KDR cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KDR
Entrez Gene ID	3791
Full Name	kinase insert domain receptor
Synonyms	CD309,FLK1,VEGFR,VEGFR2
General protein information	Preferred Names kinase insert domain receptor Names vascular endothelial growth factor receptor 2 fetal liver kinase-1 kinase insert domain receptor (a type III receptor tyrosine kinase) protein-tyrosine kinase receptor Flk-1 soluble VEGFR2 tyrosine kinase growth factor receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q12
Summary	Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009].
Disorder MIM:	191306
Disorder Html:	Hemangioma, capillary infantile, somatic, 602089 (3); {Hemangioma, capillary infantile, susceptibility to}, 602089 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002253.2	NP_002244.1	vascular endothelial growth factor receptor 2 precursor
NM_002253.3	NP_002244.1	vascular endothelial growth factor receptor 2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Kdr	NP_034742.2
Homo sapiens (human)	KDR	NP_002244.1
Canis lupus familiaris (dog)	KDR	NP_001041489.1
Gallus gallus (chicken)	KDR	NP_001004368.1
Macaca mulatta (Rhesus monkey)	KDR	XP_001086814.2
Bos taurus (cattle)	KDR	NP_001103470.1
Danio rerio (zebrafish)	kdr	NP_001019824.2
Rattus norvegicus (Norway rat)	Kdr	NP_037194.1
Pan troglodytes (chimpanzee)	KDR	XP_517284.3
Xenopus tropicalis (tropical clawed frog)	kdr	XP_002934715.2

Gene Ontology
Bibliography

Related articles in PubMed

Suppression of migratory and metastatic pathways via blocking VEGFR1 and VEGFR2.
Sadremomtaz A, Kobarfard F, Mansouri K, Mirzanejad L, Asghari SM
Journal of receptor and signal transduction research38(5-6)432-441(2018 Oct - Dec)

Associations of
Vasconcelos VCA, Lourenço GJ, Brito ABC, Vasconcelos VL, Maldaun MVC, Tedeschi H, Marie SKN, Shinjo SMO, Lima CSP
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine41(9)1010428319872092(2019 Sep)

Vascular endothelial growth factor (VEGF) impairs the motility and immune function of human mature dendritic cells through the VEGF receptor 2-RhoA-cofilin1 pathway.
Long J, Hu Z, Xue H, Wang Y, Chen J, Tang F, Zhou J, Liu L, Qiu W, Zhang S, Ouyang Y, Ye Y, Xu G, Li L, Zeng Z
Cancer science110(8)2357-2367(2019 Aug)

miR‑497 suppresses malignant phenotype in non‑small cell lung cancer via targeting KDR.
Xia Y, Hu C, Lian L, Hui K, Wang L, Qiao Y, Liu L, Liang L, Jiang X
Oncology reports42(1)443-452(2019 Jul)

ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway.
Zhang Q, Lu S, Li T, Yu L, Zhang Y, Zeng H, Qian X, Bi J, Lin Y
Journal of experimental & clinical cancer research : CR38(1)173(2019 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KDR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KDR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27183	NM_002253.3 Latest version!	Homo sapiens kinase insert domain receptor (KDR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
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OHu27183	NM_002253.2	Homo sapiens kinase insert domain receptor (KDR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KDR ( NM_002253.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002244.1 Homo sapiens kinase insert domain receptor (KDR), mRNA.

Price & Availability↑

CloneID	OHu27183
Clone ID Related Accession (Same CDS sequence)	NM_002253.2 , NM_002253.3
Accession Version	NM_002253.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1513440000000
Organism	Homo sapiens(human)
Product	vascular endothelial growth factor receptor 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP280621.1, AF035121.1 and AC111194.4. This sequence is a reference standard in the RefSeqGene project. On Aug 5, 2008 this sequence version replaced NM_002253.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of the transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF035121.1, AB209901.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 19372376 ##RefSeq-Attributes-END##

