DSG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DSG2
Entrez Gene ID	1829
Full Name	desmoglein 2
Synonyms	CDHF5,HDGC
General protein information	Preferred Names desmoglein 2 Names desmoglein-2 cadherin family member 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016].
Disorder MIM:	125671
Disorder Html:	Arrhythmogenic right ventricular dysplasia 10, 610193 (3); Cardiomyopathy, dilated, 1BB, 612877 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001943.3	NP_001934.2	desmoglein-2 preproprotein
NM_001943.4	NP_001934.2	desmoglein-2 preproprotein
NM_001943.5	NP_001934.2	desmoglein-2 preproprotein
XM_024451095.1	XP_024306863.1	desmoglein-2 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	DSG2	NP_001934.2
Danio rerio (zebrafish)	LOC101882022	XP_005170207.1
Canis lupus familiaris (dog)	DSG2	XP_005622989.1
Bos taurus (cattle)	DSG2	NP_001179101.2
Mus musculus (house mouse)	Dsg2	NP_031909.2
Danio rerio (zebrafish)	si:ch73-74h11.1	XP_003200735.2
Rattus norvegicus (Norway rat)	Dsg2	XP_006254536.1
Danio rerio (zebrafish)	dsg2	NP_001243566.1
Danio rerio (zebrafish)	dsg2l	XP_005171176.1
Pan troglodytes (chimpanzee)	DSG2	XP_512079.2
Macaca mulatta (Rhesus monkey)	DSG2	XP_001098597.1
Gallus gallus (chicken)	DSG2	XP_426083.4
Xenopus tropicalis (tropical clawed frog)	dsg2	XP_002934177.2

Gene Ontology
Bibliography

Related articles in PubMed

A common indel polymorphism of the Desmoglein-2 (DSG2) is associated with sudden cardiac death in Chinese populations.
Zou Y, Zhang Q, Zhang J, Chen X, Zhou W, Yang Z, Yang Q, Yu H, Li L, He Y, Li C, Zhang S, Zhu S, Luo B, Gao Y
Forensic science international301382-387(2019 Aug)

CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement.
Vassal-Stermann E, Effantin G, Zubieta C, Burmeister W, Iseni F, Wang H, Lieber A, Schoehn G, Fender P
Nature communications10(1)1181(2019 03)

A founder homozygous DSG2 variant in East Asia results in ARVC with full penetrance and heart failure phenotype.
Chen L, Rao M, Chen X, Chen K, Ren J, Zhang N, Zhao Q, Yu W, Yuan B, Song J
International journal of cardiology274263-270(2019 Jan)

Disturbed Desmoglein-2 in the intercalated disc of pediatric patients with dilated cardiomyopathy.
Kessler EL, Nikkels PG, van Veen TA
Human pathology67101-108(2017 09)

Case reports of two pedigrees with recessive arrhythmogenic right ventricular cardiomyopathy associated with homozygous Thr335Ala variant in DSG2.
Qadri S, Anttonen O, Viikilä J, Seppälä EH, Myllykangas S, Alastalo TP, Holmström M, Heliö T, Koskenvuo JW
BMC medical genetics18(1)86(2017 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DSG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DSG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu104508	XM_024451095.1 Latest version!	Homo sapiens desmoglein 2 (DSG2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu22755	NM_001943.5 Latest version!	Homo sapiens desmoglein 2 (DSG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$384.30 $549.00
View Old Accession Versions >>
OHu22755	NM_001943.3	Homo sapiens desmoglein 2 (DSG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
OHu22755	NM_001943.4	Homo sapiens desmoglein 2 (DSG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DSG2 ( NM_001943.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001934.2 Homo sapiens desmoglein 2 (DSG2), mRNA.

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CloneID	OHu22755
Clone ID Related Accession (Same CDS sequence)	NM_001943.3 , NM_001943.4 , NM_001943.5
Accession Version	NM_001943.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426262400000
Organism	Homo sapiens(Human)
Product	desmoglein-2 preproprotein
Comment

ATGGCGCGGA GCCCGGGACG CGCGTACGCC CTGCTGCTTC TCCTGATCTG CTTTAACGTT 
GGAAGTGGAC TTCACTTACA GGTCTTAAGC ACAAGAAATG AAAATAAGCT GCTTCCTAAA 
CATCCTCATT TAGTGCGGCA AAAGCGCGCC TGGATCACCG CCCCCGTGGC TCTTCGGGAG 
GGAGAGGATC TGTCCAAGAA GAATCCAATT GCCAAGATAC ATTCTGATCT TGCAGAAGAA 
AGAGGACTCA AAATTACTTA CAAATACACT GGAAAAGGGA TTACAGAGCC ACCTTTTGGT 
ATATTTGTCT TTAACAAAGA TACTGGAGAA CTGAATGTTA CCAGCATTCT TGATCGAGAA 
GAAACACCAT TTTTTCTGCT AACAGGTTAC GCTTTGGATG CAAGAGGAAA CAATGTAGAG 
AAACCCTTAG AGCTACGCAT TAAGGTTCTT GATATCAATG ACAACGAACC AGTGTTCACA 
CAGGATGTCT TTGTTGGGTC TGTTGAAGAG TTGAGTGCAG CACATACTCT TGTGATGAAA 
ATCAATGCAA CAGATGCAGA TGAGCCCAAT ACCCTGAATT CGAAAATTTC CTATAGAATC 
GTATCTCTGG AGCCTGCTTA TCCTCCAGTG TTCTACCTAA ATAAAGATAC AGGAGAGATT 
TATACAACCA GTGTTACCTT GGACAGAGAG GAACACAGCA GCTACACTTT GACAGTAGAA 
GCAAGAGATG GCAATGGAGA AGTTACAGAC AAACCTGTAA AACAAGCTCA AGTTCAGATT 
CGTATTTTGG ATGTCAATGA CAATATACCT GTAGTAGAAA ATAAAGTGCT TGAAGGGATG 
GTTGAAGAAA ATCAAGTCAA CGTAGAAGTT ACGCGCATAA AAGTGTTCGA TGCAGATGAA 
ATAGGTTCTG ATAATTGGCT GGCAAATTTT ACATTTGCAT CAGGAAATGA AGGAGGTTAT 
TTCCACATAG AAACAGATGC TCAAACTAAC GAAGGAATTG TGACCCTTAT TAAGGAAGTA 
GATTATGAAG AAATGAAGAA TCTTGACTTC AGTGTTATTG TCGCTAATAA AGCAGCTTTT 
CACAAGTCGA TTAGGAGTAA ATACAAGCCT ACACCCATTC CCATCAAGGT CAAAGTGAAA 
AATGTGAAAG AAGGCATTCA TTTTAAAAGC AGCGTCATCT CAATTTATGT TAGCGAGAGC 
ATGGATAGAT CAAGCAAAGG CCAAATAATT GGAAATTTTC AAGCTTTTGA TGAGGACACT 
GGACTACCAG CCCATGCAAG ATATGTAAAA TTAGAAGATA GAGATAATTG GATCTCTGTG 
GATTCTGTCA CATCTGAAAT TAAACTTGCA AAACTTCCTG ATTTTGAATC TAGATATGTT 
CAAAATGGCA CATACACTGT AAAGATTGTG GCCATATCAG AAGATTATCC TAGAAAAACC 
ATCACTGGCA CAGTCCTTAT CAATGTTGAA GACATCAACG ACAACTGTCC CACACTGATA 
GAGCCTGTGC AGACAATCTG TCACGATGCA GAGTATGTGA ATGTTACTGC AGAGGACCTG 
GATGGACACC CAAACAGTGG CCCTTTCAGT TTCTCCGTCA TTGACAAACC ACCTGGCATG 
GCAGAAAAAT GGAAAATAGC ACGCCAAGAA AGTACCAGTG TGCTGCTGCA ACAAAGTGAG 
AAAAAGCTTG GGAGAAGTGA AATTCAGTTC CTGATTTCAG ACAATCAGGG TTTTAGTTGT 
CCTGAAAAGC AGGTCCTTAC ACTCACAGTT TGTGAGTGTC TGCATGGCAG CGGCTGCAGG 
GAAGCACAGC ATGACTCCTA TGTGGGCCTG GGACCCGCAG CAATTGCGCT CATGATTTTG 
GCCTTTCTGC TCCTGCTATT GGTACCACTT TTACTGCTGA TGTGCCATTG CGGAAAGGGC 
GCCAAAGGCT TTACCCCCAT ACCTGGCACC ATAGAGATGC TGCATCCTTG GAATAATGAA 
GGAGCACCAC CTGAAGACAA GGTGGTGCCA TCATTTCTGC CAGTGGATCA AGGGGGCAGT 
CTAGTAGGAA GAAATGGAGT AGGAGGTATG GCCAAGGAAG CCACGATGAA AGGAAGTAGC 
TCTGCTTCCA TTGTCAAAGG GCAACATGAG ATGTCCGAGA TGGATGGAAG GTGGGAAGAA 
CACAGAAGCC TGCTTTCTGG TAGAGCTACC CAGTTTACAG GGGCCACAGG CGCTATCATG 
ACCACTGAAA CCACGAAGAC CGCAAGGGCC ACAGGGGCTT CCAGAGACAT GGCCGGAGCT 
CAGGCAGCTG CTGTTGCACT GAACGAAGAA TTCTTAAGAA ATTATTTCAC TGATAAAGCG 
GCCTCTTACA CTGAGGAAGA TGAAAATCAC ACAGCCAAAG ATTGCCTTCT GGTTTATTCT 
CAGGAAGAAA CTGAATCGCT GAATGCTTCT ATTGGTTGTT GCAGTTTTAT TGAAGGAGAG 
CTAGATGACC GCTTCTTAGA TGATTTGGGA CTTAAATTCA AGACACTAGC TGAAGTTTGC 
CTGGGTCAAA AAATAGATAT AAATAAGGAA ATTGAGCAGA GACAAAAACC TGCCACAGAA 
ACAAGTATGA ACACAGCTTC ACATTCACTC TGTGAGCAAA CTATGGTTAA TTCAGAGAAT 
ACCTACTCCT CTGGCAGTAG CTTCCCAGTT CCAAAATCTT TGCAAGAAGC CAATGCAGAG 
AAAGTAACTC AGGAAATAGT CACTGAAAGA TCTGTGTCTT CTAGGCAGGC GCAAAAGGTA 
GCTACACCTC TTCCTGACCC AATGGCTTCT AGAAATGTGA TAGCAACAGA AACTTCCTAT 
GTCACAGGGT CCACTATGCC ACCAACCACT GTGATCCTGG GTCCTAGCCA GCCACAGAGC 
CTTATTGTGA CAGAGAGGGT GTATGCTCCA GCTTCTACCT TGGTAGATCA GCCTTATGCT 
AATGAAGGTA CAGTTGTGGT CACTGAAAGA GTAATACAGC CTCATGGGGG TGGATCGAAT 
CCTCTGGAAG GCACTCAGCA TCTTCAAGAT GTACCTTACG TCATGGTGAG GGAAAGAGAG 
AGCTTCCTTG CCCCCAGCTC AGGTGTGCAG CCTACTCTGG CCATGCCTAA TATAGCAGTA 
GGACAGAATG TGACAGTGAC AGAAAGAGTT CTAGCACCTG CTTCCACTCT GCAATCCAGT 
TACCAGATTC CCACTGAAAA TTCTATGACG GCTAGGAACA CCACGGTGTC TGGAGCTGGA 
GTCCCTGGCC CTCTGCCAGA TTTTGGTTTA GAGGAATCTG GTCATTCTAA TTCTACCATA 
ACCACATCTT CCACCAGAGT TACCAAGCAT AGCACTGTAC AGCATTCTTA CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_001934.2

