LRP12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LRP12
Entrez Gene ID	29967
Full Name	LDL receptor related protein 12
Synonyms	ST7
General protein information	Preferred Names LDL receptor related protein 12 Names low-density lipoprotein receptor-related protein 12 suppressor of tumorigenicity 7 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q22.3
Summary	This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001135703.2	NP_001129175.1	low-density lipoprotein receptor-related protein 12 isoform b precursor
NM_013437.4	NP_038465.1	low-density lipoprotein receptor-related protein 12 isoform a precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Lrp12	NP_766402.1
Rattus norvegicus (Norway rat)	Lrp12	NP_001128355.1
Danio rerio (zebrafish)	lrp12	NP_001076537.1
Homo sapiens (human)	LRP12	NP_038465.1
Bos taurus (cattle)	LRP12	NP_001179910.1
Gallus gallus (chicken)	LRP12	XP_418378.4
Pan troglodytes (chimpanzee)	LRP12	XP_519901.2
Canis lupus familiaris (dog)	LRP12	XP_005628015.1
Macaca mulatta (Rhesus monkey)	LRP12	XP_001086530.1
Xenopus tropicalis (tropical clawed frog)	lrp12	XP_002931586.2

Gene Ontology
Bibliography

Related articles in PubMed

Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance.
Grasse S, Lienhard M, Frese S, Kerick M, Steinbach A, Grimm C, Hussong M, Rolff J, Becker M, Dreher F, Schirmer U, Boerno S, Ramisch A, Leschber G, Timmermann B, Grohé C, Lüders H, Vingron M, Fichtner I, Klein S, Odenthal M, Büttner R, Lehrach H, Sültmann H, Herwig R, Schweiger MR
Genome medicine10(1)55(2018 07)

Abundance of LRP12 C-rs9694676 allelic promoter variant in epilepsy-associated gangliogliomas.
Robens BK, Gembé E, Fassunke J, Becker AJ, Schoch S, Grote A
Life sciences15570-5(2016 Jun)

LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization.
Grote A, Robens BK, Blümcke I, Becker AJ, Schoch S, Gembé E
Neurobiology of disease86170-6(2016 Feb)

Genome-wide association study of chronic periodontitis in a general German population.
Teumer A, Holtfreter B, Völker U, Petersmann A, Nauck M, Biffar R, Völzke H, Kroemer HK, Meisel P, Homuth G, Kocher T
Journal of clinical periodontology40(11)977-85(2013 Nov)

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.
Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, Abdrabou W, Fan BJ, Wang DY, Brodeur W, Budenz DL, Caprioli J, Crenshaw A, Crooks K, Delbono E, Doheny KF, Friedman DS, Gaasterland D, Gaasterland T, Laurie C, Lee RK, Lichter PR, Loomis S, Liu Y, Medeiros FA, McCarty C, Mirel D, Moroi SE, Musch DC, Realini A, Rozsa FW, Schuman JS, Scott K, Singh K, Stein JD, Trager EH, Vanveldhuisen P, Vollrath D, Wollstein G, Yoneyama S, Zhang K, Weinreb RN, Ernst J, Kellis M, Masuda T, Zack D, Richards JE, Pericak-Vance M, Pasquale LR, Haines JL
PLoS genetics8(4)e1002654(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following LRP12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LRP12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu12925	NM_001135703.2 Latest version!	Homo sapiens LDL receptor related protein 12 (LRP12), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu12752	NM_013437.4 Latest version!	Homo sapiens LDL receptor related protein 12 (LRP12), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$475.30 $679.00