ATGCAGAGCA AGGTGCTGCT GGCCGTCGCC CTGTGGCTCT GCGTGGAGAC CCGGGCCGCC 
TCTGTGGGTT TGCCTAGTGT TTCTCTTGAT CTGCCCAGGC TCAGCATACA AAAAGACATA 
CTTACAATTA AGGCTAATAC AACTCTTCAA ATTACTTGCA GGGGACAGAG GGACTTGGAC 
TGGCTTTGGC CCAATAATCA GAGTGGCAGT GAGCAAAGGG TGGAGGTGAC TGAGTGCAGC 
GATGGCCTCT TCTGTAAGAC ACTCACAATT CCAAAAGTGA TCGGAAATGA CACTGGAGCC 
TACAAGTGCT TCTACCGGGA AACTGACTTG GCCTCGGTCA TTTATGTCTA TGTTCAAGAT 
TACAGATCTC CATTTATTGC TTCTGTTAGT GACCAACATG GAGTCGTGTA CATTACTGAG 
AACAAAAACA AAACTGTGGT GATTCCATGT CTCGGGTCCA TTTCAAATCT CAACGTGTCA 
CTTTGTGCAA GATACCCAGA AAAGAGATTT GTTCCTGATG GTAACAGAAT TTCCTGGGAC 
AGCAAGAAGG GCTTTACTAT TCCCAGCTAC ATGATCAGCT ATGCTGGCAT GGTCTTCTGT 
GAAGCAAAAA TTAATGATGA AAGTTACCAG TCTATTATGT ACATAGTTGT CGTTGTAGGG 
TATAGGATTT ATGATGTGGT TCTGAGTCCG TCTCATGGAA TTGAACTATC TGTTGGAGAA 
AAGCTTGTCT TAAATTGTAC AGCAAGAACT GAACTAAATG TGGGGATTGA CTTCAACTGG 
GAATACCCTT CTTCGAAGCA TCAGCATAAG AAACTTGTAA ACCGAGACCT AAAAACCCAG 
TCTGGGAGTG AGATGAAGAA ATTTTTGAGC ACCTTAACTA TAGATGGTGT AACCCGGAGT 
GACCAAGGAT TGTACACCTG TGCAGCATCC AGTGGGCTGA TGACCAAGAA GAACAGCACA 
TTTGTCAGGG TCCATGAAAA ACCTTTTGTT GCTTTTGGAA GTGGCATGGA ATCTCTGGTG 
GAAGCCACGG TGGGGGAGCG TGTCAGAATC CCTGCGAAGT ACCTTGGTTA CCCACCCCCA 
GAAATAAAAT GGTATAAAAA TGGAATACCC CTTGAGTCCA ATCACACAAT TAAAGCGGGG 
CATGTACTGA CGATTATGGA AGTGAGTGAA AGAGACACAG GAAATTACAC TGTCATCCTT 
ACCAATCCCA TTTCAAAGGA GAAGCAGAGC CATGTGGTCT CTCTGGTTGT GTATGTCCCA 
CCCCAGATTG GTGAGAAATC TCTAATCTCT CCTGTGGATT CCTACCAGTA CGGCACCACT 
CAAACGCTGA CATGTACGGT CTATGCCATT CCTCCCCCGC ATCACATCCA CTGGTATTGG 
CAGTTGGAGG AAGAGTGCGC CAACGAGCCC AGCCAAGCTG TCTCAGTGAC AAACCCATAC 
CCTTGTGAAG AATGGAGAAG TGTGGAGGAC TTCCAGGGAG GAAATAAAAT TGAAGTTAAT 
AAAAATCAAT TTGCTCTAAT TGAAGGAAAA AACAAAACTG TAAGTACCCT TGTTATCCAA 
GCGGCAAATG TGTCAGCTTT GTACAAATGT GAAGCGGTCA ACAAAGTCGG GAGAGGAGAG 
AGGGTGATCT CCTTCCACGT GACCAGGGGT CCTGAAATTA CTTTGCAACC TGACATGCAG 
CCCACTGAGC AGGAGAGCGT GTCTTTGTGG TGCACTGCAG ACAGATCTAC GTTTGAGAAC 
CTCACATGGT ACAAGCTTGG CCCACAGCCT CTGCCAATCC ATGTGGGAGA GTTGCCCACA 
CCTGTTTGCA AGAACTTGGA TACTCTTTGG AAATTGAATG CCACCATGTT CTCTAATAGC 
ACAAATGACA TTTTGATCAT GGAGCTTAAG AATGCATCCT TGCAGGACCA AGGAGACTAT 
GTCTGCCTTG CTCAAGACAG GAAGACCAAG AAAAGACATT GCGTGGTCAG GCAGCTCACA 
GTCCTAGAGC GTGTGGCACC CACGATCACA GGAAACCTGG AGAATCAGAC GACAAGTATT 
GGGGAAAGCA TCGAAGTCTC ATGCACGGCA TCTGGGAATC CCCCTCCACA GATCATGTGG 
TTTAAAGATA ATGAGACCCT TGTAGAAGAC TCAGGCATTG TATTGAAGGA TGGGAACCGG 
AACCTCACTA TCCGCAGAGT GAGGAAGGAG GACGAAGGCC TCTACACCTG CCAGGCATGC 
AGTGTTCTTG GCTGTGCAAA AGTGGAGGCA TTTTTCATAA TAGAAGGTGC CCAGGAAAAG 
ACGAACTTGG AAATCATTAT TCTAGTAGGC ACGGCGGTGA TTGCCATGTT CTTCTGGCTA 
CTTCTTGTCA TCATCCTACG GACCGTTAAG CGGGCCAATG GAGGGGAACT GAAGACAGGC 
TACTTGTCCA TCGTCATGGA TCCAGATGAA CTCCCATTGG ATGAACATTG TGAACGACTG 
CCTTATGATG CCAGCAAATG GGAATTCCCC AGAGACCGGC TGAAGCTAGG TAAGCCTCTT 
GGCCGTGGTG CCTTTGGCCA AGTGATTGAA GCAGATGCCT TTGGAATTGA CAAGACAGCA 
ACTTGCAGGA CAGTAGCAGT CAAAATGTTG AAAGAAGGAG CAACACACAG TGAGCATCGA 
GCTCTCATGT CTGAACTCAA GATCCTCATT CATATTGGTC ACCATCTCAA TGTGGTCAAC 
CTTCTAGGTG CCTGTACCAA GCCAGGAGGG CCACTCATGG TGATTGTGGA ATTCTGCAAA 
TTTGGAAACC TGTCCACTTA CCTGAGGAGC AAGAGAAATG AATTTGTCCC CTACAAGACC 
AAAGGGGCAC GATTCCGTCA AGGGAAAGAC TACGTTGGAG CAATCCCTGT GGATCTGAAA 
CGGCGCTTGG ACAGCATCAC CAGTAGCCAG AGCTCAGCCA GCTCTGGATT TGTGGAGGAG 
AAGTCCCTCA GTGATGTAGA AGAAGAGGAA GCTCCTGAAG ATCTGTATAA GGACTTCCTG 
ACCTTGGAGC ATCTCATCTG TTACAGCTTC CAAGTGGCTA AGGGCATGGA GTTCTTGGCA 
TCGCGAAAGT GTATCCACAG GGACCTGGCG GCACGAAATA TCCTCTTATC GGAGAAGAAC 
GTGGTTAAAA TCTGTGACTT TGGCTTGGCC CGGGATATTT ATAAAGATCC AGATTATGTC 
AGAAAAGGAG ATGCTCGCCT CCCTTTGAAA TGGATGGCCC CAGAAACAAT TTTTGACAGA 
GTGTACACAA TCCAGAGTGA CGTCTGGTCT TTTGGTGTTT TGCTGTGGGA AATATTTTCC 
TTAGGTGCTT CTCCATATCC TGGGGTAAAG ATTGATGAAG AATTTTGTAG GCGATTGAAA 
GAAGGAACTA GAATGAGGGC CCCTGATTAT ACTACACCAG AAATGTACCA GACCATGCTG 
GACTGCTGGC ACGGGGAGCC CAGTCAGAGA CCCACGTTTT CAGAGTTGGT GGAACATTTG 
GGAAATCTCT TGCAAGCTAA TGCTCAGCAG GATGGCAAAG ACTACATTGT TCTTCCGATA 
TCAGAGACTT TGAGCATGGA AGAGGATTCT GGACTCTCTC TGCCTACCTC ACCTGTTTCC 
TGTATGGAGG AGGAGGAAGT ATGTGACCCC AAATTCCATT ATGACAACAC AGCAGGAATC 
AGTCAGTATC TGCAGAACAG TAAGCGAAAG AGCCGGCCTG TGAGTGTAAA AACATTTGAA 
GATATCCCGT TAGAAGAACC AGAAGTAAAA GTAATCCCAG ATGACAACCA GACGGACAGT 
GGTATGGTTC TTGCCTCAGA AGAGCTGAAA ACTTTGGAAG ACAGAACCAA ATTATCTCCA 
TCTTTTGGTG GAATGGTGCC CAGCAAAAGC AGGGAGTCTG TGGCATCTGA AGGCTCAAAC 
CAGACAAGCG GCTACCAGTC CGGATATCAC TCCGATGACA CAGACACCAC CGTGTACTCC 
AGTGAGGAAG CAGAACTTTT AAAGCTGATA GAGATTGGAG TGCAAACCGG TAGCACAGCC 
CAGATTCTCC AGCCTGACTC GGGGACCACA CTGAGCTCTC CTCCTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002244.1
CDS	303..4373
Translation	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV

Target ORF information:

RefSeq Version	NM_002253.2
Organism	Homo sapiens(human)
Definition	Homo sapiens kinase insert domain receptor (KDR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002253.2

ORF Insert Sequence:

ATGCAGAGCA AGGTGCTGCT GGCCGTCGCC CTGTGGCTCT GCGTGGAGAC CCGGGCCGCC 
TCTGTGGGTT TGCCTAGTGT TTCTCTTGAT CTGCCCAGGC TCAGCATACA AAAAGACATA 
CTTACAATTA AGGCTAATAC AACTCTTCAA ATTACTTGCA GGGGACAGAG GGACTTGGAC 
TGGCTTTGGC CCAATAATCA GAGTGGCAGT GAGCAAAGGG TGGAGGTGAC TGAGTGCAGC 
GATGGCCTCT TCTGTAAGAC ACTCACAATT CCAAAAGTGA TCGGAAATGA CACTGGAGCC 
TACAAGTGCT TCTACCGGGA AACTGACTTG GCCTCGGTCA TTTATGTCTA TGTTCAAGAT 
TACAGATCTC CATTTATTGC TTCTGTTAGT GACCAACATG GAGTCGTGTA CATTACTGAG 
AACAAAAACA AAACTGTGGT GATTCCATGT CTCGGGTCCA TTTCAAATCT CAACGTGTCA 
CTTTGTGCAA GATACCCAGA AAAGAGATTT GTTCCTGATG GTAACAGAAT TTCCTGGGAC 
AGCAAGAAGG GCTTTACTAT TCCCAGCTAC ATGATCAGCT ATGCTGGCAT GGTCTTCTGT 
GAAGCAAAAA TTAATGATGA AAGTTACCAG TCTATTATGT ACATAGTTGT CGTTGTAGGG 
TATAGGATTT ATGATGTGGT TCTGAGTCCG TCTCATGGAA TTGAACTATC TGTTGGAGAA 
AAGCTTGTCT TAAATTGTAC AGCAAGAACT GAACTAAATG TGGGGATTGA CTTCAACTGG 
GAATACCCTT CTTCGAAGCA TCAGCATAAG AAACTTGTAA ACCGAGACCT AAAAACCCAG 
TCTGGGAGTG AGATGAAGAA ATTTTTGAGC ACCTTAACTA TAGATGGTGT AACCCGGAGT 
GACCAAGGAT TGTACACCTG TGCAGCATCC AGTGGGCTGA TGACCAAGAA GAACAGCACA 
TTTGTCAGGG TCCATGAAAA ACCTTTTGTT GCTTTTGGAA GTGGCATGGA ATCTCTGGTG 
GAAGCCACGG TGGGGGAGCG TGTCAGAATC CCTGCGAAGT ACCTTGGTTA CCCACCCCCA 
GAAATAAAAT GGTATAAAAA TGGAATACCC CTTGAGTCCA ATCACACAAT TAAAGCGGGG 
CATGTACTGA CGATTATGGA AGTGAGTGAA AGAGACACAG GAAATTACAC TGTCATCCTT 
ACCAATCCCA TTTCAAAGGA GAAGCAGAGC CATGTGGTCT CTCTGGTTGT GTATGTCCCA 
CCCCAGATTG GTGAGAAATC TCTAATCTCT CCTGTGGATT CCTACCAGTA CGGCACCACT 
CAAACGCTGA CATGTACGGT CTATGCCATT CCTCCCCCGC ATCACATCCA CTGGTATTGG 
CAGTTGGAGG AAGAGTGCGC CAACGAGCCC AGCCAAGCTG TCTCAGTGAC AAACCCATAC 
CCTTGTGAAG AATGGAGAAG TGTGGAGGAC TTCCAGGGAG GAAATAAAAT TGAAGTTAAT 
AAAAATCAAT TTGCTCTAAT TGAAGGAAAA AACAAAACTG TAAGTACCCT TGTTATCCAA 
GCGGCAAATG TGTCAGCTTT GTACAAATGT GAAGCGGTCA ACAAAGTCGG GAGAGGAGAG 
AGGGTGATCT CCTTCCACGT GACCAGGGGT CCTGAAATTA CTTTGCAACC TGACATGCAG 
CCCACTGAGC AGGAGAGCGT GTCTTTGTGG TGCACTGCAG ACAGATCTAC GTTTGAGAAC 
CTCACATGGT ACAAGCTTGG CCCACAGCCT CTGCCAATCC ATGTGGGAGA GTTGCCCACA 
CCTGTTTGCA AGAACTTGGA TACTCTTTGG AAATTGAATG CCACCATGTT CTCTAATAGC 
ACAAATGACA TTTTGATCAT GGAGCTTAAG AATGCATCCT TGCAGGACCA AGGAGACTAT 
GTCTGCCTTG CTCAAGACAG GAAGACCAAG AAAAGACATT GCGTGGTCAG GCAGCTCACA 
GTCCTAGAGC GTGTGGCACC CACGATCACA GGAAACCTGG AGAATCAGAC GACAAGTATT 
