LMOD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LMOD1
Entrez Gene ID	25802
Full Name	leiomodin 1
Synonyms	1D,64kD,D1,SM-LMOD,SMLMOD
General protein information	Preferred Names leiomodin 1 Names leiomodin-1 64 kDa autoantigen 1D 64 kDa autoantigen 1D3 64 kDa autoantigen D1 leimodin 1 (smooth muscle) leiomodin 1 (smooth muscle) leiomodin, muscle form smooth muscle leiomodin thyroid and eye muscle autoantigen D1 (64kD) thyroid-associated ophthalmopathy autoantigen
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1
Summary	The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy. [provided by RefSeq, Jul 2008].
Disorder MIM:	602715

mRNA and Protein(s)

mRNA	Protein	Name
NM_012134.2	NP_036266.2	leiomodin-1
NM_012134.3	NP_036266.2	leiomodin-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	LMOD1	NP_036266.2
Pan troglodytes (chimpanzee)	LMOD1	XP_001148071.2
Rattus norvegicus (Norway rat)	Lmod1	NP_001100649.1
Canis lupus familiaris (dog)	LMOD1	XP_005622269.1
Bos taurus (cattle)	LMOD1	NP_001077184.1
Mus musculus (house mouse)	Lmod1	NP_444336.2
Macaca mulatta (Rhesus monkey)	LMOD1	XP_001107926.1
Gallus gallus (chicken)	LMOD1	XP_004934925.1
Xenopus tropicalis (tropical clawed frog)	lmod1	XP_002939676.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus.
Nanda V, Wang T, Pjanic M, Liu B, Nguyen T, Matic LP, Hedin U, Koplev S, Ma L, Franzén O, Ruusalepp A, Schadt EE, Björkegren JLM, Montgomery SB, Snyder MP, Quertermous T, Leeper NJ, Miller CL
PLoS genetics14(11)e1007755(2018 11)

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice.
Halim D, Wilson MP, Oliver D, Brosens E, Verheij JB, Han Y, Nanda V, Lyu Q, Doukas M, Stoop H, Brouwer RW, van IJcken WF, Slivano OJ, Burns AJ, Christie CK, de Mesy Bentley KL, Brooks AS, Tibboel D, Xu S, Jin ZG, Djuwantono T, Yan W, Alves MM, Hofstra RM, Miano JM
Proceedings of the National Academy of Sciences of the United States of America114(13)E2739-E2747(2017 03)

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.
Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-Lleal M, Lengquist M, Miller CL, Ericsson I, Röhl S, Kronqvist M, Aldi S, Magné J, Paloschi V, Vesterlund M, Li Y, Jin H, Diez MG, Roy J, Baldassarre D, Veglia F, Humphries SE, de Faire U, Tremoli E, Odeberg J, Vukojević V, Lehtiö J, Maegdefessel L, Ehrenborg E, Paulsson-Berne G, Hansson GK, Lindeman JH, Eriksson P, Quertermous T, Hamsten A, Hedin U
Arteriosclerosis, thrombosis, and vascular biology36(9)1947-61(2016 09)

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension.
Sahoo S, Meijles DN, Al Ghouleh I, Tandon M, Cifuentes-Pagano E, Sembrat J, Rojas M, Goncharova E, Pagano PJ
PloS one11(5)e0153780(2016)

How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.
Boczkowska M, Rebowski G, Kremneva E, Lappalainen P, Dominguez R
Nature communications68314(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following LMOD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LMOD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06071	NM_012134.3 Latest version!	Homo sapiens leiomodin 1 (LMOD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00
View Old Accession Versions >>
OHu06071	NM_012134.2	Homo sapiens leiomodin 1 (LMOD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LMOD1 ( NM_012134.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036266.2 Homo sapiens leiomodin 1 (LMOD1), mRNA.

