PROB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PROB1
Entrez Gene ID	389333
Full Name	proline rich basic protein 1
Synonyms	C5orf65
General protein information	Preferred Names proline rich basic protein 1 Names proline-rich basic protein 1 weakly similar to basic proline-rich protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001161546.2	NP_001155018.1	proline-rich basic protein 1
NM_001161546.1	NP_001155018.1	proline-rich basic protein 1

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	LOC693695	XP_001083163.1
Bos taurus (cattle)	PROB1	XP_003586356.1
Pan troglodytes (chimpanzee)	PROB1	XP_003950689.1
Homo sapiens (human)	PROB1	NP_001155018.1
Mus musculus (house mouse)	Prob1	NP_001257575.1
Rattus norvegicus (Norway rat)	Prob1	XP_001069975.1
Canis lupus familiaris (dog)	PROB1	XP_005617312.1

Gene Ontology
Bibliography

Related articles in PubMed

Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.
Karolak JA, Gambin T, Pitarque JA, Molinari A, Jhangiani S, Stankiewicz P, Lupski JR, Gajecka M
European journal of human genetics : EJHG25(1)73-78(2016 01)

Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.
Graubert TA, Payton MA, Shao J, Walgren RA, Monahan RS, Frater JL, Walshauser MA, Martin MG, Kasai Y, Walter MJ
PloS one4(2)e4583(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PROB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PROB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12366	NM_001161546.2 Latest version!	Homo sapiens proline rich basic protein 1 (PROB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
View Old Accession Versions >>
OHu12366	NM_001161546.1	Homo sapiens proline rich basic protein 1 (PROB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PROB1 ( NM_001161546.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001155018.1 Homo sapiens proline rich basic protein 1 (PROB1), mRNA.

