ERO1A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ERO1A
Entrez Gene ID	30001
Full Name	endoplasmic reticulum oxidoreductase 1 alpha
Synonyms	ERO1-L,ERO1-L-alpha,ERO1-alpha,ERO1L,ERO1LA,Ero1alpha
General protein information	Preferred Names endoplasmic reticulum oxidoreductase 1 alpha Names ERO1-like protein alpha endoplasmic oxidoreductin-1-like protein endoplasmic reticulum oxidoreductase alpha oxidoreductin-1-L-alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q22.1
Disorder MIM:	615435

mRNA and Protein(s)

mRNA	Protein	Name
XM_011536684.2	XP_011534986.1	ERO1-like protein alpha isoform X2
NM_014584.2	NP_055399.1	ERO1-like protein alpha precursor
XM_024449554.1	XP_024305322.1	ERO1-like protein alpha isoform X1
NM_014584.3	NP_055399.1	ERO1-like protein alpha precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	ERO1L	XP_001103965.1
Danio rerio (zebrafish)	ero1l	NP_956644.1
Xenopus tropicalis (tropical clawed frog)	ero1lb	NP_001016058.1
Magnaporthe oryzae (rice blast fungus)	MGG_00683	XP_003718326.1
Kluyveromyces lactis	KLLA0D10241g	XP_453517.1
Schizosaccharomyces pombe (fission yeast)	ero12	NP_588313.2
Eremothecium gossypii	AGOS_ADL348W	NP_983747.2
Pan troglodytes (chimpanzee)	ERO1L	XP_509950.2
Canis lupus familiaris (dog)	ERO1L	XP_547813.2
Mus musculus (house mouse)	Ero1l	NP_056589.1
Arabidopsis thaliana (thale cress)	ERO1	NP_177372.1
Gallus gallus (chicken)	ERO1L	NP_001264498.1
Saccharomyces cerevisiae (baker's yeast)	ERO1	NP_013576.1
Arabidopsis thaliana (thale cress)	ERO2	NP_973637.1
Bos taurus (cattle)	ERO1L	NP_001096818.1
Oryza sativa (rice)	Os03g0733800	NP_001051175.2
Neurospora crassa	NCU02074	XP_964601.1
Homo sapiens (human)	ERO1L	NP_055399.1
Rattus norvegicus (Norway rat)	Ero1l	NP_612537.1

Gene Ontology
Bibliography

Related articles in PubMed

ERO1α is a novel endogenous marker of hypoxia in human cancer cell lines.
Takei N, Yoneda A, Kosaka M, Sakai-Sawada K, Tamura Y
BMC cancer19(1)510(2019 May)

Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer.
Zhang Y, Li T, Zhang L, Shangguan F, Shi G, Wu X, Cui Y, Wang X, Wang X, Liu Y, Lu B, Wei T, Wang CC, Wang L
EBioMedicine41408-419(2019 Mar)

ERO1L promotes pancreatic cancer cell progression through activating the Wnt/catenin pathway.
Han F, Xu Q, Zhao J, Xiong P, Liu J
Journal of cellular biochemistry119(11)8996-9005(2018 11)

Endoplasmic reticulum resident oxidase ERO1-Lalpha promotes hepatocellular carcinoma metastasis and angiogenesis through the S1PR1/STAT3/VEGF-A pathway.
Yang S, Yang C, Yu F, Ding W, Hu Y, Cheng F, Zhang F, Guan B, Wang X, Lu L, Rao J
Cell death & disease9(11)1105(2018 10)

Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α.
Zhang J, Zhu Q, Wang X, Yu J, Chen X, Wang J, Wang X, Xiao J, Wang CC, Wang L
The EMBO journal37(14)(2018 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ERO1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ERO1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu103885	XM_024449554.1 Latest version!	Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu67463	XM_011536684.2 Latest version!	Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu06553	NM_014584.3 Latest version!	Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu06553	NM_014584.2	Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ERO1A ( XM_024449554.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305322.1 Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu103885
Clone ID Related Accession (Same CDS sequence)	XM_024449554.1
Accession Version	XM_024449554.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1494bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	ERO1-like protein alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCCGCG GCTGGGGATT CTTGTTTGGC CTCCTGGGCG CCGTGTGGCT GCTCAGCTCG 
GGCCACGGAG AGGAGCAGCC CCCGGAGACA GCGGCACAGA GGTGCTTCTG CCAGGTTAGT 
GGTTACTTGG ATGATTGTAC CTGTGATGTT GAAACCATTG ATAGATTTAA TAACTACAGG 
CTTTTCCCAA GACTACAAAA ACTTCTTGAA AGTGACTACT TTAGGTATTA CAAGGTAAAC 
CTGAAGAGGC CGTGTCCTTT CTGGAATGAC ATCAGCCAGT GTGGAAGAAG GGACTGTGCT 
GTCAAACCAT GTCAATCTGA TGAAGTTCCT GATGGAATTA AATCTGCGAG CTACAAGTAT 
TCTGAAGAAG CCAATAATCT CATTGAAGAA TGTGAACAAG CTGAACGACT TGGAGCAGTG 
GATGAATCTC TGAGTGAGGA AACACAGAAG GCTGTTCTTC AGTGGACCAA GCATGATGAT 
TCTTCAGATA ACTTCTGTGA AGCTGATGAC ATTCAGTCCC CTGAAGCTGA ATATGTAGAT 
TTGCTTCTTA ATCCTGAGCG CTACACTGGT TACAAGGGAC CAGATGCTTG GAAAATATGG 
AATGTCATCT ACGAAGAAAA CTGTTTTAAG CCACAGACAA TTAAAAGACC TTTAAATCCT 
TTGGCTTCTG GTCAAGGGAC AAGTGAAGAG AACACTTTTT ACAGTTGGCT AGAAGGTCTC 
TGTGTAGAAA AAAGAGCATT CTACAGACTT ATATCTGGCC TACATGCAAG CATTAATGTG 
CATTTGAGTG CAAGATATCT TTTACAAGAG ACCTGGTTAG AAAAGAAATG GGGACACAAC 
ATTACAGAAT TTCAACAGCG ATTTGATGGA ATTTTGACTG AAGGAGAAGG TCCAAGAAGG 
CTTAAGAACT TGTATTTTCT CTACTTAATA GAACTAAGGG CTTTATCCAA AGTGTTACCA 
TTCTTCGAGC GCCCAGATTT TCAACTCTTT ACTGGAAATA AAATTCAGGA TGAGGAAAAC 
AAAATGTTAC TTCTGGAAAT ACTTCATGAA ATCAAGTCAT TTCCTTTGCA TTTTGATGAG 
AATTCATTTT TTGCTGGGGA TAAAAAAGAA GCACACAAAC TAAAGGAGGA CTTTCGACTG 
CATTTTAGAA ATATTTCAAG AATTATGGAT TGTGTTGGTT GTTTTAAATG TCGTCTGTGG 
GGAAAGCTTC AGGTAAGCAA ATTTAGTCAT TCCTATTTCT CATTTACCCT TTGCATGAAT 
AATTTTCTAA TTTTTCTTTT TTCCTTATTT CTATTACAGA CTCAGGGTTT GGGCACTGCT 
CTGAAGATCT TATTTTCTGA GAAATTGATA GCAAATATGC CAGAAAGTGG ACCTAGTTAT 
GAATTCCATC TAACCAGACA AGAAATAGTA TCATTATTCA ACGCATTTGG AAGAATTTCT 
ACAAGTGTGA AAGAATTAGA AAACTTCAGG AACTTGTTAC AGAATATTCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305322.1
CDS	270..1763
Translation	MGRGWGFLFGLLGAVWLLSSGHGEEQPPETAAQRCFCQVSGYLDDCTCDVETIDRFNNYRLFPRLQKLLESDYFRYYKVNLKRPCPFWNDISQCGRRDCAVKPCQSDEVPDGIKSASYKYSEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEADDIQSPEAEYVDLLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPLNPLASGQGTSEENTFYSWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQETWLEKKWGHNITEFQQRFDGILTEGEGPRRLKNLYFLYLIELRALSKVLPFFERPDFQLFTGNKIQDEENKMLLLEILHEIKSFPLHFDENSFFAGDKKEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQVSKFSHSYFSFTLCMNNFLIFLFSLFLLQTQGLGTALKILFSEKLIANMPESGPSYEFHLTRQEIVSLFNAFGRISTSVKELENFRNLLQNIH

Target ORF information:

RefSeq Version	XM_024449554.1
Organism	Homo sapiens(human)
Definition	Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024449554.1

ORF Insert Sequence:

