RIC8A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RIC8A
Entrez Gene ID	60626
Full Name	RIC8 guanine nucleotide exchange factor A
Synonyms	RIC8
General protein information	Preferred Names RIC8 guanine nucleotide exchange factor A Names synembryn-A resistance to inhibitors of cholinesterase 8 homolog A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.5
Disorder MIM:	609146

mRNA and Protein(s)

mRNA	Protein	Name
XM_017018107.2	XP_016873596.1	synembryn-A isoform X2
XM_017018107.1	XP_016873596.1	synembryn-A isoform X2
XM_005253052.4	XP_005253109.1	synembryn-A isoform X1
NM_001286134.1	NP_001273063.1	synembryn-A isoform 2
XM_005253052.3	XP_005253109.1	synembryn-A isoform X1
NM_021932.5	NP_068751.4	synembryn-A isoform 1

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010793	XP_318515.3
Homo sapiens (human)	RIC8A	NP_001273063.1
Rattus norvegicus (Norway rat)	Ric8a	NP_001093990.1
Canis lupus familiaris (dog)	RIC8A	XP_005631129.1
Mus musculus (house mouse)	Ric8	NP_444424.1
Macaca mulatta (Rhesus monkey)	RIC8A	XP_001083119.2
Bos taurus (cattle)	RIC8A	NP_001015627.1
Danio rerio (zebrafish)	ric8a	NP_001005588.1
Pan troglodytes (chimpanzee)	RIC8A	XP_521700.2
Drosophila melanogaster (fruit fly)	ric8a	NP_572550.2
Xenopus tropicalis (tropical clawed frog)	ric8a	NP_989159.1
Gallus gallus (chicken)	RIC8A	NP_001026345.1

Gene Ontology
Bibliography

Related articles in PubMed

Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange.
Papasergi-Scott MM, Stoveken HM, MacConnachie L, Chan PY, Gabay M, Wong D, Freeman RS, Beg AA, Tall GG
Science signaling11(532)(2018 05)

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα(i3).
Tse MK, Morris CJ, Zhang M, Wong YH
Molecular and cellular biochemistry401(1-2)27-38(2015 Mar)

The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release.
Romero-Pozuelo J, Dason JS, Mansilla A, Baños-Mateos S, Sardina JL, Chaves-Sanjuán A, Jurado-Gómez J, Santana E, Atwood HL, Hernández-Hernández Á, Sánchez-Barrena MJ, Ferrús A
Journal of cell science127(Pt 19)4246-59(2014 Oct)

Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity.
Boularan C, Kamenyeva O, Cho H, Kehrl JH
PloS one9(1)e86680(2014)

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
Shameer K, Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, Peissig P, Pacheco JA, Li R, Bastarache L, Kho AN, Ritchie MD, Masys DR, Chisholm RL, Larson EB, McCarty CA, Roden DM, Jarvik GP, Kullo IJ
Human genetics133(1)95-109(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RIC8A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RIC8A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu92418	XM_017018107.2 Latest version!	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu14387	NM_001286134.1 Latest version!	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu44941	XM_005253052.4 Latest version!	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu14240	NM_021932.5 Latest version!	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00
View Old Accession Versions >>
OHu92418	XM_017018107.1	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu44941	XM_005253052.3	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RIC8A ( XM_017018107.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016873596.1 Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X2, mRNA.

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CloneID	OHu92418
Clone ID Related Accession (Same CDS sequence)	XM_017018107.2 , XM_017018107.1
Accession Version	XM_017018107.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	synembryn-A isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017018107.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGTTG TACTGGAGTC CCTCAAGTGC CTGTGCAACC TCGTGCTCAG CAGCCCTGTG 
GCACAGATGC TGGCAGCAGA GGCCCGCCTA GTGGTGAAGC TCACAGAGCG TGTGGGGCTG 
TACCGTGAGA GGAGCTTCCC CCACGATGTC CAGTTCTTTG ACTTGCGGCT CCTCTTCCTG 
CTAACGGCAC TCCGCACCGA TGTGCGCCAG CAGCTGTTTC AGGAGCTGAA AGGAGTGCGC 
CTGCTAACTG ACACACTGGA GCTGACGCTG GGGGTGACTC CTGAAGGGAA CCCCCCACCC 
ACGCTCCTTC CTTCCCAAGA GACTGAGCGG GCCATGGAGA TCCTCAAAGT GCTCTTCAAC 
ATCACCCTGG ACTCCATCAA GGGGGAGGTG GACGAGGAAG ACGCTGCCCT TTACCGACAC 
CTGGGGACCC TTCTCCGGCA CTGTGTGATG ATCGCTACTG CTGGAGACCG CACAGAGGAG 
TTCCACGGCC ACGCAGTGAA CCTCCTGGGG AACTTGCCCC TCAAGTGTCT GGATGTTCTC 
CTCACCCTGG AGCCACATGG AGACTCCACG GAGTTCATGG GAGTGAATAT GGATGTGATT 
CGTGCCCTCC TCATCTTCCT AGAGAAGCGT TTGCACAAGA CACACAGGCT GAAGGAGAGT 
GTAGCTCCCG TGCTGAGCGT GCTGACTGAA TGTGCCCGGA TGCACCGCCC AGCCAGGAAG 
TTCCTGAAGG CCCAGGTGCT GCCCCCTCTG CGGGATGTGA GGACACGGCC TGAGGTTGGG 
GAGATGCTGC GGAACAAGCT TGTCCGCCTC ATGACACACC TGGACACAGA TGTGAAGAGG 
GTGGCTGCCG AGTTCTTGTT TGTCCTGTGC TCTGAGAGTG TGCCCCGATT CATCAAGTAC 
ACAGGCTATG GGAATGCTGC TGGCCTTCTG GCTGCCAGGG GCCTCATGGC AGGAGGCCGG 
CCCGAGGGCC AGTACTCAGA GGATGAGGAC ACAGACACAG ATGAGTACAA GGAAGCCAAA 
GCCAGCATAA ACCCTGTGAC CGGGAGGGTG GAGGAGAAGC CGCCTAACCC TATGGAGGGC 
ATGACAGAGG AGCAGAAGGA GCACGAGGCC ATGAAGCTGG TGACCATGTT TGACAAGCTC 
TCCAGGAACA GAGTCATCCA GCCAATGGGG ATGAGTCCCC GGGGTCATCT TACGTCCCTG 
CAGGATGCCA TGTGCGAGAC TATGGAGCAG CAGCTCTCCT CGGACCCTGA CTCGGACCCT 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016873596.1
CDS	1582..2847
Translation	MDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDSTEFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

