DTX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DTX1
Entrez Gene ID	1840
Full Name	deltex E3 ubiquitin ligase 1
Synonyms	RNF140,hDx-1
General protein information	Preferred Names deltex E3 ubiquitin ligase 1 Names E3 ubiquitin-protein ligase DTX1 RING-type E3 ubiquitin transferase DTX1 deltex 1, E3 ubiquitin ligase deltex homolog 1 deltex1 hDTX1 protein deltex-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.13
Summary	Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008].
Disorder MIM:	602582

mRNA and Protein(s)

mRNA	Protein	Name
XM_011538009.1	XP_011536311.1	E3 ubiquitin-protein ligase DTX1 isoform X1
NM_004416.2	NP_004407.2	E3 ubiquitin-protein ligase DTX1
XM_011538009.2	XP_011536311.1	E3 ubiquitin-protein ligase DTX1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	DTX1	NP_004407.2
Rattus norvegicus (Norway rat)	Dtx1	XP_006249474.1
Gallus gallus (chicken)	DTX1	XP_001233994.2
Xenopus tropicalis (tropical clawed frog)	dtx1	XP_002934314.1
Bos taurus (cattle)	DTX1	NP_001192663.1
Pan troglodytes (chimpanzee)	DTX1	XP_003952356.1
Mus musculus (house mouse)	Dtx1	NP_032078.2

Gene Ontology
Bibliography

Related articles in PubMed

Immune-regulatory genes as possible modifiers of familial pityriasis rubra pilaris - lessons from a family with PRP and psoriasis.
Spoerri I, Herms S, Eytan O, Sarig O, Heinimann K, Sprecher E, Itin PH, Burger B
Journal of the European Academy of Dermatology and Venereology : JEADV32(10)e389-e392(2018 Oct)

PI5P4Kγ functions in DTX1-mediated Notch signaling.
Zheng L, Conner SD
Proceedings of the National Academy of Sciences of the United States of America115(9)E1983-E1990(2018 02)

c-FLIP is a target of the E3 ligase deltex1 in gastric cancer.
Hsu TS, Mo ST, Hsu PN, Lai MZ
Cell death & disease9(2)135(2018 01)

Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma.
Meriranta L, Pasanen A, Louhimo R, Cervera A, Alkodsi A, Autio M, Taskinen M, Rantanen V, Karjalainen-Lindsberg ML, Holte H, Delabie J, Lehtonen R, Hautaniemi S, Leppä S
Haematologica102(5)e195-e198(2017 05)

Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC.
Gaykalova DA, Zizkova V, Guo T, Tiscareno I, Wei Y, Vatapalli R, Hennessey PT, Ahn J, Danilova L, Khan Z, Bishop JA, Gutkind JS, Koch WM, Westra WH, Fertig EJ, Ochs MF, Califano JA
Oncotarget8(9)15349-15363(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DTX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DTX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13223	NM_004416.2 Latest version!	Homo sapiens deltex E3 ubiquitin ligase 1 (DTX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00
OHu13223	XM_011538009.2 Latest version!	Homo sapiens deltex E3 ubiquitin ligase 1 (DTX1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00
View Old Accession Versions >>
OHu13223	XM_011538009.1	Homo sapiens deltex 1, E3 ubiquitin ligase (DTX1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DTX1 ( XM_011538009.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011536311.1 Homo sapiens deltex 1, E3 ubiquitin ligase (DTX1), transcript variant X1, mRNA.

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CloneID	OHu13223
Clone ID Related Accession (Same CDS sequence)	XM_011538009.1 , NM_004416.2 , XM_011538009.2
Accession Version	XM_011538009.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426003200000
Organism	Homo sapiens(Human)
Product	E3 ubiquitin-protein ligase DTX1 isoform X1
Comment

ATGTCACGGC CAGGCCACGG TGGGCTGATG CCTGTGAATG GTCTGGGCTT CCCACCGCAG 
AACGTGGCCC GGGTGGTGGT GTGGGAGTGG CTGAATGAGC ACAGCCGCTG GCGGCCCTAC 
ACGGCCACCG TGTGCCACCA CATTGAGAAC GTGCTGAAGG AGGACGCTCG CGGTTCCGTG 
GTCCTGGGGC AGGTGGACGC CCAGCTTGTG CCCTACATCA TCGACCTGCA GTCCATGCAC 
CAGTTTCGCC AGGACACAGG CACCATGCGG CCCGTGCGGC GCAACTTCTA CGACCCGTCG 
TCGGCGCCGG GCAAGGGCAT CGTGTGGGAG TGGGAGAACG ACGGCGGCGC ATGGACGGCC 
TACGATATGG ACATCTGCAT CACCATCCAG AACGCCTACG AGAAGCAGCA CCCGTGGCTC 
GACCTCTCAT CGCTAGGCTT CTGCTACCTC ATCTACTTCA ACAGCATGTC GCAGATGAAC 
CGCCAGACGC GCCGGCGCCG CCGCCTGCGC CGCCGCCTGG ACCTCGCCTA CCCGCTCACC 
GTGGGCTCCA TCCCTAAGTC GCAGTCGTGG CCCGTGGGCG CCAGCTCGGG CCAGCCCTGC 
TCCTGCCAGC AGTGCCTGCT GGTCAACAGC ACGCGCGCCG CCTCCAACGC CATCCTGGCC 
TCGCAGCGCC GCAAGGCGCC CCCCGCGCCC CCGCTGCCGC CGCCGCCGCC ACCTGGAGGG 
CCTCCAGGCG CGCTTGCCGT GCGCCCCAGC GCCACCTTCA CAGGCGCCGC GCTCTGGGCA 
GCGCCCGCCG CCGGCCCCGC CGAGCCCGCG CCGCCTCCCG GGGCGCCCCC ACGGAGCCCG 
GGCGCCCCCG GCGGAGCGCG CACCCCGGGG CAGAACAACC TCAACCGGCC CGGGCCCCAG 
CGCACCACCA GCGTGAGCGC GCGCGCCTCC ATCCCGCCGG GGGTCCCCGC ACTCCCGGTG 
AAGAACTTGA ATGGTACTGG GCCGGTCCAT CCGGCCCTGG CAGGGATGAC CGGGATACTG 
CTGTGCGCGG CCGGGCTGCC CGTGTGCCTG ACGCGGGCCC CCAAGCCCAT CCTGCACCCG 
CCGCCCGTGA GCAAGAGCGA CGTGAAGCCC GTGCCTGGCG TGCCCGGGGT GTGCCGCAAG 
ACCAAGAAGA AGCACCTTAA AAAGAGTAAG AATCCCGAGG ATGTGGTTCG AAGATACATG 
CAGAAGGTGA AAAACCCACC TGATGAGGAC TGCACCATCT GCATGGAGCG ACTGGTCACA 
GCATCAGGCT ACGAGGGCGT GCTTCGGCAC AAGGGCGTGC GGCCTGAGCT CGTGGGCCGC 
CTGGGCCGCT GTGGCCACAT GTACCACCTG CTGTGCCTCG TGGCCATGTA CTCCAATGGC 
AACAAGGATG GCAGCCTGCA GTGCCCCACC TGCAAGGCCA TCTACGGGGA GAAGACGGGT 
ACGCAGCCGC CTGGGAAGAT GGAGTTCCAC CTCATCCCCC ACTCGCTGCC CGGCTTCCCT 
GATACCCAGA CCATCCGCAT CGTCTATGAC ATCCCCACAG GCATCCAGGG CCCTGAGCAC 
CCCAACCCCG GGAAGAAGTT CACCGCAAGA GGATTCCCTC GCCACTGCTA TCTACCCAAC 
AACGAGAAAG GCCGGAAGGT GCTGCGGCTG CTCATCACGG CCTGGGAGAG AAGACTCATC 
TTCACTATCG GCACGTCCAA CACCACGGGC GAGTCGGACA CCGTGGTGTG GAACGAGATC 
CACCACAAGA CCGAGTTTGG ATCCAACCTC ACGGGCCACG GCTACCCGGA CGCTAGCTAC 
CTAGACAACG TGCTGGCTGA GCTCACAGCC CAGGGCGTAT CCGAGGCTGC AGCCAAGGCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011536311.1

Translation

MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA

Target ORF information:

RefSeq Version	XM_011538009.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens deltex 1, E3 ubiquitin ligase (DTX1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011538009.1

ORF Insert Sequence:

ATGTCACGGC CAGGCCACGG TGGGCTGATG CCTGTGAATG GTCTGGGCTT CCCACCGCAG 
AACGTGGCCC GGGTGGTGGT GTGGGAGTGG CTGAATGAGC ACAGCCGCTG GCGGCCCTAC 
ACGGCCACCG TGTGCCACCA CATTGAGAAC GTGCTGAAGG AGGACGCTCG CGGTTCCGTG 
GTCCTGGGGC AGGTGGACGC CCAGCTTGTG CCCTACATCA TCGACCTGCA GTCCATGCAC 
CAGTTTCGCC AGGACACAGG CACCATGCGG CCCGTGCGGC GCAACTTCTA CGACCCGTCG 
TCGGCGCCGG GCAAGGGCAT CGTGTGGGAG TGGGAGAACG ACGGCGGCGC ATGGACGGCC 
TACGATATGG ACATCTGCAT CACCATCCAG AACGCCTACG AGAAGCAGCA CCCGTGGCTC 
GACCTCTCAT CGCTAGGCTT CTGCTACCTC ATCTACTTCA ACAGCATGTC GCAGATGAAC 
CGCCAGACGC GCCGGCGCCG CCGCCTGCGC CGCCGCCTGG ACCTCGCCTA CCCGCTCACC 
GTGGGCTCCA TCCCTAAGTC GCAGTCGTGG CCCGTGGGCG CCAGCTCGGG CCAGCCCTGC 
TCCTGCCAGC AGTGCCTGCT GGTCAACAGC ACGCGCGCCG CCTCCAACGC CATCCTGGCC 
TCGCAGCGCC GCAAGGCGCC CCCCGCGCCC CCGCTGCCGC CGCCGCCGCC ACCTGGAGGG 
CCTCCAGGCG CGCTTGCCGT GCGCCCCAGC GCCACCTTCA CAGGCGCCGC GCTCTGGGCA 
GCGCCCGCCG CCGGCCCCGC CGAGCCCGCG CCGCCTCCCG GGGCGCCCCC ACGGAGCCCG 
GGCGCCCCCG GCGGAGCGCG CACCCCGGGG CAGAACAACC TCAACCGGCC CGGGCCCCAG 
CGCACCACCA GCGTGAGCGC GCGCGCCTCC ATCCCGCCGG GGGTCCCCGC ACTCCCGGTG 
AAGAACTTGA ATGGTACTGG GCCGGTCCAT CCGGCCCTGG CAGGGATGAC CGGGATACTG 
CTGTGCGCGG CCGGGCTGCC CGTGTGCCTG ACGCGGGCCC CCAAGCCCAT CCTGCACCCG 
CCGCCCGTGA GCAAGAGCGA CGTGAAGCCC GTGCCTGGCG TGCCCGGGGT GTGCCGCAAG 
ACCAAGAAGA AGCACCTTAA AAAGAGTAAG AATCCCGAGG ATGTGGTTCG AAGATACATG 
CAGAAGGTGA AAAACCCACC TGATGAGGAC TGCACCATCT GCATGGAGCG ACTGGTCACA 
GCATCAGGCT ACGAGGGCGT GCTTCGGCAC AAGGGCGTGC GGCCTGAGCT CGTGGGCCGC 
CTGGGCCGCT GTGGCCACAT GTACCACCTG CTGTGCCTCG TGGCCATGTA CTCCAATGGC 
AACAAGGATG GCAGCCTGCA GTGCCCCACC TGCAAGGCCA TCTACGGGGA GAAGACGGGT 
ACGCAGCCGC CTGGGAAGAT GGAGTTCCAC CTCATCCCCC ACTCGCTGCC CGGCTTCCCT 
GATACCCAGA CCATCCGCAT CGTCTATGAC ATCCCCACAG GCATCCAGGG CCCTGAGCAC 
CCCAACCCCG GGAAGAAGTT CACCGCAAGA GGATTCCCTC GCCACTGCTA TCTACCCAAC 
AACGAGAAAG GCCGGAAGGT GCTGCGGCTG CTCATCACGG CCTGGGAGAG AAGACTCATC 
TTCACTATCG GCACGTCCAA CACCACGGGC GAGTCGGACA CCGTGGTGTG GAACGAGATC 
CACCACAAGA CCGAGTTTGG ATCCAACCTC ACGGGCCACG GCTACCCGGA CGCTAGCTAC 
CTAGACAACG TGCTGGCTGA GCTCACAGCC CAGGGCGTAT CCGAGGCTGC AGCCAAGGCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DTX1 ( NM_004416.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004407.2 Homo sapiens deltex E3 ubiquitin ligase 1 (DTX1), mRNA.

Price & Availability↑

CloneID	OHu13223
Clone ID Related Accession (Same CDS sequence)	XM_011538009.1 , NM_004416.2 , XM_011538009.2
Accession Version	NM_004416.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1566748800000
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase DTX1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF053700.1, BC048216.1 and BC005816.2. On Jan 28, 2004 this sequence version replaced NM_004416.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC048216.1, AF053700.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCACGGC CAGGCCACGG TGGGCTGATG CCTGTGAATG GTCTGGGCTT CCCACCGCAG 
AACGTGGCCC GGGTGGTGGT GTGGGAGTGG CTGAATGAGC ACAGCCGCTG GCGGCCCTAC 
ACGGCCACCG TGTGCCACCA CATTGAGAAC GTGCTGAAGG AGGACGCTCG CGGTTCCGTG 
GTCCTGGGGC AGGTGGACGC CCAGCTTGTG CCCTACATCA TCGACCTGCA GTCCATGCAC 
CAGTTTCGCC AGGACACAGG CACCATGCGG CCCGTGCGGC GCAACTTCTA CGACCCGTCG 
TCGGCGCCGG GCAAGGGCAT CGTGTGGGAG TGGGAGAACG ACGGCGGCGC ATGGACGGCC 
TACGATATGG ACATCTGCAT CACCATCCAG AACGCCTACG AGAAGCAGCA CCCGTGGCTC 
GACCTCTCAT CGCTAGGCTT CTGCTACCTC ATCTACTTCA ACAGCATGTC GCAGATGAAC 
CGCCAGACGC GCCGGCGCCG CCGCCTGCGC CGCCGCCTGG ACCTCGCCTA CCCGCTCACC 
GTGGGCTCCA TCCCTAAGTC GCAGTCGTGG CCCGTGGGCG CCAGCTCGGG CCAGCCCTGC 
TCCTGCCAGC AGTGCCTGCT GGTCAACAGC ACGCGCGCCG CCTCCAACGC CATCCTGGCC 
TCGCAGCGCC GCAAGGCGCC CCCCGCGCCC CCGCTGCCGC CGCCGCCGCC ACCTGGAGGG 
CCTCCAGGCG CGCTTGCCGT GCGCCCCAGC GCCACCTTCA CAGGCGCCGC GCTCTGGGCA 
GCGCCCGCCG CCGGCCCCGC CGAGCCCGCG CCGCCTCCCG GGGCGCCCCC ACGGAGCCCG 
GGCGCCCCCG GCGGAGCGCG CACCCCGGGG CAGAACAACC TCAACCGGCC CGGGCCCCAG 
CGCACCACCA GCGTGAGCGC GCGCGCCTCC ATCCCGCCGG GGGTCCCCGC ACTCCCGGTG 
AAGAACTTGA ATGGTACTGG GCCGGTCCAT CCGGCCCTGG CAGGGATGAC CGGGATACTG 
CTGTGCGCGG CCGGGCTGCC CGTGTGCCTG ACGCGGGCCC CCAAGCCCAT CCTGCACCCG 
CCGCCCGTGA GCAAGAGCGA CGTGAAGCCC GTGCCTGGCG TGCCCGGGGT GTGCCGCAAG 
ACCAAGAAGA AGCACCTTAA AAAGAGTAAG AATCCCGAGG ATGTGGTTCG AAGATACATG 
CAGAAGGTGA AAAACCCACC TGATGAGGAC TGCACCATCT GCATGGAGCG ACTGGTCACA 
GCATCAGGCT ACGAGGGCGT GCTTCGGCAC AAGGGCGTGC GGCCTGAGCT CGTGGGCCGC 
CTGGGCCGCT GTGGCCACAT GTACCACCTG CTGTGCCTCG TGGCCATGTA CTCCAATGGC 
AACAAGGATG GCAGCCTGCA GTGCCCCACC TGCAAGGCCA TCTACGGGGA GAAGACGGGT 
ACGCAGCCGC CTGGGAAGAT GGAGTTCCAC CTCATCCCCC ACTCGCTGCC CGGCTTCCCT 
GATACCCAGA CCATCCGCAT CGTCTATGAC ATCCCCACAG GCATCCAGGG CCCTGAGCAC 
CCCAACCCCG GGAAGAAGTT CACCGCAAGA GGATTCCCTC GCCACTGCTA TCTACCCAAC 
AACGAGAAAG GCCGGAAGGT GCTGCGGCTG CTCATCACGG CCTGGGAGAG AAGACTCATC 
TTCACTATCG GCACGTCCAA CACCACGGGC GAGTCGGACA CCGTGGTGTG GAACGAGATC 
CACCACAAGA CCGAGTTTGG ATCCAACCTC ACGGGCCACG GCTACCCGGA CGCTAGCTAC 
CTAGACAACG TGCTGGCTGA GCTCACAGCC CAGGGCGTAT CCGAGGCTGC AGCCAAGGCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004407.2
CDS	337..2199
Translation	MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA

Target ORF information:

RefSeq Version	NM_004416.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deltex E3 ubiquitin ligase 1 (DTX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004416.2

ORF Insert Sequence:

ATGTCACGGC CAGGCCACGG TGGGCTGATG CCTGTGAATG GTCTGGGCTT CCCACCGCAG 
AACGTGGCCC GGGTGGTGGT GTGGGAGTGG CTGAATGAGC ACAGCCGCTG GCGGCCCTAC 
ACGGCCACCG TGTGCCACCA CATTGAGAAC GTGCTGAAGG AGGACGCTCG CGGTTCCGTG 
GTCCTGGGGC AGGTGGACGC CCAGCTTGTG CCCTACATCA TCGACCTGCA GTCCATGCAC 
CAGTTTCGCC AGGACACAGG CACCATGCGG CCCGTGCGGC GCAACTTCTA CGACCCGTCG 
TCGGCGCCGG GCAAGGGCAT CGTGTGGGAG TGGGAGAACG ACGGCGGCGC ATGGACGGCC 
TACGATATGG ACATCTGCAT CACCATCCAG AACGCCTACG AGAAGCAGCA CCCGTGGCTC 
GACCTCTCAT CGCTAGGCTT CTGCTACCTC ATCTACTTCA ACAGCATGTC GCAGATGAAC 
CGCCAGACGC GCCGGCGCCG CCGCCTGCGC CGCCGCCTGG ACCTCGCCTA CCCGCTCACC 
GTGGGCTCCA TCCCTAAGTC GCAGTCGTGG CCCGTGGGCG CCAGCTCGGG CCAGCCCTGC 
TCCTGCCAGC AGTGCCTGCT GGTCAACAGC ACGCGCGCCG CCTCCAACGC CATCCTGGCC 
TCGCAGCGCC GCAAGGCGCC CCCCGCGCCC CCGCTGCCGC CGCCGCCGCC ACCTGGAGGG 
CCTCCAGGCG CGCTTGCCGT GCGCCCCAGC GCCACCTTCA CAGGCGCCGC GCTCTGGGCA 
GCGCCCGCCG CCGGCCCCGC CGAGCCCGCG CCGCCTCCCG GGGCGCCCCC ACGGAGCCCG 
GGCGCCCCCG GCGGAGCGCG CACCCCGGGG CAGAACAACC TCAACCGGCC CGGGCCCCAG 
CGCACCACCA GCGTGAGCGC GCGCGCCTCC ATCCCGCCGG GGGTCCCCGC ACTCCCGGTG 
AAGAACTTGA ATGGTACTGG GCCGGTCCAT CCGGCCCTGG CAGGGATGAC CGGGATACTG 
CTGTGCGCGG CCGGGCTGCC CGTGTGCCTG ACGCGGGCCC CCAAGCCCAT CCTGCACCCG 
CCGCCCGTGA GCAAGAGCGA CGTGAAGCCC GTGCCTGGCG TGCCCGGGGT GTGCCGCAAG 
ACCAAGAAGA AGCACCTTAA AAAGAGTAAG AATCCCGAGG ATGTGGTTCG AAGATACATG 
CAGAAGGTGA AAAACCCACC TGATGAGGAC TGCACCATCT GCATGGAGCG ACTGGTCACA 
GCATCAGGCT ACGAGGGCGT GCTTCGGCAC AAGGGCGTGC GGCCTGAGCT CGTGGGCCGC 
CTGGGCCGCT GTGGCCACAT GTACCACCTG CTGTGCCTCG TGGCCATGTA CTCCAATGGC 
AACAAGGATG GCAGCCTGCA GTGCCCCACC TGCAAGGCCA TCTACGGGGA GAAGACGGGT 
ACGCAGCCGC CTGGGAAGAT GGAGTTCCAC CTCATCCCCC ACTCGCTGCC CGGCTTCCCT 
GATACCCAGA CCATCCGCAT CGTCTATGAC ATCCCCACAG GCATCCAGGG CCCTGAGCAC 
CCCAACCCCG GGAAGAAGTT CACCGCAAGA GGATTCCCTC GCCACTGCTA TCTACCCAAC 
AACGAGAAAG GCCGGAAGGT GCTGCGGCTG CTCATCACGG CCTGGGAGAG AAGACTCATC 
TTCACTATCG GCACGTCCAA CACCACGGGC GAGTCGGACA CCGTGGTGTG GAACGAGATC 
CACCACAAGA CCGAGTTTGG ATCCAACCTC ACGGGCCACG GCTACCCGGA CGCTAGCTAC 
CTAGACAACG TGCTGGCTGA GCTCACAGCC CAGGGCGTAT CCGAGGCTGC AGCCAAGGCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DTX1 ( XM_011538009.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011536311.1 Homo sapiens deltex E3 ubiquitin ligase 1 (DTX1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu13223
Clone ID Related Accession (Same CDS sequence)	XM_011538009.1 , NM_004416.2 , XM_011538009.2
Accession Version	XM_011538009.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase DTX1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011538009.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCACGGC CAGGCCACGG TGGGCTGATG CCTGTGAATG GTCTGGGCTT CCCACCGCAG 
AACGTGGCCC GGGTGGTGGT GTGGGAGTGG CTGAATGAGC ACAGCCGCTG GCGGCCCTAC 
ACGGCCACCG TGTGCCACCA CATTGAGAAC GTGCTGAAGG AGGACGCTCG CGGTTCCGTG 
GTCCTGGGGC AGGTGGACGC CCAGCTTGTG CCCTACATCA TCGACCTGCA GTCCATGCAC 
CAGTTTCGCC AGGACACAGG CACCATGCGG CCCGTGCGGC GCAACTTCTA CGACCCGTCG 
TCGGCGCCGG GCAAGGGCAT CGTGTGGGAG TGGGAGAACG ACGGCGGCGC ATGGACGGCC 
TACGATATGG ACATCTGCAT CACCATCCAG AACGCCTACG AGAAGCAGCA CCCGTGGCTC 
GACCTCTCAT CGCTAGGCTT CTGCTACCTC ATCTACTTCA ACAGCATGTC GCAGATGAAC 
CGCCAGACGC GCCGGCGCCG CCGCCTGCGC CGCCGCCTGG ACCTCGCCTA CCCGCTCACC 
GTGGGCTCCA TCCCTAAGTC GCAGTCGTGG CCCGTGGGCG CCAGCTCGGG CCAGCCCTGC 
TCCTGCCAGC AGTGCCTGCT GGTCAACAGC ACGCGCGCCG CCTCCAACGC CATCCTGGCC 
TCGCAGCGCC GCAAGGCGCC CCCCGCGCCC CCGCTGCCGC CGCCGCCGCC ACCTGGAGGG 
CCTCCAGGCG CGCTTGCCGT GCGCCCCAGC GCCACCTTCA CAGGCGCCGC GCTCTGGGCA 
GCGCCCGCCG CCGGCCCCGC CGAGCCCGCG CCGCCTCCCG GGGCGCCCCC ACGGAGCCCG 
GGCGCCCCCG GCGGAGCGCG CACCCCGGGG CAGAACAACC TCAACCGGCC CGGGCCCCAG 
CGCACCACCA GCGTGAGCGC GCGCGCCTCC ATCCCGCCGG GGGTCCCCGC ACTCCCGGTG 
AAGAACTTGA ATGGTACTGG GCCGGTCCAT CCGGCCCTGG CAGGGATGAC CGGGATACTG 
CTGTGCGCGG CCGGGCTGCC CGTGTGCCTG ACGCGGGCCC CCAAGCCCAT CCTGCACCCG 
CCGCCCGTGA GCAAGAGCGA CGTGAAGCCC GTGCCTGGCG TGCCCGGGGT GTGCCGCAAG 
ACCAAGAAGA AGCACCTTAA AAAGAGTAAG AATCCCGAGG ATGTGGTTCG AAGATACATG 
CAGAAGGTGA AAAACCCACC TGATGAGGAC TGCACCATCT GCATGGAGCG ACTGGTCACA 
GCATCAGGCT ACGAGGGCGT GCTTCGGCAC AAGGGCGTGC GGCCTGAGCT CGTGGGCCGC 
CTGGGCCGCT GTGGCCACAT GTACCACCTG CTGTGCCTCG TGGCCATGTA CTCCAATGGC 
AACAAGGATG GCAGCCTGCA GTGCCCCACC TGCAAGGCCA TCTACGGGGA GAAGACGGGT 
ACGCAGCCGC CTGGGAAGAT GGAGTTCCAC CTCATCCCCC ACTCGCTGCC CGGCTTCCCT 
GATACCCAGA CCATCCGCAT CGTCTATGAC ATCCCCACAG GCATCCAGGG CCCTGAGCAC 
CCCAACCCCG GGAAGAAGTT CACCGCAAGA GGATTCCCTC GCCACTGCTA TCTACCCAAC 
AACGAGAAAG GCCGGAAGGT GCTGCGGCTG CTCATCACGG CCTGGGAGAG AAGACTCATC 
TTCACTATCG GCACGTCCAA CACCACGGGC GAGTCGGACA CCGTGGTGTG GAACGAGATC 
CACCACAAGA CCGAGTTTGG ATCCAACCTC ACGGGCCACG GCTACCCGGA CGCTAGCTAC 
CTAGACAACG TGCTGGCTGA GCTCACAGCC CAGGGCGTAT CCGAGGCTGC AGCCAAGGCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011536311.1
CDS	979..2841
Translation	MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA

Target ORF information:

RefSeq Version	XM_011538009.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deltex E3 ubiquitin ligase 1 (DTX1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011538009.2

ORF Insert Sequence:

ATGTCACGGC CAGGCCACGG TGGGCTGATG CCTGTGAATG GTCTGGGCTT CCCACCGCAG 
AACGTGGCCC GGGTGGTGGT GTGGGAGTGG CTGAATGAGC ACAGCCGCTG GCGGCCCTAC 
ACGGCCACCG TGTGCCACCA CATTGAGAAC GTGCTGAAGG AGGACGCTCG CGGTTCCGTG 
GTCCTGGGGC AGGTGGACGC CCAGCTTGTG CCCTACATCA TCGACCTGCA GTCCATGCAC 
CAGTTTCGCC AGGACACAGG CACCATGCGG CCCGTGCGGC GCAACTTCTA CGACCCGTCG 
TCGGCGCCGG GCAAGGGCAT CGTGTGGGAG TGGGAGAACG ACGGCGGCGC ATGGACGGCC 
TACGATATGG ACATCTGCAT CACCATCCAG AACGCCTACG AGAAGCAGCA CCCGTGGCTC 
GACCTCTCAT CGCTAGGCTT CTGCTACCTC ATCTACTTCA ACAGCATGTC GCAGATGAAC 
CGCCAGACGC GCCGGCGCCG CCGCCTGCGC CGCCGCCTGG ACCTCGCCTA CCCGCTCACC 
GTGGGCTCCA TCCCTAAGTC GCAGTCGTGG CCCGTGGGCG CCAGCTCGGG CCAGCCCTGC 
TCCTGCCAGC AGTGCCTGCT GGTCAACAGC ACGCGCGCCG CCTCCAACGC CATCCTGGCC 
TCGCAGCGCC GCAAGGCGCC CCCCGCGCCC CCGCTGCCGC CGCCGCCGCC ACCTGGAGGG 
CCTCCAGGCG CGCTTGCCGT GCGCCCCAGC GCCACCTTCA CAGGCGCCGC GCTCTGGGCA 
GCGCCCGCCG CCGGCCCCGC CGAGCCCGCG CCGCCTCCCG GGGCGCCCCC ACGGAGCCCG 
GGCGCCCCCG GCGGAGCGCG CACCCCGGGG CAGAACAACC TCAACCGGCC CGGGCCCCAG 
CGCACCACCA GCGTGAGCGC GCGCGCCTCC ATCCCGCCGG GGGTCCCCGC ACTCCCGGTG 
AAGAACTTGA ATGGTACTGG GCCGGTCCAT CCGGCCCTGG CAGGGATGAC CGGGATACTG 
CTGTGCGCGG CCGGGCTGCC CGTGTGCCTG ACGCGGGCCC CCAAGCCCAT CCTGCACCCG 
CCGCCCGTGA GCAAGAGCGA CGTGAAGCCC GTGCCTGGCG TGCCCGGGGT GTGCCGCAAG 
ACCAAGAAGA AGCACCTTAA AAAGAGTAAG AATCCCGAGG ATGTGGTTCG AAGATACATG 
CAGAAGGTGA AAAACCCACC TGATGAGGAC TGCACCATCT GCATGGAGCG ACTGGTCACA 
GCATCAGGCT ACGAGGGCGT GCTTCGGCAC AAGGGCGTGC GGCCTGAGCT CGTGGGCCGC 
CTGGGCCGCT GTGGCCACAT GTACCACCTG CTGTGCCTCG TGGCCATGTA CTCCAATGGC 
AACAAGGATG GCAGCCTGCA GTGCCCCACC TGCAAGGCCA TCTACGGGGA GAAGACGGGT 
