BLOC1S2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BLOC1S2
Entrez Gene ID	282991
Full Name	biogenesis of lysosomal organelles complex 1 subunit 2
Synonyms	BLOS2,BORCS2,CEAP,CEAP11
General protein information	Preferred Names biogenesis of lysosomal organelles complex 1 subunit 2 Names biogenesis of lysosome-related organelles complex 1 subunit 2 11 kDa centrosome associated protein BLOC-1 subunit 2 centrosomal 10 kDa protein centrosome protein oncogene
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.31
Summary	This gene encodes a protein with multiple functions. The encoded protein has been found in association with the centrosome, shown to co-localize with gamma-tubulin, and also found to be one of the proteins in the BLOC-1 complex which functions in the formation of lysosome-related organelles. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
Disorder MIM:	609768

mRNA and Protein(s)

mRNA	Protein	Name
NM_173809.4	NP_776170.2	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1
NM_001282437.1	NP_001269366.1	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 2
NM_001001342.2	NP_001001342.1	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 2
NM_001282436.1	NP_001269365.1	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 3
NM_001282439.1	NP_001269368.1	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 4
XM_017016102.1	XP_016871591.1	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform X1
NM_001282438.1	NP_001269367.1	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 2
NM_173809.5	NP_776170.2	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	BLOC1S2	NP_776170.2
Rattus norvegicus (Norway rat)	Bloc1s2	NP_001032426.1
Danio rerio (zebrafish)	bloc1s2	NP_001231685.1
Macaca mulatta (Rhesus monkey)	BLOC1S2	XP_001107721.1
Xenopus tropicalis (tropical clawed frog)	bloc1s2	NP_001008201.1
Canis lupus familiaris (dog)	LOC612865	XP_851447.1
Bos taurus (cattle)	LOC519172	XP_002698474.1
Mus musculus (house mouse)	Bloc1s2	NP_082883.1
Gallus gallus (chicken)	BLOC1S2	NP_001264281.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

BORC, a multisubunit complex that regulates lysosome positioning.
Pu J, Schindler C, Jia R, Jarnik M, Backlund P, Bonifacino JS
Developmental cell33(2)176-88(2015 Apr)

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Blandin G, Marchand S, Charton K, Danièle N, Gicquel E, Boucheteil JB, Bentaib A, Barrault L, Stockholm D, Bartoli M, Richard I
Skeletal muscle3(1)3(2013 Feb)

Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
Lee HH, Nemecek D, Schindler C, Smith WJ, Ghirlando R, Steven AC, Bonifacino JS, Hurley JH
The Journal of biological chemistry287(8)5882-90(2012 Feb)

Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.
Monfregola J, Napolitano G, D'Urso M, Lappalainen P, Ursini MV
The Journal of biological chemistry285(22)16951-7(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following BLOC1S2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BLOC1S2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12950	NM_001282439.1 Latest version!	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu15346	NM_001282436.1 Latest version!	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu91313	XM_017016102.1 Latest version!	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu15078	NM_001282438.1 Latest version!	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu15078	NM_001001342.2 Latest version!	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu15078	NM_001282437.1 Latest version!	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu15217	NM_173809.5 Latest version!	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu15217	NM_173809.4	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BLOC1S2 ( NM_001282439.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269368.1 Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 6, mRNA.

Price & Availability↑

CloneID	OHu12950
Clone ID Related Accession (Same CDS sequence)	NM_001282439.1
Accession Version	NM_001282439.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL139819.8, DB456773.1, BU608851.1, CB218039.1, DB296446.1, AL138921.14 and BX112121.1. Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.177145.1, SRR1163655.416714.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CAGCCGAGGG CGTACTGGCG ACCCGGAGTG ATGAGCCCGC CCGAGACGAT 
GCCGCCGTGG AGACAGCTGA GGAAGCAAAG GAGCCTGCTG AAGCTGACAT CACTGAGCTC 
TGCCGGGACA TGTTCTCCAA AATGGCCACT TACCTGACTG GGGAACTGAC GGCCACCAGT 
GAAGACTATA AGCTCCTGGA AAATATGAAT AAACTCACCA GCTTGAAGTA TCTTGAAATG 
AAAGATATTG CTATAAACAT TAGTAGGAAC TTAAAGGACT TAAACCAGAA ATATGCTGGA 
CTGCAGCCTT ATCTGGATCA GATCAATGTC ATTGAAGAGC AGGTAGCAGC TCTTGAGCAG 
GCAGCTTACA AGTTGGATGC ATATTCAAAA AAACTGGCCA AGTACAAGAA GCTGGAGAAG 
CGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269368.1
CDS	54..479
Translation	MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLAKYKKLEKR

Target ORF information:

RefSeq Version	NM_001282439.1
Organism	Homo sapiens(human)
Definition	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282439.1

ORF Insert Sequence:

ATGGCGGCGG CAGCCGAGGG CGTACTGGCG ACCCGGAGTG ATGAGCCCGC CCGAGACGAT 
GCCGCCGTGG AGACAGCTGA GGAAGCAAAG GAGCCTGCTG AAGCTGACAT CACTGAGCTC 
TGCCGGGACA TGTTCTCCAA AATGGCCACT TACCTGACTG GGGAACTGAC GGCCACCAGT 
GAAGACTATA AGCTCCTGGA AAATATGAAT AAACTCACCA GCTTGAAGTA TCTTGAAATG 
AAAGATATTG CTATAAACAT TAGTAGGAAC TTAAAGGACT TAAACCAGAA ATATGCTGGA 
CTGCAGCCTT ATCTGGATCA GATCAATGTC ATTGAAGAGC AGGTAGCAGC TCTTGAGCAG 
GCAGCTTACA AGTTGGATGC ATATTCAAAA AAACTGGCCA AGTACAAGAA GCTGGAGAAG 
CGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BLOC1S2 ( NM_001282436.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269365.1 Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu15346
Clone ID Related Accession (Same CDS sequence)	NM_001282436.1
Accession Version	NM_001282436.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB118026.1, BF666010.1, AL139819.8, AL138921.14 and BX112121.1. On Sep 6, 2013 this sequence version replaced NR_046314.1. Transcript Variant: This variant (3) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (3) with a shorter and distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.341889.1, SRR1163655.161282.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGATTGC CAAGGAAGAG CTTAGAAGTA GCCACCAGTG AAGACTATAA GCTCCTGGAA 
AATATGAATA AACTCACCAG CTTGAAGTAT CTTGAAATGA AAGATATTGC TATAAACATT 
AGTAGGAACT TAAAGGACTT AAACCAGAAA TATGCTGGAC TGCAGCCTTA TCTGGATCAG 
ATCAATGTCA TTGAAGAGCA GGTAGCAGCT CTTGAGCAGG CAGCTTACAA GTTGGATGCA 
TATTCAAAAA AACTGGAAGC CAAGTACAAG AAGCTGGAGA AGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269365.1
CDS	303..590
Translation	MRLPRKSLEVATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR

Target ORF information:

RefSeq Version	NM_001282436.1
Organism	Homo sapiens(human)
Definition	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282436.1

ORF Insert Sequence:

ATGAGATTGC CAAGGAAGAG CTTAGAAGTA GCCACCAGTG AAGACTATAA GCTCCTGGAA 
AATATGAATA AACTCACCAG CTTGAAGTAT CTTGAAATGA AAGATATTGC TATAAACATT 
AGTAGGAACT TAAAGGACTT AAACCAGAAA TATGCTGGAC TGCAGCCTTA TCTGGATCAG 
ATCAATGTCA TTGAAGAGCA GGTAGCAGCT CTTGAGCAGG CAGCTTACAA GTTGGATGCA 
TATTCAAAAA AACTGGAAGC CAAGTACAAG AAGCTGGAGA AGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BLOC1S2 ( XM_017016102.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016871591.1 Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu91313
Clone ID Related Accession (Same CDS sequence)	XM_017016102.1
Accession Version	XM_017016102.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCTCCA AAATGGCCAC TTACCTGACT GGGGAACTGA CGGCCACCAG TGAAGACTAT 
AAGCTCCTGG AAAATATGAA TAAACTCACC AGCTTGAAGT ATCTTGAAAT GAAAGATATT 
GCTATAAACA TTAGTAGGAA CTTAAAGGAC TTAAACCAGA AATATGCTGG ACTGCAGCCT 
TATCTGGATC AGATCAATGT CATTGAAGAG CAGGTAGCAG CTCTTGAGCA GGCAGCTTAC 
AAGTTGGATG CATATTCAAA AAAACTGGGT AACCGTTTTT ACTTCTGTTT TGATGTAATA 
AAGACTGCTT CTTGCCAGCA TATTCTTAGT AAACATAATA GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016871591.1
CDS	282..626
Translation	MFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLGNRFYFCFDVIKTASCQHILSKHNS

