PRPS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRPS2
Entrez Gene ID	5634
Full Name	phosphoribosyl pyrophosphate synthetase 2
Synonyms	PRSII
General protein information	Preferred Names phosphoribosyl pyrophosphate synthetase 2 Names ribose-phosphate pyrophosphokinase 2 PPRibP synthetase PRS-II phosphoribosyl pyrophosphate synthase II ribose-phosphate diphosphokinase 2 testicular secretory protein Li 41
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.2
Summary	This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Disorder MIM:	311860

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039091.2	NP_001034180.1	ribose-phosphate pyrophosphokinase 2 isoform 1
NM_002765.4	NP_002756.1	ribose-phosphate pyrophosphokinase 2 isoform 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	PRPS2	NP_001006264.1
Rattus norvegicus (Norway rat)	Prps2	NP_036766.1
Kluyveromyces lactis	KLLA0F25718g	XP_456225.1
Saccharomyces cerevisiae (baker's yeast)	PRS3	NP_011852.1
Xenopus tropicalis (tropical clawed frog)	prps2	NP_001011074.1
Homo sapiens (human)	PRPS2	NP_001034180.1
Canis lupus familiaris (dog)	PRPS2	XP_005641173.1
Mus musculus (house mouse)	Prps2	NP_080938.1
Caenorhabditis elegans (roundworm)	R151.2	NP_001022728.1
Eremothecium gossypii	AGOS_AGL080C	NP_986586.1
Bos taurus (cattle)	PRPS2	NP_001107624.1

Gene Ontology
Bibliography

Related articles in PubMed

PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells.
Lei B, Wan B, Peng J, Yang Y, Lv D, Zhou X, Shu F, Li F, Zhong L, Wu H, Mao X
The Journal of urology194(5)1491-7(2015 Nov)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus.
Zhang Y, Zhang J, Yang J, Wang Y, Zhang L, Zuo X, Sun L, Pan HF, Hirankarn N, Wang T, Chen R, Ying D, Zeng S, Shen JJ, Lee TL, Lau CS, Chan TM, Leung AM, Mok CC, Wong SN, Lee KW, Ho MH, Lee PP, Chung BH, Chong CY, Wong RW, Mok MY, Wong WH, Tong KL, Tse NK, Li XP, Avihingsanon Y, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Shotelersuk V, Ying SK, Fung SK, Lai WM, Wong CM, Ng IO, Garcia-Barcelo MM, Cherny SS, Tam PK, Sham PC, Yang S, Ye DQ, Cui Y, Zhang XJ, Lau YL, Yang W
Human molecular genetics24(1)274-84(2015 Jan)

Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.
Minchenko OH, Garmash IA, Kovalevska OV, Tsymbal DO, Minchenko DO
Ukrainian biochemical journal86(6)74-83(2014 Nov-Dec)