Price & Availability↑

CloneID	OHu06071
Clone ID Related Accession (Same CDS sequence)	NM_012134.2 , NM_012134.3
Accession Version	NM_012134.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1803bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	leiomodin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB228115.1, BC080187.1 and AL513217.11. On Aug 16, 2006 this sequence version replaced NM_012134.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC080187.1, X54162.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTAGAG TAGCCAAATA TCGCCGGCAG GTGAGTGAAG ACCCCGACAT CGACAGCCTG 
CTGGAGACCC TGTCTCCCGA GGAGATGGAG GAGCTGGAGA AGGAGCTGGA CGTGGTGGAC 
CCAGACGGGA GTGTTCCCGT GGGGCTGCGG CAGAGAAACC AGACGGAGAA ACAGTCCACG 
GGTGTGTACA ACCGGGAGGC CATGCTCAAC TTCTGTGAAA AGGAGACCAA GAAACTTATG 
CAGAGGGAGA TGTCCATGGA TGAAAGCAAG CAAGTGGAGA CCAAGACAGA TGCCAAGAAT 
GGAGAGGAAA GGGGCAGAGA TGCCAGCAAA AAAGCCCTGG GCCCCAGACG GGACTCAGAT 
CTGGGGAAGG AGCCAAAGAG GGGTGGTTTA AAGAAAAGCT TCTCTAGAGA CAGAGATGAA 
GCTGGTGGCA AGAGTGGCGA GAAGCCCAAG GAGGAGAAGA TCATCCGGGG CATTGACAAG 
GGCCGGGTCA GGGCTGCAGT GGATAAGAAG GAGGCAGGGA AGGATGGGAG AGGAGAGGAG 
AGGGCAGTGG CCACCAAGAA GGAAGAGGAG AAGAAAGGGA GTGACAGGAA CACAGGCTTG 
AGCAGGGACA AGGATAAAAA GAGAGAGGAG ATGAAGGAGG TGGCCAAGAA AGAGGATGAT 
GAGAAGGTAA AAGGGGAGCG TAGGAACACA GACACCAGAA AAGAGGGTGA GAAGATGAAA 
AGAGCAGGTG GGAACACAGA CATGAAAAAG GAGGATGAGA AGGTAAAAAG AGGAACTGGG 
AACACAGACA CCAAAAAGGA CGATGAAAAA GTCAAGAAGA ATGAACCCTT ACATGAAAAG 
GAAGCCAAGG ATGACAGCAA GACCAAAACA CCCGAGAAAC AGACGCCCAG TGGCCCCACC 
AAGCCCTCTG AAGGACCGGC CAAGGTGGAG GAGGAGGCAG CTCCCAGCAT ATTTGATGAG 
CCTCTGGAGA GAGTGAAGAA CAATGACCCC GAGATGACTG AGGTGAACGT CAACAACTCA 
GACTGCATCA CAAATGAGAT CTTGGTCCGG TTTACTGAGG CTCTGGAGTT CAACACTGTG 
GTTAAGCTGT TCGCCTTGGC CAACACGCGA GCCGATGACC ACGTGGCCTT TGCCATTGCC 
ATCATGCTCA AGGCCAACAA GACCATCACC AGCCTCAACC TGGACTCCAA CCACATCACA 
GGCAAAGGCA TCCTGGCCAT CTTCCGGGCC CTCCTCCAGA ACAACACGCT GACCGAGCTC 
CGCTTCCACA ACCAGCGACA CATCTGTGGA GGCAAGACGG AGATGGAGAT CGCCAAGCTG 
CTGAAGGAGA ATACTACCCT GCTCAAGCTG GGCTACCATT TTGAGCTGGC CGGGCCCCGA 
ATGACTGTCA CCAATCTGCT CAGCCGCAAC ATGGACAAGC AGAGACAAAA GCGGCTGCAG 
GAGCAAAGGC AGGCACAGGA AGCCAAGGGA GAGAAGAAGG ATCTGCTGGA GGTACCCAAG 
GCCGGGGCCG TGGCTAAGGG CTCCCCAAAA CCTTCACCTC AACCATCTCC AAAGCCCTCT 
CCAAAGAACT CACCCAAAAA AGGGGGTGCT CCAGCTGCCC CACCACCCCC TCCCCCTCCC 
TTGGCTCCAC CCCTTATCAT GGAGAACCTG AAGAATTCAC TCTCACCAGC TACCCAGAGG 
AAGATGGGAG ACAAAGTCCT CCCTGCCCAG GAGAAGAACT CCCGTGACCA GCTATTGGCT 
GCCATCCGCT CCAGCAACCT CAAGCAGCTC AAGAAGGTGG AAGTGCCCAA ACTGCTTCAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036266.2
CDS	249..2051
Translation	MSRVAKYRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTELRFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRLQEQRQAQEAKGEKKDLLEVPKAGAVAKGSPKPSPQPSPKPSPKNSPKKGGAPAAPPPPPPPLAPPLIMENLKNSLSPATQRKMGDKVLPAQEKNSRDQLLAAIRSSNLKQLKKVEVPKLLQ

