ELOVL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ELOVL1
Entrez Gene ID	64834
Full Name	ELOVL fatty acid elongase 1
Synonyms	CGI-88,Ssc1
General protein information	Preferred Names ELOVL fatty acid elongase 1 Names elongation of very long chain fatty acids protein 1 3-keto acyl-CoA synthase ELOVL1 ELOVL FA elongase 1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 very long chain 3-ketoacyl-CoA synthase 1 very long chain 3-oxoacyl-CoA synthase 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.2
Disorder MIM:	611813

mRNA and Protein(s)

mRNA	Protein	Name
NM_022821.3	NP_073732.1	elongation of very long chain fatty acids protein 1 isoform 1
NM_001256402.1	NP_001243331.1	elongation of very long chain fatty acids protein 1 isoform 3
NM_022821.4	NP_073732.1	elongation of very long chain fatty acids protein 1 isoform 1
NM_001256402.2	NP_001243331.1	elongation of very long chain fatty acids protein 1 isoform 3
NM_001256399.1	NP_001243328.1	elongation of very long chain fatty acids protein 1 isoform 1
NM_001256401.1	NP_001243330.1	elongation of very long chain fatty acids protein 1 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	ELOVL1	NP_073732.1
Bos taurus (cattle)	ELOVL1	NP_001029875.1
Danio rerio (zebrafish)	elovl1b	NP_998581.1
Macaca mulatta (Rhesus monkey)	ELOVL1	XP_001093310.1
Mus musculus (house mouse)	Elovl1	NP_062295.1
Rattus norvegicus (Norway rat)	Elovl1	NP_001037740.1
Gallus gallus (chicken)	ELOVL1	NP_001012616.1
Danio rerio (zebrafish)	elovl1a	NP_001005989.1
Pan troglodytes (chimpanzee)	ELOVL1	XP_003308079.1
Xenopus tropicalis (tropical clawed frog)	elovl1	NP_001016644.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004373	XP_313656.5
Drosophila melanogaster (fruit fly)	CG31522	NP_001246906.1
Canis lupus familiaris (dog)	ELOVL1	XP_003639577.1

Gene Ontology
Bibliography

Related articles in PubMed

Dominant
Kutkowska-Kaźmierczak A, Rydzanicz M, Chlebowski A, Kłosowska-Kosicka K, Mika A, Gruchota J, Jurkiewicz E, Kowalewski C, Pollak A, Stradomska TJ, Kmieć T, Jakubowski R, Gasperowicz P, Walczak A, Śladowski D, Jankowska-Steifer E, Korniszewski L, Kosińska J, Obersztyn E, Nowak W, Śledziński T, Dziembowski A, Płoski R
Journal of medical genetics55(6)408-414(2018 06)

Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis.
Schackmann MJ, Ofman R, Dijkstra IM, Wanders RJ, Kemp S
Biochimica et biophysica acta1851(2)231-7(2015 Feb)

Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid.
Sassa T, Wakashima T, Ohno Y, Kihara A
Journal of lipid research55(3)524-30(2014 Mar)

The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.
Hartmann D, Wegner MS, Wanger RA, Ferreirós N, Schreiber Y, Lucks J, Schiffmann S, Geisslinger G, Grösch S
The international journal of biochemistry & cell biology45(7)1195-203(2013 Jul)

