MTREX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MTREX
Entrez Gene ID	23517
Full Name	Mtr4 exosome RNA helicase
Synonyms	Dob1,KIAA0052,Mtr4,SKIV2L2,fSAP118
General protein information	Preferred Names Mtr4 exosome RNA helicase Names superkiller viralicidic activity 2-like 2 ATP-dependent RNA helicase DOB1 ATP-dependent RNA helicase SKIV2L2 ATP-dependent helicase SKIV2L2 Ski2 like RNA helicase 2 TRAMP-like complex helicase functional spliceosome-associated protein 118
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q11.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_015360.5	NP_056175.3	exosome RNA helicase MTR4
NM_015360.4	NP_056175.3	superkiller viralicidic activity 2-like 2

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009600	XP_318627.4
Canis lupus familiaris (dog)	SKIV2L2	XP_849676.1
Kluyveromyces lactis	KLLA0F01364g	XP_455141.1
Homo sapiens (human)	SKIV2L2	NP_056175.3
Rattus norvegicus (Norway rat)	Skiv2l2	NP_001029265.1
Caenorhabditis elegans (roundworm)	mtr-4	NP_501757.1
Neurospora crassa	NCU03363	XP_956298.1
Schizosaccharomyces pombe (fission yeast)	mtr4	NP_593302.1
Pan troglodytes (chimpanzee)	SKIV2L2	XP_001145794.1
Arabidopsis thaliana (thale cress)	AT1G59760	NP_176185.1
Xenopus tropicalis (tropical clawed frog)	skiv2l2	XP_002941157.1
Saccharomyces cerevisiae (baker's yeast)	MTR4	NP_012485.1
Macaca mulatta (Rhesus monkey)	LOC706419	XP_002808474.1
Mus musculus (house mouse)	Skiv2l2	NP_082427.1
Gallus gallus (chicken)	SKIV2L2	NP_001012962.1
Danio rerio (zebrafish)	skiv2l2	NP_999933.1
Drosophila melanogaster (fruit fly)	l(2)35Df	NP_524929.1
Magnaporthe oryzae (rice blast fungus)	MGG_03931	XP_003719933.1
Eremothecium gossypii	AGOS_AEL181C	NP_984680.2

Gene Ontology
Bibliography

Related articles in PubMed

The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
Lingaraju M, Johnsen D, Schlundt A, Langer LM, Basquin J, Sattler M, Heick Jensen T, Falk S, Conti E
Nature communications10(1)3393(2019 07)

NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Wang J, Chen J, Wu G, Zhang H, Du X, Chen S, Zhang L, Wang K, Fan J, Gao S, Wu X, Zhang S, Kuai B, Zhao P, Chi B, Wang L, Li G, Wong CCL, Zhou Y, Li J, Yun C, Cheng H
Genes & development33(9-10)536-549(2019 05)

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.
Bugai A, Quaresma AJC, Friedel CC, Lenasi T, Düster R, Sibley CR, Fujinaga K, Kukanja P, Hennig T, Blasius M, Geyer M, Ule J, Dölken L, Barborič M
Molecular cell74(2)254-267.e10(2019 04)

Distinct and evolutionary conserved structural features of the human nuclear exosome complex.
Gerlach P, Schuller JM, Bonneau F, Basquin J, Reichelt P, Falk S, Conti E
eLife7(2018 07)

Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.
Weick EM, Puno MR, Januszyk K, Zinder JC, DiMattia MA, Lima CD
Cell173(7)1663-1677.e21(2018 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MTREX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MTREX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08849	NM_015360.5 Latest version!	Homo sapiens Mtr4 exosome RNA helicase (MTREX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu08849	NM_015360.4	Homo sapiens Mtr4 exosome RNA helicase (MTREX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MTREX ( NM_015360.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_056175.3 Homo sapiens Mtr4 exosome RNA helicase (MTREX), mRNA.

