DLL4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DLL4
Entrez Gene ID	54567
Full Name	delta like canonical Notch ligand 4
Synonyms	AOS6,hdelta2
General protein information	Preferred Names delta like canonical Notch ligand 4 Names delta-like protein 4 delta 4 delta ligand 4 delta-like 4 homolog delta-like 4 protein delta4 drosophila Delta homolog 4 notch ligand DLL4 notch ligand delta-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q15.1
Summary	This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008].
Disorder MIM:	605185
Disorder Html:	Adams-Oliver syndrome 6, 616589 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_019074.3	NP_061947.1	delta-like protein 4 precursor
NM_019074.4	NP_061947.1	delta-like protein 4 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	DLL4	XP_002804774.1
Canis lupus familiaris (dog)	DLL4	XP_858084.1
Gallus gallus (chicken)	DLL4	XP_421132.2
Danio rerio (zebrafish)	dll4	NP_001073304.1
Homo sapiens (human)	DLL4	NP_061947.1
Pan troglodytes (chimpanzee)	DLL4	XP_510318.2
Bos taurus (cattle)	DLL4	NP_001069247.1
Mus musculus (house mouse)	Dll4	NP_062327.2
Rattus norvegicus (Norway rat)	Dll4	NP_001101230.1
Xenopus tropicalis (tropical clawed frog)	dll4	XP_002939596.2

Gene Ontology
Bibliography

Related articles in PubMed

DLL4 and Jagged1 are angiogenic targets of orphan nuclear receptor TR3/Nur77.
Peng J, Zhao S, Li Y, Niu G, Chen C, Ye T, Zhao D, Zeng H
Microvascular research12467-75(2019 07)

Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes.
Zheng X, Narayanan S, Sunkari VG, Eliasson S, Botusan IR, Grünler J, Catrina AI, Radtke F, Xu C, Zhao A, Ekberg NR, Lendahl U, Catrina SB
Proceedings of the National Academy of Sciences of the United States of America116(14)6985-6994(2019 04)

Downregulation of DLL4 predicts poor survival in non‑small cell lung cancer patients due to promotion of lymph node metastasis.
Liu H, Peng J, Zhao M, Ma P, Zhong J, Li S, Lu Z
Oncology reports40(5)2988-2996(2018 Nov)

Tumor-endothelial cell interaction in an experimental model of human hepatocellular carcinoma.
Jamshidi-Parsian A, Griffin RJ, Kore RA, Todorova VK, Makhoul I
Experimental cell research372(1)16-24(2018 11)

Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication.
Kunanopparat A, Issara-Amphorn J, Leelahavanichkul A, Sanpavat A, Patumraj S, Tangkijvanich P, Palaga T, Hirankarn N
World journal of gastroenterology24(34)3861-3870(2018 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DLL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DLL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27233	NM_019074.4 Latest version!	Homo sapiens delta like canonical Notch ligand 4 (DLL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu27233	NM_019074.3	Homo sapiens delta like canonical Notch ligand 4 (DLL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DLL4 ( NM_019074.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_061947.1 Homo sapiens delta like canonical Notch ligand 4 (DLL4), mRNA.

