LOX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LOX
Entrez Gene ID	4015
Full Name	lysyl oxidase
Synonyms	AAT10
General protein information	Preferred Names lysyl oxidase Names protein-lysine 6-oxidase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q23.1
Summary	This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016].
Disorder MIM:	153455
Disorder Html:	Aortic aneurysm, familial thoracic 10, 617168 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002317.6	NP_002308.2	protein-lysine 6-oxidase isoform 1 preproprotein
NM_002317.5	NP_002308.2	protein-lysine 6-oxidase isoform 1 preproprotein
NM_001178102.2	NP_001171573.1	protein-lysine 6-oxidase isoform 2
NM_002317.7	NP_002308.2	protein-lysine 6-oxidase isoform 1 preproprotein
NM_001317073.1	NP_001304002.1	protein-lysine 6-oxidase isoform 3

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	LOX	XP_001089079.1
Gallus gallus (chicken)	LOX	NP_990812.1
Xenopus tropicalis (tropical clawed frog)	lox	NP_001072611.1
Homo sapiens (human)	LOX	NP_002308.2
Pan troglodytes (chimpanzee)	LOX	XP_001153015.1
Rattus norvegicus (Norway rat)	Lox	NP_058757.1
Danio rerio (zebrafish)	lox	NP_996972.1
Bos taurus (cattle)	LOX	NP_776357.2
Canis lupus familiaris (dog)	LOX	XP_005626496.1
Mus musculus (house mouse)	Lox	NP_001273111.1

Gene Ontology
Bibliography

Related articles in PubMed

Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer.
Kalikawe R, Baba Y, Nomoto D, Okadome K, Miyake K, Eto K, Hiyoshi Y, Nagai Y, Iwatsuki M, Ishimoto T, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H
Cancer science110(12)3727-3737(2019 Dec)

Forkhead box C1 promotes metastasis and invasion of non-small cell lung cancer by binding directly to the lysyl oxidase promoter.
Gong R, Lin W, Gao A, Liu Y, Li J, Sun M, Chen X, Han S, Men C, Sun Y, Liu J
Cancer science110(12)3663-3676(2019 Dec)

Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.
Rosell-García T, Paradela A, Bravo G, Dupont L, Bekhouche M, Colige A, Rodriguez-Pascual F
The Journal of biological chemistry294(29)11087-11100(2019 Jul)

Lysyl oxidase and hypoxia-inducible factor 1α: biomarkers of gastric cancer.
Han YL, Chen L, Qin R, Wang GQ, Lin XH, Dai GH
World journal of gastroenterology25(15)1828-1839(2019 Apr)

A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans.
Hong EP, Jeon JP, Kim SE, Yang JS, Choi HJ, Kang SH, Cho YJ
Yonsei medical journal58(5)1006-1011(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following LOX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LOX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu102002	NM_001317073.1 Latest version!	Homo sapiens lysyl oxidase (LOX), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu20854	NM_001178102.2 Latest version!	Homo sapiens lysyl oxidase (LOX), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu21781	NM_002317.7 Latest version!	Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu21781	NM_002317.5	Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
OHu21781	NM_002317.6	Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LOX ( NM_001317073.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304002.1 Homo sapiens lysyl oxidase (LOX), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu102002
Clone ID Related Accession (Same CDS sequence)	NM_001317073.1
Accession Version	NM_001317073.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577462400000
Organism	Homo sapiens(human)
Product	protein-lysine 6-oxidase isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK307732.1, AC010255.9 and AI351010.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) is shorter at the N-terminus and lacks a predicted signal peptide compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK307732.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2145313, SAMEA2154125 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAGT TTAGCCACTA TGACCTGCTT GATGCCAACA CCCAGAGGAG AGTGGCTGAA 
GGCCACAAAG CAAGTTTCTG TCTTGAAGAC ACATCCTGTG ACTATGGCTA CCACAGGCGA 
TTTGCATGTA CTGCACACAC ACAGGGATTG AGTCCTGGCT GTTATGATAC CTATGGTGCA 
GACATAGACT GCCAGTGGAT TGATATTACA GATGTAAAAC CTGGAAACTA TATCCTAAAG 
GTCAGTGTAA ACCCCAGCTA CCTGGTTCCT GAATCTGACT ATACCAACAA TGTTGTGCGC 
TGTGACATTC GCTACACAGG ACATCATGCG TATGCCTCAG GCTGCACAAT TTCACCGTAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304002.1
CDS	235..597
Translation	MDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Target ORF information:

RefSeq Version	NM_001317073.1
Organism	Homo sapiens(human)
Definition	Homo sapiens lysyl oxidase (LOX), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317073.1

ORF Insert Sequence:

ATGGATGAGT TTAGCCACTA TGACCTGCTT GATGCCAACA CCCAGAGGAG AGTGGCTGAA 
GGCCACAAAG CAAGTTTCTG TCTTGAAGAC ACATCCTGTG ACTATGGCTA CCACAGGCGA 
TTTGCATGTA CTGCACACAC ACAGGGATTG AGTCCTGGCT GTTATGATAC CTATGGTGCA 
GACATAGACT GCCAGTGGAT TGATATTACA GATGTAAAAC CTGGAAACTA TATCCTAAAG 
GTCAGTGTAA ACCCCAGCTA CCTGGTTCCT GAATCTGACT ATACCAACAA TGTTGTGCGC 
TGTGACATTC GCTACACAGG ACATCATGCG TATGCCTCAG GCTGCACAAT TTCACCGTAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LOX ( NM_001178102.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001171573.1 Homo sapiens lysyl oxidase (LOX), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20854
Clone ID Related Accession (Same CDS sequence)	NM_001178102.2
Accession Version	NM_001178102.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577462400000
Organism	Homo sapiens(human)
Product	protein-lysine 6-oxidase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA720490.1, AC010255.9, CN265862.1, AK307732.1 and AI351010.1. On Nov 13, 2015 this sequence version replaced NM_001178102.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) is shorter at the N-terminus and lacks a predicted signal peptide compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.229647.1, SRR1803613.157434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCCATGT ACAACCTGAG ATGCGCGGCG GAGGAAAACT GTCTGGCCAG TACAGCATAC 
AGGGCAGATG TCAGAGATTA TGATCACAGG GTGCTGCTCA GATTTCCCCA AAGAGTGAAA 
AACCAAGGGA CATCAGATTT CTTACCCAGC CGACCAAGAT ATTCCTGGGA ATGGCACAGT 
TGTCATCAAC ATTACCACAG TATGGATGAG TTTAGCCACT ATGACCTGCT TGATGCCAAC 
ACCCAGAGGA GAGTGGCTGA AGGCCACAAA GCAAGTTTCT GTCTTGAAGA CACATCCTGT 
GACTATGGCT ACCACAGGCG ATTTGCATGT ACTGCACACA CACAGGGATT GAGTCCTGGC 
TGTTATGATA CCTATGGTGC AGACATAGAC TGCCAGTGGA TTGATATTAC AGATGTAAAA 
CCTGGAAACT ATATCCTAAA GGTCAGTGTA AACCCCAGCT ACCTGGTTCC TGAATCTGAC 
TATACCAACA ATGTTGTGCG CTGTGACATT CGCTACACAG GACATCATGC GTATGCCTCA 
GGCTGCACAA TTTCACCGTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171573.1
CDS	282..845
Translation	MSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Target ORF information:

RefSeq Version	NM_001178102.2
Organism	Homo sapiens(human)
Definition	Homo sapiens lysyl oxidase (LOX), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001178102.2

ORF Insert Sequence:

ATGTCCATGT ACAACCTGAG ATGCGCGGCG GAGGAAAACT GTCTGGCCAG TACAGCATAC 
AGGGCAGATG TCAGAGATTA TGATCACAGG GTGCTGCTCA GATTTCCCCA AAGAGTGAAA 
AACCAAGGGA CATCAGATTT CTTACCCAGC CGACCAAGAT ATTCCTGGGA ATGGCACAGT 
TGTCATCAAC ATTACCACAG TATGGATGAG TTTAGCCACT ATGACCTGCT TGATGCCAAC 
ACCCAGAGGA GAGTGGCTGA AGGCCACAAA GCAAGTTTCT GTCTTGAAGA CACATCCTGT 
GACTATGGCT ACCACAGGCG ATTTGCATGT ACTGCACACA CACAGGGATT GAGTCCTGGC 
TGTTATGATA CCTATGGTGC AGACATAGAC TGCCAGTGGA TTGATATTAC AGATGTAAAA 
CCTGGAAACT ATATCCTAAA GGTCAGTGTA AACCCCAGCT ACCTGGTTCC TGAATCTGAC 
TATACCAACA ATGTTGTGCG CTGTGACATT CGCTACACAG GACATCATGC GTATGCCTCA 
GGCTGCACAA TTTCACCGTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LOX ( NM_002317.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_002308.2 Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21781
Clone ID Related Accession (Same CDS sequence)	NM_002317.6 , NM_002317.5 , NM_002317.7
Accession Version	NM_002317.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514649600000
Organism	Homo sapiens(human)
Product	protein-lysine 6-oxidase isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC299494.1, BC089436.1, AK307732.1, AC010255.9 and AI351010.1. This sequence is a reference standard in the RefSeqGene project. On Nov 13, 2015 this sequence version replaced NM_002317.5. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.180662.1, SRR1660809.144734.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCGCTTCG CCTGGACCGT GCTCCTGCTC GGGCCTTTGC AGCTCTGCGC GCTAGTGCAC 
TGCGCCCCTC CCGCCGCCGG CCAACAGCAG CCCCCGCGCG AGCCGCCGGC GGCTCCGGGC 
GCCTGGCGCC AGCAGATCCA ATGGGAGAAC AACGGGCAGG TGTTCAGCTT GCTGAGCCTG 
GGCTCACAGT ACCAGCCTCA GCGCCGCCGG GACCCGGGCG CCGCCGTCCC TGGTGCAGCC 
AACGCCTCCG CCCAGCAGCC CCGCACTCCG ATCCTGCTGA TCCGCGACAA CCGCACCGCC 
GCGGCGCGAA CGCGGACGGC CGGCTCATCT GGAGTCACCG CTGGCCGCCC CAGGCCCACC 
GCCCGTCACT GGTTCCAAGC TGGCTACTCG ACATCTAGAG CCCGCGAAGC TGGCGCCTCG 
CGCGCGGAGA ACCAGACAGC GCCGGGAGAA GTTCCTGCGC TCAGTAACCT GCGGCCGCCC 
AGCCGCGTGG ACGGCATGGT GGGCGACGAC CCTTACAACC CCTACAAGTA CTCTGACGAC 
AACCCTTATT ACAACTACTA CGATACTTAT GAAAGGCCCA GACCTGGGGG CAGGTACCGG 
CCCGGATACG GCACTGGCTA CTTCCAGTAC GGTCTCCCAG ACCTGGTGGC CGACCCCTAC 
TACATCCAGG CGTCCACGTA CGTGCAGAAG ATGTCCATGT ACAACCTGAG ATGCGCGGCG 
GAGGAAAACT GTCTGGCCAG TACAGCATAC AGGGCAGATG TCAGAGATTA TGATCACAGG 
GTGCTGCTCA GATTTCCCCA AAGAGTGAAA AACCAAGGGA CATCAGATTT CTTACCCAGC 
CGACCAAGAT ATTCCTGGGA ATGGCACAGT TGTCATCAAC ATTACCACAG TATGGATGAG 
TTTAGCCACT ATGACCTGCT TGATGCCAAC ACCCAGAGGA GAGTGGCTGA AGGCCACAAA 
GCAAGTTTCT GTCTTGAAGA CACATCCTGT GACTATGGCT ACCACAGGCG ATTTGCATGT 
ACTGCACACA CACAGGGATT GAGTCCTGGC TGTTATGATA CCTATGGTGC AGACATAGAC 
TGCCAGTGGA TTGATATTAC AGATGTAAAA CCTGGAAACT ATATCCTAAA GGTCAGTGTA 
AACCCCAGCT ACCTGGTTCC TGAATCTGAC TATACCAACA ATGTTGTGCG CTGTGACATT 
CGCTACACAG GACATCATGC GTATGCCTCA GGCTGCACAA TTTCACCGTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002308.2
CDS	517..1770
Translation	MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Target ORF information:

RefSeq Version	NM_002317.6
Organism	Homo sapiens(human)
Definition	Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002317.6

ORF Insert Sequence:

ATGCGCTTCG CCTGGACCGT GCTCCTGCTC GGGCCTTTGC AGCTCTGCGC GCTAGTGCAC 
TGCGCCCCTC CCGCCGCCGG CCAACAGCAG CCCCCGCGCG AGCCGCCGGC GGCTCCGGGC 
GCCTGGCGCC AGCAGATCCA ATGGGAGAAC AACGGGCAGG TGTTCAGCTT GCTGAGCCTG 
GGCTCACAGT ACCAGCCTCA GCGCCGCCGG GACCCGGGCG CCGCCGTCCC TGGTGCAGCC 
AACGCCTCCG CCCAGCAGCC CCGCACTCCG ATCCTGCTGA TCCGCGACAA CCGCACCGCC 
GCGGCGCGAA CGCGGACGGC CGGCTCATCT GGAGTCACCG CTGGCCGCCC CAGGCCCACC 
GCCCGTCACT GGTTCCAAGC TGGCTACTCG ACATCTAGAG CCCGCGAAGC TGGCGCCTCG 
CGCGCGGAGA ACCAGACAGC GCCGGGAGAA GTTCCTGCGC TCAGTAACCT GCGGCCGCCC 
AGCCGCGTGG ACGGCATGGT GGGCGACGAC CCTTACAACC CCTACAAGTA CTCTGACGAC 
AACCCTTATT ACAACTACTA CGATACTTAT GAAAGGCCCA GACCTGGGGG CAGGTACCGG 
CCCGGATACG GCACTGGCTA CTTCCAGTAC GGTCTCCCAG ACCTGGTGGC CGACCCCTAC 
TACATCCAGG CGTCCACGTA CGTGCAGAAG ATGTCCATGT ACAACCTGAG ATGCGCGGCG 
GAGGAAAACT GTCTGGCCAG TACAGCATAC AGGGCAGATG TCAGAGATTA TGATCACAGG 
GTGCTGCTCA GATTTCCCCA AAGAGTGAAA AACCAAGGGA CATCAGATTT CTTACCCAGC 
CGACCAAGAT ATTCCTGGGA ATGGCACAGT TGTCATCAAC ATTACCACAG TATGGATGAG 
TTTAGCCACT ATGACCTGCT TGATGCCAAC ACCCAGAGGA GAGTGGCTGA AGGCCACAAA 
GCAAGTTTCT GTCTTGAAGA CACATCCTGT GACTATGGCT ACCACAGGCG ATTTGCATGT 
ACTGCACACA CACAGGGATT GAGTCCTGGC TGTTATGATA CCTATGGTGC AGACATAGAC 
TGCCAGTGGA TTGATATTAC AGATGTAAAA CCTGGAAACT ATATCCTAAA GGTCAGTGTA 
AACCCCAGCT ACCTGGTTCC TGAATCTGAC TATACCAACA ATGTTGTGCG CTGTGACATT 
CGCTACACAG GACATCATGC GTATGCCTCA GGCTGCACAA TTTCACCGTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LOX ( NM_002317.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002308.2 Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21781
Clone ID Related Accession (Same CDS sequence)	NM_002317.6 , NM_002317.5 , NM_002317.7
Accession Version	NM_002317.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426262400000
Organism	Homo sapiens(Human)
Product	protein-lysine 6-oxidase isoform 1 preproprotein
Comment

