MC4R cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MC4R
Entrez Gene ID	4160
Full Name	melanocortin 4 receptor
General protein information	Preferred Names melanocortin 4 receptor Names melanocortin receptor 4 MC4-R
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q21.32
Summary	The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010].
Disorder MIM:	155541
Disorder Html:	Obesity, autosomal dominant, 601665 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005912.3	NP_005903.2	melanocortin receptor 4
NM_005912.2	NP_005903.2	melanocortin receptor 4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MC4R	NP_776535.1
Mus musculus (house mouse)	Mc4r	NP_058673.2
Xenopus tropicalis (tropical clawed frog)	mc4r	XP_004915370.1
Homo sapiens (human)	MC4R	NP_005903.2
Canis lupus familiaris (dog)	MC4R	NP_001074193.1
Macaca mulatta (Rhesus monkey)	MC4R	XP_001088600.1
Pan troglodytes (chimpanzee)	MC4R	NP_001153207.1
Rattus norvegicus (Norway rat)	Mc4r	NP_037231.1
Gallus gallus (chicken)	MC4R	NP_001026685.1
Danio rerio (zebrafish)	mc4r	NP_775385.1

Gene Ontology
Bibliography

Related articles in PubMed

MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia.
Batarfi AA, Filimban N, Bajouh OS, Dallol A, Chaudhary AG, Bakhashab S
BMC medical genetics20(1)144(2019 08)

MC4R and HNF4α promoter methylation at birth contribute to triglyceride levels in childhood: A prospective cohort study.
Kwon EJ, Lee HA, You YA, Yoo JY, Park H, Park EA, Ha EH, Kim YJ
Medicine98(28)e16424(2019 Jul)

Genetic screening for MC4R gene identifies three novel mutations associated with severe familiar obesity in a cohort of Spanish individuals.
Gimeno-Ferrer F, Albuquerque D, García Banacloy A, Guzmán Luján C, Vidal Garcia C, Marcaida Benito G, Sánchez Juan C, Bruna Esteban M, Rodríguez-López R
Gene70474-79(2019 Jul)

Melanocortin-4 Receptor and Lipocalin 2 Gene Variants in Spanish Children with Abdominal Obesity: Effects on BMI-SDS After a Lifestyle Intervention.
Morell-Azanza L, Ojeda-Rodríguez A, Giuranna J, Azcona-SanJulián MC, Hebebrand J, Marti A, Hinney A
Nutrients11(5)(2019 Apr)

Combined effect of FTO and MC4R gene polymorphisms on obesity in children and adolescents in Northwest China: a case-control study.
Yang Y, Gao X, Tao X, Gao Q, Zhang Y, Yang J
Asia Pacific journal of clinical nutrition28(1)177-182(2019)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MC4R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MC4R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24975	NM_005912.3 Latest version!	Homo sapiens melanocortin 4 receptor (MC4R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu24975	NM_005912.2	Homo sapiens melanocortin 4 receptor (MC4R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MC4R ( NM_005912.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005903.2 Homo sapiens melanocortin 4 receptor (MC4R), mRNA.

Price & Availability↑

CloneID	OHu24975
Clone ID Related Accession (Same CDS sequence)	NM_005912.3 , NM_005912.2
Accession Version	NM_005912.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Homo sapiens(human)
Product	melanocortin receptor 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU310210.1, DA362673.1, BC101802.1 and AC091576.11. This sequence is a reference standard in the RefSeqGene project. On Jan 9, 2019 this sequence version replaced NM_005912.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR1803613.128716.1, SRR1660809.248284.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000299766.5/ ENSP00000299766.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGTGAACT CCACCCACCG TGGGATGCAC ACTTCTCTGC ACCTCTGGAA CCGCAGCAGT 
TACAGACTGC ACAGCAATGC CAGTGAGTCC CTTGGAAAAG GCTACTCTGA TGGAGGGTGC 
TACGAGCAAC TTTTTGTCTC TCCTGAGGTG TTTGTGACTC TGGGTGTCAT CAGCTTGTTG 
GAGAATATCT TAGTGATTGT GGCAATAGCC AAGAACAAGA ATCTGCATTC ACCCATGTAC 
TTTTTCATCT GCAGCTTGGC TGTGGCTGAT ATGCTGGTGA GCGTTTCAAA TGGATCAGAA 
ACCATTGTCA TCACCCTATT AAACAGTACA GATACGGATG CACAGAGTTT CACAGTGAAT 
ATTGATAATG TCATTGACTC GGTGATCTGT AGCTCCTTGC TTGCATCCAT TTGCAGCCTG 
CTTTCAATTG CAGTGGACAG GTACTTTACT ATCTTCTATG CTCTCCAGTA CCATAACATT 
ATGACAGTTA AGCGGGTTGG GATCATCATA AGTTGTATCT GGGCAGCTTG CACGGTTTCA 
GGCATTTTGT TCATCATTTA CTCAGATAGT AGTGCTGTCA TCATCTGCCT CATCACCATG 
TTCTTCACCA TGCTGGCTCT CATGGCTTCT CTCTATGTCC ACATGTTCCT GATGGCCAGG 
CTTCACATTA AGAGGATTGC TGTCCTCCCC GGCACTGGTG CCATCCGCCA AGGTGCCAAT 
ATGAAGGGAG CGATTACCTT GACCATCCTG ATTGGCGTCT TTGTTGTCTG CTGGGCCCCA 
TTCTTCCTCC ACTTAATATT CTACATCTCT TGTCCTCAGA ATCCATATTG TGTGTGCTTC 
ATGTCTCACT TTAACTTGTA TCTCATACTG ATCATGTGTA ATTCAATCAT CGATCCTCTG 
ATTTATGCAC TCCGGAGTCA AGAACTGAGG AAAACCTTCA AAGAGATCAT CTGTTGCTAT 
CCCCTGGGAG GCCTTTGTGA CTTGTCTAGC AGATATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005903.2
CDS	427..1425
Translation	MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY

Target ORF information:

RefSeq Version	NM_005912.3
Organism	Homo sapiens(human)
Definition	Homo sapiens melanocortin 4 receptor (MC4R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005912.3

ORF Insert Sequence:

ATGGTGAACT CCACCCACCG TGGGATGCAC ACTTCTCTGC ACCTCTGGAA CCGCAGCAGT 
TACAGACTGC ACAGCAATGC CAGTGAGTCC CTTGGAAAAG GCTACTCTGA TGGAGGGTGC 
TACGAGCAAC TTTTTGTCTC TCCTGAGGTG TTTGTGACTC TGGGTGTCAT CAGCTTGTTG 
GAGAATATCT TAGTGATTGT GGCAATAGCC AAGAACAAGA ATCTGCATTC ACCCATGTAC 
TTTTTCATCT GCAGCTTGGC TGTGGCTGAT ATGCTGGTGA GCGTTTCAAA TGGATCAGAA 
ACCATTGTCA TCACCCTATT AAACAGTACA GATACGGATG CACAGAGTTT CACAGTGAAT 
ATTGATAATG TCATTGACTC GGTGATCTGT AGCTCCTTGC TTGCATCCAT TTGCAGCCTG 
CTTTCAATTG CAGTGGACAG GTACTTTACT ATCTTCTATG CTCTCCAGTA CCATAACATT 
ATGACAGTTA AGCGGGTTGG GATCATCATA AGTTGTATCT GGGCAGCTTG CACGGTTTCA 
GGCATTTTGT TCATCATTTA CTCAGATAGT AGTGCTGTCA TCATCTGCCT CATCACCATG 
TTCTTCACCA TGCTGGCTCT CATGGCTTCT CTCTATGTCC ACATGTTCCT GATGGCCAGG 
CTTCACATTA AGAGGATTGC TGTCCTCCCC GGCACTGGTG CCATCCGCCA AGGTGCCAAT 
ATGAAGGGAG CGATTACCTT GACCATCCTG ATTGGCGTCT TTGTTGTCTG CTGGGCCCCA 
TTCTTCCTCC ACTTAATATT CTACATCTCT TGTCCTCAGA ATCCATATTG TGTGTGCTTC 
ATGTCTCACT TTAACTTGTA TCTCATACTG ATCATGTGTA ATTCAATCAT CGATCCTCTG 
ATTTATGCAC TCCGGAGTCA AGAACTGAGG AAAACCTTCA AAGAGATCAT CTGTTGCTAT 
CCCCTGGGAG GCCTTTGTGA CTTGTCTAGC AGATATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MC4R ( NM_005912.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005903.2 Homo sapiens melanocortin 4 receptor (MC4R), mRNA.

