| Gene Symbol | DCN |
| Entrez Gene ID | 1634 |
| Full Name | decorin |
| Synonyms | CSCD,DSPG2,PG40,PGII,PGS2,SLRR1B |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(Human) |
| Genome | |
| Summary | This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]. |
| Disorder MIM: | |
| Disorder Html: | Corneal dystrophy, congenital stromal, 610048 (3) |
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