GGGGAAAGCA TCGAAGTCTC ATGCACGGCA TCTGGGAATC CCCCTCCACA GATCATGTGG 
TTTAAAGATA ATGAGACCCT TGTAGAAGAC TCAGGCATTG TATTGAAGGA TGGGAACCGG 
AACCTCACTA TCCGCAGAGT GAGGAAGGAG GACGAAGGCC TCTACACCTG CCAGGCATGC 
AGTGTTCTTG GCTGTGCAAA AGTGGAGGCA TTTTTCATAA TAGAAGGTGC CCAGGAAAAG 
ACGAACTTGG AAATCATTAT TCTAGTAGGC ACGGCGGTGA TTGCCATGTT CTTCTGGCTA 
CTTCTTGTCA TCATCCTACG GACCGTTAAG CGGGCCAATG GAGGGGAACT GAAGACAGGC 
TACTTGTCCA TCGTCATGGA TCCAGATGAA CTCCCATTGG ATGAACATTG TGAACGACTG 
CCTTATGATG CCAGCAAATG GGAATTCCCC AGAGACCGGC TGAAGCTAGG TAAGCCTCTT 
GGCCGTGGTG CCTTTGGCCA AGTGATTGAA GCAGATGCCT TTGGAATTGA CAAGACAGCA 
ACTTGCAGGA CAGTAGCAGT CAAAATGTTG AAAGAAGGAG CAACACACAG TGAGCATCGA 
GCTCTCATGT CTGAACTCAA GATCCTCATT CATATTGGTC ACCATCTCAA TGTGGTCAAC 
CTTCTAGGTG CCTGTACCAA GCCAGGAGGG CCACTCATGG TGATTGTGGA ATTCTGCAAA 
TTTGGAAACC TGTCCACTTA CCTGAGGAGC AAGAGAAATG AATTTGTCCC CTACAAGACC 
AAAGGGGCAC GATTCCGTCA AGGGAAAGAC TACGTTGGAG CAATCCCTGT GGATCTGAAA 
CGGCGCTTGG ACAGCATCAC CAGTAGCCAG AGCTCAGCCA GCTCTGGATT TGTGGAGGAG 
AAGTCCCTCA GTGATGTAGA AGAAGAGGAA GCTCCTGAAG ATCTGTATAA GGACTTCCTG 
ACCTTGGAGC ATCTCATCTG TTACAGCTTC CAAGTGGCTA AGGGCATGGA GTTCTTGGCA 
TCGCGAAAGT GTATCCACAG GGACCTGGCG GCACGAAATA TCCTCTTATC GGAGAAGAAC 
GTGGTTAAAA TCTGTGACTT TGGCTTGGCC CGGGATATTT ATAAAGATCC AGATTATGTC 
AGAAAAGGAG ATGCTCGCCT CCCTTTGAAA TGGATGGCCC CAGAAACAAT TTTTGACAGA 
GTGTACACAA TCCAGAGTGA CGTCTGGTCT TTTGGTGTTT TGCTGTGGGA AATATTTTCC 
TTAGGTGCTT CTCCATATCC TGGGGTAAAG ATTGATGAAG AATTTTGTAG GCGATTGAAA 
GAAGGAACTA GAATGAGGGC CCCTGATTAT ACTACACCAG AAATGTACCA GACCATGCTG 
GACTGCTGGC ACGGGGAGCC CAGTCAGAGA CCCACGTTTT CAGAGTTGGT GGAACATTTG 
GGAAATCTCT TGCAAGCTAA TGCTCAGCAG GATGGCAAAG ACTACATTGT TCTTCCGATA 
TCAGAGACTT TGAGCATGGA AGAGGATTCT GGACTCTCTC TGCCTACCTC ACCTGTTTCC 
TGTATGGAGG AGGAGGAAGT ATGTGACCCC AAATTCCATT ATGACAACAC AGCAGGAATC 
AGTCAGTATC TGCAGAACAG TAAGCGAAAG AGCCGGCCTG TGAGTGTAAA AACATTTGAA 
GATATCCCGT TAGAAGAACC AGAAGTAAAA GTAATCCCAG ATGACAACCA GACGGACAGT 
GGTATGGTTC TTGCCTCAGA AGAGCTGAAA ACTTTGGAAG ACAGAACCAA ATTATCTCCA 
TCTTTTGGTG GAATGGTGCC CAGCAAAAGC AGGGAGTCTG TGGCATCTGA AGGCTCAAAC 
CAGACAAGCG GCTACCAGTC CGGATATCAC TCCGATGACA CAGACACCAC CGTGTACTCC 
AGTGAGGAAG CAGAACTTTT AAAGCTGATA GAGATTGGAG TGCAAACCGG TAGCACAGCC 
CAGATTCTCC AGCCTGACTC GGGGACCACA CTGAGCTCTC CTCCTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KDR ( NM_002253.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002244.1 Homo sapiens kinase insert domain receptor (KDR), mRNA.

