KLHL10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLHL10
Entrez Gene ID	317719
Full Name	kelch like family member 10
Synonyms	SPGF11
General protein information	Preferred Names kelch like family member 10 Names kelch-like protein 10 testicular tissue protein Li 104
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.2
Summary	The protein encoded by this gene belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain a BACK domain and six C-terminal kelch repeats. Kelch domains are thought to form a four stranded beta-sheet blade structure that can fold into a beta-propeller domain when multiple kelch repeats are found together. Mutations in this gene have been associated with oligozoospermia in some infertile males. [provided by RefSeq, Jul 2016].
Disorder MIM:	608778
Disorder Html:	Spermatogenic failure 11, 615081 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_152467.4	NP_689680.2	kelch-like protein 10 isoform 1
NM_001329596.2	NP_001316525.1	kelch-like protein 10 isoform 2
NM_001329596.1	NP_001316525.1	kelch-like protein 10 isoform 2
NM_152467.5	NP_689680.2	kelch-like protein 10 isoform 1
NM_001329595.1	NP_001316524.1	kelch-like protein 10 isoform 1

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003895	XP_308125.5
Pan troglodytes (chimpanzee)	KLHL10	XP_001167701.1
Danio rerio (zebrafish)	LOC100333629	XP_002665162.1
Xenopus tropicalis (tropical clawed frog)	klhl10	XP_002943971.2
Mus musculus (house mouse)	Klhl10	NP_080003.1
Rattus norvegicus (Norway rat)	Klhl10	NP_001001510.1
Drosophila melanogaster (fruit fly)	klhl10	NP_001015101.2
Homo sapiens (human)	KLHL10	NP_689680.2
Danio rerio (zebrafish)	LOC560378	XP_001920255.1
Danio rerio (zebrafish)	LOC560458	XP_688950.1
Canis lupus familiaris (dog)	KLHL10	XP_537641.2
Bos taurus (cattle)	KLHL10	NP_001071501.1
Gallus gallus (chicken)	KLHL10	NP_001264227.1

Gene Ontology
Bibliography

Related articles in PubMed

Update on the Kelch-like (KLHL) gene family.
Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS
Human genomics713(2013 May)

[Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia].
Qiu QM, Liu G, Li WN, Shi QW, Zhu FX, Lu GX
Zhonghua nan ke xue = National journal of andrology15(11)974-9(2009 Nov)

Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization.
Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM
Human molecular genetics15(23)3411-9(2006 Dec)

Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice.
Yan W, Ma L, Burns KH, Matzuk MM
Proceedings of the National Academy of Sciences of the United States of America101(20)7793-8(2004 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KLHL10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLHL10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu101797	NM_001329596.2 Latest version!	Homo sapiens kelch like family member 10 (KLHL10), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu55632	NM_152467.5 Latest version!	Homo sapiens kelch like family member 10 (KLHL10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00
OHu55632	NM_001329595.1 Latest version!	Homo sapiens kelch like family member 10 (KLHL10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00
View Old Accession Versions >>
OHu101797	NM_001329596.1	Homo sapiens kelch like family member 10 (KLHL10), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu55632	NM_152467.4	Homo sapiens kelch like family member 10 (KLHL10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLHL10 ( NM_001329596.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001316525.1 Homo sapiens kelch like family member 10 (KLHL10), transcript variant 3, mRNA.

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CloneID	OHu101797
Clone ID Related Accession (Same CDS sequence)	NM_001329596.2 , NM_001329596.1
Accession Version	NM_001329596.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1559145600000
Organism	Homo sapiens(human)
Product	kelch-like protein 10 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB021233.1, AK301797.1, AY495339.1 and AC125257.4. On May 31, 2019 this sequence version replaced NM_001329596.1. Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in its 5' terminal exon compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK301797.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGAAGC TAATCATTGA GTATGCATAC ACCCGGACCG TGCCTATCAC ACCGGACAAT 
GTGGAGAAAC TGCTTGCTGC TGCAGACCAG TTTAACATCA TGGGTATCGT CAGGGGTTGC 
TGCGAGTTCC TCAAGTCAGA GCTGTGCTTG GATAATTGTA TCGGCATCTG TAAGTTCACG 
GACTACTACT ACTGTCCTGA GCTGAGGCAG AAGGCCTACA TGTTCATACT GCACAACTTT 
GAGGAGATGG TGAAAGTCTC GGCAGAATTT TTAGAGCTCT CGGTCACTGA ACTTAAGGAT 
ATCATTGAGA AAGATGAGCT CAATGTCAAA CAGGAAGATG CTGTATTTGA GGCCATTTTA 
AAGTGGATTT CTCATGACCC CCAAAATAGA AAGCAGCACA TTTCAATTTT GCTTCCTAAG 
GTTCGCCTGG CCCTAATGCA TGCTGAGTAC TTCATGAACA ATGTTAAGAT GAATGACTAT 
GTCAAAGACA GTGAGGAATG CAAACCAGTC ATCATTAATG CCCTAAAGGC CATGTATGAC 
CTCAACATGA ATGGACCCTC TAATTCTGAT TTCACCAACC CACTCACCAG ACCACGCTTG 
CCCTATGCCA TCCTCTTTGC AATTGGTGGC TGGAGTGGTG GGAGCCCCAC CAATGCCATT 
GAGGCATATG ACGCTCGGGC AGACAGATGG GTGAATGTTA CTTGTGAGGA AGAGAGTCCC 
CGTGCCTACC ATGGGGCAGC CTATTTGAAA GGCTATGTGT ATATCATTGG GGGGTTTGAT 
AGTGTAGACT ATTTCAATAG TGTTAAGCGT TTTGACCCAG TCAAGAAAAC TTGGCATCAG 
GTGGCCCCGA TGCACTCCAG ACGTTGCTAT GTCAGTGTGA CAGTCCTCGG CAATTTTATT 
TATGCCATGG GAGGATTTGA TGGCTACGTG CGTCTAAACA CTGCTGAACG TTATGAGCCA 
GAGACCAATC AATGGACACT CATCGCCCCC ATGCACGAAC AGAGGAGTGA TGCAAGCGCC 
ACAACACTTT ATGGGAAGGT CTACATATGT GGTGGGTTTA ATGGAAACGA GTGCCTGTTC 
ACAGCAGAAG TGTATAACAC TGAAAGTAAT CAGTGGACAG TCATAGCACC CATGAGAAGC 
AGGAGGAGTG GAATAGGCGT GATTGCTTAT GGAGAACATG TATATGCGGT AGGTGGCTTT 
GATGGAGCTA ATCGACTTAG GAGTGCCGAA GCCTACAGCC CTGTGGCTAA CACTTGGCGC 
ACAATCCCCA CTATGTTTAA TCCTCGTAGC AATTTTGGCA TCGAGGTGGT GGATGACCTC 
TTGTTTGTGG TGGGTGGCTT TAATGGTTTT ACCACCACCT TTAATGTTGA GTGCTATGAT 
GAAAAGACCG ATGAGTGGTA TGATGCTCAT GACATGAGTA TATACCGCAG TGCTCTGAGC 
TGCTGTGTAG TACCAGGGCT GGCCAATGTT GAGGAATATG CAGCTAGACG GGACAACTTC 
CCAGGATTAG CACTGCGAGA TGAAGTAAAA TATTCTGCTT CGACAAGTAC CCTACCTGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316525.1
CDS	311..1873
Translation	MMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYSASTSTLPV

Target ORF information:

RefSeq Version	NM_001329596.2
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 10 (KLHL10), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329596.2

ORF Insert Sequence:

ATGATGAAGC TAATCATTGA GTATGCATAC ACCCGGACCG TGCCTATCAC ACCGGACAAT 
GTGGAGAAAC TGCTTGCTGC TGCAGACCAG TTTAACATCA TGGGTATCGT CAGGGGTTGC 
TGCGAGTTCC TCAAGTCAGA GCTGTGCTTG GATAATTGTA TCGGCATCTG TAAGTTCACG 
GACTACTACT ACTGTCCTGA GCTGAGGCAG AAGGCCTACA TGTTCATACT GCACAACTTT 
GAGGAGATGG TGAAAGTCTC GGCAGAATTT TTAGAGCTCT CGGTCACTGA ACTTAAGGAT 
ATCATTGAGA AAGATGAGCT CAATGTCAAA CAGGAAGATG CTGTATTTGA GGCCATTTTA 
AAGTGGATTT CTCATGACCC CCAAAATAGA AAGCAGCACA TTTCAATTTT GCTTCCTAAG 
GTTCGCCTGG CCCTAATGCA TGCTGAGTAC TTCATGAACA ATGTTAAGAT GAATGACTAT 
GTCAAAGACA GTGAGGAATG CAAACCAGTC ATCATTAATG CCCTAAAGGC CATGTATGAC 
CTCAACATGA ATGGACCCTC TAATTCTGAT TTCACCAACC CACTCACCAG ACCACGCTTG 
CCCTATGCCA TCCTCTTTGC AATTGGTGGC TGGAGTGGTG GGAGCCCCAC CAATGCCATT 
GAGGCATATG ACGCTCGGGC AGACAGATGG GTGAATGTTA CTTGTGAGGA AGAGAGTCCC 
CGTGCCTACC ATGGGGCAGC CTATTTGAAA GGCTATGTGT ATATCATTGG GGGGTTTGAT 
AGTGTAGACT ATTTCAATAG TGTTAAGCGT TTTGACCCAG TCAAGAAAAC TTGGCATCAG 
GTGGCCCCGA TGCACTCCAG ACGTTGCTAT GTCAGTGTGA CAGTCCTCGG CAATTTTATT 
TATGCCATGG GAGGATTTGA TGGCTACGTG CGTCTAAACA CTGCTGAACG TTATGAGCCA 
GAGACCAATC AATGGACACT CATCGCCCCC ATGCACGAAC AGAGGAGTGA TGCAAGCGCC 
ACAACACTTT ATGGGAAGGT CTACATATGT GGTGGGTTTA ATGGAAACGA GTGCCTGTTC 
ACAGCAGAAG TGTATAACAC TGAAAGTAAT CAGTGGACAG TCATAGCACC CATGAGAAGC 
AGGAGGAGTG GAATAGGCGT GATTGCTTAT GGAGAACATG TATATGCGGT AGGTGGCTTT 
GATGGAGCTA ATCGACTTAG GAGTGCCGAA GCCTACAGCC CTGTGGCTAA CACTTGGCGC 
ACAATCCCCA CTATGTTTAA TCCTCGTAGC AATTTTGGCA TCGAGGTGGT GGATGACCTC 
TTGTTTGTGG TGGGTGGCTT TAATGGTTTT ACCACCACCT TTAATGTTGA GTGCTATGAT 
GAAAAGACCG ATGAGTGGTA TGATGCTCAT GACATGAGTA TATACCGCAG TGCTCTGAGC 
TGCTGTGTAG TACCAGGGCT GGCCAATGTT GAGGAATATG CAGCTAGACG GGACAACTTC 
CCAGGATTAG CACTGCGAGA TGAAGTAAAA TATTCTGCTT CGACAAGTAC CCTACCTGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL10 ( NM_001329596.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001316525.1 Homo sapiens kelch like family member 10 (KLHL10), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu101797
Clone ID Related Accession (Same CDS sequence)	NM_001329596.2 , NM_001329596.1
Accession Version	NM_001329596.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1530288000000
Organism	Homo sapiens(human)
Product	kelch-like protein 10 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB021233.1, AK301797.1 and AY495339.1. Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in its 5' terminal exon compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK301797.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGAAGC TAATCATTGA GTATGCATAC ACCCGGACCG TGCCTATCAC ACCGGACAAT 
GTGGAGAAAC TGCTTGCTGC TGCAGACCAG TTTAACATCA TGGGTATCGT CAGGGGTTGC 
TGCGAGTTCC TCAAGTCAGA GCTGTGCTTG GATAATTGTA TCGGCATCTG TAAGTTCACG 
GACTACTACT ACTGTCCTGA GCTGAGGCAG AAGGCCTACA TGTTCATACT GCACAACTTT 
GAGGAGATGG TGAAAGTCTC GGCAGAATTT TTAGAGCTCT CGGTCACTGA ACTTAAGGAT 
ATCATTGAGA AAGATGAGCT CAATGTCAAA CAGGAAGATG CTGTATTTGA GGCCATTTTA 
AAGTGGATTT CTCATGACCC CCAAAATAGA AAGCAGCACA TTTCAATTTT GCTTCCTAAG 
GTTCGCCTGG CCCTAATGCA TGCTGAGTAC TTCATGAACA ATGTTAAGAT GAATGACTAT 
GTCAAAGACA GTGAGGAATG CAAACCAGTC ATCATTAATG CCCTAAAGGC CATGTATGAC 
CTCAACATGA ATGGACCCTC TAATTCTGAT TTCACCAACC CACTCACCAG ACCACGCTTG 
CCCTATGCCA TCCTCTTTGC AATTGGTGGC TGGAGTGGTG GGAGCCCCAC CAATGCCATT 
GAGGCATATG ACGCTCGGGC AGACAGATGG GTGAATGTTA CTTGTGAGGA AGAGAGTCCC 
CGTGCCTACC ATGGGGCAGC CTATTTGAAA GGCTATGTGT ATATCATTGG GGGGTTTGAT 
AGTGTAGACT ATTTCAATAG TGTTAAGCGT TTTGACCCAG TCAAGAAAAC TTGGCATCAG 
GTGGCCCCGA TGCACTCCAG ACGTTGCTAT GTCAGTGTGA CAGTCCTCGG CAATTTTATT 
TATGCCATGG GAGGATTTGA TGGCTACGTG CGTCTAAACA CTGCTGAACG TTATGAGCCA 
GAGACCAATC AATGGACACT CATCGCCCCC ATGCACGAAC AGAGGAGTGA TGCAAGCGCC 
ACAACACTTT ATGGGAAGGT CTACATATGT GGTGGGTTTA ATGGAAACGA GTGCCTGTTC 
ACAGCAGAAG TGTATAACAC TGAAAGTAAT CAGTGGACAG TCATAGCACC CATGAGAAGC 
AGGAGGAGTG GAATAGGCGT GATTGCTTAT GGAGAACATG TATATGCGGT AGGTGGCTTT 
GATGGAGCTA ATCGACTTAG GAGTGCCGAA GCCTACAGCC CTGTGGCTAA CACTTGGCGC 
ACAATCCCCA CTATGTTTAA TCCTCGTAGC AATTTTGGCA TCGAGGTGGT GGATGACCTC 
TTGTTTGTGG TGGGTGGCTT TAATGGTTTT ACCACCACCT TTAATGTTGA GTGCTATGAT 
GAAAAGACCG ATGAGTGGTA TGATGCTCAT GACATGAGTA TATACCGCAG TGCTCTGAGC 
TGCTGTGTAG TACCAGGGCT GGCCAATGTT GAGGAATATG CAGCTAGACG GGACAACTTC 
CCAGGATTAG CACTGCGAGA TGAAGTAAAA TATTCTGCTT CGACAAGTAC CCTACCTGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316525.1
CDS	356..1918
Translation	MMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYSASTSTLPV

Target ORF information:

RefSeq Version	NM_001329596.1
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 10 (KLHL10), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329596.1

ORF Insert Sequence:

ATGATGAAGC TAATCATTGA GTATGCATAC ACCCGGACCG TGCCTATCAC ACCGGACAAT 
GTGGAGAAAC TGCTTGCTGC TGCAGACCAG TTTAACATCA TGGGTATCGT CAGGGGTTGC 
TGCGAGTTCC TCAAGTCAGA GCTGTGCTTG GATAATTGTA TCGGCATCTG TAAGTTCACG 
GACTACTACT ACTGTCCTGA GCTGAGGCAG AAGGCCTACA TGTTCATACT GCACAACTTT 
GAGGAGATGG TGAAAGTCTC GGCAGAATTT TTAGAGCTCT CGGTCACTGA ACTTAAGGAT 
ATCATTGAGA AAGATGAGCT CAATGTCAAA CAGGAAGATG CTGTATTTGA GGCCATTTTA 
AAGTGGATTT CTCATGACCC CCAAAATAGA AAGCAGCACA TTTCAATTTT GCTTCCTAAG 
GTTCGCCTGG CCCTAATGCA TGCTGAGTAC TTCATGAACA ATGTTAAGAT GAATGACTAT 
GTCAAAGACA GTGAGGAATG CAAACCAGTC ATCATTAATG CCCTAAAGGC CATGTATGAC 
CTCAACATGA ATGGACCCTC TAATTCTGAT TTCACCAACC CACTCACCAG ACCACGCTTG 
CCCTATGCCA TCCTCTTTGC AATTGGTGGC TGGAGTGGTG GGAGCCCCAC CAATGCCATT 
GAGGCATATG ACGCTCGGGC AGACAGATGG GTGAATGTTA CTTGTGAGGA AGAGAGTCCC 
CGTGCCTACC ATGGGGCAGC CTATTTGAAA GGCTATGTGT ATATCATTGG GGGGTTTGAT 
AGTGTAGACT ATTTCAATAG TGTTAAGCGT TTTGACCCAG TCAAGAAAAC TTGGCATCAG 
GTGGCCCCGA TGCACTCCAG ACGTTGCTAT GTCAGTGTGA CAGTCCTCGG CAATTTTATT 
TATGCCATGG GAGGATTTGA TGGCTACGTG CGTCTAAACA CTGCTGAACG TTATGAGCCA 
GAGACCAATC AATGGACACT CATCGCCCCC ATGCACGAAC AGAGGAGTGA TGCAAGCGCC 
ACAACACTTT ATGGGAAGGT CTACATATGT GGTGGGTTTA ATGGAAACGA GTGCCTGTTC 
ACAGCAGAAG TGTATAACAC TGAAAGTAAT CAGTGGACAG TCATAGCACC CATGAGAAGC 
AGGAGGAGTG GAATAGGCGT GATTGCTTAT GGAGAACATG TATATGCGGT AGGTGGCTTT 
GATGGAGCTA ATCGACTTAG GAGTGCCGAA GCCTACAGCC CTGTGGCTAA CACTTGGCGC 
ACAATCCCCA CTATGTTTAA TCCTCGTAGC AATTTTGGCA TCGAGGTGGT GGATGACCTC 
TTGTTTGTGG TGGGTGGCTT TAATGGTTTT ACCACCACCT TTAATGTTGA GTGCTATGAT 
GAAAAGACCG ATGAGTGGTA TGATGCTCAT GACATGAGTA TATACCGCAG TGCTCTGAGC 
TGCTGTGTAG TACCAGGGCT GGCCAATGTT GAGGAATATG CAGCTAGACG GGACAACTTC 
CCAGGATTAG CACTGCGAGA TGAAGTAAAA TATTCTGCTT CGACAAGTAC CCTACCTGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL10 ( NM_152467.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689680.2 Homo sapiens kelch like family member 10 (KLHL10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55632
Clone ID Related Accession (Same CDS sequence)	NM_152467.4 , NM_152467.5 , NM_001329595.1
Accession Version	NM_152467.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1827bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550937600000
Organism	Homo sapiens(human)
Product	kelch-like protein 10 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB021233.1 and AY495339.1. On Jul 20, 2016 this sequence version replaced NM_152467.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: AY495339.1, HM005417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGATGG AGAGCGCGGC GGCCTCCACA CGTTTCCACC AGCCTCACAT GGAGAGGAAG 
ATGAGTGCGA TGGCCTGTGA GATCTTCAAC GAGCTTAGAC TAGAGGGCAA GCTCTGCGAC 
GTGGTCATCA AGGTCAATGG CTTTGAGTTC AGTGCCCATA AGAACATCCT CTGTAGCTGC 
AGTTCCTACT TTAGAGCTTT GTTTACAAGT GGCTGGAACA ACACTGAAAA GAAGGTATAC 
AACATCCCTG GCATTTCTCC CGACATGATG AAGCTAATCA TTGAGTATGC ATACACCCGG 
ACCGTGCCTA TCACACCGGA CAATGTGGAG AAACTGCTTG CTGCTGCAGA CCAGTTTAAC 
ATCATGGGTA TCGTCAGGGG TTGCTGCGAG TTCCTCAAGT CAGAGCTGTG CTTGGATAAT 
TGTATCGGCA TCTGTAAGTT CACGGACTAC TACTACTGTC CTGAGCTGAG GCAGAAGGCC 
TACATGTTCA TACTGCACAA CTTTGAGGAG ATGGTGAAAG TCTCGGCAGA ATTTTTAGAG 
CTCTCGGTCA CTGAACTTAA GGATATCATT GAGAAAGATG AGCTCAATGT CAAACAGGAA 
GATGCTGTAT TTGAGGCCAT TTTAAAGTGG ATTTCTCATG ACCCCCAAAA TAGAAAGCAG 
CACATTTCAA TTTTGCTTCC TAAGGTTCGC CTGGCCCTAA TGCATGCTGA GTACTTCATG 
AACAATGTTA AGATGAATGA CTATGTCAAA GACAGTGAGG AATGCAAACC AGTCATCATT 
AATGCCCTAA AGGCCATGTA TGACCTCAAC ATGAATGGAC CCTCTAATTC TGATTTCACC 
AACCCACTCA CCAGACCACG CTTGCCCTAT GCCATCCTCT TTGCAATTGG TGGCTGGAGT 
GGTGGGAGCC CCACCAATGC CATTGAGGCA TATGACGCTC GGGCAGACAG ATGGGTGAAT 
GTTACTTGTG AGGAAGAGAG TCCCCGTGCC TACCATGGGG CAGCCTATTT GAAAGGCTAT 
GTGTATATCA TTGGGGGGTT TGATAGTGTA GACTATTTCA ATAGTGTTAA GCGTTTTGAC 
CCAGTCAAGA AAACTTGGCA TCAGGTGGCC CCGATGCACT CCAGACGTTG CTATGTCAGT 
GTGACAGTCC TCGGCAATTT TATTTATGCC ATGGGAGGAT TTGATGGCTA CGTGCGTCTA 
AACACTGCTG AACGTTATGA GCCAGAGACC AATCAATGGA CACTCATCGC CCCCATGCAC 
GAACAGAGGA GTGATGCAAG CGCCACAACA CTTTATGGGA AGGTCTACAT ATGTGGTGGG 
TTTAATGGAA ACGAGTGCCT GTTCACAGCA GAAGTGTATA ACACTGAAAG TAATCAGTGG 
ACAGTCATAG CACCCATGAG AAGCAGGAGG AGTGGAATAG GCGTGATTGC TTATGGAGAA 
CATGTATATG CGGTAGGTGG CTTTGATGGA GCTAATCGAC TTAGGAGTGC CGAAGCCTAC 
AGCCCTGTGG CTAACACTTG GCGCACAATC CCCACTATGT TTAATCCTCG TAGCAATTTT 
GGCATCGAGG TGGTGGATGA CCTCTTGTTT GTGGTGGGTG GCTTTAATGG TTTTACCACC 
ACCTTTAATG TTGAGTGCTA TGATGAAAAG ACCGATGAGT GGTATGATGC TCATGACATG 
AGTATATACC GCAGTGCTCT GAGCTGCTGT GTAGTACCAG GGCTGGCCAA TGTTGAGGAA 
TATGCAGCTA GACGGGACAA CTTCCCAGGA TTAGCACTGC GAGATGAAGT AAAATATTCT 
GCTTCGACAA GTACCCTACC TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689680.2
CDS	154..1980
Translation	MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYSASTSTLPV

Target ORF information:

RefSeq Version	NM_152467.4
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 10 (KLHL10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152467.4

ORF Insert Sequence:

ATGGAGATGG AGAGCGCGGC GGCCTCCACA CGTTTCCACC AGCCTCACAT GGAGAGGAAG 
ATGAGTGCGA TGGCCTGTGA GATCTTCAAC GAGCTTAGAC TAGAGGGCAA GCTCTGCGAC 
GTGGTCATCA AGGTCAATGG CTTTGAGTTC AGTGCCCATA AGAACATCCT CTGTAGCTGC 
AGTTCCTACT TTAGAGCTTT GTTTACAAGT GGCTGGAACA ACACTGAAAA GAAGGTATAC 
AACATCCCTG GCATTTCTCC CGACATGATG AAGCTAATCA TTGAGTATGC ATACACCCGG 
ACCGTGCCTA TCACACCGGA CAATGTGGAG AAACTGCTTG CTGCTGCAGA CCAGTTTAAC 
ATCATGGGTA TCGTCAGGGG TTGCTGCGAG TTCCTCAAGT CAGAGCTGTG CTTGGATAAT 
TGTATCGGCA TCTGTAAGTT CACGGACTAC TACTACTGTC CTGAGCTGAG GCAGAAGGCC 
TACATGTTCA TACTGCACAA CTTTGAGGAG ATGGTGAAAG TCTCGGCAGA ATTTTTAGAG 
CTCTCGGTCA CTGAACTTAA GGATATCATT GAGAAAGATG AGCTCAATGT CAAACAGGAA 
GATGCTGTAT TTGAGGCCAT TTTAAAGTGG ATTTCTCATG ACCCCCAAAA TAGAAAGCAG 
CACATTTCAA TTTTGCTTCC TAAGGTTCGC CTGGCCCTAA TGCATGCTGA GTACTTCATG 
AACAATGTTA AGATGAATGA CTATGTCAAA GACAGTGAGG AATGCAAACC AGTCATCATT 
AATGCCCTAA AGGCCATGTA TGACCTCAAC ATGAATGGAC CCTCTAATTC TGATTTCACC 
AACCCACTCA CCAGACCACG CTTGCCCTAT GCCATCCTCT TTGCAATTGG TGGCTGGAGT 
GGTGGGAGCC CCACCAATGC CATTGAGGCA TATGACGCTC GGGCAGACAG ATGGGTGAAT 
GTTACTTGTG AGGAAGAGAG TCCCCGTGCC TACCATGGGG CAGCCTATTT GAAAGGCTAT 
GTGTATATCA TTGGGGGGTT TGATAGTGTA GACTATTTCA ATAGTGTTAA GCGTTTTGAC 
CCAGTCAAGA AAACTTGGCA TCAGGTGGCC CCGATGCACT CCAGACGTTG CTATGTCAGT 
GTGACAGTCC TCGGCAATTT TATTTATGCC ATGGGAGGAT TTGATGGCTA CGTGCGTCTA 
AACACTGCTG AACGTTATGA GCCAGAGACC AATCAATGGA CACTCATCGC CCCCATGCAC 
GAACAGAGGA GTGATGCAAG CGCCACAACA CTTTATGGGA AGGTCTACAT ATGTGGTGGG 
TTTAATGGAA ACGAGTGCCT GTTCACAGCA GAAGTGTATA ACACTGAAAG TAATCAGTGG 
ACAGTCATAG CACCCATGAG AAGCAGGAGG AGTGGAATAG GCGTGATTGC TTATGGAGAA 
CATGTATATG CGGTAGGTGG CTTTGATGGA GCTAATCGAC TTAGGAGTGC CGAAGCCTAC 
AGCCCTGTGG CTAACACTTG GCGCACAATC CCCACTATGT TTAATCCTCG TAGCAATTTT 
GGCATCGAGG TGGTGGATGA CCTCTTGTTT GTGGTGGGTG GCTTTAATGG TTTTACCACC 
ACCTTTAATG TTGAGTGCTA TGATGAAAAG ACCGATGAGT GGTATGATGC TCATGACATG 
AGTATATACC GCAGTGCTCT GAGCTGCTGT GTAGTACCAG GGCTGGCCAA TGTTGAGGAA 
TATGCAGCTA GACGGGACAA CTTCCCAGGA TTAGCACTGC GAGATGAAGT AAAATATTCT 
GCTTCGACAA GTACCCTACC TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL10 ( NM_152467.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_689680.2 Homo sapiens kelch like family member 10 (KLHL10), transcript variant 2, mRNA.

