RABGGTA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RABGGTA
Entrez Gene ID	5875
Full Name	Rab geranylgeranyltransferase alpha subunit
Synonyms	PTAR3
General protein information	Preferred Names Rab geranylgeranyltransferase alpha subunit Names geranylgeranyl transferase type-2 subunit alpha Rab GG transferase alpha Rab GGTase alpha geranylgeranyl transferase type II subunit alpha protein prenyltransferase alpha subunit repeat containing 3 rab geranyl-geranyltransferase subunit alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q12
Disorder MIM:	601905

mRNA and Protein(s)

mRNA	Protein	Name
NM_182836.2	NP_878256.1	geranylgeranyl transferase type-2 subunit alpha
XM_011537046.1	XP_011535348.1	geranylgeranyl transferase type-2 subunit alpha isoform X1
NM_004581.5	NP_004572.3	geranylgeranyl transferase type-2 subunit alpha

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	LOC714521	XP_001104317.1
Mus musculus (house mouse)	Rabggta	NP_062392.1
Drosophila melanogaster (fruit fly)	CG12007	NP_649512.1
Caenorhabditis elegans (roundworm)	M57.2	NP_500367.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009724	XP_318802.4
Bos taurus (cattle)	RABGGTA	NP_001015614.1
Pan troglodytes (chimpanzee)	RABGGTA	XP_509870.3
Xenopus tropicalis (tropical clawed frog)	rabggta	NP_001006728.1
Homo sapiens (human)	RABGGTA	NP_004572.3
Canis lupus familiaris (dog)	RABGGTA	XP_850528.1
Rattus norvegicus (Norway rat)	Rabggta	NP_113842.1
Danio rerio (zebrafish)	rabggta	NP_001070131.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Comprehensive mutation analysis (20 families) of the choroideremia gene reveals a missense variant that prevents the binding of REP1 with Rab geranylgeranyl transferase.
Esposito G, De Falco F, Tinto N, Testa F, Vitagliano L, Tandurella IC, Iannone L, Rossi S, Rinaldi E, Simonelli F, Zagari A, Salvatore F
Human mutation32(12)1460-9(2011 Dec)

Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB
Cancer prevention research (Philadelphia, Pa.)3(5)597-603(2010 May)

Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.
Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P, Souchelnytskyi S
Proteomics4(5)1346-58(2004 May)