Price & Availability↑

CloneID	OHu12366
Clone ID Related Accession (Same CDS sequence)	NM_001161546.2 , NM_001161546.1
Accession Version	NM_001161546.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3048bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571846400000
Organism	Homo sapiens(human)
Product	proline-rich basic protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW576390.1, AC135457.2 and AK316483.1. On May 17, 2019 this sequence version replaced NM_001161546.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000434752.4/ ENSP00000416033.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCTGACCG CGCTCGCCCC GCCAGCCCTG CCTGGGATCC CGAGGCAGCT GCCCACGGCC 
CCCGCGCGGC GCCAGGACTC CTCCGGTTCG TCAGGCTCCT ACTACACGGC TCCAGGTTCT 
CCGGAGCCCC CGGACGTTGG GCCGGACGCG AAAGGCCCAG CGAATTGGCC CTGGGTGGCT 
CCTGGGCGGG GGGCGGGCGC GCAGCCTCGC CTGTCCGTCA GCGCCCAGAA TAGCCGCCAG 
CGGCACGGGC CCGGCTCGGG TTTCCCGCGA GGCCCAGGTT CCGGCCCACG GCCACCCCAG 
CCCCAGCTGC GCACGCTGCC GTCGGGGGAG ATGGAAGTCA TCTTCGGCGT CGGACCCCTG 
TTCGGCTGCT CCGGCGCAGA CGATCGCGAG GCGCAACAAC AGTTCACGGA GCCGGCCTTC 
ATCAGCCCCT TGCCGCCGGG GCCAGCGTCT CCCGCCGCGG TCCCACGCCA GTCCCAGGTC 
CCCGATGGTG GCTCCCGCTG GGCCACCTAC CTAGAGCTGC GGCCCCGTGG GCCAAGTCCT 
GCCGCCCCAG CGCAGTTCGA GTGTGTGGAG GTGGCTCTGG AGGAGGGCGC CGCGCCCGCC 
AGGCCCCGGA CAGTGCCCAA GCGTCAGATC GAGCTGCGCC CCCGGCCCCA GAGTCCCCCA 
AGGGCGGCCG GCGCGCCGCG CCCCCGGCTG CTCCTGCGCA CCGGTTCCCT GGACGAGTCG 
CTGGGCCCCC TGCAGGCCGC CGCGGGCTTC GTGCAGACGG CGTTGGCCAG AAAACTGAGC 
CCCGAGGCCC CGGCCCCGAG CAGCGCCACC TTCGGGTCCA CGGGGCGGTC GGAACCTGAG 
ACCCGGGAAA CGGCCCGCAG CACCCACGTG GTCCTGGAGA AGGCTAAGTC TCGGCCACTT 
CGCGTACGAG ATAATTCGGC CCCCGCCAAG GCCCCGAGGC CGTGGCCCAG CCTCCGCGAG 
CGCGCGATTC GGCGCGACAA GCCTGCGCCC GGGACGGAGC CGCTGGGTCC TGTTAGTTCC 
AGCATCTTCC TTCAGTCAGA GGAGAAGATC CAGGAGGCGC GGAAGACTCG GTTCCCGCGA 
GAGGCGCCGG ATCGAACTGT TCAGAGGGCA CGGAGTCCGC CTTTTGAGTG TAGGATCCCC 
TCGGAGGTTC CGAGTAGGGC TGTGAGGCCA AGGAGCCCGT CCCCGCCACG GCAGACTCCA 
AATGGGGCTG TACGGGGTCC TCGCTGCCCG TCGCCCCAGA ACCTGTCCCC GTGGGATCGG 
ACTACTCGGA GGGTGAGTAG CCCATTGTTC CCTGAAGCCT CCTCCGAGTG GGAAAATCAA 
AATCCTGCCG TCGAGGAAAC TGTCAGCAGG AGAAGCCCTT CCCCTCCGAT CCTTTCCCAG 
TGGAATCAGT GTGTTGCTGG GGAAAGGAGC CCGTCCCTCG AAGCCCCTTC CCTGTGGGAG 
ATTCCACATT CGGCAGTCGC GGATGCGGTG GAGCCACGTA GCAGCCCGTC CCCGCCGGCC 
TTCTTCCCGT GGGAGGCTCC AGATCGTCCT ATTGGAACTT GGGGCCCATC TCCCCAAGAG 
ACATGGGATC CCATGGGGCC GGGCTCATCG ATAGCATTTA CTCAGGAAGC TCAGAATGGG 
TTAACTCAGG AGGAGTTGGC ACCGCCTACA CCGTCCGCAC CCGGCACTCC AGAACCAACA 
GAGATGCAGA GTCCATCCAC GCGGGAAATT TCAGATCTTG CCTTTGGAGG GAGTCAGCAG 
