NAXE cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NAXE
Entrez Gene ID	128240
Full Name	NAD(P)HX epimerase
Synonyms	AIBP,APOA1BP,PEBEL,YJEFN1
General protein information	Preferred Names NAD(P)HX epimerase Names NAD(P)H-hydrate epimerase AI-BP apoA-I binding protein apolipoprotein A-I-binding protein yjeF N-terminal domain-containing protein 1 yjeF_N1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q22
Summary	The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008].
Disorder MIM:	608862
Disorder Html:	Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 617186 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017000319.1	XP_016855808.1	NAD(P)H-hydrate epimerase isoform X1
XM_017000319.2	XP_016855808.1	NAD(P)H-hydrate epimerase isoform X1
NM_144772.2	NP_658985.2	NAD(P)H-hydrate epimerase precursor
NM_144772.3	NP_658985.2	NAD(P)H-hydrate epimerase precursor

Pathways from BioSystems

Homologies

Magnaporthe oryzae (rice blast fungus)	MGG_02597	XP_003721201.1
Saccharomyces cerevisiae (baker's yeast)	YNL200C	NP_014199.1
Homo sapiens (human)	APOA1BP	NP_658985.2
Pan troglodytes (chimpanzee)	APOA1BP	XP_513889.1
Neurospora crassa	NCU08070	XP_965201.1
Macaca mulatta (Rhesus monkey)	LOC718532	XP_001116635.2
Xenopus tropicalis (tropical clawed frog)	apoa1bp	XP_002938991.2
Oryza sativa (rice)	Os10g0377800	NP_001064477.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003324	XP_319557.4
Schizosaccharomyces pombe (fission yeast)	mug182	NP_594292.1
Bos taurus (cattle)	APOA1BP	NP_991365.1
Mus musculus (house mouse)	Apoa1bp	NP_659146.1
Danio rerio (zebrafish)	apoa1bp	NP_001002618.1
Drosophila melanogaster (fruit fly)	CG2974	NP_572604.2
Eremothecium gossypii	AGOS_ABL161C	NP_982786.1
Rattus norvegicus (Norway rat)	Apoa1bp	NP_001099910.1
Caenorhabditis elegans (roundworm)	CELE_Y18D10A.3	NP_493241.1
Arabidopsis thaliana (thale cress)	PPOX	NP_568717.2
Kluyveromyces lactis	KLLA0F20768g	XP_456012.1
Canis lupus familiaris (dog)	APOA1BP	XP_854934.3

Gene Ontology
Bibliography

Related articles in PubMed

AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation.
Choi SH, Wallace AM, Schneider DA, Burg E, Kim J, Alekseeva E, Ubags ND, Cool CD, Fang L, Suratt BT, Miller YI
JCI insight3(16)(2018 08)

[Clinical and genetic features of early-onset progressive encephalopathy associated with NAXE gene mutations].
Yu D, Zhao FM, Cai XT, Zhou H, Cheng Y
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics20(7)524-258(2018 Jul)

Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function.
Niehaus TD, Elbadawi-Sidhu M, Huang L, Prunetti L, Gregory JF 3rd, de Crécy-Lagard V, Fiehn O, Hanson AD
Bioscience reports38(3)(2018 06)

Apolipoprotein A-1 Binding Protein Inhibits Inflammatory Signaling Pathways by Binding to Apolipoprotein A-1 in THP-1 Macrophages.
Zhang M, Zhao GJ, Yin K, Xia XD, Gong D, Zhao ZW, Chen LY, Zheng XL, Tang XE, Tang CK
Circulation journal : official journal of the Japanese Circulation Society82(5)1396-1404(2018 04)

NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood.
Kremer LS, Danhauser K, Herebian D, Petkovic Ramadža D, Piekutowska-Abramczuk D, Seibt A, Müller-Felber W, Haack TB, Płoski R, Lohmeier K, Schneider D, Klee D, Rokicki D, Mayatepek E, Strom TM, Meitinger T, Klopstock T, Pronicka E, Mayr JA, Baric I, Distelmaier F, Prokisch H
American journal of human genetics99(4)894-902(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following NAXE gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NAXE cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu83140	XM_017000319.2 Latest version!	Homo sapiens NAD(P)HX epimerase (NAXE), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu30002	NM_144772.3 Latest version!	Homo sapiens NAD(P)HX epimerase (NAXE), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
View Old Accession Versions >>
OHu83140	XM_017000319.1	Homo sapiens NAD(P)HX epimerase (NAXE), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu30002	NM_144772.2	Homo sapiens NAD(P)HX epimerase (NAXE), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NAXE ( XM_017000319.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016855808.1 Homo sapiens NAD(P)HX epimerase (NAXE), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu83140
Clone ID Related Accession (Same CDS sequence)	XM_017000319.1 , XM_017000319.2
Accession Version	XM_017000319.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	NAD(P)H-hydrate epimerase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGGC TGCGGGCGCT GCTGGGCCTC GGGCTGCTGG TTGCGGGCTC GCGCGTGCCG 
CGGATCAAAA GCCAGACCAT CGCCTGTCGC TCGGGACCCA CCTGGTGGGG ACCGCAGCGG 
CTGAACTCGG GTGGCCGCTG GGACTCAGAG GTCATGGCGA GCACGGTGGT GAAGTACCTG 
AGCCAGGAGG AGGCCCAGGC CGTGGACCAG GAGCTATTTA ACGAATACCA GTTCAGCGTG 
GACCAACTTA TGGAACTGGC CGGGCTGAGC TGTGCTACAG CCATCGCCAA GGCATATCCC 
CCCACGTCCA TGTCCAGGAG CCCCCCTACT GTCCTGGTCA TCTGTGGCCC GGGGAATAAT 
GGAGGAGATG GTCTGGTCTG TGCTCGACAC CTCAAACTCT TTGGCTACGA GCCAACCATC 
TATTACCCCA AAAGGCCTAA CAAGCCCCTC TTCACTGCAT TGGTGACCCA GTGTCAGAAA 
ATGGACATCC CTTTCCTTGG GGAAATGCCC GCAGAGCCCA TGACGATTGA TGAACTGTAT 
GAGCTGGTGG TGGATGCCAT CTTTGGCTTC AGCTTCAAGG GCGATGTTCG GGAACCGTTC 
CACAGCATCC TGAGTGTCCT GAAGGGACTC ACTGTGCCCA TTGCCAGCAT CGACATTCCC 
TCAGGTGCTG GGATCCAGAA GCTGGCTGGT GAGCAGAACA AGAAGAGGAA ATGCTCTGGT 
TCATCAGGTC TTCACAGTGG ACAAGTGCCA GTGACTGACA GTAAAGATGC CCCGCTCCAC 
CCCGACCATA GTACCTGTTC ACAGTACCTT CATTTAATCA GATTAATTGA GAGTCTACTA 
TGGGCCAAGG AGTTGGGGAT TCAGAGTGGA ATAAGAATGA GATGGGCCCA GCCCAGATGG 
AATCTACATA GGCAATTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016855808.1
CDS	44..964
Translation	MSRLRALLGLGLLVAGSRVPRIKSQTIACRSGPTWWGPQRLNSGGRWDSEVMASTVVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSRSPPTVLVICGPGNNGGDGLVCARHLKLFGYEPTIYYPKRPNKPLFTALVTQCQKMDIPFLGEMPAEPMTIDELYELVVDAIFGFSFKGDVREPFHSILSVLKGLTVPIASIDIPSGAGIQKLAGEQNKKRKCSGSSGLHSGQVPVTDSKDAPLHPDHSTCSQYLHLIRLIESLLWAKELGIQSGIRMRWAQPRWNLHRQL

Target ORF information:

RefSeq Version	XM_017000319.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NAD(P)HX epimerase (NAXE), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017000319.1

ORF Insert Sequence:

ATGTCCAGGC TGCGGGCGCT GCTGGGCCTC GGGCTGCTGG TTGCGGGCTC GCGCGTGCCG 
CGGATCAAAA GCCAGACCAT CGCCTGTCGC TCGGGACCCA CCTGGTGGGG ACCGCAGCGG 
CTGAACTCGG GTGGCCGCTG GGACTCAGAG GTCATGGCGA GCACGGTGGT GAAGTACCTG 
AGCCAGGAGG AGGCCCAGGC CGTGGACCAG GAGCTATTTA ACGAATACCA GTTCAGCGTG 
GACCAACTTA TGGAACTGGC CGGGCTGAGC TGTGCTACAG CCATCGCCAA GGCATATCCC 
CCCACGTCCA TGTCCAGGAG CCCCCCTACT GTCCTGGTCA TCTGTGGCCC GGGGAATAAT 
GGAGGAGATG GTCTGGTCTG TGCTCGACAC CTCAAACTCT TTGGCTACGA GCCAACCATC 
TATTACCCCA AAAGGCCTAA CAAGCCCCTC TTCACTGCAT TGGTGACCCA GTGTCAGAAA 
ATGGACATCC CTTTCCTTGG GGAAATGCCC GCAGAGCCCA TGACGATTGA TGAACTGTAT 
GAGCTGGTGG TGGATGCCAT CTTTGGCTTC AGCTTCAAGG GCGATGTTCG GGAACCGTTC 
CACAGCATCC TGAGTGTCCT GAAGGGACTC ACTGTGCCCA TTGCCAGCAT CGACATTCCC 
TCAGGTGCTG GGATCCAGAA GCTGGCTGGT GAGCAGAACA AGAAGAGGAA ATGCTCTGGT 
TCATCAGGTC TTCACAGTGG ACAAGTGCCA GTGACTGACA GTAAAGATGC CCCGCTCCAC 
CCCGACCATA GTACCTGTTC ACAGTACCTT CATTTAATCA GATTAATTGA GAGTCTACTA 
TGGGCCAAGG AGTTGGGGAT TCAGAGTGGA ATAAGAATGA GATGGGCCCA GCCCAGATGG 
AATCTACATA GGCAATTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NAXE ( XM_017000319.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016855808.1 Homo sapiens NAD(P)HX epimerase (NAXE), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu83140
Clone ID Related Accession (Same CDS sequence)	XM_017000319.1 , XM_017000319.2
Accession Version	XM_017000319.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	NAD(P)H-hydrate epimerase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017000319.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGGC TGCGGGCGCT GCTGGGCCTC GGGCTGCTGG TTGCGGGCTC GCGCGTGCCG 
CGGATCAAAA GCCAGACCAT CGCCTGTCGC TCGGGACCCA CCTGGTGGGG ACCGCAGCGG 
CTGAACTCGG GTGGCCGCTG GGACTCAGAG GTCATGGCGA GCACGGTGGT GAAGTACCTG 
AGCCAGGAGG AGGCCCAGGC CGTGGACCAG GAGCTATTTA ACGAATACCA GTTCAGCGTG 
GACCAACTTA TGGAACTGGC CGGGCTGAGC TGTGCTACAG CCATCGCCAA GGCATATCCC 
CCCACGTCCA TGTCCAGGAG CCCCCCTACT GTCCTGGTCA TCTGTGGCCC GGGGAATAAT 
GGAGGAGATG GTCTGGTCTG TGCTCGACAC CTCAAACTCT TTGGCTACGA GCCAACCATC 
TATTACCCCA AAAGGCCTAA CAAGCCCCTC TTCACTGCAT TGGTGACCCA GTGTCAGAAA 
ATGGACATCC CTTTCCTTGG GGAAATGCCC GCAGAGCCCA TGACGATTGA TGAACTGTAT 
GAGCTGGTGG TGGATGCCAT CTTTGGCTTC AGCTTCAAGG GCGATGTTCG GGAACCGTTC 
CACAGCATCC TGAGTGTCCT GAAGGGACTC ACTGTGCCCA TTGCCAGCAT CGACATTCCC 
TCAGGTGCTG GGATCCAGAA GCTGGCTGGT GAGCAGAACA AGAAGAGGAA ATGCTCTGGT 
TCATCAGGTC TTCACAGTGG ACAAGTGCCA GTGACTGACA GTAAAGATGC CCCGCTCCAC 
CCCGACCATA GTACCTGTTC ACAGTACCTT CATTTAATCA GATTAATTGA GAGTCTACTA 
TGGGCCAAGG AGTTGGGGAT TCAGAGTGGA ATAAGAATGA GATGGGCCCA GCCCAGATGG 
AATCTACATA GGCAATTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016855808.1
CDS	30..950
Translation	MSRLRALLGLGLLVAGSRVPRIKSQTIACRSGPTWWGPQRLNSGGRWDSEVMASTVVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSRSPPTVLVICGPGNNGGDGLVCARHLKLFGYEPTIYYPKRPNKPLFTALVTQCQKMDIPFLGEMPAEPMTIDELYELVVDAIFGFSFKGDVREPFHSILSVLKGLTVPIASIDIPSGAGIQKLAGEQNKKRKCSGSSGLHSGQVPVTDSKDAPLHPDHSTCSQYLHLIRLIESLLWAKELGIQSGIRMRWAQPRWNLHRQL

Target ORF information:

RefSeq Version	XM_017000319.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NAD(P)HX epimerase (NAXE), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017000319.2

ORF Insert Sequence:

ATGTCCAGGC TGCGGGCGCT GCTGGGCCTC GGGCTGCTGG TTGCGGGCTC GCGCGTGCCG 
CGGATCAAAA GCCAGACCAT CGCCTGTCGC TCGGGACCCA CCTGGTGGGG ACCGCAGCGG 
CTGAACTCGG GTGGCCGCTG GGACTCAGAG GTCATGGCGA GCACGGTGGT GAAGTACCTG 
AGCCAGGAGG AGGCCCAGGC CGTGGACCAG GAGCTATTTA ACGAATACCA GTTCAGCGTG 
GACCAACTTA TGGAACTGGC CGGGCTGAGC TGTGCTACAG CCATCGCCAA GGCATATCCC 
CCCACGTCCA TGTCCAGGAG CCCCCCTACT GTCCTGGTCA TCTGTGGCCC GGGGAATAAT 
GGAGGAGATG GTCTGGTCTG TGCTCGACAC CTCAAACTCT TTGGCTACGA GCCAACCATC 
TATTACCCCA AAAGGCCTAA CAAGCCCCTC TTCACTGCAT TGGTGACCCA GTGTCAGAAA 
ATGGACATCC CTTTCCTTGG GGAAATGCCC GCAGAGCCCA TGACGATTGA TGAACTGTAT 
GAGCTGGTGG TGGATGCCAT CTTTGGCTTC AGCTTCAAGG GCGATGTTCG GGAACCGTTC 
CACAGCATCC TGAGTGTCCT GAAGGGACTC ACTGTGCCCA TTGCCAGCAT CGACATTCCC 
TCAGGTGCTG GGATCCAGAA GCTGGCTGGT GAGCAGAACA AGAAGAGGAA ATGCTCTGGT 
TCATCAGGTC TTCACAGTGG ACAAGTGCCA GTGACTGACA GTAAAGATGC CCCGCTCCAC 
CCCGACCATA GTACCTGTTC ACAGTACCTT CATTTAATCA GATTAATTGA GAGTCTACTA 
TGGGCCAAGG AGTTGGGGAT TCAGAGTGGA ATAAGAATGA GATGGGCCCA GCCCAGATGG 
AATCTACATA GGCAATTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NAXE ( NM_144772.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_658985.2 Homo sapiens NAD(P)HX epimerase (NAXE), mRNA.

