TXN2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TXN2
Entrez Gene ID	25828
Full Name	thioredoxin 2
Synonyms	COXPD29,MT-TRX,MTRX,TRX2,TXN
General protein information	Preferred Names thioredoxin 2 Names thioredoxin, mitochondrial mitochondrial thioredoxin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q12.3
Summary	This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008].
Disorder MIM:	609063
Disorder Html:	?Combined oxidative phosphorylation deficiency 29, 616811 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_012473.3	NP_036605.2	thioredoxin, mitochondrial precursor
NM_012473.4	NP_036605.2	thioredoxin, mitochondrial precursor
XM_005261508.1	XP_005261565.1	thioredoxin, mitochondrial isoform X1
XM_011530111.2	XP_011528413.1	thioredoxin, mitochondrial isoform X3
XM_006724226.1	XP_006724289.1	thioredoxin, mitochondrial isoform X2
XM_011530111.3	XP_011528413.1	thioredoxin, mitochondrial isoform X3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Txn2	NP_064297.1
Anopheles gambiae (African malaria mosquito)	TRX2	XP_308583.2
Homo sapiens (human)	TXN2	NP_036605.2
Bos taurus (cattle)	TXN2	NP_776633.1
Rattus norvegicus (Norway rat)	Txn2	NP_445783.1
Gallus gallus (chicken)	TXN2	NP_001026581.1
Danio rerio (zebrafish)	txn2	NP_991204.1
Drosophila melanogaster (fruit fly)	CG8993	NP_647716.1
Caenorhabditis elegans (roundworm)	trx-2	NP_001256207.1
Canis lupus familiaris (dog)	TXN2	XP_531748.3
Xenopus tropicalis (tropical clawed frog)	txn2	NP_001008161.1

Gene Ontology
Bibliography

Related articles in PubMed

Thioredoxin 2 Offers Protection against Mitochondrial Oxidative Stress in H9c2 Cells and against Myocardial Hypertrophy Induced by Hyperglycemia.
Li H, Xu C, Li Q, Gao X, Sugano E, Tomita H, Yang L, Shi S
International journal of molecular sciences18(9)(2017 Sep)

MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2.
Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Mizuguchi H
Journal of virology91(12)(2017 06)

Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension.
Adesina SE, Wade BE, Bijli KM, Kang BY, Williams CR, Ma J, Go YM, Hart CM, Sutliff RL
American journal of physiology. Lung cellular and molecular physiology312(5)L599-L608(2017 05)

Detoxification of Mitochondrial Oxidants and Apoptotic Signaling Are Facilitated by Thioredoxin-2 and Peroxiredoxin-3 during Hyperoxic Injury.
Forred BJ, Daugaard DR, Titus BK, Wood RR, Floen MJ, Booze ML, Vitiello PF
PloS one12(1)e0168777(2017)

Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus.
Ramus SM, Cilensek I, Petrovic MG, Soucek M, Kruzliak P, Petrovic D
Journal of diabetes and its complications30(2)192-8(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TXN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TXN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu53538	XM_005261508.1 Latest version!	Homo sapiens thioredoxin 2 (TXN2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu66511	XM_011530111.3 Latest version!	Homo sapiens thioredoxin 2 (TXN2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu13707	NM_012473.4 Latest version!	Homo sapiens thioredoxin 2 (TXN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu13707	XM_006724226.1 Latest version!	Homo sapiens thioredoxin 2 (TXN2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu13707	NM_012473.3	Homo sapiens thioredoxin 2 (TXN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu66511	XM_011530111.2	Homo sapiens thioredoxin 2 (TXN2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TXN2 ( XM_005261508.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005261565.1 Homo sapiens thioredoxin 2 (TXN2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu53538
Clone ID Related Accession (Same CDS sequence)	XM_005261508.1
Accession Version	XM_005261508.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	thioredoxin, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACGTCC CCCCCCGAGG AAGTGACGAC AGGCGTGCCC TTGACAGGCA GGGAGGGCTA 
GGCTGTGCAT CCCTCCGCTC GCATTGCAGG GAGATGGCTC AGCGACTTCT TCTGAGGAGG 
TTCCTGGCCT CTGTCATCTC CAGGAAGCCC TCTCAGGGTC AGTGGCCACC CCTCACTTCC 
AGAGCCCTGC AGACCCCACA ATGCAGTCCT GGTGGCCTGA CTGTAACACC CAACCCAGCC 
CGGACAATAT ACACCACGAG GATCTCCTTG ACAACCTTTA ATATCCAGGA TGGACCTGAC 
TTTCAAGACC GAGTGGTCAA CAGTGAGACA CCAGTGGTTG TGGATTTCCA CGCACAGTGG 
TGTGGACCCT GCAAGATCCT GGGGCCGAGG TTAGAGAAGA TGGTGGCCAA GCAGCACGGG 
AAGGTGGTGA TGGCCAAGGT GGATATTGAT GACCACACAG ACCTCGCCAT TGAGTATGAG 
GTGTCAGCGG TGCCCACTGT GCTGGCCATG AAGAATGGGG ACGTGGTGGA CAAGTTTGTG 
GGCATCAAGG ATGAGGATCA GTTGGAGGCC TTCCTGAAGA AGCTGATTGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005261565.1
CDS	370..963
Translation	MYVPPRGSDDRRALDRQGGLGCASLRSHCREMAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG

Target ORF information:

RefSeq Version	XM_005261508.1
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin 2 (TXN2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005261508.1

ORF Insert Sequence:

ATGTACGTCC CCCCCCGAGG AAGTGACGAC AGGCGTGCCC TTGACAGGCA GGGAGGGCTA 
GGCTGTGCAT CCCTCCGCTC GCATTGCAGG GAGATGGCTC AGCGACTTCT TCTGAGGAGG 
TTCCTGGCCT CTGTCATCTC CAGGAAGCCC TCTCAGGGTC AGTGGCCACC CCTCACTTCC 
AGAGCCCTGC AGACCCCACA ATGCAGTCCT GGTGGCCTGA CTGTAACACC CAACCCAGCC 
CGGACAATAT ACACCACGAG GATCTCCTTG ACAACCTTTA ATATCCAGGA TGGACCTGAC 
TTTCAAGACC GAGTGGTCAA CAGTGAGACA CCAGTGGTTG TGGATTTCCA CGCACAGTGG 
TGTGGACCCT GCAAGATCCT GGGGCCGAGG TTAGAGAAGA TGGTGGCCAA GCAGCACGGG 
AAGGTGGTGA TGGCCAAGGT GGATATTGAT GACCACACAG ACCTCGCCAT TGAGTATGAG 
GTGTCAGCGG TGCCCACTGT GCTGGCCATG AAGAATGGGG ACGTGGTGGA CAAGTTTGTG 
GGCATCAAGG ATGAGGATCA GTTGGAGGCC TTCCTGAAGA AGCTGATTGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TXN2 ( XM_011530111.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011528413.1 Homo sapiens thioredoxin 2 (TXN2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu66511
Clone ID Related Accession (Same CDS sequence)	XM_011530111.2 , XM_011530111.3
Accession Version	XM_011530111.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	thioredoxin, mitochondrial isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011530111.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACGTCC CCCCCCGAGG AAGTGACGAC AGGCGTGCCC TTGACAGGCA GGGAGGGCTA 
GGCTGTGCAT CCCTCCGCTC GCATTGCAGG GAGATGGCTC AGCGACTTCT TCTGAGGAGG 
TTCCTGGCCT CTGTCATCTC CAGGAAGCCC TCTCAGGGTC AGTGGCCACC CCTCACTTCC 
AGAGCCCTGC AGACCCCACA ATGCAGTCCT GGTGGCCTGA CTGTAACACC CAACCCAGCC 
CGGACAATAT ACACCACGAG GATCTCCTTG ACAACCTTTA ATATCCAGGA TGGACCTGAC 
TTTCAAGACC GAGTGGTCAA CAGTGAGACA CCAGTGGTTG TGGATTTCCA CGCACAGTGT 
CAGCGGTGCC CACTGTGCTG GCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011528413.1
CDS	370..756
Translation	MYVPPRGSDDRRALDRQGGLGCASLRSHCREMAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQCQRCPLCWP

Target ORF information:

RefSeq Version	XM_011530111.2
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin 2 (TXN2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011530111.2

ORF Insert Sequence:

ATGTACGTCC CCCCCCGAGG AAGTGACGAC AGGCGTGCCC TTGACAGGCA GGGAGGGCTA 
GGCTGTGCAT CCCTCCGCTC GCATTGCAGG GAGATGGCTC AGCGACTTCT TCTGAGGAGG 
TTCCTGGCCT CTGTCATCTC CAGGAAGCCC TCTCAGGGTC AGTGGCCACC CCTCACTTCC 
AGAGCCCTGC AGACCCCACA ATGCAGTCCT GGTGGCCTGA CTGTAACACC CAACCCAGCC 
CGGACAATAT ACACCACGAG GATCTCCTTG ACAACCTTTA ATATCCAGGA TGGACCTGAC 
TTTCAAGACC GAGTGGTCAA CAGTGAGACA CCAGTGGTTG TGGATTTCCA CGCACAGTGT 
CAGCGGTGCC CACTGTGCTG GCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TXN2 ( XM_011530111.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011528413.1 Homo sapiens thioredoxin 2 (TXN2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu66511
Clone ID Related Accession (Same CDS sequence)	XM_011530111.2 , XM_011530111.3
Accession Version	XM_011530111.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	thioredoxin, mitochondrial isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011530111.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACGTCC CCCCCCGAGG AAGTGACGAC AGGCGTGCCC TTGACAGGCA GGGAGGGCTA 
GGCTGTGCAT CCCTCCGCTC GCATTGCAGG GAGATGGCTC AGCGACTTCT TCTGAGGAGG 
TTCCTGGCCT CTGTCATCTC CAGGAAGCCC TCTCAGGGTC AGTGGCCACC CCTCACTTCC 
AGAGCCCTGC AGACCCCACA ATGCAGTCCT GGTGGCCTGA CTGTAACACC CAACCCAGCC 
CGGACAATAT ACACCACGAG GATCTCCTTG ACAACCTTTA ATATCCAGGA TGGACCTGAC 
TTTCAAGACC GAGTGGTCAA CAGTGAGACA CCAGTGGTTG TGGATTTCCA CGCACAGTGT 
CAGCGGTGCC CACTGTGCTG GCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011528413.1
CDS	17..403
Translation	MYVPPRGSDDRRALDRQGGLGCASLRSHCREMAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQCQRCPLCWP

Target ORF information:

RefSeq Version	XM_011530111.3
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin 2 (TXN2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011530111.3

ORF Insert Sequence:

ATGTACGTCC CCCCCCGAGG AAGTGACGAC AGGCGTGCCC TTGACAGGCA GGGAGGGCTA 
GGCTGTGCAT CCCTCCGCTC GCATTGCAGG GAGATGGCTC AGCGACTTCT TCTGAGGAGG 
TTCCTGGCCT CTGTCATCTC CAGGAAGCCC TCTCAGGGTC AGTGGCCACC CCTCACTTCC 
AGAGCCCTGC AGACCCCACA ATGCAGTCCT GGTGGCCTGA CTGTAACACC CAACCCAGCC 
CGGACAATAT ACACCACGAG GATCTCCTTG ACAACCTTTA ATATCCAGGA TGGACCTGAC 
TTTCAAGACC GAGTGGTCAA CAGTGAGACA CCAGTGGTTG TGGATTTCCA CGCACAGTGT 
CAGCGGTGCC CACTGTGCTG GCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TXN2 ( NM_012473.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036605.2 Homo sapiens thioredoxin 2 (TXN2), mRNA.

Price & Availability↑

CloneID	OHu13707
Clone ID Related Accession (Same CDS sequence)	NM_012473.3 , NM_012473.4 , XM_006724226.1
Accession Version	NM_012473.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506700800000
Organism	Homo sapiens(human)
Product	thioredoxin, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF480262.1. This sequence is a reference standard in the RefSeqGene project. On Dec 31, 2002 this sequence version replaced NM_012473.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF480262.1, SRR1163655.211827.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152474, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCAGC GACTTCTTCT GAGGAGGTTC CTGGCCTCTG TCATCTCCAG GAAGCCCTCT 
CAGGGTCAGT GGCCACCCCT CACTTCCAGA GCCCTGCAGA CCCCACAATG CAGTCCTGGT 
GGCCTGACTG TAACACCCAA CCCAGCCCGG ACAATATACA CCACGAGGAT CTCCTTGACA 
ACCTTTAATA TCCAGGATGG ACCTGACTTT CAAGACCGAG TGGTCAACAG TGAGACACCA 
GTGGTTGTGG ATTTCCACGC ACAGTGGTGT GGACCCTGCA AGATCCTGGG GCCGAGGTTA 
GAGAAGATGG TGGCCAAGCA GCACGGGAAG GTGGTGATGG CCAAGGTGGA TATTGATGAC 
CACACAGACC TCGCCATTGA GTATGAGGTG TCAGCGGTGC CCACTGTGCT GGCCATGAAG 
AATGGGGACG TGGTGGACAA GTTTGTGGGC ATCAAGGATG AGGATCAGTT GGAGGCCTTC 
CTGAAGAAGC TGATTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036605.2
CDS	78..578
Translation	MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG

Target ORF information:

RefSeq Version	NM_012473.3
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin 2 (TXN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012473.3

ORF Insert Sequence:

ATGGCTCAGC GACTTCTTCT GAGGAGGTTC CTGGCCTCTG TCATCTCCAG GAAGCCCTCT 
CAGGGTCAGT GGCCACCCCT CACTTCCAGA GCCCTGCAGA CCCCACAATG CAGTCCTGGT 
GGCCTGACTG TAACACCCAA CCCAGCCCGG ACAATATACA CCACGAGGAT CTCCTTGACA 
ACCTTTAATA TCCAGGATGG ACCTGACTTT CAAGACCGAG TGGTCAACAG TGAGACACCA 
GTGGTTGTGG ATTTCCACGC ACAGTGGTGT GGACCCTGCA AGATCCTGGG GCCGAGGTTA 
GAGAAGATGG TGGCCAAGCA GCACGGGAAG GTGGTGATGG CCAAGGTGGA TATTGATGAC 
CACACAGACC TCGCCATTGA GTATGAGGTG TCAGCGGTGC CCACTGTGCT GGCCATGAAG 
AATGGGGACG TGGTGGACAA GTTTGTGGGC ATCAAGGATG AGGATCAGTT GGAGGCCTTC 
CTGAAGAAGC TGATTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TXN2 ( NM_012473.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036605.2 Homo sapiens thioredoxin 2 (TXN2), mRNA.

Price & Availability↑

CloneID	OHu13707
Clone ID Related Accession (Same CDS sequence)	NM_012473.3 , NM_012473.4 , XM_006724226.1
Accession Version	NM_012473.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1566316800000
Organism	Homo sapiens(human)
Product	thioredoxin, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL022313.1. This sequence is a reference standard in the RefSeqGene project. On Nov 25, 2018 this sequence version replaced NM_012473.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1074468.1, SRR3476690.1132764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152474, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000216185.7/ ENSP00000216185.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCAGC GACTTCTTCT GAGGAGGTTC CTGGCCTCTG TCATCTCCAG GAAGCCCTCT 
CAGGGTCAGT GGCCACCCCT CACTTCCAGA GCCCTGCAGA CCCCACAATG CAGTCCTGGT 
GGCCTGACTG TAACACCCAA CCCAGCCCGG ACAATATACA CCACGAGGAT CTCCTTGACA 
ACCTTTAATA TCCAGGATGG ACCTGACTTT CAAGACCGAG TGGTCAACAG TGAGACACCA 
GTGGTTGTGG ATTTCCACGC ACAGTGGTGT GGACCCTGCA AGATCCTGGG GCCGAGGTTA 
GAGAAGATGG TGGCCAAGCA GCACGGGAAG GTGGTGATGG CCAAGGTGGA TATTGATGAC 
CACACAGACC TCGCCATTGA GTATGAGGTG TCAGCGGTGC CCACTGTGCT GGCCATGAAG 
AATGGGGACG TGGTGGACAA GTTTGTGGGC ATCAAGGATG AGGATCAGTT GGAGGCCTTC 
CTGAAGAAGC TGATTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036605.2
CDS	78..578
Translation	MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG

Target ORF information:

RefSeq Version	NM_012473.4
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin 2 (TXN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012473.4

ORF Insert Sequence:

ATGGCTCAGC GACTTCTTCT GAGGAGGTTC CTGGCCTCTG TCATCTCCAG GAAGCCCTCT 
CAGGGTCAGT GGCCACCCCT CACTTCCAGA GCCCTGCAGA CCCCACAATG CAGTCCTGGT 
GGCCTGACTG TAACACCCAA CCCAGCCCGG ACAATATACA CCACGAGGAT CTCCTTGACA 
ACCTTTAATA TCCAGGATGG ACCTGACTTT CAAGACCGAG TGGTCAACAG TGAGACACCA 
GTGGTTGTGG ATTTCCACGC ACAGTGGTGT GGACCCTGCA AGATCCTGGG GCCGAGGTTA 
GAGAAGATGG TGGCCAAGCA GCACGGGAAG GTGGTGATGG CCAAGGTGGA TATTGATGAC 
CACACAGACC TCGCCATTGA GTATGAGGTG TCAGCGGTGC CCACTGTGCT GGCCATGAAG 
AATGGGGACG TGGTGGACAA GTTTGTGGGC ATCAAGGATG AGGATCAGTT GGAGGCCTTC 
CTGAAGAAGC TGATTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TXN2 ( XM_006724226.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_006724289.1 Homo sapiens thioredoxin 2 (TXN2), transcript variant X2, mRNA.