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CloneID	OHu55632
Clone ID Related Accession (Same CDS sequence)	NM_152467.4 , NM_152467.5 , NM_001329595.1
Accession Version	NM_152467.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1827bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571846400000
Organism	Homo sapiens(human)
Product	kelch-like protein 10 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY495339.1 and AC125257.4. On May 17, 2019 this sequence version replaced NM_152467.4. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: SRR5189667.362446.1, HM005417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000293303.5/ ENSP00000293303.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGATGG AGAGCGCGGC GGCCTCCACA CGTTTCCACC AGCCTCACAT GGAGAGGAAG 
ATGAGTGCGA TGGCCTGTGA GATCTTCAAC GAGCTTAGAC TAGAGGGCAA GCTCTGCGAC 
GTGGTCATCA AGGTCAATGG CTTTGAGTTC AGTGCCCATA AGAACATCCT CTGTAGCTGC 
AGTTCCTACT TTAGAGCTTT GTTTACAAGT GGCTGGAACA ACACTGAAAA GAAGGTATAC 
AACATCCCTG GCATTTCTCC CGACATGATG AAGCTAATCA TTGAGTATGC ATACACCCGG 
ACCGTGCCTA TCACACCGGA CAATGTGGAG AAACTGCTTG CTGCTGCAGA CCAGTTTAAC 
ATCATGGGTA TCGTCAGGGG TTGCTGCGAG TTCCTCAAGT CAGAGCTGTG CTTGGATAAT 
TGTATCGGCA TCTGTAAGTT CACGGACTAC TACTACTGTC CTGAGCTGAG GCAGAAGGCC 
TACATGTTCA TACTGCACAA CTTTGAGGAG ATGGTGAAAG TCTCGGCAGA ATTTTTAGAG 
CTCTCGGTCA CTGAACTTAA GGATATCATT GAGAAAGATG AGCTCAATGT CAAACAGGAA 
GATGCTGTAT TTGAGGCCAT TTTAAAGTGG ATTTCTCATG ACCCCCAAAA TAGAAAGCAG 
CACATTTCAA TTTTGCTTCC TAAGGTTCGC CTGGCCCTAA TGCATGCTGA GTACTTCATG 
AACAATGTTA AGATGAATGA CTATGTCAAA GACAGTGAGG AATGCAAACC AGTCATCATT 
AATGCCCTAA AGGCCATGTA TGACCTCAAC ATGAATGGAC CCTCTAATTC TGATTTCACC 
AACCCACTCA CCAGACCACG CTTGCCCTAT GCCATCCTCT TTGCAATTGG TGGCTGGAGT 
GGTGGGAGCC CCACCAATGC CATTGAGGCA TATGACGCTC GGGCAGACAG ATGGGTGAAT 
GTTACTTGTG AGGAAGAGAG TCCCCGTGCC TACCATGGGG CAGCCTATTT GAAAGGCTAT 
GTGTATATCA TTGGGGGGTT TGATAGTGTA GACTATTTCA ATAGTGTTAA GCGTTTTGAC 
CCAGTCAAGA AAACTTGGCA TCAGGTGGCC CCGATGCACT CCAGACGTTG CTATGTCAGT 
GTGACAGTCC TCGGCAATTT TATTTATGCC ATGGGAGGAT TTGATGGCTA CGTGCGTCTA 
AACACTGCTG AACGTTATGA GCCAGAGACC AATCAATGGA CACTCATCGC CCCCATGCAC 
GAACAGAGGA GTGATGCAAG CGCCACAACA CTTTATGGGA AGGTCTACAT ATGTGGTGGG 
TTTAATGGAA ACGAGTGCCT GTTCACAGCA GAAGTGTATA ACACTGAAAG TAATCAGTGG 
ACAGTCATAG CACCCATGAG AAGCAGGAGG AGTGGAATAG GCGTGATTGC TTATGGAGAA 
CATGTATATG CGGTAGGTGG CTTTGATGGA GCTAATCGAC TTAGGAGTGC CGAAGCCTAC 
AGCCCTGTGG CTAACACTTG GCGCACAATC CCCACTATGT TTAATCCTCG TAGCAATTTT 
GGCATCGAGG TGGTGGATGA CCTCTTGTTT GTGGTGGGTG GCTTTAATGG TTTTACCACC 
ACCTTTAATG TTGAGTGCTA TGATGAAAAG ACCGATGAGT GGTATGATGC TCATGACATG 
AGTATATACC GCAGTGCTCT GAGCTGCTGT GTAGTACCAG GGCTGGCCAA TGTTGAGGAA 
TATGCAGCTA GACGGGACAA CTTCCCAGGA TTAGCACTGC GAGATGAAGT AAAATATTCT 
GCTTCGACAA GTACCCTACC TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689680.2
CDS	109..1935
Translation	MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYSASTSTLPV

Target ORF information:

RefSeq Version	NM_152467.5
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 10 (KLHL10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152467.5

ORF Insert Sequence:

ATGGAGATGG AGAGCGCGGC GGCCTCCACA CGTTTCCACC AGCCTCACAT GGAGAGGAAG 
ATGAGTGCGA TGGCCTGTGA GATCTTCAAC GAGCTTAGAC TAGAGGGCAA GCTCTGCGAC 
GTGGTCATCA AGGTCAATGG CTTTGAGTTC AGTGCCCATA AGAACATCCT CTGTAGCTGC 
AGTTCCTACT TTAGAGCTTT GTTTACAAGT GGCTGGAACA ACACTGAAAA GAAGGTATAC 
AACATCCCTG GCATTTCTCC CGACATGATG AAGCTAATCA TTGAGTATGC ATACACCCGG 
ACCGTGCCTA TCACACCGGA CAATGTGGAG AAACTGCTTG CTGCTGCAGA CCAGTTTAAC 
ATCATGGGTA TCGTCAGGGG TTGCTGCGAG TTCCTCAAGT CAGAGCTGTG CTTGGATAAT 
TGTATCGGCA TCTGTAAGTT CACGGACTAC TACTACTGTC CTGAGCTGAG GCAGAAGGCC 
TACATGTTCA TACTGCACAA CTTTGAGGAG ATGGTGAAAG TCTCGGCAGA ATTTTTAGAG 
CTCTCGGTCA CTGAACTTAA GGATATCATT GAGAAAGATG AGCTCAATGT CAAACAGGAA 
GATGCTGTAT TTGAGGCCAT TTTAAAGTGG ATTTCTCATG ACCCCCAAAA TAGAAAGCAG 
CACATTTCAA TTTTGCTTCC TAAGGTTCGC CTGGCCCTAA TGCATGCTGA GTACTTCATG 
AACAATGTTA AGATGAATGA CTATGTCAAA GACAGTGAGG AATGCAAACC AGTCATCATT 
AATGCCCTAA AGGCCATGTA TGACCTCAAC ATGAATGGAC CCTCTAATTC TGATTTCACC 
AACCCACTCA CCAGACCACG CTTGCCCTAT GCCATCCTCT TTGCAATTGG TGGCTGGAGT 
GGTGGGAGCC CCACCAATGC CATTGAGGCA TATGACGCTC GGGCAGACAG ATGGGTGAAT 
GTTACTTGTG AGGAAGAGAG TCCCCGTGCC TACCATGGGG CAGCCTATTT GAAAGGCTAT 
GTGTATATCA TTGGGGGGTT TGATAGTGTA GACTATTTCA ATAGTGTTAA GCGTTTTGAC 
CCAGTCAAGA AAACTTGGCA TCAGGTGGCC CCGATGCACT CCAGACGTTG CTATGTCAGT 
GTGACAGTCC TCGGCAATTT TATTTATGCC ATGGGAGGAT TTGATGGCTA CGTGCGTCTA 
AACACTGCTG AACGTTATGA GCCAGAGACC AATCAATGGA CACTCATCGC CCCCATGCAC 
GAACAGAGGA GTGATGCAAG CGCCACAACA CTTTATGGGA AGGTCTACAT ATGTGGTGGG 
TTTAATGGAA ACGAGTGCCT GTTCACAGCA GAAGTGTATA ACACTGAAAG TAATCAGTGG 
ACAGTCATAG CACCCATGAG AAGCAGGAGG AGTGGAATAG GCGTGATTGC TTATGGAGAA 
CATGTATATG CGGTAGGTGG CTTTGATGGA GCTAATCGAC TTAGGAGTGC CGAAGCCTAC 
AGCCCTGTGG CTAACACTTG GCGCACAATC CCCACTATGT TTAATCCTCG TAGCAATTTT 
GGCATCGAGG TGGTGGATGA CCTCTTGTTT GTGGTGGGTG GCTTTAATGG TTTTACCACC 
ACCTTTAATG TTGAGTGCTA TGATGAAAAG ACCGATGAGT GGTATGATGC TCATGACATG 
AGTATATACC GCAGTGCTCT GAGCTGCTGT GTAGTACCAG GGCTGGCCAA TGTTGAGGAA 
TATGCAGCTA GACGGGACAA CTTCCCAGGA TTAGCACTGC GAGATGAAGT AAAATATTCT 
GCTTCGACAA GTACCCTACC TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL10 ( NM_001329595.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001316524.1 Homo sapiens kelch like family member 10 (KLHL10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55632
Clone ID Related Accession (Same CDS sequence)	NM_152467.4 , NM_152467.5 , NM_001329595.1
Accession Version	NM_001329595.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1827bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1551024000000
Organism	Homo sapiens(human)
