RND3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RND3
Entrez Gene ID	390
Full Name	Rho family GTPase 3
Synonyms	ARHE,Rho8,RhoE,memB
General protein information	Preferred Names Rho family GTPase 3 Names rho-related GTP-binding protein RhoE protein MemB ras homolog gene family, member E rho-related GTP-binding protein Rho8 small GTP binding protein Rho8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q23.3
Summary	This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011].
Disorder MIM:	602924

mRNA and Protein(s)

mRNA	Protein	Name
NM_005168.4	NP_005159.1	rho-related GTP-binding protein RhoE precursor
NM_001254738.1	NP_001241667.1	rho-related GTP-binding protein RhoE precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	RND3	XP_422158.2
Pan troglodytes (chimpanzee)	RND3	XP_001135812.1
Macaca mulatta (Rhesus monkey)	RND3	XP_001082603.1
Xenopus tropicalis (tropical clawed frog)	rnd3	NP_001004920.1
Homo sapiens (human)	RND3	NP_005159.1
Mus musculus (house mouse)	Rnd3	NP_083086.1
Rattus norvegicus (Norway rat)	Rnd3	NP_001007642.1
Danio rerio (zebrafish)	rnd3a	NP_955816.1
Canis lupus familiaris (dog)	LOC483917	XP_541037.2
Bos taurus (cattle)	RND3	NP_001178087.1

Gene Ontology
Bibliography

Related articles in PubMed

Small GTPase RHOE/RND3, a new critical regulator of NF-κB signalling in glioblastoma multiforme?
Sun Q, Dong H, Li Y, Yuan F, Xu Y, Mao S, Xiong X, Chen Q, Liu B
Cell proliferation52(5)e12665(2019 Sep)

RhoE Fine-Tunes Inflammatory Response in Myocardial Infarction.
Dai Y, Song J, Li W, Yang T, Yue X, Lin X, Yang X, Luo W, Guo J, Wang X, Lai S, Andrade KC, Chang J
Circulation139(9)1185-1198(2019 02)

miR-200b/c targets the expression of RhoE and inhibits the proliferation and invasion of non-small cell lung cancer cells.
Tang Q, Li M, Chen L, Bi F, Xia H
International journal of oncology53(4)1732-1742(2018 Oct)

Highly expressed miR-182-5p can promote preeclampsia progression by degrading RND3 and inhibiting HTR-8/SVneo cell invasion.
Fang YN, Huang ZL, Li H, Tan WB, Zhang QG, Wang L, Wu JL
European review for medical and pharmacological sciences22(20)6583-6590(2018 10)

Rnd3/RhoE expression is regulated by G-actin through MKL1-SRF signaling pathway.
Piquet L, Robbe T, Neaud V, Basbous S, Rosciglione S, Saltel F, Moreau V
Experimental cell research370(2)227-236(2018 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RND3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RND3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu11915	NM_001254738.1 Latest version!	Homo sapiens Rho family GTPase 3 (RND3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$104.30 $149.00
OHu11915	NM_005168.4 Latest version!	Homo sapiens Rho family GTPase 3 (RND3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$104.30 $149.00

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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RND3 ( NM_005168.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005159.1 Homo sapiens Rho family GTPase 3 (RND3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11915
Clone ID Related Accession (Same CDS sequence)	NM_005168.4 , NM_001254738.1
Accession Version	NM_005168.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoE precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC367501.1, BC012513.1, BX460517.2 and CF127383.1. On Dec 15, 2011 this sequence version replaced NM_005168.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012513.1, SRR1660809.150771.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGAAGGAGA GAAGAGCCAG CCAGAAATTA TCCAGCAAAT CTATCATGGA TCCTAATCAG 
AACGTGAAAT GCAAGATAGT TGTGGTGGGA GACAGTCAGT GTGGAAAAAC TGCGCTGCTC 
CATGTCTTCG CCAAGGACTG CTTCCCCGAG AATTACGTTC CTACAGTGTT TGAGAATTAC 
ACGGCCAGTT TTGAAATCGA CACACAAAGA ATAGAGTTGA GCCTGTGGGA CACTTCGGGT 
TCTCCTTACT ATGACAATGT CCGCCCCCTC TCTTACCCTG ATTCGGATGC TGTGCTGATT 
TGCTTTGACA TCAGTAGACC AGAGACCCTG GACAGTGTCC TCAAAAAGTG GAAAGGTGAA 
ATCCAGGAAT TTTGTCCAAA TACCAAAATG CTCTTGGTCG GCTGCAAGTC TGATCTGCGG 
ACAGATGTTA GTACATTAGT AGAGCTCTCC AATCACAGGC AGACGCCAGT GTCCTATGAC 
CAGGGGGCAA ATATGGCCAA ACAGATTGGA GCAGCTACTT ATATCGAATG CTCAGCTTTA 
CAGTCGGAAA ATAGCGTCAG AGACATTTTT CACGTTGCCA CCTTGGCATG TGTAAATAAG 
ACAAATAAAA ACGTTAAGCG GAACAAATCA CAGAGAGCCA CAAAGCGGAT TTCACACATG 
CCTAGCAGAC CAGAACTCTC GGCAGTTGCT ACGGACTTAC GAAAGGACAA AGCGAAGAGC 
TGCACTGTGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005159.1
CDS	186..920
Translation	MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRISHMPSRPELSAVATDLRKDKAKSCTVM