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Pylypenko O, Rak A, Reents R, Niculae A, Sidorovitch V, Cioaca MD, Bessolitsyna E, Thomä NH, Waldmann H, Schlichting I, Goody RS, Alexandrov K
Molecular cell11(2)483-94(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RABGGTA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RABGGTA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02315	NM_182836.2 Latest version!	Homo sapiens Rab geranylgeranyltransferase subunit alpha (RABGGTA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu02315	NM_004581.5 Latest version!	Homo sapiens Rab geranylgeranyltransferase subunit alpha (RABGGTA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu02315	XM_011537046.1 Latest version!	Homo sapiens Rab geranylgeranyltransferase, alpha subunit (RABGGTA), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RABGGTA ( NM_182836.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_878256.1 Homo sapiens Rab geranylgeranyltransferase subunit alpha (RABGGTA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02315
Clone ID Related Accession (Same CDS sequence)	NM_182836.2 , XM_011537046.1 , NM_004581.5
Accession Version	NM_182836.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1704bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570550400000
Organism	Homo sapiens(human)
Product	geranylgeranyl transferase type-2 subunit alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA379718.1 and BC003093.1. On Feb 15, 2012 this sequence version replaced NM_182836.1. Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003093.1, SRR1163657.413001.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACGGAC GCCTGAAGGT GAAGACGTCA GAAGAGCAGG CGGAGGCCAA AAGGCTAGAG 
CGAGAGCAGA AGCTGAAGCT ATACCAGTCA GCCACCCAGG CCGTATTCCA GAAGCGCCAG 
GCTGGTGAGC TGGATGAGTC CGTGCTGGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGCCGACGA GAGGTGCTCC AGCAGCTGGA GACTCAGAAG 
TCTCCTGAAG AGTTGGCTGC TCTGGTGAAG GCAGAACTGG GCTTCCTGGA GAGCTGCCTG 
CGGGTGAACC CCAAGTCTTA TGGTACCTGG CACCACCGAT GCTGGCTGCT AGGCCGCCTG 
CCTGAGCCCA ACTGGACCCG AGAGCTGGAG CTCTGTGCCC GTTTCCTGGA GGTGGATGAG 
CGGAACTTTC ACTGCTGGGA CTATCGGCGG TTTGTGGCCA CACAGGCAGC CGTGCCCCCT 
GCAGAAGAGC TAGCCTTCAC TGACAGCCTC ATCACCCGAA ACTTCTCCAA CTACTCTTCC 
TGGCATTACC GCTCCTGTCT CTTGCCCCAG CTGCACCCCC AGCCGGATTC TGGACCACAG 
GGGCGCCTCC CTGAGGATGT GCTGCTCAAA GAGCTGGAGC TGGTGCAGAA TGCCTTCTTC 
ACTGACCCCA ATGACCAGAG TGCCTGGTTT TATCACCGTT GGCTCCTAGG CCGAGCTGAC 
CCCCAGGATG CACTGCGCTG CCTGCATGTG AGCCGGGACG AGGCCTGTCT GACTGTCTCC 
TTCTCTCGGC CCCTCTTAGT GGGCTCCAGG ATGGAGATCT TGCTGCTCAT GGTTGATGAT 
TCTCCCCTGA TTGTGGAGTG GAGGACCCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCCCTCAAC GACCAGTTGC CCCAACATAC ATTTCGCGTC 
ATTTGGACAG CAGGCGATGT CCAGAAAGAA TGCGTGCTTT TAAAAGGCCG CCAGGAGGGC 
TGGTGCCGGG ACTCCACGAC AGACGAGCAG CTATTCAGGT GTGAGCTGTC AGTGGAGAAG 
TCCACAGTGC TGCAGTCTGA GCTGGAATCC TGTAAGGAGC TGCAGGAGCT GGAGCCTGAG 
AATAAATGGT GCCTGCTTAC CATCATCCTG CTGATGCGGG CACTGGACCC CCTGCTGTAT 
GAGAAGGAGA CCCTGCAGTA CTTCCAGACC CTCAAGGCCG TGGACCCCAT GCGGGCAACG 
TATCTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAATA GCGTGCTCAA GATGGAGTAT 
GCCGAGGTGC GTGTGCTGCA CCTGGCTCAC AAGGATCTGA CAGTGCTCTG CCATCTGGAA 
CAGCTGCTCT TGGTCACCCA TCTTGACTTG TCACACAATC GCCTCCGAAC CCTGCCACCT 
GCACTGGCTG CCCTGCGCTG CCTTGAGGTG CTGCAGGCCA GTGATAATGC CATAGAGTCC 
CTGGACGGCG TCACCAACCT ACCCCGGCTG CAGGAGCTGC TACTGTGCAA CAACCGCCTC 
CAGCAGCCTG CAGTGCTCCA GCCTCTTGCC TCCTGCCCCA GGCTGGTCCT CCTCAACCTG 
CAGGGTAACC CGCTGTGCCA AGCGGTGGGC ATCTTGGAGC AACTGGCTGA ACTGCTGCCT 
TCAGTTAGCA GCGTCCTCAC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_878256.1
CDS	196..1899
Translation	MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVLT

Target ORF information:

RefSeq Version	NM_182836.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Rab geranylgeranyltransferase subunit alpha (RABGGTA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182836.2

ORF Insert Sequence:

ATGCACGGAC GCCTGAAGGT GAAGACGTCA GAAGAGCAGG CGGAGGCCAA AAGGCTAGAG 
CGAGAGCAGA AGCTGAAGCT ATACCAGTCA GCCACCCAGG CCGTATTCCA GAAGCGCCAG 
GCTGGTGAGC TGGATGAGTC CGTGCTGGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGCCGACGA GAGGTGCTCC AGCAGCTGGA GACTCAGAAG 
TCTCCTGAAG AGTTGGCTGC TCTGGTGAAG GCAGAACTGG GCTTCCTGGA GAGCTGCCTG 
CGGGTGAACC CCAAGTCTTA TGGTACCTGG CACCACCGAT GCTGGCTGCT AGGCCGCCTG 
CCTGAGCCCA ACTGGACCCG AGAGCTGGAG CTCTGTGCCC GTTTCCTGGA GGTGGATGAG 
CGGAACTTTC ACTGCTGGGA CTATCGGCGG TTTGTGGCCA CACAGGCAGC CGTGCCCCCT 
GCAGAAGAGC TAGCCTTCAC TGACAGCCTC ATCACCCGAA ACTTCTCCAA CTACTCTTCC 
TGGCATTACC GCTCCTGTCT CTTGCCCCAG CTGCACCCCC AGCCGGATTC TGGACCACAG 
GGGCGCCTCC CTGAGGATGT GCTGCTCAAA GAGCTGGAGC TGGTGCAGAA TGCCTTCTTC 
ACTGACCCCA ATGACCAGAG TGCCTGGTTT TATCACCGTT GGCTCCTAGG CCGAGCTGAC 
CCCCAGGATG CACTGCGCTG CCTGCATGTG AGCCGGGACG AGGCCTGTCT GACTGTCTCC 
TTCTCTCGGC CCCTCTTAGT GGGCTCCAGG ATGGAGATCT TGCTGCTCAT GGTTGATGAT 
TCTCCCCTGA TTGTGGAGTG GAGGACCCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCCCTCAAC GACCAGTTGC CCCAACATAC ATTTCGCGTC 
ATTTGGACAG CAGGCGATGT CCAGAAAGAA TGCGTGCTTT TAAAAGGCCG CCAGGAGGGC 
TGGTGCCGGG ACTCCACGAC AGACGAGCAG CTATTCAGGT GTGAGCTGTC AGTGGAGAAG 
TCCACAGTGC TGCAGTCTGA GCTGGAATCC TGTAAGGAGC TGCAGGAGCT GGAGCCTGAG 
AATAAATGGT GCCTGCTTAC CATCATCCTG CTGATGCGGG CACTGGACCC CCTGCTGTAT 
GAGAAGGAGA CCCTGCAGTA CTTCCAGACC CTCAAGGCCG TGGACCCCAT GCGGGCAACG 
TATCTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAATA GCGTGCTCAA GATGGAGTAT 
GCCGAGGTGC GTGTGCTGCA CCTGGCTCAC AAGGATCTGA CAGTGCTCTG CCATCTGGAA 
CAGCTGCTCT TGGTCACCCA TCTTGACTTG TCACACAATC GCCTCCGAAC CCTGCCACCT 
GCACTGGCTG CCCTGCGCTG CCTTGAGGTG CTGCAGGCCA GTGATAATGC CATAGAGTCC 
CTGGACGGCG TCACCAACCT ACCCCGGCTG CAGGAGCTGC TACTGTGCAA CAACCGCCTC 
CAGCAGCCTG CAGTGCTCCA GCCTCTTGCC TCCTGCCCCA GGCTGGTCCT CCTCAACCTG 
CAGGGTAACC CGCTGTGCCA AGCGGTGGGC ATCTTGGAGC AACTGGCTGA ACTGCTGCCT 
TCAGTTAGCA GCGTCCTCAC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RABGGTA ( NM_004581.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004572.3 Homo sapiens Rab geranylgeranyltransferase subunit alpha (RABGGTA), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02315
Clone ID Related Accession (Same CDS sequence)	NM_182836.2 , XM_011537046.1 , NM_004581.5
Accession Version	NM_004581.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1704bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570550400000