ATGGGCCGCG GCTGGGGATT CTTGTTTGGC CTCCTGGGCG CCGTGTGGCT GCTCAGCTCG 
GGCCACGGAG AGGAGCAGCC CCCGGAGACA GCGGCACAGA GGTGCTTCTG CCAGGTTAGT 
GGTTACTTGG ATGATTGTAC CTGTGATGTT GAAACCATTG ATAGATTTAA TAACTACAGG 
CTTTTCCCAA GACTACAAAA ACTTCTTGAA AGTGACTACT TTAGGTATTA CAAGGTAAAC 
CTGAAGAGGC CGTGTCCTTT CTGGAATGAC ATCAGCCAGT GTGGAAGAAG GGACTGTGCT 
GTCAAACCAT GTCAATCTGA TGAAGTTCCT GATGGAATTA AATCTGCGAG CTACAAGTAT 
TCTGAAGAAG CCAATAATCT CATTGAAGAA TGTGAACAAG CTGAACGACT TGGAGCAGTG 
GATGAATCTC TGAGTGAGGA AACACAGAAG GCTGTTCTTC AGTGGACCAA GCATGATGAT 
TCTTCAGATA ACTTCTGTGA AGCTGATGAC ATTCAGTCCC CTGAAGCTGA ATATGTAGAT 
TTGCTTCTTA ATCCTGAGCG CTACACTGGT TACAAGGGAC CAGATGCTTG GAAAATATGG 
AATGTCATCT ACGAAGAAAA CTGTTTTAAG CCACAGACAA TTAAAAGACC TTTAAATCCT 
TTGGCTTCTG GTCAAGGGAC AAGTGAAGAG AACACTTTTT ACAGTTGGCT AGAAGGTCTC 
TGTGTAGAAA AAAGAGCATT CTACAGACTT ATATCTGGCC TACATGCAAG CATTAATGTG 
CATTTGAGTG CAAGATATCT TTTACAAGAG ACCTGGTTAG AAAAGAAATG GGGACACAAC 
ATTACAGAAT TTCAACAGCG ATTTGATGGA ATTTTGACTG AAGGAGAAGG TCCAAGAAGG 
CTTAAGAACT TGTATTTTCT CTACTTAATA GAACTAAGGG CTTTATCCAA AGTGTTACCA 
TTCTTCGAGC GCCCAGATTT TCAACTCTTT ACTGGAAATA AAATTCAGGA TGAGGAAAAC 
AAAATGTTAC TTCTGGAAAT ACTTCATGAA ATCAAGTCAT TTCCTTTGCA TTTTGATGAG 
AATTCATTTT TTGCTGGGGA TAAAAAAGAA GCACACAAAC TAAAGGAGGA CTTTCGACTG 
CATTTTAGAA ATATTTCAAG AATTATGGAT TGTGTTGGTT GTTTTAAATG TCGTCTGTGG 
GGAAAGCTTC AGGTAAGCAA ATTTAGTCAT TCCTATTTCT CATTTACCCT TTGCATGAAT 
AATTTTCTAA TTTTTCTTTT TTCCTTATTT CTATTACAGA CTCAGGGTTT GGGCACTGCT 
CTGAAGATCT TATTTTCTGA GAAATTGATA GCAAATATGC CAGAAAGTGG ACCTAGTTAT 
GAATTCCATC TAACCAGACA AGAAATAGTA TCATTATTCA ACGCATTTGG AAGAATTTCT 
ACAAGTGTGA AAGAATTAGA AAACTTCAGG AACTTGTTAC AGAATATTCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ERO1A ( XM_011536684.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011534986.1 Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu67463
Clone ID Related Accession (Same CDS sequence)	XM_011536684.2
Accession Version	XM_011536684.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1395bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	ERO1-like protein alpha isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011536684.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCCGCG GCTGGGGATT CTTGTTTGGC CTCCTGGGCG CCGTGTGGCT GCTCAGCTCG 
GGCCACGGAG AGGAGCAGCC CCCGGAGACA GCGGCACAGA GGTGCTTCTG CCAGGTTAGT 
GGTTACTTGG ATGATTGTAC CTGTGATGTT GAAACCATTG ATAGATTTAA TAACTACAGG 
CTTTTCCCAA GACTACAAAA ACTTCTTGAA AGTGACTACT TTAGGTATTA CAAGGTAAAC 
CTGAAGAGGC CGTGTCCTTT CTGGAATGAC ATCAGCCAGT GTGGAAGAAG GGACTGTGCT 
GTCAAACCAT GTCAATCTGA TGAAGTTCCT GATGGAATTA AATCTGCGAG CTACAAGTAT 
TCTGAAGAAG CCAATAATCT CATTGAAGAA TGTGAACAAG CTGAACGACT TGGAGCAGTG 
GATGAATCTC TGAGTGAGGA AACACAGAAG GCTGTTCTTC AGTGGACCAA GCATGATGAT 
TCTTCAGATA ACTTCTGTGA AGCTGATGAC ATTCAGTCCC CTGAAGCTGA ATATGTAGAT 
TTGCTTCTTA ATCCTGAGCG CTACACTGGT TACAAGGGAC CAGATGCTTG GAAAATATGG 
AATGTCATCT ACGAAGAAAA CTGTTTTAAG CCACAGACAA TTAAAAGACC TTTAAATCCT 
TTGGCTTCTG GTCAAGAGAA CACTTTTTAC AGTTGGCTAG AAGGTCTCTG TGTAGAAAAA 
AGAGCATTCT ACAGACTTAT ATCTGGCCTA CATGCAAGCA TTAATGTGCA TTTGAGTGCA 
AGATATCTTT TACAAGAGAC CTGGTTAGAA AAGAAATGGG GACACAACAT TACAGAATTT 
CAACAGCGAT TTGATGGAAT TTTGACTGAA GGAGAAGGTC CAAGAAGGCT TAAGAACTTG 
TATTTTCTCT ACTTAATAGA ACTAAGGGCT TTATCCAAAG TGTTACCATT CTTCGAGCGC 
CCAGATTTTC AACTCTTTAC TGGAAATAAA ATTCAGGATG AGGAAAACAA AATGTTACTT 
CTGGAAATAC TTCATGAAAT CAAGTCATTT CCTTTGCATT TTGATGAGAA TTCATTTTTT 
GCTGGGGATA AAAAAGAAGC ACACAAACTA AAGGAGGACT TTCGACTGCA TTTTAGAAAT 
ATTTCAAGAA TTATGGATTG TGTTGGTTGT TTTAAATGTC GTCTGTGGGG AAAGCTTCAG 
ACTCAGGGTT TGGGCACTGC TCTGAAGATC TTATTTTCTG AGAAATTGAT AGCAAATATG 
CCAGAAAGTG GACCTAGTTA TGAATTCCAT CTAACCAGAC AAGAAATAGT ATCATTATTC 
AACGCATTTG GAAGAATTTC TACAAGTGTG AAAGAATTAG AAAACTTCAG GAACTTGTTA 
CAGAATATTC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011534986.1
CDS	270..1664
Translation	MGRGWGFLFGLLGAVWLLSSGHGEEQPPETAAQRCFCQVSGYLDDCTCDVETIDRFNNYRLFPRLQKLLESDYFRYYKVNLKRPCPFWNDISQCGRRDCAVKPCQSDEVPDGIKSASYKYSEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEADDIQSPEAEYVDLLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPLNPLASGQENTFYSWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQETWLEKKWGHNITEFQQRFDGILTEGEGPRRLKNLYFLYLIELRALSKVLPFFERPDFQLFTGNKIQDEENKMLLLEILHEIKSFPLHFDENSFFAGDKKEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKLIANMPESGPSYEFHLTRQEIVSLFNAFGRISTSVKELENFRNLLQNIH