Translation

MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS

Target ORF information:

RefSeq Version	NM_001943.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens desmoglein 2 (DSG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001943.3

ORF Insert Sequence:

ATGGCGCGGA GCCCGGGACG CGCGTACGCC CTGCTGCTTC TCCTGATCTG CTTTAACGTT 
GGAAGTGGAC TTCACTTACA GGTCTTAAGC ACAAGAAATG AAAATAAGCT GCTTCCTAAA 
CATCCTCATT TAGTGCGGCA AAAGCGCGCC TGGATCACCG CCCCCGTGGC TCTTCGGGAG 
GGAGAGGATC TGTCCAAGAA GAATCCAATT GCCAAGATAC ATTCTGATCT TGCAGAAGAA 
AGAGGACTCA AAATTACTTA CAAATACACT GGAAAAGGGA TTACAGAGCC ACCTTTTGGT 
ATATTTGTCT TTAACAAAGA TACTGGAGAA CTGAATGTTA CCAGCATTCT TGATCGAGAA 
GAAACACCAT TTTTTCTGCT AACAGGTTAC GCTTTGGATG CAAGAGGAAA CAATGTAGAG 
AAACCCTTAG AGCTACGCAT TAAGGTTCTT GATATCAATG ACAACGAACC AGTGTTCACA 
CAGGATGTCT TTGTTGGGTC TGTTGAAGAG TTGAGTGCAG CACATACTCT TGTGATGAAA 
ATCAATGCAA CAGATGCAGA TGAGCCCAAT ACCCTGAATT CGAAAATTTC CTATAGAATC 
GTATCTCTGG AGCCTGCTTA TCCTCCAGTG TTCTACCTAA ATAAAGATAC AGGAGAGATT 
TATACAACCA GTGTTACCTT GGACAGAGAG GAACACAGCA GCTACACTTT GACAGTAGAA 
GCAAGAGATG GCAATGGAGA AGTTACAGAC AAACCTGTAA AACAAGCTCA AGTTCAGATT 
CGTATTTTGG ATGTCAATGA CAATATACCT GTAGTAGAAA ATAAAGTGCT TGAAGGGATG 
GTTGAAGAAA ATCAAGTCAA CGTAGAAGTT ACGCGCATAA AAGTGTTCGA TGCAGATGAA 
ATAGGTTCTG ATAATTGGCT GGCAAATTTT ACATTTGCAT CAGGAAATGA AGGAGGTTAT 
TTCCACATAG AAACAGATGC TCAAACTAAC GAAGGAATTG TGACCCTTAT TAAGGAAGTA 
GATTATGAAG AAATGAAGAA TCTTGACTTC AGTGTTATTG TCGCTAATAA AGCAGCTTTT 
CACAAGTCGA TTAGGAGTAA ATACAAGCCT ACACCCATTC CCATCAAGGT CAAAGTGAAA 
AATGTGAAAG AAGGCATTCA TTTTAAAAGC AGCGTCATCT CAATTTATGT TAGCGAGAGC 
ATGGATAGAT CAAGCAAAGG CCAAATAATT GGAAATTTTC AAGCTTTTGA TGAGGACACT 
GGACTACCAG CCCATGCAAG ATATGTAAAA TTAGAAGATA GAGATAATTG GATCTCTGTG 
GATTCTGTCA CATCTGAAAT TAAACTTGCA AAACTTCCTG ATTTTGAATC TAGATATGTT 
CAAAATGGCA CATACACTGT AAAGATTGTG GCCATATCAG AAGATTATCC TAGAAAAACC 
ATCACTGGCA CAGTCCTTAT CAATGTTGAA GACATCAACG ACAACTGTCC CACACTGATA 
GAGCCTGTGC AGACAATCTG TCACGATGCA GAGTATGTGA ATGTTACTGC AGAGGACCTG 
GATGGACACC CAAACAGTGG CCCTTTCAGT TTCTCCGTCA TTGACAAACC ACCTGGCATG 
GCAGAAAAAT GGAAAATAGC ACGCCAAGAA AGTACCAGTG TGCTGCTGCA ACAAAGTGAG 
AAAAAGCTTG GGAGAAGTGA AATTCAGTTC CTGATTTCAG ACAATCAGGG TTTTAGTTGT 
CCTGAAAAGC AGGTCCTTAC ACTCACAGTT TGTGAGTGTC TGCATGGCAG CGGCTGCAGG 
GAAGCACAGC ATGACTCCTA TGTGGGCCTG GGACCCGCAG CAATTGCGCT CATGATTTTG 
GCCTTTCTGC TCCTGCTATT GGTACCACTT TTACTGCTGA TGTGCCATTG CGGAAAGGGC 
GCCAAAGGCT TTACCCCCAT ACCTGGCACC ATAGAGATGC TGCATCCTTG GAATAATGAA 
GGAGCACCAC CTGAAGACAA GGTGGTGCCA TCATTTCTGC CAGTGGATCA AGGGGGCAGT 
CTAGTAGGAA GAAATGGAGT AGGAGGTATG GCCAAGGAAG CCACGATGAA AGGAAGTAGC 
TCTGCTTCCA TTGTCAAAGG GCAACATGAG ATGTCCGAGA TGGATGGAAG GTGGGAAGAA 
CACAGAAGCC TGCTTTCTGG TAGAGCTACC CAGTTTACAG GGGCCACAGG CGCTATCATG 
ACCACTGAAA CCACGAAGAC CGCAAGGGCC ACAGGGGCTT CCAGAGACAT GGCCGGAGCT 
CAGGCAGCTG CTGTTGCACT GAACGAAGAA TTCTTAAGAA ATTATTTCAC TGATAAAGCG 
GCCTCTTACA CTGAGGAAGA TGAAAATCAC ACAGCCAAAG ATTGCCTTCT GGTTTATTCT 
CAGGAAGAAA CTGAATCGCT GAATGCTTCT ATTGGTTGTT GCAGTTTTAT TGAAGGAGAG 
CTAGATGACC GCTTCTTAGA TGATTTGGGA CTTAAATTCA AGACACTAGC TGAAGTTTGC 
CTGGGTCAAA AAATAGATAT AAATAAGGAA ATTGAGCAGA GACAAAAACC TGCCACAGAA 
ACAAGTATGA ACACAGCTTC ACATTCACTC TGTGAGCAAA CTATGGTTAA TTCAGAGAAT 
ACCTACTCCT CTGGCAGTAG CTTCCCAGTT CCAAAATCTT TGCAAGAAGC CAATGCAGAG 
AAAGTAACTC AGGAAATAGT CACTGAAAGA TCTGTGTCTT CTAGGCAGGC GCAAAAGGTA 
GCTACACCTC TTCCTGACCC AATGGCTTCT AGAAATGTGA TAGCAACAGA AACTTCCTAT 
GTCACAGGGT CCACTATGCC ACCAACCACT GTGATCCTGG GTCCTAGCCA GCCACAGAGC 
CTTATTGTGA CAGAGAGGGT GTATGCTCCA GCTTCTACCT TGGTAGATCA GCCTTATGCT 
AATGAAGGTA CAGTTGTGGT CACTGAAAGA GTAATACAGC CTCATGGGGG TGGATCGAAT 
CCTCTGGAAG GCACTCAGCA TCTTCAAGAT GTACCTTACG TCATGGTGAG GGAAAGAGAG 
AGCTTCCTTG CCCCCAGCTC AGGTGTGCAG CCTACTCTGG CCATGCCTAA TATAGCAGTA 
GGACAGAATG TGACAGTGAC AGAAAGAGTT CTAGCACCTG CTTCCACTCT GCAATCCAGT 
TACCAGATTC CCACTGAAAA TTCTATGACG GCTAGGAACA CCACGGTGTC TGGAGCTGGA 
GTCCCTGGCC CTCTGCCAGA TTTTGGTTTA GAGGAATCTG GTCATTCTAA TTCTACCATA 
ACCACATCTT CCACCAGAGT TACCAAGCAT AGCACTGTAC AGCATTCTTA CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSG2 ( NM_001943.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001934.2 Homo sapiens desmoglein 2 (DSG2), mRNA.