Target ORF information:

RefSeq Version	XM_017018107.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017018107.2

ORF Insert Sequence:

ATGGATGTTG TACTGGAGTC CCTCAAGTGC CTGTGCAACC TCGTGCTCAG CAGCCCTGTG 
GCACAGATGC TGGCAGCAGA GGCCCGCCTA GTGGTGAAGC TCACAGAGCG TGTGGGGCTG 
TACCGTGAGA GGAGCTTCCC CCACGATGTC CAGTTCTTTG ACTTGCGGCT CCTCTTCCTG 
CTAACGGCAC TCCGCACCGA TGTGCGCCAG CAGCTGTTTC AGGAGCTGAA AGGAGTGCGC 
CTGCTAACTG ACACACTGGA GCTGACGCTG GGGGTGACTC CTGAAGGGAA CCCCCCACCC 
ACGCTCCTTC CTTCCCAAGA GACTGAGCGG GCCATGGAGA TCCTCAAAGT GCTCTTCAAC 
ATCACCCTGG ACTCCATCAA GGGGGAGGTG GACGAGGAAG ACGCTGCCCT TTACCGACAC 
CTGGGGACCC TTCTCCGGCA CTGTGTGATG ATCGCTACTG CTGGAGACCG CACAGAGGAG 
TTCCACGGCC ACGCAGTGAA CCTCCTGGGG AACTTGCCCC TCAAGTGTCT GGATGTTCTC 
CTCACCCTGG AGCCACATGG AGACTCCACG GAGTTCATGG GAGTGAATAT GGATGTGATT 
CGTGCCCTCC TCATCTTCCT AGAGAAGCGT TTGCACAAGA CACACAGGCT GAAGGAGAGT 
GTAGCTCCCG TGCTGAGCGT GCTGACTGAA TGTGCCCGGA TGCACCGCCC AGCCAGGAAG 
TTCCTGAAGG CCCAGGTGCT GCCCCCTCTG CGGGATGTGA GGACACGGCC TGAGGTTGGG 
GAGATGCTGC GGAACAAGCT TGTCCGCCTC ATGACACACC TGGACACAGA TGTGAAGAGG 
GTGGCTGCCG AGTTCTTGTT TGTCCTGTGC TCTGAGAGTG TGCCCCGATT CATCAAGTAC 
ACAGGCTATG GGAATGCTGC TGGCCTTCTG GCTGCCAGGG GCCTCATGGC AGGAGGCCGG 
CCCGAGGGCC AGTACTCAGA GGATGAGGAC ACAGACACAG ATGAGTACAA GGAAGCCAAA 
GCCAGCATAA ACCCTGTGAC CGGGAGGGTG GAGGAGAAGC CGCCTAACCC TATGGAGGGC 
ATGACAGAGG AGCAGAAGGA GCACGAGGCC ATGAAGCTGG TGACCATGTT TGACAAGCTC 
TCCAGGAACA GAGTCATCCA GCCAATGGGG ATGAGTCCCC GGGGTCATCT TACGTCCCTG 
CAGGATGCCA TGTGCGAGAC TATGGAGCAG CAGCTCTCCT CGGACCCTGA CTCGGACCCT 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIC8A ( XM_017018107.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016873596.1 Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu92418
Clone ID Related Accession (Same CDS sequence)	XM_017018107.2 , XM_017018107.1
Accession Version	XM_017018107.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	synembryn-A isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGTTG TACTGGAGTC CCTCAAGTGC CTGTGCAACC TCGTGCTCAG CAGCCCTGTG 
GCACAGATGC TGGCAGCAGA GGCCCGCCTA GTGGTGAAGC TCACAGAGCG TGTGGGGCTG 
TACCGTGAGA GGAGCTTCCC CCACGATGTC CAGTTCTTTG ACTTGCGGCT CCTCTTCCTG 
CTAACGGCAC TCCGCACCGA TGTGCGCCAG CAGCTGTTTC AGGAGCTGAA AGGAGTGCGC 
CTGCTAACTG ACACACTGGA GCTGACGCTG GGGGTGACTC CTGAAGGGAA CCCCCCACCC 
ACGCTCCTTC CTTCCCAAGA GACTGAGCGG GCCATGGAGA TCCTCAAAGT GCTCTTCAAC 
ATCACCCTGG ACTCCATCAA GGGGGAGGTG GACGAGGAAG ACGCTGCCCT TTACCGACAC 
CTGGGGACCC TTCTCCGGCA CTGTGTGATG ATCGCTACTG CTGGAGACCG CACAGAGGAG 
TTCCACGGCC ACGCAGTGAA CCTCCTGGGG AACTTGCCCC TCAAGTGTCT GGATGTTCTC 
CTCACCCTGG AGCCACATGG AGACTCCACG GAGTTCATGG GAGTGAATAT GGATGTGATT 
CGTGCCCTCC TCATCTTCCT AGAGAAGCGT TTGCACAAGA CACACAGGCT GAAGGAGAGT 
GTAGCTCCCG TGCTGAGCGT GCTGACTGAA TGTGCCCGGA TGCACCGCCC AGCCAGGAAG 
TTCCTGAAGG CCCAGGTGCT GCCCCCTCTG CGGGATGTGA GGACACGGCC TGAGGTTGGG 
GAGATGCTGC GGAACAAGCT TGTCCGCCTC ATGACACACC TGGACACAGA TGTGAAGAGG 
GTGGCTGCCG AGTTCTTGTT TGTCCTGTGC TCTGAGAGTG TGCCCCGATT CATCAAGTAC 
ACAGGCTATG GGAATGCTGC TGGCCTTCTG GCTGCCAGGG GCCTCATGGC AGGAGGCCGG 
CCCGAGGGCC AGTACTCAGA GGATGAGGAC ACAGACACAG ATGAGTACAA GGAAGCCAAA 
GCCAGCATAA ACCCTGTGAC CGGGAGGGTG GAGGAGAAGC CGCCTAACCC TATGGAGGGC 
ATGACAGAGG AGCAGAAGGA GCACGAGGCC ATGAAGCTGG TGACCATGTT TGACAAGCTC 
TCCAGGAACA GAGTCATCCA GCCAATGGGG ATGAGTCCCC GGGGTCATCT TACGTCCCTG 
CAGGATGCCA TGTGCGAGAC TATGGAGCAG CAGCTCTCCT CGGACCCTGA CTCGGACCCT 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016873596.1
CDS	945..2210
Translation	MDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDSTEFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