Price & Availability↑

CloneID	OHu24975
Clone ID Related Accession (Same CDS sequence)	NM_005912.3 , NM_005912.2
Accession Version	NM_005912.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1545408000000
Organism	Homo sapiens(human)
Product	melanocortin receptor 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA362673.1 and BC101802.1. This sequence is a reference standard in the RefSeqGene project. On Dec 16, 2006 this sequence version replaced NM_005912.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGTGAACT CCACCCACCG TGGGATGCAC ACTTCTCTGC ACCTCTGGAA CCGCAGCAGT 
TACAGACTGC ACAGCAATGC CAGTGAGTCC CTTGGAAAAG GCTACTCTGA TGGAGGGTGC 
TACGAGCAAC TTTTTGTCTC TCCTGAGGTG TTTGTGACTC TGGGTGTCAT CAGCTTGTTG 
GAGAATATCT TAGTGATTGT GGCAATAGCC AAGAACAAGA ATCTGCATTC ACCCATGTAC 
TTTTTCATCT GCAGCTTGGC TGTGGCTGAT ATGCTGGTGA GCGTTTCAAA TGGATCAGAA 
ACCATTGTCA TCACCCTATT AAACAGTACA GATACGGATG CACAGAGTTT CACAGTGAAT 
ATTGATAATG TCATTGACTC GGTGATCTGT AGCTCCTTGC TTGCATCCAT TTGCAGCCTG 
CTTTCAATTG CAGTGGACAG GTACTTTACT ATCTTCTATG CTCTCCAGTA CCATAACATT 
ATGACAGTTA AGCGGGTTGG GATCATCATA AGTTGTATCT GGGCAGCTTG CACGGTTTCA 
GGCATTTTGT TCATCATTTA CTCAGATAGT AGTGCTGTCA TCATCTGCCT CATCACCATG 
TTCTTCACCA TGCTGGCTCT CATGGCTTCT CTCTATGTCC ACATGTTCCT GATGGCCAGG 
CTTCACATTA AGAGGATTGC TGTCCTCCCC GGCACTGGTG CCATCCGCCA AGGTGCCAAT 
ATGAAGGGAG CGATTACCTT GACCATCCTG ATTGGCGTCT TTGTTGTCTG CTGGGCCCCA 
TTCTTCCTCC ACTTAATATT CTACATCTCT TGTCCTCAGA ATCCATATTG TGTGTGCTTC 
ATGTCTCACT TTAACTTGTA TCTCATACTG ATCATGTGTA ATTCAATCAT CGATCCTCTG 
ATTTATGCAC TCCGGAGTCA AGAACTGAGG AAAACCTTCA AAGAGATCAT CTGTTGCTAT 
CCCCTGGGAG GCCTTTGTGA CTTGTCTAGC AGATATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005903.2
CDS	420..1418
Translation	MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY

Target ORF information:

RefSeq Version	NM_005912.2
Organism	Homo sapiens(human)
Definition	Homo sapiens melanocortin 4 receptor (MC4R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005912.2

ORF Insert Sequence:

ATGGTGAACT CCACCCACCG TGGGATGCAC ACTTCTCTGC ACCTCTGGAA CCGCAGCAGT 
TACAGACTGC ACAGCAATGC CAGTGAGTCC CTTGGAAAAG GCTACTCTGA TGGAGGGTGC 
TACGAGCAAC TTTTTGTCTC TCCTGAGGTG TTTGTGACTC TGGGTGTCAT CAGCTTGTTG 
GAGAATATCT TAGTGATTGT GGCAATAGCC AAGAACAAGA ATCTGCATTC ACCCATGTAC 
TTTTTCATCT GCAGCTTGGC TGTGGCTGAT ATGCTGGTGA GCGTTTCAAA TGGATCAGAA 
ACCATTGTCA TCACCCTATT AAACAGTACA GATACGGATG CACAGAGTTT CACAGTGAAT 
ATTGATAATG TCATTGACTC GGTGATCTGT AGCTCCTTGC TTGCATCCAT TTGCAGCCTG 
CTTTCAATTG CAGTGGACAG GTACTTTACT ATCTTCTATG CTCTCCAGTA CCATAACATT 
ATGACAGTTA AGCGGGTTGG GATCATCATA AGTTGTATCT GGGCAGCTTG CACGGTTTCA 
GGCATTTTGT TCATCATTTA CTCAGATAGT AGTGCTGTCA TCATCTGCCT CATCACCATG 
TTCTTCACCA TGCTGGCTCT CATGGCTTCT CTCTATGTCC ACATGTTCCT GATGGCCAGG 
CTTCACATTA AGAGGATTGC TGTCCTCCCC GGCACTGGTG CCATCCGCCA AGGTGCCAAT 
ATGAAGGGAG CGATTACCTT GACCATCCTG ATTGGCGTCT TTGTTGTCTG CTGGGCCCCA 
TTCTTCCTCC ACTTAATATT CTACATCTCT TGTCCTCAGA ATCCATATTG TGTGTGCTTC 
ATGTCTCACT TTAACTTGTA TCTCATACTG ATCATGTGTA ATTCAATCAT CGATCCTCTG 
ATTTATGCAC TCCGGAGTCA AGAACTGAGG AAAACCTTCA AAGAGATCAT CTGTTGCTAT 
CCCCTGGGAG GCCTTTGTGA CTTGTCTAGC AGATATTAA