MAML3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAML3
Entrez Gene ID	55534
Full Name	mastermind like transcriptional coactivator 3
Synonyms	CAGH3,ERDA3,GDN,MAM-2,MAM2,TNRC3
General protein information	Preferred Names mastermind like transcriptional coactivator 3 Names mastermind-like protein 3 CAG repeat containing (glia-derived nexin I alpha) CAG repeat domain expanded repeat domain, CAG/CTG 3 mam-3 mastermind-like 3 polyglutamine rich trinucleotide repeat containing 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q31.1
Disorder MIM:	608991

mRNA and Protein(s)

mRNA	Protein	Name
NM_018717.4	NP_061187.2	mastermind-like protein 3
NM_018717.5	NP_061187.3	mastermind-like protein 3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MAML3	XP_003587176.1
Mus musculus (house mouse)	Maml3	NP_001004176.2
Xenopus tropicalis (tropical clawed frog)	maml3	XP_002932092.2
Pan troglodytes (chimpanzee)	MAML3	XP_526693.2
Canis lupus familiaris (dog)	MAML3	XP_005631835.1
Macaca mulatta (Rhesus monkey)	MAML3	XP_001088303.1
Rattus norvegicus (Norway rat)	Maml3	NP_001101145.2
Homo sapiens (human)	MAML3	NP_061187.2
Gallus gallus (chicken)	MAML3	XP_420411.4
Danio rerio (zebrafish)	LOC101886283	XP_005160069.1

Gene Ontology
Bibliography

Related articles in PubMed

RBPJ and MAML3: Potential Therapeutic Targets for Small Cell Lung Cancer.
Onishi H, Ichimiya S, Yanai K, Umebayashi M, Nakamura K, Yamasaki A, Imaizumi A, Nagai S, Murahashi M, Ogata H, Morisaki T
Anticancer research38(8)4543-4547(2018 Aug)

MiR-2392 suppresses metastasis and epithelial-mesenchymal transition by targeting
Li J, Li T, Lu Y, Shen G, Guo H, Wu J, Lei C, Du F, Zhou F, Zhao X, Nie Y, Fan D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(9)3774-3786(2017 09)

PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma.
Nieuwenhuis MA, Vonk JM, Himes BE, Sarnowski C, Minelli C, Jarvis D, Bouzigon E, Nickle DC, Laviolette M, Sin D, Weiss ST, van den Berge M, Koppelman GH, Postma DS
Allergy72(5)792-801(2017 May)

Protein-bound Polysaccharide-K Inhibits Hedgehog Signaling Through Down-regulation of MAML3 and RBPJ Transcription Under Hypoxia, Suppressing the Malignant Phenotype in Pancreatic Cancer.
Yamasaki A, Onishi H, Imaizumi A, Kawamoto M, Fujimura A, Oyama Y, Katano M
Anticancer research36(8)3945-52(2016 Aug)

Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma.
Heynen GJ, Nevedomskaya E, Palit S, Jagalur Basheer N, Lieftink C, Schlicker A, Zwart W, Bernards R, Bajpe PK
Molecular cancer research : MCR14(5)411-22(2016 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAML3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAML3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu02847	NM_018717.4 Latest version!	Homo sapiens mastermind like transcriptional coactivator 3 (MAML3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
OHu107587	NM_018717.5 Latest version!	Homo sapiens mastermind like transcriptional coactivator 3 (MAML3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

ORF Online Only Promotion

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2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAML3 ( NM_018717.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_061187.2 Homo sapiens mastermind like transcriptional coactivator 3 (MAML3), mRNA.