Price & Availability↑

CloneID	OHu22755
Clone ID Related Accession (Same CDS sequence)	NM_001943.3 , NM_001943.4 , NM_001943.5
Accession Version	NM_001943.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1508688000000
Organism	Homo sapiens(human)
Product	desmoglein-2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY268349.1, DC417739.1, BC099657.3, CN395083.1, BC022413.1, DR158777.1, BC014581.1 and BQ023247.1. On Jan 8, 2016 this sequence version replaced NM_001943.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK308408.1, Z26317.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCGGA GCCCGGGACG CGCGTACGCC CTGCTGCTTC TCCTGATCTG CTTTAACGTT 
GGAAGTGGAC TTCACTTACA GGTCTTAAGC ACAAGAAATG AAAATAAGCT GCTTCCTAAA 
CATCCTCATT TAGTGCGGCA AAAGCGCGCC TGGATCACCG CCCCCGTGGC TCTTCGGGAG 
GGAGAGGATC TGTCCAAGAA GAATCCAATT GCCAAGATAC ATTCTGATCT TGCAGAAGAA 
AGAGGACTCA AAATTACTTA CAAATACACT GGAAAAGGGA TTACAGAGCC ACCTTTTGGT 
ATATTTGTCT TTAACAAAGA TACTGGAGAA CTGAATGTTA CCAGCATTCT TGATCGAGAA 
GAAACACCAT TTTTTCTGCT AACAGGTTAC GCTTTGGATG CAAGAGGAAA CAATGTAGAG 
AAACCCTTAG AGCTACGCAT TAAGGTTCTT GATATCAATG ACAACGAACC AGTGTTCACA 
CAGGATGTCT TTGTTGGGTC TGTTGAAGAG TTGAGTGCAG CACATACTCT TGTGATGAAA 
ATCAATGCAA CAGATGCAGA TGAGCCCAAT ACCCTGAATT CGAAAATTTC CTATAGAATC 
GTATCTCTGG AGCCTGCTTA TCCTCCAGTG TTCTACCTAA ATAAAGATAC AGGAGAGATT 
TATACAACCA GTGTTACCTT GGACAGAGAG GAACACAGCA GCTACACTTT GACAGTAGAA 
GCAAGAGATG GCAATGGAGA AGTTACAGAC AAACCTGTAA AACAAGCTCA AGTTCAGATT 
CGTATTTTGG ATGTCAATGA CAATATACCT GTAGTAGAAA ATAAAGTGCT TGAAGGGATG 
GTTGAAGAAA ATCAAGTCAA CGTAGAAGTT ACGCGCATAA AAGTGTTCGA TGCAGATGAA 
ATAGGTTCTG ATAATTGGCT GGCAAATTTT ACATTTGCAT CAGGAAATGA AGGAGGTTAT 
TTCCACATAG AAACAGATGC TCAAACTAAC GAAGGAATTG TGACCCTTAT TAAGGAAGTA 
GATTATGAAG AAATGAAGAA TCTTGACTTC AGTGTTATTG TCGCTAATAA AGCAGCTTTT 
CACAAGTCGA TTAGGAGTAA ATACAAGCCT ACACCCATTC CCATCAAGGT CAAAGTGAAA 
AATGTGAAAG AAGGCATTCA TTTTAAAAGC AGCGTCATCT CAATTTATGT TAGCGAGAGC 
ATGGATAGAT CAAGCAAAGG CCAAATAATT GGAAATTTTC AAGCTTTTGA TGAGGACACT 
GGACTACCAG CCCATGCAAG ATATGTAAAA TTAGAAGATA GAGATAATTG GATCTCTGTG 
GATTCTGTCA CATCTGAAAT TAAACTTGCA AAACTTCCTG ATTTTGAATC TAGATATGTT 
CAAAATGGCA CATACACTGT AAAGATTGTG GCCATATCAG AAGATTATCC TAGAAAAACC 
ATCACTGGCA CAGTCCTTAT CAATGTTGAA GACATCAACG ACAACTGTCC CACACTGATA 
GAGCCTGTGC AGACAATCTG TCACGATGCA GAGTATGTGA ATGTTACTGC AGAGGACCTG 
GATGGACACC CAAACAGTGG CCCTTTCAGT TTCTCCGTCA TTGACAAACC ACCTGGCATG 
GCAGAAAAAT GGAAAATAGC ACGCCAAGAA AGTACCAGTG TGCTGCTGCA ACAAAGTGAG 
AAAAAGCTTG GGAGAAGTGA AATTCAGTTC CTGATTTCAG ACAATCAGGG TTTTAGTTGT 
CCTGAAAAGC AGGTCCTTAC ACTCACAGTT TGTGAGTGTC TGCATGGCAG CGGCTGCAGG 
GAAGCACAGC ATGACTCCTA TGTGGGCCTG GGACCCGCAG CAATTGCGCT CATGATTTTG 
GCCTTTCTGC TCCTGCTATT GGTACCACTT TTACTGCTGA TGTGCCATTG CGGAAAGGGC 
GCCAAAGGCT TTACCCCCAT ACCTGGCACC ATAGAGATGC TGCATCCTTG GAATAATGAA 
GGAGCACCAC CTGAAGACAA GGTGGTGCCA TCATTTCTGC CAGTGGATCA AGGGGGCAGT 
CTAGTAGGAA GAAATGGAGT AGGAGGTATG GCCAAGGAAG CCACGATGAA AGGAAGTAGC 
TCTGCTTCCA TTGTCAAAGG GCAACATGAG ATGTCCGAGA TGGATGGAAG GTGGGAAGAA 
CACAGAAGCC TGCTTTCTGG TAGAGCTACC CAGTTTACAG GGGCCACAGG CGCTATCATG 
ACCACTGAAA CCACGAAGAC CGCAAGGGCC ACAGGGGCTT CCAGAGACAT GGCCGGAGCT 
CAGGCAGCTG CTGTTGCACT GAACGAAGAA TTCTTAAGAA ATTATTTCAC TGATAAAGCG 
GCCTCTTACA CTGAGGAAGA TGAAAATCAC ACAGCCAAAG ATTGCCTTCT GGTTTATTCT 
CAGGAAGAAA CTGAATCGCT GAATGCTTCT ATTGGTTGTT GCAGTTTTAT TGAAGGAGAG 
CTAGATGACC GCTTCTTAGA TGATTTGGGA CTTAAATTCA AGACACTAGC TGAAGTTTGC 
CTGGGTCAAA AAATAGATAT AAATAAGGAA ATTGAGCAGA GACAAAAACC TGCCACAGAA 
ACAAGTATGA ACACAGCTTC ACATTCACTC TGTGAGCAAA CTATGGTTAA TTCAGAGAAT 
ACCTACTCCT CTGGCAGTAG CTTCCCAGTT CCAAAATCTT TGCAAGAAGC CAATGCAGAG 
AAAGTAACTC AGGAAATAGT CACTGAAAGA TCTGTGTCTT CTAGGCAGGC GCAAAAGGTA 
GCTACACCTC TTCCTGACCC AATGGCTTCT AGAAATGTGA TAGCAACAGA AACTTCCTAT 
GTCACAGGGT CCACTATGCC ACCAACCACT GTGATCCTGG GTCCTAGCCA GCCACAGAGC 
CTTATTGTGA CAGAGAGGGT GTATGCTCCA GCTTCTACCT TGGTAGATCA GCCTTATGCT 
AATGAAGGTA CAGTTGTGGT CACTGAAAGA GTAATACAGC CTCATGGGGG TGGATCGAAT 
CCTCTGGAAG GCACTCAGCA TCTTCAAGAT GTACCTTACG TCATGGTGAG GGAAAGAGAG 
AGCTTCCTTG CCCCCAGCTC AGGTGTGCAG CCTACTCTGG CCATGCCTAA TATAGCAGTA 
GGACAGAATG TGACAGTGAC AGAAAGAGTT CTAGCACCTG CTTCCACTCT GCAATCCAGT 
TACCAGATTC CCACTGAAAA TTCTATGACG GCTAGGAACA CCACGGTGTC TGGAGCTGGA 
GTCCCTGGCC CTCTGCCAGA TTTTGGTTTA GAGGAATCTG GTCATTCTAA TTCTACCATA 
ACCACATCTT CCACCAGAGT TACCAAGCAT AGCACTGTAC AGCATTCTTA CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001934.2
CDS	249..3605
Translation	MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS

Target ORF information:

RefSeq Version	NM_001943.4
Organism	Homo sapiens(human)
Definition	Homo sapiens desmoglein 2 (DSG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001943.4

ORF Insert Sequence:

ATGGCGCGGA GCCCGGGACG CGCGTACGCC CTGCTGCTTC TCCTGATCTG CTTTAACGTT 
GGAAGTGGAC TTCACTTACA GGTCTTAAGC ACAAGAAATG AAAATAAGCT GCTTCCTAAA 
CATCCTCATT TAGTGCGGCA AAAGCGCGCC TGGATCACCG CCCCCGTGGC TCTTCGGGAG 
GGAGAGGATC TGTCCAAGAA GAATCCAATT GCCAAGATAC ATTCTGATCT TGCAGAAGAA 
AGAGGACTCA AAATTACTTA CAAATACACT GGAAAAGGGA TTACAGAGCC ACCTTTTGGT 
ATATTTGTCT TTAACAAAGA TACTGGAGAA CTGAATGTTA CCAGCATTCT TGATCGAGAA 
GAAACACCAT TTTTTCTGCT AACAGGTTAC GCTTTGGATG CAAGAGGAAA CAATGTAGAG 
AAACCCTTAG AGCTACGCAT TAAGGTTCTT GATATCAATG ACAACGAACC AGTGTTCACA 
CAGGATGTCT TTGTTGGGTC TGTTGAAGAG TTGAGTGCAG CACATACTCT TGTGATGAAA 
ATCAATGCAA CAGATGCAGA TGAGCCCAAT ACCCTGAATT CGAAAATTTC CTATAGAATC 
GTATCTCTGG AGCCTGCTTA TCCTCCAGTG TTCTACCTAA ATAAAGATAC AGGAGAGATT 
TATACAACCA GTGTTACCTT GGACAGAGAG GAACACAGCA GCTACACTTT GACAGTAGAA 
GCAAGAGATG GCAATGGAGA AGTTACAGAC AAACCTGTAA AACAAGCTCA AGTTCAGATT 
CGTATTTTGG ATGTCAATGA CAATATACCT GTAGTAGAAA ATAAAGTGCT TGAAGGGATG 
GTTGAAGAAA ATCAAGTCAA CGTAGAAGTT ACGCGCATAA AAGTGTTCGA TGCAGATGAA 
ATAGGTTCTG ATAATTGGCT GGCAAATTTT ACATTTGCAT CAGGAAATGA AGGAGGTTAT 
TTCCACATAG AAACAGATGC TCAAACTAAC GAAGGAATTG TGACCCTTAT TAAGGAAGTA 
GATTATGAAG AAATGAAGAA TCTTGACTTC AGTGTTATTG TCGCTAATAA AGCAGCTTTT 
CACAAGTCGA TTAGGAGTAA ATACAAGCCT ACACCCATTC CCATCAAGGT CAAAGTGAAA 
AATGTGAAAG AAGGCATTCA TTTTAAAAGC AGCGTCATCT CAATTTATGT TAGCGAGAGC 
ATGGATAGAT CAAGCAAAGG CCAAATAATT GGAAATTTTC AAGCTTTTGA TGAGGACACT 
GGACTACCAG CCCATGCAAG ATATGTAAAA TTAGAAGATA GAGATAATTG GATCTCTGTG 
GATTCTGTCA CATCTGAAAT TAAACTTGCA AAACTTCCTG ATTTTGAATC TAGATATGTT 
CAAAATGGCA CATACACTGT AAAGATTGTG GCCATATCAG AAGATTATCC TAGAAAAACC 
ATCACTGGCA CAGTCCTTAT CAATGTTGAA GACATCAACG ACAACTGTCC CACACTGATA 
GAGCCTGTGC AGACAATCTG TCACGATGCA GAGTATGTGA ATGTTACTGC AGAGGACCTG 
GATGGACACC CAAACAGTGG CCCTTTCAGT TTCTCCGTCA TTGACAAACC ACCTGGCATG 
GCAGAAAAAT GGAAAATAGC ACGCCAAGAA AGTACCAGTG TGCTGCTGCA ACAAAGTGAG 
AAAAAGCTTG GGAGAAGTGA AATTCAGTTC CTGATTTCAG ACAATCAGGG TTTTAGTTGT 
CCTGAAAAGC AGGTCCTTAC ACTCACAGTT TGTGAGTGTC TGCATGGCAG CGGCTGCAGG 
GAAGCACAGC ATGACTCCTA TGTGGGCCTG GGACCCGCAG CAATTGCGCT CATGATTTTG 
GCCTTTCTGC TCCTGCTATT GGTACCACTT TTACTGCTGA TGTGCCATTG CGGAAAGGGC 
GCCAAAGGCT TTACCCCCAT ACCTGGCACC ATAGAGATGC TGCATCCTTG GAATAATGAA 
GGAGCACCAC CTGAAGACAA GGTGGTGCCA TCATTTCTGC CAGTGGATCA AGGGGGCAGT 
CTAGTAGGAA GAAATGGAGT AGGAGGTATG GCCAAGGAAG CCACGATGAA AGGAAGTAGC 
TCTGCTTCCA TTGTCAAAGG GCAACATGAG ATGTCCGAGA TGGATGGAAG GTGGGAAGAA 
CACAGAAGCC TGCTTTCTGG TAGAGCTACC CAGTTTACAG GGGCCACAGG CGCTATCATG 
ACCACTGAAA CCACGAAGAC CGCAAGGGCC ACAGGGGCTT CCAGAGACAT GGCCGGAGCT 
CAGGCAGCTG CTGTTGCACT GAACGAAGAA TTCTTAAGAA ATTATTTCAC TGATAAAGCG 
GCCTCTTACA CTGAGGAAGA TGAAAATCAC ACAGCCAAAG ATTGCCTTCT GGTTTATTCT 
CAGGAAGAAA CTGAATCGCT GAATGCTTCT ATTGGTTGTT GCAGTTTTAT TGAAGGAGAG 
CTAGATGACC GCTTCTTAGA TGATTTGGGA CTTAAATTCA AGACACTAGC TGAAGTTTGC 
CTGGGTCAAA AAATAGATAT AAATAAGGAA ATTGAGCAGA GACAAAAACC TGCCACAGAA 
ACAAGTATGA ACACAGCTTC ACATTCACTC TGTGAGCAAA CTATGGTTAA TTCAGAGAAT 
ACCTACTCCT CTGGCAGTAG CTTCCCAGTT CCAAAATCTT TGCAAGAAGC CAATGCAGAG 
AAAGTAACTC AGGAAATAGT CACTGAAAGA TCTGTGTCTT CTAGGCAGGC GCAAAAGGTA 
GCTACACCTC TTCCTGACCC AATGGCTTCT AGAAATGTGA TAGCAACAGA AACTTCCTAT 
GTCACAGGGT CCACTATGCC ACCAACCACT GTGATCCTGG GTCCTAGCCA GCCACAGAGC 
CTTATTGTGA CAGAGAGGGT GTATGCTCCA GCTTCTACCT TGGTAGATCA GCCTTATGCT 
AATGAAGGTA CAGTTGTGGT CACTGAAAGA GTAATACAGC CTCATGGGGG TGGATCGAAT 
CCTCTGGAAG GCACTCAGCA TCTTCAAGAT GTACCTTACG TCATGGTGAG GGAAAGAGAG 
AGCTTCCTTG CCCCCAGCTC AGGTGTGCAG CCTACTCTGG CCATGCCTAA TATAGCAGTA 
GGACAGAATG TGACAGTGAC AGAAAGAGTT CTAGCACCTG CTTCCACTCT GCAATCCAGT 
TACCAGATTC CCACTGAAAA TTCTATGACG GCTAGGAACA CCACGGTGTC TGGAGCTGGA 
GTCCCTGGCC CTCTGCCAGA TTTTGGTTTA GAGGAATCTG GTCATTCTAA TTCTACCATA 
ACCACATCTT CCACCAGAGT TACCAAGCAT AGCACTGTAC AGCATTCTTA CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSG2 ( XM_024451095.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024306863.1 Homo sapiens desmoglein 2 (DSG2), transcript variant X1, mRNA.