Price & Availability↑

CloneID	OHu30002
Clone ID Related Accession (Same CDS sequence)	NM_144772.2 , NM_144772.3
Accession Version	NM_144772.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Homo sapiens(human)
Product	NAD(P)H-hydrate epimerase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ430064.1, BC100933.1, BG723681.1 and AL365181.24. This sequence is a reference standard in the RefSeqGene project. On Apr 13, 2006 this sequence version replaced NM_144772.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.169823.1, AK298222.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGGC TGCGGGCGCT GCTGGGCCTC GGGCTGCTGG TTGCGGGCTC GCGCGTGCCG 
CGGATCAAAA GCCAGACCAT CGCCTGTCGC TCGGGACCCA CCTGGTGGGG ACCGCAGCGG 
CTGAACTCGG GTGGCCGCTG GGACTCAGAG GTCATGGCGA GCACGGTGGT GAAGTACCTG 
AGCCAGGAGG AGGCCCAGGC CGTGGACCAG GAGCTATTTA ACGAATACCA GTTCAGCGTG 
GACCAACTTA TGGAACTGGC CGGGCTGAGC TGTGCTACAG CCATCGCCAA GGCATATCCC 
CCCACGTCCA TGTCCAGGAG CCCCCCTACT GTCCTGGTCA TCTGTGGCCC GGGGAATAAT 
GGAGGAGATG GTCTGGTCTG TGCTCGACAC CTCAAACTCT TTGGCTACGA GCCAACCATC 
TATTACCCCA AAAGGCCTAA CAAGCCCCTC TTCACTGCAT TGGTGACCCA GTGTCAGAAA 
ATGGACATCC CTTTCCTTGG GGAAATGCCC GCAGAGCCCA TGACGATTGA TGAACTGTAT 
GAGCTGGTGG TGGATGCCAT CTTTGGCTTC AGCTTCAAGG GCGATGTTCG GGAACCGTTC 
CACAGCATCC TGAGTGTCCT GAAGGGACTC ACTGTGCCCA TTGCCAGCAT CGACATTCCC 
TCAGGATGGG ACGTGGAGAA GGGAAATGCT GGAGGGATCC AGCCAGACTT GCTCATATCC 
CTCACAGCCC CCAAAAAATC TGCAACCCAG TTTACCGGTC GCTACCATTA CCTGGGGGGT 
CGTTTTGTGC CACCTGCTCT GGAGAAGAAG TACCAGCTGA ACCTGCCACC CTACCCTGAC 
ACCGAGTGTG TCTATCGTCT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_658985.2
CDS	40..906
Translation	MSRLRALLGLGLLVAGSRVPRIKSQTIACRSGPTWWGPQRLNSGGRWDSEVMASTVVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSRSPPTVLVICGPGNNGGDGLVCARHLKLFGYEPTIYYPKRPNKPLFTALVTQCQKMDIPFLGEMPAEPMTIDELYELVVDAIFGFSFKGDVREPFHSILSVLKGLTVPIASIDIPSGWDVEKGNAGGIQPDLLISLTAPKKSATQFTGRYHYLGGRFVPPALEKKYQLNLPPYPDTECVYRLQ

Target ORF information:

RefSeq Version	NM_144772.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NAD(P)HX epimerase (NAXE), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144772.2

ORF Insert Sequence:

ATGTCCAGGC TGCGGGCGCT GCTGGGCCTC GGGCTGCTGG TTGCGGGCTC GCGCGTGCCG 
CGGATCAAAA GCCAGACCAT CGCCTGTCGC TCGGGACCCA CCTGGTGGGG ACCGCAGCGG 
CTGAACTCGG GTGGCCGCTG GGACTCAGAG GTCATGGCGA GCACGGTGGT GAAGTACCTG 
AGCCAGGAGG AGGCCCAGGC CGTGGACCAG GAGCTATTTA ACGAATACCA GTTCAGCGTG 
GACCAACTTA TGGAACTGGC CGGGCTGAGC TGTGCTACAG CCATCGCCAA GGCATATCCC 
CCCACGTCCA TGTCCAGGAG CCCCCCTACT GTCCTGGTCA TCTGTGGCCC GGGGAATAAT 
GGAGGAGATG GTCTGGTCTG TGCTCGACAC CTCAAACTCT TTGGCTACGA GCCAACCATC 
TATTACCCCA AAAGGCCTAA CAAGCCCCTC TTCACTGCAT TGGTGACCCA GTGTCAGAAA 
ATGGACATCC CTTTCCTTGG GGAAATGCCC GCAGAGCCCA TGACGATTGA TGAACTGTAT 
GAGCTGGTGG TGGATGCCAT CTTTGGCTTC AGCTTCAAGG GCGATGTTCG GGAACCGTTC 
CACAGCATCC TGAGTGTCCT GAAGGGACTC ACTGTGCCCA TTGCCAGCAT CGACATTCCC 
TCAGGATGGG ACGTGGAGAA GGGAAATGCT GGAGGGATCC AGCCAGACTT GCTCATATCC 
CTCACAGCCC CCAAAAAATC TGCAACCCAG TTTACCGGTC GCTACCATTA CCTGGGGGGT 
CGTTTTGTGC CACCTGCTCT GGAGAAGAAG TACCAGCTGA ACCTGCCACC CTACCCTGAC 
ACCGAGTGTG TCTATCGTCT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NAXE ( NM_144772.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_658985.2 Homo sapiens NAD(P)HX epimerase (NAXE), mRNA.

Price & Availability↑

CloneID	OHu30002
Clone ID Related Accession (Same CDS sequence)	NM_144772.2 , NM_144772.3
Accession Version	NM_144772.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	NAD(P)H-hydrate epimerase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ430064.1, BC100933.1, BG723681.1 and AL365181.24. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_144772.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.179824.1, SRR1803615.231201.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368235.8/ ENSP00000357218.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCAGGC TGCGGGCGCT GCTGGGCCTC GGGCTGCTGG TTGCGGGCTC GCGCGTGCCG 
CGGATCAAAA GCCAGACCAT CGCCTGTCGC TCGGGACCCA CCTGGTGGGG ACCGCAGCGG 
CTGAACTCGG GTGGCCGCTG GGACTCAGAG GTCATGGCGA GCACGGTGGT GAAGTACCTG 
AGCCAGGAGG AGGCCCAGGC CGTGGACCAG GAGCTATTTA ACGAATACCA GTTCAGCGTG 
GACCAACTTA TGGAACTGGC CGGGCTGAGC TGTGCTACAG CCATCGCCAA GGCATATCCC 
CCCACGTCCA TGTCCAGGAG CCCCCCTACT GTCCTGGTCA TCTGTGGCCC GGGGAATAAT 
GGAGGAGATG GTCTGGTCTG TGCTCGACAC CTCAAACTCT TTGGCTACGA GCCAACCATC 
TATTACCCCA AAAGGCCTAA CAAGCCCCTC TTCACTGCAT TGGTGACCCA GTGTCAGAAA 
ATGGACATCC CTTTCCTTGG GGAAATGCCC GCAGAGCCCA TGACGATTGA TGAACTGTAT 
GAGCTGGTGG TGGATGCCAT CTTTGGCTTC AGCTTCAAGG GCGATGTTCG GGAACCGTTC 
CACAGCATCC TGAGTGTCCT GAAGGGACTC ACTGTGCCCA TTGCCAGCAT CGACATTCCC 
TCAGGATGGG ACGTGGAGAA GGGAAATGCT GGAGGGATCC AGCCAGACTT GCTCATATCC 
CTCACAGCCC CCAAAAAATC TGCAACCCAG TTTACCGGTC GCTACCATTA CCTGGGGGGT 
CGTTTTGTGC CACCTGCTCT GGAGAAGAAG TACCAGCTGA ACCTGCCACC CTACCCTGAC 
ACCGAGTGTG TCTATCGTCT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_658985.2
CDS	30..896
Translation	MSRLRALLGLGLLVAGSRVPRIKSQTIACRSGPTWWGPQRLNSGGRWDSEVMASTVVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSRSPPTVLVICGPGNNGGDGLVCARHLKLFGYEPTIYYPKRPNKPLFTALVTQCQKMDIPFLGEMPAEPMTIDELYELVVDAIFGFSFKGDVREPFHSILSVLKGLTVPIASIDIPSGWDVEKGNAGGIQPDLLISLTAPKKSATQFTGRYHYLGGRFVPPALEKKYQLNLPPYPDTECVYRLQ