Price & Availability↑

CloneID	OHu02847
Clone ID Related Accession (Same CDS sequence)	NM_018717.4
Accession Version	NM_018717.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512835200000
Organism	Homo sapiens(human)
Product	mastermind-like protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA408716.1, AA236382.1, DN999776.1, AK123604.1, AC097464.3, BX506733.1, AL359614.1 and AC108053.3. On Nov 15, 2007 this sequence version replaced NM_018717.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.279450.1, SRR1660807.91744.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGATT TCGCAGCCCC CGCTGCTGCC GCGAATGGCA GTAGTATTTG CATCAACAGT 
AGCCTGAACA GCAGCCTCGG CGGGGCCGGG ATCGGTGTGA ATAATACTCC CAATAGTACT 
CCCGCTGCTC CGAGTAGCAA TCACCCGGCA GCCGGTGGAT GCGGCGGCTC CGGGGGCCCC 
GGCGGCGGTT CGGCGGCCGT TCCCAAGCAC AGCACCGTGG TGGAGCGGCT CCGCCAGCGC 
ATCGAGGGCT GCCGTCGGCA CCACGTCAAC TGCGAGAACA GGTACCAGCA GGCTCAGGTG 
GAGCAGCTGG AGCTGGAGCG CCGGGACACC GTGAGCCTCT ACCAGCGGAC CCTGGAGCAG 
AGGGCCAAGA AATCGGGCGC CGGCACCGGC AAACAGCAGC ACCCGAGCAA ACCCCAGCAA 
GATGCGGAGG CTGCCTCGGC GGAGCAGAGG AACCACACGC TGATCATGCT ACAAGAGACT 
GTGAAAAGGA AGTTGGAAGG AGCTCGATCA CCACTTAATG GAGACCAGCA GAATGGTGCT 
TGTGATGGGA ATTTTTCTCC GACTAGCAAA CGAATTCGAA AGGACATTTC TGCGGGGATG 
GAAGCCATCA ACAATTTGCC CAGTAACATG CCACTGCCTT CAGCTTCTCC TCTTCACCAA 
CTTGACCTGA AACCTTCTTT GCCCTTGCAG AACAGTGGAA CTCACACTCC TGGGCTTCTA 
GAAGATCTAA GTAAGAATGG TAGGCTCCCT GAGATTAAAC TTCCTGTCAA CGGTTGCAGT 
GACCTGGAGG ATAGCTTCAC CATCTTGCAG AGCAAAGACC TCAAACAAGA ACCTCTCGAT 
GACCCTACTT GCATAGACAC ATCAGAAACA TCTCTTTCAA ATCAGAACAA GCTGTTCTCA 
GACATTAATC TGAATGATCA GGAGTGGCAA GAATTAATAG ATGAATTGGC CAACACGGTT 
CCTGAGGATG ACATACAGGA CCTGTTCAAC GAAGACTTTG AAGAGAAGAA GGAGCCAGAA 
TTCTCGCAGC CAGCAACTGA GACCCCTCTC TCCCAGGAGA GTGCGAGCGT GAAGAGCGAC 
CCCTCTCACT CTCCCTTCGC ACATGTCTCC ATGGGATCTC CCCAGGCGAG GCCTTCTTCT 
TCTGGTCCTC CCTTTTCTAC TGTCTCCACG GCCACTAGTT TACCTTCTGT TGCCAGCACT 
CCCGCAGCTC CAAACCCTGC AAGCTCACCA GCAAACTGTG CTGTCCAGTC CCCTCAAACT 
CCAAACCAAG CCCACACTCC AGGCCAAGCT CCACCTCGGC CTGGAAATGG TTATCTCCTG 
AATCCGGCAG CAGTGACAGT GGCCGGTTCA GCGTCAGGGC CTGTGGCTGT GCCCAGCTCT 
GACATGTCTC CAGCAGAACA GCTCAAACAG ATGGCTGCAC AGCAGCAACA AAGGGCCAAA 
CTCATGCAGC AGAAACAGCA ACAGCAACAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAACAGCA CTCAAATCAG ACTTCAAATT GGTCTCCCTT AGGACCTCCC 