Organism	Homo sapiens(human)
Product	geranylgeranyl transferase type-2 subunit alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA379718.1, DB116988.1, AK292613.1 and BC003093.1. On Apr 24, 2012 this sequence version replaced NM_004581.4. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y08200.1, SRR1660807.124529.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACGGAC GCCTGAAGGT GAAGACGTCA GAAGAGCAGG CGGAGGCCAA AAGGCTAGAG 
CGAGAGCAGA AGCTGAAGCT ATACCAGTCA GCCACCCAGG CCGTATTCCA GAAGCGCCAG 
GCTGGTGAGC TGGATGAGTC CGTGCTGGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGCCGACGA GAGGTGCTCC AGCAGCTGGA GACTCAGAAG 
TCTCCTGAAG AGTTGGCTGC TCTGGTGAAG GCAGAACTGG GCTTCCTGGA GAGCTGCCTG 
CGGGTGAACC CCAAGTCTTA TGGTACCTGG CACCACCGAT GCTGGCTGCT AGGCCGCCTG 
CCTGAGCCCA ACTGGACCCG AGAGCTGGAG CTCTGTGCCC GTTTCCTGGA GGTGGATGAG 
CGGAACTTTC ACTGCTGGGA CTATCGGCGG TTTGTGGCCA CACAGGCAGC CGTGCCCCCT 
GCAGAAGAGC TAGCCTTCAC TGACAGCCTC ATCACCCGAA ACTTCTCCAA CTACTCTTCC 
TGGCATTACC GCTCCTGTCT CTTGCCCCAG CTGCACCCCC AGCCGGATTC TGGACCACAG 
GGGCGCCTCC CTGAGGATGT GCTGCTCAAA GAGCTGGAGC TGGTGCAGAA TGCCTTCTTC 
ACTGACCCCA ATGACCAGAG TGCCTGGTTT TATCACCGTT GGCTCCTAGG CCGAGCTGAC 
CCCCAGGATG CACTGCGCTG CCTGCATGTG AGCCGGGACG AGGCCTGTCT GACTGTCTCC 
TTCTCTCGGC CCCTCTTAGT GGGCTCCAGG ATGGAGATCT TGCTGCTCAT GGTTGATGAT 
TCTCCCCTGA TTGTGGAGTG GAGGACCCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCCCTCAAC GACCAGTTGC CCCAACATAC ATTTCGCGTC 
ATTTGGACAG CAGGCGATGT CCAGAAAGAA TGCGTGCTTT TAAAAGGCCG CCAGGAGGGC 
TGGTGCCGGG ACTCCACGAC AGACGAGCAG CTATTCAGGT GTGAGCTGTC AGTGGAGAAG 
TCCACAGTGC TGCAGTCTGA GCTGGAATCC TGTAAGGAGC TGCAGGAGCT GGAGCCTGAG 
AATAAATGGT GCCTGCTTAC CATCATCCTG CTGATGCGGG CACTGGACCC CCTGCTGTAT 
GAGAAGGAGA CCCTGCAGTA CTTCCAGACC CTCAAGGCCG TGGACCCCAT GCGGGCAACG 
TATCTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAATA GCGTGCTCAA GATGGAGTAT 
GCCGAGGTGC GTGTGCTGCA CCTGGCTCAC AAGGATCTGA CAGTGCTCTG CCATCTGGAA 
CAGCTGCTCT TGGTCACCCA TCTTGACTTG TCACACAATC GCCTCCGAAC CCTGCCACCT 
GCACTGGCTG CCCTGCGCTG CCTTGAGGTG CTGCAGGCCA GTGATAATGC CATAGAGTCC 
CTGGACGGCG TCACCAACCT ACCCCGGCTG CAGGAGCTGC TACTGTGCAA CAACCGCCTC 
CAGCAGCCTG CAGTGCTCCA GCCTCTTGCC TCCTGCCCCA GGCTGGTCCT CCTCAACCTG 
CAGGGTAACC CGCTGTGCCA AGCGGTGGGC ATCTTGGAGC AACTGGCTGA ACTGCTGCCT 
TCAGTTAGCA GCGTCCTCAC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004572.3
CDS	513..2216
Translation	MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVLT

Target ORF information:

RefSeq Version	NM_004581.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Rab geranylgeranyltransferase subunit alpha (RABGGTA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004581.5

ORF Insert Sequence:

ATGCACGGAC GCCTGAAGGT GAAGACGTCA GAAGAGCAGG CGGAGGCCAA AAGGCTAGAG 
CGAGAGCAGA AGCTGAAGCT ATACCAGTCA GCCACCCAGG CCGTATTCCA GAAGCGCCAG 
GCTGGTGAGC TGGATGAGTC CGTGCTGGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGCCGACGA GAGGTGCTCC AGCAGCTGGA GACTCAGAAG 
TCTCCTGAAG AGTTGGCTGC TCTGGTGAAG GCAGAACTGG GCTTCCTGGA GAGCTGCCTG 
CGGGTGAACC CCAAGTCTTA TGGTACCTGG CACCACCGAT GCTGGCTGCT AGGCCGCCTG 
CCTGAGCCCA ACTGGACCCG AGAGCTGGAG CTCTGTGCCC GTTTCCTGGA GGTGGATGAG 
CGGAACTTTC ACTGCTGGGA CTATCGGCGG TTTGTGGCCA CACAGGCAGC CGTGCCCCCT 
GCAGAAGAGC TAGCCTTCAC TGACAGCCTC ATCACCCGAA ACTTCTCCAA CTACTCTTCC 
TGGCATTACC GCTCCTGTCT CTTGCCCCAG CTGCACCCCC AGCCGGATTC TGGACCACAG 
GGGCGCCTCC CTGAGGATGT GCTGCTCAAA GAGCTGGAGC TGGTGCAGAA TGCCTTCTTC 
ACTGACCCCA ATGACCAGAG TGCCTGGTTT TATCACCGTT GGCTCCTAGG CCGAGCTGAC 
CCCCAGGATG CACTGCGCTG CCTGCATGTG AGCCGGGACG AGGCCTGTCT GACTGTCTCC 
TTCTCTCGGC CCCTCTTAGT GGGCTCCAGG ATGGAGATCT TGCTGCTCAT GGTTGATGAT 
TCTCCCCTGA TTGTGGAGTG GAGGACCCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCCCTCAAC GACCAGTTGC CCCAACATAC ATTTCGCGTC 
ATTTGGACAG CAGGCGATGT CCAGAAAGAA TGCGTGCTTT TAAAAGGCCG CCAGGAGGGC 
TGGTGCCGGG ACTCCACGAC AGACGAGCAG CTATTCAGGT GTGAGCTGTC AGTGGAGAAG 
TCCACAGTGC TGCAGTCTGA GCTGGAATCC TGTAAGGAGC TGCAGGAGCT GGAGCCTGAG 
AATAAATGGT GCCTGCTTAC CATCATCCTG CTGATGCGGG CACTGGACCC CCTGCTGTAT 
GAGAAGGAGA CCCTGCAGTA CTTCCAGACC CTCAAGGCCG TGGACCCCAT GCGGGCAACG 
TATCTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAATA GCGTGCTCAA GATGGAGTAT 
GCCGAGGTGC GTGTGCTGCA CCTGGCTCAC AAGGATCTGA CAGTGCTCTG CCATCTGGAA 
CAGCTGCTCT TGGTCACCCA TCTTGACTTG TCACACAATC GCCTCCGAAC CCTGCCACCT 
GCACTGGCTG CCCTGCGCTG CCTTGAGGTG CTGCAGGCCA GTGATAATGC CATAGAGTCC 
CTGGACGGCG TCACCAACCT ACCCCGGCTG CAGGAGCTGC TACTGTGCAA CAACCGCCTC 
CAGCAGCCTG CAGTGCTCCA GCCTCTTGCC TCCTGCCCCA GGCTGGTCCT CCTCAACCTG 
CAGGGTAACC CGCTGTGCCA AGCGGTGGGC ATCTTGGAGC AACTGGCTGA ACTGCTGCCT 
TCAGTTAGCA GCGTCCTCAC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RABGGTA ( XM_011537046.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011535348.1 Homo sapiens Rab geranylgeranyltransferase, alpha subunit (RABGGTA), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu02315
Clone ID Related Accession (Same CDS sequence)	NM_182836.2 , XM_011537046.1 , NM_004581.5
Accession Version	XM_011537046.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1704bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426003200000
Organism	Homo sapiens(Human)
Product	geranylgeranyl transferase type-2 subunit alpha isoform X1
Comment

