| Gene Symbol | ATOH1 |
| Entrez Gene ID | 474 |
| Full Name | atonal bHLH transcription factor 1 |
| Synonyms | ATH1,HATH1,MATH-1,bHLHa14 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
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ATOH1 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following ATOH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATOH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu29710 Clone ID Related Accession (Same CDS sequence) NM_005172.1 , NM_005172.2 Accession Version NM_005172.1 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1065bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1535126400000 Organism Homo sapiens(human) Product protein atonal homolog 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U61148.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069594.1, BC069145.1 [ECO:0000345] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021ATGTCCCGCC TGCTGCATGC AGAAGAGTGG GCTGAAGTGA AGGAGTTGGG AGACCACCAT
CGCCAGCCCC AGCCGCATCA TCTCCCGCAA CCGCCGCCGC CGCCGCAGCC ACCTGCAACT
TTGCAGGCGA GAGAGCATCC CGTCTACCCG CCTGAGCTGT CCCTCCTGGA CAGCACCGAC
CCACGCGCCT GGCTGGCTCC CACTTTGCAG GGCATCTGCA CGGCACGCGC CGCCCAGTAT
TTGCTACATT CCCCGGAGCT GGGTGCCTCA GAGGCCGCTG CGCCCCGGGA CGAGGTGGAC
GGCCGGGGGG AGCTGGTAAG GAGGAGCAGC GGCGGTGCCA GCAGCAGCAA GAGCCCCGGG
CCGGTGAAAG TGCGGGAACA GCTGTGCAAG CTGAAAGGCG GGGTGGTGGT AGACGAGCTG
GGCTGCAGCC GCCAACGGGC CCCTTCCAGC AAACAGGTGA ATGGGGTGCA GAAGCAGAGA
CGGCTAGCAG CCAACGCCAG GGAGCGGCGC AGGATGCATG GGCTGAACCA CGCCTTCGAC
CAGCTGCGCA ATGTTATCCC GTCGTTCAAC AACGACAAGA AGCTGTCCAA ATATGAGACC
CTGCAGATGG CCCAAATCTA CATCAACGCC TTGTCCGAGC TGCTACAAAC GCCCAGCGGA
GGGGAACAGC CACCGCCGCC TCCAGCCTCC TGCAAAAGCG ACCACCACCA CCTTCGCACC
GCGGCCTCCT ATGAAGGGGG CGCGGGCAAC GCGACCGCAG CTGGGGCTCA GCAGGCTTCC
GGAGGGAGCC AGCGGCCGAC CCCGCCCGGG AGTTGCCGGA CTCGCTTCTC AGCCCCAGCT
TCTGCGGGAG GGTACTCGGT GCAGCTGGAC GCTCTGCACT TCTCGACTTT CGAGGACAGC
GCCCTGACAG CGATGATGGC GCAAAAGAAT TTGTCTCCTT CTCTCCCCGG GAGCATCTTG
CAGCCAGTGC AGGAGGAAAA CAGCAAAACT TCGCCTCGGT CCCACAGAAG CGACGGGGAA
TTTTCCCCCC ATTCCCATTA CAGTGACTCG GATGAGGCAA GTTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_005163.1 CDS 1..1065 Translation 
Target ORF information:
RefSeq Version NM_005172.1 Organism Homo sapiens(human) Definition Homo sapiens atonal bHLH transcription factor 1 (ATOH1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_005172.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021ATGTCCCGCC TGCTGCATGC AGAAGAGTGG GCTGAAGTGA AGGAGTTGGG AGACCACCAT
CGCCAGCCCC AGCCGCATCA TCTCCCGCAA CCGCCGCCGC CGCCGCAGCC ACCTGCAACT
TTGCAGGCGA GAGAGCATCC CGTCTACCCG CCTGAGCTGT CCCTCCTGGA CAGCACCGAC
