RNF126 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNF126
Entrez Gene ID	55658
Full Name	ring finger protein 126
General protein information	Preferred Names ring finger protein 126 Names E3 ubiquitin-protein ligase RNF126
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008].
Disorder MIM:	615177

mRNA and Protein(s)

mRNA	Protein	Name
NM_001366018.1	NP_001352947.1	E3 ubiquitin-protein ligase RNF126 isoform 2
NM_194460.2	NP_919442.1	E3 ubiquitin-protein ligase RNF126
NM_194460.3	NP_919442.1	E3 ubiquitin-protein ligase RNF126 isoform 1
XM_005259594.1	XP_005259651.1	E3 ubiquitin-protein ligase RNF126 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	RNF126	NP_919442.1
Rattus norvegicus (Norway rat)	Rnf126	NP_001028874.1
Pan troglodytes (chimpanzee)	RNF126	XP_003953350.1
Drosophila melanogaster (fruit fly)	CG11982	NP_649859.1
Danio rerio (zebrafish)	rnf126	NP_001076486.1
Gallus gallus (chicken)	RNF126	NP_001006338.2
Xenopus tropicalis (tropical clawed frog)	rnf126	NP_001006735.1
Macaca mulatta (Rhesus monkey)	RNF126	XP_001091510.1
Canis lupus familiaris (dog)	LOC485101	XP_005633309.1
Bos taurus (cattle)	RNF126	NP_001068782.1
Mus musculus (house mouse)	Rnf126	NP_653111.1

Gene Ontology
Bibliography

Related articles in PubMed

RNF126 Quenches RNF168 Function in the DNA Damage Response.
Zhang L, Wang Z, Shi R, Zhu X, Zhou J, Peng B, Xu X
Genomics, proteomics & bioinformatics16(6)428-438(2018 12)

RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells.
Yang X, Pan Y, Qiu Z, Du Z, Zhang Y, Fa P, Gorityala S, Ma S, Li S, Chen C, Wang H, Xu Y, Yan C, Ruth K, Ma Z, Zhang J
Clinical cancer research : an official journal of the American Association for Cancer Research24(7)1629-1643(2018 04)

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia.
Benini M, Fortuni S, Condò I, Alfedi G, Malisan F, Toschi N, Serio D, Massaro DS, Arcuri G, Testi R, Rufini A
Cell reports18(8)2007-2017(2017 02)

Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair.
Ishida N, Nakagawa T, Iemura SI, Yasui A, Shima H, Katoh Y, Nagasawa Y, Natsume T, Igarashi K, Nakayama K
Molecular and cellular biology37(4)(2017 02)

E3 Ubiquitin ligase RNF126 regulates the progression of tongue cancer.
Wang L, Wang X, Zhao Y, Niu W, Ma G, Yin W, Shi C
Cancer medicine5(8)2043-7(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RNF126 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNF126 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu51696	NM_001366018.1 Latest version!	Homo sapiens ring finger protein 126 (RNF126), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu51696	XM_005259594.1 Latest version!	Homo sapiens ring finger protein 126 (RNF126), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu21918	NM_194460.3 Latest version!	Homo sapiens ring finger protein 126 (RNF126), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
View Old Accession Versions >>
OHu21918	NM_194460.2	Homo sapiens ring finger protein 126 (RNF126), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNF126 ( NM_194460.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_919442.1 Homo sapiens ring finger protein 126 (RNF126), mRNA.

