KRT12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRT12
Entrez Gene ID	3859
Full Name	keratin 12
Synonyms	K12
General protein information	Preferred Names keratin 12 Names keratin, type I cytoskeletal 12 CK-12 cytokeratin-12 keratin 12, type I
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.2
Summary	KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008].
Disorder MIM:	601687
Disorder Html:	Meesmann corneal dystrophy, 122100 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000223.4	NP_000214.1	keratin, type I cytoskeletal 12
NM_000223.3	NP_000214.1	keratin, type I cytoskeletal 12

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	KRT12	XP_001101582.1
Bos taurus (cattle)	KRT12	XP_002696056.2
Rattus norvegicus (Norway rat)	Krt12	NP_001008761.1
Gallus gallus (chicken)	KRT12	XP_004948663.1
Xenopus tropicalis (tropical clawed frog)	LOC100486967	XP_002940696.1
Pan troglodytes (chimpanzee)	KRT12	XP_001168468.1
Mus musculus (house mouse)	Krt12	NP_034791.2
Canis lupus familiaris (dog)	KRT12	NP_001075890.1
Homo sapiens (human)	KRT12	NP_000214.1

Gene Ontology
Bibliography

Related articles in PubMed

In vivo histology and p.L132V mutation in KRT12 gene in Japanese patients with Meesmann corneal dystrophy.
Nishino T, Kobayashi A, Mori N, Masaki T, Yokogawa H, Fujiki K, Yanagawa A, Murakami A, Sugiyama K
Japanese journal of ophthalmology63(1)46-55(2019 Jan)

Human aniridia limbal epithelial cells lack expression of keratins K3 and K12.
Latta L, Viestenz A, Stachon T, Colanesi S, Szentmáry N, Seitz B, Käsmann-Kellner B
Experimental eye research167100-109(2018 02)

Mutation analysis of TGFBI and KRT12 in a case of concomitant keratoconus and granular corneal dystrophy.
Du X, Chen P, Sun D
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie255(9)1779-1786(2017 Sep)

PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific Genes.
Sasamoto Y, Hayashi R, Park SJ, Saito-Adachi M, Suzuki Y, Kawasaki S, Quantock AJ, Nakai K, Tsujikawa M, Nishida K
Scientific reports620807(2016 Feb)

siRNA silencing of the mutant keratin 12 allele in corneal limbal epithelial cells grown from patients with Meesmann's epithelial corneal dystrophy.
Courtney DG, Atkinson SD, Allen EH, Moore JE, Walsh CP, Pedrioli DM, MacEwen CJ, Pellegrini G, Maurizi E, Serafini C, Fantacci M, Liao H, Irvine AD, McLean WH, Moore CB
Investigative ophthalmology & visual science55(5)3352-60(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KRT12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18523	NM_000223.4 Latest version!	Homo sapiens keratin 12 (KRT12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$286.30 $409.00
View Old Accession Versions >>
OHu18523	NM_000223.3	Homo sapiens keratin 12 (KRT12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$286.30 $409.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRT12 ( NM_000223.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000214.1 Homo sapiens keratin 12 (KRT12), mRNA.