Price & Availability↑

CloneID	OHu27233
Clone ID Related Accession (Same CDS sequence)	NM_019074.3 , NM_019074.4
Accession Version	NM_019074.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2058bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512835200000
Organism	Homo sapiens(human)
Product	delta-like protein 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA089757.1, BC106950.2, AB036931.1 and AI478830.1. This sequence is a reference standard in the RefSeqGene project. On Jul 29, 2010 this sequence version replaced NM_019074.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB036931.1, SRR1660805.170337.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCAG CGTCCCGGAG CGCCTCTGGC TGGGCGCTAC TGCTGCTGGT GGCACTTTGG 
CAGCAGCGCG CGGCCGGCTC CGGCGTCTTC CAGCTGCAGC TGCAGGAGTT CATCAACGAG 
CGCGGCGTAC TGGCCAGTGG GCGGCCTTGC GAGCCCGGCT GCCGGACTTT CTTCCGCGTC 
TGCCTTAAGC ACTTCCAGGC GGTCGTCTCG CCCGGACCCT GCACCTTCGG GACCGTCTCC 
ACGCCGGTAT TGGGCACCAA CTCCTTCGCT GTCCGGGACG ACAGTAGCGG CGGGGGGCGC 
AACCCTCTCC AACTGCCCTT CAATTTCACC TGGCCGGGTA CCTTCTCGCT CATCATCGAA 
GCTTGGCACG CGCCAGGAGA CGACCTGCGG CCAGAGGCCT TGCCACCAGA TGCACTCATC 
AGCAAGATCG CCATCCAGGG CTCCCTAGCT GTGGGTCAGA ACTGGTTATT GGATGAGCAA 
ACCAGCACCC TCACAAGGCT GCGCTACTCT TACCGGGTCA TCTGCAGTGA CAACTACTAT 
GGAGACAACT GCTCCCGCCT GTGCAAGAAG CGCAATGACC ACTTCGGCCA CTATGTGTGC 
CAGCCAGATG GCAACTTGTC CTGCCTGCCC GGTTGGACTG GGGAATATTG CCAACAGCCT 
ATCTGTCTTT CGGGCTGTCA TGAACAGAAT GGCTACTGCA GCAAGCCAGC AGAGTGCCTC 
TGCCGCCCAG GCTGGCAGGG CCGGCTGTGT AACGAATGCA TCCCCCACAA TGGCTGTCGC 
CACGGCACCT GCAGCACTCC CTGGCAATGT ACTTGTGATG AGGGCTGGGG AGGCCTGTTT 
TGTGACCAAG ATCTCAACTA CTGCACCCAC CACTCCCCAT GCAAGAATGG GGCAACGTGC 
TCCAACAGTG GGCAGCGAAG CTACACCTGC ACCTGTCGCC CAGGCTACAC TGGTGTGGAC 
TGTGAGCTGG AGCTCAGCGA GTGTGACAGC AACCCCTGTC GCAATGGAGG CAGCTGTAAG 
GACCAGGAGG ATGGCTACCA CTGCCTGTGT CCTCCGGGCT ACTATGGCCT GCATTGTGAA 
CACAGCACCT TGAGCTGCGC CGACTCCCCC TGCTTCAATG GGGGCTCCTG CCGGGAGCGC 
AACCAGGGGG CCAACTATGC TTGTGAATGT CCCCCCAACT TCACCGGCTC CAACTGCGAG 
AAGAAAGTGG ACAGGTGCAC CAGCAACCCC TGTGCCAACG GGGGACAGTG CCTGAACCGA 
GGTCCAAGCC GCATGTGCCG CTGCCGTCCT GGATTCACGG GCACCTACTG TGAACTCCAC 
GTCAGCGACT GTGCCCGTAA CCCTTGCGCC CACGGTGGCA CTTGCCATGA CCTGGAGAAT 
GGGCTCATGT GCACCTGCCC TGCCGGCTTC TCTGGCCGAC GCTGTGAGGT GCGGACATCC 
ATCGATGCCT GTGCCTCGAG TCCCTGCTTC AACAGGGCCA CCTGCTACAC CGACCTCTCC 
ACAGACACCT TTGTGTGCAA CTGCCCTTAT GGCTTTGTGG GCAGCCGCTG CGAGTTCCCC 
GTGGGCTTGC CGCCCAGCTT CCCCTGGGTG GCCGTCTCGC TGGGTGTGGG GCTGGCAGTG 
CTGCTGGTAC TGCTGGGCAT GGTGGCAGTG GCTGTGCGGC AGCTGCGGCT TCGACGGCCG 
GACGACGGCA GCAGGGAAGC CATGAACAAC TTGTCGGACT TCCAGAAGGA CAACCTGATT 
CCTGCCGCCC AGCTTAAAAA CACAAACCAG AAGAAGGAGC TGGAAGTGGA CTGTGGCCTG 
GACAAGTCCA ACTGTGGCAA ACAGCAAAAC CACACATTGG ACTATAATCT GGCCCCAGGG 
CCCCTGGGGC GGGGGACCAT GCCAGGAAAG TTTCCCCACA GTGACAAGAG CTTAGGAGAG 
AAGGCGCCAC TGCGGTTACA CAGTGAAAAG CCAGAGTGTC GGATATCAGC GATATGCTCC 
CCCAGGGACT CCATGTACCA GTCTGTGTGT TTGATATCAG AGGAGAGGAA TGAATGTGTC 
ATTGCCACGG AGGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061947.1
CDS	337..2394
Translation	MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV

Target ORF information:

RefSeq Version	NM_019074.3
Organism	Homo sapiens(human)
Definition	Homo sapiens delta like canonical Notch ligand 4 (DLL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019074.3

ORF Insert Sequence:

ATGGCGGCAG CGTCCCGGAG CGCCTCTGGC TGGGCGCTAC TGCTGCTGGT GGCACTTTGG 
CAGCAGCGCG CGGCCGGCTC CGGCGTCTTC CAGCTGCAGC TGCAGGAGTT CATCAACGAG 
CGCGGCGTAC TGGCCAGTGG GCGGCCTTGC GAGCCCGGCT GCCGGACTTT CTTCCGCGTC 
TGCCTTAAGC ACTTCCAGGC GGTCGTCTCG CCCGGACCCT GCACCTTCGG GACCGTCTCC 
ACGCCGGTAT TGGGCACCAA CTCCTTCGCT GTCCGGGACG ACAGTAGCGG CGGGGGGCGC 
AACCCTCTCC AACTGCCCTT CAATTTCACC TGGCCGGGTA CCTTCTCGCT CATCATCGAA 
GCTTGGCACG CGCCAGGAGA CGACCTGCGG CCAGAGGCCT TGCCACCAGA TGCACTCATC 
AGCAAGATCG CCATCCAGGG CTCCCTAGCT GTGGGTCAGA ACTGGTTATT GGATGAGCAA 
ACCAGCACCC TCACAAGGCT GCGCTACTCT TACCGGGTCA TCTGCAGTGA CAACTACTAT 
GGAGACAACT GCTCCCGCCT GTGCAAGAAG CGCAATGACC ACTTCGGCCA CTATGTGTGC 
CAGCCAGATG GCAACTTGTC CTGCCTGCCC GGTTGGACTG GGGAATATTG CCAACAGCCT 
ATCTGTCTTT CGGGCTGTCA TGAACAGAAT GGCTACTGCA GCAAGCCAGC AGAGTGCCTC 
TGCCGCCCAG GCTGGCAGGG CCGGCTGTGT AACGAATGCA TCCCCCACAA TGGCTGTCGC 
CACGGCACCT GCAGCACTCC CTGGCAATGT ACTTGTGATG AGGGCTGGGG AGGCCTGTTT 
TGTGACCAAG ATCTCAACTA CTGCACCCAC CACTCCCCAT GCAAGAATGG GGCAACGTGC 
TCCAACAGTG GGCAGCGAAG CTACACCTGC ACCTGTCGCC CAGGCTACAC TGGTGTGGAC 
TGTGAGCTGG AGCTCAGCGA GTGTGACAGC AACCCCTGTC GCAATGGAGG CAGCTGTAAG 
GACCAGGAGG ATGGCTACCA CTGCCTGTGT CCTCCGGGCT ACTATGGCCT GCATTGTGAA 
CACAGCACCT TGAGCTGCGC CGACTCCCCC TGCTTCAATG GGGGCTCCTG CCGGGAGCGC 
AACCAGGGGG CCAACTATGC TTGTGAATGT CCCCCCAACT TCACCGGCTC CAACTGCGAG 
AAGAAAGTGG ACAGGTGCAC CAGCAACCCC TGTGCCAACG GGGGACAGTG CCTGAACCGA 
GGTCCAAGCC GCATGTGCCG CTGCCGTCCT GGATTCACGG GCACCTACTG TGAACTCCAC 
GTCAGCGACT GTGCCCGTAA CCCTTGCGCC CACGGTGGCA CTTGCCATGA CCTGGAGAAT 
GGGCTCATGT GCACCTGCCC TGCCGGCTTC TCTGGCCGAC GCTGTGAGGT GCGGACATCC 
ATCGATGCCT GTGCCTCGAG TCCCTGCTTC AACAGGGCCA CCTGCTACAC CGACCTCTCC 
ACAGACACCT TTGTGTGCAA CTGCCCTTAT GGCTTTGTGG GCAGCCGCTG CGAGTTCCCC 
GTGGGCTTGC CGCCCAGCTT CCCCTGGGTG GCCGTCTCGC TGGGTGTGGG GCTGGCAGTG 
CTGCTGGTAC TGCTGGGCAT GGTGGCAGTG GCTGTGCGGC AGCTGCGGCT TCGACGGCCG 
GACGACGGCA GCAGGGAAGC CATGAACAAC TTGTCGGACT TCCAGAAGGA CAACCTGATT 
CCTGCCGCCC AGCTTAAAAA CACAAACCAG AAGAAGGAGC TGGAAGTGGA CTGTGGCCTG 
GACAAGTCCA ACTGTGGCAA ACAGCAAAAC CACACATTGG ACTATAATCT GGCCCCAGGG 
CCCCTGGGGC GGGGGACCAT GCCAGGAAAG TTTCCCCACA GTGACAAGAG CTTAGGAGAG 
AAGGCGCCAC TGCGGTTACA CAGTGAAAAG CCAGAGTGTC GGATATCAGC GATATGCTCC 
CCCAGGGACT CCATGTACCA GTCTGTGTGT TTGATATCAG AGGAGAGGAA TGAATGTGTC 
ATTGCCACGG AGGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLL4 ( NM_019074.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_061947.1 Homo sapiens delta like canonical Notch ligand 4 (DLL4), mRNA.

