MYBPC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYBPC3
Entrez Gene ID	4607
Full Name	myosin binding protein C, cardiac
Synonyms	CMD1MM,CMH4,FHC,LVNC10,MYBP-C
General protein information	Preferred Names myosin binding protein C, cardiac Names myosin-binding protein C, cardiac-type C-protein, cardiac muscle isoform truncated cardiac myosin-binding protein C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p11.2
Summary	MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008].
Disorder MIM:	600958
Disorder Html:	Cardiomyopathy, hypertrophic, 4, 115197 (3); Cardiomyopathy, dilated, 1MM, 615396 (3); Left ventricular noncompaction 10, 615396 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000256.3	NP_000247.2	myosin-binding protein C, cardiac-type

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	MYBPC3	XP_002808117.1
Bos taurus (cattle)	MYBPC3	NP_001070004.1
Xenopus tropicalis (tropical clawed frog)	mybpc3	NP_001106379.1
Homo sapiens (human)	MYBPC3	NP_000247.2
Rattus norvegicus (Norway rat)	Mybpc3	NP_001099960.1
Danio rerio (zebrafish)	mybpc3	NP_001037814.2
Canis lupus familiaris (dog)	MYBPC3	NP_001041571.1
Mus musculus (house mouse)	Mybpc3	NP_032679.2
Gallus gallus (chicken)	MYBPC3	NP_990447.1
Pan troglodytes (chimpanzee)	MYBPC3	XP_508410.4

Gene Ontology
Bibliography

Related articles in PubMed

Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding.
Inchingolo AV, Previs SB, Previs MJ, Warshaw DM, Kad NM
Proceedings of the National Academy of Sciences of the United States of America116(14)6828-6835(2019 04)

Molecular characterization of Portuguese patients with dilated cardiomyopathy.
Sousa A, Canedo P, Azevedo O, Lopes L, Pinho T, Baixia M, Rocha-Gonçalves F, Gonçalves L, Cardoso JS, Machado JC, Martins E,
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology38(2)129-139(2019 02)

A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay.
Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC
Circulation139(6)799-811(2019 02)

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction.
Da'as SI, Fakhro K, Thanassoulas A, Krishnamoorthy N, Saleh A, Calver BL, Safieh-Garabedian B, Toft E, Nounesis G, Lai FA, Nomikos M
The Biochemical journal475(24)3933-3948(2018 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MYBPC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYBPC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu27085	NM_000256.3 Latest version!	Homo sapiens myosin binding protein C3 (MYBPC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$643.30 $919.00

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYBPC3 ( NM_000256.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000247.2 Homo sapiens myosin binding protein C3 (MYBPC3), mRNA.