TCCCCAGAGG TAGCAGCACC CGAGCCGCCC GGCAGCCACC CTGTGGGCAC CCTGGACGCG 
GATAAGTGCC CGGAAGTCTT GGGTCCTGGA GAGGCGGCCT CGGGACGCCC GCGCATGGCC 
ATTCCGCGGC CTCGAGACGT GCGCAAGTTG GTGAAGACCA CGTACGCGCC AGGCTTCCCG 
GCAGGAGCAC AAGGCTCTGG GCTGCCTGCG CCTCCTGCCG ACCCCTGCGG GGAGGAGGGC 
GGCGAATCCA AGACGCAAGA GCCGCCAGCA CTGGGGCCCC CCGCCCCGGC TCACTACACT 
TCCGTTTTCA TCAAGGATTT TCTACCGGTG GTGCCGCACC CCTACGAGCC TCCTGAACCG 
TCCTTCGACA CGGTCGCCCG GGACGCCTCA CAGCCCAACG GGGTCCTGCG GCGGAGGGCA 
GAGAACAGCA CGGCGAAGCC CTTCAAGCGC ACAGAGATCC GCCTGCCTGG GGCCCTGGCC 
TTGGGTCGCC GGCCCGAGGT AACCTCGCGA GTGCGAGCGC GCGGCCCTGG AGGAGAGAAC 
AGGGATGTAG AGGCCCAGCG CCTGGTCCCC GACGGCGACG GTCGGACCAG CCCTCTAGGC 
GGCGCCCGCA GCTCATCCCA GCGCTCCCCC GTAGGGCCAG CAGGGGTCCG ATCGCCCCGC 
CCCGGCTCCC CTCAGATGCA AGCCAGCCCG AGCCCTGGGA TAGCACCCAA ACCGAAGACA 
CCACCTACGG CCCCCGAGCC CGCGGCTGCC GTCCAGGCGC CACTCCCGCG GGAGCCCCTG 
GCGTTGGCGG GCAGGACGGC CCCAGCCCAG CCCCGCGCTG CCTCGGCGCC TCCCACGGAC 
CGGTCCCCGC AAAGCCCCTC CCAGGGAGCG CGCAGGCAGC CCGGGGCCGC GCCCCTGGGG 
AAGGTCTTGG TGGACCCCGA GAGCGGCCGC TACTACTTTG TGGAGGCGCC GCGGCAGCCT 
CGGCTGCGGG TGCTCTTCGA CCCTGAGAGT GGGCAGTACG TGGAGGTGTT GCTGCCGCCC 
TCGTCTCCCG GGCCGCCCCA CCGCGTCTAC ACCCCTCTGG CCCTGGGGCT CGGCCTCTAC 
CCGCCCGCCT ATGGGCCTAT ACCCAGCCTC TCTCTGCCAC CGTCCCCGGG CCCGCAGGCC 
CTCGGCAGCC CCCAGCTACC CTGGGTCTCT GAGGCAGGGC CCCTGGACGG GACCTACTAC 
CTGCCGGTGA GCGGGACCCC CAACCCCGCA CCTCCTCTGC TCCTCTGTGC GCCGCCCTCC 
AGCTCAGGTC CCACCCAGCC CGGCAAGGGT TCATTGTTCC CGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001155018.1
CDS	24..3071
Translation	MLTALAPPALPGIPRQLPTAPARRQDSSGSSGSYYTAPGSPEPPDVGPDAKGPANWPWVAPGRGAGAQPRLSVSAQNSRQRHGPGSGFPRGPGSGPRPPQPQLRTLPSGEMEVIFGVGPLFGCSGADDREAQQQFTEPAFISPLPPGPASPAAVPRQSQVPDGGSRWATYLELRPRGPSPAAPAQFECVEVALEEGAAPARPRTVPKRQIELRPRPQSPPRAAGAPRPRLLLRTGSLDESLGPLQAAAGFVQTALARKLSPEAPAPSSATFGSTGRSEPETRETARSTHVVLEKAKSRPLRVRDNSAPAKAPRPWPSLRERAIRRDKPAPGTEPLGPVSSSIFLQSEEKIQEARKTRFPREAPDRTVQRARSPPFECRIPSEVPSRAVRPRSPSPPRQTPNGAVRGPRCPSPQNLSPWDRTTRRVSSPLFPEASSEWENQNPAVEETVSRRSPSPPILSQWNQCVAGERSPSLEAPSLWEIPHSAVADAVEPRSSPSPPAFFPWEAPDRPIGTWGPSPQETWDPMGPGSSIAFTQEAQNGLTQEELAPPTPSAPGTPEPTEMQSPSTREISDLAFGGSQQSPEVAAPEPPGSHPVGTLDADKCPEVLGPGEAASGRPRMAIPRPRDVRKLVKTTYAPGFPAGAQGSGLPAPPADPCGEEGGESKTQEPPALGPPAPAHYTSVFIKDFLPVVPHPYEPPEPSFDTVARDASQPNGVLRRRAENSTAKPFKRTEIRLPGALALGRRPEVTSRVRARGPGGENRDVEAQRLVPDGDGRTSPLGGARSSSQRSPVGPAGVRSPRPGSPQMQASPSPGIAPKPKTPPTAPEPAAAVQAPLPREPLALAGRTAPAQPRAASAPPTDRSPQSPSQGARRQPGAAPLGKVLVDPESGRYYFVEAPRQPRLRVLFDPESGQYVEVLLPPSSPGPPHRVYTPLALGLGLYPPAYGPIPSLSLPPSPGPQALGSPQLPWVSEAGPLDGTYYLPVSGTPNPAPPLLLCAPPSSSGPTQPGKGSLFPL