Target ORF information:

RefSeq Version	NM_012134.2
Organism	Homo sapiens(human)
Definition	Homo sapiens leiomodin 1 (LMOD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012134.2

ORF Insert Sequence:

ATGTCTAGAG TAGCCAAATA TCGCCGGCAG GTGAGTGAAG ACCCCGACAT CGACAGCCTG 
CTGGAGACCC TGTCTCCCGA GGAGATGGAG GAGCTGGAGA AGGAGCTGGA CGTGGTGGAC 
CCAGACGGGA GTGTTCCCGT GGGGCTGCGG CAGAGAAACC AGACGGAGAA ACAGTCCACG 
GGTGTGTACA ACCGGGAGGC CATGCTCAAC TTCTGTGAAA AGGAGACCAA GAAACTTATG 
CAGAGGGAGA TGTCCATGGA TGAAAGCAAG CAAGTGGAGA CCAAGACAGA TGCCAAGAAT 
GGAGAGGAAA GGGGCAGAGA TGCCAGCAAA AAAGCCCTGG GCCCCAGACG GGACTCAGAT 
CTGGGGAAGG AGCCAAAGAG GGGTGGTTTA AAGAAAAGCT TCTCTAGAGA CAGAGATGAA 
GCTGGTGGCA AGAGTGGCGA GAAGCCCAAG GAGGAGAAGA TCATCCGGGG CATTGACAAG 
GGCCGGGTCA GGGCTGCAGT GGATAAGAAG GAGGCAGGGA AGGATGGGAG AGGAGAGGAG 
AGGGCAGTGG CCACCAAGAA GGAAGAGGAG AAGAAAGGGA GTGACAGGAA CACAGGCTTG 
AGCAGGGACA AGGATAAAAA GAGAGAGGAG ATGAAGGAGG TGGCCAAGAA AGAGGATGAT 
GAGAAGGTAA AAGGGGAGCG TAGGAACACA GACACCAGAA AAGAGGGTGA GAAGATGAAA 
AGAGCAGGTG GGAACACAGA CATGAAAAAG GAGGATGAGA AGGTAAAAAG AGGAACTGGG 
AACACAGACA CCAAAAAGGA CGATGAAAAA GTCAAGAAGA ATGAACCCTT ACATGAAAAG 
GAAGCCAAGG ATGACAGCAA GACCAAAACA CCCGAGAAAC AGACGCCCAG TGGCCCCACC 
AAGCCCTCTG AAGGACCGGC CAAGGTGGAG GAGGAGGCAG CTCCCAGCAT ATTTGATGAG 
CCTCTGGAGA GAGTGAAGAA CAATGACCCC GAGATGACTG AGGTGAACGT CAACAACTCA 
GACTGCATCA CAAATGAGAT CTTGGTCCGG TTTACTGAGG CTCTGGAGTT CAACACTGTG 
GTTAAGCTGT TCGCCTTGGC CAACACGCGA GCCGATGACC ACGTGGCCTT TGCCATTGCC 
ATCATGCTCA AGGCCAACAA GACCATCACC AGCCTCAACC TGGACTCCAA CCACATCACA 
GGCAAAGGCA TCCTGGCCAT CTTCCGGGCC CTCCTCCAGA ACAACACGCT GACCGAGCTC 
CGCTTCCACA ACCAGCGACA CATCTGTGGA GGCAAGACGG AGATGGAGAT CGCCAAGCTG 
CTGAAGGAGA ATACTACCCT GCTCAAGCTG GGCTACCATT TTGAGCTGGC CGGGCCCCGA 
ATGACTGTCA CCAATCTGCT CAGCCGCAAC ATGGACAAGC AGAGACAAAA GCGGCTGCAG 
GAGCAAAGGC AGGCACAGGA AGCCAAGGGA GAGAAGAAGG ATCTGCTGGA GGTACCCAAG 
GCCGGGGCCG TGGCTAAGGG CTCCCCAAAA CCTTCACCTC AACCATCTCC AAAGCCCTCT 
CCAAAGAACT CACCCAAAAA AGGGGGTGCT CCAGCTGCCC CACCACCCCC TCCCCCTCCC 
TTGGCTCCAC CCCTTATCAT GGAGAACCTG AAGAATTCAC TCTCACCAGC TACCCAGAGG 
AAGATGGGAG ACAAAGTCCT CCCTGCCCAG GAGAAGAACT CCCGTGACCA GCTATTGGCT 
GCCATCCGCT CCAGCAACCT CAAGCAGCTC AAGAAGGTGG AAGTGCCCAA ACTGCTTCAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMOD1 ( NM_012134.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036266.2 Homo sapiens leiomodin 1 (LMOD1), mRNA.