TCTAGTCCAT ATGGAGCAGC TTTTACTGCA GAAAAACCAA ATAGCCCAAT GATGTACCCC 
CAAGCCTTTA ACAACCAAAA CCCTATAGTG CCTCCAATGG CAAACAACCT GCAGAAGACA 
ACAATGAATA ACTACCTCCC TCAGAATCAC ATGAATATGA TCAATCAGCA GCCAAATAAC 
TTGGGTACAA ACTCCTTAAA CAAACAGCAC AATATTCTGA CTTATGGCAA CACTAAACCC 
CTGACCCACT TCAATGCAGA CCTGAGTCAG AGGATGACAC CACCAGTGGC CAACCCCAAC 
AAAAACCCCT TGATGCCGTA TATCCAGCAG CAGCAACAGC AGCAGCAACA GCAACAGCAG 
CAGCAGCAGC AGCAGCAGCC GCCACCTCCA CAGCTCCAGG CCCCCAGGGC ACACCTGAGC 
GAAGACCAGA AACGCCTGCT TCTCATGAAG CAGAAAGGAG TGATGAATCA GCCCATGGCT 
TACGCTGCAC TTCCATCCCA CGGTCAGGAG CAGCATCCAG TTGGACTTCC CCGAACCACA 
GGCCCCATGC AGTCCTCCGT GCCCCCAGGC TCAGGTGGCA TGGTCTCAGG AGCCAGTCCC 
GCAGGCCCCG GCTTCCTGGG CAGCCAGCCC CAAGCAGCCA TCATGAAGCA GATGCTCATT 
GATCAGCGGG CCCAGTTGAT AGAGCAGCAG AAGCAACAGT TCCTGCGGGA GCAAAGGCAG 
CAGCAGCAGC AGCAGCAGCA GATTTTGGCG GAACAGCAGT TGCAGCAATC ACATCTACCC 
CGGCAGCACC TCCAGCCACA GCGGAATCCA TACCCAGTGC AGCAGGTCAA TCAGTTTCAA 
GGTTCTCCCC AGGATATAGC AGCCGTAAGA AGCCAAGCAG CCCTCCAGAG CATGCGAACG 
TCACGGCTGA TGGCACAGAA CGCAGGCATG ATGGGAATAG GACCCTCCCA GAACCCTGGG 
ACGATGGCCA CCGCAGCTGC GCAGTCGGAG ATGGGACTGG CCCCTTATAG CACCACGCCT 
ACCAGCCAAC CAGGAATGTA CAATATGAGC ACAGGCATGA CCCAAATGTT GCAGCATCCA 
AACCAAAGTG GCATGAGCAT CACACATAAC CAAGCCCAGG GACCGAGGCA ACCTGCCTCT 
GGGCAGGGGG TTGGAATGGT GAGTGGCTTT GGTCAGAGCA TGCTGGTGAA CTCAGCCATT 
ACCCAGCAAC ATCCACAGAT GAAAGGGCCA GTAGGCCAGG CCTTGCCTAG GCCCCAAGCC 
CCTCCAAGGC TGCAGAGCCT TATGGGAACA GTCCAGCAAG GAGCACAAAG CTGGCAACAG 
AGGAGCTTGC AGGGCATGCC TGGGAGGACT AGTGGAGAAT TGGGACCATT CAACAATGGC 
GCCAGCTACC CTCTTCAAGC TGGGCAGCCG AGACTGACCA AGCAGCACTT CCCACAGGGA 
CTGAGCCAGT CAGTCGTGGA TGCTAACACG GGCACAGTGA GGACCCTCAA CCCAGCTGCC 
ATGGGTCGGC AGATGATGCC ATCGCTCCCG GGGCAGCAAG GCACCAGCCA GGCGAGGCCA 
ATGGTCATGT CTGGCCTGAG CCAGGGAGTC CCAGGCATGC CAGCGTTCAG CCAGCCCCCA 
GCACAGCAGC AGATACCCAG TGGCAGCTTT GCTCCAAGCA GCCAGAGCCA AGCCTATGAG 
CGGAATGCCC CTCAGGACGT GTCATACAAT TACAGTGGCG ACGGAGCTGG GGGTTCCTTC 
CCTGGCCTCC CGGACGGTGC AGACCTTGTG GACTCCATCA TCAAAGGCGG GCCAGGGGAC 
GAGTGGATGC AGGAGCTTGA TGAATTGTTT GGTAACCCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061187.2
CDS	753..4154
Translation	MGDFAAPAAAANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGPGGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQRAKKSGAGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP

Target ORF information:

RefSeq Version	NM_018717.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mastermind like transcriptional coactivator 3 (MAML3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018717.4

ORF Insert Sequence:

ATGGGGGATT TCGCAGCCCC CGCTGCTGCC GCGAATGGCA GTAGTATTTG CATCAACAGT 
AGCCTGAACA GCAGCCTCGG CGGGGCCGGG ATCGGTGTGA ATAATACTCC CAATAGTACT 
CCCGCTGCTC CGAGTAGCAA TCACCCGGCA GCCGGTGGAT GCGGCGGCTC CGGGGGCCCC 
GGCGGCGGTT CGGCGGCCGT TCCCAAGCAC AGCACCGTGG TGGAGCGGCT CCGCCAGCGC 
ATCGAGGGCT GCCGTCGGCA CCACGTCAAC TGCGAGAACA GGTACCAGCA GGCTCAGGTG 
GAGCAGCTGG AGCTGGAGCG CCGGGACACC GTGAGCCTCT ACCAGCGGAC CCTGGAGCAG 
AGGGCCAAGA AATCGGGCGC CGGCACCGGC AAACAGCAGC ACCCGAGCAA ACCCCAGCAA 
GATGCGGAGG CTGCCTCGGC GGAGCAGAGG AACCACACGC TGATCATGCT ACAAGAGACT 
GTGAAAAGGA AGTTGGAAGG AGCTCGATCA CCACTTAATG GAGACCAGCA GAATGGTGCT 
TGTGATGGGA ATTTTTCTCC GACTAGCAAA CGAATTCGAA AGGACATTTC TGCGGGGATG 
GAAGCCATCA ACAATTTGCC CAGTAACATG CCACTGCCTT CAGCTTCTCC TCTTCACCAA 
CTTGACCTGA AACCTTCTTT GCCCTTGCAG AACAGTGGAA CTCACACTCC TGGGCTTCTA 
GAAGATCTAA GTAAGAATGG TAGGCTCCCT GAGATTAAAC TTCCTGTCAA CGGTTGCAGT 
GACCTGGAGG ATAGCTTCAC CATCTTGCAG AGCAAAGACC TCAAACAAGA ACCTCTCGAT 
GACCCTACTT GCATAGACAC ATCAGAAACA TCTCTTTCAA ATCAGAACAA GCTGTTCTCA 
GACATTAATC TGAATGATCA GGAGTGGCAA GAATTAATAG ATGAATTGGC CAACACGGTT 
CCTGAGGATG ACATACAGGA CCTGTTCAAC GAAGACTTTG AAGAGAAGAA GGAGCCAGAA 
TTCTCGCAGC CAGCAACTGA GACCCCTCTC TCCCAGGAGA GTGCGAGCGT GAAGAGCGAC 
CCCTCTCACT CTCCCTTCGC ACATGTCTCC ATGGGATCTC CCCAGGCGAG GCCTTCTTCT 
TCTGGTCCTC CCTTTTCTAC TGTCTCCACG GCCACTAGTT TACCTTCTGT TGCCAGCACT 
CCCGCAGCTC CAAACCCTGC AAGCTCACCA GCAAACTGTG CTGTCCAGTC CCCTCAAACT 
CCAAACCAAG CCCACACTCC AGGCCAAGCT CCACCTCGGC CTGGAAATGG TTATCTCCTG 
AATCCGGCAG CAGTGACAGT GGCCGGTTCA GCGTCAGGGC CTGTGGCTGT GCCCAGCTCT 
GACATGTCTC CAGCAGAACA GCTCAAACAG ATGGCTGCAC AGCAGCAACA AAGGGCCAAA 
CTCATGCAGC AGAAACAGCA ACAGCAACAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAACAGCA CTCAAATCAG ACTTCAAATT GGTCTCCCTT AGGACCTCCC 
TCTAGTCCAT ATGGAGCAGC TTTTACTGCA GAAAAACCAA ATAGCCCAAT GATGTACCCC 
CAAGCCTTTA ACAACCAAAA CCCTATAGTG CCTCCAATGG CAAACAACCT GCAGAAGACA 
ACAATGAATA ACTACCTCCC TCAGAATCAC ATGAATATGA TCAATCAGCA GCCAAATAAC 
TTGGGTACAA ACTCCTTAAA CAAACAGCAC AATATTCTGA CTTATGGCAA CACTAAACCC 
CTGACCCACT TCAATGCAGA CCTGAGTCAG AGGATGACAC CACCAGTGGC CAACCCCAAC 
AAAAACCCCT TGATGCCGTA TATCCAGCAG CAGCAACAGC AGCAGCAACA GCAACAGCAG 
CAGCAGCAGC AGCAGCAGCC GCCACCTCCA CAGCTCCAGG CCCCCAGGGC ACACCTGAGC 
GAAGACCAGA AACGCCTGCT TCTCATGAAG CAGAAAGGAG TGATGAATCA GCCCATGGCT 
TACGCTGCAC TTCCATCCCA CGGTCAGGAG CAGCATCCAG TTGGACTTCC CCGAACCACA 
GGCCCCATGC AGTCCTCCGT GCCCCCAGGC TCAGGTGGCA TGGTCTCAGG AGCCAGTCCC 
GCAGGCCCCG GCTTCCTGGG CAGCCAGCCC CAAGCAGCCA TCATGAAGCA GATGCTCATT 
GATCAGCGGG CCCAGTTGAT AGAGCAGCAG AAGCAACAGT TCCTGCGGGA GCAAAGGCAG 
CAGCAGCAGC AGCAGCAGCA GATTTTGGCG GAACAGCAGT TGCAGCAATC ACATCTACCC 
CGGCAGCACC TCCAGCCACA GCGGAATCCA TACCCAGTGC AGCAGGTCAA TCAGTTTCAA 
GGTTCTCCCC AGGATATAGC AGCCGTAAGA AGCCAAGCAG CCCTCCAGAG CATGCGAACG 
TCACGGCTGA TGGCACAGAA CGCAGGCATG ATGGGAATAG GACCCTCCCA GAACCCTGGG 
ACGATGGCCA CCGCAGCTGC GCAGTCGGAG ATGGGACTGG CCCCTTATAG CACCACGCCT 
ACCAGCCAAC CAGGAATGTA CAATATGAGC ACAGGCATGA CCCAAATGTT GCAGCATCCA 
AACCAAAGTG GCATGAGCAT CACACATAAC CAAGCCCAGG GACCGAGGCA ACCTGCCTCT 
GGGCAGGGGG TTGGAATGGT GAGTGGCTTT GGTCAGAGCA TGCTGGTGAA CTCAGCCATT 
ACCCAGCAAC ATCCACAGAT GAAAGGGCCA GTAGGCCAGG CCTTGCCTAG GCCCCAAGCC 
CCTCCAAGGC TGCAGAGCCT TATGGGAACA GTCCAGCAAG GAGCACAAAG CTGGCAACAG 
AGGAGCTTGC AGGGCATGCC TGGGAGGACT AGTGGAGAAT TGGGACCATT CAACAATGGC 
GCCAGCTACC CTCTTCAAGC TGGGCAGCCG AGACTGACCA AGCAGCACTT CCCACAGGGA 
CTGAGCCAGT CAGTCGTGGA TGCTAACACG GGCACAGTGA GGACCCTCAA CCCAGCTGCC 
ATGGGTCGGC AGATGATGCC ATCGCTCCCG GGGCAGCAAG GCACCAGCCA GGCGAGGCCA 
ATGGTCATGT CTGGCCTGAG CCAGGGAGTC CCAGGCATGC CAGCGTTCAG CCAGCCCCCA 
GCACAGCAGC AGATACCCAG TGGCAGCTTT GCTCCAAGCA GCCAGAGCCA AGCCTATGAG 
CGGAATGCCC CTCAGGACGT GTCATACAAT TACAGTGGCG ACGGAGCTGG GGGTTCCTTC 
CCTGGCCTCC CGGACGGTGC AGACCTTGTG GACTCCATCA TCAAAGGCGG GCCAGGGGAC 
GAGTGGATGC AGGAGCTTGA TGAATTGTTT GGTAACCCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAML3 ( NM_018717.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_061187.3 Homo sapiens mastermind like transcriptional coactivator 3 (MAML3), mRNA.

