SFRP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SFRP4
Entrez Gene ID	6424
Full Name	secreted frizzled related protein 4
Synonyms	FRP-4,FRPHE,FRZB-2,PYL,sFRP-4
General protein information	Preferred Names secreted frizzled related protein 4 Names secreted frizzled-related protein 4 frizzled protein, human endometrium secreted frizzled-related protein 4; secreted frizzled-related protein 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.1
Summary	Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008].
Disorder MIM:	606570
Disorder Html:	Pyle disease, 265900 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003014.3	NP_003005.2	secreted frizzled-related protein 4 precursor
NM_003014.4	NP_003005.2	secreted frizzled-related protein 4 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SFRP4	XP_519048.3
Canis lupus familiaris (dog)	SFRP4	XP_540377.2
Gallus gallus (chicken)	SFRP4	XP_418831.4
Macaca mulatta (Rhesus monkey)	SFRP4	NP_001028134.1
Rattus norvegicus (Norway rat)	Sfrp4	NP_445996.1
Xenopus tropicalis (tropical clawed frog)	sfrp4	XP_002939467.2
Mus musculus (house mouse)	Sfrp4	NP_057896.1
Homo sapiens (human)	SFRP4	NP_003005.2
Bos taurus (cattle)	SFRP4	NP_001069232.1

Gene Ontology
Bibliography

Related articles in PubMed

Aberrant expression of the sFRP and WIF1 genes in invasive non-functioning pituitary adenomas.
Song W, Qian L, Jing G, Jie F, Xiaosong S, Chunhui L, Yangfang L, Guilin L, Gao H, Yazhuo Z
Molecular and cellular endocrinology474168-175(2018 10)

Increased secreted frizzled-related protein 4 and ficolin-3 levels in gestational diabetes mellitus women.
Yuan XS, Zhang M, Wang HY, Jiang J, Yu B
Endocrine journal65(4)499-508(2018 Apr)

The inhibitory influence of adipose tissue-derived mesenchymal stem cell environment and Wnt antagonism on breast tumour cell lines.
Visweswaran M, Arfuso F, Dilley RJ, Newsholme P, Dharmarajan A
The international journal of biochemistry & cell biology9563-72(2018 02)

Evaluation of fractalkine (FKN) and secreted frizzled-related protein 4 (SFRP-4) serum levels in patients with prediabetes and type 2 diabetes.
Baldane S, Ipekci SH, Ekin A, Abusoglu S, Unlu A, Kebapcilar L
Bratislavske lekarske listy119(2)112-115(2018)

High-order gene interactions between the genetic polymorphisms in Wnt and AhR pathway in modulating lung cancer susceptibility.
Bahl C, Singh N, Behera D, Sharma S
Personalized medicine14(6)487-502(2017 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SFRP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SFRP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08954	NM_003014.4 Latest version!	Homo sapiens secreted frizzled related protein 4 (SFRP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu08954	NM_003014.3	Homo sapiens secreted frizzled related protein 4 (SFRP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SFRP4 ( NM_003014.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003005.2 Homo sapiens secreted frizzled related protein 4 (SFRP4), mRNA.

Price & Availability↑

CloneID	OHu08954
Clone ID Related Accession (Same CDS sequence)	NM_003014.3 , NM_003014.4
Accession Version	NM_003014.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1508860800000
Organism	Homo sapiens(human)
Product	secreted frizzled-related protein 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018634.3 and BT019679.1. This sequence is a reference standard in the RefSeqGene project. On Mar 26, 2008 this sequence version replaced NM_003014.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.178948.1, SRR1803617.248965.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCCTCT CCATCCTAGT GGCGCTGTGC CTGTGGCTGC ACCTGGCGCT GGGCGTGCGC 
GGCGCGCCCT GCGAGGCGGT GCGCATCCCT ATGTGCCGGC ACATGCCCTG GAACATCACG 
CGGATGCCCA ACCACCTGCA CCACAGCACG CAGGAGAACG CCATCCTGGC CATCGAGCAG 
TACGAGGAGC TGGTGGACGT GAACTGCAGC GCCGTGCTGC GCTTCTTCCT CTGTGCCATG 
TACGCGCCCA TTTGCACCCT GGAGTTCCTG CACGACCCTA TCAAGCCGTG CAAGTCGGTG 
TGCCAACGCG CGCGCGACGA CTGCGAGCCC CTCATGAAGA TGTACAACCA CAGCTGGCCC 
GAAAGCCTGG CCTGCGACGA GCTGCCTGTC TATGACCGTG GCGTGTGCAT CTCGCCTGAA 
GCCATCGTCA CGGACCTCCC GGAGGATGTT AAGTGGATAG ACATCACACC AGACATGATG 
GTACAGGAAA GGCCTCTTGA TGTTGACTGT AAACGCCTAA GCCCCGATCG GTGCAAGTGT 
AAAAAGGTGA AGCCAACTTT GGCAACGTAT CTCAGCAAAA ACTACAGCTA TGTTATTCAT 
GCCAAAATAA AAGCTGTGCA GAGGAGTGGC TGCAATGAGG TCACAACGGT GGTGGATGTA 
AAAGAGATCT TCAAGTCCTC ATCACCCATC CCTCGAACTC AAGTCCCGCT CATTACAAAT 
TCTTCTTGCC AGTGTCCACA CATCCTGCCC CATCAAGATG TTCTCATCAT GTGTTACGAG 
TGGCGCTCAA GGATGATGCT TCTTGAAAAT TGCTTAGTTG AAAAATGGAG AGATCAGCTT 
AGTAAAAGAT CCATACAGTG GGAAGAGAGG CTGCAGGAAC AGCGGAGAAC AGTTCAGGAC 
AAGAAGAAAA CAGCCGGGCG CACCAGTCGT AGTAATCCCC CCAAACCAAA GGGAAAGCCT 
CCTGCTCCCA AACCAGCCAG TCCCAAGAAG AACATTAAAA CTAGGAGTGC CCAGAAGAGA 
ACAAACCCGA AAAGAGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003005.2
CDS	387..1427
Translation	MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSSSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPPAPKPASPKKNIKTRSAQKRTNPKRV