Target ORF information:

RefSeq Version	XM_017018107.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017018107.1

ORF Insert Sequence:

ATGGATGTTG TACTGGAGTC CCTCAAGTGC CTGTGCAACC TCGTGCTCAG CAGCCCTGTG 
GCACAGATGC TGGCAGCAGA GGCCCGCCTA GTGGTGAAGC TCACAGAGCG TGTGGGGCTG 
TACCGTGAGA GGAGCTTCCC CCACGATGTC CAGTTCTTTG ACTTGCGGCT CCTCTTCCTG 
CTAACGGCAC TCCGCACCGA TGTGCGCCAG CAGCTGTTTC AGGAGCTGAA AGGAGTGCGC 
CTGCTAACTG ACACACTGGA GCTGACGCTG GGGGTGACTC CTGAAGGGAA CCCCCCACCC 
ACGCTCCTTC CTTCCCAAGA GACTGAGCGG GCCATGGAGA TCCTCAAAGT GCTCTTCAAC 
ATCACCCTGG ACTCCATCAA GGGGGAGGTG GACGAGGAAG ACGCTGCCCT TTACCGACAC 
CTGGGGACCC TTCTCCGGCA CTGTGTGATG ATCGCTACTG CTGGAGACCG CACAGAGGAG 
TTCCACGGCC ACGCAGTGAA CCTCCTGGGG AACTTGCCCC TCAAGTGTCT GGATGTTCTC 
CTCACCCTGG AGCCACATGG AGACTCCACG GAGTTCATGG GAGTGAATAT GGATGTGATT 
CGTGCCCTCC TCATCTTCCT AGAGAAGCGT TTGCACAAGA CACACAGGCT GAAGGAGAGT 
GTAGCTCCCG TGCTGAGCGT GCTGACTGAA TGTGCCCGGA TGCACCGCCC AGCCAGGAAG 
TTCCTGAAGG CCCAGGTGCT GCCCCCTCTG CGGGATGTGA GGACACGGCC TGAGGTTGGG 
GAGATGCTGC GGAACAAGCT TGTCCGCCTC ATGACACACC TGGACACAGA TGTGAAGAGG 
GTGGCTGCCG AGTTCTTGTT TGTCCTGTGC TCTGAGAGTG TGCCCCGATT CATCAAGTAC 
ACAGGCTATG GGAATGCTGC TGGCCTTCTG GCTGCCAGGG GCCTCATGGC AGGAGGCCGG 
CCCGAGGGCC AGTACTCAGA GGATGAGGAC ACAGACACAG ATGAGTACAA GGAAGCCAAA 
GCCAGCATAA ACCCTGTGAC CGGGAGGGTG GAGGAGAAGC CGCCTAACCC TATGGAGGGC 
ATGACAGAGG AGCAGAAGGA GCACGAGGCC ATGAAGCTGG TGACCATGTT TGACAAGCTC 
TCCAGGAACA GAGTCATCCA GCCAATGGGG ATGAGTCCCC GGGGTCATCT TACGTCCCTG 
CAGGATGCCA TGTGCGAGAC TATGGAGCAG CAGCTCTCCT CGGACCCTGA CTCGGACCCT 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIC8A ( NM_001286134.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001273063.1 Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14387
Clone ID Related Accession (Same CDS sequence)	NM_001286134.1
Accession Version	NM_001286134.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1596bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571587200000
Organism	Homo sapiens(human)
Product	synembryn-A isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC069287.7, AK026897.1 and AL136935.1. On Oct 30, 2013 this sequence version replaced XM_005253053.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK026897.1, SRR1803615.231479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA 
GCTCTGCGGT CATACAACCA GGAGCACTCC CAGAGCTTCA CGTTTGATGA TGCCCAACAG 
GAGGACCGGA AGAGACTGGC GGAGCTGCTG GTCTCCGTCC TGGAACAGGG CTTGCCACCC 
TCCCACCGTG TCATCTGGCT GCAGAGTGTC CGAATCCTGT CCCGGGACCG CAACTGCCTG 
GACCCGTTCA CCAGCCGCCA GAGCCTGCAG GCACTAGCCT GCTATGCTGA CATCTCTGTC 
TCTGAGGGGT CCGTCCCAGA GTCCGCAGAC ATGGATGTTG TACTGGAGTC CCTCAAGTGC 
CTGTGCAACC TCGTGCTCAG CAGCCCTGTG GCACAGATGC TGGCAGCAGA GGCCCGCCTA 
GTGGTGAAGC TCACAGAGCG TGTGGGGCTG TACCGTGAGA GGAGCTTCCC CCACGATGTC 
CAGTTCTTTG ACTTGCGGCT CCTCTTCCTG CTAACGGCAC TCCGCACCGA TGTGCGCCAG 
CAGCTGTTTC AGGAGCTGAA AGGAGTGCGC CTGCTAACTG ACACACTGGA GCTGACGCTG 
GGGGTGACTC CTGAAGGGAA CCCCCCACCC ACGCTCCTTC CTTCCCAAGA GACTGAGCGG 
GCCATGGAGA TCCTCAAAGT GCTCTTCAAC ATCACCCTGG ACTCCATCAA GGGGGAGGTG 
GACGAGGAAG ACGCTGCCCT TTACCGACAC CTGGGGACCC TTCTCCGGCA CTGTGTGATG 
ATCGCTACTG CTGGAGACCG CACAGAGGAG TTCCACGGCC ACGCAGTGAA CCTCCTGGGG 
AACTTGCCCC TCAAGTGTCT GGATGTTCTC CTCACCCTGG AGCCACATGG AGACTCCACG 
GAGTTCATGG GAGTGAATAT GGATGTGATT CGTGCCCTCC TCATCTTCCT AGAGAAGCGT 
TTGCACAAGA CACACAGGCT GAAGGAGAGT GTAGCTCCCG TGCTGAGCGT GCTGACTGAA 
TGTGCCCGGA TGCACCGCCC AGCCAGGAAG TTCCTGAAGG CCCAGGTGCT GCCCCCTCTG 
CGGGATGTGA GGACACGGCC TGAGGTTGGG GAGATGCTGC GGAACAAGCT TGTCCGCCTC 
ATGACACACC TGGACACAGA TGTGAAGAGG GTGGCTGCCG AGTTCTTGTT TGTCCTGTGC 
TCTGAGAGTG TGCCCCGATT CATCAAGTAC ACAGGCTATG GGAATGCTGC TGGCCTTCTG 
GCTGCCAGGG GCCTCATGGC AGGAGGCCGG CCCGAGGGCC AGTACTCAGA GGATGAGGAC 
ACAGACACAG ATGAGTACAA GGAAGCCAAA GCCAGCATAA ACCCTGTGAC CGGGAGGGTG 
GAGGAGAAGC CGCCTAACCC TATGGAGGGC ATGACAGAGG AGCAGAAGGA GCACGAGGCC 
ATGAAGCTGG TGACCATGTT TGACAAGCTC TCCAGGAACA GAGTCATCCA GCCAATGGGG 
ATGAGTCCCC GGGGTCATCT TACGTCCCTG CAGGATGCCA TGTGCGAGAC TATGGAGCAG 
CAGCTCTCCT CGGACCCTGA CTCGGACCCT GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273063.1
CDS	1345..2940
Translation	MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPPSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDSTEFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