Price & Availability↑

CloneID	OHu107587
Clone ID Related Accession (Same CDS sequence)	NM_018717.5
Accession Version	NM_018717.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565020800000
Organism	Homo sapiens(human)
Product	mastermind-like protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC131182.3, AC097464.3 and AC108053.3. On May 30, 2018 this sequence version replaced NM_018717.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: The coding region was updated to make it identical to the current human reference genome sequence. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.279450.1, SRR1660807.91744.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000509479.6/ ENSP00000421180.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGATT TCGCAGCCCC CGCTGCTGCC GCGAATGGCA GTAGTATTTG CATCAACAGT 
AGCCTGAACA GCAGCCTCGG CGGGGCCGGG ATCGGTGTGA ATAATACTCC CAATAGTACT 
CCCGCTGCTC CGAGTAGCAA TCACCCGGCA GCCGGTGGAT GCGGCGGCTC CGGGGGCCCC 
GGCGGCGGTT CGGCGGCCGT TCCCAAGCAC AGCACCGTGG TGGAGCGGCT CCGCCAGCGC 
ATCGAGGGCT GCCGTCGGCA CCACGTCAAC TGCGAGAACA GGTACCAGCA GGCTCAGGTG 
GAGCAGCTGG AGCTGGAGCG CCGGGACACC GTGAGCCTCT ACCAGCGGAC CCTGGAGCAG 
AGGGCCAAGA AATCGGGCGC CGGCACCGGC AAACAGCAGC ACCCGAGCAA ACCCCAGCAA 
GATGCGGAGG CTGCCTCGGC GGAGCAGAGG AACCACACGC TGATCATGCT ACAAGAGACT 
GTGAAAAGGA AGTTGGAAGG AGCTCGATCA CCACTTAATG GAGACCAGCA GAATGGTGCT 
TGTGATGGGA ATTTTTCTCC GACTAGCAAA CGAATTCGAA AGGACATTTC TGCGGGGATG 
GAAGCCATCA ACAATTTGCC CAGTAACATG CCACTGCCTT CAGCTTCTCC TCTTCACCAA 
CTTGACCTGA AACCTTCTTT GCCCTTGCAG AACAGTGGAA CTCACACTCC TGGGCTTCTA 
GAAGATCTAA GTAAGAATGG TAGGCTCCCT GAGATTAAAC TTCCTGTCAA CGGTTGCAGT 
GACCTGGAGG ATAGCTTCAC CATCTTGCAG AGCAAAGACC TCAAACAAGA ACCTCTCGAT 
GACCCTACTT GCATAGACAC ATCAGAAACA TCTCTTTCAA ATCAGAACAA GCTGTTCTCA 
GACATTAATC TGAATGATCA GGAGTGGCAA GAATTAATAG ATGAATTGGC CAACACGGTT 
CCTGAGGATG ACATACAGGA CCTGTTCAAC GAAGACTTTG AAGAGAAGAA GGAGCCAGAA 
TTCTCGCAGC CAGCAACTGA GACCCCTCTC TCCCAGGAGA GTGCGAGCGT GAAGAGCGAC 
CCCTCTCACT CTCCCTTCGC ACATGTCTCC ATGGGATCTC CCCAGGCGAG GCCTTCTTCT 
TCTGGTCCTC CCTTTTCTAC TGTCTCCACG GCCACTAGTT TACCTTCTGT TGCCAGCACT 
CCCGCAGCTC CAAACCCTGC AAGCTCACCA GCAAACTGTG CTGTCCAGTC CCCTCAAACT 
CCAAACCAAG CCCACACTCC AGGCCAAGCT CCACCTCGGC CTGGAAATGG TTATCTCCTG 
AATCCGGCAG CAGTGACAGT GGCCGGTTCA GCGTCAGGGC CTGTGGCTGT GCCCAGCTCT 
GACATGTCTC CAGCAGAACA GCTCAAACAG ATGGCTGCAC AGCAGCAACA AAGGGCCAAA 
CTCATGCAGC AGAAACAGCA ACAGCAACAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAGCAGCA GCAGCAACAG CACTCAAATC AGACTTCAAA TTGGTCTCCC 