Target ORF information:

RefSeq Version	NM_003014.3
Organism	Homo sapiens(human)
Definition	Homo sapiens secreted frizzled related protein 4 (SFRP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003014.3

ORF Insert Sequence:

ATGTTCCTCT CCATCCTAGT GGCGCTGTGC CTGTGGCTGC ACCTGGCGCT GGGCGTGCGC 
GGCGCGCCCT GCGAGGCGGT GCGCATCCCT ATGTGCCGGC ACATGCCCTG GAACATCACG 
CGGATGCCCA ACCACCTGCA CCACAGCACG CAGGAGAACG CCATCCTGGC CATCGAGCAG 
TACGAGGAGC TGGTGGACGT GAACTGCAGC GCCGTGCTGC GCTTCTTCCT CTGTGCCATG 
TACGCGCCCA TTTGCACCCT GGAGTTCCTG CACGACCCTA TCAAGCCGTG CAAGTCGGTG 
TGCCAACGCG CGCGCGACGA CTGCGAGCCC CTCATGAAGA TGTACAACCA CAGCTGGCCC 
GAAAGCCTGG CCTGCGACGA GCTGCCTGTC TATGACCGTG GCGTGTGCAT CTCGCCTGAA 
GCCATCGTCA CGGACCTCCC GGAGGATGTT AAGTGGATAG ACATCACACC AGACATGATG 
GTACAGGAAA GGCCTCTTGA TGTTGACTGT AAACGCCTAA GCCCCGATCG GTGCAAGTGT 
AAAAAGGTGA AGCCAACTTT GGCAACGTAT CTCAGCAAAA ACTACAGCTA TGTTATTCAT 
GCCAAAATAA AAGCTGTGCA GAGGAGTGGC TGCAATGAGG TCACAACGGT GGTGGATGTA 
AAAGAGATCT TCAAGTCCTC ATCACCCATC CCTCGAACTC AAGTCCCGCT CATTACAAAT 
TCTTCTTGCC AGTGTCCACA CATCCTGCCC CATCAAGATG TTCTCATCAT GTGTTACGAG 
TGGCGCTCAA GGATGATGCT TCTTGAAAAT TGCTTAGTTG AAAAATGGAG AGATCAGCTT 
AGTAAAAGAT CCATACAGTG GGAAGAGAGG CTGCAGGAAC AGCGGAGAAC AGTTCAGGAC 
AAGAAGAAAA CAGCCGGGCG CACCAGTCGT AGTAATCCCC CCAAACCAAA GGGAAAGCCT 
CCTGCTCCCA AACCAGCCAG TCCCAAGAAG AACATTAAAA CTAGGAGTGC CCAGAAGAGA 
ACAAACCCGA AAAGAGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SFRP4 ( NM_003014.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003005.2 Homo sapiens secreted frizzled related protein 4 (SFRP4), mRNA.

