllykangas L, Tienari PJ
Neurobiology of aging64159.e1-159.e4(2018 04)

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, Xu H
Neuron97(5)1023-1031.e7(2018 03)

Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.
Biagioli M, Mencarelli A, Carino A, Cipriani S, Marchianò S, Fiorucci C, Donini A, Graziosi L, Baldelli F, Distrutti E, Costantino G, Fiorucci S
Inflammatory bowel diseases24(1)123-135(2017 12)

Mutations in TYROBP are not a common cause of dementia in a Turkish cohort.
Darwent L, Carmona S, Lohmann E, Guven G, Kun-Rodrigues C, Bilgic B, Hanagasi H, Gurvit H, Erginel-Unaltuna N, Pak M, Hardy J, Singleton A, Brás J, Guerreiro R
Neurobiology of aging58240.e1-240.e3(2017 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TYROBP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TYROBP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18008	NM_003332.4 Latest version!	Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16735	NM_001173514.2 Latest version!	Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu16898	NM_001173515.2 Latest version!	Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu16759	NM_198125.3 Latest version!	Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu16735	NM_001173514.1	Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu18008	NM_003332.3	Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16759	NM_198125.2	Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu16898	NM_001173515.1	Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TYROBP ( NM_003332.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003323.1 Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18008
Clone ID Related Accession (Same CDS sequence)	NM_003332.3 , NM_003332.4
Accession Version	NM_003332.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1556812800000
Organism	Homo sapiens(human)
Product	TYRO protein tyrosine kinase-binding protein isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP302545.1, AF019562.1 and BQ576278.1. This sequence is a reference standard in the RefSeqGene project. On Mar 13, 2010 this sequence version replaced NM_003332.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP302545.1, BP294784.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155770, SAMN01820695 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GGTCTCCGTC CTGTCCAGGC CCAGGCCCAG AGCGATTGCA GTTGCTCTAC GGTGAGCCCG 
GGCGTGCTGG CAGGGATCGT GATGGGAGAC CTGGTGCTGA CAGTGCTCAT TGCCCTGGCC 
GTGTACTTCC TGGGCCGGCT GGTCCCTCGG GGGCGAGGGG CTGCGGAGGC AGCGACCCGG 
AAACAGCGTA TCACTGAGAC CGAGTCGCCT TATCAGGAGC TCCAGGGTCA GAGGTCGGAT 
GTCTACAGCG ACCTCAACAC ACAGAGGCCG TATTACAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003323.1
CDS	82..423
Translation	MGGLEPCSRLLLLPLLLAVSGLRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

Target ORF information:

RefSeq Version	NM_003332.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003332.3

ORF Insert Sequence:

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GGTCTCCGTC CTGTCCAGGC CCAGGCCCAG AGCGATTGCA GTTGCTCTAC GGTGAGCCCG 
GGCGTGCTGG CAGGGATCGT GATGGGAGAC CTGGTGCTGA CAGTGCTCAT TGCCCTGGCC 
GTGTACTTCC TGGGCCGGCT GGTCCCTCGG GGGCGAGGGG CTGCGGAGGC AGCGACCCGG 
AAACAGCGTA TCACTGAGAC CGAGTCGCCT TATCAGGAGC TCCAGGGTCA GAGGTCGGAT 
GTCTACAGCG ACCTCAACAC ACAGAGGCCG TATTACAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TYROBP ( NM_003332.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003323.1 Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18008
Clone ID Related Accession (Same CDS sequence)	NM_003332.3 , NM_003332.4
Accession Version	NM_003332.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Homo sapiens(human)
Product	TYRO protein tyrosine kinase-binding protein isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP302545.1 and AF019562.1. On Aug 31, 2019 this sequence version replaced NM_003332.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB157293.1, BP295893.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GGTCTCCGTC CTGTCCAGGC CCAGGCCCAG AGCGATTGCA GTTGCTCTAC GGTGAGCCCG 
GGCGTGCTGG CAGGGATCGT GATGGGAGAC CTGGTGCTGA CAGTGCTCAT TGCCCTGGCC 
GTGTACTTCC TGGGCCGGCT GGTCCCTCGG GGGCGAGGGG CTGCGGAGGC AGCGACCCGG 
AAACAGCGTA TCACTGAGAC CGAGTCGCCT TATCAGGAGC TCCAGGGTCA GAGGTCGGAT 
GTCTACAGCG ACCTCAACAC ACAGAGGCCG TATTACAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003323.1
CDS	68..409
Translation	MGGLEPCSRLLLLPLLLAVSGLRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

Target ORF information:

RefSeq Version	NM_003332.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003332.4

ORF Insert Sequence:

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GGTCTCCGTC CTGTCCAGGC CCAGGCCCAG AGCGATTGCA GTTGCTCTAC GGTGAGCCCG 
GGCGTGCTGG CAGGGATCGT GATGGGAGAC CTGGTGCTGA CAGTGCTCAT TGCCCTGGCC 
GTGTACTTCC TGGGCCGGCT GGTCCCTCGG GGGCGAGGGG CTGCGGAGGC AGCGACCCGG 
AAACAGCGTA TCACTGAGAC CGAGTCGCCT TATCAGGAGC TCCAGGGTCA GAGGTCGGAT 
GTCTACAGCG ACCTCAACAC ACAGAGGCCG TATTACAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TYROBP ( NM_001173514.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166985.1 Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16735
Clone ID Related Accession (Same CDS sequence)	NM_001173514.2 , NM_001173514.1
Accession Version	NM_001173514.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Homo sapiens(human)
Product	TYRO protein tyrosine kinase-binding protein isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP302545.1, BP295666.1 and BQ576278.1. On Jun 2, 2019 this sequence version replaced NM_001173514.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP295666.1, DRR138524.1169443.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820689 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GATTGCAGTT GCTCTACGGT GAGCCCGGGC GTGCTGGCAG GGATCGTGAT GGGAGACCTG 
GTGCTGACAG TGCTCATTGC CCTGGCCGTG TACTTCCTGG GCCGGCTGGT CCCTCGGGGG 
CGAGGGGCTG CGGAGGCAGC GACCCGGAAA CAGCGTATCA CTGAGACCGA GTCGCCTTAT 
CAGGAGCTCC AGGGTCAGAG GTCGGATGTC TACAGCGACC TCAACACACA GAGGCCGTAT 
TACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166985.1
CDS	68..376
Translation	MGGLEPCSRLLLLPLLLAVSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

Target ORF information:

RefSeq Version	NM_001173514.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173514.2

ORF Insert Sequence:

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GATTGCAGTT GCTCTACGGT GAGCCCGGGC GTGCTGGCAG GGATCGTGAT GGGAGACCTG 
GTGCTGACAG TGCTCATTGC CCTGGCCGTG TACTTCCTGG GCCGGCTGGT CCCTCGGGGG 
CGAGGGGCTG CGGAGGCAGC GACCCGGAAA CAGCGTATCA CTGAGACCGA GTCGCCTTAT 
CAGGAGCTCC AGGGTCAGAG GTCGGATGTC TACAGCGACC TCAACACACA GAGGCCGTAT 
TACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TYROBP ( NM_001173514.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166985.1 Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16735
Clone ID Related Accession (Same CDS sequence)	NM_001173514.2 , NM_001173514.1
Accession Version	NM_001173514.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550851200000
Organism	Homo sapiens(human)
Product	TYRO protein tyrosine kinase-binding protein isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP302545.1, BP295666.1 and BQ576278.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP295666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820689 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GATTGCAGTT GCTCTACGGT GAGCCCGGGC GTGCTGGCAG GGATCGTGAT GGGAGACCTG 
GTGCTGACAG TGCTCATTGC CCTGGCCGTG TACTTCCTGG GCCGGCTGGT CCCTCGGGGG 
CGAGGGGCTG CGGAGGCAGC GACCCGGAAA CAGCGTATCA CTGAGACCGA GTCGCCTTAT 
CAGGAGCTCC AGGGTCAGAG GTCGGATGTC TACAGCGACC TCAACACACA GAGGCCGTAT 
TACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166985.1
CDS	82..390
Translation	MGGLEPCSRLLLLPLLLAVSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

Target ORF information:

RefSeq Version	NM_001173514.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173514.1

ORF Insert Sequence:

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GATTGCAGTT GCTCTACGGT GAGCCCGGGC GTGCTGGCAG GGATCGTGAT GGGAGACCTG 
GTGCTGACAG TGCTCATTGC CCTGGCCGTG TACTTCCTGG GCCGGCTGGT CCCTCGGGGG 
CGAGGGGCTG CGGAGGCAGC GACCCGGAAA CAGCGTATCA CTGAGACCGA GTCGCCTTAT 
CAGGAGCTCC AGGGTCAGAG GTCGGATGTC TACAGCGACC TCAACACACA GAGGCCGTAT 
TACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TYROBP ( NM_001173515.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166986.1 Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu16898
Clone ID Related Accession (Same CDS sequence)	NM_001173515.2 , NM_001173515.1
Accession Version	NM_001173515.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Homo sapiens(human)
Product	TYRO protein tyrosine kinase-binding protein isoform 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP305672.1. On Jun 2, 2019 this sequence version replaced NM_001173515.1. Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP305672.1, DRR138517.1062398.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820689 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GATTGCAGTT GCTCTACGGT GAGCCCGGGC GTGCTGGCAG GGATCGTGAT GGGAGACCTG 
GTGCTGACAG TGCTCATTGC CCTGGCCGTG TACTTCCTGG GCCGGCTGGT CCCTCGGGGG 
CGAGGGGCTG CGGAGGCGAC CCGGAAACAG CGTATCACTG AGACCGAGTC GCCTTATCAG 
GAGCTCCAGG GTCAGAGGTC GGATGTCTAC AGCGACCTCA ACACACAGAG GCCGTATTAC 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166986.1
CDS	68..373
Translation	MGGLEPCSRLLLLPLLLAVSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