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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LRP12 ( NM_001135703.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129175.1 Homo sapiens LDL receptor related protein 12 (LRP12), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12925
Clone ID Related Accession (Same CDS sequence)	NM_001135703.2
Accession Version	NM_001135703.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2523bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1555084800000
Organism	Homo sapiens(human)
Product	low-density lipoprotein receptor-related protein 12 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC372924.1, AC090827.11, AK299374.1, AB208957.1 and AI828757.1. On Feb 18, 2010 this sequence version replaced NM_001135703.1. Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: AK299374.1, SRR1660807.92916.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTGTC GCTGGAGCAC AAAAGAGTCT CCGCGGTGGA GGTCTGCGTT GCTCTTGCTT 
TTCCTCGCTG GGGTGTACGC TTGTGGAGAG ACTCCAGAGC AAATACGAGC ACCAAGTGGC 
ATAATCACAA GCCCAGGCTG GCCTTCTGAA TATCCTGCAA AAATCAACTG TAGCTGGTTC 
ATAAGGGCAA ACCCAGGCGA AATCATTACT ATAAGTTTTC AGGATTTTGA TATTCAAGGA 
TCCAGAAGGT GCAATTTGGA CTGGTTGACA ATAGAAACAT ACAAGAATAT TGAAAGTTAC 
AGAGCTTGTG GTTCCACAAT TCCACCTCCG TATATCTCTT CACAAGACCA CATCTGGATT 
AGGTTTCATT CGGATGACAA CATCTCTAGA AAGGGTTTCA GACTGGCATA TTTTTCAGGG 
AAATCTGAGG AACCAAATTG TGCTTGTGAT CAGTTTCGTT GTGGTAATGG AAAGTGTATA 
CCAGAAGCCT GGAAATGTAA TAACATGGAT GAATGTGGAG ATAGTTCCGA TGAAGAGATC 
TGTGCCAAAG AAGCAAATCC TCCAACTGCT GCTGCTTTTC AACCCTGTGC TTACAACCAG 
TTCCAGTGTT TATCCCGTTT TACCAAAGTT TACACTTGCC TCCCCGAATC TTTAAAATGT 
GATGGGAACA TTGACTGCCT TGACCTAGGA GATGAGATAG ACTGTGATGT GCCAACATGT 
GGGCAATGGC TAAAATATTT TTATGGTACT TTTAATTCTC CCAATTATCC AGACTTTTAT 
CCTCCTGGAA GCAATTGCAC CTGGTTAATA GACACTGGTG ATCACCGTAA AGTCATTTTA 
CGCTTCACTG ACTTTAAACT TGATGGTACT GGTTATGGTG ATTATGTCAA AATATATGAT 
GGATTAGAGG AGAATCCACA CAAGCTTTTG CGTGTGTTGA CAGCTTTTGA TTCTCATGCA 
CCTCTTACAG TTGTTTCTTC TTCTGGACAG ATAAGGGTAC ATTTTTGTGC TGATAAAGTG 
AATGCTGCAA GGGGATTTAA TGCTACTTAC CAAGTAGATG GGTTCTGTTT GCCATGGGAA 
ATACCCTGTG GAGGTAACTG GGGGTGTTAT ACTGAGCAGC AGCGTTGTGA TGGGTATTGG 
CATTGCCCAA ATGGAAGGGA TGAAACCAAT TGTACCATGT GCCAGAAGGA AGAATTTCCA 
TGTTCCCGAA ATGGTGTCTG TTATCCTCGT TCTGATCGCT GCAACTACCA GAATCATTGC 
CCAAATGGCT CAGATGAAAA AAACTGCTTT TTTTGCCAAC CAGGAAATTT CCATTGTAAA 
AACAATCGTT GTGTGTTTGA AAGTTGGGTG TGTGATTCTC AAGATGACTG TGGTGATGGC 
AGCGATGAAG AAAATTGCCC AGTAATCGTG CCTACAAGAG TCATCACTGC TGCCGTCATA 
GGGAGCCTCA TCTGTGGCCT GTTACTCGTC ATAGCATTGG GATGTACTTG TAAGCTTTAT 
TCTCTGAGAA TGTTTGAAAG AAGATCATTT GAAACACAGT TGTCAAGAGT GGAAGCAGAA 
TTGTTAAGAA GAGAAGCTCC TCCCTCGTAT GGACAATTGA TTGCTCAGGG TTTAATTCCA 
CCAGTTGAAG ATTTTCCTGT TTGTTCACCT AATCAGGCTT CTGTTTTGGA AAATCTGAGG 
CTAGCGGTAC GATCTCAGCT TGGATTTACT TCAGTCAGGC TTCCTATGGC AGGCAGATCA 
AGCAACATTT GGAACCGTAT TTTTAATTTT GCAAGATCAC GTCATTCTGG GTCATTGGCT 
TTGGTCTCAG CAGATGGAGA TGAGGTTGTC CCTAGTCAGA GTACCAGTAG AGAACCTGAG 
AGAAATCATA CTCACAGAAG TTTGTTTTCC GTGGAGTCTG ATGATACAGA CACAGAAAAT 
GAGAGAAGAG ATATGGCAGG AGCATCTGGT GGGGTTGCAG CTCCTTTGCC TCAAAAAGTC 
CCTCCCACAA CGGCAGTAGA AGCGACAGTA GGAGCATGTG CAAGTTCCTC AACTCAGAGT 
ACCCGAGGTG GTCATGCAGA TAATGGAAGG GATGTGACAA GTGTGGAACC CCCAAGTGTG 
AGTCCAGCAC GTCACCAGCT TACAAGTGCA CTCAGTCGTA TGACTCAGGG GCTACGCTGG 
GTACGTTTTA CATTAGGACG ATCAAGTTCC CTAAGTCAGA ACCAGAGTCC TTTGAGACAA 
CTTGATAATG GGGTAAGTGG AAGAGAAGAT GATGATGATG TTGAAATGCT AATTCCAATT 
TCTGATGGAT CTTCAGACTT TGATGTGAAT GACTGCTCCA GACCTCTTCT TGATCTTGCC 
TCAGATCAAG GACAAGGGCT TAGACAACCA TATAATGCAA CAAATCCTGG AGTAAGGCCA 
AGTAATCGAG ATGGCCCCTG TGAGCGCTGT GGTATTGTCC ACACTGCCCA GATACCAGAC 
ACTTGCTTAG AAGTAACACT GAAAAACGAA ACGAGTGATG ATGAGGCTTT GTTACTTTGT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129175.1
CDS	128..2650
Translation	MACRWSTKESPRWRSALLLLFLAGVYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEALLLC

Target ORF information:

RefSeq Version	NM_001135703.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LDL receptor related protein 12 (LRP12), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135703.2

ORF Insert Sequence:

ATGGCCTGTC GCTGGAGCAC AAAAGAGTCT CCGCGGTGGA GGTCTGCGTT GCTCTTGCTT 
TTCCTCGCTG GGGTGTACGC TTGTGGAGAG ACTCCAGAGC AAATACGAGC ACCAAGTGGC 
ATAATCACAA GCCCAGGCTG GCCTTCTGAA TATCCTGCAA AAATCAACTG TAGCTGGTTC 
ATAAGGGCAA ACCCAGGCGA AATCATTACT ATAAGTTTTC AGGATTTTGA TATTCAAGGA 
TCCAGAAGGT GCAATTTGGA CTGGTTGACA ATAGAAACAT ACAAGAATAT TGAAAGTTAC 
AGAGCTTGTG GTTCCACAAT TCCACCTCCG TATATCTCTT CACAAGACCA CATCTGGATT 
AGGTTTCATT CGGATGACAA CATCTCTAGA AAGGGTTTCA GACTGGCATA TTTTTCAGGG 
AAATCTGAGG AACCAAATTG TGCTTGTGAT CAGTTTCGTT GTGGTAATGG AAAGTGTATA 
CCAGAAGCCT GGAAATGTAA TAACATGGAT GAATGTGGAG ATAGTTCCGA TGAAGAGATC 
TGTGCCAAAG AAGCAAATCC TCCAACTGCT GCTGCTTTTC AACCCTGTGC TTACAACCAG 
TTCCAGTGTT TATCCCGTTT TACCAAAGTT TACACTTGCC TCCCCGAATC TTTAAAATGT 
GATGGGAACA TTGACTGCCT TGACCTAGGA GATGAGATAG ACTGTGATGT GCCAACATGT 
GGGCAATGGC TAAAATATTT TTATGGTACT TTTAATTCTC CCAATTATCC AGACTTTTAT 
CCTCCTGGAA GCAATTGCAC CTGGTTAATA GACACTGGTG ATCACCGTAA AGTCATTTTA 
CGCTTCACTG ACTTTAAACT TGATGGTACT GGTTATGGTG ATTATGTCAA AATATATGAT 
GGATTAGAGG AGAATCCACA CAAGCTTTTG CGTGTGTTGA CAGCTTTTGA TTCTCATGCA 
CCTCTTACAG TTGTTTCTTC TTCTGGACAG ATAAGGGTAC ATTTTTGTGC TGATAAAGTG 
AATGCTGCAA GGGGATTTAA TGCTACTTAC CAAGTAGATG GGTTCTGTTT GCCATGGGAA 
ATACCCTGTG GAGGTAACTG GGGGTGTTAT ACTGAGCAGC AGCGTTGTGA TGGGTATTGG 
CATTGCCCAA ATGGAAGGGA TGAAACCAAT TGTACCATGT GCCAGAAGGA AGAATTTCCA 
TGTTCCCGAA ATGGTGTCTG TTATCCTCGT TCTGATCGCT GCAACTACCA GAATCATTGC 
CCAAATGGCT CAGATGAAAA AAACTGCTTT TTTTGCCAAC CAGGAAATTT CCATTGTAAA 
AACAATCGTT GTGTGTTTGA AAGTTGGGTG TGTGATTCTC AAGATGACTG TGGTGATGGC 
AGCGATGAAG AAAATTGCCC AGTAATCGTG CCTACAAGAG TCATCACTGC TGCCGTCATA 
GGGAGCCTCA TCTGTGGCCT GTTACTCGTC ATAGCATTGG GATGTACTTG TAAGCTTTAT 
TCTCTGAGAA TGTTTGAAAG AAGATCATTT GAAACACAGT TGTCAAGAGT GGAAGCAGAA 
TTGTTAAGAA GAGAAGCTCC TCCCTCGTAT GGACAATTGA TTGCTCAGGG TTTAATTCCA 
CCAGTTGAAG ATTTTCCTGT TTGTTCACCT AATCAGGCTT CTGTTTTGGA AAATCTGAGG 
CTAGCGGTAC GATCTCAGCT TGGATTTACT TCAGTCAGGC TTCCTATGGC AGGCAGATCA 
AGCAACATTT GGAACCGTAT TTTTAATTTT GCAAGATCAC GTCATTCTGG GTCATTGGCT 
TTGGTCTCAG CAGATGGAGA TGAGGTTGTC CCTAGTCAGA GTACCAGTAG AGAACCTGAG 