Price & Availability↑

CloneID	OHu08954
Clone ID Related Accession (Same CDS sequence)	NM_003014.3 , NM_003014.4
Accession Version	NM_003014.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573833600000
Organism	Homo sapiens(human)
Product	secreted frizzled-related protein 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018634.3 and BT019679.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003014.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.46119.1, SRR1803614.178948.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal MANE Ensembl match :: ENST00000436072.7/ ENSP00000410715.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTCCTCT CCATCCTAGT GGCGCTGTGC CTGTGGCTGC ACCTGGCGCT GGGCGTGCGC 
GGCGCGCCCT GCGAGGCGGT GCGCATCCCT ATGTGCCGGC ACATGCCCTG GAACATCACG 
CGGATGCCCA ACCACCTGCA CCACAGCACG CAGGAGAACG CCATCCTGGC CATCGAGCAG 
TACGAGGAGC TGGTGGACGT GAACTGCAGC GCCGTGCTGC GCTTCTTCCT CTGTGCCATG 
TACGCGCCCA TTTGCACCCT GGAGTTCCTG CACGACCCTA TCAAGCCGTG CAAGTCGGTG 
TGCCAACGCG CGCGCGACGA CTGCGAGCCC CTCATGAAGA TGTACAACCA CAGCTGGCCC 
GAAAGCCTGG CCTGCGACGA GCTGCCTGTC TATGACCGTG GCGTGTGCAT CTCGCCTGAA 
GCCATCGTCA CGGACCTCCC GGAGGATGTT AAGTGGATAG ACATCACACC AGACATGATG 
GTACAGGAAA GGCCTCTTGA TGTTGACTGT AAACGCCTAA GCCCCGATCG GTGCAAGTGT 
AAAAAGGTGA AGCCAACTTT GGCAACGTAT CTCAGCAAAA ACTACAGCTA TGTTATTCAT 
GCCAAAATAA AAGCTGTGCA GAGGAGTGGC TGCAATGAGG TCACAACGGT GGTGGATGTA 
AAAGAGATCT TCAAGTCCTC ATCACCCATC CCTCGAACTC AAGTCCCGCT CATTACAAAT 
TCTTCTTGCC AGTGTCCACA CATCCTGCCC CATCAAGATG TTCTCATCAT GTGTTACGAG 
TGGCGCTCAA GGATGATGCT TCTTGAAAAT TGCTTAGTTG AAAAATGGAG AGATCAGCTT 
AGTAAAAGAT CCATACAGTG GGAAGAGAGG CTGCAGGAAC AGCGGAGAAC AGTTCAGGAC 
AAGAAGAAAA CAGCCGGGCG CACCAGTCGT AGTAATCCCC CCAAACCAAA GGGAAAGCCT 
CCTGCTCCCA AACCAGCCAG TCCCAAGAAG AACATTAAAA CTAGGAGTGC CCAGAAGAGA 
ACAAACCCGA AAAGAGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003005.2
CDS	281..1321
Translation	MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSSSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPPAPKPASPKKNIKTRSAQKRTNPKRV

Target ORF information:

RefSeq Version	NM_003014.4
Organism	Homo sapiens(human)
Definition	Homo sapiens secreted frizzled related protein 4 (SFRP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003014.4

ORF Insert Sequence:

ATGTTCCTCT CCATCCTAGT GGCGCTGTGC CTGTGGCTGC ACCTGGCGCT GGGCGTGCGC 
GGCGCGCCCT GCGAGGCGGT GCGCATCCCT ATGTGCCGGC ACATGCCCTG GAACATCACG 
CGGATGCCCA ACCACCTGCA CCACAGCACG CAGGAGAACG CCATCCTGGC CATCGAGCAG 
TACGAGGAGC TGGTGGACGT GAACTGCAGC GCCGTGCTGC GCTTCTTCCT CTGTGCCATG 
TACGCGCCCA TTTGCACCCT GGAGTTCCTG CACGACCCTA TCAAGCCGTG CAAGTCGGTG 
TGCCAACGCG CGCGCGACGA CTGCGAGCCC CTCATGAAGA TGTACAACCA CAGCTGGCCC 
GAAAGCCTGG CCTGCGACGA GCTGCCTGTC TATGACCGTG GCGTGTGCAT CTCGCCTGAA 
GCCATCGTCA CGGACCTCCC GGAGGATGTT AAGTGGATAG ACATCACACC AGACATGATG 
GTACAGGAAA GGCCTCTTGA TGTTGACTGT AAACGCCTAA GCCCCGATCG GTGCAAGTGT 
AAAAAGGTGA AGCCAACTTT GGCAACGTAT CTCAGCAAAA ACTACAGCTA TGTTATTCAT 
GCCAAAATAA AAGCTGTGCA GAGGAGTGGC TGCAATGAGG TCACAACGGT GGTGGATGTA 
AAAGAGATCT TCAAGTCCTC ATCACCCATC CCTCGAACTC AAGTCCCGCT CATTACAAAT 
TCTTCTTGCC AGTGTCCACA CATCCTGCCC CATCAAGATG TTCTCATCAT GTGTTACGAG 
TGGCGCTCAA GGATGATGCT TCTTGAAAAT TGCTTAGTTG AAAAATGGAG AGATCAGCTT 
AGTAAAAGAT CCATACAGTG GGAAGAGAGG CTGCAGGAAC AGCGGAGAAC AGTTCAGGAC 
AAGAAGAAAA CAGCCGGGCG CACCAGTCGT AGTAATCCCC CCAAACCAAA GGGAAAGCCT 
CCTGCTCCCA AACCAGCCAG TCCCAAGAAG AACATTAAAA CTAGGAGTGC CCAGAAGAGA 
ACAAACCCGA AAAGAGTGTG A