ATGCACGGAC GCCTGAAGGT GAAGACGTCA GAAGAGCAGG CGGAGGCCAA AAGGCTAGAG 
CGAGAGCAGA AGCTGAAGCT ATACCAGTCA GCCACCCAGG CCGTATTCCA GAAGCGCCAG 
GCTGGTGAGC TGGATGAGTC CGTGCTGGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGCCGACGA GAGGTGCTCC AGCAGCTGGA GACTCAGAAG 
TCTCCTGAAG AGTTGGCTGC TCTGGTGAAG GCAGAACTGG GCTTCCTGGA GAGCTGCCTG 
CGGGTGAACC CCAAGTCTTA TGGTACCTGG CACCACCGAT GCTGGCTGCT AGGCCGCCTG 
CCTGAGCCCA ACTGGACCCG AGAGCTGGAG CTCTGTGCCC GTTTCCTGGA GGTGGATGAG 
CGGAACTTTC ACTGCTGGGA CTATCGGCGG TTTGTGGCCA CACAGGCAGC CGTGCCCCCT 
GCAGAAGAGC TAGCCTTCAC TGACAGCCTC ATCACCCGAA ACTTCTCCAA CTACTCTTCC 
TGGCATTACC GCTCCTGTCT CTTGCCCCAG CTGCACCCCC AGCCGGATTC TGGACCACAG 
GGGCGCCTCC CTGAGGATGT GCTGCTCAAA GAGCTGGAGC TGGTGCAGAA TGCCTTCTTC 
ACTGACCCCA ATGACCAGAG TGCCTGGTTT TATCACCGTT GGCTCCTAGG CCGAGCTGAC 
CCCCAGGATG CACTGCGCTG CCTGCATGTG AGCCGGGACG AGGCCTGTCT GACTGTCTCC 
TTCTCTCGGC CCCTCTTAGT GGGCTCCAGG ATGGAGATCT TGCTGCTCAT GGTTGATGAT 
TCTCCCCTGA TTGTGGAGTG GAGGACCCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCCCTCAAC GACCAGTTGC CCCAACATAC ATTTCGCGTC 
ATTTGGACAG CAGGCGATGT CCAGAAAGAA TGCGTGCTTT TAAAAGGCCG CCAGGAGGGC 
TGGTGCCGGG ACTCCACGAC AGACGAGCAG CTATTCAGGT GTGAGCTGTC AGTGGAGAAG 
TCCACAGTGC TGCAGTCTGA GCTGGAATCC TGTAAGGAGC TGCAGGAGCT GGAGCCTGAG 
AATAAATGGT GCCTGCTTAC CATCATCCTG CTGATGCGGG CACTGGACCC CCTGCTGTAT 
GAGAAGGAGA CCCTGCAGTA CTTCCAGACC CTCAAGGCCG TGGACCCCAT GCGGGCAACG 
TATCTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAATA GCGTGCTCAA GATGGAGTAT 
GCCGAGGTGC GTGTGCTGCA CCTGGCTCAC AAGGATCTGA CAGTGCTCTG CCATCTGGAA 
CAGCTGCTCT TGGTCACCCA TCTTGACTTG TCACACAATC GCCTCCGAAC CCTGCCACCT 
GCACTGGCTG CCCTGCGCTG CCTTGAGGTG CTGCAGGCCA GTGATAATGC CATAGAGTCC 
CTGGACGGCG TCACCAACCT ACCCCGGCTG CAGGAGCTGC TACTGTGCAA CAACCGCCTC 
CAGCAGCCTG CAGTGCTCCA GCCTCTTGCC TCCTGCCCCA GGCTGGTCCT CCTCAACCTG 
CAGGGTAACC CGCTGTGCCA AGCGGTGGGC ATCTTGGAGC AACTGGCTGA ACTGCTGCCT 
TCAGTTAGCA GCGTCCTCAC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011535348.1

Translation

MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVLT

Target ORF information:

RefSeq Version	XM_011537046.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens Rab geranylgeranyltransferase, alpha subunit (RABGGTA), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011537046.1

ORF Insert Sequence:

ATGCACGGAC GCCTGAAGGT GAAGACGTCA GAAGAGCAGG CGGAGGCCAA AAGGCTAGAG 
CGAGAGCAGA AGCTGAAGCT ATACCAGTCA GCCACCCAGG CCGTATTCCA GAAGCGCCAG 
GCTGGTGAGC TGGATGAGTC CGTGCTGGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGCCGACGA GAGGTGCTCC AGCAGCTGGA GACTCAGAAG 
TCTCCTGAAG AGTTGGCTGC TCTGGTGAAG GCAGAACTGG GCTTCCTGGA GAGCTGCCTG 
CGGGTGAACC CCAAGTCTTA TGGTACCTGG CACCACCGAT GCTGGCTGCT AGGCCGCCTG 
CCTGAGCCCA ACTGGACCCG AGAGCTGGAG CTCTGTGCCC GTTTCCTGGA GGTGGATGAG 
CGGAACTTTC ACTGCTGGGA CTATCGGCGG TTTGTGGCCA CACAGGCAGC CGTGCCCCCT 
GCAGAAGAGC TAGCCTTCAC TGACAGCCTC ATCACCCGAA ACTTCTCCAA CTACTCTTCC 
TGGCATTACC GCTCCTGTCT CTTGCCCCAG CTGCACCCCC AGCCGGATTC TGGACCACAG 
GGGCGCCTCC CTGAGGATGT GCTGCTCAAA GAGCTGGAGC TGGTGCAGAA TGCCTTCTTC 
ACTGACCCCA ATGACCAGAG TGCCTGGTTT TATCACCGTT GGCTCCTAGG CCGAGCTGAC 
CCCCAGGATG CACTGCGCTG CCTGCATGTG AGCCGGGACG AGGCCTGTCT GACTGTCTCC 
TTCTCTCGGC CCCTCTTAGT GGGCTCCAGG ATGGAGATCT TGCTGCTCAT GGTTGATGAT 
TCTCCCCTGA TTGTGGAGTG GAGGACCCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCCCTCAAC GACCAGTTGC CCCAACATAC ATTTCGCGTC 
ATTTGGACAG CAGGCGATGT CCAGAAAGAA TGCGTGCTTT TAAAAGGCCG CCAGGAGGGC 
TGGTGCCGGG ACTCCACGAC AGACGAGCAG CTATTCAGGT GTGAGCTGTC AGTGGAGAAG 
TCCACAGTGC TGCAGTCTGA GCTGGAATCC TGTAAGGAGC TGCAGGAGCT GGAGCCTGAG 
AATAAATGGT GCCTGCTTAC CATCATCCTG CTGATGCGGG CACTGGACCC CCTGCTGTAT 
GAGAAGGAGA CCCTGCAGTA CTTCCAGACC CTCAAGGCCG TGGACCCCAT GCGGGCAACG 
TATCTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAATA GCGTGCTCAA GATGGAGTAT 
GCCGAGGTGC GTGTGCTGCA CCTGGCTCAC AAGGATCTGA CAGTGCTCTG CCATCTGGAA 
CAGCTGCTCT TGGTCACCCA TCTTGACTTG TCACACAATC GCCTCCGAAC CCTGCCACCT 
GCACTGGCTG CCCTGCGCTG CCTTGAGGTG CTGCAGGCCA GTGATAATGC CATAGAGTCC 
CTGGACGGCG TCACCAACCT ACCCCGGCTG CAGGAGCTGC TACTGTGCAA CAACCGCCTC 
CAGCAGCCTG CAGTGCTCCA GCCTCTTGCC TCCTGCCCCA GGCTGGTCCT CCTCAACCTG 
CAGGGTAACC CGCTGTGCCA AGCGGTGGGC ATCTTGGAGC AACTGGCTGA ACTGCTGCCT 
TCAGTTAGCA GCGTCCTCAC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Comprehensive mutation analysis (20 families) of the choroideremia gene reveals a missense variant that prevents the binding of REP1 with Rab geranylgeranyl transferase.
Human mutation32(12)1460-9(2011 Dec)
Esposito G,De Falco F,Tinto N,Testa F,Vitagliano L,Tandurella IC,Iannone L,Rossi S,Rinaldi E,Simonelli F,Zagari A,Salvatore F

Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Cancer prevention research (Philadelphia, Pa.)3(5)597-603(2010 May)
Lipkin SM,Chao EC,Moreno V,Rozek LS,Rennert H,Pinchev M,Dizon D,Rennert G,Kopelovich L,Gruber SB

Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.
Proteomics4(5)1346-58(2004 May)
Hassel S,Eichner A,Yakymovych M,Hellman U,Knaus P,Souchelnytskyi S

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Molecular cell11(2)483-94(2003 Feb)
Pylypenko O,Rak A,Reents R,Niculae A,Sidorovitch V,Cioaca MD,Bessolitsyna E,Thomä NH,Waldmann H,Schlichting I,Goody RS,Alexandrov K

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RABGGTA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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