TCN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TCN1
Entrez Gene ID	6947
Full Name	transcobalamin 1
Synonyms	HC,TC-1,TC1,TCI
General protein information	Preferred Names transcobalamin 1 Names transcobalamin-1 haptocorin haptocorrin protein R transcobalamin I (vitamin B12 binding protein, R binder family)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.1
Summary	This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008].
Disorder MIM:	189905

mRNA and Protein(s)

mRNA	Protein	Name
NM_001062.3	NP_001053.2	transcobalamin-1 precursor
NM_001062.4	NP_001053.2	transcobalamin-1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TCN1	NP_001053.2
Pan troglodytes (chimpanzee)	TCN1	XP_001136280.2
Macaca mulatta (Rhesus monkey)	TCN1	XP_001088817.1
Canis lupus familiaris (dog)	TCN1	XP_855361.1
Bos taurus (cattle)	TCN1	NP_001180034.1

Gene Ontology
Bibliography

Related articles in PubMed

A common
Hu Y, Raffield LM, Polfus LM, Moscati A, Nadkarni G, Preuss MH, Zhong X, Wei Q, Rich SS, Li Y, Wilson JG, Correa A, Loos RJF, Li B, Auer PL, Reiner AP,
Blood131(25)2859-2863(2018 06)

Vitamin B12 and placental expression of transcobalamin in pregnant adolescents.
Layden AJ, O'Brien KO, Pressman EK, Cooper EM, Kent TR, Finkelstein JL
Placenta451-7(2016 09)

Association study between genome-wide significant variants of vitamin B12 metabolism and gastric cancer in a han Chinese population.
Zhao L, Wei Y, Song A, Li Y
IUBMB life68(4)303-10(2016 Apr)

Transcriptomic profile reveals gender-specific molecular mechanisms driving multiple sclerosis progression.
Irizar H, Muñoz-Culla M, Sepúlveda L, Sáenz-Cuesta M, Prada Á, Castillo-Triviño T, Zamora-López G, López de Munain A, Olascoaga J, Otaegui D
PloS one9(2)e90482(2014)

Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
Keene KL, Chen WM, Chen F, Williams SR, Elkhatib SD, Hsu FC, Mychaleckyj JC, Doheny KF, Pugh EW, Ling H, Laurie CC, Gogarten SM, Madden EB, Worrall BB, Sale MM
Frontiers in public health2112(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TCN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TCN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28417	NM_001062.4 Latest version!	Homo sapiens transcobalamin 1 (TCN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$251.30 $359.00
View Old Accession Versions >>
OHu28417	NM_001062.3	Homo sapiens transcobalamin 1 (TCN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$179.50-$251.30 $359.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TCN1 ( NM_001062.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001053.2 Homo sapiens transcobalamin 1 (TCN1), mRNA.