Price & Availability↑

CloneID	OHu27183
Clone ID Related Accession (Same CDS sequence)	NM_002253.2 , NM_002253.3
Accession Version	NM_002253.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577721600000
Organism	Homo sapiens(human)
Product	vascular endothelial growth factor receptor 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP280621.1, AF035121.1, AC111194.4 and BM978033.1. This sequence is a reference standard in the RefSeqGene project. On Jan 23, 2018 this sequence version replaced NM_002253.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of the transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF035121.1, AB209901.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript regulatory uORF :: PMID: 19372376 ##RefSeq-Attributes-END##

ATGCAGAGCA AGGTGCTGCT GGCCGTCGCC CTGTGGCTCT GCGTGGAGAC CCGGGCCGCC 
TCTGTGGGTT TGCCTAGTGT TTCTCTTGAT CTGCCCAGGC TCAGCATACA AAAAGACATA 
CTTACAATTA AGGCTAATAC AACTCTTCAA ATTACTTGCA GGGGACAGAG GGACTTGGAC 
TGGCTTTGGC CCAATAATCA GAGTGGCAGT GAGCAAAGGG TGGAGGTGAC TGAGTGCAGC 
GATGGCCTCT TCTGTAAGAC ACTCACAATT CCAAAAGTGA TCGGAAATGA CACTGGAGCC 
TACAAGTGCT TCTACCGGGA AACTGACTTG GCCTCGGTCA TTTATGTCTA TGTTCAAGAT 
TACAGATCTC CATTTATTGC TTCTGTTAGT GACCAACATG GAGTCGTGTA CATTACTGAG 
AACAAAAACA AAACTGTGGT GATTCCATGT CTCGGGTCCA TTTCAAATCT CAACGTGTCA 
CTTTGTGCAA GATACCCAGA AAAGAGATTT GTTCCTGATG GTAACAGAAT TTCCTGGGAC 
AGCAAGAAGG GCTTTACTAT TCCCAGCTAC ATGATCAGCT ATGCTGGCAT GGTCTTCTGT 
GAAGCAAAAA TTAATGATGA AAGTTACCAG TCTATTATGT ACATAGTTGT CGTTGTAGGG 
TATAGGATTT ATGATGTGGT TCTGAGTCCG TCTCATGGAA TTGAACTATC TGTTGGAGAA 
AAGCTTGTCT TAAATTGTAC AGCAAGAACT GAACTAAATG TGGGGATTGA CTTCAACTGG 
GAATACCCTT CTTCGAAGCA TCAGCATAAG AAACTTGTAA ACCGAGACCT AAAAACCCAG 
TCTGGGAGTG AGATGAAGAA ATTTTTGAGC ACCTTAACTA TAGATGGTGT AACCCGGAGT 
GACCAAGGAT TGTACACCTG TGCAGCATCC AGTGGGCTGA TGACCAAGAA GAACAGCACA 
TTTGTCAGGG TCCATGAAAA ACCTTTTGTT GCTTTTGGAA GTGGCATGGA ATCTCTGGTG 
GAAGCCACGG TGGGGGAGCG TGTCAGAATC CCTGCGAAGT ACCTTGGTTA CCCACCCCCA 
GAAATAAAAT GGTATAAAAA TGGAATACCC CTTGAGTCCA ATCACACAAT TAAAGCGGGG 
CATGTACTGA CGATTATGGA AGTGAGTGAA AGAGACACAG GAAATTACAC TGTCATCCTT 
ACCAATCCCA TTTCAAAGGA GAAGCAGAGC CATGTGGTCT CTCTGGTTGT GTATGTCCCA 
CCCCAGATTG GTGAGAAATC TCTAATCTCT CCTGTGGATT CCTACCAGTA CGGCACCACT 
CAAACGCTGA CATGTACGGT CTATGCCATT CCTCCCCCGC ATCACATCCA CTGGTATTGG 
CAGTTGGAGG AAGAGTGCGC CAACGAGCCC AGCCAAGCTG TCTCAGTGAC AAACCCATAC 
CCTTGTGAAG AATGGAGAAG TGTGGAGGAC TTCCAGGGAG GAAATAAAAT TGAAGTTAAT 
AAAAATCAAT TTGCTCTAAT TGAAGGAAAA AACAAAACTG TAAGTACCCT TGTTATCCAA 
GCGGCAAATG TGTCAGCTTT GTACAAATGT GAAGCGGTCA ACAAAGTCGG GAGAGGAGAG 
AGGGTGATCT CCTTCCACGT GACCAGGGGT CCTGAAATTA CTTTGCAACC TGACATGCAG 
CCCACTGAGC AGGAGAGCGT GTCTTTGTGG TGCACTGCAG ACAGATCTAC GTTTGAGAAC 
