MC2R cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MC2R
Entrez Gene ID	4158
Full Name	melanocortin 2 receptor
Synonyms	ACTHR
General protein information	Preferred Names melanocortin 2 receptor Names adrenocorticotropic hormone receptor ACTH receptor MC2 receptor adrenocorticotropin receptor corticotropin receptor melanocortin 2 receptor (adrenocorticotropic hormone)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18p11.21
Summary	MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014].
Disorder MIM:	607397
Disorder Html:	Glucocorticoid deficiency, due to ACTH unresponsiveness, 202200 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017025781.1	XP_016881270.1	adrenocorticotropic hormone receptor isoform X1
NM_000529.2	NP_000520.1	adrenocorticotropic hormone receptor
NM_001291911.1	NP_001278840.1	adrenocorticotropic hormone receptor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MC2R	XP_003638804.1
Pan troglodytes (chimpanzee)	MC2R	XP_512192.1
Mus musculus (house mouse)	Mc2r	NP_001258645.1
Danio rerio (zebrafish)	mc2r	NP_851302.1
Macaca mulatta (Rhesus monkey)	MC2R	XP_001090666.1
Homo sapiens (human)	MC2R	NP_000520.1
Bos taurus (cattle)	MC2R	NP_776534.1
Rattus norvegicus (Norway rat)	Mc2r	NP_001093961.1
Gallus gallus (chicken)	MC2R	NP_001026686.1
Xenopus tropicalis (tropical clawed frog)	LOC100491330	XP_002936118.2

Gene Ontology
Bibliography

Related articles in PubMed

Amino acid residue L112 in the ACTH receptor plays a key role in ACTH or α-MSH selectivity.
Yang Y, Chen M, Ventro G, Harmon CM
Molecular and cellular endocrinology48211-17(2019 02)

Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8
Andersen M, Nagaev I, Meyer MK, Nagaeva O, Wikberg J, Mincheva-Nilsson L, Andersen GN
Scandinavian journal of immunology86(1)31-39(2017 Jul)

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandía J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morató X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pržulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I
Molecular systems biology13(3)918(2017 03)

Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.
Permuth JB, Pirie A, Ann Chen Y, Lin HY, Reid BM, Chen Z, Monteiro A, Dennis J, Mendoza-Fandino G, , , Anton-Culver H, Bandera EV, Bisogna M, Brinton L, Brooks-Wilson A, Carney ME, Chenevix-Trench G, Cook LS, Cramer DW, Cunningham JM, Cybulski C, D'Aloisio AA, Anne Doherty J, Earp M, Edwards RP, Fridley BL, Gayther SA, Gentry-Maharaj A, Goodman MT, Gronwald J, Hogdall E, Iversen ES, Jakubowska A, Jensen A, Karlan BY, Kelemen LE, Kjaer SK, Kraft P, Le ND, Levine DA, Lissowska J, Lubinski J, Matsuo K, Menon U, Modugno R, Moysich KB, Nakanishi T, Ness RB, Olson S, Orlow I, Pearce CL, Pejovic T, Poole EM, Ramus SJ, Anne Rossing M, Sandler DP, Shu XO, Song H, Taylor JA, Teo SH, Terry KL, Thompson PJ, Tworoger SS, Webb PM, Wentzensen N, Wilkens LR, Winham S, Woo YL, Wu AH, Yang H, Zheng W, Ziogas A, Phelan CM, Schildkraut JM, Berchuck A, Goode EL, Pharoah PD, Sellers TA,
Human molecular genetics25(16)3600-3612(2016 08)

Expression of melanocortin receptors in human endometrium.
Lantang AM, Innes BA, Gan EH, Pearce SH, Lash GE
Human reproduction (Oxford, England)30(10)2404-10(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MC2R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MC2R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21984	NM_001291911.1 Latest version!	Homo sapiens melanocortin 2 receptor (MC2R), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OHu21984	NM_000529.2 Latest version!	Homo sapiens melanocortin 2 receptor (MC2R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OHu21984	XM_017025781.1 Latest version!	Homo sapiens melanocortin 2 receptor (MC2R), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MC2R ( NM_000529.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000520.1 Homo sapiens melanocortin 2 receptor (MC2R), mRNA.

