MAPK12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAPK12
Entrez Gene ID	6300
Full Name	mitogen-activated protein kinase 12
Synonyms	ERK-6,ERK3,ERK6,MAPK 12,P38GAMMA,PRKM12,SAPK-3,SAPK3
General protein information	Preferred Names mitogen-activated protein kinase 12 Names mitogen-activated protein kinase 12 MAP kinase 12 MAP kinase p38 gamma extracellular signal-regulated kinase 6 mitogen-activated protein kinase 3 mitogen-activated protein kinase p38 gamma stress-activated protein kinase 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.33
Summary	Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008].
Disorder MIM:	602399

mRNA and Protein(s)

mRNA	Protein	Name
NM_001303252.2	NP_001290181.1	mitogen-activated protein kinase 12 isoform 2
NM_002969.6	NP_002960.2	mitogen-activated protein kinase 12 isoform 1
NM_002969.5	NP_002960.2	mitogen-activated protein kinase 12 isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MAPK12	NP_001092423.1
Mus musculus (house mouse)	Mapk12	NP_038899.1
Gallus gallus (chicken)	MAPK12	XP_001233062.2
Homo sapiens (human)	MAPK12	NP_002960.2
Macaca mulatta (Rhesus monkey)	MAPK12	XP_001112462.1
Danio rerio (zebrafish)	mapk12b	NP_001038306.1
Xenopus tropicalis (tropical clawed frog)	mapk12	NP_001017080.1
Pan troglodytes (chimpanzee)	MAPK12	XP_001155820.3
Canis lupus familiaris (dog)	MAPK12	XP_848658.2
Rattus norvegicus (Norway rat)	Mapk12	NP_068514.1
Danio rerio (zebrafish)	mapk12a	NP_571482.1

Gene Ontology
Bibliography

Related articles in PubMed

p38γ is essential for cell cycle progression and liver tumorigenesis.
Tomás-Loba A, Manieri E, González-Terán B, Mora A, Leiva-Vega L, Santamans AM, Romero-Becerra R, Rodríguez E, Pintor-Chocano A, Feixas F, López JA, Caballero B, Trakala M, Blanco Ó, Torres JL, Hernández-Cosido L, Montalvo-Romeral V, Matesanz N, Roche-Molina M, Bernal JA, Mischo H, León M, Caballero A, Miranda-Saavedra D, Ruiz-Cabello J, Nevzorova YA, Cubero FJ, Bravo J, Vázquez J, Malumbres M, Marcos M, Osuna S, Sabio G
Nature568(7753)557-560(2019 04)

Impact of p38γ mitogen-activated protein kinase (MAPK) on MDA-MB-231 breast cancer cells using metabolomic approach.
Chen H, Wang X, Guo F, Li P, Peng D, He J
The international journal of biochemistry & cell biology1076-13(2019 02)

Role of p38γ MAPK in regulation of EMT and cancer stem cells.
Xu M, Wang S, Wang Y, Wu H, Frank JA, Zhang Z, Luo J
Biochimica et biophysica acta. Molecular basis of disease1864(11)3605-3617(2018 11)

IFN-γ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5.
Saleiro D, Blyth GT, Kosciuczuk EM, Ozark PA, Majchrzak-Kita B, Arslan AD, Fischietti M, Reddy NK, Horvath CM, Davis RJ, Fish EN, Platanias LC
Science signaling11(557)(2018 11)