ACGCAGCCGC CTGGGAAGAT GGAGTTCCAC CTCATCCCCC ACTCGCTGCC CGGCTTCCCT 
GATACCCAGA CCATCCGCAT CGTCTATGAC ATCCCCACAG GCATCCAGGG CCCTGAGCAC 
CCCAACCCCG GGAAGAAGTT CACCGCAAGA GGATTCCCTC GCCACTGCTA TCTACCCAAC 
AACGAGAAAG GCCGGAAGGT GCTGCGGCTG CTCATCACGG CCTGGGAGAG AAGACTCATC 
TTCACTATCG GCACGTCCAA CACCACGGGC GAGTCGGACA CCGTGGTGTG GAACGAGATC 
CACCACAAGA CCGAGTTTGG ATCCAACCTC ACGGGCCACG GCTACCCGGA CGCTAGCTAC 
CTAGACAACG TGCTGGCTGA GCTCACAGCC CAGGGCGTAT CCGAGGCTGC AGCCAAGGCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Immune-regulatory genes as possible modifiers of familial pityriasis rubra pilaris - lessons from a family with PRP and psoriasis.
Journal of the European Academy of Dermatology and Venereology : JEADV32(10)e389-e392(2018 Oct)
Spoerri I,Herms S,Eytan O,Sarig O,Heinimann K,Sprecher E,Itin PH,Burger B

PI5P4Kγ functions in DTX1-mediated Notch signaling.
Proceedings of the National Academy of Sciences of the United States of America115(9)E1983-E1990(2018 02)
Zheng L,Conner SD

c-FLIP is a target of the E3 ligase deltex1 in gastric cancer.
Cell death & disease9(2)135(2018 01)
Hsu TS,Mo ST,Hsu PN,Lai MZ

Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma.
Haematologica102(5)e195-e198(2017 05)
Meriranta L,Pasanen A,Louhimo R,Cervera A,Alkodsi A,Autio M,Taskinen M,Rantanen V,Karjalainen-Lindsberg ML,Holte H,Delabie J,Lehtonen R,Hautaniemi S,Leppä S

Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC.
Oncotarget8(9)15349-15363(2017 Feb)
Gaykalova DA,Zizkova V,Guo T,Tiscareno I,Wei Y,Vatapalli R,Hennessey PT,Ahn J,Danilova L,Khan Z,Bishop JA,Gutkind JS,Koch WM,Westra WH,Fertig EJ,Ochs MF,Califano JA

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DTX1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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