Price & Availability↑

CloneID	OHu27085
Clone ID Related Accession (Same CDS sequence)	NM_000256.3
Accession Version	NM_000256.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Homo sapiens(human)
Product	myosin-binding protein C, cardiac-type
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EF560722.1, AU140784.1, AJ708511.1, AL691822.1, DA563514.1 and AJ708699.1. This sequence is a reference standard in the RefSeqGene project. On Jun 5, 2007 this sequence version replaced NM_000256.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU747718.1, EU747719.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000545968.6/ ENSP00000442795.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTGAGC CGGGGAAGAA GCCAGTCTCA GCTTTTAGCA AGAAGCCACG GTCAGTGGAA 
GTGGCCGCAG GCAGCCCTGC CGTGTTCGAG GCCGAGACAG AGCGGGCAGG AGTGAAGGTG 
CGCTGGCAGC GCGGAGGCAG TGACATCAGC GCCAGCAACA AGTACGGCCT GGCCACAGAG 
GGCACACGGC ATACGCTGAC AGTGCGGGAA GTGGGCCCTG CCGACCAGGG ATCTTACGCA 
GTCATTGCTG GCTCCTCCAA GGTCAAGTTC GACCTCAAGG TCATAGAGGC AGAGAAGGCA 
GAGCCCATGC TGGCCCCTGC CCCTGCCCCT GCTGAGGCCA CTGGAGCCCC TGGAGAAGCC 
CCGGCCCCAG CCGCTGAGCT GGGAGAAAGT GCCCCAAGTC CCAAAGGGTC AAGCTCAGCA 
GCTCTCAATG GTCCTACCCC TGGAGCCCCC GATGACCCCA TTGGCCTCTT CGTGATGCGG 
CCACAGGATG GCGAGGTGAC CGTGGGTGGC AGCATCACCT TCTCAGCCCG CGTGGCCGGC 
GCCAGCCTCC TGAAGCCGCC TGTGGTCAAG TGGTTCAAGG GCAAATGGGT GGACCTGAGC 
AGCAAGGTGG GCCAGCACCT GCAGCTGCAC GACAGCTACG ACCGCGCCAG CAAGGTCTAT 
CTGTTCGAGC TGCACATCAC CGATGCCCAG CCTGCCTTCA CTGGCAGCTA CCGCTGTGAG 
GTGTCCACCA AGGACAAATT TGACTGCTCC AACTTCAATC TCACTGTCCA CGAGGCCATG 
GGCACCGGAG ACCTGGACCT CCTATCAGCC TTCCGCCGCA CGAGCCTGGC TGGAGGTGGT 
CGGCGGATCA GTGATAGCCA TGAGGACACT GGGATTCTGG ACTTCAGCTC ACTGCTGAAA 
AAGAGAGACA GTTTCCGGAC CCCGAGGGAC TCGAAGCTGG AGGCACCAGC AGAGGAGGAC 
GTGTGGGAGA TCCTACGGCA GGCACCCCCA TCTGAGTACG AGCGCATCGC CTTCCAGTAC 
GGCGTCACTG ACCTGCGCGG CATGCTAAAG AGGCTCAAGG GCATGAGGCG CGATGAGAAG 
AAGAGCACAG CCTTTCAGAA GAAGCTGGAG CCGGCCTACC AGGTGAGCAA AGGCCACAAG 
ATCCGGCTGA CCGTGGAACT GGCTGACCAT GACGCTGAGG TCAAATGGCT CAAGAATGGC 
CAGGAGATCC AGATGAGCGG CAGCAAGTAC ATCTTTGAGT CCATCGGTGC CAAGCGTACC 
CTGACCATCA GCCAGTGCTC ATTGGCGGAC GACGCAGCCT ACCAGTGCGT GGTGGGTGGC 
GAGAAGTGTA GCACGGAGCT CTTTGTGAAA GAGCCCCCTG TGCTCATCAC GCGCCCCTTG 
GAGGACCAGC TGGTGATGGT GGGGCAGCGG GTGGAGTTTG AGTGTGAAGT ATCGGAGGAG 
GGGGCGCAAG TCAAATGGCT GAAGGACGGG GTGGAGCTGA CCCGGGAGGA GACCTTCAAA 
TACCGGTTCA AGAAGGACGG GCAGAGACAC CACCTGATCA TCAACGAGGC CATGCTGGAG 
GACGCGGGGC ACTATGCACT GTGCACTAGC GGGGGCCAGG CGCTGGCTGA GCTCATTGTG 
CAGGAAAAGA AGCTGGAGGT GTACCAGAGC ATCGCAGACC TGATGGTGGG CGCAAAGGAC 
CAGGCGGTGT TCAAATGTGA GGTCTCAGAT GAGAATGTTC GGGGTGTGTG GCTGAAGAAT 
GGGAAGGAGC TGGTGCCCGA CAGCCGCATA AAGGTGTCCC ACATCGGGCG GGTCCACAAA 
CTGACCATTG ACGACGTCAC ACCTGCCGAC GAGGCTGACT ACAGCTTTGT GCCCGAGGGC 
TTCGCCTGCA ACCTGTCAGC CAAGCTCCAC TTCATGGAGG TCAAGATTGA CTTCGTACCC 