Target ORF information:

RefSeq Version	XM_011536684.2
Organism	Homo sapiens(human)
Definition	Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011536684.2

ORF Insert Sequence:

ATGGGCCGCG GCTGGGGATT CTTGTTTGGC CTCCTGGGCG CCGTGTGGCT GCTCAGCTCG 
GGCCACGGAG AGGAGCAGCC CCCGGAGACA GCGGCACAGA GGTGCTTCTG CCAGGTTAGT 
GGTTACTTGG ATGATTGTAC CTGTGATGTT GAAACCATTG ATAGATTTAA TAACTACAGG 
CTTTTCCCAA GACTACAAAA ACTTCTTGAA AGTGACTACT TTAGGTATTA CAAGGTAAAC 
CTGAAGAGGC CGTGTCCTTT CTGGAATGAC ATCAGCCAGT GTGGAAGAAG GGACTGTGCT 
GTCAAACCAT GTCAATCTGA TGAAGTTCCT GATGGAATTA AATCTGCGAG CTACAAGTAT 
TCTGAAGAAG CCAATAATCT CATTGAAGAA TGTGAACAAG CTGAACGACT TGGAGCAGTG 
GATGAATCTC TGAGTGAGGA AACACAGAAG GCTGTTCTTC AGTGGACCAA GCATGATGAT 
TCTTCAGATA ACTTCTGTGA AGCTGATGAC ATTCAGTCCC CTGAAGCTGA ATATGTAGAT 
TTGCTTCTTA ATCCTGAGCG CTACACTGGT TACAAGGGAC CAGATGCTTG GAAAATATGG 
AATGTCATCT ACGAAGAAAA CTGTTTTAAG CCACAGACAA TTAAAAGACC TTTAAATCCT 
TTGGCTTCTG GTCAAGAGAA CACTTTTTAC AGTTGGCTAG AAGGTCTCTG TGTAGAAAAA 
AGAGCATTCT ACAGACTTAT ATCTGGCCTA CATGCAAGCA TTAATGTGCA TTTGAGTGCA 
AGATATCTTT TACAAGAGAC CTGGTTAGAA AAGAAATGGG GACACAACAT TACAGAATTT 
CAACAGCGAT TTGATGGAAT TTTGACTGAA GGAGAAGGTC CAAGAAGGCT TAAGAACTTG 
TATTTTCTCT ACTTAATAGA ACTAAGGGCT TTATCCAAAG TGTTACCATT CTTCGAGCGC 
CCAGATTTTC AACTCTTTAC TGGAAATAAA ATTCAGGATG AGGAAAACAA AATGTTACTT 
CTGGAAATAC TTCATGAAAT CAAGTCATTT CCTTTGCATT TTGATGAGAA TTCATTTTTT 
GCTGGGGATA AAAAAGAAGC ACACAAACTA AAGGAGGACT TTCGACTGCA TTTTAGAAAT 
ATTTCAAGAA TTATGGATTG TGTTGGTTGT TTTAAATGTC GTCTGTGGGG AAAGCTTCAG 
ACTCAGGGTT TGGGCACTGC TCTGAAGATC TTATTTTCTG AGAAATTGAT AGCAAATATG 
CCAGAAAGTG GACCTAGTTA TGAATTCCAT CTAACCAGAC AAGAAATAGT ATCATTATTC 
AACGCATTTG GAAGAATTTC TACAAGTGTG AAAGAATTAG AAAACTTCAG GAACTTGTTA 
CAGAATATTC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ERO1A ( NM_014584.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055399.1 Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), mRNA.