CTCACATGGT ACAAGCTTGG CCCACAGCCT CTGCCAATCC ATGTGGGAGA GTTGCCCACA 
CCTGTTTGCA AGAACTTGGA TACTCTTTGG AAATTGAATG CCACCATGTT CTCTAATAGC 
ACAAATGACA TTTTGATCAT GGAGCTTAAG AATGCATCCT TGCAGGACCA AGGAGACTAT 
GTCTGCCTTG CTCAAGACAG GAAGACCAAG AAAAGACATT GCGTGGTCAG GCAGCTCACA 
GTCCTAGAGC GTGTGGCACC CACGATCACA GGAAACCTGG AGAATCAGAC GACAAGTATT 
GGGGAAAGCA TCGAAGTCTC ATGCACGGCA TCTGGGAATC CCCCTCCACA GATCATGTGG 
TTTAAAGATA ATGAGACCCT TGTAGAAGAC TCAGGCATTG TATTGAAGGA TGGGAACCGG 
AACCTCACTA TCCGCAGAGT GAGGAAGGAG GACGAAGGCC TCTACACCTG CCAGGCATGC 
AGTGTTCTTG GCTGTGCAAA AGTGGAGGCA TTTTTCATAA TAGAAGGTGC CCAGGAAAAG 
ACGAACTTGG AAATCATTAT TCTAGTAGGC ACGGCGGTGA TTGCCATGTT CTTCTGGCTA 
CTTCTTGTCA TCATCCTACG GACCGTTAAG CGGGCCAATG GAGGGGAACT GAAGACAGGC 
TACTTGTCCA TCGTCATGGA TCCAGATGAA CTCCCATTGG ATGAACATTG TGAACGACTG 
CCTTATGATG CCAGCAAATG GGAATTCCCC AGAGACCGGC TGAAGCTAGG TAAGCCTCTT 
GGCCGTGGTG CCTTTGGCCA AGTGATTGAA GCAGATGCCT TTGGAATTGA CAAGACAGCA 
ACTTGCAGGA CAGTAGCAGT CAAAATGTTG AAAGAAGGAG CAACACACAG TGAGCATCGA 
GCTCTCATGT CTGAACTCAA GATCCTCATT CATATTGGTC ACCATCTCAA TGTGGTCAAC 
CTTCTAGGTG CCTGTACCAA GCCAGGAGGG CCACTCATGG TGATTGTGGA ATTCTGCAAA 
TTTGGAAACC TGTCCACTTA CCTGAGGAGC AAGAGAAATG AATTTGTCCC CTACAAGACC 
AAAGGGGCAC GATTCCGTCA AGGGAAAGAC TACGTTGGAG CAATCCCTGT GGATCTGAAA 
CGGCGCTTGG ACAGCATCAC CAGTAGCCAG AGCTCAGCCA GCTCTGGATT TGTGGAGGAG 
AAGTCCCTCA GTGATGTAGA AGAAGAGGAA GCTCCTGAAG ATCTGTATAA GGACTTCCTG 
ACCTTGGAGC ATCTCATCTG TTACAGCTTC CAAGTGGCTA AGGGCATGGA GTTCTTGGCA 
TCGCGAAAGT GTATCCACAG GGACCTGGCG GCACGAAATA TCCTCTTATC GGAGAAGAAC 
GTGGTTAAAA TCTGTGACTT TGGCTTGGCC CGGGATATTT ATAAAGATCC AGATTATGTC 
AGAAAAGGAG ATGCTCGCCT CCCTTTGAAA TGGATGGCCC CAGAAACAAT TTTTGACAGA 
GTGTACACAA TCCAGAGTGA CGTCTGGTCT TTTGGTGTTT TGCTGTGGGA AATATTTTCC 
TTAGGTGCTT CTCCATATCC TGGGGTAAAG ATTGATGAAG AATTTTGTAG GCGATTGAAA 
GAAGGAACTA GAATGAGGGC CCCTGATTAT ACTACACCAG AAATGTACCA GACCATGCTG 
GACTGCTGGC ACGGGGAGCC CAGTCAGAGA CCCACGTTTT CAGAGTTGGT GGAACATTTG 
GGAAATCTCT TGCAAGCTAA TGCTCAGCAG GATGGCAAAG ACTACATTGT TCTTCCGATA 
TCAGAGACTT TGAGCATGGA AGAGGATTCT GGACTCTCTC TGCCTACCTC ACCTGTTTCC 
TGTATGGAGG AGGAGGAAGT ATGTGACCCC AAATTCCATT ATGACAACAC AGCAGGAATC 
AGTCAGTATC TGCAGAACAG TAAGCGAAAG AGCCGGCCTG TGAGTGTAAA AACATTTGAA 
GATATCCCGT TAGAAGAACC AGAAGTAAAA GTAATCCCAG ATGACAACCA GACGGACAGT 
GGTATGGTTC TTGCCTCAGA AGAGCTGAAA ACTTTGGAAG ACAGAACCAA ATTATCTCCA 
TCTTTTGGTG GAATGGTGCC CAGCAAAAGC AGGGAGTCTG TGGCATCTGA AGGCTCAAAC 
CAGACAAGCG GCTACCAGTC CGGATATCAC TCCGATGACA CAGACACCAC CGTGTACTCC 
AGTGAGGAAG CAGAACTTTT AAAGCTGATA GAGATTGGAG TGCAAACCGG TAGCACAGCC 
CAGATTCTCC AGCCTGACTC GGGGACCACA CTGAGCTCTC CTCCTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002244.1
CDS	303..4373
Translation	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV

Target ORF information:

RefSeq Version	NM_002253.3
Organism	Homo sapiens(human)
Definition	Homo sapiens kinase insert domain receptor (KDR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002253.3

ORF Insert Sequence:

ATGCAGAGCA AGGTGCTGCT GGCCGTCGCC CTGTGGCTCT GCGTGGAGAC CCGGGCCGCC 
TCTGTGGGTT TGCCTAGTGT TTCTCTTGAT CTGCCCAGGC TCAGCATACA AAAAGACATA 
CTTACAATTA AGGCTAATAC AACTCTTCAA ATTACTTGCA GGGGACAGAG GGACTTGGAC 
TGGCTTTGGC CCAATAATCA GAGTGGCAGT GAGCAAAGGG TGGAGGTGAC TGAGTGCAGC 
GATGGCCTCT TCTGTAAGAC ACTCACAATT CCAAAAGTGA TCGGAAATGA CACTGGAGCC 
TACAAGTGCT TCTACCGGGA AACTGACTTG GCCTCGGTCA TTTATGTCTA TGTTCAAGAT 
TACAGATCTC CATTTATTGC TTCTGTTAGT GACCAACATG GAGTCGTGTA CATTACTGAG 
AACAAAAACA AAACTGTGGT GATTCCATGT CTCGGGTCCA TTTCAAATCT CAACGTGTCA 
CTTTGTGCAA GATACCCAGA AAAGAGATTT GTTCCTGATG GTAACAGAAT TTCCTGGGAC 
AGCAAGAAGG GCTTTACTAT TCCCAGCTAC ATGATCAGCT ATGCTGGCAT GGTCTTCTGT 
GAAGCAAAAA TTAATGATGA AAGTTACCAG TCTATTATGT ACATAGTTGT CGTTGTAGGG 
TATAGGATTT ATGATGTGGT TCTGAGTCCG TCTCATGGAA TTGAACTATC TGTTGGAGAA 
AAGCTTGTCT TAAATTGTAC AGCAAGAACT GAACTAAATG TGGGGATTGA CTTCAACTGG 
GAATACCCTT CTTCGAAGCA TCAGCATAAG AAACTTGTAA ACCGAGACCT AAAAACCCAG 
TCTGGGAGTG AGATGAAGAA ATTTTTGAGC ACCTTAACTA TAGATGGTGT AACCCGGAGT 
GACCAAGGAT TGTACACCTG TGCAGCATCC AGTGGGCTGA TGACCAAGAA GAACAGCACA 
TTTGTCAGGG TCCATGAAAA ACCTTTTGTT GCTTTTGGAA GTGGCATGGA ATCTCTGGTG 
GAAGCCACGG TGGGGGAGCG TGTCAGAATC CCTGCGAAGT ACCTTGGTTA CCCACCCCCA 
GAAATAAAAT GGTATAAAAA TGGAATACCC CTTGAGTCCA ATCACACAAT TAAAGCGGGG 
CATGTACTGA CGATTATGGA AGTGAGTGAA AGAGACACAG GAAATTACAC TGTCATCCTT 
ACCAATCCCA TTTCAAAGGA GAAGCAGAGC CATGTGGTCT CTCTGGTTGT GTATGTCCCA 
CCCCAGATTG GTGAGAAATC TCTAATCTCT CCTGTGGATT CCTACCAGTA CGGCACCACT 
CAAACGCTGA CATGTACGGT CTATGCCATT CCTCCCCCGC ATCACATCCA CTGGTATTGG 
CAGTTGGAGG AAGAGTGCGC CAACGAGCCC AGCCAAGCTG TCTCAGTGAC AAACCCATAC 
CCTTGTGAAG AATGGAGAAG TGTGGAGGAC TTCCAGGGAG GAAATAAAAT TGAAGTTAAT 
AAAAATCAAT TTGCTCTAAT TGAAGGAAAA AACAAAACTG TAAGTACCCT TGTTATCCAA 
GCGGCAAATG TGTCAGCTTT GTACAAATGT GAAGCGGTCA ACAAAGTCGG GAGAGGAGAG 
AGGGTGATCT CCTTCCACGT GACCAGGGGT CCTGAAATTA CTTTGCAACC TGACATGCAG 
CCCACTGAGC AGGAGAGCGT GTCTTTGTGG TGCACTGCAG ACAGATCTAC GTTTGAGAAC 
CTCACATGGT ACAAGCTTGG CCCACAGCCT CTGCCAATCC ATGTGGGAGA GTTGCCCACA 
CCTGTTTGCA AGAACTTGGA TACTCTTTGG AAATTGAATG CCACCATGTT CTCTAATAGC 
ACAAATGACA TTTTGATCAT GGAGCTTAAG AATGCATCCT TGCAGGACCA AGGAGACTAT 
GTCTGCCTTG CTCAAGACAG GAAGACCAAG AAAAGACATT GCGTGGTCAG GCAGCTCACA 
GTCCTAGAGC GTGTGGCACC CACGATCACA GGAAACCTGG AGAATCAGAC GACAAGTATT 
GGGGAAAGCA TCGAAGTCTC ATGCACGGCA TCTGGGAATC CCCCTCCACA GATCATGTGG 
TTTAAAGATA ATGAGACCCT TGTAGAAGAC TCAGGCATTG TATTGAAGGA TGGGAACCGG 
AACCTCACTA TCCGCAGAGT GAGGAAGGAG GACGAAGGCC TCTACACCTG CCAGGCATGC 
AGTGTTCTTG GCTGTGCAAA AGTGGAGGCA TTTTTCATAA TAGAAGGTGC CCAGGAAAAG 
ACGAACTTGG AAATCATTAT TCTAGTAGGC ACGGCGGTGA TTGCCATGTT CTTCTGGCTA 
CTTCTTGTCA TCATCCTACG GACCGTTAAG CGGGCCAATG GAGGGGAACT GAAGACAGGC 
TACTTGTCCA TCGTCATGGA TCCAGATGAA CTCCCATTGG ATGAACATTG TGAACGACTG 
CCTTATGATG CCAGCAAATG GGAATTCCCC AGAGACCGGC TGAAGCTAGG TAAGCCTCTT 