Target ORF information:

RefSeq Version	NM_001286134.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286134.1

ORF Insert Sequence:

ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA 
GCTCTGCGGT CATACAACCA GGAGCACTCC CAGAGCTTCA CGTTTGATGA TGCCCAACAG 
GAGGACCGGA AGAGACTGGC GGAGCTGCTG GTCTCCGTCC TGGAACAGGG CTTGCCACCC 
TCCCACCGTG TCATCTGGCT GCAGAGTGTC CGAATCCTGT CCCGGGACCG CAACTGCCTG 
GACCCGTTCA CCAGCCGCCA GAGCCTGCAG GCACTAGCCT GCTATGCTGA CATCTCTGTC 
TCTGAGGGGT CCGTCCCAGA GTCCGCAGAC ATGGATGTTG TACTGGAGTC CCTCAAGTGC 
CTGTGCAACC TCGTGCTCAG CAGCCCTGTG GCACAGATGC TGGCAGCAGA GGCCCGCCTA 
GTGGTGAAGC TCACAGAGCG TGTGGGGCTG TACCGTGAGA GGAGCTTCCC CCACGATGTC 
CAGTTCTTTG ACTTGCGGCT CCTCTTCCTG CTAACGGCAC TCCGCACCGA TGTGCGCCAG 
CAGCTGTTTC AGGAGCTGAA AGGAGTGCGC CTGCTAACTG ACACACTGGA GCTGACGCTG 
GGGGTGACTC CTGAAGGGAA CCCCCCACCC ACGCTCCTTC CTTCCCAAGA GACTGAGCGG 
GCCATGGAGA TCCTCAAAGT GCTCTTCAAC ATCACCCTGG ACTCCATCAA GGGGGAGGTG 
GACGAGGAAG ACGCTGCCCT TTACCGACAC CTGGGGACCC TTCTCCGGCA CTGTGTGATG 
ATCGCTACTG CTGGAGACCG CACAGAGGAG TTCCACGGCC ACGCAGTGAA CCTCCTGGGG 
AACTTGCCCC TCAAGTGTCT GGATGTTCTC CTCACCCTGG AGCCACATGG AGACTCCACG 
GAGTTCATGG GAGTGAATAT GGATGTGATT CGTGCCCTCC TCATCTTCCT AGAGAAGCGT 
TTGCACAAGA CACACAGGCT GAAGGAGAGT GTAGCTCCCG TGCTGAGCGT GCTGACTGAA 
TGTGCCCGGA TGCACCGCCC AGCCAGGAAG TTCCTGAAGG CCCAGGTGCT GCCCCCTCTG 
CGGGATGTGA GGACACGGCC TGAGGTTGGG GAGATGCTGC GGAACAAGCT TGTCCGCCTC 
ATGACACACC TGGACACAGA TGTGAAGAGG GTGGCTGCCG AGTTCTTGTT TGTCCTGTGC 
TCTGAGAGTG TGCCCCGATT CATCAAGTAC ACAGGCTATG GGAATGCTGC TGGCCTTCTG 
GCTGCCAGGG GCCTCATGGC AGGAGGCCGG CCCGAGGGCC AGTACTCAGA GGATGAGGAC 
ACAGACACAG ATGAGTACAA GGAAGCCAAA GCCAGCATAA ACCCTGTGAC CGGGAGGGTG 
GAGGAGAAGC CGCCTAACCC TATGGAGGGC ATGACAGAGG AGCAGAAGGA GCACGAGGCC 
ATGAAGCTGG TGACCATGTT TGACAAGCTC TCCAGGAACA GAGTCATCCA GCCAATGGGG 
ATGAGTCCCC GGGGTCATCT TACGTCCCTG CAGGATGCCA TGTGCGAGAC TATGGAGCAG 
CAGCTCTCCT CGGACCCTGA CTCGGACCCT GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIC8A ( XM_005253052.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005253109.1 Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X1, mRNA.