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A
Proceedings of the National Academy of Sciences of the United States of America107(43)18439-44(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ELOVL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ELOVL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29192	NM_001256401.1 Latest version!	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu13865	NM_022821.4 Latest version!	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu13865	NM_001256399.1 Latest version!	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu29168	NM_001256402.2 Latest version!	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu13865	NM_022821.3	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu29168	NM_001256402.1	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ELOVL1 ( NM_001256401.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243330.1 Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu29192
Clone ID Related Accession (Same CDS sequence)	NM_001256401.1
Accession Version	NM_001256401.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	elongation of very long chain fatty acids protein 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP281965.1, AK298163.1 and AA635780.1. Transcript Variant: This variant (3) lacks an alternate, in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK298163.1, ERR279868.652.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCTG TTGTGAACTT GTACCAAGAG GTGATGAAGC ACGCAGATCC CCGGATCCAG 
GGCTACCCTC TGATGGGGTC CCCCTTGCTA ATGACCTCCA TTCTCCTGAC CTACGTGTAC 
TTCGTTCTCT CACTTGGGCC TCGCATCATG GCTAATCGGA AGCCCTTCCA GCTCCGTGGC 
TTCATGATTG TCTACAACTT CTCACTGGTG GCACTCTCCC TCTACATTGT CTATGAGATG 
GTTCGGGTGG CCTGGCTCTT CCTCTTCTCC AAGTTCATTG AGCTGATGGA CACAGTGATC 
TTTATTCTCC GAAAGAAAGA CGGGCAGGTG ACCTTCCTAC ATGTCTTCCA TCACTCTGTG 
CTTCCCTGGA GCTGGTGGTG GGGGGTAAAG ATTGCCCCGG GAGGAATGGG CTCTTTCCAT 
GCCATGATAA ACTCTTCCGT GCATGTCATA ATGTACCTGT ACTACGGATT ATCTGCCTTT 
GGCCCTGTGG CACAACCCTA CCTTTGGTGG AAAAAGCACA TGACAGCCAT TCAGCTGATC 
CAGTTTGTCC TGGTCTCACT GCACATCTCC CAGTACTACT TTATGTCCAG CTGTAACTAC 
CAGTACCCAG TCATTATTCA CCTCATCTGG ATGTATGGCA CCATCTTCTT CATGCTGTTC 
TCCAACTTCT GGTATCACTC TTATACCAAG GGCAAGCGGC TGCCCCGTGC ACTTCAGCAA 
AATGGAGCTC CAGGTATTGC CAAGGTCAAG GCCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243330.1
CDS	175..933
Translation	MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN

Target ORF information:

RefSeq Version	NM_001256401.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256401.1

ORF Insert Sequence:

ATGGAGGCTG TTGTGAACTT GTACCAAGAG GTGATGAAGC ACGCAGATCC CCGGATCCAG 