Price & Availability↑

CloneID	OHu28417
Clone ID Related Accession (Same CDS sequence)	NM_001062.3 , NM_001062.4
Accession Version	NM_001062.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512835200000
Organism	Homo sapiens(human)
Product	transcobalamin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP370727.1, J05068.1, BC018632.1, BM769693.1 and BM818792.1. On Mar 22, 2007 this sequence version replaced NM_001062.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J05068.1, BC018632.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAGACAGT CACACCAGCT GCCCCTAGTG GGGCTCTTAC TGTTTTCTTT TATTCCAAGC 
CAACTATGCG AGATTTGTGA GGTAAGTGAA GAAAACTACA TCCGCCTAAA ACCTCTGTTG 
AATACAATGA TCCAGTCAAA CTATAACAGG GGAACCAGCG CTGTCAATGT TGTGTTGTCC 
CTCAAACTTG TTGGAATCCA GATCCAAACC CTGATGCAAA AGATGATCCA ACAAATCAAA 
TACAATGTGA AAAGCAGATT GTCAGATGTA AGCTCGGGAG AGCTTGCCTT GATTATACTG 
GCTTTGGGAG TATGTCGTAA CGCTGAGGAA AACTTAATAT ATGATTACCA CCTGATCGAC 
AAGCTAGAAA ATAAATTCCA AGCAGAAATT GAAAATATGG AAGCACACAA TGGCACTCCC 
CTGACTAACT ACTACCAGCT CAGCCTGGAC GTTTTGGCCT TGTGTCTGTT CAATGGGAAC 
TACTCAACCG CCGAAGTTGT CAACCACTTC ACTCCTGAAA ATAAAAACTA TTATTTTGGT 
AGCCAGTTCT CAGTAGATAC TGGTGCAATG GCTGTCCTGG CTCTGACCTG TGTGAAGAAG 
AGTCTAATAA ATGGGCAGAT CAAAGCAGAT GAAGGCAGTT TAAAGAACAT CAGTATTTAT 
ACAAAGTCAC TGGTAGAAAA GATTCTGTCT GAGAAAAAAG AAAATGGTCT CATTGGAAAC 
ACATTTAGCA CAGGAGAAGC CATGCAGGCC CTCTTTGTAT CATCAGACTA TTATAATGAA 
AATGACTGGA ATTGCCAACA AACTCTGAAT ACAGTGCTCA CGGAAATTTC TCAAGGAGCA 
TTCAGCAATC CAAACGCTGC AGCCCAGGTC TTACCTGCCC TGATGGGAAA GACCTTCTTG 
GATATTAACA AAGACTCTTC TTGCGTCTCT GCTTCAGGTA ACTTCAACAT CTCCGCTGAT 
GAGCCTATAA CTGTGACACC TCCTGACTCA CAATCATATA TCTCCGTCAA TTACTCTGTG 
AGAATCAATG AAACATATTT CACCAATGTC ACTGTGCTAA ATGGTTCTGT CTTCCTCAGT 
GTGATGGAGA AAGCCCAGAA AATGAATGAT ACTATATTTG GTTTCACAAT GGAGGAGCGC 
TCATGGGGGC CCTATATCAC CTGTATTCAG GGCCTATGTG CCAACAATAA TGACAGAACC 
TACTGGGAAC TTCTGAGTGG AGGCGAACCA CTGAGCCAAG GAGCTGGTAG TTACGTTGTC 
CGCAATGGAG AAAACTTGGA GGTTCGCTGG AGCAAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001053.2
CDS	99..1400
Translation	MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY

Target ORF information:

RefSeq Version	NM_001062.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transcobalamin 1 (TCN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001062.3

ORF Insert Sequence:

ATGAGACAGT CACACCAGCT GCCCCTAGTG GGGCTCTTAC TGTTTTCTTT TATTCCAAGC 
CAACTATGCG AGATTTGTGA GGTAAGTGAA GAAAACTACA TCCGCCTAAA ACCTCTGTTG 
AATACAATGA TCCAGTCAAA CTATAACAGG GGAACCAGCG CTGTCAATGT TGTGTTGTCC 
CTCAAACTTG TTGGAATCCA GATCCAAACC CTGATGCAAA AGATGATCCA ACAAATCAAA 
TACAATGTGA AAAGCAGATT GTCAGATGTA AGCTCGGGAG AGCTTGCCTT GATTATACTG 
GCTTTGGGAG TATGTCGTAA CGCTGAGGAA AACTTAATAT ATGATTACCA CCTGATCGAC 
AAGCTAGAAA ATAAATTCCA AGCAGAAATT GAAAATATGG AAGCACACAA TGGCACTCCC 
CTGACTAACT ACTACCAGCT CAGCCTGGAC GTTTTGGCCT TGTGTCTGTT CAATGGGAAC 
TACTCAACCG CCGAAGTTGT CAACCACTTC ACTCCTGAAA ATAAAAACTA TTATTTTGGT 
AGCCAGTTCT CAGTAGATAC TGGTGCAATG GCTGTCCTGG CTCTGACCTG TGTGAAGAAG 
AGTCTAATAA ATGGGCAGAT CAAAGCAGAT GAAGGCAGTT TAAAGAACAT CAGTATTTAT 
ACAAAGTCAC TGGTAGAAAA GATTCTGTCT GAGAAAAAAG AAAATGGTCT CATTGGAAAC 
ACATTTAGCA CAGGAGAAGC CATGCAGGCC CTCTTTGTAT CATCAGACTA TTATAATGAA 
AATGACTGGA ATTGCCAACA AACTCTGAAT ACAGTGCTCA CGGAAATTTC TCAAGGAGCA 
TTCAGCAATC CAAACGCTGC AGCCCAGGTC TTACCTGCCC TGATGGGAAA GACCTTCTTG 
GATATTAACA AAGACTCTTC TTGCGTCTCT GCTTCAGGTA ACTTCAACAT CTCCGCTGAT 
GAGCCTATAA CTGTGACACC TCCTGACTCA CAATCATATA TCTCCGTCAA TTACTCTGTG 
AGAATCAATG AAACATATTT CACCAATGTC ACTGTGCTAA ATGGTTCTGT CTTCCTCAGT 
GTGATGGAGA AAGCCCAGAA AATGAATGAT ACTATATTTG GTTTCACAAT GGAGGAGCGC 
TCATGGGGGC CCTATATCAC CTGTATTCAG GGCCTATGTG CCAACAATAA TGACAGAACC 
TACTGGGAAC TTCTGAGTGG AGGCGAACCA CTGAGCCAAG GAGCTGGTAG TTACGTTGTC 
CGCAATGGAG AAAACTTGGA GGTTCGCTGG AGCAAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TCN1 ( NM_001062.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001053.2 Homo sapiens transcobalamin 1 (TCN1), mRNA.

