TUBB2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TUBB2A
Entrez Gene ID	7280
Full Name	tubulin beta 2A class IIa
Synonyms	CDCBM5,TUBB,TUBB2
General protein information	Preferred Names tubulin beta 2A class IIa Names tubulin beta-2A chain class IIa beta-tubulin tubulin, beta 2A tubulin, beta polypeptide 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p25.2
Summary	Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015].
Disorder MIM:	615101
Disorder Html:	Cortical dysplasia, complex, with other brain malformations 5, 615763 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001069.3	NP_001060.1	tubulin beta-2A chain isoform 1
NM_001310315.1	NP_001297244.1	tubulin beta-2A chain isoform 2
NM_001310315.2	NP_001297244.1	tubulin beta-2A chain isoform 2
NM_001069.2	NP_001060.1	tubulin beta-2A chain isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tubb2a	NP_033476.1
Rattus norvegicus (Norway rat)	Tubb2a	NP_001102589.1
Homo sapiens (human)	TUBB2A	NP_001060.1
Xenopus tropicalis (tropical clawed frog)	tubb4a	NP_001032345.1
Bos taurus (cattle)	LOC100295973	XP_002697652.1
Oryza sativa (rice)	Os06g0671900	NP_001058334.1
Pan troglodytes (chimpanzee)	TUBB2A	XP_518209.3
Danio rerio (zebrafish)	zgc:112335	NP_001019593.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005293	XP_309083.4
Drosophila melanogaster (fruit fly)	betaTub97EF	NP_001163753.1
Arabidopsis thaliana (thale cress)	TUB7	NP_180515.1

Gene Ontology
Bibliography

Related articles in PubMed

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
Lee JH, Han JH, Kim H, Park SM, Joe EH, Jou I
Acta neuropathologica communications7(1)68(2019 05)

Over-Expression of βII-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer.
Ruksha K, Mezheyeuski A, Nerovnya A, Bich T, Tur G, Gorgun J, Luduena R, Portyanko A
Cells8(1)(2019 01)

Defective kinesin binding of TUBB2A causes progressive spastic ataxia syndrome resembling sacsinopathy.
Sferra A, Fattori F, Rizza T, Flex E, Bellacchio E, Bruselles A, Petrini S, Cecchetti S, Teson M, Restaldi F, Ciolfi A, Santorelli FM, Zanni G, Barresi S, Castiglioni C, Tartaglia M, Bertini E
Human molecular genetics27(11)1892-1904(2018 06)

De novo pathogenic variant in TUBB2A presenting with arthrogryposis multiplex congenita, brain abnormalities, and severe developmental delay.
Ejaz R, Lionel AC, Blaser S, Walker S, Scherer SW, Babul-Hirji R, Marshall CR, Stavropoulos DJ, Chitayat D
American journal of medical genetics. Part A173(10)2725-2730(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TUBB2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TUBB2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu61178	NM_001310315.2 Latest version!	Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu17758	NM_001069.3 Latest version!	Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu61178	NM_001310315.1	Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu17758	NM_001069.2	Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TUBB2A ( NM_001310315.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001297244.1 Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu61178
Clone ID Related Accession (Same CDS sequence)	NM_001310315.1 , NM_001310315.2
Accession Version	NM_001310315.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550937600000
Organism	Homo sapiens(human)
Product	tubulin beta-2A chain isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP381259.1, BM846690.1 and BC018780.1. Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.167957.1, SRR1803615.207689.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCACTT TCCCTCTGGC AGGCCAGAGT GGAGCCGGGA ATAACTGGGC CAAGGGCCAC 
TACACAGAGG GAGCCGAGCT GGTCGACTCG GTCCTGGATG TGGTGAGGAA GGAGTCAGAG 
AGCTGTGACT GTCTCCAGGG CTTCCAGCTG ACCCACTCTC TGGGGGGCGG CACGGGGTCC 
GGGATGGGCA CCCTGCTCAT CAGCAAGATC CGGGAAGAGT ACCCAGACCG CATCATGAAC 
ACCTTCAGCG TCATGCCCTC ACCCAAGGTG TCAGACACGG TGGTGGAGCC CTACAACGCC 
ACCCTCTCTG TCCACCAGCT GGTGGAAAAC ACAGATGAAA CCTACTCCAT TGATAACGAG 
GCCCTGTATG ACATCTGCTT CCGCACCCTG AAGCTGACCA CCCCCACCTA CGGGGACCTC 
AACCACCTGG TGTCGGCCAC CATGAGCGGG GTCACCACCT GCCTGCGCTT CCCGGGCCAG 
CTGAACGCAG ACCTGCGCAA GCTGGCGGTG AACATGGTGC CCTTCCCTCG CCTGCACTTC 
TTCATGCCCG GCTTCGCGCC CCTGACCAGC CGGGGCAGCC AGCAGTACCG GGCGCTCACG 
GTGCCCGAGC TCACCCAGCA GATGTTCGAC TCCAAGAACA TGATGGCCGC CTGCGACCCG 
CGCCACGGCC GCTACCTGAC GGTGGCTGCC ATCTTCCGGG GCCGCATGTC CATGAAGGAG 
GTGGACGAGC AGATGCTCAA CGTGCAGAAC AAGAACAGCA GCTACTTCGT GGAGTGGATC 
CCCAACAACG TGAAGACGGC CGTGTGCGAC ATCCCGCCCC GCGGCCTGAA GATGTCGGCC 
ACCTTCATCG GCAACAGCAC GGCCATCCAG GAGCTGTTCA AGCGCATCTC CGAGCAGTTC 
ACGGCCATGT TCCGGCGCAA GGCCTTCCTG CACTGGTACA CGGGCGAGGG CATGGACGAG 
ATGGAGTTCA CCGAGGCCGA GAGCAACATG AACGACCTGG TGTCCGAGTA CCAGCAGTAC 
CAGGACGCCA CGGCCGACGA ACAAGGGGAG TTCGAGGAGG AGGAGGGCGA GGACGAGGCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001297244.1
CDS	474..1556
Translation	MFTFPLAGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA

Target ORF information:

RefSeq Version	NM_001310315.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310315.1

ORF Insert Sequence:

ATGTTCACTT TCCCTCTGGC AGGCCAGAGT GGAGCCGGGA ATAACTGGGC CAAGGGCCAC 
TACACAGAGG GAGCCGAGCT GGTCGACTCG GTCCTGGATG TGGTGAGGAA GGAGTCAGAG 
AGCTGTGACT GTCTCCAGGG CTTCCAGCTG ACCCACTCTC TGGGGGGCGG CACGGGGTCC 
GGGATGGGCA CCCTGCTCAT CAGCAAGATC CGGGAAGAGT ACCCAGACCG CATCATGAAC 
ACCTTCAGCG TCATGCCCTC ACCCAAGGTG TCAGACACGG TGGTGGAGCC CTACAACGCC 
ACCCTCTCTG TCCACCAGCT GGTGGAAAAC ACAGATGAAA CCTACTCCAT TGATAACGAG 
GCCCTGTATG ACATCTGCTT CCGCACCCTG AAGCTGACCA CCCCCACCTA CGGGGACCTC 
AACCACCTGG TGTCGGCCAC CATGAGCGGG GTCACCACCT GCCTGCGCTT CCCGGGCCAG 
CTGAACGCAG ACCTGCGCAA GCTGGCGGTG AACATGGTGC CCTTCCCTCG CCTGCACTTC 
TTCATGCCCG GCTTCGCGCC CCTGACCAGC CGGGGCAGCC AGCAGTACCG GGCGCTCACG 
GTGCCCGAGC TCACCCAGCA GATGTTCGAC TCCAAGAACA TGATGGCCGC CTGCGACCCG 
CGCCACGGCC GCTACCTGAC GGTGGCTGCC ATCTTCCGGG GCCGCATGTC CATGAAGGAG 
GTGGACGAGC AGATGCTCAA CGTGCAGAAC AAGAACAGCA GCTACTTCGT GGAGTGGATC 
CCCAACAACG TGAAGACGGC CGTGTGCGAC ATCCCGCCCC GCGGCCTGAA GATGTCGGCC 
ACCTTCATCG GCAACAGCAC GGCCATCCAG GAGCTGTTCA AGCGCATCTC CGAGCAGTTC 
ACGGCCATGT TCCGGCGCAA GGCCTTCCTG CACTGGTACA CGGGCGAGGG CATGGACGAG 
ATGGAGTTCA CCGAGGCCGA GAGCAACATG AACGACCTGG TGTCCGAGTA CCAGCAGTAC 
CAGGACGCCA CGGCCGACGA ACAAGGGGAG TTCGAGGAGG AGGAGGGCGA GGACGAGGCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TUBB2A ( NM_001310315.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001297244.1 Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu61178
Clone ID Related Accession (Same CDS sequence)	NM_001310315.1 , NM_001310315.2
Accession Version	NM_001310315.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576339200000
Organism	Homo sapiens(human)
Product	tubulin beta-2A chain isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP381259.1, BM846690.1 and BC018780.1. On Jun 1, 2019 this sequence version replaced NM_001310315.1. Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1153922.1, SRR7410570.256183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCACTT TCCCTCTGGC AGGCCAGAGT GGAGCCGGGA ATAACTGGGC CAAGGGCCAC 
TACACAGAGG GAGCCGAGCT GGTCGACTCG GTCCTGGATG TGGTGAGGAA GGAGTCAGAG 
AGCTGTGACT GTCTCCAGGG CTTCCAGCTG ACCCACTCTC TGGGGGGCGG CACGGGGTCC 
GGGATGGGCA CCCTGCTCAT CAGCAAGATC CGGGAAGAGT ACCCAGACCG CATCATGAAC 
ACCTTCAGCG TCATGCCCTC ACCCAAGGTG TCAGACACGG TGGTGGAGCC CTACAACGCC 
ACCCTCTCTG TCCACCAGCT GGTGGAAAAC ACAGATGAAA CCTACTCCAT TGATAACGAG 
GCCCTGTATG ACATCTGCTT CCGCACCCTG AAGCTGACCA CCCCCACCTA CGGGGACCTC 
AACCACCTGG TGTCGGCCAC CATGAGCGGG GTCACCACCT GCCTGCGCTT CCCGGGCCAG 
CTGAACGCAG ACCTGCGCAA GCTGGCGGTG AACATGGTGC CCTTCCCTCG CCTGCACTTC 
TTCATGCCCG GCTTCGCGCC CCTGACCAGC CGGGGCAGCC AGCAGTACCG GGCGCTCACG 
GTGCCCGAGC TCACCCAGCA GATGTTCGAC TCCAAGAACA TGATGGCCGC CTGCGACCCG 
CGCCACGGCC GCTACCTGAC GGTGGCTGCC ATCTTCCGGG GCCGCATGTC CATGAAGGAG 
GTGGACGAGC AGATGCTCAA CGTGCAGAAC AAGAACAGCA GCTACTTCGT GGAGTGGATC 
CCCAACAACG TGAAGACGGC CGTGTGCGAC ATCCCGCCCC GCGGCCTGAA GATGTCGGCC 
ACCTTCATCG GCAACAGCAC GGCCATCCAG GAGCTGTTCA AGCGCATCTC CGAGCAGTTC 
ACGGCCATGT TCCGGCGCAA GGCCTTCCTG CACTGGTACA CGGGCGAGGG CATGGACGAG 
ATGGAGTTCA CCGAGGCCGA GAGCAACATG AACGACCTGG TGTCCGAGTA CCAGCAGTAC 
CAGGACGCCA CGGCCGACGA ACAAGGGGAG TTCGAGGAGG AGGAGGGCGA GGACGAGGCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001297244.1
CDS	469..1551
Translation	MFTFPLAGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA

Target ORF information:

RefSeq Version	NM_001310315.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310315.2

ORF Insert Sequence:

ATGTTCACTT TCCCTCTGGC AGGCCAGAGT GGAGCCGGGA ATAACTGGGC CAAGGGCCAC 
TACACAGAGG GAGCCGAGCT GGTCGACTCG GTCCTGGATG TGGTGAGGAA GGAGTCAGAG 
AGCTGTGACT GTCTCCAGGG CTTCCAGCTG ACCCACTCTC TGGGGGGCGG CACGGGGTCC 
GGGATGGGCA CCCTGCTCAT CAGCAAGATC CGGGAAGAGT ACCCAGACCG CATCATGAAC 
ACCTTCAGCG TCATGCCCTC ACCCAAGGTG TCAGACACGG TGGTGGAGCC CTACAACGCC 
ACCCTCTCTG TCCACCAGCT GGTGGAAAAC ACAGATGAAA CCTACTCCAT TGATAACGAG 
GCCCTGTATG ACATCTGCTT CCGCACCCTG AAGCTGACCA CCCCCACCTA CGGGGACCTC 
AACCACCTGG TGTCGGCCAC CATGAGCGGG GTCACCACCT GCCTGCGCTT CCCGGGCCAG 
CTGAACGCAG ACCTGCGCAA GCTGGCGGTG AACATGGTGC CCTTCCCTCG CCTGCACTTC 
TTCATGCCCG GCTTCGCGCC CCTGACCAGC CGGGGCAGCC AGCAGTACCG GGCGCTCACG 
GTGCCCGAGC TCACCCAGCA GATGTTCGAC TCCAAGAACA TGATGGCCGC CTGCGACCCG 
CGCCACGGCC GCTACCTGAC GGTGGCTGCC ATCTTCCGGG GCCGCATGTC CATGAAGGAG 
GTGGACGAGC AGATGCTCAA CGTGCAGAAC AAGAACAGCA GCTACTTCGT GGAGTGGATC 
CCCAACAACG TGAAGACGGC CGTGTGCGAC ATCCCGCCCC GCGGCCTGAA GATGTCGGCC 
ACCTTCATCG GCAACAGCAC GGCCATCCAG GAGCTGTTCA AGCGCATCTC CGAGCAGTTC 
ACGGCCATGT TCCGGCGCAA GGCCTTCCTG CACTGGTACA CGGGCGAGGG CATGGACGAG 
ATGGAGTTCA CCGAGGCCGA GAGCAACATG AACGACCTGG TGTCCGAGTA CCAGCAGTAC 
CAGGACGCCA CGGCCGACGA ACAAGGGGAG TTCGAGGAGG AGGAGGGCGA GGACGAGGCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TUBB2A ( NM_001069.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001060.1 Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17758
Clone ID Related Accession (Same CDS sequence)	NM_001069.3 , NM_001069.2
Accession Version	NM_001069.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576339200000
Organism	Homo sapiens(human)