TTAGGACCTC CCTCTAGTCC ATATGGAGCA GCTTTTACTG CAGAAAAACC AAATAGCCCA 
ATGATGTACC CCCAAGCCTT TAACAACCAA AACCCTATAG TGCCTCCAAT GGCAAACAAC 
CTGCAGAAGA CAACAATGAA TAACTACCTC CCTCAGAATC ACATGAATAT GATCAATCAG 
CAGCCAAATA ACTTGGGTAC AAACTCCTTA AACAAACAGC ACAATATTCT GACTTATGGC 
AACACTAAAC CCCTGACCCA CTTCAATGCA GACCTGAGTC AGAGGATGAC ACCACCAGTG 
GCCAACCCCA ACAAAAACCC CTTGATGCCG TATATCCAGC AGCAGCAACA GCAGCAGCAA 
CAGCAACAGC AGCAGCAGCA GCAGCAGCAG CCGCCACCTC CACAGCTCCA GGCCCCCAGG 
GCACACCTGA GCGAAGACCA GAAACGCCTG CTTCTCATGA AGCAGAAAGG AGTGATGAAT 
CAGCCCATGG CTTACGCTGC ACTTCCATCC CACGGTCAGG AGCAGCATCC AGTTGGACTT 
CCCCGAACCA CAGGCCCCAT GCAGTCCTCC GTGCCCCCAG GCTCAGGTGG CATGGTCTCA 
GGAGCCAGTC CCGCAGGCCC CGGCTTCCTG GGCAGCCAGC CCCAAGCAGC CATCATGAAG 
CAGATGCTCA TTGATCAGCG GGCCCAGTTG ATAGAGCAGC AGAAGCAACA GTTCCTGCGG 
GAGCAAAGGC AGCAGCAGCA GCAGCAGCAG CAGCAGATTT TGGCGGAACA GCAGTTGCAG 
CAATCACATC TACCCCGGCA GCACCTCCAG CCACAGCGGA ATCCATACCC AGTGCAGCAG 
GTCAATCAGT TTCAAGGTTC TCCCCAGGAT ATAGCAGCCG TAAGAAGCCA AGCAGCCCTC 
CAGAGCATGC GAACGTCACG GCTGATGGCA CAGAACGCAG GCATGATGGG AATAGGACCC 
TCCCAGAACC CTGGGACGAT GGCCACCGCA GCTGCGCAGT CGGAGATGGG ACTGGCCCCT 
TATAGCACCA CGCCTACCAG CCAACCAGGA ATGTACAATA TGAGCACAGG CATGACCCAA 
ATGTTGCAGC ATCCAAACCA AAGTGGCATG AGCATCACAC ATAACCAAGC CCAGGGACCG 
AGGCAACCTG CCTCTGGGCA GGGGGTTGGA ATGGTGAGTG GCTTTGGTCA GAGCATGCTG 
GTGAACTCAG CCATTACCCA GCAACATCCA CAGATGAAAG GGCCAGTAGG CCAGGCCTTG 
CCTAGGCCCC AAGCCCCTCC AAGGCTGCAG AGCCTTATGG GAACAGTCCA GCAAGGAGCA 
CAAAGCTGGC AACAGAGGAG CTTGCAGGGC ATGCCTGGGA GGACTAGTGG AGAATTGGGA 
CCATTCAACA ATGGCGCCAG CTACCCTCTT CAAGCTGGGC AGCCGAGACT GACCAAGCAG 
CACTTCCCAC AGGGACTGAG CCAGTCAGTC GTGGATGCTA ACACGGGCAC AGTGAGGACC 
CTCAACCCAG CTGCCATGGG TCGGCAGATG ATGCCATCGC TCCCGGGGCA GCAAGGCACC 
AGCCAGGCGA GGCCAATGGT CATGTCTGGC CTGAGCCAGG GAGTCCCAGG CATGCCAGCG 
TTCAGCCAGC CCCCAGCACA GCAGCAGATA CCCAGTGGCA GCTTTGCTCC AAGCAGCCAG 
AGCCAAGCCT ATGAGCGGAA TGCCCCTCAG GACGTGTCAT ACAATTACAG TGGCGACGGA 
GCTGGGGGTT CCTTCCCTGG CCTCCCGGAC GGTGCAGACC TTGTGGACTC CATCATCAAA 
GGCGGGCCAG GGGACGAGTG GATGCAGGAG CTTGATGAAT TGTTTGGTAA CCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061187.3
CDS	858..4274
Translation	MGDFAAPAAAANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGPGGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQRAKKSGAGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP

Target ORF information:

RefSeq Version	NM_018717.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mastermind like transcriptional coactivator 3 (MAML3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018717.5