Price & Availability↑

CloneID	OHu28417
Clone ID Related Accession (Same CDS sequence)	NM_001062.3 , NM_001062.4
Accession Version	NM_001062.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569427200000
Organism	Homo sapiens(human)
Product	transcobalamin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from J05068.1, BC018632.1, BM769693.1 and BM818792.1. On Nov 23, 2018 this sequence version replaced NM_001062.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018632.1, J05068.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000257264.4/ ENSP00000257264.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGACAGT CACACCAGCT GCCCCTAGTG GGGCTCTTAC TGTTTTCTTT TATTCCAAGC 
CAACTATGCG AGATTTGTGA GGTAAGTGAA GAAAACTACA TCCGCCTAAA ACCTCTGTTG 
AATACAATGA TCCAGTCAAA CTATAACAGG GGAACCAGCG CTGTCAATGT TGTGTTGTCC 
CTCAAACTTG TTGGAATCCA GATCCAAACC CTGATGCAAA AGATGATCCA ACAAATCAAA 
TACAATGTGA AAAGCAGATT GTCAGATGTA AGCTCGGGAG AGCTTGCCTT GATTATACTG 
GCTTTGGGAG TATGTCGTAA CGCTGAGGAA AACTTAATAT ATGATTACCA CCTGATCGAC 
AAGCTAGAAA ATAAATTCCA AGCAGAAATT GAAAATATGG AAGCACACAA TGGCACTCCC 
CTGACTAACT ACTACCAGCT CAGCCTGGAC GTTTTGGCCT TGTGTCTGTT CAATGGGAAC 
TACTCAACCG CCGAAGTTGT CAACCACTTC ACTCCTGAAA ATAAAAACTA TTATTTTGGT 
AGCCAGTTCT CAGTAGATAC TGGTGCAATG GCTGTCCTGG CTCTGACCTG TGTGAAGAAG 
AGTCTAATAA ATGGGCAGAT CAAAGCAGAT GAAGGCAGTT TAAAGAACAT CAGTATTTAT 
ACAAAGTCAC TGGTAGAAAA GATTCTGTCT GAGAAAAAAG AAAATGGTCT CATTGGAAAC 
ACATTTAGCA CAGGAGAAGC CATGCAGGCC CTCTTTGTAT CATCAGACTA TTATAATGAA 
AATGACTGGA ATTGCCAACA AACTCTGAAT ACAGTGCTCA CGGAAATTTC TCAAGGAGCA 
TTCAGCAATC CAAACGCTGC AGCCCAGGTC TTACCTGCCC TGATGGGAAA GACCTTCTTG 
GATATTAACA AAGACTCTTC TTGCGTCTCT GCTTCAGGTA ACTTCAACAT CTCCGCTGAT 
GAGCCTATAA CTGTGACACC TCCTGACTCA CAATCATATA TCTCCGTCAA TTACTCTGTG 
AGAATCAATG AAACATATTT CACCAATGTC ACTGTGCTAA ATGGTTCTGT CTTCCTCAGT 
GTGATGGAGA AAGCCCAGAA AATGAATGAT ACTATATTTG GTTTCACAAT GGAGGAGCGC 
TCATGGGGGC CCTATATCAC CTGTATTCAG GGCCTATGTG CCAACAATAA TGACAGAACC 
TACTGGGAAC TTCTGAGTGG AGGCGAACCA CTGAGCCAAG GAGCTGGTAG TTACGTTGTC 
CGCAATGGAG AAAACTTGGA GGTTCGCTGG AGCAAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001053.2
CDS	18..1319
Translation	MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY

Target ORF information:

RefSeq Version	NM_001062.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transcobalamin 1 (TCN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001062.4

ORF Insert Sequence:

ATGAGACAGT CACACCAGCT GCCCCTAGTG GGGCTCTTAC TGTTTTCTTT TATTCCAAGC 
CAACTATGCG AGATTTGTGA GGTAAGTGAA GAAAACTACA TCCGCCTAAA ACCTCTGTTG 
AATACAATGA TCCAGTCAAA CTATAACAGG GGAACCAGCG CTGTCAATGT TGTGTTGTCC 
CTCAAACTTG TTGGAATCCA GATCCAAACC CTGATGCAAA AGATGATCCA ACAAATCAAA 
TACAATGTGA AAAGCAGATT GTCAGATGTA AGCTCGGGAG AGCTTGCCTT GATTATACTG 
GCTTTGGGAG TATGTCGTAA CGCTGAGGAA AACTTAATAT ATGATTACCA CCTGATCGAC 
AAGCTAGAAA ATAAATTCCA AGCAGAAATT GAAAATATGG AAGCACACAA TGGCACTCCC 
CTGACTAACT ACTACCAGCT CAGCCTGGAC GTTTTGGCCT TGTGTCTGTT CAATGGGAAC 
TACTCAACCG CCGAAGTTGT CAACCACTTC ACTCCTGAAA ATAAAAACTA TTATTTTGGT 
AGCCAGTTCT CAGTAGATAC TGGTGCAATG GCTGTCCTGG CTCTGACCTG TGTGAAGAAG 
AGTCTAATAA ATGGGCAGAT CAAAGCAGAT GAAGGCAGTT TAAAGAACAT CAGTATTTAT 
ACAAAGTCAC TGGTAGAAAA GATTCTGTCT GAGAAAAAAG AAAATGGTCT CATTGGAAAC 
ACATTTAGCA CAGGAGAAGC CATGCAGGCC CTCTTTGTAT CATCAGACTA TTATAATGAA 
AATGACTGGA ATTGCCAACA AACTCTGAAT ACAGTGCTCA CGGAAATTTC TCAAGGAGCA 
TTCAGCAATC CAAACGCTGC AGCCCAGGTC TTACCTGCCC TGATGGGAAA GACCTTCTTG 
GATATTAACA AAGACTCTTC TTGCGTCTCT GCTTCAGGTA ACTTCAACAT CTCCGCTGAT 
GAGCCTATAA CTGTGACACC TCCTGACTCA CAATCATATA TCTCCGTCAA TTACTCTGTG 
AGAATCAATG AAACATATTT CACCAATGTC ACTGTGCTAA ATGGTTCTGT CTTCCTCAGT 
GTGATGGAGA AAGCCCAGAA AATGAATGAT ACTATATTTG GTTTCACAAT GGAGGAGCGC 
TCATGGGGGC CCTATATCAC CTGTATTCAG GGCCTATGTG CCAACAATAA TGACAGAACC 
TACTGGGAAC TTCTGAGTGG AGGCGAACCA CTGAGCCAAG GAGCTGGTAG TTACGTTGTC 
CGCAATGGAG AAAACTTGGA GGTTCGCTGG AGCAAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A common
Blood131(25)2859-2863(2018 06)
Hu Y,Raffield LM,Polfus LM,Moscati A,Nadkarni G,Preuss MH,Zhong X,Wei Q,Rich SS,Li Y,Wilson JG,Correa A,Loos RJF,Li B,Auer PL,Reiner AP,

Vitamin B12 and placental expression of transcobalamin in pregnant adolescents.
Placenta451-7(2016 09)
Layden AJ,O'Brien KO,Pressman EK,Cooper EM,Kent TR,Finkelstein JL

Association study between genome-wide significant variants of vitamin B12 metabolism and gastric cancer in a han Chinese population.
IUBMB life68(4)303-10(2016 Apr)
Zhao L,Wei Y,Song A,Li Y

Transcriptomic profile reveals gender-specific molecular mechanisms driving multiple sclerosis progression.
PloS one9(2)e90482(2014)
Irizar H,Muñoz-Culla M,Sepúlveda L,Sáenz-Cuesta M,Prada Á,Castillo-Triviño T,Zamora-López G,López de Munain A,Olascoaga J,Otaegui D

Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
Frontiers in public health2112(2014)
Keene KL,Chen WM,Chen F,Williams SR,Elkhatib SD,Hsu FC,Mychaleckyj JC,Doheny KF,Pugh EW,Ling H,Laurie CC,Gogarten SM,Madden EB,Worrall BB,Sale MM

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TCN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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