Price & Availability↑

CloneID	OHu06071
Clone ID Related Accession (Same CDS sequence)	NM_012134.2 , NM_012134.3
Accession Version	NM_012134.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1803bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569427200000
Organism	Homo sapiens(human)
Product	leiomodin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC099676.2 and AL513217.11. On Nov 23, 2018 this sequence version replaced NM_012134.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC080187.1, X54162.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367288.5/ ENSP00000356257.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTAGAG TAGCCAAATA TCGCCGGCAG GTGAGTGAAG ACCCCGACAT CGACAGCCTG 
CTGGAGACCC TGTCTCCCGA GGAGATGGAG GAGCTGGAGA AGGAGCTGGA CGTGGTGGAC 
CCAGACGGGA GTGTTCCCGT GGGGCTGCGG CAGAGAAACC AGACGGAGAA ACAGTCCACG 
GGTGTGTACA ACCGGGAGGC CATGCTCAAC TTCTGTGAAA AGGAGACCAA GAAACTTATG 
CAGAGGGAGA TGTCCATGGA TGAAAGCAAG CAAGTGGAGA CCAAGACAGA TGCCAAGAAT 
GGAGAGGAAA GGGGCAGAGA TGCCAGCAAA AAAGCCCTGG GCCCCAGACG GGACTCAGAT 
CTGGGGAAGG AGCCAAAGAG GGGTGGTTTA AAGAAAAGCT TCTCTAGAGA CAGAGATGAA 
GCTGGTGGCA AGAGTGGCGA GAAGCCCAAG GAGGAGAAGA TCATCCGGGG CATTGACAAG 
GGCCGGGTCA GGGCTGCAGT GGATAAGAAG GAGGCAGGGA AGGATGGGAG AGGAGAGGAG 
AGGGCAGTGG CCACCAAGAA GGAAGAGGAG AAGAAAGGGA GTGACAGGAA CACAGGCTTG 
AGCAGGGACA AGGATAAAAA GAGAGAGGAG ATGAAGGAGG TGGCCAAGAA AGAGGATGAT 
GAGAAGGTAA AAGGGGAGCG TAGGAACACA GACACCAGAA AAGAGGGTGA GAAGATGAAA 
AGAGCAGGTG GGAACACAGA CATGAAAAAG GAGGATGAGA AGGTAAAAAG AGGAACTGGG 
AACACAGACA CCAAAAAGGA CGATGAAAAA GTCAAGAAGA ATGAACCCTT ACATGAAAAG 
GAAGCCAAGG ATGACAGCAA GACCAAAACA CCCGAGAAAC AGACGCCCAG TGGCCCCACC 
AAGCCCTCTG AAGGACCGGC CAAGGTGGAG GAGGAGGCAG CTCCCAGCAT ATTTGATGAG 
CCTCTGGAGA GAGTGAAGAA CAATGACCCC GAGATGACTG AGGTGAACGT CAACAACTCA 
GACTGCATCA CAAATGAGAT CTTGGTCCGG TTTACTGAGG CTCTGGAGTT CAACACTGTG 
GTTAAGCTGT TCGCCTTGGC CAACACGCGA GCCGATGACC ACGTGGCCTT TGCCATTGCC 
ATCATGCTCA AGGCCAACAA GACCATCACC AGCCTCAACC TGGACTCCAA CCACATCACA 
GGCAAAGGCA TCCTGGCCAT CTTCCGGGCC CTCCTCCAGA ACAACACGCT GACCGAGCTC 
CGCTTCCACA ACCAGCGACA CATCTGTGGA GGCAAGACGG AGATGGAGAT CGCCAAGCTG 
CTGAAGGAGA ATACTACCCT GCTCAAGCTG GGCTACCATT TTGAGCTGGC CGGGCCCCGA 
ATGACTGTCA CCAATCTGCT CAGCCGCAAC ATGGACAAGC AGAGACAAAA GCGGCTGCAG 
GAGCAAAGGC AGGCACAGGA AGCCAAGGGA GAGAAGAAGG ATCTGCTGGA GGTACCCAAG 
GCCGGGGCCG TGGCTAAGGG CTCCCCAAAA CCTTCACCTC AACCATCTCC AAAGCCCTCT 
CCAAAGAACT CACCCAAAAA AGGGGGTGCT CCAGCTGCCC CACCACCCCC TCCCCCTCCC 
TTGGCTCCAC CCCTTATCAT GGAGAACCTG AAGAATTCAC TCTCACCAGC TACCCAGAGG 
AAGATGGGAG ACAAAGTCCT CCCTGCCCAG GAGAAGAACT CCCGTGACCA GCTATTGGCT 
GCCATCCGCT CCAGCAACCT CAAGCAGCTC AAGAAGGTGG AAGTGCCCAA ACTGCTTCAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036266.2
CDS	209..2011
Translation	MSRVAKYRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTELRFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRLQEQRQAQEAKGEKKDLLEVPKAGAVAKGSPKPSPQPSPKPSPKNSPKKGGAPAAPPPPPPPLAPPLIMENLKNSLSPATQRKMGDKVLPAQEKNSRDQLLAAIRSSNLKQLKKVEVPKLLQ

