| Gene Symbol | GDF7 |
| Entrez Gene ID | 151449 |
| Full Name | growth differentiation factor 7 |
| Synonyms | BMP12 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]. |
| Disorder MIM: |
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GDF7 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following GDF7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDF7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu30270 Clone ID Related Accession (Same CDS sequence) NM_182828.4 , NM_182828.3 Accession Version NM_182828.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1353bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577635200000 Organism Homo sapiens(human) Product growth/differentiation factor 7 preproprotein Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF522369.1, AB158468.1, AC012065.8 and BQ182131.1. On Nov 23, 2018 this sequence version replaced NM_182828.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF522369.1, AB158468.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000272224.5/ ENSP00000272224.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321ATGGACCTGA GCGCCGCCGC CGCGCTGTGC CTTTGGCTGC TGAGCGCCTG CCGCCCCCGC
GACGGGCTGG AAGCGGCCGC CGTGCTGCGA GCGGCGGGGG CTGGGCCGGT CCGGAGCCCA
GGGGGCGGCG GCGGCGGCGG CGGCGGCGGG CGGACTCTTG CCCAGGCTGC GGGCGCCGCG
GCTGTCCCGG CCGCCGCGGT TCCCCGGGCC CGCGCCGCGC GCCGCGCCGC GGGCTCCGGC
TTCAGGAACG GCTCGGTGGT GCCGCACCAC TTCATGATGT CGCTTTACCG GAGCCTGGCC
GGGAGGGCTC CGGCCGGGGC AGCCGCTGTC TCCGCCTCGG GCCATGGTCG CGCGGACACG
ATCACCGGCT TCACAGACCA GGCGACCCAA GACGAATCGG CAGCCGAAAC AGGCCAGAGC
TTCCTGTTCG ACGTGTCCAG CCTTAACGAC GCAGACGAGG TGGTGGGTGC CGAGCTGCGC
GTGCTGCGCC GGGGATCTCC AGAGTCGGGC CCAGGCAGCT GGACTTCTCC GCCGTTGCTG
CTGCTGTCCA CGTGCCCGGG CGCCGCCCGA GCGCCACGCC TGCTGTACTC GCGGGCAGCT
GAGCCCCTAG TCGGTCAGCG CTGGGAGGCG TTCGACGTGG CGGACGCCAT GAGGCGCCAC
CGTCGTGAAC CGCGCCCCCC CCGCGCGTTC TGCCTCTTGC TGCGCGCAGT GGCAGGCCCG
GTGCCGAGCC CGTTGGCACT GCGGCGGCTG GGCTTCGGCT GGCCGGGCGG AGGGGGCTCT
GCGGCAGAGG AGCGCGCGGT GCTAGTCGTC TCCTCCCGCA CGCAGAGGAA AGAGAGCTTA
TTCCGGGAGA TCCGCGCCCA GGCCCGCGCG CTCGGGGCCG CTCTGGCCTC AGAGCCGCTG
CCCGACCCAG GAACCGGCAC CGCGTCGCCA AGGGCAGTCA TTGGCGGCCG CAGACGGAGG
AGGACGGCGT TGGCCGGGAC GCGGACAGCG CAGGGCAGCG GCGGGGGCGC GGGCCGGGGC
CACGGGCGCA GGGGCCGGAG CCGCTGCAGC CGCAAGCCGT TGCACGTGGA CTTCAAGGAG
CTCGGCTGGG ACGACTGGAT CATCGCGCCG CTGGACTACG AGGCGTACCA CTGCGAGGGC
CTTTGCGACT TCCCTTTGCG TTCGCACCTC GAGCCCACCA ACCATGCCAT CATTCAGACG
CTGCTCAACT CCATGGCACC AGACGCGGCG CCGGCCTCCT GCTGTGTGCC AGCGCGCCTC
AGCCCCATCA GCATCCTCTA CATCGACGCC GCCAACAACG TTGTCTACAA GCAATACGAG
GACATGGTGG TGGAGGCCTG CGGCTGCAGG TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_878248.2 CDS 97..1449 Translation 
Target ORF information:
RefSeq Version NM_182828.4 Organism Homo sapiens(human) Definition Homo sapiens growth differentiation factor 7 (GDF7), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_182828.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321ATGGACCTGA GCGCCGCCGC CGCGCTGTGC CTTTGGCTGC TGAGCGCCTG CCGCCCCCGC
GACGGGCTGG AAGCGGCCGC CGTGCTGCGA GCGGCGGGGG CTGGGCCGGT CCGGAGCCCA
GGGGGCGGCG GCGGCGGCGG CGGCGGCGGG CGGACTCTTG CCCAGGCTGC GGGCGCCGCG
GCTGTCCCGG CCGCCGCGGT TCCCCGGGCC CGCGCCGCGC GCCGCGCCGC GGGCTCCGGC
TTCAGGAACG GCTCGGTGGT GCCGCACCAC TTCATGATGT CGCTTTACCG GAGCCTGGCC
GGGAGGGCTC CGGCCGGGGC AGCCGCTGTC TCCGCCTCGG GCCATGGTCG CGCGGACACG
ATCACCGGCT TCACAGACCA GGCGACCCAA GACGAATCGG CAGCCGAAAC AGGCCAGAGC
TTCCTGTTCG ACGTGTCCAG CCTTAACGAC GCAGACGAGG TGGTGGGTGC CGAGCTGCGC
GTGCTGCGCC GGGGATCTCC AGAGTCGGGC CCAGGCAGCT GGACTTCTCC GCCGTTGCTG
CTGCTGTCCA CGTGCCCGGG CGCCGCCCGA GCGCCACGCC TGCTGTACTC GCGGGCAGCT
GAGCCCCTAG TCGGTCAGCG CTGGGAGGCG TTCGACGTGG CGGACGCCAT GAGGCGCCAC
CGTCGTGAAC CGCGCCCCCC CCGCGCGTTC TGCCTCTTGC TGCGCGCAGT GGCAGGCCCG
GTGCCGAGCC CGTTGGCACT GCGGCGGCTG GGCTTCGGCT GGCCGGGCGG AGGGGGCTCT
GCGGCAGAGG AGCGCGCGGT GCTAGTCGTC TCCTCCCGCA CGCAGAGGAA AGAGAGCTTA
TTCCGGGAGA TCCGCGCCCA GGCCCGCGCG CTCGGGGCCG CTCTGGCCTC AGAGCCGCTG
CCCGACCCAG GAACCGGCAC CGCGTCGCCA AGGGCAGTCA TTGGCGGCCG CAGACGGAGG
AGGACGGCGT TGGCCGGGAC GCGGACAGCG CAGGGCAGCG GCGGGGGCGC GGGCCGGGGC
CACGGGCGCA GGGGCCGGAG CCGCTGCAGC CGCAAGCCGT TGCACGTGGA CTTCAAGGAG
CTCGGCTGGG ACGACTGGAT CATCGCGCCG CTGGACTACG AGGCGTACCA CTGCGAGGGC
CTTTGCGACT TCCCTTTGCG TTCGCACCTC GAGCCCACCA ACCATGCCAT CATTCAGACG
CTGCTCAACT CCATGGCACC AGACGCGGCG CCGGCCTCCT GCTGTGTGCC AGCGCGCCTC
AGCCCCATCA GCATCCTCTA CATCGACGCC GCCAACAACG TTGTCTACAA GCAATACGAG
GACATGGTGG TGGAGGCCTG CGGCTGCAGG TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu30270 Clone ID Related Accession (Same CDS sequence) NM_182828.4 , NM_182828.3 Accession Version NM_182828.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1353bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506960000000 Organism Homo sapiens(human) Product growth/differentiation factor 7 preproprotein Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF522369.1, AB158468.1, AC012065.8 and BQ182131.1. On May 13, 2016 this sequence version replaced NM_182828.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF522369.1, AB158468.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321ATGGACCTGA GCGCCGCCGC CGCGCTGTGC CTTTGGCTGC TGAGCGCCTG CCGCCCCCGC
GACGGGCTGG AAGCGGCCGC CGTGCTGCGA GCGGCGGGGG CTGGGCCGGT CCGGAGCCCA
GGGGGCGGCG GCGGCGGCGG CGGCGGCGGG CGGACTCTTG CCCAGGCTGC GGGCGCCGCG
GCTGTCCCGG CCGCCGCGGT TCCCCGGGCC CGCGCCGCGC GCCGCGCCGC GGGCTCCGGC
TTCAGGAACG GCTCGGTGGT GCCGCACCAC TTCATGATGT CGCTTTACCG GAGCCTGGCC
GGGAGGGCTC CGGCCGGGGC AGCCGCTGTC TCCGCCTCGG GCCATGGTCG CGCGGACACG
ATCACCGGCT TCACAGACCA GGCGACCCAA GACGAATCGG CAGCCGAAAC AGGCCAGAGC
TTCCTGTTCG ACGTGTCCAG CCTTAACGAC GCAGACGAGG TGGTGGGTGC CGAGCTGCGC
GTGCTGCGCC GGGGATCTCC AGAGTCGGGC CCAGGCAGCT GGACTTCTCC GCCGTTGCTG