Target ORF information:

RefSeq Version	NM_001161546.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich basic protein 1 (PROB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161546.2

ORF Insert Sequence:

ATGCTGACCG CGCTCGCCCC GCCAGCCCTG CCTGGGATCC CGAGGCAGCT GCCCACGGCC 
CCCGCGCGGC GCCAGGACTC CTCCGGTTCG TCAGGCTCCT ACTACACGGC TCCAGGTTCT 
CCGGAGCCCC CGGACGTTGG GCCGGACGCG AAAGGCCCAG CGAATTGGCC CTGGGTGGCT 
CCTGGGCGGG GGGCGGGCGC GCAGCCTCGC CTGTCCGTCA GCGCCCAGAA TAGCCGCCAG 
CGGCACGGGC CCGGCTCGGG TTTCCCGCGA GGCCCAGGTT CCGGCCCACG GCCACCCCAG 
CCCCAGCTGC GCACGCTGCC GTCGGGGGAG ATGGAAGTCA TCTTCGGCGT CGGACCCCTG 
TTCGGCTGCT CCGGCGCAGA CGATCGCGAG GCGCAACAAC AGTTCACGGA GCCGGCCTTC 
ATCAGCCCCT TGCCGCCGGG GCCAGCGTCT CCCGCCGCGG TCCCACGCCA GTCCCAGGTC 
CCCGATGGTG GCTCCCGCTG GGCCACCTAC CTAGAGCTGC GGCCCCGTGG GCCAAGTCCT 
GCCGCCCCAG CGCAGTTCGA GTGTGTGGAG GTGGCTCTGG AGGAGGGCGC CGCGCCCGCC 
AGGCCCCGGA CAGTGCCCAA GCGTCAGATC GAGCTGCGCC CCCGGCCCCA GAGTCCCCCA 
AGGGCGGCCG GCGCGCCGCG CCCCCGGCTG CTCCTGCGCA CCGGTTCCCT GGACGAGTCG 
CTGGGCCCCC TGCAGGCCGC CGCGGGCTTC GTGCAGACGG CGTTGGCCAG AAAACTGAGC 
CCCGAGGCCC CGGCCCCGAG CAGCGCCACC TTCGGGTCCA CGGGGCGGTC GGAACCTGAG 
ACCCGGGAAA CGGCCCGCAG CACCCACGTG GTCCTGGAGA AGGCTAAGTC TCGGCCACTT 
CGCGTACGAG ATAATTCGGC CCCCGCCAAG GCCCCGAGGC CGTGGCCCAG CCTCCGCGAG 
CGCGCGATTC GGCGCGACAA GCCTGCGCCC GGGACGGAGC CGCTGGGTCC TGTTAGTTCC 
AGCATCTTCC TTCAGTCAGA GGAGAAGATC CAGGAGGCGC GGAAGACTCG GTTCCCGCGA 
GAGGCGCCGG ATCGAACTGT TCAGAGGGCA CGGAGTCCGC CTTTTGAGTG TAGGATCCCC 
TCGGAGGTTC CGAGTAGGGC TGTGAGGCCA AGGAGCCCGT CCCCGCCACG GCAGACTCCA 
AATGGGGCTG TACGGGGTCC TCGCTGCCCG TCGCCCCAGA ACCTGTCCCC GTGGGATCGG 
ACTACTCGGA GGGTGAGTAG CCCATTGTTC CCTGAAGCCT CCTCCGAGTG GGAAAATCAA 
AATCCTGCCG TCGAGGAAAC TGTCAGCAGG AGAAGCCCTT CCCCTCCGAT CCTTTCCCAG 
TGGAATCAGT GTGTTGCTGG GGAAAGGAGC CCGTCCCTCG AAGCCCCTTC CCTGTGGGAG 
ATTCCACATT CGGCAGTCGC GGATGCGGTG GAGCCACGTA GCAGCCCGTC CCCGCCGGCC 
TTCTTCCCGT GGGAGGCTCC AGATCGTCCT ATTGGAACTT GGGGCCCATC TCCCCAAGAG 
ACATGGGATC CCATGGGGCC GGGCTCATCG ATAGCATTTA CTCAGGAAGC TCAGAATGGG 
TTAACTCAGG AGGAGTTGGC ACCGCCTACA CCGTCCGCAC CCGGCACTCC AGAACCAACA 
GAGATGCAGA GTCCATCCAC GCGGGAAATT TCAGATCTTG CCTTTGGAGG GAGTCAGCAG 
TCCCCAGAGG TAGCAGCACC CGAGCCGCCC GGCAGCCACC CTGTGGGCAC CCTGGACGCG 
GATAAGTGCC CGGAAGTCTT GGGTCCTGGA GAGGCGGCCT CGGGACGCCC GCGCATGGCC 
ATTCCGCGGC CTCGAGACGT GCGCAAGTTG GTGAAGACCA CGTACGCGCC AGGCTTCCCG 
GCAGGAGCAC AAGGCTCTGG GCTGCCTGCG CCTCCTGCCG ACCCCTGCGG GGAGGAGGGC 
GGCGAATCCA AGACGCAAGA GCCGCCAGCA CTGGGGCCCC CCGCCCCGGC TCACTACACT 
TCCGTTTTCA TCAAGGATTT TCTACCGGTG GTGCCGCACC CCTACGAGCC TCCTGAACCG 
TCCTTCGACA CGGTCGCCCG GGACGCCTCA CAGCCCAACG GGGTCCTGCG GCGGAGGGCA 
GAGAACAGCA CGGCGAAGCC CTTCAAGCGC ACAGAGATCC GCCTGCCTGG GGCCCTGGCC 
TTGGGTCGCC GGCCCGAGGT AACCTCGCGA GTGCGAGCGC GCGGCCCTGG AGGAGAGAAC 
AGGGATGTAG AGGCCCAGCG CCTGGTCCCC GACGGCGACG GTCGGACCAG CCCTCTAGGC 
GGCGCCCGCA GCTCATCCCA GCGCTCCCCC GTAGGGCCAG CAGGGGTCCG ATCGCCCCGC 
CCCGGCTCCC CTCAGATGCA AGCCAGCCCG AGCCCTGGGA TAGCACCCAA ACCGAAGACA 
CCACCTACGG CCCCCGAGCC CGCGGCTGCC GTCCAGGCGC CACTCCCGCG GGAGCCCCTG 
GCGTTGGCGG GCAGGACGGC CCCAGCCCAG CCCCGCGCTG CCTCGGCGCC TCCCACGGAC 
CGGTCCCCGC AAAGCCCCTC CCAGGGAGCG CGCAGGCAGC CCGGGGCCGC GCCCCTGGGG 
AAGGTCTTGG TGGACCCCGA GAGCGGCCGC TACTACTTTG TGGAGGCGCC GCGGCAGCCT 
CGGCTGCGGG TGCTCTTCGA CCCTGAGAGT GGGCAGTACG TGGAGGTGTT GCTGCCGCCC 
TCGTCTCCCG GGCCGCCCCA CCGCGTCTAC ACCCCTCTGG CCCTGGGGCT CGGCCTCTAC 
CCGCCCGCCT ATGGGCCTAT ACCCAGCCTC TCTCTGCCAC CGTCCCCGGG CCCGCAGGCC 
CTCGGCAGCC CCCAGCTACC CTGGGTCTCT GAGGCAGGGC CCCTGGACGG GACCTACTAC 
CTGCCGGTGA GCGGGACCCC CAACCCCGCA CCTCCTCTGC TCCTCTGTGC GCCGCCCTCC 
AGCTCAGGTC CCACCCAGCC CGGCAAGGGT TCATTGTTCC CGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PROB1 ( NM_001161546.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001155018.1 Homo sapiens proline rich basic protein 1 (PROB1), mRNA.