Price & Availability↑

CloneID	OHu21984
Clone ID Related Accession (Same CDS sequence)	XM_017025781.1 , NM_000529.2 , NM_001291911.1
Accession Version	NM_000529.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Homo sapiens(human)
Product	adrenocorticotropic hormone receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC094710.1 and AP001086.7. This sequence is a reference standard in the RefSeqGene project. On May 19, 2005 this sequence version replaced NM_000529.1. Transcript Variant: This variant (1) and variant 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094710.1, AK289381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327606.4/ ENSP00000333821.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCACA TTATCAACTC GTATGAAAAC ATCAACAACA CAGCAAGAAA TAATTCCGAC 
TGTCCTCGTG TGGTTTTGCC GGAGGAGATA TTTTTCACAA TTTCCATTGT TGGAGTTTTG 
GAGAATCTGA TCGTCCTGCT GGCTGTGTTC AAGAATAAGA ATCTCCAGGC ACCCATGTAC 
TTTTTCATCT GTAGCTTGGC CATATCTGAT ATGCTGGGCA GCCTATATAA GATCTTGGAA 
AATATCCTGA TCATATTGAG AAACATGGGC TATCTCAAGC CACGTGGCAG TTTTGAAACC 
ACAGCCGATG ACATCATCGA CTCCCTGTTT GTCCTCTCCC TGCTTGGCTC CATCTTCAGC 
CTGTCTGTGA TTGCTGCGGA CCGCTACATC ACCATCTTCC ACGCACTGCG GTACCACAGC 
ATCGTGACCA TGCGCCGCAC TGTGGTGGTG CTTACGGTCA TCTGGACGTT CTGCACGGGG 
ACTGGCATCA CCATGGTGAT CTTCTCCCAT CATGTGCCCA CAGTGATCAC CTTCACGTCG 
CTGTTCCCGC TGATGCTGGT CTTCATCCTG TGCCTCTATG TGCACATGTT CCTGCTGGCT 
CGATCCCACA CCAGGAAGAT CTCCACCCTC CCCAGAGCCA ACATGAAAGG GGCCATCACA 
CTGACCATCC TGCTCGGGGT CTTCATCTTC TGCTGGGCCC CCTTTGTGCT TCATGTCCTC 
TTGATGACAT TCTGCCCAAG TAACCCCTAC TGCGCCTGCT ACATGTCTCT CTTCCAGGTG 
AACGGCATGT TGATCATGTG CAATGCCGTC ATTGACCCCT TCATATATGC CTTCCGGAGC 
CCAGAGCTCA GGGACGCATT CAAAAAGATG ATCTTCTGCA GCAGGTACTG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000520.1
CDS	178..1071
Translation	MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW

Target ORF information:

RefSeq Version	NM_000529.2
Organism	Homo sapiens(human)
Definition	Homo sapiens melanocortin 2 receptor (MC2R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000529.2

ORF Insert Sequence:

ATGAAGCACA TTATCAACTC GTATGAAAAC ATCAACAACA CAGCAAGAAA TAATTCCGAC 
TGTCCTCGTG TGGTTTTGCC GGAGGAGATA TTTTTCACAA TTTCCATTGT TGGAGTTTTG 
GAGAATCTGA TCGTCCTGCT GGCTGTGTTC AAGAATAAGA ATCTCCAGGC ACCCATGTAC 
TTTTTCATCT GTAGCTTGGC CATATCTGAT ATGCTGGGCA GCCTATATAA GATCTTGGAA 
AATATCCTGA TCATATTGAG AAACATGGGC TATCTCAAGC CACGTGGCAG TTTTGAAACC 
ACAGCCGATG ACATCATCGA CTCCCTGTTT GTCCTCTCCC TGCTTGGCTC CATCTTCAGC 
CTGTCTGTGA TTGCTGCGGA CCGCTACATC ACCATCTTCC ACGCACTGCG GTACCACAGC 
ATCGTGACCA TGCGCCGCAC TGTGGTGGTG CTTACGGTCA TCTGGACGTT CTGCACGGGG 
ACTGGCATCA CCATGGTGAT CTTCTCCCAT CATGTGCCCA CAGTGATCAC CTTCACGTCG 
CTGTTCCCGC TGATGCTGGT CTTCATCCTG TGCCTCTATG TGCACATGTT CCTGCTGGCT 
CGATCCCACA CCAGGAAGAT CTCCACCCTC CCCAGAGCCA ACATGAAAGG GGCCATCACA 
CTGACCATCC TGCTCGGGGT CTTCATCTTC TGCTGGGCCC CCTTTGTGCT TCATGTCCTC 
TTGATGACAT TCTGCCCAAG TAACCCCTAC TGCGCCTGCT ACATGTCTCT CTTCCAGGTG 
AACGGCATGT TGATCATGTG CAATGCCGTC ATTGACCCCT TCATATATGC CTTCCGGAGC 
CCAGAGCTCA GGGACGCATT CAAAAAGATG ATCTTCTGCA GCAGGTACTG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MC2R ( NM_001291911.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278840.1 Homo sapiens melanocortin 2 receptor (MC2R), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21984
Clone ID Related Accession (Same CDS sequence)	XM_017025781.1 , NM_000529.2 , NM_001291911.1
Accession Version	NM_001291911.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574006400000
Organism	Homo sapiens(human)
Product	adrenocorticotropic hormone receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP196054.1 and AP001086.7. Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP196054.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465401 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCACA TTATCAACTC GTATGAAAAC ATCAACAACA CAGCAAGAAA TAATTCCGAC 
TGTCCTCGTG TGGTTTTGCC GGAGGAGATA TTTTTCACAA TTTCCATTGT TGGAGTTTTG 
GAGAATCTGA TCGTCCTGCT GGCTGTGTTC AAGAATAAGA ATCTCCAGGC ACCCATGTAC 
TTTTTCATCT GTAGCTTGGC CATATCTGAT ATGCTGGGCA GCCTATATAA GATCTTGGAA 
AATATCCTGA TCATATTGAG AAACATGGGC TATCTCAAGC CACGTGGCAG TTTTGAAACC 
ACAGCCGATG ACATCATCGA CTCCCTGTTT GTCCTCTCCC TGCTTGGCTC CATCTTCAGC 
CTGTCTGTGA TTGCTGCGGA CCGCTACATC ACCATCTTCC ACGCACTGCG GTACCACAGC 
ATCGTGACCA TGCGCCGCAC TGTGGTGGTG CTTACGGTCA TCTGGACGTT CTGCACGGGG 
ACTGGCATCA CCATGGTGAT CTTCTCCCAT CATGTGCCCA CAGTGATCAC CTTCACGTCG 
CTGTTCCCGC TGATGCTGGT CTTCATCCTG TGCCTCTATG TGCACATGTT CCTGCTGGCT 
CGATCCCACA CCAGGAAGAT CTCCACCCTC CCCAGAGCCA ACATGAAAGG GGCCATCACA 
CTGACCATCC TGCTCGGGGT CTTCATCTTC TGCTGGGCCC CCTTTGTGCT TCATGTCCTC 
TTGATGACAT TCTGCCCAAG TAACCCCTAC TGCGCCTGCT ACATGTCTCT CTTCCAGGTG 
AACGGCATGT TGATCATGTG CAATGCCGTC ATTGACCCCT TCATATATGC CTTCCGGAGC 
CCAGAGCTCA GGGACGCATT CAAAAAGATG ATCTTCTGCA GCAGGTACTG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278840.1
CDS	207..1100
Translation	MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW

Target ORF information:

RefSeq Version	NM_001291911.1
Organism	Homo sapiens(human)
Definition	Homo sapiens melanocortin 2 receptor (MC2R), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291911.1

ORF Insert Sequence:

ATGAAGCACA TTATCAACTC GTATGAAAAC ATCAACAACA CAGCAAGAAA TAATTCCGAC 
TGTCCTCGTG TGGTTTTGCC GGAGGAGATA TTTTTCACAA TTTCCATTGT TGGAGTTTTG 
GAGAATCTGA TCGTCCTGCT GGCTGTGTTC AAGAATAAGA ATCTCCAGGC ACCCATGTAC 
TTTTTCATCT GTAGCTTGGC CATATCTGAT ATGCTGGGCA GCCTATATAA GATCTTGGAA 
AATATCCTGA TCATATTGAG AAACATGGGC TATCTCAAGC CACGTGGCAG TTTTGAAACC 
ACAGCCGATG ACATCATCGA CTCCCTGTTT GTCCTCTCCC TGCTTGGCTC CATCTTCAGC 
CTGTCTGTGA TTGCTGCGGA CCGCTACATC ACCATCTTCC ACGCACTGCG GTACCACAGC 
ATCGTGACCA TGCGCCGCAC TGTGGTGGTG CTTACGGTCA TCTGGACGTT CTGCACGGGG 
ACTGGCATCA CCATGGTGAT CTTCTCCCAT CATGTGCCCA CAGTGATCAC CTTCACGTCG 
CTGTTCCCGC TGATGCTGGT CTTCATCCTG TGCCTCTATG TGCACATGTT CCTGCTGGCT 
CGATCCCACA CCAGGAAGAT CTCCACCCTC CCCAGAGCCA ACATGAAAGG GGCCATCACA 
CTGACCATCC TGCTCGGGGT CTTCATCTTC TGCTGGGCCC CCTTTGTGCT TCATGTCCTC 
TTGATGACAT TCTGCCCAAG TAACCCCTAC TGCGCCTGCT ACATGTCTCT CTTCCAGGTG 
AACGGCATGT TGATCATGTG CAATGCCGTC ATTGACCCCT TCATATATGC CTTCCGGAGC 
CCAGAGCTCA GGGACGCATT CAAAAAGATG ATCTTCTGCA GCAGGTACTG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MC2R ( XM_017025781.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881270.1 Homo sapiens melanocortin 2 receptor (MC2R), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu21984
Clone ID Related Accession (Same CDS sequence)	XM_017025781.1 , NM_000529.2 , NM_001291911.1
Accession Version	XM_017025781.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	adrenocorticotropic hormone receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCACA TTATCAACTC GTATGAAAAC ATCAACAACA CAGCAAGAAA TAATTCCGAC 
TGTCCTCGTG TGGTTTTGCC GGAGGAGATA TTTTTCACAA TTTCCATTGT TGGAGTTTTG 
GAGAATCTGA TCGTCCTGCT GGCTGTGTTC AAGAATAAGA ATCTCCAGGC ACCCATGTAC 
TTTTTCATCT GTAGCTTGGC CATATCTGAT ATGCTGGGCA GCCTATATAA GATCTTGGAA 
AATATCCTGA TCATATTGAG AAACATGGGC TATCTCAAGC CACGTGGCAG TTTTGAAACC 
ACAGCCGATG ACATCATCGA CTCCCTGTTT GTCCTCTCCC TGCTTGGCTC CATCTTCAGC 
CTGTCTGTGA TTGCTGCGGA CCGCTACATC ACCATCTTCC ACGCACTGCG GTACCACAGC 
ATCGTGACCA TGCGCCGCAC TGTGGTGGTG CTTACGGTCA TCTGGACGTT CTGCACGGGG 
ACTGGCATCA CCATGGTGAT CTTCTCCCAT CATGTGCCCA CAGTGATCAC CTTCACGTCG 
CTGTTCCCGC TGATGCTGGT CTTCATCCTG TGCCTCTATG TGCACATGTT CCTGCTGGCT 
CGATCCCACA CCAGGAAGAT CTCCACCCTC CCCAGAGCCA ACATGAAAGG GGCCATCACA 
CTGACCATCC TGCTCGGGGT CTTCATCTTC TGCTGGGCCC CCTTTGTGCT TCATGTCCTC 
TTGATGACAT TCTGCCCAAG TAACCCCTAC TGCGCCTGCT ACATGTCTCT CTTCCAGGTG 
AACGGCATGT TGATCATGTG CAATGCCGTC ATTGACCCCT TCATATATGC CTTCCGGAGC 
CCAGAGCTCA GGGACGCATT CAAAAAGATG ATCTTCTGCA GCAGGTACTG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881270.1
CDS	800..1693
Translation	MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW

Target ORF information:

RefSeq Version	XM_017025781.1
Organism	Homo sapiens(human)
Definition	Homo sapiens melanocortin 2 receptor (MC2R), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017025781.1

ORF Insert Sequence:

ATGAAGCACA TTATCAACTC GTATGAAAAC ATCAACAACA CAGCAAGAAA TAATTCCGAC 
TGTCCTCGTG TGGTTTTGCC GGAGGAGATA TTTTTCACAA TTTCCATTGT TGGAGTTTTG 
GAGAATCTGA TCGTCCTGCT GGCTGTGTTC AAGAATAAGA ATCTCCAGGC ACCCATGTAC 
TTTTTCATCT GTAGCTTGGC CATATCTGAT ATGCTGGGCA GCCTATATAA GATCTTGGAA 
AATATCCTGA TCATATTGAG AAACATGGGC TATCTCAAGC CACGTGGCAG TTTTGAAACC 
ACAGCCGATG ACATCATCGA CTCCCTGTTT GTCCTCTCCC TGCTTGGCTC CATCTTCAGC 
CTGTCTGTGA TTGCTGCGGA CCGCTACATC ACCATCTTCC ACGCACTGCG GTACCACAGC 
ATCGTGACCA TGCGCCGCAC TGTGGTGGTG CTTACGGTCA TCTGGACGTT CTGCACGGGG 
ACTGGCATCA CCATGGTGAT CTTCTCCCAT CATGTGCCCA CAGTGATCAC CTTCACGTCG 
CTGTTCCCGC TGATGCTGGT CTTCATCCTG TGCCTCTATG TGCACATGTT CCTGCTGGCT 
CGATCCCACA CCAGGAAGAT CTCCACCCTC CCCAGAGCCA ACATGAAAGG GGCCATCACA 
CTGACCATCC TGCTCGGGGT CTTCATCTTC TGCTGGGCCC CCTTTGTGCT TCATGTCCTC 
TTGATGACAT TCTGCCCAAG TAACCCCTAC TGCGCCTGCT ACATGTCTCT CTTCCAGGTG 
AACGGCATGT TGATCATGTG CAATGCCGTC ATTGACCCCT TCATATATGC CTTCCGGAGC 
CCAGAGCTCA GGGACGCATT CAAAAAGATG ATCTTCTGCA GCAGGTACTG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Amino acid residue L112 in the ACTH receptor plays a key role in ACTH or α-MSH selectivity.
Molecular and cellular endocrinology48211-17(2019 02)
Yang Y,Chen M,Ventro G,Harmon CM

Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8
Scandinavian journal of immunology86(1)31-39(2017 Jul)
Andersen M,Nagaev I,Meyer MK,Nagaeva O,Wikberg J,Mincheva-Nilsson L,Andersen GN

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
Molecular systems biology13(3)918(2017 03)
Sokolina K,Kittanakom S,Snider J,Kotlyar M,Maurice P,Gandía J,Benleulmi-Chaachoua A,Tadagaki K,Oishi A,Wong V,Malty RH,Deineko V,Aoki H,Amin S,Yao Z,Morató X,Otasek D,Kobayashi H,Menendez J,Auerbach D,Angers S,Pržulj N,Bouvier M,Babu M,Ciruela F,Jockers R,Jurisica I,Stagljar I

Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.
Human molecular genetics25(16)3600-3612(2016 08)
Permuth JB,Pirie A,Ann Chen Y,Lin HY,Reid BM,Chen Z,Monteiro A,Dennis J,Mendoza-Fandino G,,,Anton-Culver H,Bandera EV,Bisogna M,Brinton L,Brooks-Wilson A,Carney ME,Chenevix-Trench G,Cook LS,Cramer DW,Cunningham JM,Cybulski C,D'Aloisio AA,Anne Doherty J,Earp M,Edwards RP,Fridley BL,Gayther SA,Gentry-Maharaj A,Goodman MT,Gronwald J,Hogdall E,Iversen ES,Jakubowska A,Jensen A,Karlan BY,Kelemen LE,Kjaer SK,Kraft P,Le ND,Levine DA,Lissowska J,Lubinski J,Matsuo K,Menon U,Modugno R,Moysich KB,Nakanishi T,Ness RB,Olson S,Orlow I,Pearce CL,Pejovic T,Poole EM,Ramus SJ,Anne Rossing M,Sandler DP,Shu XO,Song H,Taylor JA,Teo SH,Terry KL,Thompson PJ,Tworoger SS,Webb PM,Wentzensen N,Wilkens LR,Winham S,Woo YL,Wu AH,Yang H,Zheng W,Ziogas A,Phelan CM,Schildkraut JM,Berchuck A,Goode EL,Pharoah PD,Sellers TA,

Expression of melanocortin receptors in human endometrium.
Human reproduction (Oxford, England)30(10)2404-10(2015 Oct)
Lantang AM,Innes BA,Gan EH,Pearce SH,Lash GE

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MC2R cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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