Price & Availability↑

CloneID	OHu08849
Clone ID Related Accession (Same CDS sequence)	NM_015360.5 , NM_015360.4
Accession Version	NM_015360.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3129bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1578067200000
Organism	Homo sapiens(human)
Product	exosome RNA helicase MTR4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX640789.1 and BC065258.1. On Nov 23, 2018 this sequence version replaced NM_015360.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.5879.1, SRR1660803.33243.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000230640.10/ ENSP00000230640.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGACG CATTCGGAGA TGAGCTGTTC AGCGTGTTCG AGGGCGACTC GACCACTGCG 
GCGGGAACCA AAAAAGACAA GGAAAAGGAC AAGGGGAAAT GGAAGGGGCC TCCAGGGTCT 
GCAGACAAGG CAGGGAAACG TTTTGATGGT AAATTACAAT CAGAATCAAC TAATAATGGA 
AAAAATAAGA GAGATGTAGA TTTCGAAGGT ACAGATGAAC CCATTTTTGG AAAGAAGCCC 
AGGATAGAAG AGTCAATAAC TGAAGACTTA AGTTTGGCAG ACCTGATGCC CAGAGTCAAG 
GTACAATCAG TTGAAACTGT TGAAGGGTGT ACACATGAGG TTGCACTTCC TGCAGAAGAG 
GATTATTTAC CACTTAAACC ACGAGTTGGA AAAGCTGCTA AGGAATACCC GTTCATTCTT 
GATGCTTTTC AAAGAGAGGC CATTCAGTGT GTTGACAATA ATCAGTCTGT TCTAGTATCT 
GCACATACCT CAGCGGGAAA AACAGTATGC GCCGAGTATG CCATTGCATT GGCCTTAAGG 
GAAAAGCAGC GTGTAATATT TACCAGCCCA ATTAAGGCTC TGAGTAACCA AAAATACCGT 
GAAATGTATG AAGAATTTCA AGATGTTGGT TTGATGACTG GTGATGTTAC TATTAATCCT 
ACGGCATCTT GTCTTGTTAT GACCACAGAG ATTTTGAGAA GTATGCTTTA CAGAGGTTCC 
GAAGTTATGA GAGAAGTTGC TTGGGTTATA TTTGATGAAA TTCATTATAT GAGAGATTCA 
GAACGTGGTG TAGTATGGGA AGAAACTATT ATTTTGCTTC CTGATAACGT CCACTATGTC 
TTTCTTTCGG CTACTATTCC AAATGCCCGA CAGTTTGCTG AATGGATTTG CCATTTACAT 
AAACAGCCTT GTCATGTTAT TTACACAGAT TATCGGCCCA CTCCATTGCA ACACTACATT 
TTTCCAGCAG GGGGAGATGG CCTGCATCTT GTGGTTGATG AAAATGGTGA CTTCAGAGAA 
GATAATTTTA ATACTGCAAT GCAAGTGCTT CGAGATGCAG GTGATTTGGC CAAAGGAGAC 
CAGAAAGGGC GGAAAGGAGG AACAAAAGGA CCATCAAATG TTTTCAAAAT TGTGAAGATG 
ATTATGGAAA GAAATTTCCA ACCTGTGATT ATTTTCAGTT TTAGTAAGAA AGATTGTGAA 
GCCTATGCAC TTCAAATGAC CAAATTAGAT TTCAACACAG ATGAAGAAAA GAAGATGGTT 
GAAGAAGTAT TCAGTAATGC AATTGATTGC TTATCCGATG AAGATAAAAA ACTCCCTCAG 