Target ORF information:

RefSeq Version	NM_144772.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NAD(P)HX epimerase (NAXE), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144772.3

ORF Insert Sequence:

ATGTCCAGGC TGCGGGCGCT GCTGGGCCTC GGGCTGCTGG TTGCGGGCTC GCGCGTGCCG 
CGGATCAAAA GCCAGACCAT CGCCTGTCGC TCGGGACCCA CCTGGTGGGG ACCGCAGCGG 
CTGAACTCGG GTGGCCGCTG GGACTCAGAG GTCATGGCGA GCACGGTGGT GAAGTACCTG 
AGCCAGGAGG AGGCCCAGGC CGTGGACCAG GAGCTATTTA ACGAATACCA GTTCAGCGTG 
GACCAACTTA TGGAACTGGC CGGGCTGAGC TGTGCTACAG CCATCGCCAA GGCATATCCC 
CCCACGTCCA TGTCCAGGAG CCCCCCTACT GTCCTGGTCA TCTGTGGCCC GGGGAATAAT 
GGAGGAGATG GTCTGGTCTG TGCTCGACAC CTCAAACTCT TTGGCTACGA GCCAACCATC 
TATTACCCCA AAAGGCCTAA CAAGCCCCTC TTCACTGCAT TGGTGACCCA GTGTCAGAAA 
ATGGACATCC CTTTCCTTGG GGAAATGCCC GCAGAGCCCA TGACGATTGA TGAACTGTAT 
GAGCTGGTGG TGGATGCCAT CTTTGGCTTC AGCTTCAAGG GCGATGTTCG GGAACCGTTC 
CACAGCATCC TGAGTGTCCT GAAGGGACTC ACTGTGCCCA TTGCCAGCAT CGACATTCCC 
TCAGGATGGG ACGTGGAGAA GGGAAATGCT GGAGGGATCC AGCCAGACTT GCTCATATCC 
CTCACAGCCC CCAAAAAATC TGCAACCCAG TTTACCGGTC GCTACCATTA CCTGGGGGGT 
CGTTTTGTGC CACCTGCTCT GGAGAAGAAG TACCAGCTGA ACCTGCCACC CTACCCTGAC 
ACCGAGTGTG TCTATCGTCT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation.
JCI insight3(16)(2018 08)
Choi SH,Wallace AM,Schneider DA,Burg E,Kim J,Alekseeva E,Ubags ND,Cool CD,Fang L,Suratt BT,Miller YI

[Clinical and genetic features of early-onset progressive encephalopathy associated with NAXE gene mutations].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics20(7)524-258(2018 Jul)
Yu D,Zhao FM,Cai XT,Zhou H,Cheng Y

Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function.
Bioscience reports38(3)(2018 06)
Niehaus TD,Elbadawi-Sidhu M,Huang L,Prunetti L,Gregory JF 3rd,de Crécy-Lagard V,Fiehn O,Hanson AD

Apolipoprotein A-1 Binding Protein Inhibits Inflammatory Signaling Pathways by Binding to Apolipoprotein A-1 in THP-1 Macrophages.
Circulation journal : official journal of the Japanese Circulation Society82(5)1396-1404(2018 04)
Zhang M,Zhao GJ,Yin K,Xia XD,Gong D,Zhao ZW,Chen LY,Zheng XL,Tang XE,Tang CK

NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood.
American journal of human genetics99(4)894-902(2016 Oct)
Kremer LS,Danhauser K,Herebian D,Petkovic Ramadža D,Piekutowska-Abramczuk D,Seibt A,Müller-Felber W,Haack TB,Płoski R,Lohmeier K,Schneider D,Klee D,Rokicki D,Mayatepek E,Strom TM,Meitinger T,Klopstock T,Pronicka E,Mayr JA,Baric I,Distelmaier F,Prokisch H

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NAXE cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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