ATGCGCTTCG CCTGGACCGT GCTCCTGCTC GGGCCTTTGC AGCTCTGCGC GCTAGTGCAC 
TGCGCCCCTC CCGCCGCCGG CCAACAGCAG CCCCCGCGCG AGCCGCCGGC GGCTCCGGGC 
GCCTGGCGCC AGCAGATCCA ATGGGAGAAC AACGGGCAGG TGTTCAGCTT GCTGAGCCTG 
GGCTCACAGT ACCAGCCTCA GCGCCGCCGG GACCCGGGCG CCGCCGTCCC TGGTGCAGCC 
AACGCCTCCG CCCAGCAGCC CCGCACTCCG ATCCTGCTGA TCCGCGACAA CCGCACCGCC 
GCGGCGCGAA CGCGGACGGC CGGCTCATCT GGAGTCACCG CTGGCCGCCC CAGGCCCACC 
GCCCGTCACT GGTTCCAAGC TGGCTACTCG ACATCTAGAG CCCGCGAAGC TGGCGCCTCG 
CGCGCGGAGA ACCAGACAGC GCCGGGAGAA GTTCCTGCGC TCAGTAACCT GCGGCCGCCC 
AGCCGCGTGG ACGGCATGGT GGGCGACGAC CCTTACAACC CCTACAAGTA CTCTGACGAC 
AACCCTTATT ACAACTACTA CGATACTTAT GAAAGGCCCA GACCTGGGGG CAGGTACCGG 
CCCGGATACG GCACTGGCTA CTTCCAGTAC GGTCTCCCAG ACCTGGTGGC CGACCCCTAC 
TACATCCAGG CGTCCACGTA CGTGCAGAAG ATGTCCATGT ACAACCTGAG ATGCGCGGCG 
GAGGAAAACT GTCTGGCCAG TACAGCATAC AGGGCAGATG TCAGAGATTA TGATCACAGG 
GTGCTGCTCA GATTTCCCCA AAGAGTGAAA AACCAAGGGA CATCAGATTT CTTACCCAGC 
CGACCAAGAT ATTCCTGGGA ATGGCACAGT TGTCATCAAC ATTACCACAG TATGGATGAG 
TTTAGCCACT ATGACCTGCT TGATGCCAAC ACCCAGAGGA GAGTGGCTGA AGGCCACAAA 
GCAAGTTTCT GTCTTGAAGA CACATCCTGT GACTATGGCT ACCACAGGCG ATTTGCATGT 
ACTGCACACA CACAGGGATT GAGTCCTGGC TGTTATGATA CCTATGGTGC AGACATAGAC 
TGCCAGTGGA TTGATATTAC AGATGTAAAA CCTGGAAACT ATATCCTAAA GGTCAGTGTA 
AACCCCAGCT ACCTGGTTCC TGAATCTGAC TATACCAACA ATGTTGTGCG CTGTGACATT 
CGCTACACAG GACATCATGC GTATGCCTCA GGCTGCACAA TTTCACCGTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_002308.2

Translation

MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Target ORF information:

RefSeq Version	NM_002317.5
Organism	Homo sapiens(Human)
Definition	Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002317.5

ORF Insert Sequence:

ATGCGCTTCG CCTGGACCGT GCTCCTGCTC GGGCCTTTGC AGCTCTGCGC GCTAGTGCAC 
TGCGCCCCTC CCGCCGCCGG CCAACAGCAG CCCCCGCGCG AGCCGCCGGC GGCTCCGGGC 
GCCTGGCGCC AGCAGATCCA ATGGGAGAAC AACGGGCAGG TGTTCAGCTT GCTGAGCCTG 
GGCTCACAGT ACCAGCCTCA GCGCCGCCGG GACCCGGGCG CCGCCGTCCC TGGTGCAGCC 
AACGCCTCCG CCCAGCAGCC CCGCACTCCG ATCCTGCTGA TCCGCGACAA CCGCACCGCC 
GCGGCGCGAA CGCGGACGGC CGGCTCATCT GGAGTCACCG CTGGCCGCCC CAGGCCCACC 
GCCCGTCACT GGTTCCAAGC TGGCTACTCG ACATCTAGAG CCCGCGAAGC TGGCGCCTCG 
CGCGCGGAGA ACCAGACAGC GCCGGGAGAA GTTCCTGCGC TCAGTAACCT GCGGCCGCCC 
AGCCGCGTGG ACGGCATGGT GGGCGACGAC CCTTACAACC CCTACAAGTA CTCTGACGAC 
AACCCTTATT ACAACTACTA CGATACTTAT GAAAGGCCCA GACCTGGGGG CAGGTACCGG 
CCCGGATACG GCACTGGCTA CTTCCAGTAC GGTCTCCCAG ACCTGGTGGC CGACCCCTAC 
TACATCCAGG CGTCCACGTA CGTGCAGAAG ATGTCCATGT ACAACCTGAG ATGCGCGGCG 
GAGGAAAACT GTCTGGCCAG TACAGCATAC AGGGCAGATG TCAGAGATTA TGATCACAGG 
GTGCTGCTCA GATTTCCCCA AAGAGTGAAA AACCAAGGGA CATCAGATTT CTTACCCAGC 
CGACCAAGAT ATTCCTGGGA ATGGCACAGT TGTCATCAAC ATTACCACAG TATGGATGAG 
TTTAGCCACT ATGACCTGCT TGATGCCAAC ACCCAGAGGA GAGTGGCTGA AGGCCACAAA 
GCAAGTTTCT GTCTTGAAGA CACATCCTGT GACTATGGCT ACCACAGGCG ATTTGCATGT 
ACTGCACACA CACAGGGATT GAGTCCTGGC TGTTATGATA CCTATGGTGC AGACATAGAC 
TGCCAGTGGA TTGATATTAC AGATGTAAAA CCTGGAAACT ATATCCTAAA GGTCAGTGTA 
AACCCCAGCT ACCTGGTTCC TGAATCTGAC TATACCAACA ATGTTGTGCG CTGTGACATT 
CGCTACACAG GACATCATGC GTATGCCTCA GGCTGCACAA TTTCACCGTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LOX ( NM_002317.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_002308.2 Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21781
Clone ID Related Accession (Same CDS sequence)	NM_002317.6 , NM_002317.5 , NM_002317.7
Accession Version	NM_002317.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	protein-lysine 6-oxidase isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC299494.1, BC089436.1, AK307732.1, AC010255.9 and AI351010.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002317.6. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.12617.1, SRR1660805.180662.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000231004.5/ ENSP00000231004.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGCTTCG CCTGGACCGT GCTCCTGCTC GGGCCTTTGC AGCTCTGCGC GCTAGTGCAC 
TGCGCCCCTC CCGCCGCCGG CCAACAGCAG CCCCCGCGCG AGCCGCCGGC GGCTCCGGGC 
GCCTGGCGCC AGCAGATCCA ATGGGAGAAC AACGGGCAGG TGTTCAGCTT GCTGAGCCTG 
GGCTCACAGT ACCAGCCTCA GCGCCGCCGG GACCCGGGCG CCGCCGTCCC TGGTGCAGCC 
AACGCCTCCG CCCAGCAGCC CCGCACTCCG ATCCTGCTGA TCCGCGACAA CCGCACCGCC 
GCGGCGCGAA CGCGGACGGC CGGCTCATCT GGAGTCACCG CTGGCCGCCC CAGGCCCACC 
GCCCGTCACT GGTTCCAAGC TGGCTACTCG ACATCTAGAG CCCGCGAAGC TGGCGCCTCG 
CGCGCGGAGA ACCAGACAGC GCCGGGAGAA GTTCCTGCGC TCAGTAACCT GCGGCCGCCC 
AGCCGCGTGG ACGGCATGGT GGGCGACGAC CCTTACAACC CCTACAAGTA CTCTGACGAC 
AACCCTTATT ACAACTACTA CGATACTTAT GAAAGGCCCA GACCTGGGGG CAGGTACCGG 
CCCGGATACG GCACTGGCTA CTTCCAGTAC GGTCTCCCAG ACCTGGTGGC CGACCCCTAC 
TACATCCAGG CGTCCACGTA CGTGCAGAAG ATGTCCATGT ACAACCTGAG ATGCGCGGCG 
GAGGAAAACT GTCTGGCCAG TACAGCATAC AGGGCAGATG TCAGAGATTA TGATCACAGG 
GTGCTGCTCA GATTTCCCCA AAGAGTGAAA AACCAAGGGA CATCAGATTT CTTACCCAGC 
CGACCAAGAT ATTCCTGGGA ATGGCACAGT TGTCATCAAC ATTACCACAG TATGGATGAG 
TTTAGCCACT ATGACCTGCT TGATGCCAAC ACCCAGAGGA GAGTGGCTGA AGGCCACAAA 
GCAAGTTTCT GTCTTGAAGA CACATCCTGT GACTATGGCT ACCACAGGCG ATTTGCATGT 
ACTGCACACA CACAGGGATT GAGTCCTGGC TGTTATGATA CCTATGGTGC AGACATAGAC 
TGCCAGTGGA TTGATATTAC AGATGTAAAA CCTGGAAACT ATATCCTAAA GGTCAGTGTA 
AACCCCAGCT ACCTGGTTCC TGAATCTGAC TATACCAACA ATGTTGTGCG CTGTGACATT 
CGCTACACAG GACATCATGC GTATGCCTCA GGCTGCACAA TTTCACCGTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002308.2
CDS	275..1528
Translation	MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Target ORF information:

RefSeq Version	NM_002317.7
Organism	Homo sapiens(human)
Definition	Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002317.7

ORF Insert Sequence:

ATGCGCTTCG CCTGGACCGT GCTCCTGCTC GGGCCTTTGC AGCTCTGCGC GCTAGTGCAC 
TGCGCCCCTC CCGCCGCCGG CCAACAGCAG CCCCCGCGCG AGCCGCCGGC GGCTCCGGGC 
GCCTGGCGCC AGCAGATCCA ATGGGAGAAC AACGGGCAGG TGTTCAGCTT GCTGAGCCTG 
GGCTCACAGT ACCAGCCTCA GCGCCGCCGG GACCCGGGCG CCGCCGTCCC TGGTGCAGCC 
AACGCCTCCG CCCAGCAGCC CCGCACTCCG ATCCTGCTGA TCCGCGACAA CCGCACCGCC 
GCGGCGCGAA CGCGGACGGC CGGCTCATCT GGAGTCACCG CTGGCCGCCC CAGGCCCACC 
GCCCGTCACT GGTTCCAAGC TGGCTACTCG ACATCTAGAG CCCGCGAAGC TGGCGCCTCG 
CGCGCGGAGA ACCAGACAGC GCCGGGAGAA GTTCCTGCGC TCAGTAACCT GCGGCCGCCC 
AGCCGCGTGG ACGGCATGGT GGGCGACGAC CCTTACAACC CCTACAAGTA CTCTGACGAC 
AACCCTTATT ACAACTACTA CGATACTTAT GAAAGGCCCA GACCTGGGGG CAGGTACCGG 
CCCGGATACG GCACTGGCTA CTTCCAGTAC GGTCTCCCAG ACCTGGTGGC CGACCCCTAC 
TACATCCAGG CGTCCACGTA CGTGCAGAAG ATGTCCATGT ACAACCTGAG ATGCGCGGCG 
GAGGAAAACT GTCTGGCCAG TACAGCATAC AGGGCAGATG TCAGAGATTA TGATCACAGG 
GTGCTGCTCA GATTTCCCCA AAGAGTGAAA AACCAAGGGA CATCAGATTT CTTACCCAGC 
CGACCAAGAT ATTCCTGGGA ATGGCACAGT TGTCATCAAC ATTACCACAG TATGGATGAG 
TTTAGCCACT ATGACCTGCT TGATGCCAAC ACCCAGAGGA GAGTGGCTGA AGGCCACAAA 
GCAAGTTTCT GTCTTGAAGA CACATCCTGT GACTATGGCT ACCACAGGCG ATTTGCATGT 
ACTGCACACA CACAGGGATT GAGTCCTGGC TGTTATGATA CCTATGGTGC AGACATAGAC 
TGCCAGTGGA TTGATATTAC AGATGTAAAA CCTGGAAACT ATATCCTAAA GGTCAGTGTA 
AACCCCAGCT ACCTGGTTCC TGAATCTGAC TATACCAACA ATGTTGTGCG CTGTGACATT 
CGCTACACAG GACATCATGC GTATGCCTCA GGCTGCACAA TTTCACCGTA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer.
Cancer science110(12)3727-3737(2019 Dec)
Kalikawe R,Baba Y,Nomoto D,Okadome K,Miyake K,Eto K,Hiyoshi Y,Nagai Y,Iwatsuki M,Ishimoto T,Iwagami S,Miyamoto Y,Yoshida N,Watanabe M,Baba H

Forkhead box C1 promotes metastasis and invasion of non-small cell lung cancer by binding directly to the lysyl oxidase promoter.
Cancer science110(12)3663-3676(2019 Dec)
Gong R,Lin W,Gao A,Liu Y,Li J,Sun M,Chen X,Han S,Men C,Sun Y,Liu J

Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.
The Journal of biological chemistry294(29)11087-11100(2019 Jul)
Rosell-García T,Paradela A,Bravo G,Dupont L,Bekhouche M,Colige A,Rodriguez-Pascual F

Lysyl oxidase and hypoxia-inducible factor 1α: biomarkers of gastric cancer.
World journal of gastroenterology25(15)1828-1839(2019 Apr)
Han YL,Chen L,Qin R,Wang GQ,Lin XH,Dai GH

A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans.
Yonsei medical journal58(5)1006-1011(2017 Sep)
Hong EP,Jeon JP,Kim SE,Yang JS,Choi HJ,Kang SH,Cho YJ

REQUEST A QUOTE

EMAIL

gene@genscript.com

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

LOX cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM