| Gene Symbol | ACTRT1 |
| Entrez Gene ID | 139741 |
| Full Name | actin related protein T1 |
| Synonyms | AIP1,ARIP1,ARPT1,HSD27 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a protein related to the cytoskeletal protein beta-actin. This protein is a major component of the calyx in the perinuclear theca of mammalian sperm heads, and it therefore likely functions in spermatid formation. This gene is intronless and is similar to a related gene located on chromosome 1. A related pseudogene has also been identified approximately 75 kb downstream of this gene on chromosome X. [provided by RefSeq, May 2010]. |
| Disorder MIM: |
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ACTRT1 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following ACTRT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACTRT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu18276 Clone ID Related Accession (Same CDS sequence) NM_138289.3 Accession Version NM_138289.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1131bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1569168000000 Organism Homo sapiens(human) Product actin-related protein T1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB452140.1, BC014597.1 and DB510229.1. This sequence is a reference standard in the RefSeqGene project. On Apr 10, 2009 this sequence version replaced NM_138289.2. ##Evidence-Data-START## Transcript is intronless :: BC014597.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGTTTAATC CACATGCATT AGATGTTCCT GCTGTAATTT TTGACAATGG TTCAGGACTC
TGCAAAGCAG GCCTGTCTGG AGAGATTGGA CCCCGCCATG TCATCAGCTC CGTCTTGGGA
CATTGTAAAT TCAATGTGCC TTTAGCAAGA CTTAATCAGA AGTACTTCGT GGGGCAAGAA
GCCCTGTACA AGTATGAGGC CCTACATTTG CACTACCCCA TTGAGCGTGG ACTGGTAACA
GGATGGGATG ACATGGAGAA ACTCTGGAAA CATCTCTTTG AGCGGGAGCT TGGAGTAAAA
CCCAGCCAAC AGCCTGTACT TATGACCGAG CCCTCTTTGA ATCCTAGGGA AATTCGAGAA
AAGCTAGCAG AAATGATGTT TGAGACCTTC AGTGTGCCTG GTTTCTACCT GTCTAATCAT
GCGGTGGCAG CGCTCTATGC CTCTGCCTGT GTCACAGGCC TGGTGGTGGA CAGTGGAGAT
GGGGTCACTT GCACTGTCCC CATCTTTGAG GGTTACTCCC TGCCTCACGC AGTCACCAAA
CTCTGTATGG CAGGGAGGGA CATCACAGAG CACCTCACCC GGCTCCTCTT TGCTAGCGGG
TTTAACTTCC CTTGCATACT CAACAAGGCC GTGGTAAATA ACATCAAAGA GAAGTTGTGC
TACATCGCCT TGGAGCCAGA GAAAGAGCTA CGCAAGAGCC GGGGAGAGGT CCTGGGAGCA
TACAGACTGC CAGATGGACA TGTCATCCAC TTTGGGGATG AGCTGTACCA AGTGCCCGAG
GTTCTTTTTG CACCTGACCA GCTGGGCATC CACAGCCCAG GACTCTCAAA AATGGTCTCC
AGCAGCATCA TGAAGTGTGA CACTGACATC CAGAATAAAC TTTATGCAGA CATTGTACTC
TCCGGGGGCA CCACTCTCCT CCCTGGGCTG GAGGAAAGGC TCATGAAGGA AGTGGAACAG
CTGGCTTCCA AAGGTACTCC CATCAAGATC ACAGCTTCTC CTGATAGATG CTTCTCTGCA
