MSX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MSX2
Entrez Gene ID	4488
Full Name	msh homeobox 2
Synonyms	CRS2,FPP,HOX8,MSH,PFM,PFM1
General protein information	Preferred Names msh homeobox 2 Names homeobox protein MSX-2 homeobox protein Hox-8 msh homeo box 2 msh homeobox homolog 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q35.2
Summary	This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008].
Disorder MIM:	123101
Disorder Html:	Craniosynostosis 2, 604757 (3); Parietal foramina 1, 168500 (3); Parietal foramina with cleidocranial dysplasia, 168550 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017009489.1	XP_016864978.1	homeobox protein MSX-2 isoform X1
NM_001363626.1	NP_001350555.1	homeobox protein MSX-2 isoform 2
NM_002449.4	NP_002440.2	homeobox protein MSX-2
NM_002449.5	NP_002440.2	homeobox protein MSX-2 isoform 1
NM_001363626.2	NP_001350555.1	homeobox protein MSX-2 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MSX2	NP_001129097.2
Bos taurus (cattle)	MSX2	NP_001073082.1
Rattus norvegicus (Norway rat)	Msx2	NP_037114.2
Mus musculus (house mouse)	Msx2	NP_038629.2
Gallus gallus (chicken)	MSX2	NP_989890.1
Homo sapiens (human)	MSX2	NP_002440.2
Macaca mulatta (Rhesus monkey)	MSX2	XP_001082405.1
Danio rerio (zebrafish)	msxd	NP_571351.2
Canis lupus familiaris (dog)	MSX2	NP_001003098.1
Xenopus tropicalis (tropical clawed frog)	msx2	XP_002936749.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of TGF-β1 Signaling in Heart Valve Calcification Induced by Abnormal Mechanical Stimulation in a Tissue Engineering Model.
Hu XJ, Wu WC, Dong NG, Shi JW, Liu JW, Chen S, Deng C, Shi F
Current medical science38(5)765-775(2018 Oct)

[A novel chemo-resistant gene MSX2 discovered by establishment of two pancreatic cancer drug resistant cell lines JF305/CDDP and PANC-1/GEM].
Yuan W, Sui CG, Ma X, Ma J
Zhonghua zhong liu za zhi [Chinese journal of oncology]40(5)330-334(2018 May)

Regulation of proliferation in developing human tooth germs by MSX homeodomain proteins and cyclin-dependent kinase inhibitor p19
Kero D, Vukojevic K, Stazic P, Sundov D, Mardesic Brakus S, Saraga-Babic M
Organogenesis13(4)141-155(2017 10)

Prognostic Relevance and Function of MSX2 in Colorectal Cancer.
Liu J, An H, Yuan W, Feng Q, Chen L, Ma J
Journal of diabetes research20173827037(2017)

MSX2 Induces Trophoblast Invasion in Human Placenta.
Liang H, Zhang Q, Lu J, Yang G, Tian N, Wang X, Tan Y, Tan D
PloS one11(4)e0153656(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MSX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu95891	NM_001363626.2 Latest version!	Homo sapiens msh homeobox 2 (MSX2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu95891	XM_017009489.1 Latest version!	Homo sapiens msh homeobox 2 (MSX2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu21502	NM_002449.5 Latest version!	Homo sapiens msh homeobox 2 (MSX2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
View Old Accession Versions >>
OHu21502	NM_002449.4	Homo sapiens msh homeobox 2 (MSX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
OHu95891	NM_001363626.1	Homo sapiens msh homeobox 2 (MSX2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MSX2 ( NM_001363626.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350555.1 Homo sapiens msh homeobox 2 (MSX2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu95891
Clone ID Related Accession (Same CDS sequence)	XM_017009489.1 , NM_001363626.1 , NM_001363626.2
Accession Version	NM_001363626.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1548432000000
Organism	Homo sapiens(human)
Product	homeobox protein MSX-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC117531.2. On May 24, 2018 this sequence version replaced XM_017009489.2. Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.159741.1, SRR1803612.409493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC 
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG 
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG 
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG 
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC 
CGATATTCGC CGCCGCCAAG TGAGTGCGCG CCGGGGCAGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350555.1
CDS	89..493
Translation	MASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEERRVKVSSLPFSVEALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPSECAPGQE

Target ORF information:

RefSeq Version	NM_001363626.1
Organism	Homo sapiens(human)
Definition	Homo sapiens msh homeobox 2 (MSX2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363626.1

ORF Insert Sequence:

ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC 
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG 
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG 
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG 
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC 
CGATATTCGC CGCCGCCAAG TGAGTGCGCG CCGGGGCAGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSX2 ( NM_001363626.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350555.1 Homo sapiens msh homeobox 2 (MSX2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu95891
Clone ID Related Accession (Same CDS sequence)	XM_017009489.1 , NM_001363626.1 , NM_001363626.2
Accession Version	NM_001363626.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577980800000
Organism	Homo sapiens(human)
Product	homeobox protein MSX-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC117531.2. On May 31, 2019 this sequence version replaced NM_001363626.1. Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.159741.1, SRR1803612.409493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC 
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG 
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG 
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG 
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC 
CGATATTCGC CGCCGCCAAG TGAGTGCGCG CCGGGGCAGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350555.1
CDS	79..483
Translation	MASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEERRVKVSSLPFSVEALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPSECAPGQE

Target ORF information:

RefSeq Version	NM_001363626.2
Organism	Homo sapiens(human)
Definition	Homo sapiens msh homeobox 2 (MSX2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363626.2

ORF Insert Sequence:

ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC 
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG 
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG 
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG 
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC 
CGATATTCGC CGCCGCCAAG TGAGTGCGCG CCGGGGCAGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSX2 ( XM_017009489.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864978.1 Homo sapiens msh homeobox 2 (MSX2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu95891
Clone ID Related Accession (Same CDS sequence)	XM_017009489.1 , NM_001363626.1 , NM_001363626.2
Accession Version	XM_017009489.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	homeobox protein MSX-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC 
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG 
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG 
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG 
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC 
CGATATTCGC CGCCGCCAAG TGAGTGCGCG CCGGGGCAGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864978.1
CDS	166..570
Translation	MASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEERRVKVSSLPFSVEALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPSECAPGQE

Target ORF information:

RefSeq Version	XM_017009489.1
Organism	Homo sapiens(human)
Definition	Homo sapiens msh homeobox 2 (MSX2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009489.1

ORF Insert Sequence:

ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC 
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG 
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG 
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG 
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC 
CGATATTCGC CGCCGCCAAG TGAGTGCGCG CCGGGGCAGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSX2 ( NM_002449.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002440.2 Homo sapiens msh homeobox 2 (MSX2), mRNA.

Price & Availability↑

CloneID	OHu21502
Clone ID Related Accession (Same CDS sequence)	NM_002449.4 , NM_002449.5
Accession Version	NM_002449.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Homo sapiens(human)
Product	homeobox protein MSX-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL552909.3, AC117531.2, W38629.1 and D89377.1. This sequence is a reference standard in the RefSeqGene project. On Jan 5, 2006 this sequence version replaced NM_002449.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D89377.1, SRR1660805.143303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC 
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG 
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG 
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG 
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC 
CGATATTCGC CGCCGCCAAG ACATATGAGC CCTACCACCT GCACCCTGAG GAAACACAAG 
ACCAATCGGA AGCCGCGCAC GCCCTTTACC ACATCCCAGC TCCTCGCCCT GGAGCGCAAG 
TTCCGTCAGA AACAGTACCT CTCCATTGCA GAGCGTGCAG AGTTCTCCAG CTCTCTGAAC 
CTCACAGAGA CCCAGGTCAA AATCTGGTTC CAGAACCGAA GGGCCAAGGC GAAAAGACTG 
CAGGAGGCAG AACTGGAAAA GCTGAAAATG GCTGCAAAAC CTATGCTGCC CTCCAGCTTC 
AGTCTCCCTT TCCCCATCAG CTCGCCCCTG CAGGCAGCGT CCATATATGG AGCATCCTAC 
CCGTTCCATA GACCTGTGCT TCCCATCCCG CCTGTGGGAC TCTATGCCAC GCCAGTGGGA 
TATGGCATGT ACCACCTGTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002440.2
CDS	89..892
Translation	MASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEERRVKVSSLPFSVEALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSSFSLPFPISSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS

Target ORF information:

RefSeq Version	NM_002449.4
Organism	Homo sapiens(human)
Definition	Homo sapiens msh homeobox 2 (MSX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002449.4

ORF Insert Sequence:

ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC 
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG 
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG 
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG 
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC 
CGATATTCGC CGCCGCCAAG ACATATGAGC CCTACCACCT GCACCCTGAG GAAACACAAG 
ACCAATCGGA AGCCGCGCAC GCCCTTTACC ACATCCCAGC TCCTCGCCCT GGAGCGCAAG 
TTCCGTCAGA AACAGTACCT CTCCATTGCA GAGCGTGCAG AGTTCTCCAG CTCTCTGAAC 
CTCACAGAGA CCCAGGTCAA AATCTGGTTC CAGAACCGAA GGGCCAAGGC GAAAAGACTG 
CAGGAGGCAG AACTGGAAAA GCTGAAAATG GCTGCAAAAC CTATGCTGCC CTCCAGCTTC 
AGTCTCCCTT TCCCCATCAG CTCGCCCCTG CAGGCAGCGT CCATATATGG AGCATCCTAC 
CCGTTCCATA GACCTGTGCT TCCCATCCCG CCTGTGGGAC TCTATGCCAC GCCAGTGGGA 
TATGGCATGT ACCACCTGTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSX2 ( NM_002449.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002440.2 Homo sapiens msh homeobox 2 (MSX2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21502
Clone ID Related Accession (Same CDS sequence)	NM_002449.4 , NM_002449.5
Accession Version	NM_002449.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	homeobox protein MSX-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL552909.3, AC117531.2, W38629.1 and D89377.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002449.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.79072.1, SRR1660805.143303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000239243.7/ ENSP00000239243.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC 
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG 
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG 
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG 
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC 
CGATATTCGC CGCCGCCAAG ACATATGAGC CCTACCACCT GCACCCTGAG GAAACACAAG 
ACCAATCGGA AGCCGCGCAC GCCCTTTACC ACATCCCAGC TCCTCGCCCT GGAGCGCAAG 
TTCCGTCAGA AACAGTACCT CTCCATTGCA GAGCGTGCAG AGTTCTCCAG CTCTCTGAAC 
CTCACAGAGA CCCAGGTCAA AATCTGGTTC CAGAACCGAA GGGCCAAGGC GAAAAGACTG 
CAGGAGGCAG AACTGGAAAA GCTGAAAATG GCTGCAAAAC CTATGCTGCC CTCCAGCTTC 
AGTCTCCCTT TCCCCATCAG CTCGCCCCTG CAGGCAGCGT CCATATATGG AGCATCCTAC 
CCGTTCCATA GACCTGTGCT TCCCATCCCG CCTGTGGGAC TCTATGCCAC GCCAGTGGGA 
TATGGCATGT ACCACCTGTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002440.2
CDS	79..882
Translation	MASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEERRVKVSSLPFSVEALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSSFSLPFPISSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS

Target ORF information:

RefSeq Version	NM_002449.5
Organism	Homo sapiens(human)
Definition	Homo sapiens msh homeobox 2 (MSX2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002449.5

ORF Insert Sequence:

ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC 
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG 
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG 
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG 
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC 
CGATATTCGC CGCCGCCAAG ACATATGAGC CCTACCACCT GCACCCTGAG GAAACACAAG 
ACCAATCGGA AGCCGCGCAC GCCCTTTACC ACATCCCAGC TCCTCGCCCT GGAGCGCAAG 
TTCCGTCAGA AACAGTACCT CTCCATTGCA GAGCGTGCAG AGTTCTCCAG CTCTCTGAAC 
CTCACAGAGA CCCAGGTCAA AATCTGGTTC CAGAACCGAA GGGCCAAGGC GAAAAGACTG 
CAGGAGGCAG AACTGGAAAA GCTGAAAATG GCTGCAAAAC CTATGCTGCC CTCCAGCTTC 
AGTCTCCCTT TCCCCATCAG CTCGCCCCTG CAGGCAGCGT CCATATATGG AGCATCCTAC 
CCGTTCCATA GACCTGTGCT TCCCATCCCG CCTGTGGGAC TCTATGCCAC GCCAGTGGGA 
TATGGCATGT ACCACCTGTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of TGF-β1 Signaling in Heart Valve Calcification Induced by Abnormal Mechanical Stimulation in a Tissue Engineering Model.
Current medical science38(5)765-775(2018 Oct)
Hu XJ,Wu WC,Dong NG,Shi JW,Liu JW,Chen S,Deng C,Shi F

[A novel chemo-resistant gene MSX2 discovered by establishment of two pancreatic cancer drug resistant cell lines JF305/CDDP and PANC-1/GEM].
Zhonghua zhong liu za zhi [Chinese journal of oncology]40(5)330-334(2018 May)
Yuan W,Sui CG,Ma X,Ma J

Regulation of proliferation in developing human tooth germs by MSX homeodomain proteins and cyclin-dependent kinase inhibitor p19
Organogenesis13(4)141-155(2017 10)
Kero D,Vukojevic K,Stazic P,Sundov D,Mardesic Brakus S,Saraga-Babic M

Prognostic Relevance and Function of MSX2 in Colorectal Cancer.
Journal of diabetes research20173827037(2017)
Liu J,An H,Yuan W,Feng Q,Chen L,Ma J

MSX2 Induces Trophoblast Invasion in Human Placenta.
PloS one11(4)e0153656(2016)
Liang H,Zhang Q,Lu J,Yang G,Tian N,Wang X,Tan Y,Tan D

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MSX2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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