Price & Availability↑

CloneID	OHu18523
Clone ID Related Accession (Same CDS sequence)	NM_000223.4 , NM_000223.3
Accession Version	NM_000223.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Homo sapiens(human)
Product	keratin, type I cytoskeletal 12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313747.1, D78367.1 and CV573989.1. This sequence is a reference standard in the RefSeqGene project. On Jan 9, 2019 this sequence version replaced NM_000223.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D78367.1, AK313747.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000251643.5/ ENSP00000251643.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCTCT CCAACAACAC CATGTCACTC TCAGTGCGCA CCCCCGGACT GTCCCGGCGG 
CTCTCCTCGC AGAGTGTGAT AGGCAGACCC AGGGGCATGT CTGCTTCCAG TGTTGGAAGT 
GGTTATGGGG GAAGTGCCTT TGGCTTTGGA GCCAGCTGTG GGGGAGGCTT TTCTGCTGCT 
TCCATGTTTG GTTCTAGTTC CGGCTTTGGG GGTGGCTCCG GAAGTTCCAT GGCAGGAGGA 
CTGGGTGCTG GTTATGGGAG AGCCCTGGGT GGAGGTAGCT TTGGAGGGCT GGGGATGGGA 
TTTGGGGGCA GCCCAGGAGG TGGCTCTCTA GGTATTCTCT CGGGCAATGA TGGAGGCCTT 
CTTTCTGGAT CAGAAAAAGA AACTATGCAA AATCTTAATG ATAGATTAGC TTCCTACCTG 
GATAAGGTGC GAGCTCTAGA AGAGGCTAAT ACTGAGCTAG AAAATAAAAT TCGAGAATGG 
TATGAAACAC GAGGAACTGG GACTGCAGAT GCTTCACAGA GCGATTACAG CAAATATTAT 
CCACTGATTG AAGACCTCAG GAATAAGATC ATTTCAGCCA GCATTGGAAA TGCCCAGCTC 
CTCTTGCAGA TTGACAATGC GAGACTAGCT GCTGAGGACT TCAGGATGAA GTATGAGAAT 
GAACTGGCCC TGCGCCAGGG CGTAGAGGCC GACATCAATG GCCTGCGCCG GGTGCTGGAC 
GAGCTGACCC TGACCAGGAC CGACCTGGAG ATGCAGATCG AGAGCCTGAA CGAGGAGCTG 
GCCTACATGA AGAAGAACCA CGAGGATGAG CTCCAAAGCT TCCGGGTGGG CGGCCCAGGC 
GAGGTCAGCG TAGAAATGGA CGCTGCCCCC GGAGTGGACC TCACCAGGCT CCTCAATGAT 
ATGCGGGCGC AGTATGAAAC CATCGCTGAG CAGAATCGGA AGGACGCTGA AGCCTGGTTC 
ATTGAAAAGA GCGGGGAGCT CCGTAAGGAG ATTAGCACCA ACACCGAGCA GCTTCAGTCC 
AGCAAGAGCG AGGTCACCGA CCTGCGTCGC GCCTTTCAGA ACCTGGAGAT CGAGCTACAG 
TCCCAGCTCG CCATGAAGAA ATCCCTGGAG GACTCCTTGG CCGAAGCCGA GGGCGATTAC 
TGCGCGCAGC TGTCCCAGGT GCAGCAGCTC ATCAGCAACC TGGAGGCACA GCTGCTCCAG 
GTGCGCGCGG ACGCAGAGCG CCAGAACGTG GACCACCAGC GGCTGCTGAA TGTCAAGGCC 
CGCCTGGAGC TGGAGATTGA GACCTACCGC CGCCTGCTGG ACGGGGAGGC CCAAGGTGAT 
GGTTTGGAGG AAAGTTTATT TGTGACAGAC TCCAAATCAC AAGCACAGTC AACTGATTCC 
TCTAAAGACC CAACCAAAAC CCGAAAAATC AAGACAGTTG TGCAGGAGAT GGTGAATGGT 
GAGGTGGTCT CATCTCAAGT TCAGGAAATT GAAGAACTAA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000214.1
CDS	38..1522
Translation	MDLSNNTMSLSVRTPGLSRRLSSQSVIGRPRGMSASSVGSGYGGSAFGFGASCGGGFSAASMFGSSSGFGGGSGSSMAGGLGAGYGRALGGGSFGGLGMGFGGSPGGGSLGILSGNDGGLLSGSEKETMQNLNDRLASYLDKVRALEEANTELENKIREWYETRGTGTADASQSDYSKYYPLIEDLRNKIISASIGNAQLLLQIDNARLAAEDFRMKYENELALRQGVEADINGLRRVLDELTLTRTDLEMQIESLNEELAYMKKNHEDELQSFRVGGPGEVSVEMDAAPGVDLTRLLNDMRAQYETIAEQNRKDAEAWFIEKSGELRKEISTNTEQLQSSKSEVTDLRRAFQNLEIELQSQLAMKKSLEDSLAEAEGDYCAQLSQVQQLISNLEAQLLQVRADAERQNVDHQRLLNVKARLELEIETYRRLLDGEAQGDGLEESLFVTDSKSQAQSTDSSKDPTKTRKIKTVVQEMVNGEVVSSQVQEIEELM

Target ORF information:

RefSeq Version	NM_000223.4
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 12 (KRT12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000223.4

ORF Insert Sequence:

ATGGATCTCT CCAACAACAC CATGTCACTC TCAGTGCGCA CCCCCGGACT GTCCCGGCGG 
CTCTCCTCGC AGAGTGTGAT AGGCAGACCC AGGGGCATGT CTGCTTCCAG TGTTGGAAGT 
GGTTATGGGG GAAGTGCCTT TGGCTTTGGA GCCAGCTGTG GGGGAGGCTT TTCTGCTGCT 
TCCATGTTTG GTTCTAGTTC CGGCTTTGGG GGTGGCTCCG GAAGTTCCAT GGCAGGAGGA 
CTGGGTGCTG GTTATGGGAG AGCCCTGGGT GGAGGTAGCT TTGGAGGGCT GGGGATGGGA 
TTTGGGGGCA GCCCAGGAGG TGGCTCTCTA GGTATTCTCT CGGGCAATGA TGGAGGCCTT 
CTTTCTGGAT CAGAAAAAGA AACTATGCAA AATCTTAATG ATAGATTAGC TTCCTACCTG 
GATAAGGTGC GAGCTCTAGA AGAGGCTAAT ACTGAGCTAG AAAATAAAAT TCGAGAATGG 
TATGAAACAC GAGGAACTGG GACTGCAGAT GCTTCACAGA GCGATTACAG CAAATATTAT 
CCACTGATTG AAGACCTCAG GAATAAGATC ATTTCAGCCA GCATTGGAAA TGCCCAGCTC 
CTCTTGCAGA TTGACAATGC GAGACTAGCT GCTGAGGACT TCAGGATGAA GTATGAGAAT 
GAACTGGCCC TGCGCCAGGG CGTAGAGGCC GACATCAATG GCCTGCGCCG GGTGCTGGAC 
GAGCTGACCC TGACCAGGAC CGACCTGGAG ATGCAGATCG AGAGCCTGAA CGAGGAGCTG 
GCCTACATGA AGAAGAACCA CGAGGATGAG CTCCAAAGCT TCCGGGTGGG CGGCCCAGGC 
GAGGTCAGCG TAGAAATGGA CGCTGCCCCC GGAGTGGACC TCACCAGGCT CCTCAATGAT 
ATGCGGGCGC AGTATGAAAC CATCGCTGAG CAGAATCGGA AGGACGCTGA AGCCTGGTTC 
ATTGAAAAGA GCGGGGAGCT CCGTAAGGAG ATTAGCACCA ACACCGAGCA GCTTCAGTCC 
AGCAAGAGCG AGGTCACCGA CCTGCGTCGC GCCTTTCAGA ACCTGGAGAT CGAGCTACAG 
TCCCAGCTCG CCATGAAGAA ATCCCTGGAG GACTCCTTGG CCGAAGCCGA GGGCGATTAC 
TGCGCGCAGC TGTCCCAGGT GCAGCAGCTC ATCAGCAACC TGGAGGCACA GCTGCTCCAG 
GTGCGCGCGG ACGCAGAGCG CCAGAACGTG GACCACCAGC GGCTGCTGAA TGTCAAGGCC 
CGCCTGGAGC TGGAGATTGA GACCTACCGC CGCCTGCTGG ACGGGGAGGC CCAAGGTGAT 
GGTTTGGAGG AAAGTTTATT TGTGACAGAC TCCAAATCAC AAGCACAGTC AACTGATTCC 
TCTAAAGACC CAACCAAAAC CCGAAAAATC AAGACAGTTG TGCAGGAGAT GGTGAATGGT 
GAGGTGGTCT CATCTCAAGT TCAGGAAATT GAAGAACTAA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT12 ( NM_000223.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000214.1 Homo sapiens keratin 12 (KRT12), mRNA.