GGCCGTGGTG CCTTTGGCCA AGTGATTGAA GCAGATGCCT TTGGAATTGA CAAGACAGCA 
ACTTGCAGGA CAGTAGCAGT CAAAATGTTG AAAGAAGGAG CAACACACAG TGAGCATCGA 
GCTCTCATGT CTGAACTCAA GATCCTCATT CATATTGGTC ACCATCTCAA TGTGGTCAAC 
CTTCTAGGTG CCTGTACCAA GCCAGGAGGG CCACTCATGG TGATTGTGGA ATTCTGCAAA 
TTTGGAAACC TGTCCACTTA CCTGAGGAGC AAGAGAAATG AATTTGTCCC CTACAAGACC 
AAAGGGGCAC GATTCCGTCA AGGGAAAGAC TACGTTGGAG CAATCCCTGT GGATCTGAAA 
CGGCGCTTGG ACAGCATCAC CAGTAGCCAG AGCTCAGCCA GCTCTGGATT TGTGGAGGAG 
AAGTCCCTCA GTGATGTAGA AGAAGAGGAA GCTCCTGAAG ATCTGTATAA GGACTTCCTG 
ACCTTGGAGC ATCTCATCTG TTACAGCTTC CAAGTGGCTA AGGGCATGGA GTTCTTGGCA 
TCGCGAAAGT GTATCCACAG GGACCTGGCG GCACGAAATA TCCTCTTATC GGAGAAGAAC 
GTGGTTAAAA TCTGTGACTT TGGCTTGGCC CGGGATATTT ATAAAGATCC AGATTATGTC 
AGAAAAGGAG ATGCTCGCCT CCCTTTGAAA TGGATGGCCC CAGAAACAAT TTTTGACAGA 
GTGTACACAA TCCAGAGTGA CGTCTGGTCT TTTGGTGTTT TGCTGTGGGA AATATTTTCC 
TTAGGTGCTT CTCCATATCC TGGGGTAAAG ATTGATGAAG AATTTTGTAG GCGATTGAAA 
GAAGGAACTA GAATGAGGGC CCCTGATTAT ACTACACCAG AAATGTACCA GACCATGCTG 
GACTGCTGGC ACGGGGAGCC CAGTCAGAGA CCCACGTTTT CAGAGTTGGT GGAACATTTG 
GGAAATCTCT TGCAAGCTAA TGCTCAGCAG GATGGCAAAG ACTACATTGT TCTTCCGATA 
TCAGAGACTT TGAGCATGGA AGAGGATTCT GGACTCTCTC TGCCTACCTC ACCTGTTTCC 
TGTATGGAGG AGGAGGAAGT ATGTGACCCC AAATTCCATT ATGACAACAC AGCAGGAATC 
AGTCAGTATC TGCAGAACAG TAAGCGAAAG AGCCGGCCTG TGAGTGTAAA AACATTTGAA 
GATATCCCGT TAGAAGAACC AGAAGTAAAA GTAATCCCAG ATGACAACCA GACGGACAGT 
GGTATGGTTC TTGCCTCAGA AGAGCTGAAA ACTTTGGAAG ACAGAACCAA ATTATCTCCA 
TCTTTTGGTG GAATGGTGCC CAGCAAAAGC AGGGAGTCTG TGGCATCTGA AGGCTCAAAC 
CAGACAAGCG GCTACCAGTC CGGATATCAC TCCGATGACA CAGACACCAC CGTGTACTCC 
AGTGAGGAAG CAGAACTTTT AAAGCTGATA GAGATTGGAG TGCAAACCGG TAGCACAGCC 
CAGATTCTCC AGCCTGACTC GGGGACCACA CTGAGCTCTC CTCCTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppression of migratory and metastatic pathways via blocking VEGFR1 and VEGFR2.
Journal of receptor and signal transduction research38(5-6)432-441(2018 Oct - Dec)
Sadremomtaz A,Kobarfard F,Mansouri K,Mirzanejad L,Asghari SM

Associations of
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine41(9)1010428319872092(2019 Sep)
Vasconcelos VCA,Lourenço GJ,Brito ABC,Vasconcelos VL,Maldaun MVC,Tedeschi H,Marie SKN,Shinjo SMO,Lima CSP

Vascular endothelial growth factor (VEGF) impairs the motility and immune function of human mature dendritic cells through the VEGF receptor 2-RhoA-cofilin1 pathway.
Cancer science110(8)2357-2367(2019 Aug)
Long J,Hu Z,Xue H,Wang Y,Chen J,Tang F,Zhou J,Liu L,Qiu W,Zhang S,Ouyang Y,Ye Y,Xu G,Li L,Zeng Z

miR‑497 suppresses malignant phenotype in non‑small cell lung cancer via targeting KDR.
Oncology reports42(1)443-452(2019 Jul)
Xia Y,Hu C,Lian L,Hui K,Wang L,Qiao Y,Liu L,Liang L,Jiang X

ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway.
Journal of experimental & clinical cancer research : CR38(1)173(2019 Apr)
Zhang Q,Lu S,Li T,Yu L,Zhang Y,Zeng H,Qian X,Bi J,Lin Y

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KDR cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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