Target ORF information:

RefSeq Version	NM_001173515.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173515.2

ORF Insert Sequence:

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GATTGCAGTT GCTCTACGGT GAGCCCGGGC GTGCTGGCAG GGATCGTGAT GGGAGACCTG 
GTGCTGACAG TGCTCATTGC CCTGGCCGTG TACTTCCTGG GCCGGCTGGT CCCTCGGGGG 
CGAGGGGCTG CGGAGGCGAC CCGGAAACAG CGTATCACTG AGACCGAGTC GCCTTATCAG 
GAGCTCCAGG GTCAGAGGTC GGATGTCTAC AGCGACCTCA ACACACAGAG GCCGTATTAC 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TYROBP ( NM_001173515.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166986.1 Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu16898
Clone ID Related Accession (Same CDS sequence)	NM_001173515.2 , NM_001173515.1
Accession Version	NM_001173515.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550851200000
Organism	Homo sapiens(human)
Product	TYRO protein tyrosine kinase-binding protein isoform 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP302545.1, BP305672.1 and BQ576278.1. Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP305672.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820689 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GATTGCAGTT GCTCTACGGT GAGCCCGGGC GTGCTGGCAG GGATCGTGAT GGGAGACCTG 
GTGCTGACAG TGCTCATTGC CCTGGCCGTG TACTTCCTGG GCCGGCTGGT CCCTCGGGGG 
CGAGGGGCTG CGGAGGCGAC CCGGAAACAG CGTATCACTG AGACCGAGTC GCCTTATCAG 
GAGCTCCAGG GTCAGAGGTC GGATGTCTAC AGCGACCTCA ACACACAGAG GCCGTATTAC 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166986.1
CDS	82..387
Translation	MGGLEPCSRLLLLPLLLAVSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

Target ORF information:

RefSeq Version	NM_001173515.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173515.1

ORF Insert Sequence:

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GATTGCAGTT GCTCTACGGT GAGCCCGGGC GTGCTGGCAG GGATCGTGAT GGGAGACCTG 
GTGCTGACAG TGCTCATTGC CCTGGCCGTG TACTTCCTGG GCCGGCTGGT CCCTCGGGGG 
CGAGGGGCTG CGGAGGCGAC CCGGAAACAG CGTATCACTG AGACCGAGTC GCCTTATCAG 
GAGCTCCAGG GTCAGAGGTC GGATGTCTAC AGCGACCTCA ACACACAGAG GCCGTATTAC 
AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TYROBP ( NM_198125.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_937758.1 Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16759
Clone ID Related Accession (Same CDS sequence)	NM_198125.3 , NM_198125.2
Accession Version	NM_198125.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Homo sapiens(human)
Product	TYRO protein tyrosine kinase-binding protein isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK290385.1 and BQ576278.1. On Jun 3, 2019 this sequence version replaced NM_198125.2. Transcript Variant: This variant (2), also known as 112DAP12, uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) is 1 aa shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA462975.1, AK290385.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GGTCTCCGTC CTGTCCAGGC CCAGGCCCAG AGCGATTGCA GTTGCTCTAC GGTGAGCCCG 
GGCGTGCTGG CAGGGATCGT GATGGGAGAC CTGGTGCTGA CAGTGCTCAT TGCCCTGGCC 
GTGTACTTCC TGGGCCGGCT GGTCCCTCGG GGGCGAGGGG CTGCGGAGGC GACCCGGAAA 
CAGCGTATCA CTGAGACCGA GTCGCCTTAT CAGGAGCTCC AGGGTCAGAG GTCGGATGTC 
TACAGCGACC TCAACACACA GAGGCCGTAT TACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937758.1
CDS	68..406
Translation	MGGLEPCSRLLLLPLLLAVSGLRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

Target ORF information:

RefSeq Version	NM_198125.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane immune signaling adaptor TYROBP (TYROBP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198125.3