GTAGAACATG TACTTCCTCT TTTGAAGAGG GGAATTGGTA TTCACCATGG TGGTTTACTT 
CCTATTTTGA AAGAAACTAT AGAAATTCTC TTTTCTGAAG GATTGATAAA GGCCTTATTT 
GCCACGGAGA CCTTTGCTAT GGGAATTAAC ATGCCAGCTA GAACTGTTTT ATTTACAAAT 
GCCCGCAAAT TTGATGGGAA GGATTTCCGA TGGATTTCTT CTGGTGAATA CATTCAGATG 
TCTGGTCGTG CTGGAAGGAG AGGAATGGAT GATAGAGGAA TTGTAATTCT TATGGTAGAT 
GAAAAGATGA GCCCAACAAT TGGAAAACAA TTACTTAAGG GCTCCGCTGA TCCTCTAAAT 
AGTGCTTTCC ATTTGACCTA CAACATGGTT TTGAACTTAC TACGTGTAGA AGAAATTAAT 
CCTGAGTACA TGTTGGAAAA ATCCTTCTAC CAGTTTCAGC ATTATAGAGC AATTCCAGGA 
GTAGTAGAGA AGGTAAAGAA TTCAGAAGAA CAGTATAATA AAATAGTAAT TCCCAATGAA 
GAAAGTGTGG TTATCTATTA TAAGATTAGA CAGCAGCTTG CCAAATTGGG TAAAGAAATT 
GAAGAATATA TTCACAAACC AAAATACTGC TTACCTTTTC TACAACCAGG TCGTTTGGTA 
AAGGTAAAGA ATGAAGGAGA TGACTTTGGC TGGGGAGTAG TGGTGAATTT CTCAAAAAAG 
TCAAATGTTA AGCCTAACTC TGGTGAACTG GATCCTTTGT ATGTAGTAGA AGTACTTCTG 
CGCTGTAGCA AAGAGAGCTT GAAAAATTCA GCTACAGAAG CTGCAAAACC AGCTAAACCT 
GATGAGAAAG GAGAGATGCA GGTTGTCCCA GTTTTGGTGC ATCTCCTGTC TGCTATCAGC 
AGTGTTAGGC TTTACATTCC TAAAGACCTT CGGCCGGTGG ACAATAGACA GAGTGTTTTA 
AAATCAATAC AGGAAGTTCA GAAACGTTTT CCTGACGGCA TCCCCTTATT AGACCCTATT 
GATGATATGG GCATTCAAGA TCAAGGGCTG AAAAAAGTCA TTCAGAAAGT AGAAGCTTTT 
GAGCATCGAA TGTATTCTCA TCCACTTCAC AATGATCCAA ATTTGGAAAC TGTGTATACG 
CTTTGTGAAA AAAAAGCACA GATTGCAATA GATATTAAAT CTGCAAAGCG AGAACTGAAG 
AAAGCAAGAA CAGTCCTACA AATGGATGAA CTCAAATGTC GCAAACGTGT TTTAAGAAGG 
TTGGGATTTG CTACTTCTTC TGATGTAATA GAGATGAAAG GACGAGTGGC TTGTGAGATA 
AGCAGTGCTG ATGAGCTCCT TCTAACTGAG ATGATGTTTA ATGGCCTTTT CAATGACCTT 
TCTGCAGAAC AGGCAACAGC ATTATTAAGC TGCTTTGTGT TTCAAGAGAA TTCTAGTGAG 
ATGCCCAAAT TAACAGAACA ATTAGCAGGA CCACTTCGTC AAATGCAGGA ATGTGCTAAA 
AGAATTGCAA AAGTTTCAGC AGAAGCCAAA TTGGAAATTG ATGAGGAAAC TTATCTAAGC 
TCATTTAAAC CTCACTTAAT GGATGTAGTA TATACCTGGG CAACTGGAGC TACATTTGCC 
CATATCTGCA AAATGACAGA TGTCTTTGAA GGCAGCATAA TTCGTTGTAT GAGGCGCCTG 
GAAGAATTGC TTCGACAAAT GTGTCAAGCA GCAAAAGCCA TTGGAAACAC TGAGCTGGAA 
AATAAATTTG CAGAAGGAAT CACCAAAATC AAGAGAGATA TTGTGTTTGC TGCCAGCCTC 
TACTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056175.3
CDS	26..3154
Translation	MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLYL

Target ORF information:

RefSeq Version	NM_015360.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Mtr4 exosome RNA helicase (MTREX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015360.5

ORF Insert Sequence:

ATGGCGGACG CATTCGGAGA TGAGCTGTTC AGCGTGTTCG AGGGCGACTC GACCACTGCG 
GCGGGAACCA AAAAAGACAA GGAAAAGGAC AAGGGGAAAT GGAAGGGGCC TCCAGGGTCT 
GCAGACAAGG CAGGGAAACG TTTTGATGGT AAATTACAAT CAGAATCAAC TAATAATGGA 
AAAAATAAGA GAGATGTAGA TTTCGAAGGT ACAGATGAAC CCATTTTTGG AAAGAAGCCC 
AGGATAGAAG AGTCAATAAC TGAAGACTTA AGTTTGGCAG ACCTGATGCC CAGAGTCAAG 
GTACAATCAG TTGAAACTGT TGAAGGGTGT ACACATGAGG TTGCACTTCC TGCAGAAGAG 
GATTATTTAC CACTTAAACC ACGAGTTGGA AAAGCTGCTA AGGAATACCC GTTCATTCTT 
GATGCTTTTC AAAGAGAGGC CATTCAGTGT GTTGACAATA ATCAGTCTGT TCTAGTATCT 
GCACATACCT CAGCGGGAAA AACAGTATGC GCCGAGTATG CCATTGCATT GGCCTTAAGG 
GAAAAGCAGC GTGTAATATT TACCAGCCCA ATTAAGGCTC TGAGTAACCA AAAATACCGT 
GAAATGTATG AAGAATTTCA AGATGTTGGT TTGATGACTG GTGATGTTAC TATTAATCCT 
ACGGCATCTT GTCTTGTTAT GACCACAGAG ATTTTGAGAA GTATGCTTTA CAGAGGTTCC 
GAAGTTATGA GAGAAGTTGC TTGGGTTATA TTTGATGAAA TTCATTATAT GAGAGATTCA 
GAACGTGGTG TAGTATGGGA AGAAACTATT ATTTTGCTTC CTGATAACGT CCACTATGTC 
TTTCTTTCGG CTACTATTCC AAATGCCCGA CAGTTTGCTG AATGGATTTG CCATTTACAT 
AAACAGCCTT GTCATGTTAT TTACACAGAT TATCGGCCCA CTCCATTGCA ACACTACATT 
TTTCCAGCAG GGGGAGATGG CCTGCATCTT GTGGTTGATG AAAATGGTGA CTTCAGAGAA 
GATAATTTTA ATACTGCAAT GCAAGTGCTT CGAGATGCAG GTGATTTGGC CAAAGGAGAC 
CAGAAAGGGC GGAAAGGAGG AACAAAAGGA CCATCAAATG TTTTCAAAAT TGTGAAGATG 
ATTATGGAAA GAAATTTCCA ACCTGTGATT ATTTTCAGTT TTAGTAAGAA AGATTGTGAA 
GCCTATGCAC TTCAAATGAC CAAATTAGAT TTCAACACAG ATGAAGAAAA GAAGATGGTT 
GAAGAAGTAT TCAGTAATGC AATTGATTGC TTATCCGATG AAGATAAAAA ACTCCCTCAG 
GTAGAACATG TACTTCCTCT TTTGAAGAGG GGAATTGGTA TTCACCATGG TGGTTTACTT 
CCTATTTTGA AAGAAACTAT AGAAATTCTC TTTTCTGAAG GATTGATAAA GGCCTTATTT 
GCCACGGAGA CCTTTGCTAT GGGAATTAAC ATGCCAGCTA GAACTGTTTT ATTTACAAAT 
GCCCGCAAAT TTGATGGGAA GGATTTCCGA TGGATTTCTT CTGGTGAATA CATTCAGATG 
TCTGGTCGTG CTGGAAGGAG AGGAATGGAT GATAGAGGAA TTGTAATTCT TATGGTAGAT 
GAAAAGATGA GCCCAACAAT TGGAAAACAA TTACTTAAGG GCTCCGCTGA TCCTCTAAAT 
AGTGCTTTCC ATTTGACCTA CAACATGGTT TTGAACTTAC TACGTGTAGA AGAAATTAAT 
CCTGAGTACA TGTTGGAAAA ATCCTTCTAC CAGTTTCAGC ATTATAGAGC AATTCCAGGA 
GTAGTAGAGA AGGTAAAGAA TTCAGAAGAA CAGTATAATA AAATAGTAAT TCCCAATGAA 
GAAAGTGTGG TTATCTATTA TAAGATTAGA CAGCAGCTTG CCAAATTGGG TAAAGAAATT 
GAAGAATATA TTCACAAACC AAAATACTGC TTACCTTTTC TACAACCAGG TCGTTTGGTA 
AAGGTAAAGA ATGAAGGAGA TGACTTTGGC TGGGGAGTAG TGGTGAATTT CTCAAAAAAG 
TCAAATGTTA AGCCTAACTC TGGTGAACTG GATCCTTTGT ATGTAGTAGA AGTACTTCTG 
CGCTGTAGCA AAGAGAGCTT GAAAAATTCA GCTACAGAAG CTGCAAAACC AGCTAAACCT 
GATGAGAAAG GAGAGATGCA GGTTGTCCCA GTTTTGGTGC ATCTCCTGTC TGCTATCAGC 
AGTGTTAGGC TTTACATTCC TAAAGACCTT CGGCCGGTGG ACAATAGACA GAGTGTTTTA 
AAATCAATAC AGGAAGTTCA GAAACGTTTT CCTGACGGCA TCCCCTTATT AGACCCTATT 
GATGATATGG GCATTCAAGA TCAAGGGCTG AAAAAAGTCA TTCAGAAAGT AGAAGCTTTT 
GAGCATCGAA TGTATTCTCA TCCACTTCAC AATGATCCAA ATTTGGAAAC TGTGTATACG 
CTTTGTGAAA AAAAAGCACA GATTGCAATA GATATTAAAT CTGCAAAGCG AGAACTGAAG 
AAAGCAAGAA CAGTCCTACA AATGGATGAA CTCAAATGTC GCAAACGTGT TTTAAGAAGG 
TTGGGATTTG CTACTTCTTC TGATGTAATA GAGATGAAAG GACGAGTGGC TTGTGAGATA 
AGCAGTGCTG ATGAGCTCCT TCTAACTGAG ATGATGTTTA ATGGCCTTTT CAATGACCTT 
TCTGCAGAAC AGGCAACAGC ATTATTAAGC TGCTTTGTGT TTCAAGAGAA TTCTAGTGAG 
ATGCCCAAAT TAACAGAACA ATTAGCAGGA CCACTTCGTC AAATGCAGGA ATGTGCTAAA 
AGAATTGCAA AAGTTTCAGC AGAAGCCAAA TTGGAAATTG ATGAGGAAAC TTATCTAAGC 
TCATTTAAAC CTCACTTAAT GGATGTAGTA TATACCTGGG CAACTGGAGC TACATTTGCC 
CATATCTGCA AAATGACAGA TGTCTTTGAA GGCAGCATAA TTCGTTGTAT GAGGCGCCTG 
GAAGAATTGC TTCGACAAAT GTGTCAAGCA GCAAAAGCCA TTGGAAACAC TGAGCTGGAA 
AATAAATTTG CAGAAGGAAT CACCAAAATC AAGAGAGATA TTGTGTTTGC TGCCAGCCTC 
TACTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTREX ( NM_015360.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056175.3 Homo sapiens Mtr4 exosome RNA helicase (MTREX), mRNA.