Price & Availability↑

CloneID	OHu21918
Clone ID Related Accession (Same CDS sequence)	NM_194460.2 , NM_194460.3
Accession Version	NM_194460.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512403200000
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF126
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289616.1, AC004156.1, AC004449.1 and BG773910.1. This sequence is a reference standard in the RefSeqGene project. On May 28, 2010 this sequence version replaced NM_194460.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.49412.1, SRR1163658.554841.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGG CGTCGCCGCA TCCCGGACGG TACTTCTGCC ACTGCTGCTC CGTGGAGATC 
GTCCCGCGCC TGCCGGATTA TATCTGTCCA AGATGCGAGT CTGGTTTTAT CGAGGAGCTT 
CCGGAAGAGA CCAGGAGCAC AGAAAATGGT TCTGCCCCCT CCACAGCTCC CACAGACCAG 
AGCCGGCCAC CGTTGGAGCA CGTGGACCAG CACCTGTTCA CGCTGCCGCA GGGCTACGGA 
CAGTTTGCTT TCGGCATCTT CGATGACAGC TTCGAGATCC CCACGTTCCC TCCTGGGGCG 
CAGGCTGACG ACGGCAGGGA CCCTGAGAGC CGGCGGGAGA GAGACCATCC GTCCCGGCAC 
CGGTACGGCG CCCGACAGCC CCGCGCCCGC CTCACCACGC GGCGGGCCAC CGGCCGGCAC 
GAAGGCGTCC CCACGCTGGA AGGGATCATC CAGCAGCTCG TCAACGGCAT CATCACGCCC 
GCCACCATCC CCAGCCTGGG CCCCTGGGGA GTCCTGCACT CAAACCCTAT GGACTACGCC 
TGGGGGGCCA ACGGCCTGGA TGCCATCATC ACACAGCTCC TCAATCAGTT TGAAAACACA 
GGCCCCCCAC CGGCAGATAA AGAGAAAATC CAGGCCCTCC CCACCGTCCC CGTCACTGAG 
GAGCACGTAG GCTCCGGGCT CGAGTGCCCT GTGTGCAAGG ACGACTACGC GCTGGGTGAG 
CGTGTGCGGC AGCTGCCCTG CAACCACCTG TTCCACGACG GCTGCATCGT GCCCTGGCTG 
GAGCAGCACG ACAGCTGCCC CGTCTGCCGA AAAAGCCTCA CGGGACAGAA CACGGCCACG 
AACCCCCCTG GCCTCACTGG GGTGAGCTTC TCCTCCTCGT CGTCATCGTC CTCCTCCAGC 
TCGCCCAGCA ACGAGAACGC CACAAGCAAC TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919442.1
CDS	113..1048
Translation	MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS

Target ORF information:

RefSeq Version	NM_194460.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 126 (RNF126), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194460.2

ORF Insert Sequence:

ATGGCCGAGG CGTCGCCGCA TCCCGGACGG TACTTCTGCC ACTGCTGCTC CGTGGAGATC 
GTCCCGCGCC TGCCGGATTA TATCTGTCCA AGATGCGAGT CTGGTTTTAT CGAGGAGCTT 
CCGGAAGAGA CCAGGAGCAC AGAAAATGGT TCTGCCCCCT CCACAGCTCC CACAGACCAG 
AGCCGGCCAC CGTTGGAGCA CGTGGACCAG CACCTGTTCA CGCTGCCGCA GGGCTACGGA 
CAGTTTGCTT TCGGCATCTT CGATGACAGC TTCGAGATCC CCACGTTCCC TCCTGGGGCG 
CAGGCTGACG ACGGCAGGGA CCCTGAGAGC CGGCGGGAGA GAGACCATCC GTCCCGGCAC 
CGGTACGGCG CCCGACAGCC CCGCGCCCGC CTCACCACGC GGCGGGCCAC CGGCCGGCAC 
GAAGGCGTCC CCACGCTGGA AGGGATCATC CAGCAGCTCG TCAACGGCAT CATCACGCCC 
GCCACCATCC CCAGCCTGGG CCCCTGGGGA GTCCTGCACT CAAACCCTAT GGACTACGCC 
TGGGGGGCCA ACGGCCTGGA TGCCATCATC ACACAGCTCC TCAATCAGTT TGAAAACACA 
GGCCCCCCAC CGGCAGATAA AGAGAAAATC CAGGCCCTCC CCACCGTCCC CGTCACTGAG 
GAGCACGTAG GCTCCGGGCT CGAGTGCCCT GTGTGCAAGG ACGACTACGC GCTGGGTGAG 
CGTGTGCGGC AGCTGCCCTG CAACCACCTG TTCCACGACG GCTGCATCGT GCCCTGGCTG 
GAGCAGCACG ACAGCTGCCC CGTCTGCCGA AAAAGCCTCA CGGGACAGAA CACGGCCACG 
AACCCCCCTG GCCTCACTGG GGTGAGCTTC TCCTCCTCGT CGTCATCGTC CTCCTCCAGC 
TCGCCCAGCA ACGAGAACGC CACAAGCAAC TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF126 ( NM_001366018.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001352947.1 Homo sapiens ring finger protein 126 (RNF126), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu51696
Clone ID Related Accession (Same CDS sequence)	NM_001366018.1 , XM_005259594.1
Accession Version	NM_001366018.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569772800000
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF126 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004156.1 and AC004449.1. On Sep 20, 2018 this sequence version replaced XM_005259594.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.877951.1, SRR3476690.627050.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCCGAGG CGTCGCCGCA TCCCGGACGG TACTTCTGCC ACTGCTGCTC CGTGGAGATC 
GTCCCGCGCC TGCCGGATTA TATCTGTCCA AGATGCGAGT CTGGTTTTAT CGAGGAGCTT 
CCGGAAGAGA CCAGGAGCAC AGAAAATGGT TCTGCCCCCT CCACAGCTCC CACAGACCAG 
AGCCGGCCAC CGTTGGAGCA CGTGGACCAG CACCTGTTCA CGCTGCCGCA GGGCTACGGA 
CAGTTTGCTT TCGGCATCTT CGATGACAGC TTCGAGATCC CCACGTTCCC TCCTGGGGCG 
CAGGCTGACG ACGGCAGGGA CCCTGAGAGC CGGCGGGAGA GAGACCATCC GTCCCGGCAC 
CGGATCATCC AGCAGCTCGT CAACGGCATC ATCACGCCCG CCACCATCCC CAGCCTGGGC 
CCCTGGGGAG TCCTGCACTC AAACCCTATG GACTACGCCT GGGGGGCCAA CGGCCTGGAT 
GCCATCATCA CACAGCTCCT CAATCAGTTT GAAAACACAG GCCCCCCACC GGCAGATAAA 
GAGAAAATCC AGGCCCTCCC CACCGTCCCC GTCACTGAGG AGCACGTAGG CTCCGGGCTC 
GAGTGCCCTG TGTGCAAGGA CGACTACGCG CTGGGTGAGC GTGTGCGGCA GCTGCCCTGC 
AACCACCTGT TCCACGACGG CTGCATCGTG CCCTGGCTGG AGCAGCACGA CAGCTGCCCC 
GTCTGCCGAA AAAGCCTCAC GGGACAGAAC ACGGCCACGA ACCCCCCTGG CCTCACTGGG 
GTGAGCTTCT CCTCCTCGTC GTCATCGTCC TCCTCCAGCT CGCCCAGCAA CGAGAACGCC 
ACAAGCAACT CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001352947.1
CDS	94..948
Translation	MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS

Target ORF information:

RefSeq Version	NM_001366018.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 126 (RNF126), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001366018.1

ORF Insert Sequence:

ATGGCCGAGG CGTCGCCGCA TCCCGGACGG TACTTCTGCC ACTGCTGCTC CGTGGAGATC 
GTCCCGCGCC TGCCGGATTA TATCTGTCCA AGATGCGAGT CTGGTTTTAT CGAGGAGCTT 
CCGGAAGAGA CCAGGAGCAC AGAAAATGGT TCTGCCCCCT CCACAGCTCC CACAGACCAG 
AGCCGGCCAC CGTTGGAGCA CGTGGACCAG CACCTGTTCA CGCTGCCGCA GGGCTACGGA 
CAGTTTGCTT TCGGCATCTT CGATGACAGC TTCGAGATCC CCACGTTCCC TCCTGGGGCG 
CAGGCTGACG ACGGCAGGGA CCCTGAGAGC CGGCGGGAGA GAGACCATCC GTCCCGGCAC 
CGGATCATCC AGCAGCTCGT CAACGGCATC ATCACGCCCG CCACCATCCC CAGCCTGGGC 
CCCTGGGGAG TCCTGCACTC AAACCCTATG GACTACGCCT GGGGGGCCAA CGGCCTGGAT 
GCCATCATCA CACAGCTCCT CAATCAGTTT GAAAACACAG GCCCCCCACC GGCAGATAAA 
GAGAAAATCC AGGCCCTCCC CACCGTCCCC GTCACTGAGG AGCACGTAGG CTCCGGGCTC 
GAGTGCCCTG TGTGCAAGGA CGACTACGCG CTGGGTGAGC GTGTGCGGCA GCTGCCCTGC 
AACCACCTGT TCCACGACGG CTGCATCGTG CCCTGGCTGG AGCAGCACGA CAGCTGCCCC 
GTCTGCCGAA AAAGCCTCAC GGGACAGAAC ACGGCCACGA ACCCCCCTGG CCTCACTGGG 
GTGAGCTTCT CCTCCTCGTC GTCATCGTCC TCCTCCAGCT CGCCCAGCAA CGAGAACGCC 
ACAAGCAACT CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF126 ( XM_005259594.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259651.1 Homo sapiens ring finger protein 126 (RNF126), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu51696
Clone ID Related Accession (Same CDS sequence)	NM_001366018.1 , XM_005259594.1
Accession Version	XM_005259594.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF126 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGAGG CGTCGCCGCA TCCCGGACGG TACTTCTGCC ACTGCTGCTC CGTGGAGATC 
GTCCCGCGCC TGCCGGATTA TATCTGTCCA AGATGCGAGT CTGGTTTTAT CGAGGAGCTT 
CCGGAAGAGA CCAGGAGCAC AGAAAATGGT TCTGCCCCCT CCACAGCTCC CACAGACCAG 
AGCCGGCCAC CGTTGGAGCA CGTGGACCAG CACCTGTTCA CGCTGCCGCA GGGCTACGGA 
CAGTTTGCTT TCGGCATCTT CGATGACAGC TTCGAGATCC CCACGTTCCC TCCTGGGGCG 
CAGGCTGACG ACGGCAGGGA CCCTGAGAGC CGGCGGGAGA GAGACCATCC GTCCCGGCAC 
CGGATCATCC AGCAGCTCGT CAACGGCATC ATCACGCCCG CCACCATCCC CAGCCTGGGC 
CCCTGGGGAG TCCTGCACTC AAACCCTATG GACTACGCCT GGGGGGCCAA CGGCCTGGAT 
GCCATCATCA CACAGCTCCT CAATCAGTTT GAAAACACAG GCCCCCCACC GGCAGATAAA 
GAGAAAATCC AGGCCCTCCC CACCGTCCCC GTCACTGAGG AGCACGTAGG CTCCGGGCTC 
GAGTGCCCTG TGTGCAAGGA CGACTACGCG CTGGGTGAGC GTGTGCGGCA GCTGCCCTGC 
AACCACCTGT TCCACGACGG CTGCATCGTG CCCTGGCTGG AGCAGCACGA CAGCTGCCCC 
GTCTGCCGAA AAAGCCTCAC GGGACAGAAC ACGGCCACGA ACCCCCCTGG CCTCACTGGG 
GTGAGCTTCT CCTCCTCGTC GTCATCGTCC TCCTCCAGCT CGCCCAGCAA CGAGAACGCC 
ACAAGCAACT CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005259651.1
CDS	193..1047
Translation	MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS

Target ORF information:

RefSeq Version	XM_005259594.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 126 (RNF126), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259594.1

ORF Insert Sequence:

ATGGCCGAGG CGTCGCCGCA TCCCGGACGG TACTTCTGCC ACTGCTGCTC CGTGGAGATC 
GTCCCGCGCC TGCCGGATTA TATCTGTCCA AGATGCGAGT CTGGTTTTAT CGAGGAGCTT 
CCGGAAGAGA CCAGGAGCAC AGAAAATGGT TCTGCCCCCT CCACAGCTCC CACAGACCAG 
AGCCGGCCAC CGTTGGAGCA CGTGGACCAG CACCTGTTCA CGCTGCCGCA GGGCTACGGA 
CAGTTTGCTT TCGGCATCTT CGATGACAGC TTCGAGATCC CCACGTTCCC TCCTGGGGCG 
CAGGCTGACG ACGGCAGGGA CCCTGAGAGC CGGCGGGAGA GAGACCATCC GTCCCGGCAC 
CGGATCATCC AGCAGCTCGT CAACGGCATC ATCACGCCCG CCACCATCCC CAGCCTGGGC 
CCCTGGGGAG TCCTGCACTC AAACCCTATG GACTACGCCT GGGGGGCCAA CGGCCTGGAT 
GCCATCATCA CACAGCTCCT CAATCAGTTT GAAAACACAG GCCCCCCACC GGCAGATAAA 
GAGAAAATCC AGGCCCTCCC CACCGTCCCC GTCACTGAGG AGCACGTAGG CTCCGGGCTC 
GAGTGCCCTG TGTGCAAGGA CGACTACGCG CTGGGTGAGC GTGTGCGGCA GCTGCCCTGC 
AACCACCTGT TCCACGACGG CTGCATCGTG CCCTGGCTGG AGCAGCACGA CAGCTGCCCC 
GTCTGCCGAA AAAGCCTCAC GGGACAGAAC ACGGCCACGA ACCCCCCTGG CCTCACTGGG 
GTGAGCTTCT CCTCCTCGTC GTCATCGTCC TCCTCCAGCT CGCCCAGCAA CGAGAACGCC 
ACAAGCAACT CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF126 ( NM_194460.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_919442.1 Homo sapiens ring finger protein 126 (RNF126), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21918
Clone ID Related Accession (Same CDS sequence)	NM_194460.2 , NM_194460.3
Accession Version	NM_194460.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569772800000
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF126 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289616.1, AC004156.1, AC004449.1 and BG773910.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_194460.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.13180.1, SRR1163658.554841.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000292363.10/ ENSP00000292363.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGAGG CGTCGCCGCA TCCCGGACGG TACTTCTGCC ACTGCTGCTC CGTGGAGATC 
GTCCCGCGCC TGCCGGATTA TATCTGTCCA AGATGCGAGT CTGGTTTTAT CGAGGAGCTT 
CCGGAAGAGA CCAGGAGCAC AGAAAATGGT TCTGCCCCCT CCACAGCTCC CACAGACCAG 
AGCCGGCCAC CGTTGGAGCA CGTGGACCAG CACCTGTTCA CGCTGCCGCA GGGCTACGGA 
CAGTTTGCTT TCGGCATCTT CGATGACAGC TTCGAGATCC CCACGTTCCC TCCTGGGGCG 
CAGGCTGACG ACGGCAGGGA CCCTGAGAGC CGGCGGGAGA GAGACCATCC GTCCCGGCAC 
CGGTACGGCG CCCGACAGCC CCGCGCCCGC CTCACCACGC GGCGGGCCAC CGGCCGGCAC 
GAAGGCGTCC CCACGCTGGA AGGGATCATC CAGCAGCTCG TCAACGGCAT CATCACGCCC 
GCCACCATCC CCAGCCTGGG CCCCTGGGGA GTCCTGCACT CAAACCCTAT GGACTACGCC 
TGGGGGGCCA ACGGCCTGGA TGCCATCATC ACACAGCTCC TCAATCAGTT TGAAAACACA 
GGCCCCCCAC CGGCAGATAA AGAGAAAATC CAGGCCCTCC CCACCGTCCC CGTCACTGAG 
GAGCACGTAG GCTCCGGGCT CGAGTGCCCT GTGTGCAAGG ACGACTACGC GCTGGGTGAG 
CGTGTGCGGC AGCTGCCCTG CAACCACCTG TTCCACGACG GCTGCATCGT GCCCTGGCTG 
GAGCAGCACG ACAGCTGCCC CGTCTGCCGA AAAAGCCTCA CGGGACAGAA CACGGCCACG 
AACCCCCCTG GCCTCACTGG GGTGAGCTTC TCCTCCTCGT CGTCATCGTC CTCCTCCAGC 
TCGCCCAGCA ACGAGAACGC CACAAGCAAC TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919442.1
CDS	94..1029
Translation	MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS

Target ORF information:

RefSeq Version	NM_194460.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 126 (RNF126), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194460.3

ORF Insert Sequence:

ATGGCCGAGG CGTCGCCGCA TCCCGGACGG TACTTCTGCC ACTGCTGCTC CGTGGAGATC 
GTCCCGCGCC TGCCGGATTA TATCTGTCCA AGATGCGAGT CTGGTTTTAT CGAGGAGCTT 
CCGGAAGAGA CCAGGAGCAC AGAAAATGGT TCTGCCCCCT CCACAGCTCC CACAGACCAG 
AGCCGGCCAC CGTTGGAGCA CGTGGACCAG CACCTGTTCA CGCTGCCGCA GGGCTACGGA 
CAGTTTGCTT TCGGCATCTT CGATGACAGC TTCGAGATCC CCACGTTCCC TCCTGGGGCG 
CAGGCTGACG ACGGCAGGGA CCCTGAGAGC CGGCGGGAGA GAGACCATCC GTCCCGGCAC 
CGGTACGGCG CCCGACAGCC CCGCGCCCGC CTCACCACGC GGCGGGCCAC CGGCCGGCAC 
GAAGGCGTCC CCACGCTGGA AGGGATCATC CAGCAGCTCG TCAACGGCAT CATCACGCCC 
GCCACCATCC CCAGCCTGGG CCCCTGGGGA GTCCTGCACT CAAACCCTAT GGACTACGCC 
TGGGGGGCCA ACGGCCTGGA TGCCATCATC ACACAGCTCC TCAATCAGTT TGAAAACACA 
GGCCCCCCAC CGGCAGATAA AGAGAAAATC CAGGCCCTCC CCACCGTCCC CGTCACTGAG 
GAGCACGTAG GCTCCGGGCT CGAGTGCCCT GTGTGCAAGG ACGACTACGC GCTGGGTGAG 
CGTGTGCGGC AGCTGCCCTG CAACCACCTG TTCCACGACG GCTGCATCGT GCCCTGGCTG 
GAGCAGCACG ACAGCTGCCC CGTCTGCCGA AAAAGCCTCA CGGGACAGAA CACGGCCACG 
AACCCCCCTG GCCTCACTGG GGTGAGCTTC TCCTCCTCGT CGTCATCGTC CTCCTCCAGC 
TCGCCCAGCA ACGAGAACGC CACAAGCAAC TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RNF126 Quenches RNF168 Function in the DNA Damage Response.
Genomics, proteomics & bioinformatics16(6)428-438(2018 12)
Zhang L,Wang Z,Shi R,Zhu X,Zhou J,Peng B,Xu X

RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research24(7)1629-1643(2018 04)
Yang X,Pan Y,Qiu Z,Du Z,Zhang Y,Fa P,Gorityala S,Ma S,Li S,Chen C,Wang H,Xu Y,Yan C,Ruth K,Ma Z,Zhang J

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia.
Cell reports18(8)2007-2017(2017 02)
Benini M,Fortuni S,Condò I,Alfedi G,Malisan F,Toschi N,Serio D,Massaro DS,Arcuri G,Testi R,Rufini A

Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair.
Molecular and cellular biology37(4)(2017 02)
Ishida N,Nakagawa T,Iemura SI,Yasui A,Shima H,Katoh Y,Nagasawa Y,Natsume T,Igarashi K,Nakayama K

E3 Ubiquitin ligase RNF126 regulates the progression of tongue cancer.
Cancer medicine5(8)2043-7(2016 08)
Wang L,Wang X,Zhao Y,Niu W,Ma G,Yin W,Shi C

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RNF126 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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