Activation loop phosphorylation of ERK3 is important for its kinase activity and ability to promote lung cancer cell invasiveness.
Elkhadragy L, Alsaran H, Morel M, Long W
The Journal of biological chemistry293(42)16193-16205(2018 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAPK12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAPK12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu60358	NM_002969.6 Latest version!	Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$300.30 $429.00
OHu60359	NM_001303252.2 Latest version!	Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$258.30 $369.00
View Old Accession Versions >>
OHu60358	NM_002969.5	Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$300.30 $429.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAPK12 ( NM_002969.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_002960.2 Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu60358
Clone ID Related Accession (Same CDS sequence)	NM_002969.6 , NM_002969.5
Accession Version	NM_002969.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase 12 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U66243.2, CB123561.1, Y10487.1, BC015741.1 and N94360.1. On Nov 22, 2018 this sequence version replaced NM_002969.5. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y10487.1, SRR1163655.92310.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000215659.13/ ENSP00000215659.8 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTCTC CGCCGCCCGC CCGCAGTGGC TTTTACCGCC AGGAGGTGAC CAAGACGGCC 
TGGGAGGTGC GCGCCGTGTA CCGGGACCTG CAGCCCGTGG GCTCGGGCGC CTACGGCGCG 
GTGTGCTCGG CCGTGGACGG CCGCACCGGC GCTAAGGTGG CCATCAAGAA GCTGTATCGG 
CCTTTCCAGT CCGAGCTGTT CGCCAAGCGC GCCTACCGCG AGCTGCGCCT GCTCAAGCAC 
ATGCGCCACG AGAACGTGAT CGGGCTGCTG GACGTATTCA CTCCTGATGA GACCCTGGAT 
GACTTCACGG ACTTTTACCT GGTGATGCCG TTCATGGGCA CCGACCTGGG CAAGCTCATG 
AAACATGAGA AGCTAGGCGA GGACCGGATC CAGTTCCTCG TGTACCAGAT GCTGAAGGGG 
CTGAGGTATA TCCACGCTGC CGGCATCATC CACAGAGACC TGAAGCCCGG CAACCTGGCT 
GTGAACGAAG ACTGTGAGCT GAAGATCCTG GACTTCGGCC TGGCCAGGCA GGCAGACAGT 
GAGATGACTG GGTACGTGGT GACCCGGTGG TACCGGGCTC CCGAGGTCAT CTTGAATTGG 
ATGCGCTACA CGCAGACGGT GGACATCTGG TCTGTGGGCT GCATCATGGC GGAGATGATC 
ACAGGCAAGA CGCTGTTCAA GGGCAGCGAC CACCTGGACC AGCTGAAGGA GATCATGAAG 
GTGACGGGGA CGCCTCCGGC TGAGTTTGTG CAGCGGCTGC AGAGCGATGA GGCCAAGAAC 
TACATGAAGG GCCTCCCCGA ATTGGAGAAG AAGGATTTTG CCTCTATCCT GACCAATGCA 
AGCCCTCTGG CTGTGAACCT CCTGGAGAAG ATGCTGGTGC TGGACGCGGA GCAGCGGGTG 
ACGGCAGGCG AGGCGCTGGC CCATCCCTAC TTCGAGTCCC TGCACGACAC GGAAGATGAG 
CCCCAGGTCC AGAAGTATGA TGACTCCTTT GACGACGTTG ACCGCACACT GGATGAATGG 
AAGCGTGTTA CTTACAAAGA GGTGCTCAGC TTCAAGCCTC CCCGGCAGCT GGGGGCCAGG 
GTCTCCAAGG AGACGCCTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002960.2
CDS	175..1278
Translation	MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL

Target ORF information:

RefSeq Version	NM_002969.6
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002969.6

ORF Insert Sequence:

ATGAGCTCTC CGCCGCCCGC CCGCAGTGGC TTTTACCGCC AGGAGGTGAC CAAGACGGCC 
TGGGAGGTGC GCGCCGTGTA CCGGGACCTG CAGCCCGTGG GCTCGGGCGC CTACGGCGCG 
GTGTGCTCGG CCGTGGACGG CCGCACCGGC GCTAAGGTGG CCATCAAGAA GCTGTATCGG 
CCTTTCCAGT CCGAGCTGTT CGCCAAGCGC GCCTACCGCG AGCTGCGCCT GCTCAAGCAC 
ATGCGCCACG AGAACGTGAT CGGGCTGCTG GACGTATTCA CTCCTGATGA GACCCTGGAT 
GACTTCACGG ACTTTTACCT GGTGATGCCG TTCATGGGCA CCGACCTGGG CAAGCTCATG 
AAACATGAGA AGCTAGGCGA GGACCGGATC CAGTTCCTCG TGTACCAGAT GCTGAAGGGG 
CTGAGGTATA TCCACGCTGC CGGCATCATC CACAGAGACC TGAAGCCCGG CAACCTGGCT 
GTGAACGAAG ACTGTGAGCT GAAGATCCTG GACTTCGGCC TGGCCAGGCA GGCAGACAGT 
GAGATGACTG GGTACGTGGT GACCCGGTGG TACCGGGCTC CCGAGGTCAT CTTGAATTGG 
ATGCGCTACA CGCAGACGGT GGACATCTGG TCTGTGGGCT GCATCATGGC GGAGATGATC 
ACAGGCAAGA CGCTGTTCAA GGGCAGCGAC CACCTGGACC AGCTGAAGGA GATCATGAAG 
GTGACGGGGA CGCCTCCGGC TGAGTTTGTG CAGCGGCTGC AGAGCGATGA GGCCAAGAAC 
TACATGAAGG GCCTCCCCGA ATTGGAGAAG AAGGATTTTG CCTCTATCCT GACCAATGCA 
AGCCCTCTGG CTGTGAACCT CCTGGAGAAG ATGCTGGTGC TGGACGCGGA GCAGCGGGTG 
ACGGCAGGCG AGGCGCTGGC CCATCCCTAC TTCGAGTCCC TGCACGACAC GGAAGATGAG 
CCCCAGGTCC AGAAGTATGA TGACTCCTTT GACGACGTTG ACCGCACACT GGATGAATGG 
AAGCGTGTTA CTTACAAAGA GGTGCTCAGC TTCAAGCCTC CCCGGCAGCT GGGGGCCAGG 
GTCTCCAAGG AGACGCCTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAPK12 ( NM_002969.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002960.2 Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu60358
Clone ID Related Accession (Same CDS sequence)	NM_002969.6 , NM_002969.5
Accession Version	NM_002969.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1504886400000
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase 12 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U66243.2, CB123561.1, Y10487.1, BC015741.1 and N94360.1. On Dec 14, 2016 this sequence version replaced NM_002969.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U66243.2, Y10487.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCTC CGCCGCCCGC CCGCAGTGGC TTTTACCGCC AGGAGGTGAC CAAGACGGCC 
TGGGAGGTGC GCGCCGTGTA CCGGGACCTG CAGCCCGTGG GCTCGGGCGC CTACGGCGCG 
GTGTGCTCGG CCGTGGACGG CCGCACCGGC GCTAAGGTGG CCATCAAGAA GCTGTATCGG 
CCTTTCCAGT CCGAGCTGTT CGCCAAGCGC GCCTACCGCG AGCTGCGCCT GCTCAAGCAC 
ATGCGCCACG AGAACGTGAT CGGGCTGCTG GACGTATTCA CTCCTGATGA GACCCTGGAT 
GACTTCACGG ACTTTTACCT GGTGATGCCG TTCATGGGCA CCGACCTGGG CAAGCTCATG 
AAACATGAGA AGCTAGGCGA GGACCGGATC CAGTTCCTCG TGTACCAGAT GCTGAAGGGG 
CTGAGGTATA TCCACGCTGC CGGCATCATC CACAGAGACC TGAAGCCCGG CAACCTGGCT 
GTGAACGAAG ACTGTGAGCT GAAGATCCTG GACTTCGGCC TGGCCAGGCA GGCAGACAGT 
GAGATGACTG GGTACGTGGT GACCCGGTGG TACCGGGCTC CCGAGGTCAT CTTGAATTGG 
ATGCGCTACA CGCAGACGGT GGACATCTGG TCTGTGGGCT GCATCATGGC GGAGATGATC 
ACAGGCAAGA CGCTGTTCAA GGGCAGCGAC CACCTGGACC AGCTGAAGGA GATCATGAAG 
GTGACGGGGA CGCCTCCGGC TGAGTTTGTG CAGCGGCTGC AGAGCGATGA GGCCAAGAAC 
TACATGAAGG GCCTCCCCGA ATTGGAGAAG AAGGATTTTG CCTCTATCCT GACCAATGCA 
AGCCCTCTGG CTGTGAACCT CCTGGAGAAG ATGCTGGTGC TGGACGCGGA GCAGCGGGTG 
ACGGCAGGCG AGGCGCTGGC CCATCCCTAC TTCGAGTCCC TGCACGACAC GGAAGATGAG 
CCCCAGGTCC AGAAGTATGA TGACTCCTTT GACGACGTTG ACCGCACACT GGATGAATGG 
AAGCGTGTTA CTTACAAAGA GGTGCTCAGC TTCAAGCCTC CCCGGCAGCT GGGGGCCAGG 
GTCTCCAAGG AGACGCCTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002960.2
CDS	302..1405
Translation	MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL

Target ORF information:

RefSeq Version	NM_002969.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002969.5

ORF Insert Sequence:

ATGAGCTCTC CGCCGCCCGC CCGCAGTGGC TTTTACCGCC AGGAGGTGAC CAAGACGGCC 
TGGGAGGTGC GCGCCGTGTA CCGGGACCTG CAGCCCGTGG GCTCGGGCGC CTACGGCGCG 
GTGTGCTCGG CCGTGGACGG CCGCACCGGC GCTAAGGTGG CCATCAAGAA GCTGTATCGG 
CCTTTCCAGT CCGAGCTGTT CGCCAAGCGC GCCTACCGCG AGCTGCGCCT GCTCAAGCAC 
ATGCGCCACG AGAACGTGAT CGGGCTGCTG GACGTATTCA CTCCTGATGA GACCCTGGAT 
GACTTCACGG ACTTTTACCT GGTGATGCCG TTCATGGGCA CCGACCTGGG CAAGCTCATG 
AAACATGAGA AGCTAGGCGA GGACCGGATC CAGTTCCTCG TGTACCAGAT GCTGAAGGGG 
CTGAGGTATA TCCACGCTGC CGGCATCATC CACAGAGACC TGAAGCCCGG CAACCTGGCT 
GTGAACGAAG ACTGTGAGCT GAAGATCCTG GACTTCGGCC TGGCCAGGCA GGCAGACAGT 
GAGATGACTG GGTACGTGGT GACCCGGTGG TACCGGGCTC CCGAGGTCAT CTTGAATTGG 
ATGCGCTACA CGCAGACGGT GGACATCTGG TCTGTGGGCT GCATCATGGC GGAGATGATC 
ACAGGCAAGA CGCTGTTCAA GGGCAGCGAC CACCTGGACC AGCTGAAGGA GATCATGAAG 
GTGACGGGGA CGCCTCCGGC TGAGTTTGTG CAGCGGCTGC AGAGCGATGA GGCCAAGAAC 
TACATGAAGG GCCTCCCCGA ATTGGAGAAG AAGGATTTTG CCTCTATCCT GACCAATGCA 
AGCCCTCTGG CTGTGAACCT CCTGGAGAAG ATGCTGGTGC TGGACGCGGA GCAGCGGGTG 
ACGGCAGGCG AGGCGCTGGC CCATCCCTAC TTCGAGTCCC TGCACGACAC GGAAGATGAG 
CCCCAGGTCC AGAAGTATGA TGACTCCTTT GACGACGTTG ACCGCACACT GGATGAATGG 
AAGCGTGTTA CTTACAAAGA GGTGCTCAGC TTCAAGCCTC CCCGGCAGCT GGGGGCCAGG 
GTCTCCAAGG AGACGCCTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAPK12 ( NM_001303252.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290181.1 Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu60359
Clone ID Related Accession (Same CDS sequence)	NM_001303252.2
Accession Version	NM_001303252.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577548800000
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase 12 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U66243.2, CB123561.1, BX640648.1, Y10487.1, BC015741.1 and N94360.1. On Dec 14, 2016 this sequence version replaced NM_001303252.1. Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. This difference results in a shorter isoform (2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.230720.1, CR456515.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCTC CGCCGCCCGC CCGCAGTGGC TTTTACCGCC AGGAGGTGAC CAAGACGGCC 
TGGGAGGTGC GCGCCGTGTA CCGGGACCTG CAGCCCGTGG GCTCGGGCGC CTACGGCGCG 
GTGTGCTCGG CCGTGGACGG CCGCACCGGC GCTAAGGTGG CCATCAAGAA GCTGTATCGG 
CCTTTCCAGT CCGAGCTGTT CGCCAAGCGC GCCTACCGCG AGCTGCGCCT GCTCAAGCAC 
ATGCGCCACG AGAACGTGAT CGGGCTGCTG GACGTATTCA CTCCTGATGA GACCCTGGAT 
GACTTCACGG ACTTTTACCT GGTGATGCCG TTCATGGGCA CCGACCTGGG CAAGCTCATG 
AAACATGAGA AGCTAGGCGA GGACCGGATC CAGTTCCTCG TGTACCAGAT GCTGAAGGGG 
CTGAGGGACC TGAAGCCCGG CAACCTGGCT GTGAACGAAG ACTGTGAGCT GAAGATCCTG 
GACTTCGGCC TGGCCAGGCA GGCAGACAGT GAGATGACTG GGTACGTGGT GACCCGGTGG 
TACCGGGCTC CCGAGGTCAT CTTGAATTGG ATGCGCTACA CGCAGACGGT GGACATCTGG 
TCTGTGGGCT GCATCATGGC GGAGATGATC ACAGGCAAGA CGCTGTTCAA GGGCAGCGAC 
CACCTGGACC AGCTGAAGGA GATCATGAAG GTGACGGGGA CGCCTCCGGC TGAGTTTGTG 
CAGCGGCTGC AGAGCGATGA GGCCAAGAAC TACATGAAGG GCCTCCCCGA ATTGGAGAAG 
AAGGATTTTG CCTCTATCCT GACCAATGCA AGCCCTCTGG CTGTGAACCT CCTGGAGAAG 
ATGCTGGTGC TGGACGCGGA GCAGCGGGTG ACGGCAGGCG AGGCGCTGGC CCATCCCTAC 
TTCGAGTCCC TGCACGACAC GGAAGATGAG CCCCAGGTCC AGAAGTATGA TGACTCCTTT 
GACGACGTTG ACCGCACACT GGATGAATGG AAGCGTGTTA CTTACAAAGA GGTGCTCAGC 
TTCAAGCCTC CCCGGCAGCT GGGGGCCAGG GTCTCCAAGG AGACGCCTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290181.1
CDS	302..1375
Translation	MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL

Target ORF information:

RefSeq Version	NM_001303252.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303252.2

ORF Insert Sequence:

ATGAGCTCTC CGCCGCCCGC CCGCAGTGGC TTTTACCGCC AGGAGGTGAC CAAGACGGCC 
TGGGAGGTGC GCGCCGTGTA CCGGGACCTG CAGCCCGTGG GCTCGGGCGC CTACGGCGCG 
GTGTGCTCGG CCGTGGACGG CCGCACCGGC GCTAAGGTGG CCATCAAGAA GCTGTATCGG 
CCTTTCCAGT CCGAGCTGTT CGCCAAGCGC GCCTACCGCG AGCTGCGCCT GCTCAAGCAC 
ATGCGCCACG AGAACGTGAT CGGGCTGCTG GACGTATTCA CTCCTGATGA GACCCTGGAT 
GACTTCACGG ACTTTTACCT GGTGATGCCG TTCATGGGCA CCGACCTGGG CAAGCTCATG 
AAACATGAGA AGCTAGGCGA GGACCGGATC CAGTTCCTCG TGTACCAGAT GCTGAAGGGG 
CTGAGGGACC TGAAGCCCGG CAACCTGGCT GTGAACGAAG ACTGTGAGCT GAAGATCCTG 
GACTTCGGCC TGGCCAGGCA GGCAGACAGT GAGATGACTG GGTACGTGGT GACCCGGTGG 
TACCGGGCTC CCGAGGTCAT CTTGAATTGG ATGCGCTACA CGCAGACGGT GGACATCTGG 
TCTGTGGGCT GCATCATGGC GGAGATGATC ACAGGCAAGA CGCTGTTCAA GGGCAGCGAC 
CACCTGGACC AGCTGAAGGA GATCATGAAG GTGACGGGGA CGCCTCCGGC TGAGTTTGTG 
CAGCGGCTGC AGAGCGATGA GGCCAAGAAC TACATGAAGG GCCTCCCCGA ATTGGAGAAG 
AAGGATTTTG CCTCTATCCT GACCAATGCA AGCCCTCTGG CTGTGAACCT CCTGGAGAAG 
ATGCTGGTGC TGGACGCGGA GCAGCGGGTG ACGGCAGGCG AGGCGCTGGC CCATCCCTAC 
TTCGAGTCCC TGCACGACAC GGAAGATGAG CCCCAGGTCC AGAAGTATGA TGACTCCTTT 
GACGACGTTG ACCGCACACT GGATGAATGG AAGCGTGTTA CTTACAAAGA GGTGCTCAGC 
TTCAAGCCTC CCCGGCAGCT GGGGGCCAGG GTCTCCAAGG AGACGCCTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

p38γ is essential for cell cycle progression and liver tumorigenesis.
Nature568(7753)557-560(2019 04)
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