Target ORF information:

RefSeq Version	NM_012134.3
Organism	Homo sapiens(human)
Definition	Homo sapiens leiomodin 1 (LMOD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012134.3

ORF Insert Sequence:

ATGTCTAGAG TAGCCAAATA TCGCCGGCAG GTGAGTGAAG ACCCCGACAT CGACAGCCTG 
CTGGAGACCC TGTCTCCCGA GGAGATGGAG GAGCTGGAGA AGGAGCTGGA CGTGGTGGAC 
CCAGACGGGA GTGTTCCCGT GGGGCTGCGG CAGAGAAACC AGACGGAGAA ACAGTCCACG 
GGTGTGTACA ACCGGGAGGC CATGCTCAAC TTCTGTGAAA AGGAGACCAA GAAACTTATG 
CAGAGGGAGA TGTCCATGGA TGAAAGCAAG CAAGTGGAGA CCAAGACAGA TGCCAAGAAT 
GGAGAGGAAA GGGGCAGAGA TGCCAGCAAA AAAGCCCTGG GCCCCAGACG GGACTCAGAT 
CTGGGGAAGG AGCCAAAGAG GGGTGGTTTA AAGAAAAGCT TCTCTAGAGA CAGAGATGAA 
GCTGGTGGCA AGAGTGGCGA GAAGCCCAAG GAGGAGAAGA TCATCCGGGG CATTGACAAG 
GGCCGGGTCA GGGCTGCAGT GGATAAGAAG GAGGCAGGGA AGGATGGGAG AGGAGAGGAG 
AGGGCAGTGG CCACCAAGAA GGAAGAGGAG AAGAAAGGGA GTGACAGGAA CACAGGCTTG 
AGCAGGGACA AGGATAAAAA GAGAGAGGAG ATGAAGGAGG TGGCCAAGAA AGAGGATGAT 
GAGAAGGTAA AAGGGGAGCG TAGGAACACA GACACCAGAA AAGAGGGTGA GAAGATGAAA 
AGAGCAGGTG GGAACACAGA CATGAAAAAG GAGGATGAGA AGGTAAAAAG AGGAACTGGG 
AACACAGACA CCAAAAAGGA CGATGAAAAA GTCAAGAAGA ATGAACCCTT ACATGAAAAG 
GAAGCCAAGG ATGACAGCAA GACCAAAACA CCCGAGAAAC AGACGCCCAG TGGCCCCACC 
AAGCCCTCTG AAGGACCGGC CAAGGTGGAG GAGGAGGCAG CTCCCAGCAT ATTTGATGAG 
CCTCTGGAGA GAGTGAAGAA CAATGACCCC GAGATGACTG AGGTGAACGT CAACAACTCA 
GACTGCATCA CAAATGAGAT CTTGGTCCGG TTTACTGAGG CTCTGGAGTT CAACACTGTG 
GTTAAGCTGT TCGCCTTGGC CAACACGCGA GCCGATGACC ACGTGGCCTT TGCCATTGCC 
ATCATGCTCA AGGCCAACAA GACCATCACC AGCCTCAACC TGGACTCCAA CCACATCACA 
GGCAAAGGCA TCCTGGCCAT CTTCCGGGCC CTCCTCCAGA ACAACACGCT GACCGAGCTC 
CGCTTCCACA ACCAGCGACA CATCTGTGGA GGCAAGACGG AGATGGAGAT CGCCAAGCTG 
CTGAAGGAGA ATACTACCCT GCTCAAGCTG GGCTACCATT TTGAGCTGGC CGGGCCCCGA 
ATGACTGTCA CCAATCTGCT CAGCCGCAAC ATGGACAAGC AGAGACAAAA GCGGCTGCAG 
GAGCAAAGGC AGGCACAGGA AGCCAAGGGA GAGAAGAAGG ATCTGCTGGA GGTACCCAAG 
