| Gene Symbol | PPIL1 |
| Entrez Gene ID | 51645 |
| Full Name | peptidylprolyl isomerase like 1 |
| Synonyms | CGI-124,CYPL1,PPIase,hCyPX |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
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PPIL1 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following PPIL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPIL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu10401 Clone ID Related Accession (Same CDS sequence) NM_016059.4 , NM_016059.5 Accession Version NM_016059.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 501bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1511712000000 Organism Homo sapiens(human) Product peptidyl-prolyl cis-trans isomerase-like 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU195579.1, AL122034.29 and AK026636.1. On Dec 5, 2008 this sequence version replaced NM_016059.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.562934.1, AY359032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481ATGGCGGCAA TTCCCCCAGA TTCCTGGCAG CCACCCAACG TTTACTTGGA GACCAGCATG
GGAATCATTG TGCTGGAGCT GTACTGGAAG CATGCTCCAA AGACCTGTAA GAACTTTGCT
GAGTTGGCTC GTCGAGGTTA CTACAATGGC ACAAAATTCC ACAGAATTAT CAAAGACTTC
ATGATCCAAG GAGGTGACCC AACAGGGACA GGTCGAGGTG GTGCATCTAT CTATGGCAAA
CAGTTTGAAG ATGAACTTCA TCCAGACTTG AAATTCACGG GGGCTGGAAT TCTCGCAATG
GCCAATGCGG GGCCAGATAC CAATGGCAGC CAGTTCTTTG TGACCCTCGC CCCCACCCAG
TGGCTTGACG GCAAACACAC CATTTTTGGC CGAGTGTGTC AGGGCATAGG AATGGTGAAT
CGCGTGGGAA TGGTAGAAAC AAACTCCCAG GACCGCCCTG TGGACGACGT GAAGATCATT
AAGGCATACC CTTCTGGGTA GThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_057143.1 CDS 253..753 Translation 
Target ORF information:
RefSeq Version NM_016059.4 Organism Homo sapiens(human) Definition Homo sapiens peptidylprolyl isomerase like 1 (PPIL1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_016059.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481ATGGCGGCAA TTCCCCCAGA TTCCTGGCAG CCACCCAACG TTTACTTGGA GACCAGCATG
GGAATCATTG TGCTGGAGCT GTACTGGAAG CATGCTCCAA AGACCTGTAA GAACTTTGCT
GAGTTGGCTC GTCGAGGTTA CTACAATGGC ACAAAATTCC ACAGAATTAT CAAAGACTTC
ATGATCCAAG GAGGTGACCC AACAGGGACA GGTCGAGGTG GTGCATCTAT CTATGGCAAA
CAGTTTGAAG ATGAACTTCA TCCAGACTTG AAATTCACGG GGGCTGGAAT TCTCGCAATG
GCCAATGCGG GGCCAGATAC CAATGGCAGC CAGTTCTTTG TGACCCTCGC CCCCACCCAG
TGGCTTGACG GCAAACACAC CATTTTTGGC CGAGTGTGTC AGGGCATAGG AATGGTGAAT
CGCGTGGGAA TGGTAGAAAC AAACTCCCAG GACCGCCCTG TGGACGACGT GAAGATCATT
AAGGCATACC CTTCTGGGTA GThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu10401 Clone ID Related Accession (Same CDS sequence) NM_016059.4 , NM_016059.5 Accession Version NM_016059.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 501bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570636800000 Organism Homo sapiens(human) Product peptidyl-prolyl cis-trans isomerase-like 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK026636.1. On Nov 23, 2018 this sequence version replaced NM_016059.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003048.1, AK026636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373699.6/ ENSP00000362803.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481ATGGCGGCAA TTCCCCCAGA TTCCTGGCAG CCACCCAACG TTTACTTGGA GACCAGCATG
GGAATCATTG TGCTGGAGCT GTACTGGAAG CATGCTCCAA AGACCTGTAA GAACTTTGCT
GAGTTGGCTC GTCGAGGTTA CTACAATGGC ACAAAATTCC ACAGAATTAT CAAAGACTTC
ATGATCCAAG GAGGTGACCC AACAGGGACA GGTCGAGGTG GTGCATCTAT CTATGGCAAA
CAGTTTGAAG ATGAACTTCA TCCAGACTTG AAATTCACGG GGGCTGGAAT TCTCGCAATG
GCCAATGCGG GGCCAGATAC CAATGGCAGC CAGTTCTTTG TGACCCTCGC CCCCACCCAG
TGGCTTGACG GCAAACACAC CATTTTTGGC CGAGTGTGTC AGGGCATAGG AATGGTGAAT
CGCGTGGGAA TGGTAGAAAC AAACTCCCAG GACCGCCCTG TGGACGACGT GAAGATCATT
AAGGCATACC CTTCTGGGTA GThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_057143.1 CDS 32..532 Translation
Target ORF information:
RefSeq Version NM_016059.5 Organism Homo sapiens(human) Definition Homo sapiens peptidylprolyl isomerase like 1 (PPIL1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_016059.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481ATGGCGGCAA TTCCCCCAGA TTCCTGGCAG CCACCCAACG TTTACTTGGA GACCAGCATG
GGAATCATTG TGCTGGAGCT GTACTGGAAG CATGCTCCAA AGACCTGTAA GAACTTTGCT
GAGTTGGCTC GTCGAGGTTA CTACAATGGC ACAAAATTCC ACAGAATTAT CAAAGACTTC
ATGATCCAAG GAGGTGACCC AACAGGGACA GGTCGAGGTG GTGCATCTAT CTATGGCAAA
CAGTTTGAAG ATGAACTTCA TCCAGACTTG AAATTCACGG GGGCTGGAAT TCTCGCAATG
GCCAATGCGG GGCCAGATAC CAATGGCAGC CAGTTCTTTG TGACCCTCGC CCCCACCCAG
TGGCTTGACG GCAAACACAC CATTTTTGGC CGAGTGTGTC AGGGCATAGG AATGGTGAAT
CGCGTGGGAA TGGTAGAAAC AAACTCCCAG GACCGCCCTG TGGACGACGT GAAGATCATT
AAGGCATACC CTTCTGGGTA GThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW
Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature542(7641)318-323(2017 02)
Bertram K,Agafonov DE,Liu WT,Dybkov O,Will CL,Hartmuth K,Urlaub H,Kastner B,Stark H,Lührmann R
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,Déret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN
Dynamic protein-protein interaction wiring of the human spliceosome.
Molecular cell45(4)567-80(2012 Feb)
Hegele A,Kamburov A,Grossmann A,Sourlis C,Wowro S,Weimann M,Will CL,Pena V,Lührmann R,Stelzl U
Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS biology8(7)e1000439(2010 Jul)
Davis TL,Walker JR,Campagna-Slater V,Finerty PJ,Paramanathan R,Bernstein G,MacKenzie F,Tempel W,Ouyang H,Lee WH,Eisenmesser EZ,Dhe-Paganon S
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