Product	tubulin beta-2A chain isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031963.40, X79535.1 and AL038778.2. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001069.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.53490.1, SRR3476690.1019106.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000333628.4/ ENSP00000369703.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGCGAGA TCGTGCACAT CCAGGCGGGC CAGTGCGGCA ACCAGATCGG CGCCAAGTTT 
TGGGAGGTCA TCAGCGATGA GCATGGGATC GACCCCACAG GCAGTTACCA TGGAGACAGT 
GACTTGCAGC TGGAGAGAAT CAACGTGTAC TACAATGAGG CTGCTGGTAA CAAATATGTA 
CCTCGGGCCA TCCTGGTGGA TCTGGAGCCT GGCACCATGG ACTCTGTCAG GTCTGGACCC 
TTCGGCCAGA TCTTCAGACC AGACAACTTC GTGTTCGGCC AGAGTGGAGC CGGGAATAAC 
TGGGCCAAGG GCCACTACAC AGAGGGAGCC GAGCTGGTCG ACTCGGTCCT GGATGTGGTG 
AGGAAGGAGT CAGAGAGCTG TGACTGTCTC CAGGGCTTCC AGCTGACCCA CTCTCTGGGG 
GGCGGCACGG GGTCCGGGAT GGGCACCCTG CTCATCAGCA AGATCCGGGA AGAGTACCCA 
GACCGCATCA TGAACACCTT CAGCGTCATG CCCTCACCCA AGGTGTCAGA CACGGTGGTG 
GAGCCCTACA ACGCCACCCT CTCTGTCCAC CAGCTGGTGG AAAACACAGA TGAAACCTAC 
TCCATTGATA ACGAGGCCCT GTATGACATC TGCTTCCGCA CCCTGAAGCT GACCACCCCC 
ACCTACGGGG ACCTCAACCA CCTGGTGTCG GCCACCATGA GCGGGGTCAC CACCTGCCTG 
CGCTTCCCGG GCCAGCTGAA CGCAGACCTG CGCAAGCTGG CGGTGAACAT GGTGCCCTTC 
CCTCGCCTGC ACTTCTTCAT GCCCGGCTTC GCGCCCCTGA CCAGCCGGGG CAGCCAGCAG 
TACCGGGCGC TCACGGTGCC CGAGCTCACC CAGCAGATGT TCGACTCCAA GAACATGATG 
GCCGCCTGCG ACCCGCGCCA CGGCCGCTAC CTGACGGTGG CTGCCATCTT CCGGGGCCGC 
ATGTCCATGA AGGAGGTGGA CGAGCAGATG CTCAACGTGC AGAACAAGAA CAGCAGCTAC 
TTCGTGGAGT GGATCCCCAA CAACGTGAAG ACGGCCGTGT GCGACATCCC GCCCCGCGGC 
CTGAAGATGT CGGCCACCTT CATCGGCAAC AGCACGGCCA TCCAGGAGCT GTTCAAGCGC 
ATCTCCGAGC AGTTCACGGC CATGTTCCGG CGCAAGGCCT TCCTGCACTG GTACACGGGC 
GAGGGCATGG ACGAGATGGA GTTCACCGAG GCCGAGAGCA ACATGAACGA CCTGGTGTCC 
GAGTACCAGC AGTACCAGGA CGCCACGGCC GACGAACAAG GGGAGTTCGA GGAGGAGGAG 
GGCGAGGACG AGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001060.1
CDS	82..1419
Translation	MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA

Target ORF information:

RefSeq Version	NM_001069.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001069.3

ORF Insert Sequence:

ATGCGCGAGA TCGTGCACAT CCAGGCGGGC CAGTGCGGCA ACCAGATCGG CGCCAAGTTT 
TGGGAGGTCA TCAGCGATGA GCATGGGATC GACCCCACAG GCAGTTACCA TGGAGACAGT 
GACTTGCAGC TGGAGAGAAT CAACGTGTAC TACAATGAGG CTGCTGGTAA CAAATATGTA 
CCTCGGGCCA TCCTGGTGGA TCTGGAGCCT GGCACCATGG ACTCTGTCAG GTCTGGACCC 
TTCGGCCAGA TCTTCAGACC AGACAACTTC GTGTTCGGCC AGAGTGGAGC CGGGAATAAC 
TGGGCCAAGG GCCACTACAC AGAGGGAGCC GAGCTGGTCG ACTCGGTCCT GGATGTGGTG 
AGGAAGGAGT CAGAGAGCTG TGACTGTCTC CAGGGCTTCC AGCTGACCCA CTCTCTGGGG 
GGCGGCACGG GGTCCGGGAT GGGCACCCTG CTCATCAGCA AGATCCGGGA AGAGTACCCA 
GACCGCATCA TGAACACCTT CAGCGTCATG CCCTCACCCA AGGTGTCAGA CACGGTGGTG 
GAGCCCTACA ACGCCACCCT CTCTGTCCAC CAGCTGGTGG AAAACACAGA TGAAACCTAC 
TCCATTGATA ACGAGGCCCT GTATGACATC TGCTTCCGCA CCCTGAAGCT GACCACCCCC 
ACCTACGGGG ACCTCAACCA CCTGGTGTCG GCCACCATGA GCGGGGTCAC CACCTGCCTG 
CGCTTCCCGG GCCAGCTGAA CGCAGACCTG CGCAAGCTGG CGGTGAACAT GGTGCCCTTC 
CCTCGCCTGC ACTTCTTCAT GCCCGGCTTC GCGCCCCTGA CCAGCCGGGG CAGCCAGCAG 
TACCGGGCGC TCACGGTGCC CGAGCTCACC CAGCAGATGT TCGACTCCAA GAACATGATG 
GCCGCCTGCG ACCCGCGCCA CGGCCGCTAC CTGACGGTGG CTGCCATCTT CCGGGGCCGC 
ATGTCCATGA AGGAGGTGGA CGAGCAGATG CTCAACGTGC AGAACAAGAA CAGCAGCTAC 
TTCGTGGAGT GGATCCCCAA CAACGTGAAG ACGGCCGTGT GCGACATCCC GCCCCGCGGC 
CTGAAGATGT CGGCCACCTT CATCGGCAAC AGCACGGCCA TCCAGGAGCT GTTCAAGCGC 
ATCTCCGAGC AGTTCACGGC CATGTTCCGG CGCAAGGCCT TCCTGCACTG GTACACGGGC 
GAGGGCATGG ACGAGATGGA GTTCACCGAG GCCGAGAGCA ACATGAACGA CCTGGTGTCC 
GAGTACCAGC AGTACCAGGA CGCCACGGCC GACGAACAAG GGGAGTTCGA GGAGGAGGAG 
GGCGAGGACG AGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TUBB2A ( NM_001069.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001060.1 Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 1, mRNA.