GCCGGGGCCG TGGCTAAGGG CTCCCCAAAA CCTTCACCTC AACCATCTCC AAAGCCCTCT 
CCAAAGAACT CACCCAAAAA AGGGGGTGCT CCAGCTGCCC CACCACCCCC TCCCCCTCCC 
TTGGCTCCAC CCCTTATCAT GGAGAACCTG AAGAATTCAC TCTCACCAGC TACCCAGAGG 
AAGATGGGAG ACAAAGTCCT CCCTGCCCAG GAGAAGAACT CCCGTGACCA GCTATTGGCT 
GCCATCCGCT CCAGCAACCT CAAGCAGCTC AAGAAGGTGG AAGTGCCCAA ACTGCTTCAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus.
PLoS genetics14(11)e1007755(2018 11)
Nanda V,Wang T,Pjanic M,Liu B,Nguyen T,Matic LP,Hedin U,Koplev S,Ma L,Franzén O,Ruusalepp A,Schadt EE,Björkegren JLM,Montgomery SB,Snyder MP,Quertermous T,Leeper NJ,Miller CL

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice.
Proceedings of the National Academy of Sciences of the United States of America114(13)E2739-E2747(2017 03)
Halim D,Wilson MP,Oliver D,Brosens E,Verheij JB,Han Y,Nanda V,Lyu Q,Doukas M,Stoop H,Brouwer RW,van IJcken WF,Slivano OJ,Burns AJ,Christie CK,de Mesy Bentley KL,Brooks AS,Tibboel D,Xu S,Jin ZG,Djuwantono T,Yan W,Alves MM,Hofstra RM,Miano JM

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.
Arteriosclerosis, thrombosis, and vascular biology36(9)1947-61(2016 09)
Perisic Matic L,Rykaczewska U,Razuvaev A,Sabater-Lleal M,Lengquist M,Miller CL,Ericsson I,Röhl S,Kronqvist M,Aldi S,Magné J,Paloschi V,Vesterlund M,Li Y,Jin H,Diez MG,Roy J,Baldassarre D,Veglia F,Humphries SE,de Faire U,Tremoli E,Odeberg J,Vukojević V,Lehtiö J,Maegdefessel L,Ehrenborg E,Paulsson-Berne G,Hansson GK,Lindeman JH,Eriksson P,Quertermous T,Hamsten A,Hedin U

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension.
PloS one11(5)e0153780(2016)
Sahoo S,Meijles DN,Al Ghouleh I,Tandon M,Cifuentes-Pagano E,Sembrat J,Rojas M,Goncharova E,Pagano PJ

How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.
Nature communications68314(2015 Sep)
Boczkowska M,Rebowski G,Kremneva E,Lappalainen P,Dominguez R

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