GGCTACCCTC TGATGGGGTC CCCCTTGCTA ATGACCTCCA TTCTCCTGAC CTACGTGTAC 
TTCGTTCTCT CACTTGGGCC TCGCATCATG GCTAATCGGA AGCCCTTCCA GCTCCGTGGC 
TTCATGATTG TCTACAACTT CTCACTGGTG GCACTCTCCC TCTACATTGT CTATGAGATG 
GTTCGGGTGG CCTGGCTCTT CCTCTTCTCC AAGTTCATTG AGCTGATGGA CACAGTGATC 
TTTATTCTCC GAAAGAAAGA CGGGCAGGTG ACCTTCCTAC ATGTCTTCCA TCACTCTGTG 
CTTCCCTGGA GCTGGTGGTG GGGGGTAAAG ATTGCCCCGG GAGGAATGGG CTCTTTCCAT 
GCCATGATAA ACTCTTCCGT GCATGTCATA ATGTACCTGT ACTACGGATT ATCTGCCTTT 
GGCCCTGTGG CACAACCCTA CCTTTGGTGG AAAAAGCACA TGACAGCCAT TCAGCTGATC 
CAGTTTGTCC TGGTCTCACT GCACATCTCC CAGTACTACT TTATGTCCAG CTGTAACTAC 
CAGTACCCAG TCATTATTCA CCTCATCTGG ATGTATGGCA CCATCTTCTT CATGCTGTTC 
TCCAACTTCT GGTATCACTC TTATACCAAG GGCAAGCGGC TGCCCCGTGC ACTTCAGCAA 
AATGGAGCTC CAGGTATTGC CAAGGTCAAG GCCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELOVL1 ( NM_022821.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_073732.1 Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13865
Clone ID Related Accession (Same CDS sequence)	NM_022821.3 , NM_022821.4 , NM_001256399.1
Accession Version	NM_022821.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506873600000
Organism	Homo sapiens(human)
Product	elongation of very long chain fatty acids protein 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP281965.1, AL537185.3, BC000618.2 and AA635780.1. On Jan 24, 2012 this sequence version replaced NM_022821.2. Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.236901.1, SRR1163655.258890.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCTG TTGTGAACTT GTACCAAGAG GTGATGAAGC ACGCAGATCC CCGGATCCAG 
GGCTACCCTC TGATGGGGTC CCCCTTGCTA ATGACCTCCA TTCTCCTGAC CTACGTGTAC 
TTCGTTCTCT CACTTGGGCC TCGCATCATG GCTAATCGGA AGCCCTTCCA GCTCCGTGGC 
TTCATGATTG TCTACAACTT CTCACTGGTG GCACTCTCCC TCTACATTGT CTATGAGTTC 
CTGATGTCGG GCTGGCTGAG CACCTATACC TGGCGCTGTG ACCCTGTGGA CTATTCCAAC 
AGCCCTGAGG CACTTAGGAT GGTTCGGGTG GCCTGGCTCT TCCTCTTCTC CAAGTTCATT 
GAGCTGATGG ACACAGTGAT CTTTATTCTC CGAAAGAAAG ACGGGCAGGT GACCTTCCTA 
CATGTCTTCC ATCACTCTGT GCTTCCCTGG AGCTGGTGGT GGGGGGTAAA GATTGCCCCG 
GGAGGAATGG GCTCTTTCCA TGCCATGATA AACTCTTCCG TGCATGTCAT AATGTACCTG 
TACTACGGAT TATCTGCCTT TGGCCCTGTG GCACAACCCT ACCTTTGGTG GAAAAAGCAC 
ATGACAGCCA TTCAGCTGAT CCAGTTTGTC CTGGTCTCAC TGCACATCTC CCAGTACTAC 
TTTATGTCCA GCTGTAACTA CCAGTACCCA GTCATTATTC ACCTCATCTG GATGTATGGC 
ACCATCTTCT TCATGCTGTT CTCCAACTTC TGGTATCACT CTTATACCAA GGGCAAGCGG 
CTGCCCCGTG CACTTCAGCA AAATGGAGCT CCAGGTATTG CCAAGGTCAA GGCCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073732.1
CDS	175..1014
Translation	MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN

Target ORF information:

RefSeq Version	NM_022821.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022821.3

ORF Insert Sequence:

ATGGAGGCTG TTGTGAACTT GTACCAAGAG GTGATGAAGC ACGCAGATCC CCGGATCCAG 
GGCTACCCTC TGATGGGGTC CCCCTTGCTA ATGACCTCCA TTCTCCTGAC CTACGTGTAC 
TTCGTTCTCT CACTTGGGCC TCGCATCATG GCTAATCGGA AGCCCTTCCA GCTCCGTGGC 
TTCATGATTG TCTACAACTT CTCACTGGTG GCACTCTCCC TCTACATTGT CTATGAGTTC 
CTGATGTCGG GCTGGCTGAG CACCTATACC TGGCGCTGTG ACCCTGTGGA CTATTCCAAC 
AGCCCTGAGG CACTTAGGAT GGTTCGGGTG GCCTGGCTCT TCCTCTTCTC CAAGTTCATT 
GAGCTGATGG ACACAGTGAT CTTTATTCTC CGAAAGAAAG ACGGGCAGGT GACCTTCCTA 
CATGTCTTCC ATCACTCTGT GCTTCCCTGG AGCTGGTGGT GGGGGGTAAA GATTGCCCCG 
GGAGGAATGG GCTCTTTCCA TGCCATGATA AACTCTTCCG TGCATGTCAT AATGTACCTG 
TACTACGGAT TATCTGCCTT TGGCCCTGTG GCACAACCCT ACCTTTGGTG GAAAAAGCAC 
ATGACAGCCA TTCAGCTGAT CCAGTTTGTC CTGGTCTCAC TGCACATCTC CCAGTACTAC 
TTTATGTCCA GCTGTAACTA CCAGTACCCA GTCATTATTC ACCTCATCTG GATGTATGGC 
ACCATCTTCT TCATGCTGTT CTCCAACTTC TGGTATCACT CTTATACCAA GGGCAAGCGG 
CTGCCCCGTG CACTTCAGCA AAATGGAGCT CCAGGTATTG CCAAGGTCAA GGCCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELOVL1 ( NM_022821.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_073732.1 Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13865
Clone ID Related Accession (Same CDS sequence)	NM_022821.3 , NM_022821.4 , NM_001256399.1
Accession Version	NM_022821.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	elongation of very long chain fatty acids protein 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL537185.3, BC000618.2 and AA635780.1. On Nov 22, 2018 this sequence version replaced NM_022821.3. Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK222498.1, SRR3476690.108947.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372458.8/ ENSP00000361536.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCTG TTGTGAACTT GTACCAAGAG GTGATGAAGC ACGCAGATCC CCGGATCCAG 
GGCTACCCTC TGATGGGGTC CCCCTTGCTA ATGACCTCCA TTCTCCTGAC CTACGTGTAC 
TTCGTTCTCT CACTTGGGCC TCGCATCATG GCTAATCGGA AGCCCTTCCA GCTCCGTGGC 
TTCATGATTG TCTACAACTT CTCACTGGTG GCACTCTCCC TCTACATTGT CTATGAGTTC 
CTGATGTCGG GCTGGCTGAG CACCTATACC TGGCGCTGTG ACCCTGTGGA CTATTCCAAC 
AGCCCTGAGG CACTTAGGAT GGTTCGGGTG GCCTGGCTCT TCCTCTTCTC CAAGTTCATT 
GAGCTGATGG ACACAGTGAT CTTTATTCTC CGAAAGAAAG ACGGGCAGGT GACCTTCCTA 
CATGTCTTCC ATCACTCTGT GCTTCCCTGG AGCTGGTGGT GGGGGGTAAA GATTGCCCCG 
GGAGGAATGG GCTCTTTCCA TGCCATGATA AACTCTTCCG TGCATGTCAT AATGTACCTG 
TACTACGGAT TATCTGCCTT TGGCCCTGTG GCACAACCCT ACCTTTGGTG GAAAAAGCAC 
ATGACAGCCA TTCAGCTGAT CCAGTTTGTC CTGGTCTCAC TGCACATCTC CCAGTACTAC 
TTTATGTCCA GCTGTAACTA CCAGTACCCA GTCATTATTC ACCTCATCTG GATGTATGGC 
ACCATCTTCT TCATGCTGTT CTCCAACTTC TGGTATCACT CTTATACCAA GGGCAAGCGG 
CTGCCCCGTG CACTTCAGCA AAATGGAGCT CCAGGTATTG CCAAGGTCAA GGCCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073732.1
CDS	112..951
Translation	MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN

Target ORF information:

RefSeq Version	NM_022821.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022821.4

ORF Insert Sequence:

ATGGAGGCTG TTGTGAACTT GTACCAAGAG GTGATGAAGC ACGCAGATCC CCGGATCCAG 
GGCTACCCTC TGATGGGGTC CCCCTTGCTA ATGACCTCCA TTCTCCTGAC CTACGTGTAC 
TTCGTTCTCT CACTTGGGCC TCGCATCATG GCTAATCGGA AGCCCTTCCA GCTCCGTGGC 
TTCATGATTG TCTACAACTT CTCACTGGTG GCACTCTCCC TCTACATTGT CTATGAGTTC 
CTGATGTCGG GCTGGCTGAG CACCTATACC TGGCGCTGTG ACCCTGTGGA CTATTCCAAC 
AGCCCTGAGG CACTTAGGAT GGTTCGGGTG GCCTGGCTCT TCCTCTTCTC CAAGTTCATT 
GAGCTGATGG ACACAGTGAT CTTTATTCTC CGAAAGAAAG ACGGGCAGGT GACCTTCCTA 
CATGTCTTCC ATCACTCTGT GCTTCCCTGG AGCTGGTGGT GGGGGGTAAA GATTGCCCCG 
GGAGGAATGG GCTCTTTCCA TGCCATGATA AACTCTTCCG TGCATGTCAT AATGTACCTG 
TACTACGGAT TATCTGCCTT TGGCCCTGTG GCACAACCCT ACCTTTGGTG GAAAAAGCAC 
ATGACAGCCA TTCAGCTGAT CCAGTTTGTC CTGGTCTCAC TGCACATCTC CCAGTACTAC 
TTTATGTCCA GCTGTAACTA CCAGTACCCA GTCATTATTC ACCTCATCTG GATGTATGGC 
ACCATCTTCT TCATGCTGTT CTCCAACTTC TGGTATCACT CTTATACCAA GGGCAAGCGG 
CTGCCCCGTG CACTTCAGCA AAATGGAGCT CCAGGTATTG CCAAGGTCAA GGCCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELOVL1 ( NM_001256399.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243328.1 Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13865
Clone ID Related Accession (Same CDS sequence)	NM_022821.3 , NM_022821.4 , NM_001256399.1
Accession Version	NM_001256399.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	elongation of very long chain fatty acids protein 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB149715.1, BP208926.1, BU857779.1, BC000618.2 and AA635780.1. Transcript Variant: This variant (2) uses a different 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: SRR1163655.273540.1, SRR1163657.27544.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGAGGCTG TTGTGAACTT GTACCAAGAG GTGATGAAGC ACGCAGATCC CCGGATCCAG 
GGCTACCCTC TGATGGGGTC CCCCTTGCTA ATGACCTCCA TTCTCCTGAC CTACGTGTAC 
TTCGTTCTCT CACTTGGGCC TCGCATCATG GCTAATCGGA AGCCCTTCCA GCTCCGTGGC 
TTCATGATTG TCTACAACTT CTCACTGGTG GCACTCTCCC TCTACATTGT CTATGAGTTC 
CTGATGTCGG GCTGGCTGAG CACCTATACC TGGCGCTGTG ACCCTGTGGA CTATTCCAAC 
AGCCCTGAGG CACTTAGGAT GGTTCGGGTG GCCTGGCTCT TCCTCTTCTC CAAGTTCATT 
GAGCTGATGG ACACAGTGAT CTTTATTCTC CGAAAGAAAG ACGGGCAGGT GACCTTCCTA 
CATGTCTTCC ATCACTCTGT GCTTCCCTGG AGCTGGTGGT GGGGGGTAAA GATTGCCCCG 
GGAGGAATGG GCTCTTTCCA TGCCATGATA AACTCTTCCG TGCATGTCAT AATGTACCTG 
TACTACGGAT TATCTGCCTT TGGCCCTGTG GCACAACCCT ACCTTTGGTG GAAAAAGCAC 
ATGACAGCCA TTCAGCTGAT CCAGTTTGTC CTGGTCTCAC TGCACATCTC CCAGTACTAC 
TTTATGTCCA GCTGTAACTA CCAGTACCCA GTCATTATTC ACCTCATCTG GATGTATGGC 
ACCATCTTCT TCATGCTGTT CTCCAACTTC TGGTATCACT CTTATACCAA GGGCAAGCGG 
CTGCCCCGTG CACTTCAGCA AAATGGAGCT CCAGGTATTG CCAAGGTCAA GGCCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243328.1
CDS	268..1107
Translation	MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN

Target ORF information:

RefSeq Version	NM_001256399.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256399.1

ORF Insert Sequence:

ATGGAGGCTG TTGTGAACTT GTACCAAGAG GTGATGAAGC ACGCAGATCC CCGGATCCAG 
GGCTACCCTC TGATGGGGTC CCCCTTGCTA ATGACCTCCA TTCTCCTGAC CTACGTGTAC 
TTCGTTCTCT CACTTGGGCC TCGCATCATG GCTAATCGGA AGCCCTTCCA GCTCCGTGGC 
TTCATGATTG TCTACAACTT CTCACTGGTG GCACTCTCCC TCTACATTGT CTATGAGTTC 
CTGATGTCGG GCTGGCTGAG CACCTATACC TGGCGCTGTG ACCCTGTGGA CTATTCCAAC 
AGCCCTGAGG CACTTAGGAT GGTTCGGGTG GCCTGGCTCT TCCTCTTCTC CAAGTTCATT 
GAGCTGATGG ACACAGTGAT CTTTATTCTC CGAAAGAAAG ACGGGCAGGT GACCTTCCTA 
CATGTCTTCC ATCACTCTGT GCTTCCCTGG AGCTGGTGGT GGGGGGTAAA GATTGCCCCG 
GGAGGAATGG GCTCTTTCCA TGCCATGATA AACTCTTCCG TGCATGTCAT AATGTACCTG 
TACTACGGAT TATCTGCCTT TGGCCCTGTG GCACAACCCT ACCTTTGGTG GAAAAAGCAC 
ATGACAGCCA TTCAGCTGAT CCAGTTTGTC CTGGTCTCAC TGCACATCTC CCAGTACTAC 
TTTATGTCCA GCTGTAACTA CCAGTACCCA GTCATTATTC ACCTCATCTG GATGTATGGC 
ACCATCTTCT TCATGCTGTT CTCCAACTTC TGGTATCACT CTTATACCAA GGGCAAGCGG 
CTGCCCCGTG CACTTCAGCA AAATGGAGCT CCAGGTATTG CCAAGGTCAA GGCCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELOVL1 ( NM_001256402.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243331.1 Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 4, mRNA.