Price & Availability↑

CloneID	OHu27233
Clone ID Related Accession (Same CDS sequence)	NM_019074.3 , NM_019074.4
Accession Version	NM_019074.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2058bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	delta-like protein 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA089757.1, BC106950.2, AB036931.1, AI478830.1 and HY291308.1. This sequence is a reference standard in the RefSeqGene project. On Aug 6, 2018 this sequence version replaced NM_019074.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.104185.1, SRR1660805.112319.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000249749.7/ ENSP00000249749.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCGGCAG CGTCCCGGAG CGCCTCTGGC TGGGCGCTAC TGCTGCTGGT GGCACTTTGG 
CAGCAGCGCG CGGCCGGCTC CGGCGTCTTC CAGCTGCAGC TGCAGGAGTT CATCAACGAG 
CGCGGCGTAC TGGCCAGTGG GCGGCCTTGC GAGCCCGGCT GCCGGACTTT CTTCCGCGTC 
TGCCTTAAGC ACTTCCAGGC GGTCGTCTCG CCCGGACCCT GCACCTTCGG GACCGTCTCC 
ACGCCGGTAT TGGGCACCAA CTCCTTCGCT GTCCGGGACG ACAGTAGCGG CGGGGGGCGC 
AACCCTCTCC AACTGCCCTT CAATTTCACC TGGCCGGGTA CCTTCTCGCT CATCATCGAA 
GCTTGGCACG CGCCAGGAGA CGACCTGCGG CCAGAGGCCT TGCCACCAGA TGCACTCATC 
AGCAAGATCG CCATCCAGGG CTCCCTAGCT GTGGGTCAGA ACTGGTTATT GGATGAGCAA 
ACCAGCACCC TCACAAGGCT GCGCTACTCT TACCGGGTCA TCTGCAGTGA CAACTACTAT 
GGAGACAACT GCTCCCGCCT GTGCAAGAAG CGCAATGACC ACTTCGGCCA CTATGTGTGC 
CAGCCAGATG GCAACTTGTC CTGCCTGCCC GGTTGGACTG GGGAATATTG CCAACAGCCT 
ATCTGTCTTT CGGGCTGTCA TGAACAGAAT GGCTACTGCA GCAAGCCAGC AGAGTGCCTC 
TGCCGCCCAG GCTGGCAGGG CCGGCTGTGT AACGAATGCA TCCCCCACAA TGGCTGTCGC 
CACGGCACCT GCAGCACTCC CTGGCAATGT ACTTGTGATG AGGGCTGGGG AGGCCTGTTT 
TGTGACCAAG ATCTCAACTA CTGCACCCAC CACTCCCCAT GCAAGAATGG GGCAACGTGC 
TCCAACAGTG GGCAGCGAAG CTACACCTGC ACCTGTCGCC CAGGCTACAC TGGTGTGGAC 
TGTGAGCTGG AGCTCAGCGA GTGTGACAGC AACCCCTGTC GCAATGGAGG CAGCTGTAAG 
GACCAGGAGG ATGGCTACCA CTGCCTGTGT CCTCCGGGCT ACTATGGCCT GCATTGTGAA 
CACAGCACCT TGAGCTGCGC CGACTCCCCC TGCTTCAATG GGGGCTCCTG CCGGGAGCGC 
AACCAGGGGG CCAACTATGC TTGTGAATGT CCCCCCAACT TCACCGGCTC CAACTGCGAG 
AAGAAAGTGG ACAGGTGCAC CAGCAACCCC TGTGCCAACG GGGGACAGTG CCTGAACCGA 
GGTCCAAGCC GCATGTGCCG CTGCCGTCCT GGATTCACGG GCACCTACTG TGAACTCCAC 
GTCAGCGACT GTGCCCGTAA CCCTTGCGCC CACGGTGGCA CTTGCCATGA CCTGGAGAAT 
GGGCTCATGT GCACCTGCCC TGCCGGCTTC TCTGGCCGAC GCTGTGAGGT GCGGACATCC 
ATCGATGCCT GTGCCTCGAG TCCCTGCTTC AACAGGGCCA CCTGCTACAC CGACCTCTCC 
ACAGACACCT TTGTGTGCAA CTGCCCTTAT GGCTTTGTGG GCAGCCGCTG CGAGTTCCCC 
GTGGGCTTGC CGCCCAGCTT CCCCTGGGTG GCCGTCTCGC TGGGTGTGGG GCTGGCAGTG 
CTGCTGGTAC TGCTGGGCAT GGTGGCAGTG GCTGTGCGGC AGCTGCGGCT TCGACGGCCG 
GACGACGGCA GCAGGGAAGC CATGAACAAC TTGTCGGACT TCCAGAAGGA CAACCTGATT 
CCTGCCGCCC AGCTTAAAAA CACAAACCAG AAGAAGGAGC TGGAAGTGGA CTGTGGCCTG 
GACAAGTCCA ACTGTGGCAA ACAGCAAAAC CACACATTGG ACTATAATCT GGCCCCAGGG 
CCCCTGGGGC GGGGGACCAT GCCAGGAAAG TTTCCCCACA GTGACAAGAG CTTAGGAGAG 
AAGGCGCCAC TGCGGTTACA CAGTGAAAAG CCAGAGTGTC GGATATCAGC GATATGCTCC 
CCCAGGGACT CCATGTACCA GTCTGTGTGT TTGATATCAG AGGAGAGGAA TGAATGTGTC 
ATTGCCACGG AGGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061947.1
CDS	330..2387
Translation	MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV

Target ORF information:

RefSeq Version	NM_019074.4
Organism	Homo sapiens(human)
Definition	Homo sapiens delta like canonical Notch ligand 4 (DLL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019074.4

ORF Insert Sequence:

ATGGCGGCAG CGTCCCGGAG CGCCTCTGGC TGGGCGCTAC TGCTGCTGGT GGCACTTTGG 
CAGCAGCGCG CGGCCGGCTC CGGCGTCTTC CAGCTGCAGC TGCAGGAGTT CATCAACGAG 
CGCGGCGTAC TGGCCAGTGG GCGGCCTTGC GAGCCCGGCT GCCGGACTTT CTTCCGCGTC 
TGCCTTAAGC ACTTCCAGGC GGTCGTCTCG CCCGGACCCT GCACCTTCGG GACCGTCTCC 
ACGCCGGTAT TGGGCACCAA CTCCTTCGCT GTCCGGGACG ACAGTAGCGG CGGGGGGCGC 
AACCCTCTCC AACTGCCCTT CAATTTCACC TGGCCGGGTA CCTTCTCGCT CATCATCGAA 
GCTTGGCACG CGCCAGGAGA CGACCTGCGG CCAGAGGCCT TGCCACCAGA TGCACTCATC 
AGCAAGATCG CCATCCAGGG CTCCCTAGCT GTGGGTCAGA ACTGGTTATT GGATGAGCAA 
ACCAGCACCC TCACAAGGCT GCGCTACTCT TACCGGGTCA TCTGCAGTGA CAACTACTAT 
GGAGACAACT GCTCCCGCCT GTGCAAGAAG CGCAATGACC ACTTCGGCCA CTATGTGTGC 
CAGCCAGATG GCAACTTGTC CTGCCTGCCC GGTTGGACTG GGGAATATTG CCAACAGCCT 
ATCTGTCTTT CGGGCTGTCA TGAACAGAAT GGCTACTGCA GCAAGCCAGC AGAGTGCCTC 
TGCCGCCCAG GCTGGCAGGG CCGGCTGTGT AACGAATGCA TCCCCCACAA TGGCTGTCGC 
CACGGCACCT GCAGCACTCC CTGGCAATGT ACTTGTGATG AGGGCTGGGG AGGCCTGTTT 
TGTGACCAAG ATCTCAACTA CTGCACCCAC CACTCCCCAT GCAAGAATGG GGCAACGTGC 
TCCAACAGTG GGCAGCGAAG CTACACCTGC ACCTGTCGCC CAGGCTACAC TGGTGTGGAC 
TGTGAGCTGG AGCTCAGCGA GTGTGACAGC AACCCCTGTC GCAATGGAGG CAGCTGTAAG 
GACCAGGAGG ATGGCTACCA CTGCCTGTGT CCTCCGGGCT ACTATGGCCT GCATTGTGAA 
CACAGCACCT TGAGCTGCGC CGACTCCCCC TGCTTCAATG GGGGCTCCTG CCGGGAGCGC 
AACCAGGGGG CCAACTATGC TTGTGAATGT CCCCCCAACT TCACCGGCTC CAACTGCGAG 
AAGAAAGTGG ACAGGTGCAC CAGCAACCCC TGTGCCAACG GGGGACAGTG CCTGAACCGA 
GGTCCAAGCC GCATGTGCCG CTGCCGTCCT GGATTCACGG GCACCTACTG TGAACTCCAC 
GTCAGCGACT GTGCCCGTAA CCCTTGCGCC CACGGTGGCA CTTGCCATGA CCTGGAGAAT 
GGGCTCATGT GCACCTGCCC TGCCGGCTTC TCTGGCCGAC GCTGTGAGGT GCGGACATCC 
