TMEM216 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM216
Entrez Gene ID	51259
Full Name	transmembrane protein 216
Synonyms	HSPC244
General protein information	Preferred Names transmembrane protein 216 Names transmembrane protein 216
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.2
Summary	This locus encodes a transmembrane domain-containing protein. Mutations at this locus have been associated with Meckel-Gruber Syndrome Type 2, and Joubert Syndrome 2, also known as Cerebello-oculorenal Syndrome 2. [provided by RefSeq, Aug 2010].
Disorder MIM:	613277
Disorder Html:	Joubert syndrome 2, 608091 (3); Meckel syndrome 2, 603194 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001173991.2	NP_001167462.1	transmembrane protein 216 isoform 3
NM_001330285.1	NP_001317214.1	transmembrane protein 216 isoform 4
NM_016499.5	NP_057583.2	transmembrane protein 216 isoform 1
XM_005274039.4	XP_005274096.1	transmembrane protein 216 isoform X1
NM_001173990.2	NP_001167461.1	transmembrane protein 216 isoform 2
NM_001173990.3	NP_001167461.1	transmembrane protein 216 isoform 2
XM_005274039.3	XP_005274096.1	transmembrane protein 216 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TMEM216	NP_001167462.1
Gallus gallus (chicken)	TMEM216	XP_001236892.2
Danio rerio (zebrafish)	LOC555988	XP_683769.2
Macaca mulatta (Rhesus monkey)	TMEM216	XP_001082614.2
Xenopus tropicalis (tropical clawed frog)	LOC100490116	XP_002943747.2
Pan troglodytes (chimpanzee)	TMEM216	NP_001229497.1
Mus musculus (house mouse)	Tmem216	NP_001264789.1
Rattus norvegicus (Norway rat)	Tmem216	NP_001257968.1
Canis lupus familiaris (dog)	TMEM216	XP_005631719.1

Gene Ontology
Bibliography

Related articles in PubMed

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.
Lambacher NJ, Bruel AL, van Dam TJ, Szymańska K, Slaats GG, Kuhns S, McManus GJ, Kennedy JE, Gaff K, Wu KM, van der Lee R, Burglen L, Doummar D, Rivière JB, Faivre L, Attié-Bitach T, Saunier S, Curd A, Peckham M, Giles RH, Johnson CA, Huynen MA, Thauvin-Robinet C, Blacque OE
Nature cell biology18(1)122-31(2016 Jan)

Evolutionarily assembled cis-regulatory module at a human ciliopathy locus.
Lee JH, Silhavy JL, Lee JE, Al-Gazali L, Thomas S, Davis EE, Bielas SL, Hill KJ, Iannicelli M, Brancati F, Gabriel SB, Russ C, Logan CV, Sharif SM, Bennett CP, Abe M, Hildebrandt F, Diplas BH, Attié-Bitach T, Katsanis N, Rajab A, Koul R, Sztriha L, Waters ER, Ferro-Novick S, Woods CG, Johnson CA, Valente EM, Zaki MS, Gleeson JG
Science (New York, N.Y.)335(6071)966-9(2012 Feb)

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.
Otto EA, Ramaswami G, Janssen S, Chaki M, Allen SJ, Zhou W, Airik R, Hurd TW, Ghosh AK, Wolf MT, Hoppe B, Neuhaus TJ, Bockenhauer D, Milford DV, Soliman NA, Antignac C, Saunier S, Johnson CA, Hildebrandt F,
Journal of medical genetics48(2)105-16(2011 Feb)

Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes.
Valente EM, Logan CV, Mougou-Zerelli S, Lee JH, Silhavy JL, Brancati F, Iannicelli M, Travaglini L, Romani S, Illi B, Adams M, Szymanska K, Mazzotta A, Lee JE, Tolentino JC, Swistun D, Salpietro CD, Fede C, Gabriel S, Russ C, Cibulskis K, Sougnez C, Hildebrandt F, Otto EA, Held S, Diplas BH, Davis EE, Mikula M, Strom CM, Ben-Zeev B, Lev D, Sagie TL, Michelson M, Yaron Y, Krause A, Boltshauser E, Elkhartoufi N, Roume J, Shalev S, Munnich A, Saunier S, Inglehearn C, Saad A, Alkindy A, Thomas S, Vekemans M, Dallapiccola B, Katsanis N, Johnson CA, Attié-Bitach T, Gleeson JG
Nature genetics42(7)619-25(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TMEM216 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM216 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu100638	NM_001330285.1 Latest version!	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu20600	NM_001173991.2 Latest version!	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu20599	NM_016499.5 Latest version!	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu20850	NM_001173990.3 Latest version!	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu20599	XM_005274039.4 Latest version!	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu20850	NM_001173990.2	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu20599	XM_005274039.3	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM216 ( NM_001330285.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317214.1 Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu100638
Clone ID Related Accession (Same CDS sequence)	NM_001330285.1
Accession Version	NM_001330285.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 255bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564588800000
Organism	Homo sapiens(human)
Product	transmembrane protein 216 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303687.1, KU159424.1 and AP003108.3. On Aug 20, 2016 this sequence version replaced XM_017017882.1. ##Evidence-Data-START## Transcript exon combination :: KU159424.1, SRR1163658.517357.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG 
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT 
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT 
TTCTCCAGGA TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317214.1
CDS	470..724
Translation	MLLLYLGIEVIRLFFGTKGNLCQRKMPLSISVALTFPSAMMASYYLLLQTYVLRLEAIMNGILLFFCGSELLLEVLTLAAFSRI

Target ORF information:

RefSeq Version	NM_001330285.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001330285.1

ORF Insert Sequence:

ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG 
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT 
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT 
TTCTCCAGGA TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM216 ( NM_001173991.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001167462.1 Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu20600
Clone ID Related Accession (Same CDS sequence)	NM_001173991.2
Accession Version	NM_001173991.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564675200000
Organism	Homo sapiens(human)
Product	transmembrane protein 216 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303687.1, DN998400.1, AP003108.3 and AA022661.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2010 this sequence version replaced NM_001173991.1. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.371470.1, SRR1803617.393017.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCAC GGGGACTGAA GATGGCGCCG CGAGGTAAAC GGTTGTCCTC CACCCCGCTG 
GAAATCCTGT TCTTTCTGAA CGGGTGGTAT AATGCTACCT ATTTCCTGCT GGAACTTTTC 
ATATTTCTGT ATAAAGGTGT CCTGCTACCA TATCCAACAG CTAACCTAGT ACTGGATGTG 
GTGATGCTCC TCCTTTATCT TGGAATTGAA GTAATTCGCC TGTTTTTTGG TACAAAGGGA 
AACCTCTGCC AGCGAAAGAT GCCGCTCAGT ATTAGCGTGG CCTTGACCTT CCCATCTGCC 
ATGATGGCCT CCTATTACCT GCTGCTGCAG ACCTACGTAC TCCGCCTGGA AGCCATCATG 
AATGGCATCT TGCTCTTCTT CTGTGGCTCA GAGCTTTTAC TTGAGGTGCT CACCTTGGCT 
GCTTTCTCCA GTATGGACAG GATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001167462.1
CDS	273..719
Translation	MLPRGLKMAPRGKRLSSTPLEILFFLNGWYNATYFLLELFIFLYKGVLLPYPTANLVLDVVMLLLYLGIEVIRLFFGTKGNLCQRKMPLSISVALTFPSAMMASYYLLLQTYVLRLEAIMNGILLFFCGSELLLEVLTLAAFSSMDRI

Target ORF information:

RefSeq Version	NM_001173991.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173991.2

ORF Insert Sequence:

ATGCTGCCAC GGGGACTGAA GATGGCGCCG CGAGGTAAAC GGTTGTCCTC CACCCCGCTG 
GAAATCCTGT TCTTTCTGAA CGGGTGGTAT AATGCTACCT ATTTCCTGCT GGAACTTTTC 
ATATTTCTGT ATAAAGGTGT CCTGCTACCA TATCCAACAG CTAACCTAGT ACTGGATGTG 
GTGATGCTCC TCCTTTATCT TGGAATTGAA GTAATTCGCC TGTTTTTTGG TACAAAGGGA 
AACCTCTGCC AGCGAAAGAT GCCGCTCAGT ATTAGCGTGG CCTTGACCTT CCCATCTGCC 
ATGATGGCCT CCTATTACCT GCTGCTGCAG ACCTACGTAC TCCGCCTGGA AGCCATCATG 
AATGGCATCT TGCTCTTCTT CTGTGGCTCA GAGCTTTTAC TTGAGGTGCT CACCTTGGCT 
GCTTTCTCCA GTATGGACAG GATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM216 ( NM_016499.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057583.2 Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20599
Clone ID Related Accession (Same CDS sequence)	NM_016499.5 , XM_005274039.4 , XM_005274039.3
Accession Version	NM_016499.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564588800000
Organism	Homo sapiens(human)
Product	transmembrane protein 216 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG759319.1, BC011010.1, AP003108.3 and AA022661.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2010 this sequence version replaced NM_016499.4. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.432686.1, BC011010.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG 
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT 
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT 
TTCTCCAGTA TGGACAGGAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057583.2
CDS	437..700
Translation	MLLLYLGIEVIRLFFGTKGNLCQRKMPLSISVALTFPSAMMASYYLLLQTYVLRLEAIMNGILLFFCGSELLLEVLTLAAFSSMDRI

Target ORF information:

RefSeq Version	NM_016499.5
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016499.5

ORF Insert Sequence:

ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG 
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT 
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT 
TTCTCCAGTA TGGACAGGAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM216 ( NM_001173990.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001167461.1 Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20850
Clone ID Related Accession (Same CDS sequence)	NM_001173990.2 , NM_001173990.3
Accession Version	NM_001173990.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550764800000
Organism	Homo sapiens(human)
Product	transmembrane protein 216 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303687.1, AP003108.3 and AA022661.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2010 this sequence version replaced NM_001173990.1. ##Evidence-Data-START## Transcript exon combination :: AK303687.1, SRR1163655.641051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCAC GGGGACTGAA GATGGCGCCG CGAGGTAAAC GGTTGTCCTC CACCCCGCTG 
GAAATCCTGT TCTTTCTGAA CGGGTGGTAT AATGCTACCT ATTTCCTGCT GGAACTTTTC 
ATATTTCTGT ATAAAGGTGT CCTGCTACCA TATCCAACAG CTAACCTAGT ACTGGATGTG 
GTGATGCTCC TCCTTTATCT TGGAATTGAA GTAATTCGCC TGTTTTTTGG TACAAAGGGA 
AACCTCTGCC AGCGAAAGAT GCCGCTCAGT ATTAGCGTGG CCTTGACCTT CCCATCTGCC 
ATGATGGCCT CCTATTACCT GCTGCTGCAG ACCTACGTAC TCCGCCTGGA AGCCATCATG 
AATGGCATCT TGCTCTTCTT CTGTGGCTCA GAGCTTTTAC TTGAGGTGCT CACCTTGGCT 
GCTTTCTCCA GGATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001167461.1
CDS	273..710
Translation	MLPRGLKMAPRGKRLSSTPLEILFFLNGWYNATYFLLELFIFLYKGVLLPYPTANLVLDVVMLLLYLGIEVIRLFFGTKGNLCQRKMPLSISVALTFPSAMMASYYLLLQTYVLRLEAIMNGILLFFCGSELLLEVLTLAAFSRI

Target ORF information:

RefSeq Version	NM_001173990.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173990.2

ORF Insert Sequence:

ATGCTGCCAC GGGGACTGAA GATGGCGCCG CGAGGTAAAC GGTTGTCCTC CACCCCGCTG 
GAAATCCTGT TCTTTCTGAA CGGGTGGTAT AATGCTACCT ATTTCCTGCT GGAACTTTTC 
ATATTTCTGT ATAAAGGTGT CCTGCTACCA TATCCAACAG CTAACCTAGT ACTGGATGTG 
GTGATGCTCC TCCTTTATCT TGGAATTGAA GTAATTCGCC TGTTTTTTGG TACAAAGGGA 
AACCTCTGCC AGCGAAAGAT GCCGCTCAGT ATTAGCGTGG CCTTGACCTT CCCATCTGCC 
ATGATGGCCT CCTATTACCT GCTGCTGCAG ACCTACGTAC TCCGCCTGGA AGCCATCATG 
AATGGCATCT TGCTCTTCTT CTGTGGCTCA GAGCTTTTAC TTGAGGTGCT CACCTTGGCT 
GCTTTCTCCA GGATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM216 ( NM_001173990.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001167461.1 Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20850
Clone ID Related Accession (Same CDS sequence)	NM_001173990.2 , NM_001173990.3
Accession Version	NM_001173990.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571932800000
Organism	Homo sapiens(human)
Product	transmembrane protein 216 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303687.1, AP003108.3 and AA022661.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001173990.2. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.389487.1, SRR1163658.302095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000515837.7/ ENSP00000440638.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCAC GGGGACTGAA GATGGCGCCG CGAGGTAAAC GGTTGTCCTC CACCCCGCTG 
GAAATCCTGT TCTTTCTGAA CGGGTGGTAT AATGCTACCT ATTTCCTGCT GGAACTTTTC 
ATATTTCTGT ATAAAGGTGT CCTGCTACCA TATCCAACAG CTAACCTAGT ACTGGATGTG 
GTGATGCTCC TCCTTTATCT TGGAATTGAA GTAATTCGCC TGTTTTTTGG TACAAAGGGA 
AACCTCTGCC AGCGAAAGAT GCCGCTCAGT ATTAGCGTGG CCTTGACCTT CCCATCTGCC 
ATGATGGCCT CCTATTACCT GCTGCTGCAG ACCTACGTAC TCCGCCTGGA AGCCATCATG 
AATGGCATCT TGCTCTTCTT CTGTGGCTCA GAGCTTTTAC TTGAGGTGCT CACCTTGGCT 
GCTTTCTCCA GGATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001167461.1
CDS	46..483
Translation	MLPRGLKMAPRGKRLSSTPLEILFFLNGWYNATYFLLELFIFLYKGVLLPYPTANLVLDVVMLLLYLGIEVIRLFFGTKGNLCQRKMPLSISVALTFPSAMMASYYLLLQTYVLRLEAIMNGILLFFCGSELLLEVLTLAAFSRI

Target ORF information:

RefSeq Version	NM_001173990.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173990.3

ORF Insert Sequence:

ATGCTGCCAC GGGGACTGAA GATGGCGCCG CGAGGTAAAC GGTTGTCCTC CACCCCGCTG 
GAAATCCTGT TCTTTCTGAA CGGGTGGTAT AATGCTACCT ATTTCCTGCT GGAACTTTTC 
ATATTTCTGT ATAAAGGTGT CCTGCTACCA TATCCAACAG CTAACCTAGT ACTGGATGTG 
GTGATGCTCC TCCTTTATCT TGGAATTGAA GTAATTCGCC TGTTTTTTGG TACAAAGGGA 
AACCTCTGCC AGCGAAAGAT GCCGCTCAGT ATTAGCGTGG CCTTGACCTT CCCATCTGCC 
ATGATGGCCT CCTATTACCT GCTGCTGCAG ACCTACGTAC TCCGCCTGGA AGCCATCATG 
AATGGCATCT TGCTCTTCTT CTGTGGCTCA GAGCTTTTAC TTGAGGTGCT CACCTTGGCT 
GCTTTCTCCA GGATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM216 ( XM_005274039.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005274096.1 Homo sapiens transmembrane protein 216 (TMEM216), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu20599
Clone ID Related Accession (Same CDS sequence)	NM_016499.5 , XM_005274039.4 , XM_005274039.3
Accession Version	XM_005274039.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	transmembrane protein 216 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005274039.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG 
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT 
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT 
TTCTCCAGTA TGGACAGGAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005274096.1
CDS	982..1245
Translation	MLLLYLGIEVIRLFFGTKGNLCQRKMPLSISVALTFPSAMMASYYLLLQTYVLRLEAIMNGILLFFCGSELLLEVLTLAAFSSMDRI