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CloneID	OHu29168
Clone ID Related Accession (Same CDS sequence)	NM_001256402.1 , NM_001256402.2
Accession Version	NM_001256402.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1530201600000
Organism	Homo sapiens(human)
Product	elongation of very long chain fatty acids protein 1 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP281965.1, BM556982.1, BC000618.2 and AA635780.1. Transcript Variant: This variant (4) lacks an alternate exon which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: ERR279876.5781.1, SRR1163657.552663.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCGGGCT GGCTGAGCAC CTATACCTGG CGCTGTGACC CTGTGGACTA TTCCAACAGC 
CCTGAGGCAC TTAGGATGGT TCGGGTGGCC TGGCTCTTCC TCTTCTCCAA GTTCATTGAG 
CTGATGGACA CAGTGATCTT TATTCTCCGA AAGAAAGACG GGCAGGTGAC CTTCCTACAT 
GTCTTCCATC ACTCTGTGCT TCCCTGGAGC TGGTGGTGGG GGGTAAAGAT TGCCCCGGGA 
GGAATGGGCT CTTTCCATGC CATGATAAAC TCTTCCGTGC ATGTCATAAT GTACCTGTAC 
TACGGATTAT CTGCCTTTGG CCCTGTGGCA CAACCCTACC TTTGGTGGAA AAAGCACATG 
ACAGCCATTC AGCTGATCCA GTTTGTCCTG GTCTCACTGC ACATCTCCCA GTACTACTTT 
ATGTCCAGCT GTAACTACCA GTACCCAGTC ATTATTCACC TCATCTGGAT GTATGGCACC 
ATCTTCTTCA TGCTGTTCTC CAACTTCTGG TATCACTCTT ATACCAAGGG CAAGCGGCTG 
CCCCGTGCAC TTCAGCAAAA TGGAGCTCCA GGTATTGCCA AGGTCAAGGC CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243331.1
CDS	227..823
Translation	MSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN

Target ORF information:

RefSeq Version	NM_001256402.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256402.1

ORF Insert Sequence:

ATGTCGGGCT GGCTGAGCAC CTATACCTGG CGCTGTGACC CTGTGGACTA TTCCAACAGC 
CCTGAGGCAC TTAGGATGGT TCGGGTGGCC TGGCTCTTCC TCTTCTCCAA GTTCATTGAG 
CTGATGGACA CAGTGATCTT TATTCTCCGA AAGAAAGACG GGCAGGTGAC CTTCCTACAT 
GTCTTCCATC ACTCTGTGCT TCCCTGGAGC TGGTGGTGGG GGGTAAAGAT TGCCCCGGGA 
GGAATGGGCT CTTTCCATGC CATGATAAAC TCTTCCGTGC ATGTCATAAT GTACCTGTAC 
TACGGATTAT CTGCCTTTGG CCCTGTGGCA CAACCCTACC TTTGGTGGAA AAAGCACATG 
ACAGCCATTC AGCTGATCCA GTTTGTCCTG GTCTCACTGC ACATCTCCCA GTACTACTTT 
ATGTCCAGCT GTAACTACCA GTACCCAGTC ATTATTCACC TCATCTGGAT GTATGGCACC 
ATCTTCTTCA TGCTGTTCTC CAACTTCTGG TATCACTCTT ATACCAAGGG CAAGCGGCTG 
CCCCGTGCAC TTCAGCAAAA TGGAGCTCCA GGTATTGCCA AGGTCAAGGC CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELOVL1 ( NM_001256402.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243331.1 Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu29168
Clone ID Related Accession (Same CDS sequence)	NM_001256402.1 , NM_001256402.2
Accession Version	NM_001256402.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577721600000
Organism	Homo sapiens(human)
Product	elongation of very long chain fatty acids protein 1 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM556982.1, BC000618.2 and AA635780.1. On May 31, 2019 this sequence version replaced NM_001256402.1. Transcript Variant: This variant (4) lacks an alternate exon which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: ERR279876.5781.1, SRR7346977.325018.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCGGGCT GGCTGAGCAC CTATACCTGG CGCTGTGACC CTGTGGACTA TTCCAACAGC 
CCTGAGGCAC TTAGGATGGT TCGGGTGGCC TGGCTCTTCC TCTTCTCCAA GTTCATTGAG 
CTGATGGACA CAGTGATCTT TATTCTCCGA AAGAAAGACG GGCAGGTGAC CTTCCTACAT 
GTCTTCCATC ACTCTGTGCT TCCCTGGAGC TGGTGGTGGG GGGTAAAGAT TGCCCCGGGA 
GGAATGGGCT CTTTCCATGC CATGATAAAC TCTTCCGTGC ATGTCATAAT GTACCTGTAC 
TACGGATTAT CTGCCTTTGG CCCTGTGGCA CAACCCTACC TTTGGTGGAA AAAGCACATG 
ACAGCCATTC AGCTGATCCA GTTTGTCCTG GTCTCACTGC ACATCTCCCA GTACTACTTT 
ATGTCCAGCT GTAACTACCA GTACCCAGTC ATTATTCACC TCATCTGGAT GTATGGCACC 
ATCTTCTTCA TGCTGTTCTC CAACTTCTGG TATCACTCTT ATACCAAGGG CAAGCGGCTG 
CCCCGTGCAC TTCAGCAAAA TGGAGCTCCA GGTATTGCCA AGGTCAAGGC CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243331.1
CDS	164..760
Translation	MSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN

Target ORF information:

RefSeq Version	NM_001256402.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256402.2

ORF Insert Sequence:

ATGTCGGGCT GGCTGAGCAC CTATACCTGG CGCTGTGACC CTGTGGACTA TTCCAACAGC 
CCTGAGGCAC TTAGGATGGT TCGGGTGGCC TGGCTCTTCC TCTTCTCCAA GTTCATTGAG 
CTGATGGACA CAGTGATCTT TATTCTCCGA AAGAAAGACG GGCAGGTGAC CTTCCTACAT 
GTCTTCCATC ACTCTGTGCT TCCCTGGAGC TGGTGGTGGG GGGTAAAGAT TGCCCCGGGA 
GGAATGGGCT CTTTCCATGC CATGATAAAC TCTTCCGTGC ATGTCATAAT GTACCTGTAC 
TACGGATTAT CTGCCTTTGG CCCTGTGGCA CAACCCTACC TTTGGTGGAA AAAGCACATG 
ACAGCCATTC AGCTGATCCA GTTTGTCCTG GTCTCACTGC ACATCTCCCA GTACTACTTT 
ATGTCCAGCT GTAACTACCA GTACCCAGTC ATTATTCACC TCATCTGGAT GTATGGCACC 
ATCTTCTTCA TGCTGTTCTC CAACTTCTGG TATCACTCTT ATACCAAGGG CAAGCGGCTG 
CCCCGTGCAC TTCAGCAAAA TGGAGCTCCA GGTATTGCCA AGGTCAAGGC CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dominant
Journal of medical genetics55(6)408-414(2018 06)
Kutkowska-Kaźmierczak A,Rydzanicz M,Chlebowski A,Kłosowska-Kosicka K,Mika A,Gruchota J,Jurkiewicz E,Kowalewski C,Pollak A,Stradomska TJ,Kmieć T,Jakubowski R,Gasperowicz P,Walczak A,Śladowski D,Jankowska-Steifer E,Korniszewski L,Kosińska J,Obersztyn E,Nowak W,Śledziński T,Dziembowski A,Płoski R

Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis.
Biochimica et biophysica acta1851(2)231-7(2015 Feb)
Schackmann MJ,Ofman R,Dijkstra IM,Wanders RJ,Kemp S

Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid.
Journal of lipid research55(3)524-30(2014 Mar)
Sassa T,Wakashima T,Ohno Y,Kihara A

The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.
The international journal of biochemistry & cell biology45(7)1195-203(2013 Jul)
Hartmann D,Wegner MS,Wanger RA,Ferreirós N,Schreiber Y,Lucks J,Schiffmann S,Geisslinger G,Grösch S

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
Proceedings of the National Academy of Sciences of the United States of America107(43)18439-44(2010 Oct)
Ohno Y,Suto S,Yamanaka M,Mizutani Y,Mitsutake S,Igarashi Y,Sassa T,Kihara A

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ELOVL1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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