Price & Availability↑

CloneID	OHu08849
Clone ID Related Accession (Same CDS sequence)	NM_015360.5 , NM_015360.4
Accession Version	NM_015360.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3129bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1511884800000
Organism	Homo sapiens(human)
Product	superkiller viralicidic activity 2-like 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA524147.1, BC105291.1, BX640789.1 and BC065258.1. On Jun 28, 2008 this sequence version replaced NM_015360.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC065258.1, SRR1803611.121239.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGACG CATTCGGAGA TGAGCTGTTC AGCGTGTTCG AGGGCGACTC GACCACTGCG 
GCGGGAACCA AAAAAGACAA GGAAAAGGAC AAGGGGAAAT GGAAGGGGCC TCCAGGGTCT 
GCAGACAAGG CAGGGAAACG TTTTGATGGT AAATTACAAT CAGAATCAAC TAATAATGGA 
AAAAATAAGA GAGATGTAGA TTTCGAAGGT ACAGATGAAC CCATTTTTGG AAAGAAGCCC 
AGGATAGAAG AGTCAATAAC TGAAGACTTA AGTTTGGCAG ACCTGATGCC CAGAGTCAAG 
GTACAATCAG TTGAAACTGT TGAAGGGTGT ACACATGAGG TTGCACTTCC TGCAGAAGAG 
GATTATTTAC CACTTAAACC ACGAGTTGGA AAAGCTGCTA AGGAATACCC GTTCATTCTT 
GATGCTTTTC AAAGAGAGGC CATTCAGTGT GTTGACAATA ATCAGTCTGT TCTAGTATCT 
GCACATACCT CAGCGGGAAA AACAGTATGC GCCGAGTATG CCATTGCATT GGCCTTAAGG 
GAAAAGCAGC GTGTAATATT TACCAGCCCA ATTAAGGCTC TGAGTAACCA AAAATACCGT 
GAAATGTATG AAGAATTTCA AGATGTTGGT TTGATGACTG GTGATGTTAC TATTAATCCT 
ACGGCATCTT GTCTTGTTAT GACCACAGAG ATTTTGAGAA GTATGCTTTA CAGAGGTTCC 
GAAGTTATGA GAGAAGTTGC TTGGGTTATA TTTGATGAAA TTCATTATAT GAGAGATTCA 
GAACGTGGTG TAGTATGGGA AGAAACTATT ATTTTGCTTC CTGATAACGT CCACTATGTC 
TTTCTTTCGG CTACTATTCC AAATGCCCGA CAGTTTGCTG AATGGATTTG CCATTTACAT 
AAACAGCCTT GTCATGTTAT TTACACAGAT TATCGGCCCA CTCCATTGCA ACACTACATT 
TTTCCAGCAG GGGGAGATGG CCTGCATCTT GTGGTTGATG AAAATGGTGA CTTCAGAGAA 
GATAATTTTA ATACTGCAAT GCAAGTGCTT CGAGATGCAG GTGATTTGGC CAAAGGAGAC 
CAGAAAGGGC GGAAAGGAGG AACAAAAGGA CCATCAAATG TTTTCAAAAT TGTGAAGATG 
ATTATGGAAA GAAATTTCCA ACCTGTGATT ATTTTCAGTT TTAGTAAGAA AGATTGTGAA 
GCCTATGCAC TTCAAATGAC CAAATTAGAT TTCAACACAG ATGAAGAAAA GAAGATGGTT 
GAAGAAGTAT TCAGTAATGC AATTGATTGC TTATCCGATG AAGATAAAAA ACTCCCTCAG 