AGGCAGGAAC CTCCCAAGAT CCACCTGGAC TGCCCAGGCC GCATACCAGA CACCATTGTG 
GTTGTAGCTG GAAATAAGCT ACGTCTGGAC GTCCCTATCT CTGGGGACCC TGCTCCCACT 
GTGATCTGGC AGAAGGCTAT CACGCAGGGG AATAAGGCCC CAGCCAGGCC AGCCCCAGAT 
GCCCCAGAGG ACACAGGTGA CAGCGATGAG TGGGTGTTTG ACAAGAAGCT GCTGTGTGAG 
ACCGAGGGCC GGGTCCGCGT GGAGACCACC AAGGACCGCA GCATCTTCAC GGTCGAGGGG 
GCAGAGAAGG AAGATGAGGG CGTCTACACG GTCACAGTGA AGAACCCTGT GGGCGAGGAC 
CAGGTCAACC TCACAGTCAA GGTCATCGAC GTGCCAGACG CACCTGCGGC CCCCAAGATC 
AGCAACGTGG GAGAGGACTC CTGCACAGTA CAGTGGGAGC CGCCTGCCTA CGATGGCGGG 
CAGCCCATCC TGGGCTACAT CCTGGAGCGC AAGAAGAAGA AGAGCTACCG GTGGATGCGG 
CTGAACTTCG ACCTGATTCA GGAGCTGAGT CATGAAGCGC GGCGCATGAT CGAGGGCGTG 
GTGTACGAGA TGCGCGTCTA CGCGGTCAAC GCCATCGGCA TGTCCAGGCC CAGCCCTGCC 
TCCCAGCCCT TCATGCCTAT CGGTCCCCCC AGCGAACCCA CCCACCTGGC AGTAGAGGAC 
GTCTCTGACA CCACGGTCTC CCTCAAGTGG CGGCCCCCAG AGCGCGTGGG AGCAGGAGGC 
CTGGATGGCT ACAGCGTGGA GTACTGCCCA GAGGGCTGCT CAGAGTGGGT GGCTGCCCTG 
CAGGGGCTGA CAGAGCACAC ATCGATACTG GTGAAGGACC TGCCCACGGG GGCCCGGCTG 
CTTTTCCGAG TGCGGGCACA CAATATGGCA GGGCCTGGAG CCCCTGTTAC CACCACGGAG 
CCGGTGACAG TGCAGGAGAT CCTGCAACGG CCACGGCTTC AGCTGCCCAG GCACCTGCGC 
CAGACCATTC AGAAGAAGGT CGGGGAGCCT GTGAACCTTC TCATCCCTTT CCAGGGCAAG 
CCCCGGCCTC AGGTGACCTG GACCAAAGAG GGGCAGCCCC TGGCAGGCGA GGAGGTGAGC 
ATCCGCAACA GCCCCACAGA CACCATCCTG TTCATCCGGG CCGCTCGCCG CGTGCATTCA 
GGCACTTACC AGGTGACGGT GCGCATTGAG AACATGGAGG ACAAGGCCAC GCTGGTGCTG 
CAGGTTGTTG ACAAGCCAAG TCCTCCCCAG GATCTCCGGG TGACTGACGC CTGGGGTCTT 
AATGTGGCTC TGGAGTGGAA GCCACCCCAG GATGTCGGCA ACACGGAGCT CTGGGGGTAC 
ACAGTGCAGA AAGCCGACAA GAAGACCATG GAGTGGTTCA CCGTCTTGGA GCATTACCGC 
CGCACCCACT GCGTGGTGCC AGAGCTCATC ATTGGCAATG GCTACTACTT CCGCGTCTTC 
AGCCAGAATA TGGTTGGCTT TAGTGACAGA GCGGCCACCA CCAAGGAGCC CGTCTTTATC 
CCCAGACCAG GCATCACCTA TGAGCCACCC AACTATAAGG CCCTGGACTT CTCCGAGGCC 
CCAAGCTTCA CCCAGCCCCT GGTGAACCGC TCGGTCATCG CGGGCTACAC TGCTATGCTC 
TGCTGTGCTG TCCGGGGTAG CCCCAAGCCC AAGATTTCCT GGTTCAAGAA TGGCCTGGAC 
CTGGGAGAAG ACGCCCGCTT CCGCATGTTC AGCAAGCAGG GAGTGTTGAC TCTGGAGATT 
AGAAAGCCCT GCCCCTTTGA CGGGGGCATC TATGTCTGCA GGGCCACCAA CTTACAGGGC 
GAGGCACGGT GTGAGTGCCG CCTGGAGGTG CGAGTGCCTC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000247.2
CDS	56..3880
Translation	MPEPGKKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSYAVIAGSSKVKFDLKVIEAEKAEPMLAPAPAPAEATGAPGEAPAPAAELGESAPSPKGSSSAALNGPTPGAPDDPIGLFVMRPQDGEVTVGGSITFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASKVYLFELHITDAQPAFTGSYRCEVSTKDKFDCSNFNLTVHEAMGTGDLDLLSAFRRTSLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQAPPSEYERIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNKAPARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPGAPVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTILFIRAARRVHSGTYQVTVRIENMEDKATLVLQVVDKPSPPQDLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPRPGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVPQ

Target ORF information:

RefSeq Version	NM_000256.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin binding protein C3 (MYBPC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000256.3

ORF Insert Sequence:

ATGCCTGAGC CGGGGAAGAA GCCAGTCTCA GCTTTTAGCA AGAAGCCACG GTCAGTGGAA 
GTGGCCGCAG GCAGCCCTGC CGTGTTCGAG GCCGAGACAG AGCGGGCAGG AGTGAAGGTG 
CGCTGGCAGC GCGGAGGCAG TGACATCAGC GCCAGCAACA AGTACGGCCT GGCCACAGAG 
GGCACACGGC ATACGCTGAC AGTGCGGGAA GTGGGCCCTG CCGACCAGGG ATCTTACGCA 
GTCATTGCTG GCTCCTCCAA GGTCAAGTTC GACCTCAAGG TCATAGAGGC AGAGAAGGCA 
GAGCCCATGC TGGCCCCTGC CCCTGCCCCT GCTGAGGCCA CTGGAGCCCC TGGAGAAGCC 
CCGGCCCCAG CCGCTGAGCT GGGAGAAAGT GCCCCAAGTC CCAAAGGGTC AAGCTCAGCA 
GCTCTCAATG GTCCTACCCC TGGAGCCCCC GATGACCCCA TTGGCCTCTT CGTGATGCGG 
CCACAGGATG GCGAGGTGAC CGTGGGTGGC AGCATCACCT TCTCAGCCCG CGTGGCCGGC 
GCCAGCCTCC TGAAGCCGCC TGTGGTCAAG TGGTTCAAGG GCAAATGGGT GGACCTGAGC 
AGCAAGGTGG GCCAGCACCT GCAGCTGCAC GACAGCTACG ACCGCGCCAG CAAGGTCTAT 
CTGTTCGAGC TGCACATCAC CGATGCCCAG CCTGCCTTCA CTGGCAGCTA CCGCTGTGAG 
GTGTCCACCA AGGACAAATT TGACTGCTCC AACTTCAATC TCACTGTCCA CGAGGCCATG 
GGCACCGGAG ACCTGGACCT CCTATCAGCC TTCCGCCGCA CGAGCCTGGC TGGAGGTGGT 
CGGCGGATCA GTGATAGCCA TGAGGACACT GGGATTCTGG ACTTCAGCTC ACTGCTGAAA 
AAGAGAGACA GTTTCCGGAC CCCGAGGGAC TCGAAGCTGG AGGCACCAGC AGAGGAGGAC 
GTGTGGGAGA TCCTACGGCA GGCACCCCCA TCTGAGTACG AGCGCATCGC CTTCCAGTAC 
GGCGTCACTG ACCTGCGCGG CATGCTAAAG AGGCTCAAGG GCATGAGGCG CGATGAGAAG 
AAGAGCACAG CCTTTCAGAA GAAGCTGGAG CCGGCCTACC AGGTGAGCAA AGGCCACAAG 
ATCCGGCTGA CCGTGGAACT GGCTGACCAT GACGCTGAGG TCAAATGGCT CAAGAATGGC 
CAGGAGATCC AGATGAGCGG CAGCAAGTAC ATCTTTGAGT CCATCGGTGC CAAGCGTACC 
CTGACCATCA GCCAGTGCTC ATTGGCGGAC GACGCAGCCT ACCAGTGCGT GGTGGGTGGC 
GAGAAGTGTA GCACGGAGCT CTTTGTGAAA GAGCCCCCTG TGCTCATCAC GCGCCCCTTG 
GAGGACCAGC TGGTGATGGT GGGGCAGCGG GTGGAGTTTG AGTGTGAAGT ATCGGAGGAG 
GGGGCGCAAG TCAAATGGCT GAAGGACGGG GTGGAGCTGA CCCGGGAGGA GACCTTCAAA 
TACCGGTTCA AGAAGGACGG GCAGAGACAC CACCTGATCA TCAACGAGGC CATGCTGGAG 
GACGCGGGGC ACTATGCACT GTGCACTAGC GGGGGCCAGG CGCTGGCTGA GCTCATTGTG 
CAGGAAAAGA AGCTGGAGGT GTACCAGAGC ATCGCAGACC TGATGGTGGG CGCAAAGGAC 
CAGGCGGTGT TCAAATGTGA GGTCTCAGAT GAGAATGTTC GGGGTGTGTG GCTGAAGAAT 
GGGAAGGAGC TGGTGCCCGA CAGCCGCATA AAGGTGTCCC ACATCGGGCG GGTCCACAAA 
CTGACCATTG ACGACGTCAC ACCTGCCGAC GAGGCTGACT ACAGCTTTGT GCCCGAGGGC 
TTCGCCTGCA ACCTGTCAGC CAAGCTCCAC TTCATGGAGG TCAAGATTGA CTTCGTACCC 
AGGCAGGAAC CTCCCAAGAT CCACCTGGAC TGCCCAGGCC GCATACCAGA CACCATTGTG 
GTTGTAGCTG GAAATAAGCT ACGTCTGGAC GTCCCTATCT CTGGGGACCC TGCTCCCACT 
GTGATCTGGC AGAAGGCTAT CACGCAGGGG AATAAGGCCC CAGCCAGGCC AGCCCCAGAT 
GCCCCAGAGG ACACAGGTGA CAGCGATGAG TGGGTGTTTG ACAAGAAGCT GCTGTGTGAG 
ACCGAGGGCC GGGTCCGCGT GGAGACCACC AAGGACCGCA GCATCTTCAC GGTCGAGGGG 
GCAGAGAAGG AAGATGAGGG CGTCTACACG GTCACAGTGA AGAACCCTGT GGGCGAGGAC 
CAGGTCAACC TCACAGTCAA GGTCATCGAC GTGCCAGACG CACCTGCGGC CCCCAAGATC 
AGCAACGTGG GAGAGGACTC CTGCACAGTA CAGTGGGAGC CGCCTGCCTA CGATGGCGGG 
CAGCCCATCC TGGGCTACAT CCTGGAGCGC AAGAAGAAGA AGAGCTACCG GTGGATGCGG 
CTGAACTTCG ACCTGATTCA GGAGCTGAGT CATGAAGCGC GGCGCATGAT CGAGGGCGTG 
GTGTACGAGA TGCGCGTCTA CGCGGTCAAC GCCATCGGCA TGTCCAGGCC CAGCCCTGCC 
TCCCAGCCCT TCATGCCTAT CGGTCCCCCC AGCGAACCCA CCCACCTGGC AGTAGAGGAC 
GTCTCTGACA CCACGGTCTC CCTCAAGTGG CGGCCCCCAG AGCGCGTGGG AGCAGGAGGC 
CTGGATGGCT ACAGCGTGGA GTACTGCCCA GAGGGCTGCT CAGAGTGGGT GGCTGCCCTG 
CAGGGGCTGA CAGAGCACAC ATCGATACTG GTGAAGGACC TGCCCACGGG GGCCCGGCTG 
CTTTTCCGAG TGCGGGCACA CAATATGGCA GGGCCTGGAG CCCCTGTTAC CACCACGGAG 
CCGGTGACAG TGCAGGAGAT CCTGCAACGG CCACGGCTTC AGCTGCCCAG GCACCTGCGC 
CAGACCATTC AGAAGAAGGT CGGGGAGCCT GTGAACCTTC TCATCCCTTT CCAGGGCAAG 
CCCCGGCCTC AGGTGACCTG GACCAAAGAG GGGCAGCCCC TGGCAGGCGA GGAGGTGAGC 
ATCCGCAACA GCCCCACAGA CACCATCCTG TTCATCCGGG CCGCTCGCCG CGTGCATTCA 
GGCACTTACC AGGTGACGGT GCGCATTGAG AACATGGAGG ACAAGGCCAC GCTGGTGCTG 
CAGGTTGTTG ACAAGCCAAG TCCTCCCCAG GATCTCCGGG TGACTGACGC CTGGGGTCTT 
AATGTGGCTC TGGAGTGGAA GCCACCCCAG GATGTCGGCA ACACGGAGCT CTGGGGGTAC 
ACAGTGCAGA AAGCCGACAA GAAGACCATG GAGTGGTTCA CCGTCTTGGA GCATTACCGC 
CGCACCCACT GCGTGGTGCC AGAGCTCATC ATTGGCAATG GCTACTACTT CCGCGTCTTC 
AGCCAGAATA TGGTTGGCTT TAGTGACAGA GCGGCCACCA CCAAGGAGCC CGTCTTTATC 
CCCAGACCAG GCATCACCTA TGAGCCACCC AACTATAAGG CCCTGGACTT CTCCGAGGCC 
CCAAGCTTCA CCCAGCCCCT GGTGAACCGC TCGGTCATCG CGGGCTACAC TGCTATGCTC 
TGCTGTGCTG TCCGGGGTAG CCCCAAGCCC AAGATTTCCT GGTTCAAGAA TGGCCTGGAC 
CTGGGAGAAG ACGCCCGCTT CCGCATGTTC AGCAAGCAGG GAGTGTTGAC TCTGGAGATT 
AGAAAGCCCT GCCCCTTTGA CGGGGGCATC TATGTCTGCA GGGCCACCAA CTTACAGGGC 
GAGGCACGGT GTGAGTGCCG CCTGGAGGTG CGAGTGCCTC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding.
Proceedings of the National Academy of Sciences of the United States of America116(14)6828-6835(2019 04)
Inchingolo AV,Previs SB,Previs MJ,Warshaw DM,Kad NM

Molecular characterization of Portuguese patients with dilated cardiomyopathy.
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology38(2)129-139(2019 02)
Sousa A,Canedo P,Azevedo O,Lopes L,Pinho T,Baixia M,Rocha-Gonçalves F,Gonçalves L,Cardoso JS,Machado JC,Martins E,

A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay.
Circulation139(6)799-811(2019 02)
Seeger T,Shrestha R,Lam CK,Chen C,McKeithan WL,Lau E,Wnorowski A,McMullen G,Greenhaw M,Lee J,Oikonomopoulos A,Lee S,Yang H,Mercola M,Wheeler M,Ashley EA,Yang F,Karakikes I,Wu JC

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction.
The Biochemical journal475(24)3933-3948(2018 12)
Da'as SI,Fakhro K,Thanassoulas A,Krishnamoorthy N,Saleh A,Calver BL,Safieh-Garabedian B,Toft E,Nounesis G,Lai FA,Nomikos M

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MYBPC3 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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