| Gene Symbol | SRY |
| Entrez Gene ID | 6736 |
| Full Name | sex determining region Y |
| Synonyms | SRXX1,SRXY1,TDF,TDY |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | 46XY sex reversal 1, 400044 (3); 46XX sex reversal 1, 400045 (3) |
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SRY cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following SRY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SRY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu28314 Clone ID Related Accession (Same CDS sequence) NM_003140.2 , NM_003140.3 Accession Version NM_003140.2 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 615bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1550851200000 Organism Homo sapiens(human) Product sex-determining region Y protein Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006040.3 and L10101.1. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2013 this sequence version replaced NM_003140.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601ATGCAATCAT ATGCTTCTGC TATGTTAAGC GTATTCAACA GCGATGATTA CAGTCCAGCT
GTGCAAGAGA ATATTCCCGC TCTCCGGAGA AGCTCTTCCT TCCTTTGCAC TGAAAGCTGT
AACTCTAAGT ATCAGTGTGA AACGGGAGAA AACAGTAAAG GCAACGTCCA GGATAGAGTG
AAGCGACCCA TGAACGCATT CATCGTGTGG TCTCGCGATC AGAGGCGCAA GATGGCTCTA
GAGAATCCCA GAATGCGAAA CTCAGAGATC AGCAAGCAGC TGGGATACCA GTGGAAAATG
CTTACTGAAG CCGAAAAATG GCCATTCTTC CAGGAGGCAC AGAAATTACA GGCCATGCAC
AGAGAGAAAT ACCCGAATTA TAAGTATCGA CCTCGTCGGA AGGCGAAGAT GCTGCCGAAG
AATTGCAGTT TGCTTCCCGC AGATCCCGCT TCGGTACTCT GCAGCGAAGT GCAACTGGAC
AACAGGTTGT ACAGGGATGA CTGTACGAAA GCCACACACT CAAGAATGGA GCACCAGCTA
GGCCACTTAC CGCCCATCAA CGCAGCCAGC TCACCGCAGC AACGGGACCG CTACAGCCAC
TGGACAAAGC TGTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_003131.1 CDS 139..753 Translation 
Target ORF information:
RefSeq Version NM_003140.2 Organism Homo sapiens(human) Definition Homo sapiens sex determining region Y (SRY), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_003140.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGCAATCAT ATGCTTCTGC TATGTTAAGC GTATTCAACA GCGATGATTA CAGTCCAGCT
GTGCAAGAGA ATATTCCCGC TCTCCGGAGA AGCTCTTCCT TCCTTTGCAC TGAAAGCTGT
AACTCTAAGT ATCAGTGTGA AACGGGAGAA AACAGTAAAG GCAACGTCCA GGATAGAGTG
AAGCGACCCA TGAACGCATT CATCGTGTGG TCTCGCGATC AGAGGCGCAA GATGGCTCTA
GAGAATCCCA GAATGCGAAA CTCAGAGATC AGCAAGCAGC TGGGATACCA GTGGAAAATG
CTTACTGAAG CCGAAAAATG GCCATTCTTC CAGGAGGCAC AGAAATTACA GGCCATGCAC
AGAGAGAAAT ACCCGAATTA TAAGTATCGA CCTCGTCGGA AGGCGAAGAT GCTGCCGAAG
AATTGCAGTT TGCTTCCCGC AGATCCCGCT TCGGTACTCT GCAGCGAAGT GCAACTGGAC
AACAGGTTGT ACAGGGATGA CTGTACGAAA GCCACACACT CAAGAATGGA GCACCAGCTA
GGCCACTTAC CGCCCATCAA CGCAGCCAGC TCACCGCAGC AACGGGACCG CTACAGCCAC
TGGACAAAGC TGTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu28314 Clone ID Related Accession (Same CDS sequence) NM_003140.2 , NM_003140.3 Accession Version NM_003140.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 615bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1575820800000 Organism Homo sapiens(human) Product sex-determining region Y protein Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L10101.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_003140.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: L10101.1, BC074923.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000383070.2/ ENSP00000372547.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601ATGCAATCAT ATGCTTCTGC TATGTTAAGC GTATTCAACA GCGATGATTA CAGTCCAGCT
GTGCAAGAGA ATATTCCCGC TCTCCGGAGA AGCTCTTCCT TCCTTTGCAC TGAAAGCTGT
AACTCTAAGT ATCAGTGTGA AACGGGAGAA AACAGTAAAG GCAACGTCCA GGATAGAGTG
AAGCGACCCA TGAACGCATT CATCGTGTGG TCTCGCGATC AGAGGCGCAA GATGGCTCTA
GAGAATCCCA GAATGCGAAA CTCAGAGATC AGCAAGCAGC TGGGATACCA GTGGAAAATG
CTTACTGAAG CCGAAAAATG GCCATTCTTC CAGGAGGCAC AGAAATTACA GGCCATGCAC
AGAGAGAAAT ACCCGAATTA TAAGTATCGA CCTCGTCGGA AGGCGAAGAT GCTGCCGAAG
AATTGCAGTT TGCTTCCCGC AGATCCCGCT TCGGTACTCT GCAGCGAAGT GCAACTGGAC
AACAGGTTGT ACAGGGATGA CTGTACGAAA GCCACACACT CAAGAATGGA GCACCAGCTA
GGCCACTTAC CGCCCATCAA CGCAGCCAGC TCACCGCAGC AACGGGACCG CTACAGCCAC
TGGACAAAGC TGTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_003131.1 CDS 80..694 Translation
Target ORF information:
RefSeq Version NM_003140.3 Organism Homo sapiens(human) Definition Homo sapiens sex determining region Y (SRY), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_003140.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGCAATCAT ATGCTTCTGC TATGTTAAGC GTATTCAACA GCGATGATTA CAGTCCAGCT
GTGCAAGAGA ATATTCCCGC TCTCCGGAGA AGCTCTTCCT TCCTTTGCAC TGAAAGCTGT
AACTCTAAGT ATCAGTGTGA AACGGGAGAA AACAGTAAAG GCAACGTCCA GGATAGAGTG
AAGCGACCCA TGAACGCATT CATCGTGTGG TCTCGCGATC AGAGGCGCAA GATGGCTCTA
GAGAATCCCA GAATGCGAAA CTCAGAGATC AGCAAGCAGC TGGGATACCA GTGGAAAATG
CTTACTGAAG CCGAAAAATG GCCATTCTTC CAGGAGGCAC AGAAATTACA GGCCATGCAC
AGAGAGAAAT ACCCGAATTA TAAGTATCGA CCTCGTCGGA AGGCGAAGAT GCTGCCGAAG
AATTGCAGTT TGCTTCCCGC AGATCCCGCT TCGGTACTCT GCAGCGAAGT GCAACTGGAC
AACAGGTTGT ACAGGGATGA CTGTACGAAA GCCACACACT CAAGAATGGA GCACCAGCTA
GGCCACTTAC CGCCCATCAA CGCAGCCAGC TCACCGCAGC AACGGGACCG CTACAGCCAC
TGGACAAAGC TGTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Y chromosome loss is associated with age-related male patients with abdominal aortic aneurysms.
Clinical interventions in aging141227-1241(2019)
Tang D,Han Y,Lun Y,Jiang H,Xin S,Duan Z,Zhang J
Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma.
Cancer letters41020-31(2017 12)
Liu C,Ren YF,Dong J,Ke MY,Ma F,Monga SPS,Wu R,Lv Y,Zhang XF
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Proceedings of the National Academy of Sciences of the United States of America106(18)7507-12(2009 May)
Calvo SE,Pagliarini DJ,Mootha VK
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