Target ORF information:

RefSeq Version	NM_005168.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho family GTPase 3 (RND3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005168.4

ORF Insert Sequence:

ATGAAGGAGA GAAGAGCCAG CCAGAAATTA TCCAGCAAAT CTATCATGGA TCCTAATCAG 
AACGTGAAAT GCAAGATAGT TGTGGTGGGA GACAGTCAGT GTGGAAAAAC TGCGCTGCTC 
CATGTCTTCG CCAAGGACTG CTTCCCCGAG AATTACGTTC CTACAGTGTT TGAGAATTAC 
ACGGCCAGTT TTGAAATCGA CACACAAAGA ATAGAGTTGA GCCTGTGGGA CACTTCGGGT 
TCTCCTTACT ATGACAATGT CCGCCCCCTC TCTTACCCTG ATTCGGATGC TGTGCTGATT 
TGCTTTGACA TCAGTAGACC AGAGACCCTG GACAGTGTCC TCAAAAAGTG GAAAGGTGAA 
ATCCAGGAAT TTTGTCCAAA TACCAAAATG CTCTTGGTCG GCTGCAAGTC TGATCTGCGG 
ACAGATGTTA GTACATTAGT AGAGCTCTCC AATCACAGGC AGACGCCAGT GTCCTATGAC 
CAGGGGGCAA ATATGGCCAA ACAGATTGGA GCAGCTACTT ATATCGAATG CTCAGCTTTA 
CAGTCGGAAA ATAGCGTCAG AGACATTTTT CACGTTGCCA CCTTGGCATG TGTAAATAAG 
ACAAATAAAA ACGTTAAGCG GAACAAATCA CAGAGAGCCA CAAAGCGGAT TTCACACATG 
CCTAGCAGAC CAGAACTCTC GGCAGTTGCT ACGGACTTAC GAAAGGACAA AGCGAAGAGC 
TGCACTGTGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RND3 ( NM_001254738.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001241667.1 Homo sapiens Rho family GTPase 3 (RND3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11915
Clone ID Related Accession (Same CDS sequence)	NM_005168.4 , NM_001254738.1
Accession Version	NM_001254738.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein RhoE precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC074097.6, AK313224.1 and AC093738.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.129504.1, SRR1660807.131610.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAAGGAGA GAAGAGCCAG CCAGAAATTA TCCAGCAAAT CTATCATGGA TCCTAATCAG 
AACGTGAAAT GCAAGATAGT TGTGGTGGGA GACAGTCAGT GTGGAAAAAC TGCGCTGCTC 
CATGTCTTCG CCAAGGACTG CTTCCCCGAG AATTACGTTC CTACAGTGTT TGAGAATTAC 
ACGGCCAGTT TTGAAATCGA CACACAAAGA ATAGAGTTGA GCCTGTGGGA CACTTCGGGT 
TCTCCTTACT ATGACAATGT CCGCCCCCTC TCTTACCCTG ATTCGGATGC TGTGCTGATT 
TGCTTTGACA TCAGTAGACC AGAGACCCTG GACAGTGTCC TCAAAAAGTG GAAAGGTGAA 
ATCCAGGAAT TTTGTCCAAA TACCAAAATG CTCTTGGTCG GCTGCAAGTC TGATCTGCGG 
ACAGATGTTA GTACATTAGT AGAGCTCTCC AATCACAGGC AGACGCCAGT GTCCTATGAC 
CAGGGGGCAA ATATGGCCAA ACAGATTGGA GCAGCTACTT ATATCGAATG CTCAGCTTTA 
CAGTCGGAAA ATAGCGTCAG AGACATTTTT CACGTTGCCA CCTTGGCATG TGTAAATAAG 
ACAAATAAAA ACGTTAAGCG GAACAAATCA CAGAGAGCCA CAAAGCGGAT TTCACACATG 
CCTAGCAGAC CAGAACTCTC GGCAGTTGCT ACGGACTTAC GAAAGGACAA AGCGAAGAGC 
TGCACTGTGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001241667.1
CDS	279..1013
Translation	MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRISHMPSRPELSAVATDLRKDKAKSCTVM