AGAAATCATA CTCACAGAAG TTTGTTTTCC GTGGAGTCTG ATGATACAGA CACAGAAAAT 
GAGAGAAGAG ATATGGCAGG AGCATCTGGT GGGGTTGCAG CTCCTTTGCC TCAAAAAGTC 
CCTCCCACAA CGGCAGTAGA AGCGACAGTA GGAGCATGTG CAAGTTCCTC AACTCAGAGT 
ACCCGAGGTG GTCATGCAGA TAATGGAAGG GATGTGACAA GTGTGGAACC CCCAAGTGTG 
AGTCCAGCAC GTCACCAGCT TACAAGTGCA CTCAGTCGTA TGACTCAGGG GCTACGCTGG 
GTACGTTTTA CATTAGGACG ATCAAGTTCC CTAAGTCAGA ACCAGAGTCC TTTGAGACAA 
CTTGATAATG GGGTAAGTGG AAGAGAAGAT GATGATGATG TTGAAATGCT AATTCCAATT 
TCTGATGGAT CTTCAGACTT TGATGTGAAT GACTGCTCCA GACCTCTTCT TGATCTTGCC 
TCAGATCAAG GACAAGGGCT TAGACAACCA TATAATGCAA CAAATCCTGG AGTAAGGCCA 
AGTAATCGAG ATGGCCCCTG TGAGCGCTGT GGTATTGTCC ACACTGCCCA GATACCAGAC 
ACTTGCTTAG AAGTAACACT GAAAAACGAA ACGAGTGATG ATGAGGCTTT GTTACTTTGT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LRP12 ( NM_013437.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_038465.1 Homo sapiens LDL receptor related protein 12 (LRP12), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12752
Clone ID Related Accession (Same CDS sequence)	NM_013437.4
Accession Version	NM_013437.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2580bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1556553600000
Organism	Homo sapiens(human)
Product	low-density lipoprotein receptor-related protein 12 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC372924.1, AC090827.11, BC032109.2, AB208957.1 and AI828757.1. On Feb 18, 2010 this sequence version replaced NM_013437.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: SRR1803615.230651.1, SRR1660805.245076.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCTGTC GCTGGAGCAC AAAAGAGTCT CCGCGGTGGA GGTCTGCGTT GCTCTTGCTT 
TTCCTCGCTG GGGTGTACGG AAATGGTGCT CTTGCAGAAC ATTCTGAAAA TGTGCATATT 
TCAGGAGTGT CAACTGCTTG TGGAGAGACT CCAGAGCAAA TACGAGCACC AAGTGGCATA 
ATCACAAGCC CAGGCTGGCC TTCTGAATAT CCTGCAAAAA TCAACTGTAG CTGGTTCATA 
AGGGCAAACC CAGGCGAAAT CATTACTATA AGTTTTCAGG ATTTTGATAT TCAAGGATCC 
AGAAGGTGCA ATTTGGACTG GTTGACAATA GAAACATACA AGAATATTGA AAGTTACAGA 
GCTTGTGGTT CCACAATTCC ACCTCCGTAT ATCTCTTCAC AAGACCACAT CTGGATTAGG 
TTTCATTCGG ATGACAACAT CTCTAGAAAG GGTTTCAGAC TGGCATATTT TTCAGGGAAA 
TCTGAGGAAC CAAATTGTGC TTGTGATCAG TTTCGTTGTG GTAATGGAAA GTGTATACCA 
GAAGCCTGGA AATGTAATAA CATGGATGAA TGTGGAGATA GTTCCGATGA AGAGATCTGT 
GCCAAAGAAG CAAATCCTCC AACTGCTGCT GCTTTTCAAC CCTGTGCTTA CAACCAGTTC 