Price & Availability↑

CloneID	OHu18523
Clone ID Related Accession (Same CDS sequence)	NM_000223.4 , NM_000223.3
Accession Version	NM_000223.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1539273600000
Organism	Homo sapiens(human)
Product	keratin, type I cytoskeletal 12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D78367.1 and CV573989.1. This sequence is a reference standard in the RefSeqGene project. On Aug 29, 2007 this sequence version replaced NM_000223.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D78367.1, AK313747.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGATCTCT CCAACAACAC CATGTCACTC TCAGTGCGCA CCCCCGGACT GTCCCGGCGG 
CTCTCCTCGC AGAGTGTGAT AGGCAGACCC AGGGGCATGT CTGCTTCCAG TGTTGGAAGT 
GGTTATGGGG GAAGTGCCTT TGGCTTTGGA GCCAGCTGTG GGGGAGGCTT TTCTGCTGCT 
TCCATGTTTG GTTCTAGTTC CGGCTTTGGG GGTGGCTCCG GAAGTTCCAT GGCAGGAGGA 
CTGGGTGCTG GTTATGGGAG AGCCCTGGGT GGAGGTAGCT TTGGAGGGCT GGGGATGGGA 
TTTGGGGGCA GCCCAGGAGG TGGCTCTCTA GGTATTCTCT CGGGCAATGA TGGAGGCCTT 
CTTTCTGGAT CAGAAAAAGA AACTATGCAA AATCTTAATG ATAGATTAGC TTCCTACCTG 
GATAAGGTGC GAGCTCTAGA AGAGGCTAAT ACTGAGCTAG AAAATAAAAT TCGAGAATGG 
TATGAAACAC GAGGAACTGG GACTGCAGAT GCTTCACAGA GCGATTACAG CAAATATTAT 
CCACTGATTG AAGACCTCAG GAATAAGATC ATTTCAGCCA GCATTGGAAA TGCCCAGCTC 
CTCTTGCAGA TTGACAATGC GAGACTAGCT GCTGAGGACT TCAGGATGAA GTATGAGAAT 
GAACTGGCCC TGCGCCAGGG CGTAGAGGCC GACATCAATG GCCTGCGCCG GGTGCTGGAC 
GAGCTGACCC TGACCAGGAC CGACCTGGAG ATGCAGATCG AGAGCCTGAA CGAGGAGCTG 
GCCTACATGA AGAAGAACCA CGAGGATGAG CTCCAAAGCT TCCGGGTGGG CGGCCCAGGC 
GAGGTCAGCG TAGAAATGGA CGCTGCCCCC GGAGTGGACC TCACCAGGCT CCTCAATGAT 
ATGCGGGCGC AGTATGAAAC CATCGCTGAG CAGAATCGGA AGGACGCTGA AGCCTGGTTC 
ATTGAAAAGA GCGGGGAGCT CCGTAAGGAG ATTAGCACCA ACACCGAGCA GCTTCAGTCC 
AGCAAGAGCG AGGTCACCGA CCTGCGTCGC GCCTTTCAGA ACCTGGAGAT CGAGCTACAG 
TCCCAGCTCG CCATGAAGAA ATCCCTGGAG GACTCCTTGG CCGAAGCCGA GGGCGATTAC 
TGCGCGCAGC TGTCCCAGGT GCAGCAGCTC ATCAGCAACC TGGAGGCACA GCTGCTCCAG 
GTGCGCGCGG ACGCAGAGCG CCAGAACGTG GACCACCAGC GGCTGCTGAA TGTCAAGGCC 
CGCCTGGAGC TGGAGATTGA GACCTACCGC CGCCTGCTGG ACGGGGAGGC CCAAGGTGAT 
GGTTTGGAGG AAAGTTTATT TGTGACAGAC TCCAAATCAC AAGCACAGTC AACTGATTCC 
TCTAAAGACC CAACCAAAAC CCGAAAAATC AAGACAGTTG TGCAGGAGAT GGTGAATGGT 
GAGGTGGTCT CATCTCAAGT TCAGGAAATT GAAGAACTAA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000214.1
CDS	25..1509
Translation	MDLSNNTMSLSVRTPGLSRRLSSQSVIGRPRGMSASSVGSGYGGSAFGFGASCGGGFSAASMFGSSSGFGGGSGSSMAGGLGAGYGRALGGGSFGGLGMGFGGSPGGGSLGILSGNDGGLLSGSEKETMQNLNDRLASYLDKVRALEEANTELENKIREWYETRGTGTADASQSDYSKYYPLIEDLRNKIISASIGNAQLLLQIDNARLAAEDFRMKYENELALRQGVEADINGLRRVLDELTLTRTDLEMQIESLNEELAYMKKNHEDELQSFRVGGPGEVSVEMDAAPGVDLTRLLNDMRAQYETIAEQNRKDAEAWFIEKSGELRKEISTNTEQLQSSKSEVTDLRRAFQNLEIELQSQLAMKKSLEDSLAEAEGDYCAQLSQVQQLISNLEAQLLQVRADAERQNVDHQRLLNVKARLELEIETYRRLLDGEAQGDGLEESLFVTDSKSQAQSTDSSKDPTKTRKIKTVVQEMVNGEVVSSQVQEIEELM

Target ORF information:

RefSeq Version	NM_000223.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 12 (KRT12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000223.3

ORF Insert Sequence:

ATGGATCTCT CCAACAACAC CATGTCACTC TCAGTGCGCA CCCCCGGACT GTCCCGGCGG 
CTCTCCTCGC AGAGTGTGAT AGGCAGACCC AGGGGCATGT CTGCTTCCAG TGTTGGAAGT 
GGTTATGGGG GAAGTGCCTT TGGCTTTGGA GCCAGCTGTG GGGGAGGCTT TTCTGCTGCT 
TCCATGTTTG GTTCTAGTTC CGGCTTTGGG GGTGGCTCCG GAAGTTCCAT GGCAGGAGGA 
CTGGGTGCTG GTTATGGGAG AGCCCTGGGT GGAGGTAGCT TTGGAGGGCT GGGGATGGGA 
TTTGGGGGCA GCCCAGGAGG TGGCTCTCTA GGTATTCTCT CGGGCAATGA TGGAGGCCTT 
CTTTCTGGAT CAGAAAAAGA AACTATGCAA AATCTTAATG ATAGATTAGC TTCCTACCTG 
GATAAGGTGC GAGCTCTAGA AGAGGCTAAT ACTGAGCTAG AAAATAAAAT TCGAGAATGG 
TATGAAACAC GAGGAACTGG GACTGCAGAT GCTTCACAGA GCGATTACAG CAAATATTAT 
CCACTGATTG AAGACCTCAG GAATAAGATC ATTTCAGCCA GCATTGGAAA TGCCCAGCTC 
CTCTTGCAGA TTGACAATGC GAGACTAGCT GCTGAGGACT TCAGGATGAA GTATGAGAAT 
GAACTGGCCC TGCGCCAGGG CGTAGAGGCC GACATCAATG GCCTGCGCCG GGTGCTGGAC 
GAGCTGACCC TGACCAGGAC CGACCTGGAG ATGCAGATCG AGAGCCTGAA CGAGGAGCTG 
GCCTACATGA AGAAGAACCA CGAGGATGAG CTCCAAAGCT TCCGGGTGGG CGGCCCAGGC 
GAGGTCAGCG TAGAAATGGA CGCTGCCCCC GGAGTGGACC TCACCAGGCT CCTCAATGAT 
ATGCGGGCGC AGTATGAAAC CATCGCTGAG CAGAATCGGA AGGACGCTGA AGCCTGGTTC 
ATTGAAAAGA GCGGGGAGCT CCGTAAGGAG ATTAGCACCA ACACCGAGCA GCTTCAGTCC 
AGCAAGAGCG AGGTCACCGA CCTGCGTCGC GCCTTTCAGA ACCTGGAGAT CGAGCTACAG 
TCCCAGCTCG CCATGAAGAA ATCCCTGGAG GACTCCTTGG CCGAAGCCGA GGGCGATTAC 
TGCGCGCAGC TGTCCCAGGT GCAGCAGCTC ATCAGCAACC TGGAGGCACA GCTGCTCCAG 
GTGCGCGCGG ACGCAGAGCG CCAGAACGTG GACCACCAGC GGCTGCTGAA TGTCAAGGCC 
CGCCTGGAGC TGGAGATTGA GACCTACCGC CGCCTGCTGG ACGGGGAGGC CCAAGGTGAT 
GGTTTGGAGG AAAGTTTATT TGTGACAGAC TCCAAATCAC AAGCACAGTC AACTGATTCC 
TCTAAAGACC CAACCAAAAC CCGAAAAATC AAGACAGTTG TGCAGGAGAT GGTGAATGGT 
GAGGTGGTCT CATCTCAAGT TCAGGAAATT GAAGAACTAA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In vivo histology and p.L132V mutation in KRT12 gene in Japanese patients with Meesmann corneal dystrophy.
Japanese journal of ophthalmology63(1)46-55(2019 Jan)
Nishino T,Kobayashi A,Mori N,Masaki T,Yokogawa H,Fujiki K,Yanagawa A,Murakami A,Sugiyama K

Human aniridia limbal epithelial cells lack expression of keratins K3 and K12.
Experimental eye research167100-109(2018 02)
Latta L,Viestenz A,Stachon T,Colanesi S,Szentmáry N,Seitz B,Käsmann-Kellner B

Mutation analysis of TGFBI and KRT12 in a case of concomitant keratoconus and granular corneal dystrophy.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie255(9)1779-1786(2017 Sep)
Du X,Chen P,Sun D

PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific Genes.
Scientific reports620807(2016 Feb)
Sasamoto Y,Hayashi R,Park SJ,Saito-Adachi M,Suzuki Y,Kawasaki S,Quantock AJ,Nakai K,Tsujikawa M,Nishida K

siRNA silencing of the mutant keratin 12 allele in corneal limbal epithelial cells grown from patients with Meesmann's epithelial corneal dystrophy.
Investigative ophthalmology & visual science55(5)3352-60(2014 May)
Courtney DG,Atkinson SD,Allen EH,Moore JE,Walsh CP,Pedrioli DM,MacEwen CJ,Pellegrini G,Maurizi E,Serafini C,Fantacci M,Liao H,Irvine AD,McLean WH,Moore CB

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KRT12 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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