Price & Availability↑

CloneID	OHu06553
Clone ID Related Accession (Same CDS sequence)	NM_014584.2 , NM_014584.3
Accession Version	NM_014584.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1507996800000
Organism	Homo sapiens(human)
Product	ERO1-like protein alpha precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR990477.1, BX420309.2, DR006292.1, BC012941.1 and AL133453.3. On Jan 7, 2015 this sequence version replaced NM_014584.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.179781.1, SRR1660807.40161.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCGCG GCTGGGGATT CTTGTTTGGC CTCCTGGGCG CCGTGTGGCT GCTCAGCTCG 
GGCCACGGAG AGGAGCAGCC CCCGGAGACA GCGGCACAGA GGTGCTTCTG CCAGGTTAGT 
GGTTACTTGG ATGATTGTAC CTGTGATGTT GAAACCATTG ATAGATTTAA TAACTACAGG 
CTTTTCCCAA GACTACAAAA ACTTCTTGAA AGTGACTACT TTAGGTATTA CAAGGTAAAC 
CTGAAGAGGC CGTGTCCTTT CTGGAATGAC ATCAGCCAGT GTGGAAGAAG GGACTGTGCT 
GTCAAACCAT GTCAATCTGA TGAAGTTCCT GATGGAATTA AATCTGCGAG CTACAAGTAT 
TCTGAAGAAG CCAATAATCT CATTGAAGAA TGTGAACAAG CTGAACGACT TGGAGCAGTG 
GATGAATCTC TGAGTGAGGA AACACAGAAG GCTGTTCTTC AGTGGACCAA GCATGATGAT 
TCTTCAGATA ACTTCTGTGA AGCTGATGAC ATTCAGTCCC CTGAAGCTGA ATATGTAGAT 
TTGCTTCTTA ATCCTGAGCG CTACACTGGT TACAAGGGAC CAGATGCTTG GAAAATATGG 
AATGTCATCT ACGAAGAAAA CTGTTTTAAG CCACAGACAA TTAAAAGACC TTTAAATCCT 
TTGGCTTCTG GTCAAGGGAC AAGTGAAGAG AACACTTTTT ACAGTTGGCT AGAAGGTCTC 
TGTGTAGAAA AAAGAGCATT CTACAGACTT ATATCTGGCC TACATGCAAG CATTAATGTG 
CATTTGAGTG CAAGATATCT TTTACAAGAG ACCTGGTTAG AAAAGAAATG GGGACACAAC 
ATTACAGAAT TTCAACAGCG ATTTGATGGA ATTTTGACTG AAGGAGAAGG TCCAAGAAGG 
CTTAAGAACT TGTATTTTCT CTACTTAATA GAACTAAGGG CTTTATCCAA AGTGTTACCA 
TTCTTCGAGC GCCCAGATTT TCAACTCTTT ACTGGAAATA AAATTCAGGA TGAGGAAAAC 
AAAATGTTAC TTCTGGAAAT ACTTCATGAA ATCAAGTCAT TTCCTTTGCA TTTTGATGAG 
AATTCATTTT TTGCTGGGGA TAAAAAAGAA GCACACAAAC TAAAGGAGGA CTTTCGACTG 
CATTTTAGAA ATATTTCAAG AATTATGGAT TGTGTTGGTT GTTTTAAATG TCGTCTGTGG 
GGAAAGCTTC AGACTCAGGG TTTGGGCACT GCTCTGAAGA TCTTATTTTC TGAGAAATTG 
ATAGCAAATA TGCCAGAAAG TGGACCTAGT TATGAATTCC ATCTAACCAG ACAAGAAATA 
GTATCATTAT TCAACGCATT TGGAAGAATT TCTACAAGTG TGAAAGAATT AGAAAACTTC 
AGGAACTTGT TACAGAATAT TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055399.1
CDS	451..1857
Translation	MGRGWGFLFGLLGAVWLLSSGHGEEQPPETAAQRCFCQVSGYLDDCTCDVETIDRFNNYRLFPRLQKLLESDYFRYYKVNLKRPCPFWNDISQCGRRDCAVKPCQSDEVPDGIKSASYKYSEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEADDIQSPEAEYVDLLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPLNPLASGQGTSEENTFYSWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQETWLEKKWGHNITEFQQRFDGILTEGEGPRRLKNLYFLYLIELRALSKVLPFFERPDFQLFTGNKIQDEENKMLLLEILHEIKSFPLHFDENSFFAGDKKEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKLIANMPESGPSYEFHLTRQEIVSLFNAFGRISTSVKELENFRNLLQNIH