TGGATTGGTG CATCCATCAT GACCTCTATG AGCAGTTTCA AGCAGATGTG GGTCACCTCG
GCAGACTTCA AGGAGTATGG GACATCTGTG GTTCAAAGAA GGTGCTTTTA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_612146.1 CDS 198..1328 Translation 
Target ORF information:
RefSeq Version NM_138289.3 Organism Homo sapiens(human) Definition Homo sapiens actin related protein T1 (ACTRT1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_138289.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGTTTAATC CACATGCATT AGATGTTCCT GCTGTAATTT TTGACAATGG TTCAGGACTC
TGCAAAGCAG GCCTGTCTGG AGAGATTGGA CCCCGCCATG TCATCAGCTC CGTCTTGGGA
CATTGTAAAT TCAATGTGCC TTTAGCAAGA CTTAATCAGA AGTACTTCGT GGGGCAAGAA
GCCCTGTACA AGTATGAGGC CCTACATTTG CACTACCCCA TTGAGCGTGG ACTGGTAACA
GGATGGGATG ACATGGAGAA ACTCTGGAAA CATCTCTTTG AGCGGGAGCT TGGAGTAAAA
CCCAGCCAAC AGCCTGTACT TATGACCGAG CCCTCTTTGA ATCCTAGGGA AATTCGAGAA
AAGCTAGCAG AAATGATGTT TGAGACCTTC AGTGTGCCTG GTTTCTACCT GTCTAATCAT
GCGGTGGCAG CGCTCTATGC CTCTGCCTGT GTCACAGGCC TGGTGGTGGA CAGTGGAGAT
GGGGTCACTT GCACTGTCCC CATCTTTGAG GGTTACTCCC TGCCTCACGC AGTCACCAAA
CTCTGTATGG CAGGGAGGGA CATCACAGAG CACCTCACCC GGCTCCTCTT TGCTAGCGGG
TTTAACTTCC CTTGCATACT CAACAAGGCC GTGGTAAATA ACATCAAAGA GAAGTTGTGC
TACATCGCCT TGGAGCCAGA GAAAGAGCTA CGCAAGAGCC GGGGAGAGGT CCTGGGAGCA
TACAGACTGC CAGATGGACA TGTCATCCAC TTTGGGGATG AGCTGTACCA AGTGCCCGAG
GTTCTTTTTG CACCTGACCA GCTGGGCATC CACAGCCCAG GACTCTCAAA AATGGTCTCC
AGCAGCATCA TGAAGTGTGA CACTGACATC CAGAATAAAC TTTATGCAGA CATTGTACTC
TCCGGGGGCA CCACTCTCCT CCCTGGGCTG GAGGAAAGGC TCATGAAGGA AGTGGAACAG
CTGGCTTCCA AAGGTACTCC CATCAAGATC ACAGCTTCTC CTGATAGATG CTTCTCTGCA
TGGATTGGTG CATCCATCAT GACCTCTATG AGCAGTTTCA AGCAGATGTG GGTCACCTCG
GCAGACTTCA AGGAGTATGG GACATCTGTG GTTCAAAGAA GGTGCTTTTA AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas.
Nature medicine23(10)1226-1233(2017 Oct)
Bal E,Park HS,Belaid-Choucair Z,Kayserili H,Naville M,Madrange M,Chiticariu E,Hadj-Rabia S,Cagnard N,Kuonen F,Bachmann D,Huber M,Le Gall C,Côté F,Hanein S,Rosti RÖ,Aslanger AD,Waisfisz Q,Bodemer C,Hermine O,Morice-Picard F,Labeille B,Caux F,Mazereeuw-Hautier J,Philip N,Levy N,Taieb A,Avril MF,Headon DJ,Gyapay G,Magnaldo T,Fraitag S,Crollius HR,Vabres P,Hohl D,Munnich A,Smahi A
Image-based genome-wide siRNA screen identifies selective autophagy factors.
Nature480(7375)113-7(2011 Dec)
Orvedahl A,Sumpter R Jr,Xiao G,Ng A,Zou Z,Tang Y,Narimatsu M,Gilpin C,Sun Q,Roth M,Forst CV,Wrana JL,Zhang YE,Luby-Phelps K,Xavier RJ,Xie Y,Levine B
Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head.
Experimental cell research279(2)177-87(2002 Oct)
Heid H,Figge U,Winter S,Kuhn C,Zimbelmann R,Franke W
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