CAGTGTTTAT CCCGTTTTAC CAAAGTTTAC ACTTGCCTCC CCGAATCTTT AAAATGTGAT 
GGGAACATTG ACTGCCTTGA CCTAGGAGAT GAGATAGACT GTGATGTGCC AACATGTGGG 
CAATGGCTAA AATATTTTTA TGGTACTTTT AATTCTCCCA ATTATCCAGA CTTTTATCCT 
CCTGGAAGCA ATTGCACCTG GTTAATAGAC ACTGGTGATC ACCGTAAAGT CATTTTACGC 
TTCACTGACT TTAAACTTGA TGGTACTGGT TATGGTGATT ATGTCAAAAT ATATGATGGA 
TTAGAGGAGA ATCCACACAA GCTTTTGCGT GTGTTGACAG CTTTTGATTC TCATGCACCT 
CTTACAGTTG TTTCTTCTTC TGGACAGATA AGGGTACATT TTTGTGCTGA TAAAGTGAAT 
GCTGCAAGGG GATTTAATGC TACTTACCAA GTAGATGGGT TCTGTTTGCC ATGGGAAATA 
CCCTGTGGAG GTAACTGGGG GTGTTATACT GAGCAGCAGC GTTGTGATGG GTATTGGCAT 
TGCCCAAATG GAAGGGATGA AACCAATTGT ACCATGTGCC AGAAGGAAGA ATTTCCATGT 
TCCCGAAATG GTGTCTGTTA TCCTCGTTCT GATCGCTGCA ACTACCAGAA TCATTGCCCA 
AATGGCTCAG ATGAAAAAAA CTGCTTTTTT TGCCAACCAG GAAATTTCCA TTGTAAAAAC 
AATCGTTGTG TGTTTGAAAG TTGGGTGTGT GATTCTCAAG ATGACTGTGG TGATGGCAGC 
GATGAAGAAA ATTGCCCAGT AATCGTGCCT ACAAGAGTCA TCACTGCTGC CGTCATAGGG 
AGCCTCATCT GTGGCCTGTT ACTCGTCATA GCATTGGGAT GTACTTGTAA GCTTTATTCT 
CTGAGAATGT TTGAAAGAAG ATCATTTGAA ACACAGTTGT CAAGAGTGGA AGCAGAATTG 
TTAAGAAGAG AAGCTCCTCC CTCGTATGGA CAATTGATTG CTCAGGGTTT AATTCCACCA 
GTTGAAGATT TTCCTGTTTG TTCACCTAAT CAGGCTTCTG TTTTGGAAAA TCTGAGGCTA 
GCGGTACGAT CTCAGCTTGG ATTTACTTCA GTCAGGCTTC CTATGGCAGG CAGATCAAGC 
AACATTTGGA ACCGTATTTT TAATTTTGCA AGATCACGTC ATTCTGGGTC ATTGGCTTTG 
GTCTCAGCAG ATGGAGATGA GGTTGTCCCT AGTCAGAGTA CCAGTAGAGA ACCTGAGAGA 
AATCATACTC ACAGAAGTTT GTTTTCCGTG GAGTCTGATG ATACAGACAC AGAAAATGAG 
AGAAGAGATA TGGCAGGAGC ATCTGGTGGG GTTGCAGCTC CTTTGCCTCA AAAAGTCCCT 
CCCACAACGG CAGTAGAAGC GACAGTAGGA GCATGTGCAA GTTCCTCAAC TCAGAGTACC 
CGAGGTGGTC ATGCAGATAA TGGAAGGGAT GTGACAAGTG TGGAACCCCC AAGTGTGAGT 
CCAGCACGTC ACCAGCTTAC AAGTGCACTC AGTCGTATGA CTCAGGGGCT ACGCTGGGTA 
CGTTTTACAT TAGGACGATC AAGTTCCCTA AGTCAGAACC AGAGTCCTTT GAGACAACTT 
GATAATGGGG TAAGTGGAAG AGAAGATGAT GATGATGTTG AAATGCTAAT TCCAATTTCT 
GATGGATCTT CAGACTTTGA TGTGAATGAC TGCTCCAGAC CTCTTCTTGA TCTTGCCTCA 
GATCAAGGAC AAGGGCTTAG ACAACCATAT AATGCAACAA ATCCTGGAGT AAGGCCAAGT 
AATCGAGATG GCCCCTGTGA GCGCTGTGGT ATTGTCCACA CTGCCCAGAT ACCAGACACT 
TGCTTAGAAG TAACACTGAA AAACGAAACG AGTGATGATG AGGCTTTGTT ACTTTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038465.1
CDS	128..2707
Translation	MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEALLLC

Target ORF information:

RefSeq Version	NM_013437.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LDL receptor related protein 12 (LRP12), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013437.4

ORF Insert Sequence:

ATGGCCTGTC GCTGGAGCAC AAAAGAGTCT CCGCGGTGGA GGTCTGCGTT GCTCTTGCTT 
TTCCTCGCTG GGGTGTACGG AAATGGTGCT CTTGCAGAAC ATTCTGAAAA TGTGCATATT 
TCAGGAGTGT CAACTGCTTG TGGAGAGACT CCAGAGCAAA TACGAGCACC AAGTGGCATA 
ATCACAAGCC CAGGCTGGCC TTCTGAATAT CCTGCAAAAA TCAACTGTAG CTGGTTCATA 
AGGGCAAACC CAGGCGAAAT CATTACTATA AGTTTTCAGG ATTTTGATAT TCAAGGATCC 
AGAAGGTGCA ATTTGGACTG GTTGACAATA GAAACATACA AGAATATTGA AAGTTACAGA 
GCTTGTGGTT CCACAATTCC ACCTCCGTAT ATCTCTTCAC AAGACCACAT CTGGATTAGG 
TTTCATTCGG ATGACAACAT CTCTAGAAAG GGTTTCAGAC TGGCATATTT TTCAGGGAAA 
TCTGAGGAAC CAAATTGTGC TTGTGATCAG TTTCGTTGTG GTAATGGAAA GTGTATACCA 
GAAGCCTGGA AATGTAATAA CATGGATGAA TGTGGAGATA GTTCCGATGA AGAGATCTGT 
GCCAAAGAAG CAAATCCTCC AACTGCTGCT GCTTTTCAAC CCTGTGCTTA CAACCAGTTC 
CAGTGTTTAT CCCGTTTTAC CAAAGTTTAC ACTTGCCTCC CCGAATCTTT AAAATGTGAT 
GGGAACATTG ACTGCCTTGA CCTAGGAGAT GAGATAGACT GTGATGTGCC AACATGTGGG 
CAATGGCTAA AATATTTTTA TGGTACTTTT AATTCTCCCA ATTATCCAGA CTTTTATCCT 
CCTGGAAGCA ATTGCACCTG GTTAATAGAC ACTGGTGATC ACCGTAAAGT CATTTTACGC 
TTCACTGACT TTAAACTTGA TGGTACTGGT TATGGTGATT ATGTCAAAAT ATATGATGGA 
TTAGAGGAGA ATCCACACAA GCTTTTGCGT GTGTTGACAG CTTTTGATTC TCATGCACCT 
CTTACAGTTG TTTCTTCTTC TGGACAGATA AGGGTACATT TTTGTGCTGA TAAAGTGAAT 
GCTGCAAGGG GATTTAATGC TACTTACCAA GTAGATGGGT TCTGTTTGCC ATGGGAAATA 
CCCTGTGGAG GTAACTGGGG GTGTTATACT GAGCAGCAGC GTTGTGATGG GTATTGGCAT 
TGCCCAAATG GAAGGGATGA AACCAATTGT ACCATGTGCC AGAAGGAAGA ATTTCCATGT 
TCCCGAAATG GTGTCTGTTA TCCTCGTTCT GATCGCTGCA ACTACCAGAA TCATTGCCCA 