Target ORF information:

RefSeq Version	XM_005274039.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005274039.4

ORF Insert Sequence:

ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG 
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT 
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT 
TTCTCCAGTA TGGACAGGAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM216 ( XM_005274039.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005274096.1 Homo sapiens transmembrane protein 216 (TMEM216), transcript variant X1, mRNA.

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CloneID	OHu20599
Clone ID Related Accession (Same CDS sequence)	NM_016499.5 , XM_005274039.4 , XM_005274039.3
Accession Version	XM_005274039.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	transmembrane protein 216 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005274039.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG 
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT 
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT 
TTCTCCAGTA TGGACAGGAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005274096.1
CDS	1277..1540
Translation	MLLLYLGIEVIRLFFGTKGNLCQRKMPLSISVALTFPSAMMASYYLLLQTYVLRLEAIMNGILLFFCGSELLLEVLTLAAFSSMDRI

Target ORF information:

RefSeq Version	XM_005274039.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 216 (TMEM216), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005274039.3

ORF Insert Sequence:

ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG 
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT 
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT 
TTCTCCAGTA TGGACAGGAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.
Nature cell biology18(1)122-31(2016 Jan)
Lambacher NJ,Bruel AL,van Dam TJ,Szymańska K,Slaats GG,Kuhns S,McManus GJ,Kennedy JE,Gaff K,Wu KM,van der Lee R,Burglen L,Doummar D,Rivière JB,Faivre L,Attié-Bitach T,Saunier S,Curd A,Peckham M,Giles RH,Johnson CA,Huynen MA,Thauvin-Robinet C,Blacque OE

Evolutionarily assembled cis-regulatory module at a human ciliopathy locus.
Science (New York, N.Y.)335(6071)966-9(2012 Feb)
Lee JH,Silhavy JL,Lee JE,Al-Gazali L,Thomas S,Davis EE,Bielas SL,Hill KJ,Iannicelli M,Brancati F,Gabriel SB,Russ C,Logan CV,Sharif SM,Bennett CP,Abe M,Hildebrandt F,Diplas BH,Attié-Bitach T,Katsanis N,Rajab A,Koul R,Sztriha L,Waters ER,Ferro-Novick S,Woods CG,Johnson CA,Valente EM,Zaki MS,Gleeson JG

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.
Journal of medical genetics48(2)105-16(2011 Feb)
Otto EA,Ramaswami G,Janssen S,Chaki M,Allen SJ,Zhou W,Airik R,Hurd TW,Ghosh AK,Wolf MT,Hoppe B,Neuhaus TJ,Bockenhauer D,Milford DV,Soliman NA,Antignac C,Saunier S,Johnson CA,Hildebrandt F,

Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes.
Nature genetics42(7)619-25(2010 Jul)
Valente EM,Logan CV,Mougou-Zerelli S,Lee JH,Silhavy JL,Brancati F,Iannicelli M,Travaglini L,Romani S,Illi B,Adams M,Szymanska K,Mazzotta A,Lee JE,Tolentino JC,Swistun D,Salpietro CD,Fede C,Gabriel S,Russ C,Cibulskis K,Sougnez C,Hildebrandt F,Otto EA,Held S,Diplas BH,Davis EE,Mikula M,Strom CM,Ben-Zeev B,Lev D,Sagie TL,Michelson M,Yaron Y,Krause A,Boltshauser E,Elkhartoufi N,Roume J,Shalev S,Munnich A,Saunier S,Inglehearn C,Saad A,Alkindy A,Thomas S,Vekemans M,Dallapiccola B,Katsanis N,Johnson CA,Attié-Bitach T,Gleeson JG

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TMEM216 cDNA ORF clone, Homo sapiens(human)

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