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CloneID	OHu13707
Clone ID Related Accession (Same CDS sequence)	NM_012473.3 , NM_012473.4 , XM_006724226.1
Accession Version	XM_006724226.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	thioredoxin, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCAGC GACTTCTTCT GAGGAGGTTC CTGGCCTCTG TCATCTCCAG GAAGCCCTCT 
CAGGGTCAGT GGCCACCCCT CACTTCCAGA GCCCTGCAGA CCCCACAATG CAGTCCTGGT 
GGCCTGACTG TAACACCCAA CCCAGCCCGG ACAATATACA CCACGAGGAT CTCCTTGACA 
ACCTTTAATA TCCAGGATGG ACCTGACTTT CAAGACCGAG TGGTCAACAG TGAGACACCA 
GTGGTTGTGG ATTTCCACGC ACAGTGGTGT GGACCCTGCA AGATCCTGGG GCCGAGGTTA 
GAGAAGATGG TGGCCAAGCA GCACGGGAAG GTGGTGATGG CCAAGGTGGA TATTGATGAC 
CACACAGACC TCGCCATTGA GTATGAGGTG TCAGCGGTGC CCACTGTGCT GGCCATGAAG 
AATGGGGACG TGGTGGACAA GTTTGTGGGC ATCAAGGATG AGGATCAGTT GGAGGCCTTC 
CTGAAGAAGC TGATTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006724289.1
CDS	199..699
Translation	MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG

Target ORF information:

RefSeq Version	XM_006724226.1
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin 2 (TXN2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006724226.1

ORF Insert Sequence:

ATGGCTCAGC GACTTCTTCT GAGGAGGTTC CTGGCCTCTG TCATCTCCAG GAAGCCCTCT 
CAGGGTCAGT GGCCACCCCT CACTTCCAGA GCCCTGCAGA CCCCACAATG CAGTCCTGGT 
GGCCTGACTG TAACACCCAA CCCAGCCCGG ACAATATACA CCACGAGGAT CTCCTTGACA 
ACCTTTAATA TCCAGGATGG ACCTGACTTT CAAGACCGAG TGGTCAACAG TGAGACACCA 
GTGGTTGTGG ATTTCCACGC ACAGTGGTGT GGACCCTGCA AGATCCTGGG GCCGAGGTTA 
GAGAAGATGG TGGCCAAGCA GCACGGGAAG GTGGTGATGG CCAAGGTGGA TATTGATGAC 
CACACAGACC TCGCCATTGA GTATGAGGTG TCAGCGGTGC CCACTGTGCT GGCCATGAAG 
AATGGGGACG TGGTGGACAA GTTTGTGGGC ATCAAGGATG AGGATCAGTT GGAGGCCTTC 
CTGAAGAAGC TGATTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Thioredoxin 2 Offers Protection against Mitochondrial Oxidative Stress in H9c2 Cells and against Myocardial Hypertrophy Induced by Hyperglycemia.
International journal of molecular sciences18(9)(2017 Sep)
Li H,Xu C,Li Q,Gao X,Sugano E,Tomita H,Yang L,Shi S

MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2.
Journal of virology91(12)(2017 06)
Machitani M,Sakurai F,Wakabayashi K,Nakatani K,Tachibana M,Mizuguchi H

Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology312(5)L599-L608(2017 05)
Adesina SE,Wade BE,Bijli KM,Kang BY,Williams CR,Ma J,Go YM,Hart CM,Sutliff RL

Detoxification of Mitochondrial Oxidants and Apoptotic Signaling Are Facilitated by Thioredoxin-2 and Peroxiredoxin-3 during Hyperoxic Injury.
PloS one12(1)e0168777(2017)
Forred BJ,Daugaard DR,Titus BK,Wood RR,Floen MJ,Booze ML,Vitiello PF

Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus.
Journal of diabetes and its complications30(2)192-8(2016 Mar)
Ramus SM,Cilensek I,Petrovic MG,Soucek M,Kruzliak P,Petrovic D

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TXN2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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