CCACGCGCCT GGCTGGCTCC CACTTTGCAG GGCATCTGCA CGGCACGCGC CGCCCAGTAT
TTGCTACATT CCCCGGAGCT GGGTGCCTCA GAGGCCGCTG CGCCCCGGGA CGAGGTGGAC
GGCCGGGGGG AGCTGGTAAG GAGGAGCAGC GGCGGTGCCA GCAGCAGCAA GAGCCCCGGG
CCGGTGAAAG TGCGGGAACA GCTGTGCAAG CTGAAAGGCG GGGTGGTGGT AGACGAGCTG
GGCTGCAGCC GCCAACGGGC CCCTTCCAGC AAACAGGTGA ATGGGGTGCA GAAGCAGAGA
CGGCTAGCAG CCAACGCCAG GGAGCGGCGC AGGATGCATG GGCTGAACCA CGCCTTCGAC
CAGCTGCGCA ATGTTATCCC GTCGTTCAAC AACGACAAGA AGCTGTCCAA ATATGAGACC
CTGCAGATGG CCCAAATCTA CATCAACGCC TTGTCCGAGC TGCTACAAAC GCCCAGCGGA
GGGGAACAGC CACCGCCGCC TCCAGCCTCC TGCAAAAGCG ACCACCACCA CCTTCGCACC
GCGGCCTCCT ATGAAGGGGG CGCGGGCAAC GCGACCGCAG CTGGGGCTCA GCAGGCTTCC
GGAGGGAGCC AGCGGCCGAC CCCGCCCGGG AGTTGCCGGA CTCGCTTCTC AGCCCCAGCT
TCTGCGGGAG GGTACTCGGT GCAGCTGGAC GCTCTGCACT TCTCGACTTT CGAGGACAGC
GCCCTGACAG CGATGATGGC GCAAAAGAAT TTGTCTCCTT CTCTCCCCGG GAGCATCTTG
CAGCCAGTGC AGGAGGAAAA CAGCAAAACT TCGCCTCGGT CCCACAGAAG CGACGGGGAA
TTTTCCCCCC ATTCCCATTA CAGTGACTCG GATGAGGCAA GTTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu29710 Clone ID Related Accession (Same CDS sequence) NM_005172.1 , NM_005172.2 Accession Version NM_005172.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1065bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1565107200000 Organism Homo sapiens(human) Product protein atonal homolog 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087413.5 and BC113625.1. On May 17, 2019 this sequence version replaced NM_005172.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC113623.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021ATGTCCCGCC TGCTGCATGC AGAAGAGTGG GCTGAAGTGA AGGAGTTGGG AGACCACCAT
CGCCAGCCCC AGCCGCATCA TCTCCCGCAA CCGCCGCCGC CGCCGCAGCC ACCTGCAACT
TTGCAGGCGA GAGAGCATCC CGTCTACCCG CCTGAGCTGT CCCTCCTGGA CAGCACCGAC
CCACGCGCCT GGCTGGCTCC CACTTTGCAG GGCATCTGCA CGGCACGCGC CGCCCAGTAT
TTGCTACATT CCCCGGAGCT GGGTGCCTCA GAGGCCGCTG CGCCCCGGGA CGAGGTGGAC
GGCCGGGGGG AGCTGGTAAG GAGGAGCAGC GGCGGTGCCA GCAGCAGCAA GAGCCCCGGG
CCGGTGAAAG TGCGGGAACA GCTGTGCAAG CTGAAAGGCG GGGTGGTGGT AGACGAGCTG
GGCTGCAGCC GCCAACGGGC CCCTTCCAGC AAACAGGTGA ATGGGGTGCA GAAGCAGAGA
CGGCTAGCAG CCAACGCCAG GGAGCGGCGC AGGATGCATG GGCTGAACCA CGCCTTCGAC
CAGCTGCGCA ATGTTATCCC GTCGTTCAAC AACGACAAGA AGCTGTCCAA ATATGAGACC
CTGCAGATGG CCCAAATCTA CATCAACGCC TTGTCCGAGC TGCTACAAAC GCCCAGCGGA
GGGGAACAGC CACCGCCGCC TCCAGCCTCC TGCAAAAGCG ACCACCACCA CCTTCGCACC
GCGGCCTCCT ATGAAGGGGG CGCGGGCAAC GCGACCGCAG CTGGGGCTCA GCAGGCTTCC
GGAGGGAGCC AGCGGCCGAC CCCGCCCGGG AGTTGCCGGA CTCGCTTCTC AGCCCCAGCT
TCTGCGGGAG GGTACTCGGT GCAGCTGGAC GCTCTGCACT TCTCGACTTT CGAGGACAGC
GCCCTGACAG CGATGATGGC GCAAAAGAAT TTGTCTCCTT CTCTCCCCGG GAGCATCTTG
CAGCCAGTGC AGGAGGAAAA CAGCAAAACT TCGCCTCGGT CCCACAGAAG CGACGGGGAA
