| Gene Symbol | SNRPD3 |
| Entrez Gene ID | 6634 |
| Full Name | small nuclear ribonucleoprotein D3 polypeptide |
| Synonyms | SMD3,Sm-D3 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. |
| Disorder MIM: |
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SNRPD3 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following SNRPD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNRPD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu11399 Clone ID Related Accession (Same CDS sequence) NM_004175.5 , NM_004175.4 , NM_001278656.1 Accession Version NM_004175.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 381bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1562256000000 Organism Homo sapiens(human) Product small nuclear ribonucleoprotein Sm D3 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000457.2, CN286602.1 and AP000356.1. On Nov 23, 2018 this sequence version replaced NM_004175.4. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.12982.1, SRR1803615.212856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000215829.8/ ENSP00000215829.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC
ATCTTTCAAA AGCGAAGATA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_004166.1 CDS 92..472 Translation 
Target ORF information:
RefSeq Version NM_004175.5 Organism Homo sapiens(human) Definition Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_004175.5
ORF Insert Sequence:
1
61
121
181
241
301
361ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC
ATCTTTCAAA AGCGAAGATA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu11399 Clone ID Related Accession (Same CDS sequence) NM_004175.5 , NM_004175.4 , NM_001278656.1 Accession Version NM_004175.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 381bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506787200000 Organism Homo sapiens(human) Product small nuclear ribonucleoprotein Sm D3 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000356.1, BC000457.2 and CN286602.1. On Jul 6, 2013 this sequence version replaced NM_004175.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.212856.1, SRR1803613.246654.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC
ATCTTTCAAA AGCGAAGATA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_004166.1 CDS 441..821 Translation
Target ORF information:
RefSeq Version NM_004175.4 Organism Homo sapiens(human) Definition Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_004175.4
ORF Insert Sequence:
1
61
121
181
241
301
361ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC
ATCTTTCAAA AGCGAAGATA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu11399 Clone ID Related Accession (Same CDS sequence) NM_004175.5 , NM_004175.4 , NM_001278656.1 Accession Version NM_001278656.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 381bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1562256000000 Organism Homo sapiens(human) Product small nuclear ribonucleoprotein Sm D3 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000356.1, BY993733.1 and CN286602.1. Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.11132.1, BU176035.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC
ATCTTTCAAA AGCGAAGATA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001265585.1 CDS 427..807 Translation
Target ORF information:
RefSeq Version NM_001278656.1 Organism Homo sapiens(human) Definition Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001278656.1
ORF Insert Sequence:
1
61
121
181
241
301
361ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC
ATCTTTCAAA AGCGAAGATA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell170(4)701-713.e11(2017 Aug)
Bertram K,Agafonov DE,Dybkov O,Haselbach D,Leelaram MN,Will CL,Urlaub H,Kastner B,Lührmann R,Stark H
Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature542(7641)318-323(2017 02)
Bertram K,Agafonov DE,Liu WT,Dybkov O,Will CL,Hartmuth K,Urlaub H,Kastner B,Stark H,Lührmann R
Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)
Agafonov DE,Kastner B,Dybkov O,Hofele RV,Liu WT,Urlaub H,Lührmann R,Stark H
Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
eLife4(2015 Jan)
Kondo Y,Oubridge C,van Roon AM,Nagai K
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,Déret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN
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