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CloneID	OHu104508
Clone ID Related Accession (Same CDS sequence)	XM_024451095.1
Accession Version	XM_024451095.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2823bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	desmoglein-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAAATCA ATGCAACAGA TGCAGATGAG CCCAATACCC TGAATTCGAA AATTTCCTAT 
AGAATCGTAT CTCTGGAGCC TGCTTATCCT CCAGTGTTCT ACCTAAATAA AGATACAGGA 
GAGATTTATA CAACCAGTGT TACCTTGGAC AGAGAGGAAC ACAGCAGCTA CACTTTGACA 
GTAGAAGCAA GAGATGGCAA TGGAGAAGTT ACAGACAAAC CTGTAAAACA AGCTCAAGTT 
CAGATTCGTA TTTTGGATGT CAATGACAAT ATACCTGTAG TAGAAAATAA AGTGCTTGAA 
GGGATGGTTG AAGAAAATCA AGTCAACGTA GAAGTTACGC GCATAAAAGT GTTCGATGCA 
GATGAAATAG GTTCTGATAA TTGGCTGGCA AATTTTACAT TTGCATCAGG AAATGAAGGA 
GGTTATTTCC ACATAGAAAC AGATGCTCAA ACTAACGAAG GAATTGTGAC CCTTATTAAG 
GAAGTAGATT ATGAAGAAAT GAAGAATCTT GACTTCAGTG TTATTGTCGC TAATAAAGCA 
GCTTTTCACA AGTCGATTAG GAGTAAATAC AAGCCTACAC CCATTCCCAT CAAGGTCAAA 
GTGAAAAATG TGAAAGAAGG CATTCATTTT AAAAGCAGCG TCATCTCAAT TTATGTTAGC 
GAGAGCATGG ATAGATCAAG CAAAGGCCAA ATAATTGGAA ATTTTCAAGC TTTTGATGAG 
GACACTGGAC TACCAGCCCA TGCAAGATAT GTAAAATTAG AAGATAGAGA TAATTGGATC 
TCTGTGGATT CTGTCACATC TGAAATTAAA CTTGCAAAAC TTCCTGATTT TGAATCTAGA 
TATGTTCAAA ATGGCACATA CACTGTAAAG ATTGTGGCCA TATCAGAAGA TTATCCTAGA 
AAAACCATCA CTGGCACAGT CCTTATCAAT GTTGAAGACA TCAACGACAA CTGTCCCACA 
CTGATAGAGC CTGTGCAGAC AATCTGTCAC GATGCAGAGT ATGTGAATGT TACTGCAGAG 
GACCTGGATG GACACCCAAA CAGTGGCCCT TTCAGTTTCT CCGTCATTGA CAAACCACCT 
GGCATGGCAG AAAAATGGAA AATAGCACGC CAAGAAAGTA CCAGTGTGCT GCTGCAACAA 
AGTGAGAAAA AGCTTGGGAG AAGTGAAATT CAGTTCCTGA TTTCAGACAA TCAGGGTTTT 
AGTTGTCCTG AAAAGCAGGT CCTTACACTC ACAGTTTGTG AGTGTCTGCA TGGCAGCGGC 
TGCAGGGAAG CACAGCATGA CTCCTATGTG GGCCTGGGAC CCGCAGCAAT TGCGCTCATG 
ATTTTGGCCT TTCTGCTCCT GCTATTGGTA CCACTTTTAC TGCTGATGTG CCATTGCGGA 
AAGGGCGCCA AAGGCTTTAC CCCCATACCT GGCACCATAG AGATGCTGCA TCCTTGGAAT 
AATGAAGGAG CACCACCTGA AGACAAGGTG GTGCCATCAT TTCTGCCAGT GGATCAAGGG 
GGCAGTCTAG TAGGAAGAAA TGGAGTAGGA GGTATGGCCA AGGAAGCCAC GATGAAAGGA 
AGTAGCTCTG CTTCCATTGT CAAAGGGCAA CATGAGATGT CCGAGATGGA TGGAAGGTGG 
GAAGAACACA GAAGCCTGCT TTCTGGTAGA GCTACCCAGT TTACAGGGGC CACAGGCGCT 
ATCATGACCA CTGAAACCAC GAAGACCGCA AGGGCCACAG GGGCTTCCAG AGACATGGCC 
GGAGCTCAGG CAGCTGCTGT TGCACTGAAC GAAGAATTCT TAAGAAATTA TTTCACTGAT 
AAAGCGGCCT CTTACACTGA GGAAGATGAA AATCACACAG CCAAAGATTG CCTTCTGGTT 
TATTCTCAGG AAGAAACTGA ATCGCTGAAT GCTTCTATTG GTTGTTGCAG TTTTATTGAA 
GGAGAGCTAG ATGACCGCTT CTTAGATGAT TTGGGACTTA AATTCAAGAC ACTAGCTGAA 
GTTTGCCTGG GTCAAAAAAT AGATATAAAT AAGGAAATTG AGCAGAGACA AAAACCTGCC 
ACAGAAACAA GTATGAACAC AGCTTCACAT TCACTCTGTG AGCAAACTAT GGTTAATTCA 
GAGAATACCT ACTCCTCTGG CAGTAGCTTC CCAGTTCCAA AATCTTTGCA AGAAGCCAAT 
GCAGAGAAAG TAACTCAGGA AATAGTCACT GAAAGATCTG TGTCTTCTAG GCAGGCGCAA 
AAGGTAGCTA CACCTCTTCC TGACCCAATG GCTTCTAGAA ATGTGATAGC AACAGAAACT 
TCCTATGTCA CAGGGTCCAC TATGCCACCA ACCACTGTGA TCCTGGGTCC TAGCCAGCCA 
CAGAGCCTTA TTGTGACAGA GAGGGTGTAT GCTCCAGCTT CTACCTTGGT AGATCAGCCT 
TATGCTAATG AAGGTACAGT TGTGGTCACT GAAAGAGTAA TACAGCCTCA TGGGGGTGGA 
TCGAATCCTC TGGAAGGCAC TCAGCATCTT CAAGATGTAC CTTACGTCAT GGTGAGGGAA 
AGAGAGAGCT TCCTTGCCCC CAGCTCAGGT GTGCAGCCTA CTCTGGCCAT GCCTAATATA 
GCAGTAGGAC AGAATGTGAC AGTGACAGAA AGAGTTCTAG CACCTGCTTC CACTCTGCAA 
TCCAGTTACC AGATTCCCAC TGAAAATTCT ATGACGGCTA GGAACACCAC GGTGTCTGGA 
GCTGGAGTCC CTGGCCCTCT GCCAGATTTT GGTTTAGAGG AATCTGGTCA TTCTAATTCT 
ACCATAACCA CATCTTCCAC CAGAGTTACC AAGCATAGCA CTGTACAGCA TTCTTACTCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024306863.1
CDS	509..3331
Translation	MKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS

Target ORF information:

RefSeq Version	XM_024451095.1
Organism	Homo sapiens(human)
Definition	Homo sapiens desmoglein 2 (DSG2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024451095.1

ORF Insert Sequence:

ATGAAAATCA ATGCAACAGA TGCAGATGAG CCCAATACCC TGAATTCGAA AATTTCCTAT 
AGAATCGTAT CTCTGGAGCC TGCTTATCCT CCAGTGTTCT ACCTAAATAA AGATACAGGA 
GAGATTTATA CAACCAGTGT TACCTTGGAC AGAGAGGAAC ACAGCAGCTA CACTTTGACA 
GTAGAAGCAA GAGATGGCAA TGGAGAAGTT ACAGACAAAC CTGTAAAACA AGCTCAAGTT 
CAGATTCGTA TTTTGGATGT CAATGACAAT ATACCTGTAG TAGAAAATAA AGTGCTTGAA 
GGGATGGTTG AAGAAAATCA AGTCAACGTA GAAGTTACGC GCATAAAAGT GTTCGATGCA 
GATGAAATAG GTTCTGATAA TTGGCTGGCA AATTTTACAT TTGCATCAGG AAATGAAGGA 
GGTTATTTCC ACATAGAAAC AGATGCTCAA ACTAACGAAG GAATTGTGAC CCTTATTAAG 
GAAGTAGATT ATGAAGAAAT GAAGAATCTT GACTTCAGTG TTATTGTCGC TAATAAAGCA 
GCTTTTCACA AGTCGATTAG GAGTAAATAC AAGCCTACAC CCATTCCCAT CAAGGTCAAA 
GTGAAAAATG TGAAAGAAGG CATTCATTTT AAAAGCAGCG TCATCTCAAT TTATGTTAGC 
GAGAGCATGG ATAGATCAAG CAAAGGCCAA ATAATTGGAA ATTTTCAAGC TTTTGATGAG 
GACACTGGAC TACCAGCCCA TGCAAGATAT GTAAAATTAG AAGATAGAGA TAATTGGATC 
TCTGTGGATT CTGTCACATC TGAAATTAAA CTTGCAAAAC TTCCTGATTT TGAATCTAGA 
TATGTTCAAA ATGGCACATA CACTGTAAAG ATTGTGGCCA TATCAGAAGA TTATCCTAGA 
AAAACCATCA CTGGCACAGT CCTTATCAAT GTTGAAGACA TCAACGACAA CTGTCCCACA 
CTGATAGAGC CTGTGCAGAC AATCTGTCAC GATGCAGAGT ATGTGAATGT TACTGCAGAG 
GACCTGGATG GACACCCAAA CAGTGGCCCT TTCAGTTTCT CCGTCATTGA CAAACCACCT 
GGCATGGCAG AAAAATGGAA AATAGCACGC CAAGAAAGTA CCAGTGTGCT GCTGCAACAA 
AGTGAGAAAA AGCTTGGGAG AAGTGAAATT CAGTTCCTGA TTTCAGACAA TCAGGGTTTT 
AGTTGTCCTG AAAAGCAGGT CCTTACACTC ACAGTTTGTG AGTGTCTGCA TGGCAGCGGC 
TGCAGGGAAG CACAGCATGA CTCCTATGTG GGCCTGGGAC CCGCAGCAAT TGCGCTCATG 
ATTTTGGCCT TTCTGCTCCT GCTATTGGTA CCACTTTTAC TGCTGATGTG CCATTGCGGA 
AAGGGCGCCA AAGGCTTTAC CCCCATACCT GGCACCATAG AGATGCTGCA TCCTTGGAAT 
AATGAAGGAG CACCACCTGA AGACAAGGTG GTGCCATCAT TTCTGCCAGT GGATCAAGGG 
GGCAGTCTAG TAGGAAGAAA TGGAGTAGGA GGTATGGCCA AGGAAGCCAC GATGAAAGGA 
AGTAGCTCTG CTTCCATTGT CAAAGGGCAA CATGAGATGT CCGAGATGGA TGGAAGGTGG 
GAAGAACACA GAAGCCTGCT TTCTGGTAGA GCTACCCAGT TTACAGGGGC CACAGGCGCT 
ATCATGACCA CTGAAACCAC GAAGACCGCA AGGGCCACAG GGGCTTCCAG AGACATGGCC 
GGAGCTCAGG CAGCTGCTGT TGCACTGAAC GAAGAATTCT TAAGAAATTA TTTCACTGAT 
AAAGCGGCCT CTTACACTGA GGAAGATGAA AATCACACAG CCAAAGATTG CCTTCTGGTT 
TATTCTCAGG AAGAAACTGA ATCGCTGAAT GCTTCTATTG GTTGTTGCAG TTTTATTGAA 
GGAGAGCTAG ATGACCGCTT CTTAGATGAT TTGGGACTTA AATTCAAGAC ACTAGCTGAA 
GTTTGCCTGG GTCAAAAAAT AGATATAAAT AAGGAAATTG AGCAGAGACA AAAACCTGCC 
ACAGAAACAA GTATGAACAC AGCTTCACAT TCACTCTGTG AGCAAACTAT GGTTAATTCA 
GAGAATACCT ACTCCTCTGG CAGTAGCTTC CCAGTTCCAA AATCTTTGCA AGAAGCCAAT 
GCAGAGAAAG TAACTCAGGA AATAGTCACT GAAAGATCTG TGTCTTCTAG GCAGGCGCAA 
AAGGTAGCTA CACCTCTTCC TGACCCAATG GCTTCTAGAA ATGTGATAGC AACAGAAACT 
TCCTATGTCA CAGGGTCCAC TATGCCACCA ACCACTGTGA TCCTGGGTCC TAGCCAGCCA 
CAGAGCCTTA TTGTGACAGA GAGGGTGTAT GCTCCAGCTT CTACCTTGGT AGATCAGCCT 
TATGCTAATG AAGGTACAGT TGTGGTCACT GAAAGAGTAA TACAGCCTCA TGGGGGTGGA 
TCGAATCCTC TGGAAGGCAC TCAGCATCTT CAAGATGTAC CTTACGTCAT GGTGAGGGAA 
AGAGAGAGCT TCCTTGCCCC CAGCTCAGGT GTGCAGCCTA CTCTGGCCAT GCCTAATATA 
GCAGTAGGAC AGAATGTGAC AGTGACAGAA AGAGTTCTAG CACCTGCTTC CACTCTGCAA 
TCCAGTTACC AGATTCCCAC TGAAAATTCT ATGACGGCTA GGAACACCAC GGTGTCTGGA 
GCTGGAGTCC CTGGCCCTCT GCCAGATTTT GGTTTAGAGG AATCTGGTCA TTCTAATTCT 
ACCATAACCA CATCTTCCAC CAGAGTTACC AAGCATAGCA CTGTACAGCA TTCTTACTCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSG2 ( NM_001943.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001934.2 Homo sapiens desmoglein 2 (DSG2), mRNA.