TTTTCCCCCC ATTCCCATTA CAGTGACTCG GATGAGGCAA GTTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_005163.1 CDS 175..1239 Translation
Target ORF information:
RefSeq Version NM_005172.2 Organism Homo sapiens(human) Definition Homo sapiens atonal bHLH transcription factor 1 (ATOH1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_005172.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021ATGTCCCGCC TGCTGCATGC AGAAGAGTGG GCTGAAGTGA AGGAGTTGGG AGACCACCAT
CGCCAGCCCC AGCCGCATCA TCTCCCGCAA CCGCCGCCGC CGCCGCAGCC ACCTGCAACT
TTGCAGGCGA GAGAGCATCC CGTCTACCCG CCTGAGCTGT CCCTCCTGGA CAGCACCGAC
CCACGCGCCT GGCTGGCTCC CACTTTGCAG GGCATCTGCA CGGCACGCGC CGCCCAGTAT
TTGCTACATT CCCCGGAGCT GGGTGCCTCA GAGGCCGCTG CGCCCCGGGA CGAGGTGGAC
GGCCGGGGGG AGCTGGTAAG GAGGAGCAGC GGCGGTGCCA GCAGCAGCAA GAGCCCCGGG
CCGGTGAAAG TGCGGGAACA GCTGTGCAAG CTGAAAGGCG GGGTGGTGGT AGACGAGCTG
GGCTGCAGCC GCCAACGGGC CCCTTCCAGC AAACAGGTGA ATGGGGTGCA GAAGCAGAGA
CGGCTAGCAG CCAACGCCAG GGAGCGGCGC AGGATGCATG GGCTGAACCA CGCCTTCGAC
CAGCTGCGCA ATGTTATCCC GTCGTTCAAC AACGACAAGA AGCTGTCCAA ATATGAGACC
CTGCAGATGG CCCAAATCTA CATCAACGCC TTGTCCGAGC TGCTACAAAC GCCCAGCGGA
GGGGAACAGC CACCGCCGCC TCCAGCCTCC TGCAAAAGCG ACCACCACCA CCTTCGCACC
GCGGCCTCCT ATGAAGGGGG CGCGGGCAAC GCGACCGCAG CTGGGGCTCA GCAGGCTTCC
GGAGGGAGCC AGCGGCCGAC CCCGCCCGGG AGTTGCCGGA CTCGCTTCTC AGCCCCAGCT
TCTGCGGGAG GGTACTCGGT GCAGCTGGAC GCTCTGCACT TCTCGACTTT CGAGGACAGC
GCCCTGACAG CGATGATGGC GCAAAAGAAT TTGTCTCCTT CTCTCCCCGG GAGCATCTTG
CAGCCAGTGC AGGAGGAAAA CAGCAAAACT TCGCCTCGGT CCCACAGAAG CGACGGGGAA
TTTTCCCCCC ATTCCCATTA CAGTGACTCG GATGAGGCAA GTTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Atoh1 and other related key regulators in the development of auditory sensory epithelium in the mammalian inner ear: function and interplay.
Developmental biology446(2)133-141(2019 02)
Zhong C,Fu Y,Pan W,Yu J,Wang J
Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.
Developmental cell48(2)184-199.e5(2019 01)
Chang CH,Zanini M,Shirvani H,Cheng JS,Yu H,Feng CH,Mercier AL,Hung SY,Forget A,Wang CH,Cigna SM,Lu IL,Chen WY,Leboucher S,Wang WJ,Ruat M,Spassky N,Tsai JW,Ayrault O
MicroRNA-613 promotes colon cancer cell proliferation, invasion and migration by targeting ATOH1.
Biochemical and biophysical research communications504(4)827-833(2018 10)
Yang X,Zhang L,Song X,He W,Zhang D,Lu Q,Wu J,Wu C,Jiang J
Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals.
Oncology reports39(4)1930-1938(2018 Apr)
Park JH,Lee JM,Lee EJ,Kim DJ,Hwang WB
Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.
eLife6(2017 11)
Klisch TJ,Vainshtein A,Patel AJ,Zoghbi HY
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