IGFBP5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IGFBP5
Entrez Gene ID	3488
Full Name	insulin like growth factor binding protein 5
Synonyms	IBP5
General protein information	Preferred Names insulin like growth factor binding protein 5 Names insulin-like growth factor-binding protein 5 IBP-5 IGF-binding protein 5 IGFBP-5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q35
Disorder MIM:	146734

mRNA and Protein(s)

mRNA	Protein	Name
NM_000599.4	NP_000590.1	insulin-like growth factor-binding protein 5 precursor
NM_000599.3	NP_000590.1	insulin-like growth factor-binding protein 5 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IGFBP5	NP_001098797.1
Mus musculus (house mouse)	Igfbp5	NP_034648.2
Xenopus tropicalis (tropical clawed frog)	igfbp5	NP_001016042.1
Canis lupus familiaris (dog)	IGFBP5	XP_852885.1
Gallus gallus (chicken)	IGFBP5	XP_422069.3
Macaca mulatta (Rhesus monkey)	IGFBP5	XP_001087664.1
Danio rerio (zebrafish)	igfbp5b	NP_001092224.1
Homo sapiens (human)	IGFBP5	NP_000590.1
Pan troglodytes (chimpanzee)	IGFBP5	XP_003309513.1
Rattus norvegicus (Norway rat)	Igfbp5	NP_036949.1
Danio rerio (zebrafish)	igfbp5a	NP_001119935.1

Gene Ontology
Bibliography

Related articles in PubMed

Identifying the key genes and microRNAs in colorectal cancer liver metastasis by bioinformatics analysis and in vitro experiments.
Zhang T, Guo J, Gu J, Wang Z, Wang G, Li H, Wang J
Oncology reports41(1)279-291(2019 Jan)

Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects.
Xu S, Xu Y, Yin M, Zhang S, Liu P, Koroleva M, Si S, Little PJ, Pelisek J, Jin ZG
Theranostics8(11)3007-3021(2018)

Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.
Sun M, Long J, Yi Y, Xia W
Endocrine journal64(10)963-975(2017 Oct)

The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors.
Chieosilapatham P, Niyonsaba F, Kiatsurayanon C, Okumura K, Ikeda S, Ogawa H
Journal of dermatological science88(1)117-125(2017 Oct)

MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling.
Pan J, Li K, Huang W, Zhang X
PloS one12(10)e0186245(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IGFBP5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IGFBP5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu107371	NM_000599.4 Latest version!	Homo sapiens insulin like growth factor binding protein 5 (IGFBP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu02488	NM_000599.3 Latest version!	Homo sapiens insulin like growth factor binding protein 5 (IGFBP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IGFBP5 ( NM_000599.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000590.1 Homo sapiens insulin like growth factor binding protein 5 (IGFBP5), mRNA.

Price & Availability↑

CloneID	OHu107371
Clone ID Related Accession (Same CDS sequence)	NM_000599.4
Accession Version	NM_000599.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569427200000
Organism	Homo sapiens(human)
Product	insulin-like growth factor-binding protein 5 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC007563.2. On Nov 23, 2018 this sequence version replaced NM_000599.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF055033.1, ERR279874.3369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000233813.5/ ENSP00000233813.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGTTGC TCACCGCGGT CCTCCTGCTG CTGGCCGCCT ATGCGGGGCC GGCCCAGAGC 
CTGGGCTCCT TCGTGCACTG CGAGCCCTGC GACGAGAAAG CCCTCTCCAT GTGCCCCCCC 
AGCCCCCTGG GCTGCGAGCT GGTCAAGGAG CCGGGCTGCG GCTGCTGCAT GACCTGCGCC 
CTGGCCGAGG GGCAGTCGTG CGGCGTCTAC ACCGAGCGCT GCGCCCAGGG GCTGCGCTGC 
CTCCCCCGGC AGGACGAGGA GAAGCCGCTG CACGCCCTGC TGCACGGCCG CGGGGTTTGC 
CTCAACGAAA AGAGCTACCG CGAGCAAGTC AAGATCGAGA GAGACTCCCG TGAGCACGAG 
GAGCCCACCA CCTCTGAGAT GGCCGAGGAG ACCTACTCCC CCAAGATCTT CCGGCCCAAA 
CACACCCGCA TCTCCGAGCT GAAGGCTGAA GCAGTGAAGA AGGACCGCAG AAAGAAGCTG 
ACCCAGTCCA AGTTTGTCGG GGGAGCCGAG AACACTGCCC ACCCCCGGAT CATCTCTGCA 
CCTGAGATGA GACAGGAGTC TGAGCAGGGC CCCTGCCGCA GACACATGGA GGCTTCCCTG 
CAGGAGCTCA AAGCCAGCCC ACGCATGGTG CCCCGTGCTG TGTACCTGCC CAATTGTGAC 
CGCAAAGGAT TCTACAAGAG AAAGCAGTGC AAACCTTCCC GTGGCCGCAA ACGTGGCATC 
TGCTGGTGCG TGGACAAGTA CGGGATGAAG CTGCCAGGCA TGGAGTACGT TGACGGGGAC 
TTTCAGTGCC ACACCTTCGA CAGCAGCAAC GTTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000590.1
CDS	775..1593
Translation	MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE

Target ORF information:

RefSeq Version	NM_000599.4
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like growth factor binding protein 5 (IGFBP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000599.4

ORF Insert Sequence:

ATGGTGTTGC TCACCGCGGT CCTCCTGCTG CTGGCCGCCT ATGCGGGGCC GGCCCAGAGC 
CTGGGCTCCT TCGTGCACTG CGAGCCCTGC GACGAGAAAG CCCTCTCCAT GTGCCCCCCC 
AGCCCCCTGG GCTGCGAGCT GGTCAAGGAG CCGGGCTGCG GCTGCTGCAT GACCTGCGCC 
CTGGCCGAGG GGCAGTCGTG CGGCGTCTAC ACCGAGCGCT GCGCCCAGGG GCTGCGCTGC 
CTCCCCCGGC AGGACGAGGA GAAGCCGCTG CACGCCCTGC TGCACGGCCG CGGGGTTTGC 
CTCAACGAAA AGAGCTACCG CGAGCAAGTC AAGATCGAGA GAGACTCCCG TGAGCACGAG 
GAGCCCACCA CCTCTGAGAT GGCCGAGGAG ACCTACTCCC CCAAGATCTT CCGGCCCAAA 
CACACCCGCA TCTCCGAGCT GAAGGCTGAA GCAGTGAAGA AGGACCGCAG AAAGAAGCTG 
ACCCAGTCCA AGTTTGTCGG GGGAGCCGAG AACACTGCCC ACCCCCGGAT CATCTCTGCA 
CCTGAGATGA GACAGGAGTC TGAGCAGGGC CCCTGCCGCA GACACATGGA GGCTTCCCTG 
CAGGAGCTCA AAGCCAGCCC ACGCATGGTG CCCCGTGCTG TGTACCTGCC CAATTGTGAC 
CGCAAAGGAT TCTACAAGAG AAAGCAGTGC AAACCTTCCC GTGGCCGCAA ACGTGGCATC 
TGCTGGTGCG TGGACAAGTA CGGGATGAAG CTGCCAGGCA TGGAGTACGT TGACGGGGAC 
TTTCAGTGCC ACACCTTCGA CAGCAGCAAC GTTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IGFBP5 ( NM_000599.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000590.1 Homo sapiens insulin like growth factor binding protein 5 (IGFBP5), mRNA.

Price & Availability↑

CloneID	OHu02488
Clone ID Related Accession (Same CDS sequence)	NM_000599.3
Accession Version	NM_000599.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514304000000
Organism	Homo sapiens(human)
Product	insulin-like growth factor-binding protein 5 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA691367.1, AF055033.1, AC007563.2 and BC032366.1. On Mar 29, 2008 this sequence version replaced NM_000599.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF055033.1, ERR279874.3369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTGTTGC TCACCGCGGT CCTCCTGCTG CTGGCCGCCT ATGCGGGGCC GGCCCAGAGC 
CTGGGCTCCT TCGTGCACTG CGAGCCCTGC GACGAGAAAG CCCTCTCCAT GTGCCCCCCC 
AGCCCCCTGG GCTGCGAGCT GGTCAAGGAG CCGGGCTGCG GCTGCTGCAT GACCTGCGCC 
CTGGCCGAGG GGCAGTCGTG CGGCGTCTAC ACCGAGCGCT GCGCCCAGGG GCTGCGCTGC 
CTCCCCCGGC AGGACGAGGA GAAGCCGCTG CACGCCCTGC TGCACGGCCG CGGGGTTTGC 
CTCAACGAAA AGAGCTACCG CGAGCAAGTC AAGATCGAGA GAGACTCCCG TGAGCACGAG 
GAGCCCACCA CCTCTGAGAT GGCCGAGGAG ACCTACTCCC CCAAGATCTT CCGGCCCAAA 
CACACCCGCA TCTCCGAGCT GAAGGCTGAA GCAGTGAAGA AGGACCGCAG AAAGAAGCTG 
ACCCAGTCCA AGTTTGTCGG GGGAGCCGAG AACACTGCCC ACCCCCGGAT CATCTCTGCA 
CCTGAGATGA GACAGGAGTC TGAGCAGGGC CCCTGCCGCA GACACATGGA GGCTTCCCTG 
CAGGAGCTCA AAGCCAGCCC ACGCATGGTG CCCCGTGCTG TGTACCTGCC CAATTGTGAC 
CGCAAAGGAT TCTACAAGAG AAAGCAGTGC AAACCTTCCC GTGGCCGCAA GCGTGGCATC 
TGCTGGTGCG TGGACAAGTA CGGGATGAAG CTGCCAGGCA TGGAGTACGT TGACGGGGAC 
TTTCAGTGCC ACACCTTCGA CAGCAGCAAC GTTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000590.1
CDS	775..1593
Translation	MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE

Target ORF information:

RefSeq Version	NM_000599.3
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like growth factor binding protein 5 (IGFBP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000599.3

ORF Insert Sequence:

ATGGTGTTGC TCACCGCGGT CCTCCTGCTG CTGGCCGCCT ATGCGGGGCC GGCCCAGAGC 
CTGGGCTCCT TCGTGCACTG CGAGCCCTGC GACGAGAAAG CCCTCTCCAT GTGCCCCCCC 
AGCCCCCTGG GCTGCGAGCT GGTCAAGGAG CCGGGCTGCG GCTGCTGCAT GACCTGCGCC 
CTGGCCGAGG GGCAGTCGTG CGGCGTCTAC ACCGAGCGCT GCGCCCAGGG GCTGCGCTGC 
CTCCCCCGGC AGGACGAGGA GAAGCCGCTG CACGCCCTGC TGCACGGCCG CGGGGTTTGC 
CTCAACGAAA AGAGCTACCG CGAGCAAGTC AAGATCGAGA GAGACTCCCG TGAGCACGAG 
GAGCCCACCA CCTCTGAGAT GGCCGAGGAG ACCTACTCCC CCAAGATCTT CCGGCCCAAA 
CACACCCGCA TCTCCGAGCT GAAGGCTGAA GCAGTGAAGA AGGACCGCAG AAAGAAGCTG 
ACCCAGTCCA AGTTTGTCGG GGGAGCCGAG AACACTGCCC ACCCCCGGAT CATCTCTGCA 
CCTGAGATGA GACAGGAGTC TGAGCAGGGC CCCTGCCGCA GACACATGGA GGCTTCCCTG 
CAGGAGCTCA AAGCCAGCCC ACGCATGGTG CCCCGTGCTG TGTACCTGCC CAATTGTGAC 
CGCAAAGGAT TCTACAAGAG AAAGCAGTGC AAACCTTCCC GTGGCCGCAA GCGTGGCATC 
TGCTGGTGCG TGGACAAGTA CGGGATGAAG CTGCCAGGCA TGGAGTACGT TGACGGGGAC 
TTTCAGTGCC ACACCTTCGA CAGCAGCAAC GTTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identifying the key genes and microRNAs in colorectal cancer liver metastasis by bioinformatics analysis and in vitro experiments.
Oncology reports41(1)279-291(2019 Jan)
Zhang T,Guo J,Gu J,Wang Z,Wang G,Li H,Wang J

Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects.
Theranostics8(11)3007-3021(2018)
Xu S,Xu Y,Yin M,Zhang S,Liu P,Koroleva M,Si S,Little PJ,Pelisek J,Jin ZG

Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.
Endocrine journal64(10)963-975(2017 Oct)
Sun M,Long J,Yi Y,Xia W

The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors.
Journal of dermatological science88(1)117-125(2017 Oct)
Chieosilapatham P,Niyonsaba F,Kiatsurayanon C,Okumura K,Ikeda S,Ogawa H

MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling.
PloS one12(10)e0186245(2017)
Pan J,Li K,Huang W,Zhang X