GTAGAACATG TACTTCCTCT TTTGAAGAGG GGAATTGGTA TTCACCATGG TGGTTTACTT 
CCTATTTTGA AAGAAACTAT AGAAATTCTC TTTTCTGAAG GATTGATAAA GGCCTTATTT 
GCCACGGAGA CCTTTGCTAT GGGAATTAAC ATGCCAGCTA GAACTGTTTT ATTTACAAAT 
GCCCGCAAAT TTGATGGGAA GGATTTCCGA TGGATTTCTT CTGGTGAATA CATTCAGATG 
TCTGGTCGTG CTGGAAGGAG AGGAATGGAT GATAGAGGAA TTGTAATTCT TATGGTAGAT 
GAAAAGATGA GCCCAACAAT TGGAAAACAA TTACTTAAGG GCTCCGCTGA TCCTCTAAAT 
AGTGCTTTCC ATTTGACCTA CAACATGGTT TTGAACTTAC TACGTGTAGA AGAAATTAAT 
CCTGAGTACA TGTTGGAAAA ATCCTTCTAC CAGTTTCAGC ATTATAGAGC AATTCCAGGA 
GTAGTAGAGA AGGTAAAGAA TTCAGAAGAA CAGTATAATA AAATAGTAAT TCCCAATGAA 
GAAAGTGTGG TTATCTATTA TAAGATTAGA CAGCAGCTTG CCAAATTGGG TAAAGAAATT 
GAAGAATATA TTCACAAACC AAAATACTGC TTACCTTTTC TACAACCAGG TCGTTTGGTA 
AAGGTAAAGA ATGAAGGAGA TGACTTTGGC TGGGGAGTAG TGGTGAATTT CTCAAAAAAG 
TCAAATGTTA AGCCTAACTC TGGTGAACTG GATCCTTTGT ATGTAGTAGA AGTACTTCTG 
CGCTGTAGCA AAGAGAGCTT GAAAAATTCA GCTACAGAAG CTGCAAAACC AGCTAAACCT 
GATGAGAAAG GAGAGATGCA GGTTGTCCCA GTTTTGGTGC ATCTCCTGTC TGCTATCAGC 
AGTGTTAGGC TTTACATTCC TAAAGACCTT CGGCCGGTGG ACAATAGACA GAGTGTTTTA 
AAATCAATAC AGGAAGTTCA GAAACGTTTT CCTGACGGCA TCCCCTTATT AGACCCTATT 
GATGATATGG GCATTCAAGA TCAAGGGCTG AAAAAAGTCA TTCAGAAAGT AGAAGCTTTT 
GAGCATCGAA TGTATTCTCA TCCACTTCAC AATGATCCAA ATTTGGAAAC TGTGTATACG 
CTTTGTGAAA AAAAAGCACA GATTGCAATA GATATTAAAT CTGCAAAGCG AGAACTGAAG 
AAAGCAAGAA CAGTCCTACA AATGGATGAA CTCAAATGTC GCAAACGTGT TTTAAGAAGG 
TTGGGATTTG CTACTTCTTC TGATGTAATA GAGATGAAAG GACGAGTGGC TTGTGAGATA 
AGCAGTGCTG ATGAGCTCCT TCTAACTGAG ATGATGTTTA ATGGCCTTTT CAATGACCTT 
TCTGCAGAAC AGGCAACAGC ATTATTAAGC TGCTTTGTGT TTCAAGAGAA TTCTAGTGAG 
ATGCCCAAAT TAACAGAACA ATTAGCAGGA CCACTTCGTC AAATGCAGGA ATGTGCTAAA 
AGAATTGCAA AAGTTTCAGC AGAAGCCAAA TTGGAAATTG ATGAGGAAAC TTATCTAAGC 
TCATTTAAAC CTCACTTAAT GGATGTAGTA TATACCTGGG CAACTGGAGC TACATTTGCC 
CATATCTGCA AAATGACAGA TGTCTTTGAA GGCAGCATAA TTCGTTGTAT GAGGCGCCTG 
GAAGAATTGC TTCGACAAAT GTGTCAAGCA GCAAAAGCCA TTGGAAACAC TGAGCTGGAA 
AATAAATTTG CAGAAGGAAT CACCAAAATC AAGAGAGATA TTGTGTTTGC TGCCAGCCTC 
TACTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056175.3
CDS	267..3395
Translation	MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLYL

Target ORF information:

RefSeq Version	NM_015360.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Mtr4 exosome RNA helicase (MTREX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015360.4

ORF Insert Sequence:

ATGGCGGACG CATTCGGAGA TGAGCTGTTC AGCGTGTTCG AGGGCGACTC GACCACTGCG 
GCGGGAACCA AAAAAGACAA GGAAAAGGAC AAGGGGAAAT GGAAGGGGCC TCCAGGGTCT 
GCAGACAAGG CAGGGAAACG TTTTGATGGT AAATTACAAT CAGAATCAAC TAATAATGGA 
AAAAATAAGA GAGATGTAGA TTTCGAAGGT ACAGATGAAC CCATTTTTGG AAAGAAGCCC 
AGGATAGAAG AGTCAATAAC TGAAGACTTA AGTTTGGCAG ACCTGATGCC CAGAGTCAAG 
GTACAATCAG TTGAAACTGT TGAAGGGTGT ACACATGAGG TTGCACTTCC TGCAGAAGAG 
GATTATTTAC CACTTAAACC ACGAGTTGGA AAAGCTGCTA AGGAATACCC GTTCATTCTT 
GATGCTTTTC AAAGAGAGGC CATTCAGTGT GTTGACAATA ATCAGTCTGT TCTAGTATCT 
GCACATACCT CAGCGGGAAA AACAGTATGC GCCGAGTATG CCATTGCATT GGCCTTAAGG 
GAAAAGCAGC GTGTAATATT TACCAGCCCA ATTAAGGCTC TGAGTAACCA AAAATACCGT 
GAAATGTATG AAGAATTTCA AGATGTTGGT TTGATGACTG GTGATGTTAC TATTAATCCT 
ACGGCATCTT GTCTTGTTAT GACCACAGAG ATTTTGAGAA GTATGCTTTA CAGAGGTTCC 
GAAGTTATGA GAGAAGTTGC TTGGGTTATA TTTGATGAAA TTCATTATAT GAGAGATTCA 
GAACGTGGTG TAGTATGGGA AGAAACTATT ATTTTGCTTC CTGATAACGT CCACTATGTC 
TTTCTTTCGG CTACTATTCC AAATGCCCGA CAGTTTGCTG AATGGATTTG CCATTTACAT 
AAACAGCCTT GTCATGTTAT TTACACAGAT TATCGGCCCA CTCCATTGCA ACACTACATT 
TTTCCAGCAG GGGGAGATGG CCTGCATCTT GTGGTTGATG AAAATGGTGA CTTCAGAGAA 
GATAATTTTA ATACTGCAAT GCAAGTGCTT CGAGATGCAG GTGATTTGGC CAAAGGAGAC 
CAGAAAGGGC GGAAAGGAGG AACAAAAGGA CCATCAAATG TTTTCAAAAT TGTGAAGATG 
ATTATGGAAA GAAATTTCCA ACCTGTGATT ATTTTCAGTT TTAGTAAGAA AGATTGTGAA 
GCCTATGCAC TTCAAATGAC CAAATTAGAT TTCAACACAG ATGAAGAAAA GAAGATGGTT 
GAAGAAGTAT TCAGTAATGC AATTGATTGC TTATCCGATG AAGATAAAAA ACTCCCTCAG 
GTAGAACATG TACTTCCTCT TTTGAAGAGG GGAATTGGTA TTCACCATGG TGGTTTACTT 
CCTATTTTGA AAGAAACTAT AGAAATTCTC TTTTCTGAAG GATTGATAAA GGCCTTATTT 
GCCACGGAGA CCTTTGCTAT GGGAATTAAC ATGCCAGCTA GAACTGTTTT ATTTACAAAT 
GCCCGCAAAT TTGATGGGAA GGATTTCCGA TGGATTTCTT CTGGTGAATA CATTCAGATG 
TCTGGTCGTG CTGGAAGGAG AGGAATGGAT GATAGAGGAA TTGTAATTCT TATGGTAGAT 
GAAAAGATGA GCCCAACAAT TGGAAAACAA TTACTTAAGG GCTCCGCTGA TCCTCTAAAT 
AGTGCTTTCC ATTTGACCTA CAACATGGTT TTGAACTTAC TACGTGTAGA AGAAATTAAT 
CCTGAGTACA TGTTGGAAAA ATCCTTCTAC CAGTTTCAGC ATTATAGAGC AATTCCAGGA 
GTAGTAGAGA AGGTAAAGAA TTCAGAAGAA CAGTATAATA AAATAGTAAT TCCCAATGAA 
GAAAGTGTGG TTATCTATTA TAAGATTAGA CAGCAGCTTG CCAAATTGGG TAAAGAAATT 
GAAGAATATA TTCACAAACC AAAATACTGC TTACCTTTTC TACAACCAGG TCGTTTGGTA 