CTGCTGTCCA CGTGCCCGGG CGCCGCCCGA GCGCCACGCC TGCTGTACTC GCGGGCAGCT
GAGCCCCTAG TCGGTCAGCG CTGGGAGGCG TTCGACGTGG CGGACGCCAT GAGGCGCCAC
CGTCGTGAAC CGCGCCCCCC CCGCGCGTTC TGCCTCTTGC TGCGCGCAGT GGCAGGCCCG
GTGCCGAGCC CGTTGGCACT GCGGCGGCTG GGCTTCGGCT GGCCGGGCGG AGGGGGCTCT
GCGGCAGAGG AGCGCGCGGT GCTAGTCGTC TCCTCCCGCA CGCAGAGGAA AGAGAGCTTA
TTCCGGGAGA TCCGCGCCCA GGCCCGCGCG CTCGGGGCCG CTCTGGCCTC AGAGCCGCTG
CCCGACCCAG GAACCGGCAC CGCGTCGCCA AGGGCAGTCA TTGGCGGCCG CAGACGGAGG
AGGACGGCGT TGGCCGGGAC GCGGACAGCG CAGGGCAGCG GCGGGGGCGC GGGCCGGGGC
CACGGGCGCA GGGGCCGGAG CCGCTGCAGC CGCAAGCCGT TGCACGTGGA CTTCAAGGAG
CTCGGCTGGG ACGACTGGAT CATCGCGCCG CTGGACTACG AGGCGTACCA CTGCGAGGGC
CTTTGCGACT TCCCTTTGCG TTCGCACCTC GAGCCCACCA ACCATGCCAT CATTCAGACG
CTGCTCAACT CCATGGCACC AGACGCGGCG CCGGCCTCCT GCTGTGTGCC AGCGCGCCTC
AGCCCCATCA GCATCCTCTA CATCGACGCC GCCAACAACG TTGTCTACAA GCAATACGAG
GACATGGTGG TGGAGGCCTG CGGCTGCAGG TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_878248.2 CDS 577..1929 Translation
Target ORF information:
RefSeq Version NM_182828.3 Organism Homo sapiens(human) Definition Homo sapiens growth differentiation factor 7 (GDF7), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_182828.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321ATGGACCTGA GCGCCGCCGC CGCGCTGTGC CTTTGGCTGC TGAGCGCCTG CCGCCCCCGC
GACGGGCTGG AAGCGGCCGC CGTGCTGCGA GCGGCGGGGG CTGGGCCGGT CCGGAGCCCA
GGGGGCGGCG GCGGCGGCGG CGGCGGCGGG CGGACTCTTG CCCAGGCTGC GGGCGCCGCG
GCTGTCCCGG CCGCCGCGGT TCCCCGGGCC CGCGCCGCGC GCCGCGCCGC GGGCTCCGGC
TTCAGGAACG GCTCGGTGGT GCCGCACCAC TTCATGATGT CGCTTTACCG GAGCCTGGCC
GGGAGGGCTC CGGCCGGGGC AGCCGCTGTC TCCGCCTCGG GCCATGGTCG CGCGGACACG
ATCACCGGCT TCACAGACCA GGCGACCCAA GACGAATCGG CAGCCGAAAC AGGCCAGAGC
TTCCTGTTCG ACGTGTCCAG CCTTAACGAC GCAGACGAGG TGGTGGGTGC CGAGCTGCGC
GTGCTGCGCC GGGGATCTCC AGAGTCGGGC CCAGGCAGCT GGACTTCTCC GCCGTTGCTG
CTGCTGTCCA CGTGCCCGGG CGCCGCCCGA GCGCCACGCC TGCTGTACTC GCGGGCAGCT
GAGCCCCTAG TCGGTCAGCG CTGGGAGGCG TTCGACGTGG CGGACGCCAT GAGGCGCCAC
CGTCGTGAAC CGCGCCCCCC CCGCGCGTTC TGCCTCTTGC TGCGCGCAGT GGCAGGCCCG
GTGCCGAGCC CGTTGGCACT GCGGCGGCTG GGCTTCGGCT GGCCGGGCGG AGGGGGCTCT
GCGGCAGAGG AGCGCGCGGT GCTAGTCGTC TCCTCCCGCA CGCAGAGGAA AGAGAGCTTA
TTCCGGGAGA TCCGCGCCCA GGCCCGCGCG CTCGGGGCCG CTCTGGCCTC AGAGCCGCTG
CCCGACCCAG GAACCGGCAC CGCGTCGCCA AGGGCAGTCA TTGGCGGCCG CAGACGGAGG
AGGACGGCGT TGGCCGGGAC GCGGACAGCG CAGGGCAGCG GCGGGGGCGC GGGCCGGGGC
CACGGGCGCA GGGGCCGGAG CCGCTGCAGC CGCAAGCCGT TGCACGTGGA CTTCAAGGAG
CTCGGCTGGG ACGACTGGAT CATCGCGCCG CTGGACTACG AGGCGTACCA CTGCGAGGGC
CTTTGCGACT TCCCTTTGCG TTCGCACCTC GAGCCCACCA ACCATGCCAT CATTCAGACG
CTGCTCAACT CCATGGCACC AGACGCGGCG CCGGCCTCCT GCTGTGTGCC AGCGCGCCTC
AGCCCCATCA GCATCCTCTA CATCGACGCC GCCAACAACG TTGTCTACAA GCAATACGAG
GACATGGTGG TGGAGGCCTG CGGCTGCAGG TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
-
PubMed
Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties.
BMC cell biology18(1)13(2017 02)
Zarychta-Wiśniewska W,Burdzinska A,Kulesza A,Gala K,Kaleta B,Zielniok K,Siennicka K,Sabat M,Paczek L
The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.
Cancer medicine5(5)888-91(2016 05)
Becker J,May A,Gerges C,Anders M,Schmidt C,Veits L,Noder T,Mayershofer R,Kreuser N,Manner H,Venerito M,Hofer JH,Lyros O,Ahlbrand CJ,Arras M,Hofer S,Heinrichs SK,Weise K,Hess T,Böhmer AC,Kosiol N,Kiesslich R,Izbicki JR,Hölscher AH,Bollschweiler E,Malfertheiner P,Lang H,Moehler M,Lorenz D,Ott K,Schmidt T,Nöthen MM,Hackelsberger A,Schumacher B,Pech O,Vashist Y,Vieth M,Weismüller J,Knapp M,Neuhaus H,Rösch T,Ell C,Gockel I,Schumacher J
Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society34(4)630-40(2016 Apr)
Gelberman RH,Shen H,Kormpakis I,Rothrauff B,Yang G,Tuan RS,Xia Y,Sakiyama-Elbert S,Silva MJ,Thomopoulos S
Local rhBMP-12 on an Absorbable Collagen Sponge as an Adjuvant Therapy for Rotator Cuff Repair - A Phase 1, Randomized, Standard of Care Control, Multicenter Study: Safety and Feasibility.
The American journal of sports medicine43(8)1994-2004(2015 Aug)
Greiner S,Ide J,Van Noort A,Mochizuki Y,Ochi H,Marraffino S,Sridharan S,Rudicel S,Itoi E
Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.
Gastroenterology148(2)367-78(2015 Feb)
Palles C,Chegwidden L,Li X,Findlay JM,Farnham G,Castro Giner F,Peppelenbosch MP,Kovac M,Adams CL,Prenen H,Briggs S,Harrison R,Sanders S,MacDonald D,Haigh C,Tucker A,Love S,Nanji M,deCaestecker J,Ferry D,Rathbone B,Hapeshi J,Barr H,Moayyedi P,Watson P,Zietek B,Maroo N,Gay L,Underwood T,Boulter L,McMurtry H,Monk D,Patel P,Ragunath K,Al Dulaimi D,Murray I,Koss K,Veitch A,Trudgill N,Nwokolo C,Rembacken B,Atherfold P,Green E,Ang Y,Kuipers EJ,Chow W,Paterson S,Kadri S,Beales I,Grimley C,Mullins P,Beckett C,Farrant M,Dixon A,Kelly S,Johnson M,Wajed S,Dhar A,Sawyer E,Roylance R,Onstad L,Gammon MD,Corley DA,Shaheen NJ,Bird NC,Hardie LJ,Reid BJ,Ye W,Liu G,Romero Y,Bernstein L,Wu AH,Casson AG,Fitzgerald R,Whiteman DC,Risch HA,Levine DM,Vaughan TL,Verhaar AP,van den Brande J,Toxopeus EL,Spaander MC,Wijnhoven BP,van der Laan LJ,Krishnadath K,Wijmenga C,Trynka G,McManus R,Reynolds JV,O'Sullivan J,MacMathuna P,McGarrigle SA,Kelleher D,Vermeire S,Cleynen I,Bisschops R,Tomlinson I,Jankowski J
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