ORF Insert Sequence:

ATGGGGGATT TCGCAGCCCC CGCTGCTGCC GCGAATGGCA GTAGTATTTG CATCAACAGT 
AGCCTGAACA GCAGCCTCGG CGGGGCCGGG ATCGGTGTGA ATAATACTCC CAATAGTACT 
CCCGCTGCTC CGAGTAGCAA TCACCCGGCA GCCGGTGGAT GCGGCGGCTC CGGGGGCCCC 
GGCGGCGGTT CGGCGGCCGT TCCCAAGCAC AGCACCGTGG TGGAGCGGCT CCGCCAGCGC 
ATCGAGGGCT GCCGTCGGCA CCACGTCAAC TGCGAGAACA GGTACCAGCA GGCTCAGGTG 
GAGCAGCTGG AGCTGGAGCG CCGGGACACC GTGAGCCTCT ACCAGCGGAC CCTGGAGCAG 
AGGGCCAAGA AATCGGGCGC CGGCACCGGC AAACAGCAGC ACCCGAGCAA ACCCCAGCAA 
GATGCGGAGG CTGCCTCGGC GGAGCAGAGG AACCACACGC TGATCATGCT ACAAGAGACT 
GTGAAAAGGA AGTTGGAAGG AGCTCGATCA CCACTTAATG GAGACCAGCA GAATGGTGCT 
TGTGATGGGA ATTTTTCTCC GACTAGCAAA CGAATTCGAA AGGACATTTC TGCGGGGATG 
GAAGCCATCA ACAATTTGCC CAGTAACATG CCACTGCCTT CAGCTTCTCC TCTTCACCAA 
CTTGACCTGA AACCTTCTTT GCCCTTGCAG AACAGTGGAA CTCACACTCC TGGGCTTCTA 
GAAGATCTAA GTAAGAATGG TAGGCTCCCT GAGATTAAAC TTCCTGTCAA CGGTTGCAGT 
GACCTGGAGG ATAGCTTCAC CATCTTGCAG AGCAAAGACC TCAAACAAGA ACCTCTCGAT 
GACCCTACTT GCATAGACAC ATCAGAAACA TCTCTTTCAA ATCAGAACAA GCTGTTCTCA 
GACATTAATC TGAATGATCA GGAGTGGCAA GAATTAATAG ATGAATTGGC CAACACGGTT 
CCTGAGGATG ACATACAGGA CCTGTTCAAC GAAGACTTTG AAGAGAAGAA GGAGCCAGAA 
TTCTCGCAGC CAGCAACTGA GACCCCTCTC TCCCAGGAGA GTGCGAGCGT GAAGAGCGAC 
CCCTCTCACT CTCCCTTCGC ACATGTCTCC ATGGGATCTC CCCAGGCGAG GCCTTCTTCT 
TCTGGTCCTC CCTTTTCTAC TGTCTCCACG GCCACTAGTT TACCTTCTGT TGCCAGCACT 
CCCGCAGCTC CAAACCCTGC AAGCTCACCA GCAAACTGTG CTGTCCAGTC CCCTCAAACT 
CCAAACCAAG CCCACACTCC AGGCCAAGCT CCACCTCGGC CTGGAAATGG TTATCTCCTG 
AATCCGGCAG CAGTGACAGT GGCCGGTTCA GCGTCAGGGC CTGTGGCTGT GCCCAGCTCT 
GACATGTCTC CAGCAGAACA GCTCAAACAG ATGGCTGCAC AGCAGCAACA AAGGGCCAAA 
CTCATGCAGC AGAAACAGCA ACAGCAACAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAGCAGCA GCAGCAACAG CACTCAAATC AGACTTCAAA TTGGTCTCCC 
TTAGGACCTC CCTCTAGTCC ATATGGAGCA GCTTTTACTG CAGAAAAACC AAATAGCCCA 
ATGATGTACC CCCAAGCCTT TAACAACCAA AACCCTATAG TGCCTCCAAT GGCAAACAAC 
CTGCAGAAGA CAACAATGAA TAACTACCTC CCTCAGAATC ACATGAATAT GATCAATCAG 
CAGCCAAATA ACTTGGGTAC AAACTCCTTA AACAAACAGC ACAATATTCT GACTTATGGC 
AACACTAAAC CCCTGACCCA CTTCAATGCA GACCTGAGTC AGAGGATGAC ACCACCAGTG 
GCCAACCCCA ACAAAAACCC CTTGATGCCG TATATCCAGC AGCAGCAACA GCAGCAGCAA 
CAGCAACAGC AGCAGCAGCA GCAGCAGCAG CCGCCACCTC CACAGCTCCA GGCCCCCAGG 
GCACACCTGA GCGAAGACCA GAAACGCCTG CTTCTCATGA AGCAGAAAGG AGTGATGAAT 
CAGCCCATGG CTTACGCTGC ACTTCCATCC CACGGTCAGG AGCAGCATCC AGTTGGACTT 
CCCCGAACCA CAGGCCCCAT GCAGTCCTCC GTGCCCCCAG GCTCAGGTGG CATGGTCTCA 
GGAGCCAGTC CCGCAGGCCC CGGCTTCCTG GGCAGCCAGC CCCAAGCAGC CATCATGAAG 
CAGATGCTCA TTGATCAGCG GGCCCAGTTG ATAGAGCAGC AGAAGCAACA GTTCCTGCGG 
GAGCAAAGGC AGCAGCAGCA GCAGCAGCAG CAGCAGATTT TGGCGGAACA GCAGTTGCAG 
CAATCACATC TACCCCGGCA GCACCTCCAG CCACAGCGGA ATCCATACCC AGTGCAGCAG 
GTCAATCAGT TTCAAGGTTC TCCCCAGGAT ATAGCAGCCG TAAGAAGCCA AGCAGCCCTC 
CAGAGCATGC GAACGTCACG GCTGATGGCA CAGAACGCAG GCATGATGGG AATAGGACCC 
TCCCAGAACC CTGGGACGAT GGCCACCGCA GCTGCGCAGT CGGAGATGGG ACTGGCCCCT 
TATAGCACCA CGCCTACCAG CCAACCAGGA ATGTACAATA TGAGCACAGG CATGACCCAA 
ATGTTGCAGC ATCCAAACCA AAGTGGCATG AGCATCACAC ATAACCAAGC CCAGGGACCG 
AGGCAACCTG CCTCTGGGCA GGGGGTTGGA ATGGTGAGTG GCTTTGGTCA GAGCATGCTG 
GTGAACTCAG CCATTACCCA GCAACATCCA CAGATGAAAG GGCCAGTAGG CCAGGCCTTG 
CCTAGGCCCC AAGCCCCTCC AAGGCTGCAG AGCCTTATGG GAACAGTCCA GCAAGGAGCA 
CAAAGCTGGC AACAGAGGAG CTTGCAGGGC ATGCCTGGGA GGACTAGTGG AGAATTGGGA 
CCATTCAACA ATGGCGCCAG CTACCCTCTT CAAGCTGGGC AGCCGAGACT GACCAAGCAG 
CACTTCCCAC AGGGACTGAG CCAGTCAGTC GTGGATGCTA ACACGGGCAC AGTGAGGACC 
CTCAACCCAG CTGCCATGGG TCGGCAGATG ATGCCATCGC TCCCGGGGCA GCAAGGCACC 
AGCCAGGCGA GGCCAATGGT CATGTCTGGC CTGAGCCAGG GAGTCCCAGG CATGCCAGCG 
TTCAGCCAGC CCCCAGCACA GCAGCAGATA CCCAGTGGCA GCTTTGCTCC AAGCAGCCAG 
AGCCAAGCCT ATGAGCGGAA TGCCCCTCAG GACGTGTCAT ACAATTACAG TGGCGACGGA 
GCTGGGGGTT CCTTCCCTGG CCTCCCGGAC GGTGCAGACC TTGTGGACTC CATCATCAAA 
GGCGGGCCAG GGGACGAGTG GATGCAGGAG CTTGATGAAT TGTTTGGTAA CCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RBPJ and MAML3: Potential Therapeutic Targets for Small Cell Lung Cancer.
Anticancer research38(8)4543-4547(2018 Aug)
Onishi H,Ichimiya S,Yanai K,Umebayashi M,Nakamura K,Yamasaki A,Imaizumi A,Nagai S,Murahashi M,Ogata H,Morisaki T

MiR-2392 suppresses metastasis and epithelial-mesenchymal transition by targeting
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(9)3774-3786(2017 09)
Li J,Li T,Lu Y,Shen G,Guo H,Wu J,Lei C,Du F,Zhou F,Zhao X,Nie Y,Fan D

PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma.
Allergy72(5)792-801(2017 May)
Nieuwenhuis MA,Vonk JM,Himes BE,Sarnowski C,Minelli C,Jarvis D,Bouzigon E,Nickle DC,Laviolette M,Sin D,Weiss ST,van den Berge M,Koppelman GH,Postma DS

Protein-bound Polysaccharide-K Inhibits Hedgehog Signaling Through Down-regulation of MAML3 and RBPJ Transcription Under Hypoxia, Suppressing the Malignant Phenotype in Pancreatic Cancer.
Anticancer research36(8)3945-52(2016 Aug)
Yamasaki A,Onishi H,Imaizumi A,Kawamoto M,Fujimura A,Oyama Y,Katano M

Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma.
Molecular cancer research : MCR14(5)411-22(2016 05)
Heynen GJ,Nevedomskaya E,Palit S,Jagalur Basheer N,Lieftink C,Schlicker A,Zwart W,Bernards R,Bajpe PK

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MAML3 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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