HEPACAM cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HEPACAM
Entrez Gene ID	220296
Full Name	hepatic and glial cell adhesion molecule
Synonyms	GlialCAM,MLC2A,MLC2B
General protein information	Preferred Names hepatic and glial cell adhesion molecule Names hepatocyte cell adhesion molecule protein hepaCAM
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q24.2
Summary	The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011].
Disorder MIM:	611642
Disorder Html:	Megalencephalic leukoencephalopathy with subcortical cysts 2A, 613925 (3); Megalencephalic leukoencephalopathy with subcortical cysts 2B, remitting, with or without mental retardation, 613926 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005271449.2	XP_005271506.1	hepatocyte cell adhesion molecule isoform X2
NM_152722.4	NP_689935.2	hepatocyte cell adhesion molecule precursor
NM_152722.5	NP_689935.2	hepatocyte cell adhesion molecule precursor
XM_017017361.1	XP_016872850.1	hepatocyte cell adhesion molecule isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HEPACAM	NP_001026929.2
Mus musculus (house mouse)	Hepacam	NP_780398.2
Xenopus tropicalis (tropical clawed frog)	hepacam	XP_002937565.2
Homo sapiens (human)	HEPACAM	NP_689935.2
Pan troglodytes (chimpanzee)	HEPACAM	XP_522240.2
Canis lupus familiaris (dog)	HEPACAM	XP_005619666.1
Gallus gallus (chicken)	HEPACAM	XP_425793.4
Danio rerio (zebrafish)	LOC100333891	XP_002666419.2
Rattus norvegicus (Norway rat)	RGD1306811	XP_002729937.2
Macaca mulatta (Rhesus monkey)	HEPACAM	XP_001106985.2

Gene Ontology
Bibliography

Related articles in PubMed

HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain.
Deng Q, Luo L, Quan Z, Liu N, Du Z, Sun W, Luo C, Wu X
Molecular medicine reports19(3)2115-2124(2019 Mar)

HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro.
Du Z, Li L, Sun W, Wang X, Zhang Y, Chen Z, Yuan M, Quan Z, Liu N, Hao Y, Li T, Wang J, Luo C, Wu X
International journal of oncology53(1)99-112(2018 Jul)

Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits the Proliferation, Migration, and Invasion in Colorectal Cancer Cells.
Geng HT, Cao RJ, Cheng L, Liu CY
Oncology research25(7)1039-1046(2017 Aug)

Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway.
Tang M, Zhao Y, Liu N, Chen E, Quan Z, Wu X, Luo C
Journal of cancer research and clinical oncology143(5)793-805(2017 May)

Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b.
Quan Z, He Y, Luo C, Xia Y, Zhao Y, Liu N, Wu X
Cellular signalling3248-58(2017 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HEPACAM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HEPACAM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu45671	XM_005271449.2 Latest version!	Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu92036	XM_017017361.1 Latest version!	Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu25834	NM_152722.5 Latest version!	Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu25834	NM_152722.4	Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HEPACAM ( XM_005271449.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005271506.1 Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu45671
Clone ID Related Accession (Same CDS sequence)	XM_005271449.2
Accession Version	XM_005271449.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	hepatocyte cell adhesion molecule isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005271449.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAGAG AAAGGGGAGC CCTGTCCAGA GCCTCCAGGG CCCTGCGCCT TGCTCCTTTT 
GTCTACCTTC TTCTGATCCA GACAGACCCC CTGGAGGGGG TGAACATCAC CAGCCCCGTG 
CGCCTGATCC ATGGCACCGT GGGGAAGTCG GCTCTGCTTT CTGTGCAGTA CAGCAGTACC 
AGCAGCGACA GGCCTGTAGT GAAGTGGCAG CTGAAGCGGG ACAAGCCAGT GACCGTGGTG 
CAGTCCATTG GCACAGAGGT CATCGGCACC CTGCGGCCTG ACTATCGAGA CCGTATCCGA 
CTCTTTGAAA ATGGCTCCCT GCTTCTCAGC GACCTGCAGC TGGCCGATGA GGGCACCTAT 
GAGGTCGAGA TCTCCATCAC CGACGACACC TTCACTGGGG AGAAGACCAT CAACCTTACT 
GTAGATGTGC CCATTTCGAG GCCACAGGTG TTGGTGGCTT CAACCACTGT GCTGGAGCTC 
AGCGAGGCCT TCACCTTGAA CTGCTCACAT GAGAATGGCA CCAAGCCCAG CTACACCTGG 
CTGAAGGATG GCAAGCCCCT CCTCAATGAC TCGAGAATGC TCCTGTCCCC CGACCAAAAG 
GTGCTCACCA TCACCCGCGT GCTCATGGAG GATGACGACC TGTACAGCTG CATGGTGGAG 
AACCCCATCA GCCAGGGCCG CAGCCTGCCT GTCAAGATCA CCGTATACAG AAGAAGCTCC 
CTTTACATCA TCTTGTCTAC AGGAGGCATC TTCCTCCTTG TGACCTTGGT GACAGTCTGT 
GCCTGCTGGA AACCCTCCAA AAGGAAACAG AAGAAGCTAG AAAAGCAAAA CTCCCTGGAA 
TACATGGATC AGAATGATGA CCGCCTGAAA CCAGAAGACA CCCTCCCTCG AAGTGGTGAG 
CAGGAACGGA AGAACCCCAT GGCACTCTAT ATCCTGAAGG ACAAGGACTC CCCGGAGACC 
GAGGAGAACC CGGCCCCGGA GCCTCGAAGC GCGACGGAGC CCGGCCCGCC CGGCTACTCC 
GTGTCTCCCG CCGTGCCCGG CCGCTCGCCG GGGCTGCCCA TCCGCTCTGC CCGCCGCTAC 
CCGCGCTCCC CAGCGCGCTC CCCAGCCACC GGCCGGACAC ACTCGTCGCC GCCCAGGGCC 
CCGAGCTCGC CCGGCCGCTC GCGCAGCGCC TCGCGCACAC TGCGGACTGC GGGCGTGCAC 
ATAATCCGCG AGCAAGACGA GGCCGGCCCG GTGGAGATCA GCGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005271506.1
CDS	407..1654
Translation	MKRERGALSRASRALRLAPFVYLLLIQTDPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDRPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLEKQNSLEYMDQNDDRLKPEDTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSASRTLRTAGVHIIREQDEAGPVEISA

Target ORF information:

RefSeq Version	XM_005271449.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005271449.2

ORF Insert Sequence:

ATGAAGAGAG AAAGGGGAGC CCTGTCCAGA GCCTCCAGGG CCCTGCGCCT TGCTCCTTTT 
GTCTACCTTC TTCTGATCCA GACAGACCCC CTGGAGGGGG TGAACATCAC CAGCCCCGTG 
CGCCTGATCC ATGGCACCGT GGGGAAGTCG GCTCTGCTTT CTGTGCAGTA CAGCAGTACC 
AGCAGCGACA GGCCTGTAGT GAAGTGGCAG CTGAAGCGGG ACAAGCCAGT GACCGTGGTG 
CAGTCCATTG GCACAGAGGT CATCGGCACC CTGCGGCCTG ACTATCGAGA CCGTATCCGA 
CTCTTTGAAA ATGGCTCCCT GCTTCTCAGC GACCTGCAGC TGGCCGATGA GGGCACCTAT 
GAGGTCGAGA TCTCCATCAC CGACGACACC TTCACTGGGG AGAAGACCAT CAACCTTACT 
GTAGATGTGC CCATTTCGAG GCCACAGGTG TTGGTGGCTT CAACCACTGT GCTGGAGCTC 
AGCGAGGCCT TCACCTTGAA CTGCTCACAT GAGAATGGCA CCAAGCCCAG CTACACCTGG 
CTGAAGGATG GCAAGCCCCT CCTCAATGAC TCGAGAATGC TCCTGTCCCC CGACCAAAAG 
GTGCTCACCA TCACCCGCGT GCTCATGGAG GATGACGACC TGTACAGCTG CATGGTGGAG 
AACCCCATCA GCCAGGGCCG CAGCCTGCCT GTCAAGATCA CCGTATACAG AAGAAGCTCC 
CTTTACATCA TCTTGTCTAC AGGAGGCATC TTCCTCCTTG TGACCTTGGT GACAGTCTGT 
GCCTGCTGGA AACCCTCCAA AAGGAAACAG AAGAAGCTAG AAAAGCAAAA CTCCCTGGAA 
TACATGGATC AGAATGATGA CCGCCTGAAA CCAGAAGACA CCCTCCCTCG AAGTGGTGAG 
CAGGAACGGA AGAACCCCAT GGCACTCTAT ATCCTGAAGG ACAAGGACTC CCCGGAGACC 
GAGGAGAACC CGGCCCCGGA GCCTCGAAGC GCGACGGAGC CCGGCCCGCC CGGCTACTCC 
GTGTCTCCCG CCGTGCCCGG CCGCTCGCCG GGGCTGCCCA TCCGCTCTGC CCGCCGCTAC 
CCGCGCTCCC CAGCGCGCTC CCCAGCCACC GGCCGGACAC ACTCGTCGCC GCCCAGGGCC 
CCGAGCTCGC CCGGCCGCTC GCGCAGCGCC TCGCGCACAC TGCGGACTGC GGGCGTGCAC 
ATAATCCGCG AGCAAGACGA GGCCGGCCCG GTGGAGATCA GCGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEPACAM ( XM_017017361.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016872850.1 Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu92036
Clone ID Related Accession (Same CDS sequence)	XM_017017361.1
Accession Version	XM_017017361.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	hepatocyte cell adhesion molecule isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAGAG AAAGGGGAGC CCTGTCCAGA GCCTCCAGGG CCCTGCGCCT TGCTCCTTTT 
GTCTACCTTC TTCTGATCCA GACAGACCCC CTGGAGGGGG TGAACATCAC CAGCCCCGTG 
CGCCTGATCC ATGGCACCGT GGGGAAGTCG GCTCTGCTTT CTGTGCAGTA CAGCAGTACC 
AGCAGCGACA GGCCTGTAGT GAAGTGGCAG CTGAAGCGGG ACAAGCCAGT GACCGTGGTG 
CAGTCCATTG GCACAGAGGT CATCGGCACC CTGCGGCCTG ACTATCGAGA CCGTATCCGA 
CTCTTTGAAA ATGGCTCCCT GCTTCTCAGC GACCTGCAGC TGGCCGATGA GGGCACCTAT 
GAGGTCGAGA TCTCCATCAC CGACGACACC TTCACTGGGG AGAAGACCAT CAACCTTACT 
GTAGATGTGC CCATTTCGAG GCCACAGGTG TTGGTGGCTT CAACCACTGT GCTGGAGCTC 
AGCGAGGCCT TCACCTTGAA CTGCTCACAT GAGAATGGCA CCAAGCCCAG CTACACCTGG 
CTGAAGGATG GCAAGCCCCT CCTCAATGAC TCGAGAATGC TCCTGTCCCC CGACCAAAAG 
GTGCTCACCA TCACCCGCGT GCTCATGGAG GATGACGACC TGTACAGCTG CATGGTGGAG 
AACCCCATCA GCCAGGGCCG CAGCCTGCCT GTCAAGATCA CCGTATACAG AAGAAGCTCC 
CTTTACATCA TCTTGTCTAC AGGAGGCATC TTCCTCCTTG TGACCTTGGT GACAGTCTGT 
GCCTGCTGGA AACCCTCCAA AAGGAAACAG AAGAAGCTAG AAAAGCAAAA CTCCCTGGAA 
TACATGGATC AGAATGATGA CCGCCTGAAA CCAGAAGGTG AGCTCCCAGC CACCCAATCA 
CCCATCCCAT CAACAATCAG ATCAGTGGGC TGCTGGGAAA AGGCAGAACT GGGCGACAAG 
GAAAACAGCT CTGCAGGGAC CCTTCCCCCA CCAACTGCAC GAAGACTGCA GAGGAGGGAA 
AGGTTTGGCC AAGCAGACAC CCTCCCTCGA AGTGGTGAGC AGGAACGGAA GAACCCCATG 
GCACTCTATA TCCTGAAGGA CAAGGACTCC CCGGAGACCG AGGAGAACCC GGCCCCGGAG 
CCTCGAAGCG CGACGGAGCC CGGCCCGCCC GGCTACTCCG TGTCTCCCGC CGTGCCCGGC 
CGCTCGCCGG GGCTGCCCAT CCGCTCTGCC CGCCGCTACC CGCGCTCCCC AGCGCGCTCC 
CCAGCCACCG GCCGGACACA CTCGTCGCCG CCCAGGGCCC CGAGCTCGCC CGGCCGCTCG 
CGCAGCGCCT CGCGCACACT GCGGACTGCG GGCGTGCACA TAATCCGCGA GCAAGACGAG 
GCCGGCCCGG TGGAGATCAG CGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016872850.1
CDS	407..1813
Translation	MKRERGALSRASRALRLAPFVYLLLIQTDPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDRPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLEKQNSLEYMDQNDDRLKPEGELPATQSPIPSTIRSVGCWEKAELGDKENSSAGTLPPPTARRLQRRERFGQADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSASRTLRTAGVHIIREQDEAGPVEISA

Target ORF information:

RefSeq Version	XM_017017361.1
Organism	Homo sapiens(human)
Definition	Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017017361.1

ORF Insert Sequence:

ATGAAGAGAG AAAGGGGAGC CCTGTCCAGA GCCTCCAGGG CCCTGCGCCT TGCTCCTTTT 
GTCTACCTTC TTCTGATCCA GACAGACCCC CTGGAGGGGG TGAACATCAC CAGCCCCGTG 
CGCCTGATCC ATGGCACCGT GGGGAAGTCG GCTCTGCTTT CTGTGCAGTA CAGCAGTACC 
AGCAGCGACA GGCCTGTAGT GAAGTGGCAG CTGAAGCGGG ACAAGCCAGT GACCGTGGTG 
CAGTCCATTG GCACAGAGGT CATCGGCACC CTGCGGCCTG ACTATCGAGA CCGTATCCGA 
CTCTTTGAAA ATGGCTCCCT GCTTCTCAGC GACCTGCAGC TGGCCGATGA GGGCACCTAT 
GAGGTCGAGA TCTCCATCAC CGACGACACC TTCACTGGGG AGAAGACCAT CAACCTTACT 
GTAGATGTGC CCATTTCGAG GCCACAGGTG TTGGTGGCTT CAACCACTGT GCTGGAGCTC 
AGCGAGGCCT TCACCTTGAA CTGCTCACAT GAGAATGGCA CCAAGCCCAG CTACACCTGG 
CTGAAGGATG GCAAGCCCCT CCTCAATGAC TCGAGAATGC TCCTGTCCCC CGACCAAAAG 
GTGCTCACCA TCACCCGCGT GCTCATGGAG GATGACGACC TGTACAGCTG CATGGTGGAG 
AACCCCATCA GCCAGGGCCG CAGCCTGCCT GTCAAGATCA CCGTATACAG AAGAAGCTCC 
CTTTACATCA TCTTGTCTAC AGGAGGCATC TTCCTCCTTG TGACCTTGGT GACAGTCTGT 
GCCTGCTGGA AACCCTCCAA AAGGAAACAG AAGAAGCTAG AAAAGCAAAA CTCCCTGGAA 
TACATGGATC AGAATGATGA CCGCCTGAAA CCAGAAGGTG AGCTCCCAGC CACCCAATCA 
CCCATCCCAT CAACAATCAG ATCAGTGGGC TGCTGGGAAA AGGCAGAACT GGGCGACAAG 
GAAAACAGCT CTGCAGGGAC CCTTCCCCCA CCAACTGCAC GAAGACTGCA GAGGAGGGAA 
AGGTTTGGCC AAGCAGACAC CCTCCCTCGA AGTGGTGAGC AGGAACGGAA GAACCCCATG 
GCACTCTATA TCCTGAAGGA CAAGGACTCC CCGGAGACCG AGGAGAACCC GGCCCCGGAG 
CCTCGAAGCG CGACGGAGCC CGGCCCGCCC GGCTACTCCG TGTCTCCCGC CGTGCCCGGC 
CGCTCGCCGG GGCTGCCCAT CCGCTCTGCC CGCCGCTACC CGCGCTCCCC AGCGCGCTCC 
CCAGCCACCG GCCGGACACA CTCGTCGCCG CCCAGGGCCC CGAGCTCGCC CGGCCGCTCG 
CGCAGCGCCT CGCGCACACT GCGGACTGCG GGCGTGCACA TAATCCGCGA GCAAGACGAG 
GCCGGCCCGG TGGAGATCAG CGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEPACAM ( NM_152722.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689935.2 Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), mRNA.

Price & Availability↑

CloneID	OHu25834
Clone ID Related Accession (Same CDS sequence)	NM_152722.4 , NM_152722.5
Accession Version	NM_152722.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512403200000
Organism	Homo sapiens(human)
Product	hepatocyte cell adhesion molecule precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA239226.1, BC113562.1, AY047587.1 and BC037810.1. This sequence is a reference standard in the RefSeqGene project. On Jan 11, 2007 this sequence version replaced NM_152722.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY047587.1, BC104831.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGAG AAAGGGGAGC CCTGTCCAGA GCCTCCAGGG CCCTGCGCCT TGCTCCTTTT 
GTCTACCTTC TTCTGATCCA GACAGACCCC CTGGAGGGGG TGAACATCAC CAGCCCCGTG 
CGCCTGATCC ATGGCACCGT GGGGAAGTCG GCTCTGCTTT CTGTGCAGTA CAGCAGTACC 
AGCAGCGACA GGCCTGTAGT GAAGTGGCAG CTGAAGCGGG ACAAGCCAGT GACCGTGGTG 
CAGTCCATTG GCACAGAGGT CATCGGCACC CTGCGGCCTG ACTATCGAGA CCGTATCCGA 
CTCTTTGAAA ATGGCTCCCT GCTTCTCAGC GACCTGCAGC TGGCCGATGA GGGCACCTAT 
GAGGTCGAGA TCTCCATCAC CGACGACACC TTCACTGGGG AGAAGACCAT CAACCTTACT 
GTAGATGTGC CCATTTCGAG GCCACAGGTG TTGGTGGCTT CAACCACTGT GCTGGAGCTC 
AGCGAGGCCT TCACCTTGAA CTGCTCACAT GAGAATGGCA CCAAGCCCAG CTACACCTGG 
CTGAAGGATG GCAAGCCCCT CCTCAATGAC TCGAGAATGC TCCTGTCCCC CGACCAAAAG 
GTGCTCACCA TCACCCGCGT GCTCATGGAG GATGACGACC TGTACAGCTG CATGGTGGAG 
AACCCCATCA GCCAGGGCCG CAGCCTGCCT GTCAAGATCA CCGTATACAG AAGAAGCTCC 
CTTTACATCA TCTTGTCTAC AGGAGGCATC TTCCTCCTTG TGACCTTGGT GACAGTCTGT 
GCCTGCTGGA AACCCTCCAA AAGGAAACAG AAGAAGCTAG AAAAGCAAAA CTCCCTGGAA 
TACATGGATC AGAATGATGA CCGCCTGAAA CCAGAAGCAG ACACCCTCCC TCGAAGTGGT 
GAGCAGGAAC GGAAGAACCC CATGGCACTC TATATCCTGA AGGACAAGGA CTCCCCGGAG 
ACCGAGGAGA ACCCGGCCCC GGAGCCTCGA AGCGCGACGG AGCCCGGCCC GCCCGGCTAC 
TCCGTGTCTC CCGCCGTGCC CGGCCGCTCG CCGGGGCTGC CCATCCGCTC TGCCCGCCGC 
TACCCGCGCT CCCCAGCGCG CTCCCCAGCC ACCGGCCGGA CACACTCGTC GCCGCCCAGG 
GCCCCGAGCT CGCCCGGCCG CTCGCGCAGC GCCTCGCGCA CACTGCGGAC TGCGGGCGTG 
CACATAATCC GCGAGCAAGA CGAGGCCGGC CCGGTGGAGA TCAGCGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689935.2
CDS	407..1657
Translation	MKRERGALSRASRALRLAPFVYLLLIQTDPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDRPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLEKQNSLEYMDQNDDRLKPEADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSASRTLRTAGVHIIREQDEAGPVEISA

Target ORF information:

RefSeq Version	NM_152722.4
Organism	Homo sapiens(human)
Definition	Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152722.4

ORF Insert Sequence:

ATGAAGAGAG AAAGGGGAGC CCTGTCCAGA GCCTCCAGGG CCCTGCGCCT TGCTCCTTTT 
GTCTACCTTC TTCTGATCCA GACAGACCCC CTGGAGGGGG TGAACATCAC CAGCCCCGTG 
CGCCTGATCC ATGGCACCGT GGGGAAGTCG GCTCTGCTTT CTGTGCAGTA CAGCAGTACC 
AGCAGCGACA GGCCTGTAGT GAAGTGGCAG CTGAAGCGGG ACAAGCCAGT GACCGTGGTG 
CAGTCCATTG GCACAGAGGT CATCGGCACC CTGCGGCCTG ACTATCGAGA CCGTATCCGA 
CTCTTTGAAA ATGGCTCCCT GCTTCTCAGC GACCTGCAGC TGGCCGATGA GGGCACCTAT 
GAGGTCGAGA TCTCCATCAC CGACGACACC TTCACTGGGG AGAAGACCAT CAACCTTACT 
GTAGATGTGC CCATTTCGAG GCCACAGGTG TTGGTGGCTT CAACCACTGT GCTGGAGCTC 
AGCGAGGCCT TCACCTTGAA CTGCTCACAT GAGAATGGCA CCAAGCCCAG CTACACCTGG 
CTGAAGGATG GCAAGCCCCT CCTCAATGAC TCGAGAATGC TCCTGTCCCC CGACCAAAAG 
GTGCTCACCA TCACCCGCGT GCTCATGGAG GATGACGACC TGTACAGCTG CATGGTGGAG 
AACCCCATCA GCCAGGGCCG CAGCCTGCCT GTCAAGATCA CCGTATACAG AAGAAGCTCC 
CTTTACATCA TCTTGTCTAC AGGAGGCATC TTCCTCCTTG TGACCTTGGT GACAGTCTGT 
GCCTGCTGGA AACCCTCCAA AAGGAAACAG AAGAAGCTAG AAAAGCAAAA CTCCCTGGAA 
TACATGGATC AGAATGATGA CCGCCTGAAA CCAGAAGCAG ACACCCTCCC TCGAAGTGGT 
GAGCAGGAAC GGAAGAACCC CATGGCACTC TATATCCTGA AGGACAAGGA CTCCCCGGAG 
ACCGAGGAGA ACCCGGCCCC GGAGCCTCGA AGCGCGACGG AGCCCGGCCC GCCCGGCTAC 
TCCGTGTCTC CCGCCGTGCC CGGCCGCTCG CCGGGGCTGC CCATCCGCTC TGCCCGCCGC 
TACCCGCGCT CCCCAGCGCG CTCCCCAGCC ACCGGCCGGA CACACTCGTC GCCGCCCAGG 
GCCCCGAGCT CGCCCGGCCG CTCGCGCAGC GCCTCGCGCA CACTGCGGAC TGCGGGCGTG 
CACATAATCC GCGAGCAAGA CGAGGCCGGC CCGGTGGAGA TCAGCGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HEPACAM ( NM_152722.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_689935.2 Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), mRNA.