Target ORF information:

RefSeq Version	NM_014584.2
Organism	Homo sapiens(human)
Definition	Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014584.2

ORF Insert Sequence:

ATGGGCCGCG GCTGGGGATT CTTGTTTGGC CTCCTGGGCG CCGTGTGGCT GCTCAGCTCG 
GGCCACGGAG AGGAGCAGCC CCCGGAGACA GCGGCACAGA GGTGCTTCTG CCAGGTTAGT 
GGTTACTTGG ATGATTGTAC CTGTGATGTT GAAACCATTG ATAGATTTAA TAACTACAGG 
CTTTTCCCAA GACTACAAAA ACTTCTTGAA AGTGACTACT TTAGGTATTA CAAGGTAAAC 
CTGAAGAGGC CGTGTCCTTT CTGGAATGAC ATCAGCCAGT GTGGAAGAAG GGACTGTGCT 
GTCAAACCAT GTCAATCTGA TGAAGTTCCT GATGGAATTA AATCTGCGAG CTACAAGTAT 
TCTGAAGAAG CCAATAATCT CATTGAAGAA TGTGAACAAG CTGAACGACT TGGAGCAGTG 
GATGAATCTC TGAGTGAGGA AACACAGAAG GCTGTTCTTC AGTGGACCAA GCATGATGAT 
TCTTCAGATA ACTTCTGTGA AGCTGATGAC ATTCAGTCCC CTGAAGCTGA ATATGTAGAT 
TTGCTTCTTA ATCCTGAGCG CTACACTGGT TACAAGGGAC CAGATGCTTG GAAAATATGG 
AATGTCATCT ACGAAGAAAA CTGTTTTAAG CCACAGACAA TTAAAAGACC TTTAAATCCT 
TTGGCTTCTG GTCAAGGGAC AAGTGAAGAG AACACTTTTT ACAGTTGGCT AGAAGGTCTC 
TGTGTAGAAA AAAGAGCATT CTACAGACTT ATATCTGGCC TACATGCAAG CATTAATGTG 
CATTTGAGTG CAAGATATCT TTTACAAGAG ACCTGGTTAG AAAAGAAATG GGGACACAAC 
ATTACAGAAT TTCAACAGCG ATTTGATGGA ATTTTGACTG AAGGAGAAGG TCCAAGAAGG 
CTTAAGAACT TGTATTTTCT CTACTTAATA GAACTAAGGG CTTTATCCAA AGTGTTACCA 
TTCTTCGAGC GCCCAGATTT TCAACTCTTT ACTGGAAATA AAATTCAGGA TGAGGAAAAC 
AAAATGTTAC TTCTGGAAAT ACTTCATGAA ATCAAGTCAT TTCCTTTGCA TTTTGATGAG 
AATTCATTTT TTGCTGGGGA TAAAAAAGAA GCACACAAAC TAAAGGAGGA CTTTCGACTG 
CATTTTAGAA ATATTTCAAG AATTATGGAT TGTGTTGGTT GTTTTAAATG TCGTCTGTGG 
GGAAAGCTTC AGACTCAGGG TTTGGGCACT GCTCTGAAGA TCTTATTTTC TGAGAAATTG 
ATAGCAAATA TGCCAGAAAG TGGACCTAGT TATGAATTCC ATCTAACCAG ACAAGAAATA 
GTATCATTAT TCAACGCATT TGGAAGAATT TCTACAAGTG TGAAAGAATT AGAAAACTTC 
AGGAACTTGT TACAGAATAT TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ERO1A ( NM_014584.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055399.1 Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), mRNA.

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CloneID	OHu06553
Clone ID Related Accession (Same CDS sequence)	NM_014584.2 , NM_014584.3
Accession Version	NM_014584.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	ERO1-like protein alpha precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC012941.1 and AL133453.3. On Nov 22, 2018 this sequence version replaced NM_014584.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.179781.1, SRR1660809.161914.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000395686.8/ ENSP00000379042.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCCGCG GCTGGGGATT CTTGTTTGGC CTCCTGGGCG CCGTGTGGCT GCTCAGCTCG 
GGCCACGGAG AGGAGCAGCC CCCGGAGACA GCGGCACAGA GGTGCTTCTG CCAGGTTAGT 
GGTTACTTGG ATGATTGTAC CTGTGATGTT GAAACCATTG ATAGATTTAA TAACTACAGG 
CTTTTCCCAA GACTACAAAA ACTTCTTGAA AGTGACTACT TTAGGTATTA CAAGGTAAAC 
CTGAAGAGGC CGTGTCCTTT CTGGAATGAC ATCAGCCAGT GTGGAAGAAG GGACTGTGCT 
GTCAAACCAT GTCAATCTGA TGAAGTTCCT GATGGAATTA AATCTGCGAG CTACAAGTAT 
TCTGAAGAAG CCAATAATCT CATTGAAGAA TGTGAACAAG CTGAACGACT TGGAGCAGTG 
GATGAATCTC TGAGTGAGGA AACACAGAAG GCTGTTCTTC AGTGGACCAA GCATGATGAT 
TCTTCAGATA ACTTCTGTGA AGCTGATGAC ATTCAGTCCC CTGAAGCTGA ATATGTAGAT 
TTGCTTCTTA ATCCTGAGCG CTACACTGGT TACAAGGGAC CAGATGCTTG GAAAATATGG 
AATGTCATCT ACGAAGAAAA CTGTTTTAAG CCACAGACAA TTAAAAGACC TTTAAATCCT 
TTGGCTTCTG GTCAAGGGAC AAGTGAAGAG AACACTTTTT ACAGTTGGCT AGAAGGTCTC 
TGTGTAGAAA AAAGAGCATT CTACAGACTT ATATCTGGCC TACATGCAAG CATTAATGTG 
CATTTGAGTG CAAGATATCT TTTACAAGAG ACCTGGTTAG AAAAGAAATG GGGACACAAC 
ATTACAGAAT TTCAACAGCG ATTTGATGGA ATTTTGACTG AAGGAGAAGG TCCAAGAAGG 
CTTAAGAACT TGTATTTTCT CTACTTAATA GAACTAAGGG CTTTATCCAA AGTGTTACCA 
TTCTTCGAGC GCCCAGATTT TCAACTCTTT ACTGGAAATA AAATTCAGGA TGAGGAAAAC 
AAAATGTTAC TTCTGGAAAT ACTTCATGAA ATCAAGTCAT TTCCTTTGCA TTTTGATGAG 
AATTCATTTT TTGCTGGGGA TAAAAAAGAA GCACACAAAC TAAAGGAGGA CTTTCGACTG 
CATTTTAGAA ATATTTCAAG AATTATGGAT TGTGTTGGTT GTTTTAAATG TCGTCTGTGG 
GGAAAGCTTC AGACTCAGGG TTTGGGCACT GCTCTGAAGA TCTTATTTTC TGAGAAATTG 
ATAGCAAATA TGCCAGAAAG TGGACCTAGT TATGAATTCC ATCTAACCAG ACAAGAAATA 
GTATCATTAT TCAACGCATT TGGAAGAATT TCTACAAGTG TGAAAGAATT AGAAAACTTC 
AGGAACTTGT TACAGAATAT TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055399.1
CDS	78..1484
Translation	MGRGWGFLFGLLGAVWLLSSGHGEEQPPETAAQRCFCQVSGYLDDCTCDVETIDRFNNYRLFPRLQKLLESDYFRYYKVNLKRPCPFWNDISQCGRRDCAVKPCQSDEVPDGIKSASYKYSEEANNLIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDNFCEADDIQSPEAEYVDLLLNPERYTGYKGPDAWKIWNVIYEENCFKPQTIKRPLNPLASGQGTSEENTFYSWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQETWLEKKWGHNITEFQQRFDGILTEGEGPRRLKNLYFLYLIELRALSKVLPFFERPDFQLFTGNKIQDEENKMLLLEILHEIKSFPLHFDENSFFAGDKKEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKLIANMPESGPSYEFHLTRQEIVSLFNAFGRISTSVKELENFRNLLQNIH

Target ORF information:

RefSeq Version	NM_014584.3
Organism	Homo sapiens(human)
Definition	Homo sapiens endoplasmic reticulum oxidoreductase 1 alpha (ERO1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014584.3