Target ORF information:

RefSeq Version	XM_017016102.1
Organism	Homo sapiens(human)
Definition	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017016102.1

ORF Insert Sequence:

ATGTTCTCCA AAATGGCCAC TTACCTGACT GGGGAACTGA CGGCCACCAG TGAAGACTAT 
AAGCTCCTGG AAAATATGAA TAAACTCACC AGCTTGAAGT ATCTTGAAAT GAAAGATATT 
GCTATAAACA TTAGTAGGAA CTTAAAGGAC TTAAACCAGA AATATGCTGG ACTGCAGCCT 
TATCTGGATC AGATCAATGT CATTGAAGAG CAGGTAGCAG CTCTTGAGCA GGCAGCTTAC 
AAGTTGGATG CATATTCAAA AAAACTGGGT AACCGTTTTT ACTTCTGTTT TGATGTAATA 
AAGACTGCTT CTTGCCAGCA TATTCTTAGT AAACATAATA GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BLOC1S2 ( NM_001282437.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269366.1 Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu15078
Clone ID Related Accession (Same CDS sequence)	NM_001282437.1 , NM_001001342.2 , NM_001282438.1
Accession Version	NM_001282437.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB118026.1, CN340962.1, AL138921.14 and BX112121.1. On Sep 6, 2013 this sequence version replaced NR_046315.1. Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2, 4, and 5 encode the same isoform (2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.109467.1, SRR1803615.21294.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142348, SAMEA2146236 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCTCCA AAATGGCCAC TTACCTGACT GGGGAACTGA CGGCCACCAG TGAAGACTAT 
AAGCTCCTGG AAAATATGAA TAAACTCACC AGCTTGAAGT ATCTTGAAAT GAAAGATATT 
GCTATAAACA TTAGTAGGAA CTTAAAGGAC TTAAACCAGA AATATGCTGG ACTGCAGCCT 
TATCTGGATC AGATCAATGT CATTGAAGAG CAGGTAGCAG CTCTTGAGCA GGCAGCTTAC 
AAGTTGGATG CATATTCAAA AAAACTGGAA GCCAAGTACA AGAAGCTGGA GAAGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269366.1
CDS	302..601
Translation	MFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR

Target ORF information:

RefSeq Version	NM_001282437.1
Organism	Homo sapiens(human)
Definition	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282437.1

ORF Insert Sequence:

ATGTTCTCCA AAATGGCCAC TTACCTGACT GGGGAACTGA CGGCCACCAG TGAAGACTAT 
AAGCTCCTGG AAAATATGAA TAAACTCACC AGCTTGAAGT ATCTTGAAAT GAAAGATATT 
GCTATAAACA TTAGTAGGAA CTTAAAGGAC TTAAACCAGA AATATGCTGG ACTGCAGCCT 
TATCTGGATC AGATCAATGT CATTGAAGAG CAGGTAGCAG CTCTTGAGCA GGCAGCTTAC 
AAGTTGGATG CATATTCAAA AAAACTGGAA GCCAAGTACA AGAAGCTGGA GAAGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BLOC1S2 ( NM_001001342.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001342.1 Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu15078
Clone ID Related Accession (Same CDS sequence)	NM_001282437.1 , NM_001001342.2 , NM_001282438.1
Accession Version	NM_001001342.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY107885.1, AK054697.1, AL138921.14 and BX112121.1. On or before Sep 6, 2013 this sequence version replaced NR_046296.2, NM_001001342.1. Transcript Variant: This variant (2) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2, 4, and 5 encode the same isoform (2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.100310.1, SRR1660807.3839.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142348, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCTCCA AAATGGCCAC TTACCTGACT GGGGAACTGA CGGCCACCAG TGAAGACTAT 
AAGCTCCTGG AAAATATGAA TAAACTCACC AGCTTGAAGT ATCTTGAAAT GAAAGATATT 
GCTATAAACA TTAGTAGGAA CTTAAAGGAC TTAAACCAGA AATATGCTGG ACTGCAGCCT 
TATCTGGATC AGATCAATGT CATTGAAGAG CAGGTAGCAG CTCTTGAGCA GGCAGCTTAC 
AAGTTGGATG CATATTCAAA AAAACTGGAA GCCAAGTACA AGAAGCTGGA GAAGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001342.1
CDS	226..525
Translation	MFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR

Target ORF information:

RefSeq Version	NM_001001342.2
Organism	Homo sapiens(human)
Definition	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001342.2

ORF Insert Sequence:

ATGTTCTCCA AAATGGCCAC TTACCTGACT GGGGAACTGA CGGCCACCAG TGAAGACTAT 
AAGCTCCTGG AAAATATGAA TAAACTCACC AGCTTGAAGT ATCTTGAAAT GAAAGATATT 
GCTATAAACA TTAGTAGGAA CTTAAAGGAC TTAAACCAGA AATATGCTGG ACTGCAGCCT 
TATCTGGATC AGATCAATGT CATTGAAGAG CAGGTAGCAG CTCTTGAGCA GGCAGCTTAC 
AAGTTGGATG CATATTCAAA AAAACTGGAA GCCAAGTACA AGAAGCTGGA GAAGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BLOC1S2 ( NM_001282438.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269367.1 Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu15078
Clone ID Related Accession (Same CDS sequence)	NM_001282437.1 , NM_001001342.2 , NM_001282438.1
Accession Version	NM_001282438.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY165508.1, BU740315.1, CB218039.1, DB296446.1, AL138921.14 and BX112121.1. Transcript Variant: This variant (5) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2, 4, and 5 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY164345.1, HY165508.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142348, SAMEA2146236 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCTCCA AAATGGCCAC TTACCTGACT GGGGAACTGA CGGCCACCAG TGAAGACTAT 
AAGCTCCTGG AAAATATGAA TAAACTCACC AGCTTGAAGT ATCTTGAAAT GAAAGATATT 
GCTATAAACA TTAGTAGGAA CTTAAAGGAC TTAAACCAGA AATATGCTGG ACTGCAGCCT 
TATCTGGATC AGATCAATGT CATTGAAGAG CAGGTAGCAG CTCTTGAGCA GGCAGCTTAC 
AAGTTGGATG CATATTCAAA AAAACTGGAA GCCAAGTACA AGAAGCTGGA GAAGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269367.1
CDS	153..452
Translation	MFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR

Target ORF information:

RefSeq Version	NM_001282438.1
Organism	Homo sapiens(human)
Definition	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282438.1

ORF Insert Sequence:

ATGTTCTCCA AAATGGCCAC TTACCTGACT GGGGAACTGA CGGCCACCAG TGAAGACTAT 
AAGCTCCTGG AAAATATGAA TAAACTCACC AGCTTGAAGT ATCTTGAAAT GAAAGATATT 
GCTATAAACA TTAGTAGGAA CTTAAAGGAC TTAAACCAGA AATATGCTGG ACTGCAGCCT 
TATCTGGATC AGATCAATGT CATTGAAGAG CAGGTAGCAG CTCTTGAGCA GGCAGCTTAC 
AAGTTGGATG CATATTCAAA AAAACTGGAA GCCAAGTACA AGAAGCTGGA GAAGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BLOC1S2 ( NM_173809.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_776170.2 Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15217
Clone ID Related Accession (Same CDS sequence)	NM_173809.4 , NM_173809.5
Accession Version	NM_173809.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB118026.1, AK298969.1, AL138921.14 and BX112121.1. On Feb 9, 2012 this sequence version replaced NM_173809.3. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.1861.1, SRR1803617.119002.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142348, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CAGCCGAGGG CGTACTGGCG ACCCGGAGTG ATGAGCCCGC CCGAGACGAT 
GCCGCCGTGG AGACAGCTGA GGAAGCAAAG GAGCCTGCTG AAGCTGACAT CACTGAGCTC 
TGCCGGGACA TGTTCTCCAA AATGGCCACT TACCTGACTG GGGAACTGAC GGCCACCAGT 
GAAGACTATA AGCTCCTGGA AAATATGAAT AAACTCACCA GCTTGAAGTA TCTTGAAATG 
AAAGATATTG CTATAAACAT TAGTAGGAAC TTAAAGGACT TAAACCAGAA ATATGCTGGA 
CTGCAGCCTT ATCTGGATCA GATCAATGTC ATTGAAGAGC AGGTAGCAGC TCTTGAGCAG 
GCAGCTTACA AGTTGGATGC ATATTCAAAA AAACTGGAAG CCAAGTACAA GAAGCTGGAG 
AAGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776170.2
CDS	54..482
Translation	MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR

Target ORF information:

RefSeq Version	NM_173809.4
Organism	Homo sapiens(human)
Definition	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173809.4

ORF Insert Sequence:

ATGGCGGCGG CAGCCGAGGG CGTACTGGCG ACCCGGAGTG ATGAGCCCGC CCGAGACGAT 
GCCGCCGTGG AGACAGCTGA GGAAGCAAAG GAGCCTGCTG AAGCTGACAT CACTGAGCTC 
TGCCGGGACA TGTTCTCCAA AATGGCCACT TACCTGACTG GGGAACTGAC GGCCACCAGT 
GAAGACTATA AGCTCCTGGA AAATATGAAT AAACTCACCA GCTTGAAGTA TCTTGAAATG 
AAAGATATTG CTATAAACAT TAGTAGGAAC TTAAAGGACT TAAACCAGAA ATATGCTGGA 
CTGCAGCCTT ATCTGGATCA GATCAATGTC ATTGAAGAGC AGGTAGCAGC TCTTGAGCAG 
GCAGCTTACA AGTTGGATGC ATATTCAAAA AAACTGGAAG CCAAGTACAA GAAGCTGGAG 
AAGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BLOC1S2 ( NM_173809.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_776170.2 Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15217
Clone ID Related Accession (Same CDS sequence)	NM_173809.4 , NM_173809.5
Accession Version	NM_173809.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB118026.1, AK298969.1, AL138921.14 and BX112121.1. On Nov 22, 2018 this sequence version replaced NM_173809.4. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.480815.1, SRR1660809.185245.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142348, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370372.7/ ENSP00000359398.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGG CAGCCGAGGG CGTACTGGCG ACCCGGAGTG ATGAGCCCGC CCGAGACGAT 
GCCGCCGTGG AGACAGCTGA GGAAGCAAAG GAGCCTGCTG AAGCTGACAT CACTGAGCTC 
TGCCGGGACA TGTTCTCCAA AATGGCCACT TACCTGACTG GGGAACTGAC GGCCACCAGT 
GAAGACTATA AGCTCCTGGA AAATATGAAT AAACTCACCA GCTTGAAGTA TCTTGAAATG 
AAAGATATTG CTATAAACAT TAGTAGGAAC TTAAAGGACT TAAACCAGAA ATATGCTGGA 
CTGCAGCCTT ATCTGGATCA GATCAATGTC ATTGAAGAGC AGGTAGCAGC TCTTGAGCAG 
GCAGCTTACA AGTTGGATGC ATATTCAAAA AAACTGGAAG CCAAGTACAA GAAGCTGGAG 
AAGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776170.2
CDS	22..450
Translation	MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR

Target ORF information:

RefSeq Version	NM_173809.5
Organism	Homo sapiens(human)
Definition	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 2 (BLOC1S2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173809.5

ORF Insert Sequence:

ATGGCGGCGG CAGCCGAGGG CGTACTGGCG ACCCGGAGTG ATGAGCCCGC CCGAGACGAT 
GCCGCCGTGG AGACAGCTGA GGAAGCAAAG GAGCCTGCTG AAGCTGACAT CACTGAGCTC 
TGCCGGGACA TGTTCTCCAA AATGGCCACT TACCTGACTG GGGAACTGAC GGCCACCAGT 
GAAGACTATA AGCTCCTGGA AAATATGAAT AAACTCACCA GCTTGAAGTA TCTTGAAATG 
AAAGATATTG CTATAAACAT TAGTAGGAAC TTAAAGGACT TAAACCAGAA ATATGCTGGA 
CTGCAGCCTT ATCTGGATCA GATCAATGTC ATTGAAGAGC AGGTAGCAGC TCTTGAGCAG 
GCAGCTTACA AGTTGGATGC ATATTCAAAA AAACTGGAAG CCAAGTACAA GAAGCTGGAG 
AAGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

BORC, a multisubunit complex that regulates lysosome positioning.
Developmental cell33(2)176-88(2015 Apr)
Pu J,Schindler C,Jia R,Jarnik M,Backlund P,Bonifacino JS

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Skeletal muscle3(1)3(2013 Feb)
Blandin G,Marchand S,Charton K,Danièle N,Gicquel E,Boucheteil JB,Bentaib A,Barrault L,Stockholm D,Bartoli M,Richard I

Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
The Journal of biological chemistry287(8)5882-90(2012 Feb)
Lee HH,Nemecek D,Schindler C,Smith WJ,Ghirlando R,Steven AC,Bonifacino JS,Hurley JH

Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.
The Journal of biological chemistry285(22)16951-7(2010 May)
Monfregola J,Napolitano G,D'Urso M,Lappalainen P,Ursini MV

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BLOC1S2 cDNA ORF clone, Homo sapiens(human)

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