Product	kelch-like protein 10 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA361625.1 and AY495339.1. This sequence is a reference standard in the RefSeqGene project. On Jul 20, 2016 this sequence version replaced XM_011524706.2. Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform 1). ##Evidence-Data-START## CDS exon combination :: AY495339.1, HM005417.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGATGG AGAGCGCGGC GGCCTCCACA CGTTTCCACC AGCCTCACAT GGAGAGGAAG 
ATGAGTGCGA TGGCCTGTGA GATCTTCAAC GAGCTTAGAC TAGAGGGCAA GCTCTGCGAC 
GTGGTCATCA AGGTCAATGG CTTTGAGTTC AGTGCCCATA AGAACATCCT CTGTAGCTGC 
AGTTCCTACT TTAGAGCTTT GTTTACAAGT GGCTGGAACA ACACTGAAAA GAAGGTATAC 
AACATCCCTG GCATTTCTCC CGACATGATG AAGCTAATCA TTGAGTATGC ATACACCCGG 
ACCGTGCCTA TCACACCGGA CAATGTGGAG AAACTGCTTG CTGCTGCAGA CCAGTTTAAC 
ATCATGGGTA TCGTCAGGGG TTGCTGCGAG TTCCTCAAGT CAGAGCTGTG CTTGGATAAT 
TGTATCGGCA TCTGTAAGTT CACGGACTAC TACTACTGTC CTGAGCTGAG GCAGAAGGCC 
TACATGTTCA TACTGCACAA CTTTGAGGAG ATGGTGAAAG TCTCGGCAGA ATTTTTAGAG 
CTCTCGGTCA CTGAACTTAA GGATATCATT GAGAAAGATG AGCTCAATGT CAAACAGGAA 
GATGCTGTAT TTGAGGCCAT TTTAAAGTGG ATTTCTCATG ACCCCCAAAA TAGAAAGCAG 
CACATTTCAA TTTTGCTTCC TAAGGTTCGC CTGGCCCTAA TGCATGCTGA GTACTTCATG 
AACAATGTTA AGATGAATGA CTATGTCAAA GACAGTGAGG AATGCAAACC AGTCATCATT 
AATGCCCTAA AGGCCATGTA TGACCTCAAC ATGAATGGAC CCTCTAATTC TGATTTCACC 
AACCCACTCA CCAGACCACG CTTGCCCTAT GCCATCCTCT TTGCAATTGG TGGCTGGAGT 
GGTGGGAGCC CCACCAATGC CATTGAGGCA TATGACGCTC GGGCAGACAG ATGGGTGAAT 
GTTACTTGTG AGGAAGAGAG TCCCCGTGCC TACCATGGGG CAGCCTATTT GAAAGGCTAT 
GTGTATATCA TTGGGGGGTT TGATAGTGTA GACTATTTCA ATAGTGTTAA GCGTTTTGAC 
CCAGTCAAGA AAACTTGGCA TCAGGTGGCC CCGATGCACT CCAGACGTTG CTATGTCAGT 
GTGACAGTCC TCGGCAATTT TATTTATGCC ATGGGAGGAT TTGATGGCTA CGTGCGTCTA 
AACACTGCTG AACGTTATGA GCCAGAGACC AATCAATGGA CACTCATCGC CCCCATGCAC 
GAACAGAGGA GTGATGCAAG CGCCACAACA CTTTATGGGA AGGTCTACAT ATGTGGTGGG 
TTTAATGGAA ACGAGTGCCT GTTCACAGCA GAAGTGTATA ACACTGAAAG TAATCAGTGG 
ACAGTCATAG CACCCATGAG AAGCAGGAGG AGTGGAATAG GCGTGATTGC TTATGGAGAA 
CATGTATATG CGGTAGGTGG CTTTGATGGA GCTAATCGAC TTAGGAGTGC CGAAGCCTAC 
AGCCCTGTGG CTAACACTTG GCGCACAATC CCCACTATGT TTAATCCTCG TAGCAATTTT 
GGCATCGAGG TGGTGGATGA CCTCTTGTTT GTGGTGGGTG GCTTTAATGG TTTTACCACC 
ACCTTTAATG TTGAGTGCTA TGATGAAAAG ACCGATGAGT GGTATGATGC TCATGACATG 
AGTATATACC GCAGTGCTCT GAGCTGCTGT GTAGTACCAG GGCTGGCCAA TGTTGAGGAA 
TATGCAGCTA GACGGGACAA CTTCCCAGGA TTAGCACTGC GAGATGAAGT AAAATATTCT 
GCTTCGACAA GTACCCTACC TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316524.1
CDS	276..2102
Translation	MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYSASTSTLPV

Target ORF information:

RefSeq Version	NM_001329595.1
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 10 (KLHL10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329595.1

ORF Insert Sequence:

ATGGAGATGG AGAGCGCGGC GGCCTCCACA CGTTTCCACC AGCCTCACAT GGAGAGGAAG 
ATGAGTGCGA TGGCCTGTGA GATCTTCAAC GAGCTTAGAC TAGAGGGCAA GCTCTGCGAC 
GTGGTCATCA AGGTCAATGG CTTTGAGTTC AGTGCCCATA AGAACATCCT CTGTAGCTGC 
AGTTCCTACT TTAGAGCTTT GTTTACAAGT GGCTGGAACA ACACTGAAAA GAAGGTATAC 
AACATCCCTG GCATTTCTCC CGACATGATG AAGCTAATCA TTGAGTATGC ATACACCCGG 
ACCGTGCCTA TCACACCGGA CAATGTGGAG AAACTGCTTG CTGCTGCAGA CCAGTTTAAC 
ATCATGGGTA TCGTCAGGGG TTGCTGCGAG TTCCTCAAGT CAGAGCTGTG CTTGGATAAT 
TGTATCGGCA TCTGTAAGTT CACGGACTAC TACTACTGTC CTGAGCTGAG GCAGAAGGCC 
TACATGTTCA TACTGCACAA CTTTGAGGAG ATGGTGAAAG TCTCGGCAGA ATTTTTAGAG 
CTCTCGGTCA CTGAACTTAA GGATATCATT GAGAAAGATG AGCTCAATGT CAAACAGGAA 
GATGCTGTAT TTGAGGCCAT TTTAAAGTGG ATTTCTCATG ACCCCCAAAA TAGAAAGCAG 
CACATTTCAA TTTTGCTTCC TAAGGTTCGC CTGGCCCTAA TGCATGCTGA GTACTTCATG 
AACAATGTTA AGATGAATGA CTATGTCAAA GACAGTGAGG AATGCAAACC AGTCATCATT 
AATGCCCTAA AGGCCATGTA TGACCTCAAC ATGAATGGAC CCTCTAATTC TGATTTCACC 
AACCCACTCA CCAGACCACG CTTGCCCTAT GCCATCCTCT TTGCAATTGG TGGCTGGAGT 
GGTGGGAGCC CCACCAATGC CATTGAGGCA TATGACGCTC GGGCAGACAG ATGGGTGAAT 
GTTACTTGTG AGGAAGAGAG TCCCCGTGCC TACCATGGGG CAGCCTATTT GAAAGGCTAT 
GTGTATATCA TTGGGGGGTT TGATAGTGTA GACTATTTCA ATAGTGTTAA GCGTTTTGAC 
CCAGTCAAGA AAACTTGGCA TCAGGTGGCC CCGATGCACT CCAGACGTTG CTATGTCAGT 
GTGACAGTCC TCGGCAATTT TATTTATGCC ATGGGAGGAT TTGATGGCTA CGTGCGTCTA 
AACACTGCTG AACGTTATGA GCCAGAGACC AATCAATGGA CACTCATCGC CCCCATGCAC 
GAACAGAGGA GTGATGCAAG CGCCACAACA CTTTATGGGA AGGTCTACAT ATGTGGTGGG 
TTTAATGGAA ACGAGTGCCT GTTCACAGCA GAAGTGTATA ACACTGAAAG TAATCAGTGG 
ACAGTCATAG CACCCATGAG AAGCAGGAGG AGTGGAATAG GCGTGATTGC TTATGGAGAA 
CATGTATATG CGGTAGGTGG CTTTGATGGA GCTAATCGAC TTAGGAGTGC CGAAGCCTAC 
AGCCCTGTGG CTAACACTTG GCGCACAATC CCCACTATGT TTAATCCTCG TAGCAATTTT 
GGCATCGAGG TGGTGGATGA CCTCTTGTTT GTGGTGGGTG GCTTTAATGG TTTTACCACC 
ACCTTTAATG TTGAGTGCTA TGATGAAAAG ACCGATGAGT GGTATGATGC TCATGACATG 
AGTATATACC GCAGTGCTCT GAGCTGCTGT GTAGTACCAG GGCTGGCCAA TGTTGAGGAA 
TATGCAGCTA GACGGGACAA CTTCCCAGGA TTAGCACTGC GAGATGAAGT AAAATATTCT 
GCTTCGACAA GTACCCTACC TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Update on the Kelch-like (KLHL) gene family.
Human genomics713(2013 May)
Dhanoa BS,Cogliati T,Satish AG,Bruford EA,Friedman JS

[Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia].
Zhonghua nan ke xue = National journal of andrology15(11)974-9(2009 Nov)
Qiu QM,Liu G,Li WN,Shi QW,Zhu FX,Lu GX

Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization.
Human molecular genetics15(23)3411-9(2006 Dec)
Yatsenko AN,Roy A,Chen R,Ma L,Murthy LJ,Yan W,Lamb DJ,Matzuk MM

Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice.
Proceedings of the National Academy of Sciences of the United States of America101(20)7793-8(2004 May)
Yan W,Ma L,Burns KH,Matzuk MM

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KLHL10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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