AATGGCTCAG ATGAAAAAAA CTGCTTTTTT TGCCAACCAG GAAATTTCCA TTGTAAAAAC 
AATCGTTGTG TGTTTGAAAG TTGGGTGTGT GATTCTCAAG ATGACTGTGG TGATGGCAGC 
GATGAAGAAA ATTGCCCAGT AATCGTGCCT ACAAGAGTCA TCACTGCTGC CGTCATAGGG 
AGCCTCATCT GTGGCCTGTT ACTCGTCATA GCATTGGGAT GTACTTGTAA GCTTTATTCT 
CTGAGAATGT TTGAAAGAAG ATCATTTGAA ACACAGTTGT CAAGAGTGGA AGCAGAATTG 
TTAAGAAGAG AAGCTCCTCC CTCGTATGGA CAATTGATTG CTCAGGGTTT AATTCCACCA 
GTTGAAGATT TTCCTGTTTG TTCACCTAAT CAGGCTTCTG TTTTGGAAAA TCTGAGGCTA 
GCGGTACGAT CTCAGCTTGG ATTTACTTCA GTCAGGCTTC CTATGGCAGG CAGATCAAGC 
AACATTTGGA ACCGTATTTT TAATTTTGCA AGATCACGTC ATTCTGGGTC ATTGGCTTTG 
GTCTCAGCAG ATGGAGATGA GGTTGTCCCT AGTCAGAGTA CCAGTAGAGA ACCTGAGAGA 
AATCATACTC ACAGAAGTTT GTTTTCCGTG GAGTCTGATG ATACAGACAC AGAAAATGAG 
AGAAGAGATA TGGCAGGAGC ATCTGGTGGG GTTGCAGCTC CTTTGCCTCA AAAAGTCCCT 
CCCACAACGG CAGTAGAAGC GACAGTAGGA GCATGTGCAA GTTCCTCAAC TCAGAGTACC 
CGAGGTGGTC ATGCAGATAA TGGAAGGGAT GTGACAAGTG TGGAACCCCC AAGTGTGAGT 
CCAGCACGTC ACCAGCTTAC AAGTGCACTC AGTCGTATGA CTCAGGGGCT ACGCTGGGTA 
CGTTTTACAT TAGGACGATC AAGTTCCCTA AGTCAGAACC AGAGTCCTTT GAGACAACTT 
GATAATGGGG TAAGTGGAAG AGAAGATGAT GATGATGTTG AAATGCTAAT TCCAATTTCT 
GATGGATCTT CAGACTTTGA TGTGAATGAC TGCTCCAGAC CTCTTCTTGA TCTTGCCTCA 
GATCAAGGAC AAGGGCTTAG ACAACCATAT AATGCAACAA ATCCTGGAGT AAGGCCAAGT 
AATCGAGATG GCCCCTGTGA GCGCTGTGGT ATTGTCCACA CTGCCCAGAT ACCAGACACT 
TGCTTAGAAG TAACACTGAA AAACGAAACG AGTGATGATG AGGCTTTGTT ACTTTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance.
Genome medicine10(1)55(2018 07)
Grasse S,Lienhard M,Frese S,Kerick M,Steinbach A,Grimm C,Hussong M,Rolff J,Becker M,Dreher F,Schirmer U,Boerno S,Ramisch A,Leschber G,Timmermann B,Grohé C,Lüders H,Vingron M,Fichtner I,Klein S,Odenthal M,Büttner R,Lehrach H,Sültmann H,Herwig R,Schweiger MR

Abundance of LRP12 C-rs9694676 allelic promoter variant in epilepsy-associated gangliogliomas.
Life sciences15570-5(2016 Jun)
Robens BK,Gembé E,Fassunke J,Becker AJ,Schoch S,Grote A

LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization.
Neurobiology of disease86170-6(2016 Feb)
Grote A,Robens BK,Blümcke I,Becker AJ,Schoch S,Gembé E

Genome-wide association study of chronic periodontitis in a general German population.
Journal of clinical periodontology40(11)977-85(2013 Nov)
Teumer A,Holtfreter B,Völker U,Petersmann A,Nauck M,Biffar R,Völzke H,Kroemer HK,Meisel P,Homuth G,Kocher T

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.
PLoS genetics8(4)e1002654(2012)
Wiggs JL,Yaspan BL,Hauser MA,Kang JH,Allingham RR,Olson LM,Abdrabou W,Fan BJ,Wang DY,Brodeur W,Budenz DL,Caprioli J,Crenshaw A,Crooks K,Delbono E,Doheny KF,Friedman DS,Gaasterland D,Gaasterland T,Laurie C,Lee RK,Lichter PR,Loomis S,Liu Y,Medeiros FA,McCarty C,Mirel D,Moroi SE,Musch DC,Realini A,Rozsa FW,Schuman JS,Scott K,Singh K,Stein JD,Trager EH,Vanveldhuisen P,Vollrath D,Wollstein G,Yoneyama S,Zhang K,Weinreb RN,Ernst J,Kellis M,Masuda T,Zack D,Richards JE,Pericak-Vance M,Pasquale LR,Haines JL

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LRP12 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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