Price & Availability↑

CloneID	OHu12366
Clone ID Related Accession (Same CDS sequence)	NM_001161546.2 , NM_001161546.1
Accession Version	NM_001161546.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3048bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1529683200000
Organism	Homo sapiens(human)
Product	proline-rich basic protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW576390.1, AC135457.2 and AK316483.1. On or before Jul 18, 2009 this sequence version replaced XM_374142.4, XM_001721165.2, XM_001722732.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

ATGCTGACCG CGCTCGCCCC GCCAGCCCTG CCTGGGATCC CGAGGCAGCT GCCCACGGCC 
CCCGCGCGGC GCCAGGACTC CTCCGGTTCG TCAGGCTCCT ACTACACGGC TCCAGGTTCT 
CCGGAGCCCC CGGACGTTGG GCCGGACGCG AAAGGCCCAG CGAATTGGCC CTGGGTGGCT 
CCTGGGCGGG GGGCGGGCGC GCAGCCTCGC CTGTCCGTCA GCGCCCAGAA TAGCCGCCAG 
CGGCACGGGC CCGGCTCGGG TTTCCCGCGA GGCCCAGGTT CCGGCCCACG GCCACCCCAG 
CCCCAGCTGC GCACGCTGCC GTCGGGGGAG ATGGAAGTCA TCTTCGGCGT CGGACCCCTG 
TTCGGCTGCT CCGGCGCAGA CGATCGCGAG GCGCAACAAC AGTTCACGGA GCCGGCCTTC 
ATCAGCCCCT TGCCGCCGGG GCCAGCGTCT CCCGCCGCGG TCCCACGCCA GTCCCAGGTC 
CCCGATGGTG GCTCCCGCTG GGCCACCTAC CTAGAGCTGC GGCCCCGTGG GCCAAGTCCT 
GCCGCCCCAG CGCAGTTCGA GTGTGTGGAG GTGGCTCTGG AGGAGGGCGC CGCGCCCGCC 
AGGCCCCGGA CAGTGCCCAA GCGTCAGATC GAGCTGCGCC CCCGGCCCCA GAGTCCCCCA 
AGGGCGGCCG GCGCGCCGCG CCCCCGGCTG CTCCTGCGCA CCGGTTCCCT GGACGAGTCG 
CTGGGCCCCC TGCAGGCCGC CGCGGGCTTC GTGCAGACGG CGTTGGCCAG AAAACTGAGC 
CCCGAGGCCC CGGCCCCGAG CAGCGCCACC TTCGGGTCCA CGGGGCGGTC GGAACCTGAG 
ACCCGGGAAA CGGCCCGCAG CACCCACGTG GTCCTGGAGA AGGCTAAGTC TCGGCCACTT 
CGCGTACGAG ATAATTCGGC CCCCGCCAAG GCCCCGAGGC CGTGGCCCAG CCTCCGCGAG 
CGCGCGATTC GGCGCGACAA GCCTGCGCCC GGGACGGAGC CGCTGGGTCC TGTTAGTTCC 
AGCATCTTCC TTCAGTCAGA GGAGAAGATC CAGGAGGCGC GGAAGACTCG GTTCCCGCGA 
GAGGCGCCGG ATCGAACTGT TCAGAGGGCA CGGAGTCCGC CTTTTGAGTG TAGGATCCCC 
TCGGAGGTTC CGAGTAGGGC TGTGAGGCCA AGGAGCCCGT CCCCGCCACG GCAGACTCCA 
AATGGGGCTG TACGGGGTCC TCGCTGCCCG TCGCCCCAGA ACCTGTCCCC GTGGGATCGG 
ACTACTCGGA GGGTGAGTAG CCCATTGTTC CCTGAAGCCT CCTCCGAGTG GGAAAATCAA 
AATCCTGCCG TCGAGGAAAC TGTCAGCAGG AGAAGCCCTT CCCCTCCGAT CCTTTCCCAG 
TGGAATCAGT GTGTTGCTGG GGAAAGGAGC CCGTCCCTCG AAGCCCCTTC CCTGTGGGAG 
ATTCCACATT CGGCAGTCGC GGATGCGGTG GAGCCACGTA GCAGCCCGTC CCCGCCGGCC 
TTCTTCCCGT GGGAGGCTCC AGATCGTCCT ATTGGAACTT GGGGCCCATC TCCCCAAGAG 
ACATGGGATC CCATGGGGCC GGGCTCATCG ATAGCATTTA CTCAGGAAGC TCAGAATGGG 
TTAACTCAGG AGGAGTTGGC ACCGCCTACA CCGTCCGCAC CCGGCACTCC AGAACCAACA 
GAGATGCAGA GTCCATCCAC GCGGGAAATT TCAGATCTTG CCTTTGGAGG GAGTCAGCAG 
TCCCCAGAGG TAGCAGCACC CGAGCCGCCC GGCAGCCACC CTGTGGGCAC CCTGGACGCG 
GATAAGTGCC CGGAAGTCTT GGGTCCTGGA GAGGCGGCCT CGGGACGCCC GCGCATGGCC 
ATTCCGCGGC CTCGAGACGT GCGCAAGTTG GTGAAGACCA CGTACGCGCC AGGCTTCCCG 
GCAGGAGCAC AAGGCTCTGG GCTGCCTGCG CCTCCTGCCG ACCCCTGCGG GGAGGAGGGC 
GGCGAATCCA AGACGCAAGA GCCGCCAGCA CTGGGGCCCC CCGCCCCGGC TCACTACACT 
TCCGTTTTCA TCAAGGATTT TCTACCGGTG GTGCCGCACC CCTACGAGCC TCCTGAACCG 
TCCTTCGACA CGGTCGCCCG GGACGCCTCA CAGCCCAACG GGGTCCTGCG GCGGAGGGCA 
GAGAACAGCA CGGCGAAGCC CTTCAAGCGC ACAGAGATCC GCCTGCCTGG GGCCCTGGCC 
TTGGGTCGCC GGCCCGAGGT AACCTCGCGA GTGCGAGCGC GCGGCCCTGG AGGAGAGAAC 
AGGGATGTAG AGGCCCAGCG CCTGGTCCCC GACGGCGACG GTCGGACCAG CCCTCTAGGC 
GGCGCCCGCA GCTCATCCCA GCGCTCCCCC GTAGGGCCAG CAGGGGTCCG ATCGCCCCGC 
CCCGGCTCCC CTCAGATGCA AGCCAGCCCG AGCCCTGGGA TAGCACCCAA ACCGAAGACA 
CCACCTACGG CCCCCGAGCC CGCGGCTGCC GTCCAGGCGC CACTCCCGCG GGAGCCCCTG 
GCGTTGGCGG GCAGGACGGC CCCAGCCCAG CCCCGCGCTG CCTCGGCGCC TCCCACGGAC 
CGGTCCCCGC AAAGCCCCTC CCAGGGAGCG CGCAGGCAGC CCGGGGCCGC GCCCCTGGGG 
AAGGTCTTGG TGGACCCCGA GAGCGGCCGC TACTACTTTG TGGAGGCGCC GCGGCAGCCT 
CGGCTGCGGG TGCTCTTCGA CCCTGAGAGT GGGCAGTACG TGGAGGTGTT GCTGCCGCCC 
TCGTCTCCCG GGCCGCCCCA CCGCGTCTAC ACCCCTCTGG CCCTGGGGCT CGGCCTCTAC 
CCGCCCGCCT ATGGGCCTAT ACCCAGCCTC TCTCTGCCAC CGTCCCCGGG CCCGCAGGCC 
CTCGGCAGCC CCCAGCTACC CTGGGTCTCT GAGGCAGGGC CCCTGGACGG GACCTACTAC 
CTGCCGGTGA GCGGGACCCC CAACCCCGCA CCTCCTCTGC TCCTCTGTGC GCCGCCCTCC 
AGCTCAGGTC CCACCCAGCC CGGCAAGGGT TCATTGTTCC CGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001155018.1
CDS	116..3163
Translation	MLTALAPPALPGIPRQLPTAPARRQDSSGSSGSYYTAPGSPEPPDVGPDAKGPANWPWVAPGRGAGAQPRLSVSAQNSRQRHGPGSGFPRGPGSGPRPPQPQLRTLPSGEMEVIFGVGPLFGCSGADDREAQQQFTEPAFISPLPPGPASPAAVPRQSQVPDGGSRWATYLELRPRGPSPAAPAQFECVEVALEEGAAPARPRTVPKRQIELRPRPQSPPRAAGAPRPRLLLRTGSLDESLGPLQAAAGFVQTALARKLSPEAPAPSSATFGSTGRSEPETRETARSTHVVLEKAKSRPLRVRDNSAPAKAPRPWPSLRERAIRRDKPAPGTEPLGPVSSSIFLQSEEKIQEARKTRFPREAPDRTVQRARSPPFECRIPSEVPSRAVRPRSPSPPRQTPNGAVRGPRCPSPQNLSPWDRTTRRVSSPLFPEASSEWENQNPAVEETVSRRSPSPPILSQWNQCVAGERSPSLEAPSLWEIPHSAVADAVEPRSSPSPPAFFPWEAPDRPIGTWGPSPQETWDPMGPGSSIAFTQEAQNGLTQEELAPPTPSAPGTPEPTEMQSPSTREISDLAFGGSQQSPEVAAPEPPGSHPVGTLDADKCPEVLGPGEAASGRPRMAIPRPRDVRKLVKTTYAPGFPAGAQGSGLPAPPADPCGEEGGESKTQEPPALGPPAPAHYTSVFIKDFLPVVPHPYEPPEPSFDTVARDASQPNGVLRRRAENSTAKPFKRTEIRLPGALALGRRPEVTSRVRARGPGGENRDVEAQRLVPDGDGRTSPLGGARSSSQRSPVGPAGVRSPRPGSPQMQASPSPGIAPKPKTPPTAPEPAAAVQAPLPREPLALAGRTAPAQPRAASAPPTDRSPQSPSQGARRQPGAAPLGKVLVDPESGRYYFVEAPRQPRLRVLFDPESGQYVEVLLPPSSPGPPHRVYTPLALGLGLYPPAYGPIPSLSLPPSPGPQALGSPQLPWVSEAGPLDGTYYLPVSGTPNPAPPLLLCAPPSSSGPTQPGKGSLFPL