ORF Insert Sequence:

ATGGGCCGCG GCTGGGGATT CTTGTTTGGC CTCCTGGGCG CCGTGTGGCT GCTCAGCTCG 
GGCCACGGAG AGGAGCAGCC CCCGGAGACA GCGGCACAGA GGTGCTTCTG CCAGGTTAGT 
GGTTACTTGG ATGATTGTAC CTGTGATGTT GAAACCATTG ATAGATTTAA TAACTACAGG 
CTTTTCCCAA GACTACAAAA ACTTCTTGAA AGTGACTACT TTAGGTATTA CAAGGTAAAC 
CTGAAGAGGC CGTGTCCTTT CTGGAATGAC ATCAGCCAGT GTGGAAGAAG GGACTGTGCT 
GTCAAACCAT GTCAATCTGA TGAAGTTCCT GATGGAATTA AATCTGCGAG CTACAAGTAT 
TCTGAAGAAG CCAATAATCT CATTGAAGAA TGTGAACAAG CTGAACGACT TGGAGCAGTG 
GATGAATCTC TGAGTGAGGA AACACAGAAG GCTGTTCTTC AGTGGACCAA GCATGATGAT 
TCTTCAGATA ACTTCTGTGA AGCTGATGAC ATTCAGTCCC CTGAAGCTGA ATATGTAGAT 
TTGCTTCTTA ATCCTGAGCG CTACACTGGT TACAAGGGAC CAGATGCTTG GAAAATATGG 
AATGTCATCT ACGAAGAAAA CTGTTTTAAG CCACAGACAA TTAAAAGACC TTTAAATCCT 
TTGGCTTCTG GTCAAGGGAC AAGTGAAGAG AACACTTTTT ACAGTTGGCT AGAAGGTCTC 
TGTGTAGAAA AAAGAGCATT CTACAGACTT ATATCTGGCC TACATGCAAG CATTAATGTG 
CATTTGAGTG CAAGATATCT TTTACAAGAG ACCTGGTTAG AAAAGAAATG GGGACACAAC 
ATTACAGAAT TTCAACAGCG ATTTGATGGA ATTTTGACTG AAGGAGAAGG TCCAAGAAGG 
CTTAAGAACT TGTATTTTCT CTACTTAATA GAACTAAGGG CTTTATCCAA AGTGTTACCA 
TTCTTCGAGC GCCCAGATTT TCAACTCTTT ACTGGAAATA AAATTCAGGA TGAGGAAAAC 
AAAATGTTAC TTCTGGAAAT ACTTCATGAA ATCAAGTCAT TTCCTTTGCA TTTTGATGAG 
AATTCATTTT TTGCTGGGGA TAAAAAAGAA GCACACAAAC TAAAGGAGGA CTTTCGACTG 
CATTTTAGAA ATATTTCAAG AATTATGGAT TGTGTTGGTT GTTTTAAATG TCGTCTGTGG 
GGAAAGCTTC AGACTCAGGG TTTGGGCACT GCTCTGAAGA TCTTATTTTC TGAGAAATTG 
ATAGCAAATA TGCCAGAAAG TGGACCTAGT TATGAATTCC ATCTAACCAG ACAAGAAATA 
GTATCATTAT TCAACGCATT TGGAAGAATT TCTACAAGTG TGAAAGAATT AGAAAACTTC 
AGGAACTTGT TACAGAATAT TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ERO1α is a novel endogenous marker of hypoxia in human cancer cell lines.
BMC cancer19(1)510(2019 May)
Takei N,Yoneda A,Kosaka M,Sakai-Sawada K,Tamura Y

Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer.
EBioMedicine41408-419(2019 Mar)
Zhang Y,Li T,Zhang L,Shangguan F,Shi G,Wu X,Cui Y,Wang X,Wang X,Liu Y,Lu B,Wei T,Wang CC,Wang L

ERO1L promotes pancreatic cancer cell progression through activating the Wnt/catenin pathway.
Journal of cellular biochemistry119(11)8996-9005(2018 11)
Han F,Xu Q,Zhao J,Xiong P,Liu J

Endoplasmic reticulum resident oxidase ERO1-Lalpha promotes hepatocellular carcinoma metastasis and angiogenesis through the S1PR1/STAT3/VEGF-A pathway.
Cell death & disease9(11)1105(2018 10)
Yang S,Yang C,Yu F,Ding W,Hu Y,Cheng F,Zhang F,Guan B,Wang X,Lu L,Rao J

Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α.
The EMBO journal37(14)(2018 07)
Zhang J,Zhu Q,Wang X,Yu J,Chen X,Wang J,Wang X,Xiao J,Wang CC,Wang L

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ERO1A cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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