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.
Mannava S, Grachtchouk V, Wheeler LJ, Im M, Zhuang D, Slavina EG, Mathews CK, Shewach DS, Nikiforov MA
Cell cycle (Georgetown, Tex.)7(15)2392-400(2008 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PRPS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRPS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu09342	NM_002765.4 Latest version!	Homo sapiens phosphoribosyl pyrophosphate synthetase 2 (PRPS2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
OHu19325	NM_001039091.2 Latest version!	Homo sapiens phosphoribosyl pyrophosphate synthetase 2 (PRPS2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRPS2 ( NM_002765.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002756.1 Homo sapiens phosphoribosyl pyrophosphate synthetase 2 (PRPS2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09342
Clone ID Related Accession (Same CDS sequence)	NM_002765.4
Accession Version	NM_002765.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	ribose-phosphate pyrophosphokinase 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA478574.1, BC110875.1 and BU675363.1. On Mar 5, 2010 this sequence version replaced NM_002765.3. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.331313.1, BC040483.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAACA TCGTGCTGTT CAGCGGCAGC TCGCATCAGG ACCTGTCCCA GCGCGTGGCC 
GACCGCCTGG GCCTGGAGCT GGGCAAGGTG GTCACGAAGA AGTTCAGCAA CCAGGAGACC 
AGCGTGGAGA TTGGTGAAAG CGTGAGAGGG GAAGATGTCT ACATCATCCA GAGCGGCTGC 
GGGGAAATTA ACGACAACCT GATGGAACTC CTCATCATGA TCAATGCCTG CAAGATTGCG 
TCATCATCCA GAGTAACTGC CGTGATCCCG TGTTTCCCAT ACGCCCGACA AGATAAAAAG 
GACAAGAGTC GTGCCCCAAT TTCTGCAAAA CTTGTGGCCA ATATGCTGTC GGTGGCTGGG 
GCGGATCACA TCATCACCAT GGACCTGCAT GCTTCTCAGA TACAGGGATT CTTTGATATT 
CCTGTGGATA ATTTGTATGC GGAGCCCGCA GTCCTGCAGT GGATTCGGGA AAACATTGCC 
GAGTGGAAGA ACTGTATCAT TGTTTCACCT GACGCAGGGG GAGCCAAAAG GGTTACATCA 
ATTGCAGACA GGTTGAATGT GGAATTTGCT TTGATCCACA AAGAGAGGAA GAAGGCGAAT 
GAAGTGGACC GGATGGTCCT GGTGGGCGAC GTGAAGGACC GTGTGGCCAT CCTCGTGGAT 
GACATGGCTG ACACTTGCGG CACCATCTGC CATGCTGCGG ACAAGCTGCT GTCAGCTGGA 
GCCACCAAAG TGTATGCTAT CCTTACCCAT GGGATCTTCT CTGGACCAGC TATTTCCAGA 
ATAAATAATG CCGCCTTTGA GGCTGTTGTC GTCACAAACA CAATTCCGCA AGAGGACAAA 
ATGAAACACT GCACCAAGAT TCAGGTCATT GACATTTCCA TGATCTTGGC CGAAGCAATC 
CGAAGGACAC ACAATGGGGA ATCCGTGTCC TACCTGTTCA GCCATGTCCC GCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002756.1
CDS	144..1100
Translation	MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

Target ORF information:

RefSeq Version	NM_002765.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosyl pyrophosphate synthetase 2 (PRPS2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002765.4

ORF Insert Sequence:

ATGCCCAACA TCGTGCTGTT CAGCGGCAGC TCGCATCAGG ACCTGTCCCA GCGCGTGGCC 
GACCGCCTGG GCCTGGAGCT GGGCAAGGTG GTCACGAAGA AGTTCAGCAA CCAGGAGACC 
AGCGTGGAGA TTGGTGAAAG CGTGAGAGGG GAAGATGTCT ACATCATCCA GAGCGGCTGC 
GGGGAAATTA ACGACAACCT GATGGAACTC CTCATCATGA TCAATGCCTG CAAGATTGCG 
TCATCATCCA GAGTAACTGC CGTGATCCCG TGTTTCCCAT ACGCCCGACA AGATAAAAAG 
GACAAGAGTC GTGCCCCAAT TTCTGCAAAA CTTGTGGCCA ATATGCTGTC GGTGGCTGGG 
GCGGATCACA TCATCACCAT GGACCTGCAT GCTTCTCAGA TACAGGGATT CTTTGATATT 
CCTGTGGATA ATTTGTATGC GGAGCCCGCA GTCCTGCAGT GGATTCGGGA AAACATTGCC 
GAGTGGAAGA ACTGTATCAT TGTTTCACCT GACGCAGGGG GAGCCAAAAG GGTTACATCA 
ATTGCAGACA GGTTGAATGT GGAATTTGCT TTGATCCACA AAGAGAGGAA GAAGGCGAAT 
GAAGTGGACC GGATGGTCCT GGTGGGCGAC GTGAAGGACC GTGTGGCCAT CCTCGTGGAT 
GACATGGCTG ACACTTGCGG CACCATCTGC CATGCTGCGG ACAAGCTGCT GTCAGCTGGA 
GCCACCAAAG TGTATGCTAT CCTTACCCAT GGGATCTTCT CTGGACCAGC TATTTCCAGA 
ATAAATAATG CCGCCTTTGA GGCTGTTGTC GTCACAAACA CAATTCCGCA AGAGGACAAA 
ATGAAACACT GCACCAAGAT TCAGGTCATT GACATTTCCA TGATCTTGGC CGAAGCAATC 
CGAAGGACAC ACAATGGGGA ATCCGTGTCC TACCTGTTCA GCCATGTCCC GCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRPS2 ( NM_001039091.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001034180.1 Homo sapiens phosphoribosyl pyrophosphate synthetase 2 (PRPS2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19325
Clone ID Related Accession (Same CDS sequence)	NM_001039091.2
Accession Version	NM_001039091.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	ribose-phosphate pyrophosphokinase 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA478574.1, BC119662.1, BC110875.1 and BU675363.1. This sequence is a reference standard in the RefSeqGene project. On Mar 5, 2010 this sequence version replaced NM_001039091.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005581.1, SRR1803615.108276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCCAACA TCGTGCTGTT CAGCGGCAGC TCGCATCAGG ACCTGTCCCA GCGCGTGGCC 
GACCGCCTGG GCCTGGAGCT GGGCAAGGTG GTCACGAAGA AGTTCAGCAA CCAGGAGACC 
AGCGTGGAGA TTGGTGAAAG CGTGAGAGGG GAAGATGTCT ACATCATCCA GAGCGGCTGC 
GGGGAAATTA ACGACAACCT GATGGAACTC CTCATCATGA TCAATGCCTG CAAGATTGCG 
TCATCATCCA GAGTAACTGC CGTGATCCCG TGTTTCCCAT ACGCCCGACA AGATAAAAAG 
GACAAGGTAG GAGAGAGTCG TGCCCCAATT TCTGCAAAAC TTGTGGCCAA TATGCTGTCG 
GTGGCTGGGG CGGATCACAT CATCACCATG GACCTGCATG CTTCTCAGAT ACAGGGATTC 
TTTGATATTC CTGTGGATAA TTTGTATGCG GAGCCCGCAG TCCTGCAGTG GATTCGGGAA 
AACATTGCCG AGTGGAAGAA CTGTATCATT GTTTCACCTG ACGCAGGGGG AGCCAAAAGG 
GTTACATCAA TTGCAGACAG GTTGAATGTG GAATTTGCTT TGATCCACAA AGAGAGGAAG 
AAGGCGAATG AAGTGGACCG GATGGTCCTG GTGGGCGACG TGAAGGACCG TGTGGCCATC 
CTCGTGGATG ACATGGCTGA CACTTGCGGC ACCATCTGCC ATGCTGCGGA CAAGCTGCTG 
TCAGCTGGAG CCACCAAAGT GTATGCTATC CTTACCCATG GGATCTTCTC TGGACCAGCT 
ATTTCCAGAA TAAATAATGC CGCCTTTGAG GCTGTTGTCG TCACAAACAC AATTCCGCAA 
GAGGACAAAA TGAAACACTG CACCAAGATT CAGGTCATTG ACATTTCCAT GATCTTGGCC 
GAAGCAATCC GAAGGACACA CAATGGGGAA TCCGTGTCCT ACCTGTTCAG CCATGTCCCG 
CTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034180.1
CDS	144..1109
Translation	MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKVGESRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

Target ORF information:

RefSeq Version	NM_001039091.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosyl pyrophosphate synthetase 2 (PRPS2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039091.2

ORF Insert Sequence:

ATGCCCAACA TCGTGCTGTT CAGCGGCAGC TCGCATCAGG ACCTGTCCCA GCGCGTGGCC 
GACCGCCTGG GCCTGGAGCT GGGCAAGGTG GTCACGAAGA AGTTCAGCAA CCAGGAGACC 
AGCGTGGAGA TTGGTGAAAG CGTGAGAGGG GAAGATGTCT ACATCATCCA GAGCGGCTGC 
GGGGAAATTA ACGACAACCT GATGGAACTC CTCATCATGA TCAATGCCTG CAAGATTGCG 
TCATCATCCA GAGTAACTGC CGTGATCCCG TGTTTCCCAT ACGCCCGACA AGATAAAAAG 
GACAAGGTAG GAGAGAGTCG TGCCCCAATT TCTGCAAAAC TTGTGGCCAA TATGCTGTCG 
GTGGCTGGGG CGGATCACAT CATCACCATG GACCTGCATG CTTCTCAGAT ACAGGGATTC 
TTTGATATTC CTGTGGATAA TTTGTATGCG GAGCCCGCAG TCCTGCAGTG GATTCGGGAA 
AACATTGCCG AGTGGAAGAA CTGTATCATT GTTTCACCTG ACGCAGGGGG AGCCAAAAGG 
GTTACATCAA TTGCAGACAG GTTGAATGTG GAATTTGCTT TGATCCACAA AGAGAGGAAG 
AAGGCGAATG AAGTGGACCG GATGGTCCTG GTGGGCGACG TGAAGGACCG TGTGGCCATC 
CTCGTGGATG ACATGGCTGA CACTTGCGGC ACCATCTGCC ATGCTGCGGA CAAGCTGCTG 
TCAGCTGGAG CCACCAAAGT GTATGCTATC CTTACCCATG GGATCTTCTC TGGACCAGCT 
ATTTCCAGAA TAAATAATGC CGCCTTTGAG GCTGTTGTCG TCACAAACAC AATTCCGCAA 
GAGGACAAAA TGAAACACTG CACCAAGATT CAGGTCATTG ACATTTCCAT GATCTTGGCC 
GAAGCAATCC GAAGGACACA CAATGGGGAA TCCGTGTCCT ACCTGTTCAG CCATGTCCCG 
CTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells.
The Journal of urology194(5)1491-7(2015 Nov)
Lei B,Wan B,Peng J,Yang Y,Lv D,Zhou X,Shu F,Li F,Zhong L,Wu H,Mao X

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus.
Human molecular genetics24(1)274-84(2015 Jan)
Zhang Y,Zhang J,Yang J,Wang Y,Zhang L,Zuo X,Sun L,Pan HF,Hirankarn N,Wang T,Chen R,Ying D,Zeng S,Shen JJ,Lee TL,Lau CS,Chan TM,Leung AM,Mok CC,Wong SN,Lee KW,Ho MH,Lee PP,Chung BH,Chong CY,Wong RW,Mok MY,Wong WH,Tong KL,Tse NK,Li XP,Avihingsanon Y,Rianthavorn P,Deekajorndej T,Suphapeetiporn K,Shotelersuk V,Ying SK,Fung SK,Lai WM,Wong CM,Ng IO,Garcia-Barcelo MM,Cherny SS,Tam PK,Sham PC,Yang S,Ye DQ,Cui Y,Zhang XJ,Lau YL,Yang W

Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.
Ukrainian biochemical journal86(6)74-83(2014 Nov-Dec)
Minchenko OH,Garmash IA,Kovalevska OV,Tsymbal DO,Minchenko DO

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.
Cell cycle (Georgetown, Tex.)7(15)2392-400(2008 Aug)
Mannava S,Grachtchouk V,Wheeler LJ,Im M,Zhuang D,Slavina EG,Mathews CK,Shewach DS,Nikiforov MA

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PRPS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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