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CloneID	OHu17758
Clone ID Related Accession (Same CDS sequence)	NM_001069.3 , NM_001069.2
Accession Version	NM_001069.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Homo sapiens(human)
Product	tubulin beta-2A chain isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031963.40, X79535.1 and AL038778.2. This sequence is a reference standard in the RefSeqGene project. On Jun 29, 2005 this sequence version replaced NM_001069.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.172934.1, SRR1660805.176390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCGAGA TCGTGCACAT CCAGGCGGGC CAGTGCGGCA ACCAGATCGG CGCCAAGTTT 
TGGGAGGTCA TCAGCGATGA GCATGGGATC GACCCCACAG GCAGTTACCA TGGAGACAGT 
GACTTGCAGC TGGAGAGAAT CAACGTGTAC TACAATGAGG CTGCTGGTAA CAAATATGTA 
CCTCGGGCCA TCCTGGTGGA TCTGGAGCCT GGCACCATGG ACTCTGTCAG GTCTGGACCC 
TTCGGCCAGA TCTTCAGACC AGACAACTTC GTGTTCGGCC AGAGTGGAGC CGGGAATAAC 
TGGGCCAAGG GCCACTACAC AGAGGGAGCC GAGCTGGTCG ACTCGGTCCT GGATGTGGTG 
AGGAAGGAGT CAGAGAGCTG TGACTGTCTC CAGGGCTTCC AGCTGACCCA CTCTCTGGGG 
GGCGGCACGG GGTCCGGGAT GGGCACCCTG CTCATCAGCA AGATCCGGGA AGAGTACCCA 
GACCGCATCA TGAACACCTT CAGCGTCATG CCCTCACCCA AGGTGTCAGA CACGGTGGTG 
GAGCCCTACA ACGCCACCCT CTCTGTCCAC CAGCTGGTGG AAAACACAGA TGAAACCTAC 
TCCATTGATA ACGAGGCCCT GTATGACATC TGCTTCCGCA CCCTGAAGCT GACCACCCCC 
ACCTACGGGG ACCTCAACCA CCTGGTGTCG GCCACCATGA GCGGGGTCAC CACCTGCCTG 
CGCTTCCCGG GCCAGCTGAA CGCAGACCTG CGCAAGCTGG CGGTGAACAT GGTGCCCTTC 
CCTCGCCTGC ACTTCTTCAT GCCCGGCTTC GCGCCCCTGA CCAGCCGGGG CAGCCAGCAG 
TACCGGGCGC TCACGGTGCC CGAGCTCACC CAGCAGATGT TCGACTCCAA GAACATGATG 
GCCGCCTGCG ACCCGCGCCA CGGCCGCTAC CTGACGGTGG CTGCCATCTT CCGGGGCCGC 
ATGTCCATGA AGGAGGTGGA CGAGCAGATG CTCAACGTGC AGAACAAGAA CAGCAGCTAC 
TTCGTGGAGT GGATCCCCAA CAACGTGAAG ACGGCCGTGT GCGACATCCC GCCCCGCGGC 
CTGAAGATGT CGGCCACCTT CATCGGCAAC AGCACGGCCA TCCAGGAGCT GTTCAAGCGC 
ATCTCCGAGC AGTTCACGGC CATGTTCCGG CGCAAGGCCT TCCTGCACTG GTACACGGGC 
GAGGGCATGG ACGAGATGGA GTTCACCGAG GCCGAGAGCA ACATGAACGA CCTGGTGTCC 
GAGTACCAGC AGTACCAGGA CGCCACGGCC GACGAACAAG GGGAGTTCGA GGAGGAGGAG 
GGCGAGGACG AGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001060.1
CDS	87..1424
Translation	MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA

Target ORF information:

RefSeq Version	NM_001069.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin beta 2A class IIa (TUBB2A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001069.2

ORF Insert Sequence:

ATGCGCGAGA TCGTGCACAT CCAGGCGGGC CAGTGCGGCA ACCAGATCGG CGCCAAGTTT 
TGGGAGGTCA TCAGCGATGA GCATGGGATC GACCCCACAG GCAGTTACCA TGGAGACAGT 
GACTTGCAGC TGGAGAGAAT CAACGTGTAC TACAATGAGG CTGCTGGTAA CAAATATGTA 
CCTCGGGCCA TCCTGGTGGA TCTGGAGCCT GGCACCATGG ACTCTGTCAG GTCTGGACCC 
TTCGGCCAGA TCTTCAGACC AGACAACTTC GTGTTCGGCC AGAGTGGAGC CGGGAATAAC 
TGGGCCAAGG GCCACTACAC AGAGGGAGCC GAGCTGGTCG ACTCGGTCCT GGATGTGGTG 
AGGAAGGAGT CAGAGAGCTG TGACTGTCTC CAGGGCTTCC AGCTGACCCA CTCTCTGGGG 
GGCGGCACGG GGTCCGGGAT GGGCACCCTG CTCATCAGCA AGATCCGGGA AGAGTACCCA 
GACCGCATCA TGAACACCTT CAGCGTCATG CCCTCACCCA AGGTGTCAGA CACGGTGGTG 
GAGCCCTACA ACGCCACCCT CTCTGTCCAC CAGCTGGTGG AAAACACAGA TGAAACCTAC 
TCCATTGATA ACGAGGCCCT GTATGACATC TGCTTCCGCA CCCTGAAGCT GACCACCCCC 
ACCTACGGGG ACCTCAACCA CCTGGTGTCG GCCACCATGA GCGGGGTCAC CACCTGCCTG 
CGCTTCCCGG GCCAGCTGAA CGCAGACCTG CGCAAGCTGG CGGTGAACAT GGTGCCCTTC 
CCTCGCCTGC ACTTCTTCAT GCCCGGCTTC GCGCCCCTGA CCAGCCGGGG CAGCCAGCAG 
TACCGGGCGC TCACGGTGCC CGAGCTCACC CAGCAGATGT TCGACTCCAA GAACATGATG 
GCCGCCTGCG ACCCGCGCCA CGGCCGCTAC CTGACGGTGG CTGCCATCTT CCGGGGCCGC 
ATGTCCATGA AGGAGGTGGA CGAGCAGATG CTCAACGTGC AGAACAAGAA CAGCAGCTAC 
TTCGTGGAGT GGATCCCCAA CAACGTGAAG ACGGCCGTGT GCGACATCCC GCCCCGCGGC 
CTGAAGATGT CGGCCACCTT CATCGGCAAC AGCACGGCCA TCCAGGAGCT GTTCAAGCGC 
ATCTCCGAGC AGTTCACGGC CATGTTCCGG CGCAAGGCCT TCCTGCACTG GTACACGGGC 
GAGGGCATGG ACGAGATGGA GTTCACCGAG GCCGAGAGCA ACATGAACGA CCTGGTGTCC 
GAGTACCAGC AGTACCAGGA CGCCACGGCC GACGAACAAG GGGAGTTCGA GGAGGAGGAG 
GGCGAGGACG AGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
Acta neuropathologica communications7(1)68(2019 05)
Lee JH,Han JH,Kim H,Park SM,Joe EH,Jou I

Over-Expression of βII-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer.
Cells8(1)(2019 01)
Ruksha K,Mezheyeuski A,Nerovnya A,Bich T,Tur G,Gorgun J,Luduena R,Portyanko A

Defective kinesin binding of TUBB2A causes progressive spastic ataxia syndrome resembling sacsinopathy.
Human molecular genetics27(11)1892-1904(2018 06)
Sferra A,Fattori F,Rizza T,Flex E,Bellacchio E,Bruselles A,Petrini S,Cecchetti S,Teson M,Restaldi F,Ciolfi A,Santorelli FM,Zanni G,Barresi S,Castiglioni C,Tartaglia M,Bertini E

De novo pathogenic variant in TUBB2A presenting with arthrogryposis multiplex congenita, brain abnormalities, and severe developmental delay.
American journal of medical genetics. Part A173(10)2725-2730(2017 Oct)
Ejaz R,Lionel AC,Blaser S,Walker S,Scherer SW,Babul-Hirji R,Marshall CR,Stavropoulos DJ,Chitayat D

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TUBB2A cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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