ORF Insert Sequence:

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GGTCTCCGTC CTGTCCAGGC CCAGGCCCAG AGCGATTGCA GTTGCTCTAC GGTGAGCCCG 
GGCGTGCTGG CAGGGATCGT GATGGGAGAC CTGGTGCTGA CAGTGCTCAT TGCCCTGGCC 
GTGTACTTCC TGGGCCGGCT GGTCCCTCGG GGGCGAGGGG CTGCGGAGGC GACCCGGAAA 
CAGCGTATCA CTGAGACCGA GTCGCCTTAT CAGGAGCTCC AGGGTCAGAG GTCGGATGTC 
TACAGCGACC TCAACACACA GAGGCCGTAT TACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TYROBP ( NM_198125.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_937758.1 Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16759
Clone ID Related Accession (Same CDS sequence)	NM_198125.3 , NM_198125.2
Accession Version	NM_198125.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550851200000
Organism	Homo sapiens(human)
Product	TYRO protein tyrosine kinase-binding protein isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP302545.1, AK290385.1 and BQ576278.1. On Mar 13, 2010 this sequence version replaced NM_198125.1. Transcript Variant: This variant (2), also known as 112DAP12, uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) is 1 aa shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP197272.1, DA462975.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GGTCTCCGTC CTGTCCAGGC CCAGGCCCAG AGCGATTGCA GTTGCTCTAC GGTGAGCCCG 
GGCGTGCTGG CAGGGATCGT GATGGGAGAC CTGGTGCTGA CAGTGCTCAT TGCCCTGGCC 
GTGTACTTCC TGGGCCGGCT GGTCCCTCGG GGGCGAGGGG CTGCGGAGGC GACCCGGAAA 
CAGCGTATCA CTGAGACCGA GTCGCCTTAT CAGGAGCTCC AGGGTCAGAG GTCGGATGTC 
TACAGCGACC TCAACACACA GAGGCCGTAT TACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937758.1
CDS	82..420
Translation	MGGLEPCSRLLLLPLLLAVSGLRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

Target ORF information:

RefSeq Version	NM_198125.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198125.2

ORF Insert Sequence:

ATGGGGGGAC TTGAACCCTG CAGCAGGCTC CTGCTCCTGC CTCTCCTGCT GGCTGTAAGT 
GGTCTCCGTC CTGTCCAGGC CCAGGCCCAG AGCGATTGCA GTTGCTCTAC GGTGAGCCCG 
GGCGTGCTGG CAGGGATCGT GATGGGAGAC CTGGTGCTGA CAGTGCTCAT TGCCCTGGCC 
GTGTACTTCC TGGGCCGGCT GGTCCCTCGG GGGCGAGGGG CTGCGGAGGC GACCCGGAAA 
CAGCGTATCA CTGAGACCGA GTCGCCTTAT CAGGAGCTCC AGGGTCAGAG GTCGGATGTC 
TACAGCGACC TCAACACACA GAGGCCGTAT TACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.
Molecular psychiatry24(3)431-446(2019 03)
Haure-Mirande JV,Wang M,Audrain M,Fanutza T,Kim SH,Heja S,Readhead B,Dudley JT,Blitzer RD,Schadt EE,Zhang B,Gandy S,Ehrlich ME

Heterozygous TYROBP deletion (PLOSL
Neurobiology of aging64159.e1-159.e4(2018 04)
Kaivola K,Jansson L,Saarentaus E,Kiviharju A,Rantalainen V,Eriksson JG,Strandberg TE,Polvikoski T,Myllykangas L,Tienari PJ

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Neuron97(5)1023-1031.e7(2018 03)
Zhao Y,Wu X,Li X,Jiang LL,Gui X,Liu Y,Sun Y,Zhu B,Piña-Crespo JC,Zhang M,Zhang N,Chen X,Bu G,An Z,Huang TY,Xu H

Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.
Inflammatory bowel diseases24(1)123-135(2017 12)
Biagioli M,Mencarelli A,Carino A,Cipriani S,Marchianò S,Fiorucci C,Donini A,Graziosi L,Baldelli F,Distrutti E,Costantino G,Fiorucci S

Mutations in TYROBP are not a common cause of dementia in a Turkish cohort.
Neurobiology of aging58240.e1-240.e3(2017 10)
Darwent L,Carmona S,Lohmann E,Guven G,Kun-Rodrigues C,Bilgic B,Hanagasi H,Gurvit H,Erginel-Unaltuna N,Pak M,Hardy J,Singleton A,Brás J,Guerreiro R

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TYROBP cDNA ORF clone, Homo sapiens(human)

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