Target ORF information:

RefSeq Version	NM_001161546.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich basic protein 1 (PROB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161546.1

ORF Insert Sequence:

ATGCTGACCG CGCTCGCCCC GCCAGCCCTG CCTGGGATCC CGAGGCAGCT GCCCACGGCC 
CCCGCGCGGC GCCAGGACTC CTCCGGTTCG TCAGGCTCCT ACTACACGGC TCCAGGTTCT 
CCGGAGCCCC CGGACGTTGG GCCGGACGCG AAAGGCCCAG CGAATTGGCC CTGGGTGGCT 
CCTGGGCGGG GGGCGGGCGC GCAGCCTCGC CTGTCCGTCA GCGCCCAGAA TAGCCGCCAG 
CGGCACGGGC CCGGCTCGGG TTTCCCGCGA GGCCCAGGTT CCGGCCCACG GCCACCCCAG 
CCCCAGCTGC GCACGCTGCC GTCGGGGGAG ATGGAAGTCA TCTTCGGCGT CGGACCCCTG 
TTCGGCTGCT CCGGCGCAGA CGATCGCGAG GCGCAACAAC AGTTCACGGA GCCGGCCTTC 
ATCAGCCCCT TGCCGCCGGG GCCAGCGTCT CCCGCCGCGG TCCCACGCCA GTCCCAGGTC 
CCCGATGGTG GCTCCCGCTG GGCCACCTAC CTAGAGCTGC GGCCCCGTGG GCCAAGTCCT 
GCCGCCCCAG CGCAGTTCGA GTGTGTGGAG GTGGCTCTGG AGGAGGGCGC CGCGCCCGCC 
AGGCCCCGGA CAGTGCCCAA GCGTCAGATC GAGCTGCGCC CCCGGCCCCA GAGTCCCCCA 
AGGGCGGCCG GCGCGCCGCG CCCCCGGCTG CTCCTGCGCA CCGGTTCCCT GGACGAGTCG 
CTGGGCCCCC TGCAGGCCGC CGCGGGCTTC GTGCAGACGG CGTTGGCCAG AAAACTGAGC 
CCCGAGGCCC CGGCCCCGAG CAGCGCCACC TTCGGGTCCA CGGGGCGGTC GGAACCTGAG 
ACCCGGGAAA CGGCCCGCAG CACCCACGTG GTCCTGGAGA AGGCTAAGTC TCGGCCACTT 
CGCGTACGAG ATAATTCGGC CCCCGCCAAG GCCCCGAGGC CGTGGCCCAG CCTCCGCGAG 
CGCGCGATTC GGCGCGACAA GCCTGCGCCC GGGACGGAGC CGCTGGGTCC TGTTAGTTCC 
AGCATCTTCC TTCAGTCAGA GGAGAAGATC CAGGAGGCGC GGAAGACTCG GTTCCCGCGA 
GAGGCGCCGG ATCGAACTGT TCAGAGGGCA CGGAGTCCGC CTTTTGAGTG TAGGATCCCC 
TCGGAGGTTC CGAGTAGGGC TGTGAGGCCA AGGAGCCCGT CCCCGCCACG GCAGACTCCA 
AATGGGGCTG TACGGGGTCC TCGCTGCCCG TCGCCCCAGA ACCTGTCCCC GTGGGATCGG 
ACTACTCGGA GGGTGAGTAG CCCATTGTTC CCTGAAGCCT CCTCCGAGTG GGAAAATCAA 
AATCCTGCCG TCGAGGAAAC TGTCAGCAGG AGAAGCCCTT CCCCTCCGAT CCTTTCCCAG 
TGGAATCAGT GTGTTGCTGG GGAAAGGAGC CCGTCCCTCG AAGCCCCTTC CCTGTGGGAG 
ATTCCACATT CGGCAGTCGC GGATGCGGTG GAGCCACGTA GCAGCCCGTC CCCGCCGGCC 
TTCTTCCCGT GGGAGGCTCC AGATCGTCCT ATTGGAACTT GGGGCCCATC TCCCCAAGAG 
ACATGGGATC CCATGGGGCC GGGCTCATCG ATAGCATTTA CTCAGGAAGC TCAGAATGGG 
TTAACTCAGG AGGAGTTGGC ACCGCCTACA CCGTCCGCAC CCGGCACTCC AGAACCAACA 
GAGATGCAGA GTCCATCCAC GCGGGAAATT TCAGATCTTG CCTTTGGAGG GAGTCAGCAG 
TCCCCAGAGG TAGCAGCACC CGAGCCGCCC GGCAGCCACC CTGTGGGCAC CCTGGACGCG 
GATAAGTGCC CGGAAGTCTT GGGTCCTGGA GAGGCGGCCT CGGGACGCCC GCGCATGGCC 
ATTCCGCGGC CTCGAGACGT GCGCAAGTTG GTGAAGACCA CGTACGCGCC AGGCTTCCCG 
GCAGGAGCAC AAGGCTCTGG GCTGCCTGCG CCTCCTGCCG ACCCCTGCGG GGAGGAGGGC 
GGCGAATCCA AGACGCAAGA GCCGCCAGCA CTGGGGCCCC CCGCCCCGGC TCACTACACT 
TCCGTTTTCA TCAAGGATTT TCTACCGGTG GTGCCGCACC CCTACGAGCC TCCTGAACCG 
TCCTTCGACA CGGTCGCCCG GGACGCCTCA CAGCCCAACG GGGTCCTGCG GCGGAGGGCA 
GAGAACAGCA CGGCGAAGCC CTTCAAGCGC ACAGAGATCC GCCTGCCTGG GGCCCTGGCC 
TTGGGTCGCC GGCCCGAGGT AACCTCGCGA GTGCGAGCGC GCGGCCCTGG AGGAGAGAAC 
AGGGATGTAG AGGCCCAGCG CCTGGTCCCC GACGGCGACG GTCGGACCAG CCCTCTAGGC 
GGCGCCCGCA GCTCATCCCA GCGCTCCCCC GTAGGGCCAG CAGGGGTCCG ATCGCCCCGC 
CCCGGCTCCC CTCAGATGCA AGCCAGCCCG AGCCCTGGGA TAGCACCCAA ACCGAAGACA 
CCACCTACGG CCCCCGAGCC CGCGGCTGCC GTCCAGGCGC CACTCCCGCG GGAGCCCCTG 
GCGTTGGCGG GCAGGACGGC CCCAGCCCAG CCCCGCGCTG CCTCGGCGCC TCCCACGGAC 
CGGTCCCCGC AAAGCCCCTC CCAGGGAGCG CGCAGGCAGC CCGGGGCCGC GCCCCTGGGG 
AAGGTCTTGG TGGACCCCGA GAGCGGCCGC TACTACTTTG TGGAGGCGCC GCGGCAGCCT 
CGGCTGCGGG TGCTCTTCGA CCCTGAGAGT GGGCAGTACG TGGAGGTGTT GCTGCCGCCC 
TCGTCTCCCG GGCCGCCCCA CCGCGTCTAC ACCCCTCTGG CCCTGGGGCT CGGCCTCTAC 
CCGCCCGCCT ATGGGCCTAT ACCCAGCCTC TCTCTGCCAC CGTCCCCGGG CCCGCAGGCC 
CTCGGCAGCC CCCAGCTACC CTGGGTCTCT GAGGCAGGGC CCCTGGACGG GACCTACTAC 
CTGCCGGTGA GCGGGACCCC CAACCCCGCA CCTCCTCTGC TCCTCTGTGC GCCGCCCTCC 
AGCTCAGGTC CCACCCAGCC CGGCAAGGGT TCATTGTTCC CGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.
European journal of human genetics : EJHG25(1)73-78(2016 01)
Karolak JA,Gambin T,Pitarque JA,Molinari A,Jhangiani S,Stankiewicz P,Lupski JR,Gajecka M

Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.
PloS one4(2)e4583(2009)
Graubert TA,Payton MA,Shao J,Walgren RA,Monahan RS,Frater JL,Walshauser MA,Martin MG,Kasai Y,Walter MJ

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PROB1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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