AAGGTAAAGA ATGAAGGAGA TGACTTTGGC TGGGGAGTAG TGGTGAATTT CTCAAAAAAG 
TCAAATGTTA AGCCTAACTC TGGTGAACTG GATCCTTTGT ATGTAGTAGA AGTACTTCTG 
CGCTGTAGCA AAGAGAGCTT GAAAAATTCA GCTACAGAAG CTGCAAAACC AGCTAAACCT 
GATGAGAAAG GAGAGATGCA GGTTGTCCCA GTTTTGGTGC ATCTCCTGTC TGCTATCAGC 
AGTGTTAGGC TTTACATTCC TAAAGACCTT CGGCCGGTGG ACAATAGACA GAGTGTTTTA 
AAATCAATAC AGGAAGTTCA GAAACGTTTT CCTGACGGCA TCCCCTTATT AGACCCTATT 
GATGATATGG GCATTCAAGA TCAAGGGCTG AAAAAAGTCA TTCAGAAAGT AGAAGCTTTT 
GAGCATCGAA TGTATTCTCA TCCACTTCAC AATGATCCAA ATTTGGAAAC TGTGTATACG 
CTTTGTGAAA AAAAAGCACA GATTGCAATA GATATTAAAT CTGCAAAGCG AGAACTGAAG 
AAAGCAAGAA CAGTCCTACA AATGGATGAA CTCAAATGTC GCAAACGTGT TTTAAGAAGG 
TTGGGATTTG CTACTTCTTC TGATGTAATA GAGATGAAAG GACGAGTGGC TTGTGAGATA 
AGCAGTGCTG ATGAGCTCCT TCTAACTGAG ATGATGTTTA ATGGCCTTTT CAATGACCTT 
TCTGCAGAAC AGGCAACAGC ATTATTAAGC TGCTTTGTGT TTCAAGAGAA TTCTAGTGAG 
ATGCCCAAAT TAACAGAACA ATTAGCAGGA CCACTTCGTC AAATGCAGGA ATGTGCTAAA 
AGAATTGCAA AAGTTTCAGC AGAAGCCAAA TTGGAAATTG ATGAGGAAAC TTATCTAAGC 
TCATTTAAAC CTCACTTAAT GGATGTAGTA TATACCTGGG CAACTGGAGC TACATTTGCC 
CATATCTGCA AAATGACAGA TGTCTTTGAA GGCAGCATAA TTCGTTGTAT GAGGCGCCTG 
GAAGAATTGC TTCGACAAAT GTGTCAAGCA GCAAAAGCCA TTGGAAACAC TGAGCTGGAA 
AATAAATTTG CAGAAGGAAT CACCAAAATC AAGAGAGATA TTGTGTTTGC TGCCAGCCTC 
TACTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
Nature communications10(1)3393(2019 07)
Lingaraju M,Johnsen D,Schlundt A,Langer LM,Basquin J,Sattler M,Heick Jensen T,Falk S,Conti E

NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Genes & development33(9-10)536-549(2019 05)
Wang J,Chen J,Wu G,Zhang H,Du X,Chen S,Zhang L,Wang K,Fan J,Gao S,Wu X,Zhang S,Kuai B,Zhao P,Chi B,Wang L,Li G,Wong CCL,Zhou Y,Li J,Yun C,Cheng H

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.
Molecular cell74(2)254-267.e10(2019 04)
Bugai A,Quaresma AJC,Friedel CC,Lenasi T,Düster R,Sibley CR,Fujinaga K,Kukanja P,Hennig T,Blasius M,Geyer M,Ule J,Dölken L,Barborič M

Distinct and evolutionary conserved structural features of the human nuclear exosome complex.
eLife7(2018 07)
Gerlach P,Schuller JM,Bonneau F,Basquin J,Reichelt P,Falk S,Conti E

Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.
Cell173(7)1663-1677.e21(2018 06)
Weick EM,Puno MR,Januszyk K,Zinder JC,DiMattia MA,Lima CD

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MTREX cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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