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CloneID	OHu44941
Clone ID Related Accession (Same CDS sequence)	XM_005253052.4 , XM_005253052.3
Accession Version	XM_005253052.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	synembryn-A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005253052.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA 
GCTCTGCGGT CATACAACCA GGAGTTCTCT CTGCAGCACT CCCAGAGCTT CACGTTTGAT 
GATGCCCAAC AGGAGGACCG GAAGAGACTG GCGGAGCTGC TGGTCTCCGT CCTGGAACAG 
GGCTTGCCAC CCTCCCACCG TGTCATCTGG CTGCAGAGTG TCCGAATCCT GTCCCGGGAC 
CGCAACTGCC TGGACCCGTT CACCAGCCGC CAGAGCCTGC AGGCACTAGC CTGCTATGCT 
GACATCTCTG TCTCTGAGGG GTCCGTCCCA GAGTCCGCAG ACATGGATGT TGTACTGGAG 
TCCCTCAAGT GCCTGTGCAA CCTCGTGCTC AGCAGCCCTG TGGCACAGAT GCTGGCAGCA 
GAGGCCCGCC TAGTGGTGAA GCTCACAGAG CGTGTGGGGC TGTACCGTGA GAGGAGCTTC 
CCCCACGATG TCCAGTTCTT TGACTTGCGG CTCCTCTTCC TGCTAACGGC ACTCCGCACC 
GATGTGCGCC AGCAGCTGTT TCAGGAGCTG AAAGGAGTGC GCCTGCTAAC TGACACACTG 
GAGCTGACGC TGGGGGTGAC TCCTGAAGGG AACCCCCCAC CCACGCTCCT TCCTTCCCAA 
GAGACTGAGC GGGCCATGGA GATCCTCAAA GTGCTCTTCA ACATCACCCT GGACTCCATC 
AAGGGGGAGG TGGACGAGGA AGACGCTGCC CTTTACCGAC ACCTGGGGAC CCTTCTCCGG 
CACTGTGTGA TGATCGCTAC TGCTGGAGAC CGCACAGAGG AGTTCCACGG CCACGCAGTG 
AACCTCCTGG GGAACTTGCC CCTCAAGTGT CTGGATGTTC TCCTCACCCT GGAGCCACAT 
GGAGACTCCA CGGAGTTCAT GGGAGTGAAT ATGGATGTGA TTCGTGCCCT CCTCATCTTC 
CTAGAGAAGC GTTTGCACAA GACACACAGG CTGAAGGAGA GTGTAGCTCC CGTGCTGAGC 
GTGCTGACTG AATGTGCCCG GATGCACCGC CCAGCCAGGA AGTTCCTGAA GGCCCAGGTG 
CTGCCCCCTC TGCGGGATGT GAGGACACGG CCTGAGGTTG GGGAGATGCT GCGGAACAAG 
CTTGTCCGCC TCATGACACA CCTGGACACA GATGTGAAGA GGGTGGCTGC CGAGTTCTTG 
TTTGTCCTGT GCTCTGAGAG TGTGCCCCGA TTCATCAAGT ACACAGGCTA TGGGAATGCT 
GCTGGCCTTC TGGCTGCCAG GGGCCTCATG GCAGGAGGCC GGCCCGAGGG CCAGTACTCA 
GAGGATGAGG ACACAGACAC AGATGAGTAC AAGGAAGCCA AAGCCAGCAT AAACCCTGTG 
ACCGGGAGGG TGGAGGAGAA GCCGCCTAAC CCTATGGAGG GCATGACAGA GGAGCAGAAG 
GAGCACGAGG CCATGAAGCT GGTGACCATG TTTGACAAGC TCTCCAGGAA CAGAGTCATC 
CAGCCAATGG GGATGAGTCC CCGGGGTCAT CTTACGTCCC TGCAGGATGC CATGTGCGAG 
ACTATGGAGC AGCAGCTCTC CTCGGACCCT GACTCGGACC CTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005253109.1
CDS	1156..2763
Translation	MEPRAVAEAVETGEEDVIMEALRSYNQEFSLQHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPPSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDSTEFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

Target ORF information:

RefSeq Version	XM_005253052.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005253052.4

ORF Insert Sequence:

ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA 
GCTCTGCGGT CATACAACCA GGAGTTCTCT CTGCAGCACT CCCAGAGCTT CACGTTTGAT 
GATGCCCAAC AGGAGGACCG GAAGAGACTG GCGGAGCTGC TGGTCTCCGT CCTGGAACAG 
GGCTTGCCAC CCTCCCACCG TGTCATCTGG CTGCAGAGTG TCCGAATCCT GTCCCGGGAC 
CGCAACTGCC TGGACCCGTT CACCAGCCGC CAGAGCCTGC AGGCACTAGC CTGCTATGCT 
GACATCTCTG TCTCTGAGGG GTCCGTCCCA GAGTCCGCAG ACATGGATGT TGTACTGGAG 
TCCCTCAAGT GCCTGTGCAA CCTCGTGCTC AGCAGCCCTG TGGCACAGAT GCTGGCAGCA 
GAGGCCCGCC TAGTGGTGAA GCTCACAGAG CGTGTGGGGC TGTACCGTGA GAGGAGCTTC 
CCCCACGATG TCCAGTTCTT TGACTTGCGG CTCCTCTTCC TGCTAACGGC ACTCCGCACC 
GATGTGCGCC AGCAGCTGTT TCAGGAGCTG AAAGGAGTGC GCCTGCTAAC TGACACACTG 
GAGCTGACGC TGGGGGTGAC TCCTGAAGGG AACCCCCCAC CCACGCTCCT TCCTTCCCAA 
GAGACTGAGC GGGCCATGGA GATCCTCAAA GTGCTCTTCA ACATCACCCT GGACTCCATC 
AAGGGGGAGG TGGACGAGGA AGACGCTGCC CTTTACCGAC ACCTGGGGAC CCTTCTCCGG 
CACTGTGTGA TGATCGCTAC TGCTGGAGAC CGCACAGAGG AGTTCCACGG CCACGCAGTG 
AACCTCCTGG GGAACTTGCC CCTCAAGTGT CTGGATGTTC TCCTCACCCT GGAGCCACAT 
GGAGACTCCA CGGAGTTCAT GGGAGTGAAT ATGGATGTGA TTCGTGCCCT CCTCATCTTC 
CTAGAGAAGC GTTTGCACAA GACACACAGG CTGAAGGAGA GTGTAGCTCC CGTGCTGAGC 
GTGCTGACTG AATGTGCCCG GATGCACCGC CCAGCCAGGA AGTTCCTGAA GGCCCAGGTG 
CTGCCCCCTC TGCGGGATGT GAGGACACGG CCTGAGGTTG GGGAGATGCT GCGGAACAAG 
CTTGTCCGCC TCATGACACA CCTGGACACA GATGTGAAGA GGGTGGCTGC CGAGTTCTTG 
TTTGTCCTGT GCTCTGAGAG TGTGCCCCGA TTCATCAAGT ACACAGGCTA TGGGAATGCT 
GCTGGCCTTC TGGCTGCCAG GGGCCTCATG GCAGGAGGCC GGCCCGAGGG CCAGTACTCA 
GAGGATGAGG ACACAGACAC AGATGAGTAC AAGGAAGCCA AAGCCAGCAT AAACCCTGTG 
ACCGGGAGGG TGGAGGAGAA GCCGCCTAAC CCTATGGAGG GCATGACAGA GGAGCAGAAG 
GAGCACGAGG CCATGAAGCT GGTGACCATG TTTGACAAGC TCTCCAGGAA CAGAGTCATC 
CAGCCAATGG GGATGAGTCC CCGGGGTCAT CTTACGTCCC TGCAGGATGC CATGTGCGAG 
ACTATGGAGC AGCAGCTCTC CTCGGACCCT GACTCGGACC CTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIC8A ( XM_005253052.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005253109.1 Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X1, mRNA.

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CloneID	OHu44941
Clone ID Related Accession (Same CDS sequence)	XM_005253052.4 , XM_005253052.3
Accession Version	XM_005253052.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	synembryn-A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005253052.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA 
GCTCTGCGGT CATACAACCA GGAGTTCTCT CTGCAGCACT CCCAGAGCTT CACGTTTGAT 
GATGCCCAAC AGGAGGACCG GAAGAGACTG GCGGAGCTGC TGGTCTCCGT CCTGGAACAG 
GGCTTGCCAC CCTCCCACCG TGTCATCTGG CTGCAGAGTG TCCGAATCCT GTCCCGGGAC 
CGCAACTGCC TGGACCCGTT CACCAGCCGC CAGAGCCTGC AGGCACTAGC CTGCTATGCT 
GACATCTCTG TCTCTGAGGG GTCCGTCCCA GAGTCCGCAG ACATGGATGT TGTACTGGAG 
TCCCTCAAGT GCCTGTGCAA CCTCGTGCTC AGCAGCCCTG TGGCACAGAT GCTGGCAGCA 
GAGGCCCGCC TAGTGGTGAA GCTCACAGAG CGTGTGGGGC TGTACCGTGA GAGGAGCTTC 
CCCCACGATG TCCAGTTCTT TGACTTGCGG CTCCTCTTCC TGCTAACGGC ACTCCGCACC 
GATGTGCGCC AGCAGCTGTT TCAGGAGCTG AAAGGAGTGC GCCTGCTAAC TGACACACTG 
GAGCTGACGC TGGGGGTGAC TCCTGAAGGG AACCCCCCAC CCACGCTCCT TCCTTCCCAA 
GAGACTGAGC GGGCCATGGA GATCCTCAAA GTGCTCTTCA ACATCACCCT GGACTCCATC 
AAGGGGGAGG TGGACGAGGA AGACGCTGCC CTTTACCGAC ACCTGGGGAC CCTTCTCCGG 
CACTGTGTGA TGATCGCTAC TGCTGGAGAC CGCACAGAGG AGTTCCACGG CCACGCAGTG 
AACCTCCTGG GGAACTTGCC CCTCAAGTGT CTGGATGTTC TCCTCACCCT GGAGCCACAT 
GGAGACTCCA CGGAGTTCAT GGGAGTGAAT ATGGATGTGA TTCGTGCCCT CCTCATCTTC 
CTAGAGAAGC GTTTGCACAA GACACACAGG CTGAAGGAGA GTGTAGCTCC CGTGCTGAGC 
GTGCTGACTG AATGTGCCCG GATGCACCGC CCAGCCAGGA AGTTCCTGAA GGCCCAGGTG 
CTGCCCCCTC TGCGGGATGT GAGGACACGG CCTGAGGTTG GGGAGATGCT GCGGAACAAG 
CTTGTCCGCC TCATGACACA CCTGGACACA GATGTGAAGA GGGTGGCTGC CGAGTTCTTG 
TTTGTCCTGT GCTCTGAGAG TGTGCCCCGA TTCATCAAGT ACACAGGCTA TGGGAATGCT 
GCTGGCCTTC TGGCTGCCAG GGGCCTCATG GCAGGAGGCC GGCCCGAGGG CCAGTACTCA 
GAGGATGAGG ACACAGACAC AGATGAGTAC AAGGAAGCCA AAGCCAGCAT AAACCCTGTG 
ACCGGGAGGG TGGAGGAGAA GCCGCCTAAC CCTATGGAGG GCATGACAGA GGAGCAGAAG 
GAGCACGAGG CCATGAAGCT GGTGACCATG TTTGACAAGC TCTCCAGGAA CAGAGTCATC 
CAGCCAATGG GGATGAGTCC CCGGGGTCAT CTTACGTCCC TGCAGGATGC CATGTGCGAG 
ACTATGGAGC AGCAGCTCTC CTCGGACCCT GACTCGGACC CTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005253109.1
CDS	519..2126
Translation	MEPRAVAEAVETGEEDVIMEALRSYNQEFSLQHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPPSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDSTEFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

Target ORF information:

RefSeq Version	XM_005253052.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005253052.3

ORF Insert Sequence:

ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA 
GCTCTGCGGT CATACAACCA GGAGTTCTCT CTGCAGCACT CCCAGAGCTT CACGTTTGAT 
GATGCCCAAC AGGAGGACCG GAAGAGACTG GCGGAGCTGC TGGTCTCCGT CCTGGAACAG 
GGCTTGCCAC CCTCCCACCG TGTCATCTGG CTGCAGAGTG TCCGAATCCT GTCCCGGGAC 
CGCAACTGCC TGGACCCGTT CACCAGCCGC CAGAGCCTGC AGGCACTAGC CTGCTATGCT 
GACATCTCTG TCTCTGAGGG GTCCGTCCCA GAGTCCGCAG ACATGGATGT TGTACTGGAG 
TCCCTCAAGT GCCTGTGCAA CCTCGTGCTC AGCAGCCCTG TGGCACAGAT GCTGGCAGCA 
GAGGCCCGCC TAGTGGTGAA GCTCACAGAG CGTGTGGGGC TGTACCGTGA GAGGAGCTTC 
CCCCACGATG TCCAGTTCTT TGACTTGCGG CTCCTCTTCC TGCTAACGGC ACTCCGCACC 
GATGTGCGCC AGCAGCTGTT TCAGGAGCTG AAAGGAGTGC GCCTGCTAAC TGACACACTG 
GAGCTGACGC TGGGGGTGAC TCCTGAAGGG AACCCCCCAC CCACGCTCCT TCCTTCCCAA 
GAGACTGAGC GGGCCATGGA GATCCTCAAA GTGCTCTTCA ACATCACCCT GGACTCCATC 
AAGGGGGAGG TGGACGAGGA AGACGCTGCC CTTTACCGAC ACCTGGGGAC CCTTCTCCGG 
CACTGTGTGA TGATCGCTAC TGCTGGAGAC CGCACAGAGG AGTTCCACGG CCACGCAGTG 
AACCTCCTGG GGAACTTGCC CCTCAAGTGT CTGGATGTTC TCCTCACCCT GGAGCCACAT 
GGAGACTCCA CGGAGTTCAT GGGAGTGAAT ATGGATGTGA TTCGTGCCCT CCTCATCTTC 
CTAGAGAAGC GTTTGCACAA GACACACAGG CTGAAGGAGA GTGTAGCTCC CGTGCTGAGC 
GTGCTGACTG AATGTGCCCG GATGCACCGC CCAGCCAGGA AGTTCCTGAA GGCCCAGGTG 
CTGCCCCCTC TGCGGGATGT GAGGACACGG CCTGAGGTTG GGGAGATGCT GCGGAACAAG 
CTTGTCCGCC TCATGACACA CCTGGACACA GATGTGAAGA GGGTGGCTGC CGAGTTCTTG 
TTTGTCCTGT GCTCTGAGAG TGTGCCCCGA TTCATCAAGT ACACAGGCTA TGGGAATGCT 
GCTGGCCTTC TGGCTGCCAG GGGCCTCATG GCAGGAGGCC GGCCCGAGGG CCAGTACTCA 
GAGGATGAGG ACACAGACAC AGATGAGTAC AAGGAAGCCA AAGCCAGCAT AAACCCTGTG 
ACCGGGAGGG TGGAGGAGAA GCCGCCTAAC CCTATGGAGG GCATGACAGA GGAGCAGAAG 
GAGCACGAGG CCATGAAGCT GGTGACCATG TTTGACAAGC TCTCCAGGAA CAGAGTCATC 
CAGCCAATGG GGATGAGTCC CCGGGGTCAT CTTACGTCCC TGCAGGATGC CATGTGCGAG 
ACTATGGAGC AGCAGCTCTC CTCGGACCCT GACTCGGACC CTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIC8A ( NM_021932.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_068751.4 Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant 1, mRNA.

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CloneID	OHu14240
Clone ID Related Accession (Same CDS sequence)	NM_021932.5
Accession Version	NM_021932.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571587200000
Organism	Homo sapiens(human)
Product	synembryn-A isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC069287.7, AK026897.1 and AL136935.1. On Oct 30, 2013 this sequence version replaced NM_021932.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL136935.1, SRR1803611.241919.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA 
GCTCTGCGGT CATACAACCA GGAGCACTCC CAGAGCTTCA CGTTTGATGA TGCCCAACAG 
GAGGACCGGA AGAGACTGGC GGAGCTGCTG GTCTCCGTCC TGGAACAGGG CTTGCCACCC 
TCCCACCGTG TCATCTGGCT GCAGAGTGTC CGAATCCTGT CCCGGGACCG CAACTGCCTG 
GACCCGTTCA CCAGCCGCCA GAGCCTGCAG GCACTAGCCT GCTATGCTGA CATCTCTGTC 
TCTGAGGGGT CCGTCCCAGA GTCCGCAGAC ATGGATGTTG TACTGGAGTC CCTCAAGTGC 
CTGTGCAACC TCGTGCTCAG CAGCCCTGTG GCACAGATGC TGGCAGCAGA GGCCCGCCTA 
GTGGTGAAGC TCACAGAGCG TGTGGGGCTG TACCGTGAGA GGAGCTTCCC CCACGATGTC 
CAGTTCTTTG ACTTGCGGCT CCTCTTCCTG CTAACGGCAC TCCGCACCGA TGTGCGCCAG 
CAGCTGTTTC AGGAGCTGAA AGGAGTGCGC CTGCTAACTG ACACACTGGA GCTGACGCTG 
GGGGTGACTC CTGAAGGGAA CCCCCCACCC ACGCTCCTTC CTTCCCAAGA GACTGAGCGG 
GCCATGGAGA TCCTCAAAGT GCTCTTCAAC ATCACCCTGG ACTCCATCAA GGGGGAGGTG 
GACGAGGAAG ACGCTGCCCT TTACCGACAC CTGGGGACCC TTCTCCGGCA CTGTGTGATG 
ATCGCTACTG CTGGAGACCG CACAGAGGAG TTCCACGGCC ACGCAGTGAA CCTCCTGGGG 
AACTTGCCCC TCAAGTGTCT GGATGTTCTC CTCACCCTGG AGCCACATGG AGACTCCACG 
GAGTTCATGG GAGTGAATAT GGATGTGATT CGTGCCCTCC TCATCTTCCT AGAGAAGCGT 
TTGCACAAGA CACACAGGCT GAAGGAGAGT GTAGCTCCCG TGCTGAGCGT GCTGACTGAA 
TGTGCCCGGA TGCACCGCCC AGCCAGGAAG TTCCTGAAGG CCCAGGGATG GCCACCTCCC 
CAGGTGCTGC CCCCTCTGCG GGATGTGAGG ACACGGCCTG AGGTTGGGGA GATGCTGCGG 
AACAAGCTTG TCCGCCTCAT GACACACCTG GACACAGATG TGAAGAGGGT GGCTGCCGAG 
TTCTTGTTTG TCCTGTGCTC TGAGAGTGTG CCCCGATTCA TCAAGTACAC AGGCTATGGG 
AATGCTGCTG GCCTTCTGGC TGCCAGGGGC CTCATGGCAG GAGGCCGGCC CGAGGGCCAG 
TACTCAGAGG ATGAGGACAC AGACACAGAT GAGTACAAGG AAGCCAAAGC CAGCATAAAC 
CCTGTGACCG GGAGGGTGGA GGAGAAGCCG CCTAACCCTA TGGAGGGCAT GACAGAGGAG 
CAGAAGGAGC ACGAGGCCAT GAAGCTGGTG ACCATGTTTG ACAAGCTCTC CAGGAACAGA 
GTCATCCAGC CAATGGGGAT GAGTCCCCGG GGTCATCTTA CGTCCCTGCA GGATGCCATG 
TGCGAGACTA TGGAGCAGCA GCTCTCCTCG GACCCTGACT CGGACCCTGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068751.4
CDS	1345..2958
Translation	MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPPSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDSTEFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQGWPPPQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD

Target ORF information:

RefSeq Version	NM_021932.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021932.5

ORF Insert Sequence:

ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA 
GCTCTGCGGT CATACAACCA GGAGCACTCC CAGAGCTTCA CGTTTGATGA TGCCCAACAG 
GAGGACCGGA AGAGACTGGC GGAGCTGCTG GTCTCCGTCC TGGAACAGGG CTTGCCACCC 
TCCCACCGTG TCATCTGGCT GCAGAGTGTC CGAATCCTGT CCCGGGACCG CAACTGCCTG 
GACCCGTTCA CCAGCCGCCA GAGCCTGCAG GCACTAGCCT GCTATGCTGA CATCTCTGTC 
TCTGAGGGGT CCGTCCCAGA GTCCGCAGAC ATGGATGTTG TACTGGAGTC CCTCAAGTGC 
CTGTGCAACC TCGTGCTCAG CAGCCCTGTG GCACAGATGC TGGCAGCAGA GGCCCGCCTA 
GTGGTGAAGC TCACAGAGCG TGTGGGGCTG TACCGTGAGA GGAGCTTCCC CCACGATGTC 
CAGTTCTTTG ACTTGCGGCT CCTCTTCCTG CTAACGGCAC TCCGCACCGA TGTGCGCCAG 
CAGCTGTTTC AGGAGCTGAA AGGAGTGCGC CTGCTAACTG ACACACTGGA GCTGACGCTG 
GGGGTGACTC CTGAAGGGAA CCCCCCACCC ACGCTCCTTC CTTCCCAAGA GACTGAGCGG 
GCCATGGAGA TCCTCAAAGT GCTCTTCAAC ATCACCCTGG ACTCCATCAA GGGGGAGGTG 
GACGAGGAAG ACGCTGCCCT TTACCGACAC CTGGGGACCC TTCTCCGGCA CTGTGTGATG 
ATCGCTACTG CTGGAGACCG CACAGAGGAG TTCCACGGCC ACGCAGTGAA CCTCCTGGGG 
AACTTGCCCC TCAAGTGTCT GGATGTTCTC CTCACCCTGG AGCCACATGG AGACTCCACG 
GAGTTCATGG GAGTGAATAT GGATGTGATT CGTGCCCTCC TCATCTTCCT AGAGAAGCGT 
TTGCACAAGA CACACAGGCT GAAGGAGAGT GTAGCTCCCG TGCTGAGCGT GCTGACTGAA 
TGTGCCCGGA TGCACCGCCC AGCCAGGAAG TTCCTGAAGG CCCAGGGATG GCCACCTCCC 
CAGGTGCTGC CCCCTCTGCG GGATGTGAGG ACACGGCCTG AGGTTGGGGA GATGCTGCGG 
AACAAGCTTG TCCGCCTCAT GACACACCTG GACACAGATG TGAAGAGGGT GGCTGCCGAG 
TTCTTGTTTG TCCTGTGCTC TGAGAGTGTG CCCCGATTCA TCAAGTACAC AGGCTATGGG 
AATGCTGCTG GCCTTCTGGC TGCCAGGGGC CTCATGGCAG GAGGCCGGCC CGAGGGCCAG 
TACTCAGAGG ATGAGGACAC AGACACAGAT GAGTACAAGG AAGCCAAAGC CAGCATAAAC 
CCTGTGACCG GGAGGGTGGA GGAGAAGCCG CCTAACCCTA TGGAGGGCAT GACAGAGGAG 
CAGAAGGAGC ACGAGGCCAT GAAGCTGGTG ACCATGTTTG ACAAGCTCTC CAGGAACAGA 
GTCATCCAGC CAATGGGGAT GAGTCCCCGG GGTCATCTTA CGTCCCTGCA GGATGCCATG 
TGCGAGACTA TGGAGCAGCA GCTCTCCTCG GACCCTGACT CGGACCCTGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange.
Science signaling11(532)(2018 05)
Papasergi-Scott MM,Stoveken HM,MacConnachie L,Chan PY,Gabay M,Wong D,Freeman RS,Beg AA,Tall GG

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα(i3).
Molecular and cellular biochemistry401(1-2)27-38(2015 Mar)
Tse MK,Morris CJ,Zhang M,Wong YH

The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release.
Journal of cell science127(Pt 19)4246-59(2014 Oct)
Romero-Pozuelo J,Dason JS,Mansilla A,Baños-Mateos S,Sardina JL,Chaves-Sanjuán A,Jurado-Gómez J,Santana E,Atwood HL,Hernández-Hernández Á,Sánchez-Barrena MJ,Ferrús A

Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity.
PloS one9(1)e86680(2014)
Boularan C,Kamenyeva O,Cho H,Kehrl JH

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
Human genetics133(1)95-109(2014 Jan)
Shameer K,Denny JC,Ding K,Jouni H,Crosslin DR,de Andrade M,Chute CG,Peissig P,Pacheco JA,Li R,Bastarache L,Kho AN,Ritchie MD,Masys DR,Chisholm RL,Larson EB,McCarty CA,Roden DM,Jarvik GP,Kullo IJ

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RIC8A cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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