Target ORF information:

RefSeq Version	NM_001254738.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho family GTPase 3 (RND3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001254738.1

ORF Insert Sequence:

ATGAAGGAGA GAAGAGCCAG CCAGAAATTA TCCAGCAAAT CTATCATGGA TCCTAATCAG 
AACGTGAAAT GCAAGATAGT TGTGGTGGGA GACAGTCAGT GTGGAAAAAC TGCGCTGCTC 
CATGTCTTCG CCAAGGACTG CTTCCCCGAG AATTACGTTC CTACAGTGTT TGAGAATTAC 
ACGGCCAGTT TTGAAATCGA CACACAAAGA ATAGAGTTGA GCCTGTGGGA CACTTCGGGT 
TCTCCTTACT ATGACAATGT CCGCCCCCTC TCTTACCCTG ATTCGGATGC TGTGCTGATT 
TGCTTTGACA TCAGTAGACC AGAGACCCTG GACAGTGTCC TCAAAAAGTG GAAAGGTGAA 
ATCCAGGAAT TTTGTCCAAA TACCAAAATG CTCTTGGTCG GCTGCAAGTC TGATCTGCGG 
ACAGATGTTA GTACATTAGT AGAGCTCTCC AATCACAGGC AGACGCCAGT GTCCTATGAC 
CAGGGGGCAA ATATGGCCAA ACAGATTGGA GCAGCTACTT ATATCGAATG CTCAGCTTTA 
CAGTCGGAAA ATAGCGTCAG AGACATTTTT CACGTTGCCA CCTTGGCATG TGTAAATAAG 
ACAAATAAAA ACGTTAAGCG GAACAAATCA CAGAGAGCCA CAAAGCGGAT TTCACACATG 
CCTAGCAGAC CAGAACTCTC GGCAGTTGCT ACGGACTTAC GAAAGGACAA AGCGAAGAGC 
TGCACTGTGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Small GTPase RHOE/RND3, a new critical regulator of NF-κB signalling in glioblastoma multiforme?
Cell proliferation52(5)e12665(2019 Sep)
Sun Q,Dong H,Li Y,Yuan F,Xu Y,Mao S,Xiong X,Chen Q,Liu B

RhoE Fine-Tunes Inflammatory Response in Myocardial Infarction.
Circulation139(9)1185-1198(2019 02)
Dai Y,Song J,Li W,Yang T,Yue X,Lin X,Yang X,Luo W,Guo J,Wang X,Lai S,Andrade KC,Chang J

miR-200b/c targets the expression of RhoE and inhibits the proliferation and invasion of non-small cell lung cancer cells.
International journal of oncology53(4)1732-1742(2018 Oct)
Tang Q,Li M,Chen L,Bi F,Xia H

Highly expressed miR-182-5p can promote preeclampsia progression by degrading RND3 and inhibiting HTR-8/SVneo cell invasion.
European review for medical and pharmacological sciences22(20)6583-6590(2018 10)
Fang YN,Huang ZL,Li H,Tan WB,Zhang QG,Wang L,Wu JL

Rnd3/RhoE expression is regulated by G-actin through MKL1-SRF signaling pathway.
Experimental cell research370(2)227-236(2018 09)
Piquet L,Robbe T,Neaud V,Basbous S,Rosciglione S,Saltel F,Moreau V

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RND3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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