ATCGATGCCT GTGCCTCGAG TCCCTGCTTC AACAGGGCCA CCTGCTACAC CGACCTCTCC 
ACAGACACCT TTGTGTGCAA CTGCCCTTAT GGCTTTGTGG GCAGCCGCTG CGAGTTCCCC 
GTGGGCTTGC CGCCCAGCTT CCCCTGGGTG GCCGTCTCGC TGGGTGTGGG GCTGGCAGTG 
CTGCTGGTAC TGCTGGGCAT GGTGGCAGTG GCTGTGCGGC AGCTGCGGCT TCGACGGCCG 
GACGACGGCA GCAGGGAAGC CATGAACAAC TTGTCGGACT TCCAGAAGGA CAACCTGATT 
CCTGCCGCCC AGCTTAAAAA CACAAACCAG AAGAAGGAGC TGGAAGTGGA CTGTGGCCTG 
GACAAGTCCA ACTGTGGCAA ACAGCAAAAC CACACATTGG ACTATAATCT GGCCCCAGGG 
CCCCTGGGGC GGGGGACCAT GCCAGGAAAG TTTCCCCACA GTGACAAGAG CTTAGGAGAG 
AAGGCGCCAC TGCGGTTACA CAGTGAAAAG CCAGAGTGTC GGATATCAGC GATATGCTCC 
CCCAGGGACT CCATGTACCA GTCTGTGTGT TTGATATCAG AGGAGAGGAA TGAATGTGTC 
ATTGCCACGG AGGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DLL4 and Jagged1 are angiogenic targets of orphan nuclear receptor TR3/Nur77.
Microvascular research12467-75(2019 07)
Peng J,Zhao S,Li Y,Niu G,Chen C,Ye T,Zhao D,Zeng H

Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes.
Proceedings of the National Academy of Sciences of the United States of America116(14)6985-6994(2019 04)
Zheng X,Narayanan S,Sunkari VG,Eliasson S,Botusan IR,Grünler J,Catrina AI,Radtke F,Xu C,Zhao A,Ekberg NR,Lendahl U,Catrina SB

Downregulation of DLL4 predicts poor survival in non‑small cell lung cancer patients due to promotion of lymph node metastasis.
Oncology reports40(5)2988-2996(2018 Nov)
Liu H,Peng J,Zhao M,Ma P,Zhong J,Li S,Lu Z

Tumor-endothelial cell interaction in an experimental model of human hepatocellular carcinoma.
Experimental cell research372(1)16-24(2018 11)
Jamshidi-Parsian A,Griffin RJ,Kore RA,Todorova VK,Makhoul I

Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication.
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DLL4 cDNA ORF clone, Homo sapiens(human)

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