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CloneID	OHu22755
Clone ID Related Accession (Same CDS sequence)	NM_001943.3 , NM_001943.4 , NM_001943.5
Accession Version	NM_001943.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Homo sapiens(human)
Product	desmoglein-2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY268349.1, DC417739.1, BC099657.3, CN395083.1, BC022413.1, DR158777.1, BC014581.1 and BQ023247.1. On Nov 22, 2018 this sequence version replaced NM_001943.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK308408.1, Z26317.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261590.13/ ENSP00000261590.8 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCGGA GCCCGGGACG CGCGTACGCC CTGCTGCTTC TCCTGATCTG CTTTAACGTT 
GGAAGTGGAC TTCACTTACA GGTCTTAAGC ACAAGAAATG AAAATAAGCT GCTTCCTAAA 
CATCCTCATT TAGTGCGGCA AAAGCGCGCC TGGATCACCG CCCCCGTGGC TCTTCGGGAG 
GGAGAGGATC TGTCCAAGAA GAATCCAATT GCCAAGATAC ATTCTGATCT TGCAGAAGAA 
AGAGGACTCA AAATTACTTA CAAATACACT GGAAAAGGGA TTACAGAGCC ACCTTTTGGT 
ATATTTGTCT TTAACAAAGA TACTGGAGAA CTGAATGTTA CCAGCATTCT TGATCGAGAA 
GAAACACCAT TTTTTCTGCT AACAGGTTAC GCTTTGGATG CAAGAGGAAA CAATGTAGAG 
AAACCCTTAG AGCTACGCAT TAAGGTTCTT GATATCAATG ACAACGAACC AGTGTTCACA 
CAGGATGTCT TTGTTGGGTC TGTTGAAGAG TTGAGTGCAG CACATACTCT TGTGATGAAA 
ATCAATGCAA CAGATGCAGA TGAGCCCAAT ACCCTGAATT CGAAAATTTC CTATAGAATC 
GTATCTCTGG AGCCTGCTTA TCCTCCAGTG TTCTACCTAA ATAAAGATAC AGGAGAGATT 
TATACAACCA GTGTTACCTT GGACAGAGAG GAACACAGCA GCTACACTTT GACAGTAGAA 
GCAAGAGATG GCAATGGAGA AGTTACAGAC AAACCTGTAA AACAAGCTCA AGTTCAGATT 
CGTATTTTGG ATGTCAATGA CAATATACCT GTAGTAGAAA ATAAAGTGCT TGAAGGGATG 
GTTGAAGAAA ATCAAGTCAA CGTAGAAGTT ACGCGCATAA AAGTGTTCGA TGCAGATGAA 
ATAGGTTCTG ATAATTGGCT GGCAAATTTT ACATTTGCAT CAGGAAATGA AGGAGGTTAT 
TTCCACATAG AAACAGATGC TCAAACTAAC GAAGGAATTG TGACCCTTAT TAAGGAAGTA 
GATTATGAAG AAATGAAGAA TCTTGACTTC AGTGTTATTG TCGCTAATAA AGCAGCTTTT 
CACAAGTCGA TTAGGAGTAA ATACAAGCCT ACACCCATTC CCATCAAGGT CAAAGTGAAA 
AATGTGAAAG AAGGCATTCA TTTTAAAAGC AGCGTCATCT CAATTTATGT TAGCGAGAGC 
ATGGATAGAT CAAGCAAAGG CCAAATAATT GGAAATTTTC AAGCTTTTGA TGAGGACACT 
GGACTACCAG CCCATGCAAG ATATGTAAAA TTAGAAGATA GAGATAATTG GATCTCTGTG 
GATTCTGTCA CATCTGAAAT TAAACTTGCA AAACTTCCTG ATTTTGAATC TAGATATGTT 
CAAAATGGCA CATACACTGT AAAGATTGTG GCCATATCAG AAGATTATCC TAGAAAAACC 
ATCACTGGCA CAGTCCTTAT CAATGTTGAA GACATCAACG ACAACTGTCC CACACTGATA 
GAGCCTGTGC AGACAATCTG TCACGATGCA GAGTATGTGA ATGTTACTGC AGAGGACCTG 
GATGGACACC CAAACAGTGG CCCTTTCAGT TTCTCCGTCA TTGACAAACC ACCTGGCATG 
GCAGAAAAAT GGAAAATAGC ACGCCAAGAA AGTACCAGTG TGCTGCTGCA ACAAAGTGAG 
AAAAAGCTTG GGAGAAGTGA AATTCAGTTC CTGATTTCAG ACAATCAGGG TTTTAGTTGT 
CCTGAAAAGC AGGTCCTTAC ACTCACAGTT TGTGAGTGTC TGCATGGCAG CGGCTGCAGG 
GAAGCACAGC ATGACTCCTA TGTGGGCCTG GGACCCGCAG CAATTGCGCT CATGATTTTG 
GCCTTTCTGC TCCTGCTATT GGTACCACTT TTACTGCTGA TGTGCCATTG CGGAAAGGGC 
GCCAAAGGCT TTACCCCCAT ACCTGGCACC ATAGAGATGC TGCATCCTTG GAATAATGAA 
GGAGCACCAC CTGAAGACAA GGTGGTGCCA TCATTTCTGC CAGTGGATCA AGGGGGCAGT 
CTAGTAGGAA GAAATGGAGT AGGAGGTATG GCCAAGGAAG CCACGATGAA AGGAAGTAGC 
TCTGCTTCCA TTGTCAAAGG GCAACATGAG ATGTCCGAGA TGGATGGAAG GTGGGAAGAA 
CACAGAAGCC TGCTTTCTGG TAGAGCTACC CAGTTTACAG GGGCCACAGG CGCTATCATG 
ACCACTGAAA CCACGAAGAC CGCAAGGGCC ACAGGGGCTT CCAGAGACAT GGCCGGAGCT 
CAGGCAGCTG CTGTTGCACT GAACGAAGAA TTCTTAAGAA ATTATTTCAC TGATAAAGCG 
GCCTCTTACA CTGAGGAAGA TGAAAATCAC ACAGCCAAAG ATTGCCTTCT GGTTTATTCT 
CAGGAAGAAA CTGAATCGCT GAATGCTTCT ATTGGTTGTT GCAGTTTTAT TGAAGGAGAG 
CTAGATGACC GCTTCTTAGA TGATTTGGGA CTTAAATTCA AGACACTAGC TGAAGTTTGC 
CTGGGTCAAA AAATAGATAT AAATAAGGAA ATTGAGCAGA GACAAAAACC TGCCACAGAA 
ACAAGTATGA ACACAGCTTC ACATTCACTC TGTGAGCAAA CTATGGTTAA TTCAGAGAAT 
ACCTACTCCT CTGGCAGTAG CTTCCCAGTT CCAAAATCTT TGCAAGAAGC CAATGCAGAG 
AAAGTAACTC AGGAAATAGT CACTGAAAGA TCTGTGTCTT CTAGGCAGGC GCAAAAGGTA 
GCTACACCTC TTCCTGACCC AATGGCTTCT AGAAATGTGA TAGCAACAGA AACTTCCTAT 
GTCACAGGGT CCACTATGCC ACCAACCACT GTGATCCTGG GTCCTAGCCA GCCACAGAGC 
CTTATTGTGA CAGAGAGGGT GTATGCTCCA GCTTCTACCT TGGTAGATCA GCCTTATGCT 
AATGAAGGTA CAGTTGTGGT CACTGAAAGA GTAATACAGC CTCATGGGGG TGGATCGAAT 
CCTCTGGAAG GCACTCAGCA TCTTCAAGAT GTACCTTACG TCATGGTGAG GGAAAGAGAG 
AGCTTCCTTG CCCCCAGCTC AGGTGTGCAG CCTACTCTGG CCATGCCTAA TATAGCAGTA 
GGACAGAATG TGACAGTGAC AGAAAGAGTT CTAGCACCTG CTTCCACTCT GCAATCCAGT 
TACCAGATTC CCACTGAAAA TTCTATGACG GCTAGGAACA CCACGGTGTC TGGAGCTGGA 
GTCCCTGGCC CTCTGCCAGA TTTTGGTTTA GAGGAATCTG GTCATTCTAA TTCTACCATA 
ACCACATCTT CCACCAGAGT TACCAAGCAT AGCACTGTAC AGCATTCTTA CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001934.2
CDS	76..3432
Translation	MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS

Target ORF information:

RefSeq Version	NM_001943.5
Organism	Homo sapiens(human)
Definition	Homo sapiens desmoglein 2 (DSG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001943.5

ORF Insert Sequence:

ATGGCGCGGA GCCCGGGACG CGCGTACGCC CTGCTGCTTC TCCTGATCTG CTTTAACGTT 
GGAAGTGGAC TTCACTTACA GGTCTTAAGC ACAAGAAATG AAAATAAGCT GCTTCCTAAA 
CATCCTCATT TAGTGCGGCA AAAGCGCGCC TGGATCACCG CCCCCGTGGC TCTTCGGGAG 
GGAGAGGATC TGTCCAAGAA GAATCCAATT GCCAAGATAC ATTCTGATCT TGCAGAAGAA 
AGAGGACTCA AAATTACTTA CAAATACACT GGAAAAGGGA TTACAGAGCC ACCTTTTGGT 
ATATTTGTCT TTAACAAAGA TACTGGAGAA CTGAATGTTA CCAGCATTCT TGATCGAGAA 
GAAACACCAT TTTTTCTGCT AACAGGTTAC GCTTTGGATG CAAGAGGAAA CAATGTAGAG 
AAACCCTTAG AGCTACGCAT TAAGGTTCTT GATATCAATG ACAACGAACC AGTGTTCACA 
CAGGATGTCT TTGTTGGGTC TGTTGAAGAG TTGAGTGCAG CACATACTCT TGTGATGAAA 
ATCAATGCAA CAGATGCAGA TGAGCCCAAT ACCCTGAATT CGAAAATTTC CTATAGAATC 
GTATCTCTGG AGCCTGCTTA TCCTCCAGTG TTCTACCTAA ATAAAGATAC AGGAGAGATT 
TATACAACCA GTGTTACCTT GGACAGAGAG GAACACAGCA GCTACACTTT GACAGTAGAA 
GCAAGAGATG GCAATGGAGA AGTTACAGAC AAACCTGTAA AACAAGCTCA AGTTCAGATT 
CGTATTTTGG ATGTCAATGA CAATATACCT GTAGTAGAAA ATAAAGTGCT TGAAGGGATG 
GTTGAAGAAA ATCAAGTCAA CGTAGAAGTT ACGCGCATAA AAGTGTTCGA TGCAGATGAA 
ATAGGTTCTG ATAATTGGCT GGCAAATTTT ACATTTGCAT CAGGAAATGA AGGAGGTTAT 
TTCCACATAG AAACAGATGC TCAAACTAAC GAAGGAATTG TGACCCTTAT TAAGGAAGTA 
GATTATGAAG AAATGAAGAA TCTTGACTTC AGTGTTATTG TCGCTAATAA AGCAGCTTTT 
CACAAGTCGA TTAGGAGTAA ATACAAGCCT ACACCCATTC CCATCAAGGT CAAAGTGAAA 
AATGTGAAAG AAGGCATTCA TTTTAAAAGC AGCGTCATCT CAATTTATGT TAGCGAGAGC 
ATGGATAGAT CAAGCAAAGG CCAAATAATT GGAAATTTTC AAGCTTTTGA TGAGGACACT 
GGACTACCAG CCCATGCAAG ATATGTAAAA TTAGAAGATA GAGATAATTG GATCTCTGTG 
GATTCTGTCA CATCTGAAAT TAAACTTGCA AAACTTCCTG ATTTTGAATC TAGATATGTT 
CAAAATGGCA CATACACTGT AAAGATTGTG GCCATATCAG AAGATTATCC TAGAAAAACC 
ATCACTGGCA CAGTCCTTAT CAATGTTGAA GACATCAACG ACAACTGTCC CACACTGATA 
GAGCCTGTGC AGACAATCTG TCACGATGCA GAGTATGTGA ATGTTACTGC AGAGGACCTG 
GATGGACACC CAAACAGTGG CCCTTTCAGT TTCTCCGTCA TTGACAAACC ACCTGGCATG 
GCAGAAAAAT GGAAAATAGC ACGCCAAGAA AGTACCAGTG TGCTGCTGCA ACAAAGTGAG 
AAAAAGCTTG GGAGAAGTGA AATTCAGTTC CTGATTTCAG ACAATCAGGG TTTTAGTTGT 
CCTGAAAAGC AGGTCCTTAC ACTCACAGTT TGTGAGTGTC TGCATGGCAG CGGCTGCAGG 
GAAGCACAGC ATGACTCCTA TGTGGGCCTG GGACCCGCAG CAATTGCGCT CATGATTTTG 
GCCTTTCTGC TCCTGCTATT GGTACCACTT TTACTGCTGA TGTGCCATTG CGGAAAGGGC 
GCCAAAGGCT TTACCCCCAT ACCTGGCACC ATAGAGATGC TGCATCCTTG GAATAATGAA 
GGAGCACCAC CTGAAGACAA GGTGGTGCCA TCATTTCTGC CAGTGGATCA AGGGGGCAGT 
CTAGTAGGAA GAAATGGAGT AGGAGGTATG GCCAAGGAAG CCACGATGAA AGGAAGTAGC 
TCTGCTTCCA TTGTCAAAGG GCAACATGAG ATGTCCGAGA TGGATGGAAG GTGGGAAGAA 
CACAGAAGCC TGCTTTCTGG TAGAGCTACC CAGTTTACAG GGGCCACAGG CGCTATCATG 
ACCACTGAAA CCACGAAGAC CGCAAGGGCC ACAGGGGCTT CCAGAGACAT GGCCGGAGCT 
CAGGCAGCTG CTGTTGCACT GAACGAAGAA TTCTTAAGAA ATTATTTCAC TGATAAAGCG 
GCCTCTTACA CTGAGGAAGA TGAAAATCAC ACAGCCAAAG ATTGCCTTCT GGTTTATTCT 
CAGGAAGAAA CTGAATCGCT GAATGCTTCT ATTGGTTGTT GCAGTTTTAT TGAAGGAGAG 
CTAGATGACC GCTTCTTAGA TGATTTGGGA CTTAAATTCA AGACACTAGC TGAAGTTTGC 
CTGGGTCAAA AAATAGATAT AAATAAGGAA ATTGAGCAGA GACAAAAACC TGCCACAGAA 
ACAAGTATGA ACACAGCTTC ACATTCACTC TGTGAGCAAA CTATGGTTAA TTCAGAGAAT 
ACCTACTCCT CTGGCAGTAG CTTCCCAGTT CCAAAATCTT TGCAAGAAGC CAATGCAGAG 
AAAGTAACTC AGGAAATAGT CACTGAAAGA TCTGTGTCTT CTAGGCAGGC GCAAAAGGTA 
GCTACACCTC TTCCTGACCC AATGGCTTCT AGAAATGTGA TAGCAACAGA AACTTCCTAT 
GTCACAGGGT CCACTATGCC ACCAACCACT GTGATCCTGG GTCCTAGCCA GCCACAGAGC 
CTTATTGTGA CAGAGAGGGT GTATGCTCCA GCTTCTACCT TGGTAGATCA GCCTTATGCT 
AATGAAGGTA CAGTTGTGGT CACTGAAAGA GTAATACAGC CTCATGGGGG TGGATCGAAT 
CCTCTGGAAG GCACTCAGCA TCTTCAAGAT GTACCTTACG TCATGGTGAG GGAAAGAGAG 
AGCTTCCTTG CCCCCAGCTC AGGTGTGCAG CCTACTCTGG CCATGCCTAA TATAGCAGTA 
GGACAGAATG TGACAGTGAC AGAAAGAGTT CTAGCACCTG CTTCCACTCT GCAATCCAGT 
TACCAGATTC CCACTGAAAA TTCTATGACG GCTAGGAACA CCACGGTGTC TGGAGCTGGA 
GTCCCTGGCC CTCTGCCAGA TTTTGGTTTA GAGGAATCTG GTCATTCTAA TTCTACCATA 
ACCACATCTT CCACCAGAGT TACCAAGCAT AGCACTGTAC AGCATTCTTA CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A common indel polymorphism of the Desmoglein-2 (DSG2) is associated with sudden cardiac death in Chinese populations.
Forensic science international301382-387(2019 Aug)
Zou Y,Zhang Q,Zhang J,Chen X,Zhou W,Yang Z,Yang Q,Yu H,Li L,He Y,Li C,Zhang S,Zhu S,Luo B,Gao Y

CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement.
Nature communications10(1)1181(2019 03)
Vassal-Stermann E,Effantin G,Zubieta C,Burmeister W,Iseni F,Wang H,Lieber A,Schoehn G,Fender P

A founder homozygous DSG2 variant in East Asia results in ARVC with full penetrance and heart failure phenotype.
International journal of cardiology274263-270(2019 Jan)
Chen L,Rao M,Chen X,Chen K,Ren J,Zhang N,Zhao Q,Yu W,Yuan B,Song J

Disturbed Desmoglein-2 in the intercalated disc of pediatric patients with dilated cardiomyopathy.
Human pathology67101-108(2017 09)
Kessler EL,Nikkels PG,van Veen TA

Case reports of two pedigrees with recessive arrhythmogenic right ventricular cardiomyopathy associated with homozygous Thr335Ala variant in DSG2.
BMC medical genetics18(1)86(2017 08)
Qadri S,Anttonen O,Viikilä J,Seppälä EH,Myllykangas S,Alastalo TP,Holmström M,Heliö T,Koskenvuo JW

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DSG2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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