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CloneID	OHu25834
Clone ID Related Accession (Same CDS sequence)	NM_152722.4 , NM_152722.5
Accession Version	NM_152722.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1566316800000
Organism	Homo sapiens(human)
Product	hepatocyte cell adhesion molecule precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA239226.1, BC113562.1, AY047587.1, BC037810.1 and AP003501.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_152722.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY047587.1, BC104831.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000298251.5/ ENSP00000298251.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGAGAG AAAGGGGAGC CCTGTCCAGA GCCTCCAGGG CCCTGCGCCT TGCTCCTTTT 
GTCTACCTTC TTCTGATCCA GACAGACCCC CTGGAGGGGG TGAACATCAC CAGCCCCGTG 
CGCCTGATCC ATGGCACCGT GGGGAAGTCG GCTCTGCTTT CTGTGCAGTA CAGCAGTACC 
AGCAGCGACA GGCCTGTAGT GAAGTGGCAG CTGAAGCGGG ACAAGCCAGT GACCGTGGTG 
CAGTCCATTG GCACAGAGGT CATCGGCACC CTGCGGCCTG ACTATCGAGA CCGTATCCGA 
CTCTTTGAAA ATGGCTCCCT GCTTCTCAGC GACCTGCAGC TGGCCGATGA GGGCACCTAT 
GAGGTCGAGA TCTCCATCAC CGACGACACC TTCACTGGGG AGAAGACCAT CAACCTTACT 
GTAGATGTGC CCATTTCGAG GCCACAGGTG TTGGTGGCTT CAACCACTGT GCTGGAGCTC 
AGCGAGGCCT TCACCTTGAA CTGCTCACAT GAGAATGGCA CCAAGCCCAG CTACACCTGG 
CTGAAGGATG GCAAGCCCCT CCTCAATGAC TCGAGAATGC TCCTGTCCCC CGACCAAAAG 
GTGCTCACCA TCACCCGCGT GCTCATGGAG GATGACGACC TGTACAGCTG CATGGTGGAG 
AACCCCATCA GCCAGGGCCG CAGCCTGCCT GTCAAGATCA CCGTATACAG AAGAAGCTCC 
CTTTACATCA TCTTGTCTAC AGGAGGCATC TTCCTCCTTG TGACCTTGGT GACAGTCTGT 
GCCTGCTGGA AACCCTCCAA AAGGAAACAG AAGAAGCTAG AAAAGCAAAA CTCCCTGGAA 
TACATGGATC AGAATGATGA CCGCCTGAAA CCAGAAGCAG ACACCCTCCC TCGAAGTGGT 
GAGCAGGAAC GGAAGAACCC CATGGCACTC TATATCCTGA AGGACAAGGA CTCCCCGGAG 
ACCGAGGAGA ACCCGGCCCC GGAGCCTCGA AGCGCGACGG AGCCCGGCCC GCCCGGCTAC 
TCCGTGTCTC CCGCCGTGCC CGGCCGCTCG CCGGGGCTGC CCATCCGCTC TGCCCGCCGC 
TACCCGCGCT CCCCAGCGCG CTCCCCAGCC ACCGGCCGGA CACACTCGTC GCCGCCCAGG 
GCCCCGAGCT CGCCCGGCCG CTCGCGCAGC GCCTCGCGCA CACTGCGGAC TGCGGGCGTG 
CACATAATCC GCGAGCAAGA CGAGGCCGGC CCGGTGGAGA TCAGCGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689935.2
CDS	42..1292
Translation	MKRERGALSRASRALRLAPFVYLLLIQTDPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDRPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLEKQNSLEYMDQNDDRLKPEADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSASRTLRTAGVHIIREQDEAGPVEISA

Target ORF information:

RefSeq Version	NM_152722.5
Organism	Homo sapiens(human)
Definition	Homo sapiens hepatic and glial cell adhesion molecule (HEPACAM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152722.5

ORF Insert Sequence:

ATGAAGAGAG AAAGGGGAGC CCTGTCCAGA GCCTCCAGGG CCCTGCGCCT TGCTCCTTTT 
GTCTACCTTC TTCTGATCCA GACAGACCCC CTGGAGGGGG TGAACATCAC CAGCCCCGTG 
CGCCTGATCC ATGGCACCGT GGGGAAGTCG GCTCTGCTTT CTGTGCAGTA CAGCAGTACC 
AGCAGCGACA GGCCTGTAGT GAAGTGGCAG CTGAAGCGGG ACAAGCCAGT GACCGTGGTG 
CAGTCCATTG GCACAGAGGT CATCGGCACC CTGCGGCCTG ACTATCGAGA CCGTATCCGA 
CTCTTTGAAA ATGGCTCCCT GCTTCTCAGC GACCTGCAGC TGGCCGATGA GGGCACCTAT 
GAGGTCGAGA TCTCCATCAC CGACGACACC TTCACTGGGG AGAAGACCAT CAACCTTACT 
GTAGATGTGC CCATTTCGAG GCCACAGGTG TTGGTGGCTT CAACCACTGT GCTGGAGCTC 
AGCGAGGCCT TCACCTTGAA CTGCTCACAT GAGAATGGCA CCAAGCCCAG CTACACCTGG 
CTGAAGGATG GCAAGCCCCT CCTCAATGAC TCGAGAATGC TCCTGTCCCC CGACCAAAAG 
GTGCTCACCA TCACCCGCGT GCTCATGGAG GATGACGACC TGTACAGCTG CATGGTGGAG 
AACCCCATCA GCCAGGGCCG CAGCCTGCCT GTCAAGATCA CCGTATACAG AAGAAGCTCC 
CTTTACATCA TCTTGTCTAC AGGAGGCATC TTCCTCCTTG TGACCTTGGT GACAGTCTGT 
GCCTGCTGGA AACCCTCCAA AAGGAAACAG AAGAAGCTAG AAAAGCAAAA CTCCCTGGAA 
TACATGGATC AGAATGATGA CCGCCTGAAA CCAGAAGCAG ACACCCTCCC TCGAAGTGGT 
GAGCAGGAAC GGAAGAACCC CATGGCACTC TATATCCTGA AGGACAAGGA CTCCCCGGAG 
ACCGAGGAGA ACCCGGCCCC GGAGCCTCGA AGCGCGACGG AGCCCGGCCC GCCCGGCTAC 
TCCGTGTCTC CCGCCGTGCC CGGCCGCTCG CCGGGGCTGC CCATCCGCTC TGCCCGCCGC 
TACCCGCGCT CCCCAGCGCG CTCCCCAGCC ACCGGCCGGA CACACTCGTC GCCGCCCAGG 
GCCCCGAGCT CGCCCGGCCG CTCGCGCAGC GCCTCGCGCA CACTGCGGAC TGCGGGCGTG 
CACATAATCC GCGAGCAAGA CGAGGCCGGC CCGGTGGAGA TCAGCGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain.
Molecular medicine reports19(3)2115-2124(2019 Mar)
Deng Q,Luo L,Quan Z,Liu N,Du Z,Sun W,Luo C,Wu X

HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro.
International journal of oncology53(1)99-112(2018 Jul)
Du Z,Li L,Sun W,Wang X,Zhang Y,Chen Z,Yuan M,Quan Z,Liu N,Hao Y,Li T,Wang J,Luo C,Wu X

Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits the Proliferation, Migration, and Invasion in Colorectal Cancer Cells.
Oncology research25(7)1039-1046(2017 Aug)
Geng HT,Cao RJ,Cheng L,Liu CY

Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway.
Journal of cancer research and clinical oncology143(5)793-805(2017 May)
Tang M,Zhao Y,Liu N,Chen E,Quan Z,Wu X,Luo C

Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b.
Cellular signalling3248-58(2017 04)
Quan Z,He Y,Luo C,Xia Y,Zhao Y,Liu N,Wu X

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HEPACAM cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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