GJB4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GJB4
Entrez Gene ID	127534
Full Name	gap junction protein beta 4
Synonyms	CX30.3,EKV,EKVP2
General protein information	Preferred Names gap junction protein beta 4 Names gap junction beta-4 protein connexin 30.3 gap junction protein, beta 4, 30.3kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.3
Summary	This gene encodes a transmembrane connexin protein that is a component of gap junctions. Mutations in this gene have been associated with erythrokeratodermia variabilis, progressive symmetric erythrokeratoderma and hearing impairment. [provided by RefSeq, Dec 2009].
Disorder MIM:	605425
Disorder Html:	Erythrokeratodermia variabilis et progressiva 2, 617524 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011540679.1	XP_011538981.1	gap junction beta-4 protein isoform X1
NM_153212.2	NP_694944.1	gap junction beta-4 protein
NM_153212.3	NP_694944.1	gap junction beta-4 protein
XM_011540679.2	XP_011538981.1	gap junction beta-4 protein isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	GJB4	NP_694944.1
Macaca mulatta (Rhesus monkey)	GJB4	XP_001108592.1
Rattus norvegicus (Norway rat)	Gjb4	NP_446436.1
Pan troglodytes (chimpanzee)	GJB4	XP_003308016.1
Mus musculus (house mouse)	Gjb4	NP_032153.1
Bos taurus (cattle)	GJB4	NP_001178300.1
Canis lupus familiaris (dog)	GJB4	XP_005629033.1
Danio rerio (zebrafish)	cx34.4	NP_001124108.1
Xenopus tropicalis (tropical clawed frog)	LOC100486331	XP_004911666.1

Gene Ontology
Bibliography

Related articles in PubMed

Gjb4 serves as a novel biomarker for lung cancer and promotes metastasis and chemoresistance via Src activation.
Lin YP, Wu JI, Tseng CW, Chen HJ, Wang LH
Oncogene38(6)822-837(2019 02)

Association between mutations in the gap junction β4 gene and nonsyndromic hearing loss: genotype-phenotype correlation patterns.
Li TC, Wang WH, Li C, Yang JJ
Molecular medicine reports11(1)619-24(2015 Jan)

Progressive symmetrical erythrokeratoderma: report of two Chinese families and evaluation for mutations in the loricrin, connexin 30.3 and connexin 31 genes.
Guo BR, Sun LD, Cui Y, Yang S, Zhang XJ
Clinical and experimental dermatology38(8)925-7(2013 Dec)

Novel mutation in GJB4 gene (connexin 30.3) in a family with erythrokeratodermia variabilis.
Sbidian E, Bousseloua N, Jonard L, Leclerc-Mercier S, Bodemer C, Hadj-Rabia S
Acta dermato-venereologica93(2)193-5(2013 Mar)

Erythrokeratodermia variabilis: report of two cases and a novel missense variant in GJB4 encoding connexin 30.3.
Kokotas H, Papagiannaki K, Grigoriadou M, Petersen MB, Katsarou A
European journal of dermatology : EJD22(2)182-6(2012 Mar-Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GJB4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GJB4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22442	NM_153212.3 Latest version!	Homo sapiens gap junction protein beta 4 (GJB4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OHu22442	XM_011540679.2 Latest version!	Homo sapiens gap junction protein beta 4 (GJB4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
View Old Accession Versions >>
OHu22442	NM_153212.2	Homo sapiens gap junction protein beta 4 (GJB4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OHu22442	XM_011540679.1	Homo sapiens gap junction protein, beta 4, 30.3kDa (GJB4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GJB4 ( NM_153212.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_694944.1 Homo sapiens gap junction protein beta 4 (GJB4), mRNA.

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CloneID	OHu22442
Clone ID Related Accession (Same CDS sequence)	XM_011540679.1 , NM_153212.2 , NM_153212.3 , XM_011540679.2
Accession Version	NM_153212.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	gap junction beta-4 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK057628.1 and AL121988.10. This sequence is a reference standard in the RefSeqGene project. On Dec 15, 2009 this sequence version replaced NM_153212.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK057628.1, CV574426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACTGGG CATTTCTGCA GGGCCTGCTG AGTGGCGTGA ACAAGTACTC CACAGTGCTG 
AGCCGCATCT GGCTGTCTGT GGTGTTCATC TTTCGTGTGC TGGTGTACGT GGTGGCAGCG 
GAGGAGGTGT GGGACGATGA GCAGAAGGAC TTTGTCTGCA ACACCAAGCA GCCCGGCTGC 
CCCAACGTCT GCTATGACGA GTTCTTCCCC GTGTCCCACG TGCGCCTCTG GGCCCTACAG 
CTCATCCTGG TCACGTGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGCGAGGAA 
CGCGAGCGCA AGCACCACCT GAAACACGGG CCCAATGCCC CGTCCCTGTA CGACAACCTG 
AGCAAGAAGC GGGGCGGACT GTGGTGGACG TACTTGCTGA GCCTCATCTT CAAGGCCGCC 
GTGGATGCTG GCTTCCTCTA TATCTTCCAC CGCCTCTACA AGGATTATGA CATGCCCCGC 
GTGGTGGCCT GCTCCGTGGA GCCTTGCCCC CACACTGTGG ACTGTTACAT CTCCCGGCCC 
ACGGAGAAGA AGGTCTTCAC CTACTTCATG GTGACCACAG CTGCCATCTG CATCCTGCTC 
AACCTCAGTG AAGTCTTCTA CCTGGTGGGC AAGAGGTGCA TGGAGATCTT CGGCCCCAGG 
CACCGGCGGC CTCGGTGCCG GGAATGCCTA CCCGATACGT GCCCACCATA TGTCCTCTCC 
CAGGGAGGGC ACCCTGAGGA TGGGAACTCT GTCCTAATGA AGGCTGGGTC GGCCCCAGTG 
GATGCAGGTG GGTATCCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694944.1
CDS	371..1171
Translation	MNWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHHLKHGPNAPSLYDNLSKKRGGLWWTYLLSLIFKAAVDAGFLYIFHRLYKDYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVGKRCMEIFGPRHRRPRCRECLPDTCPPYVLSQGGHPEDGNSVLMKAGSAPVDAGGYP

Target ORF information:

RefSeq Version	NM_153212.2
Organism	Homo sapiens(human)
Definition	Homo sapiens gap junction protein beta 4 (GJB4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153212.2

ORF Insert Sequence:

ATGAACTGGG CATTTCTGCA GGGCCTGCTG AGTGGCGTGA ACAAGTACTC CACAGTGCTG 
AGCCGCATCT GGCTGTCTGT GGTGTTCATC TTTCGTGTGC TGGTGTACGT GGTGGCAGCG 
GAGGAGGTGT GGGACGATGA GCAGAAGGAC TTTGTCTGCA ACACCAAGCA GCCCGGCTGC 
CCCAACGTCT GCTATGACGA GTTCTTCCCC GTGTCCCACG TGCGCCTCTG GGCCCTACAG 
CTCATCCTGG TCACGTGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGCGAGGAA 
CGCGAGCGCA AGCACCACCT GAAACACGGG CCCAATGCCC CGTCCCTGTA CGACAACCTG 
AGCAAGAAGC GGGGCGGACT GTGGTGGACG TACTTGCTGA GCCTCATCTT CAAGGCCGCC 
GTGGATGCTG GCTTCCTCTA TATCTTCCAC CGCCTCTACA AGGATTATGA CATGCCCCGC 
GTGGTGGCCT GCTCCGTGGA GCCTTGCCCC CACACTGTGG ACTGTTACAT CTCCCGGCCC 
ACGGAGAAGA AGGTCTTCAC CTACTTCATG GTGACCACAG CTGCCATCTG CATCCTGCTC 
AACCTCAGTG AAGTCTTCTA CCTGGTGGGC AAGAGGTGCA TGGAGATCTT CGGCCCCAGG 
CACCGGCGGC CTCGGTGCCG GGAATGCCTA CCCGATACGT GCCCACCATA TGTCCTCTCC 
CAGGGAGGGC ACCCTGAGGA TGGGAACTCT GTCCTAATGA AGGCTGGGTC GGCCCCAGTG 
GATGCAGGTG GGTATCCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GJB4 ( NM_153212.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_694944.1 Homo sapiens gap junction protein beta 4 (GJB4), mRNA.

Price & Availability↑

CloneID	OHu22442
Clone ID Related Accession (Same CDS sequence)	XM_011540679.1 , NM_153212.2 , NM_153212.3 , XM_011540679.2
Accession Version	NM_153212.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569513600000
Organism	Homo sapiens(human)
Product	gap junction beta-4 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121988.10 and AK057628.1. This sequence is a reference standard in the RefSeqGene project. On Dec 12, 2018 this sequence version replaced NM_153212.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK057628.1, CV574426.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000339480.3/ ENSP00000345868.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAACTGGG CATTTCTGCA GGGCCTGCTG AGTGGCGTGA ACAAGTACTC CACAGTGCTG 
AGCCGCATCT GGCTGTCTGT GGTGTTCATC TTTCGTGTGC TGGTGTACGT GGTGGCAGCG 
GAGGAGGTGT GGGACGATGA GCAGAAGGAC TTTGTCTGCA ACACCAAGCA GCCCGGCTGC 
CCCAACGTCT GCTATGACGA GTTCTTCCCC GTGTCCCACG TGCGCCTCTG GGCCCTACAG 
CTCATCCTGG TCACGTGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGCGAGGAA 
CGCGAGCGCA AGCACCACCT GAAACACGGG CCCAATGCCC CGTCCCTGTA CGACAACCTG 
AGCAAGAAGC GGGGCGGACT GTGGTGGACG TACTTGCTGA GCCTCATCTT CAAGGCCGCC 
GTGGATGCTG GCTTCCTCTA TATCTTCCAC CGCCTCTACA AGGATTATGA CATGCCCCGC 
GTGGTGGCCT GCTCCGTGGA GCCTTGCCCC CACACTGTGG ACTGTTACAT CTCCCGGCCC 
ACGGAGAAGA AGGTCTTCAC CTACTTCATG GTGACCACAG CTGCCATCTG CATCCTGCTC 
AACCTCAGTG AAGTCTTCTA CCTGGTGGGC AAGAGGTGCA TGGAGATCTT CGGCCCCAGG 
CACCGGCGGC CTCGGTGCCG GGAATGCCTA CCCGATACGT GCCCACCATA TGTCCTCTCC 
CAGGGAGGGC ACCCTGAGGA TGGGAACTCT GTCCTAATGA AGGCTGGGTC GGCCCCAGTG 
GATGCAGGTG GGTATCCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694944.1
CDS	372..1172
Translation	MNWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHHLKHGPNAPSLYDNLSKKRGGLWWTYLLSLIFKAAVDAGFLYIFHRLYKDYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVGKRCMEIFGPRHRRPRCRECLPDTCPPYVLSQGGHPEDGNSVLMKAGSAPVDAGGYP

Target ORF information:

RefSeq Version	NM_153212.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gap junction protein beta 4 (GJB4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153212.3

ORF Insert Sequence:

ATGAACTGGG CATTTCTGCA GGGCCTGCTG AGTGGCGTGA ACAAGTACTC CACAGTGCTG 
AGCCGCATCT GGCTGTCTGT GGTGTTCATC TTTCGTGTGC TGGTGTACGT GGTGGCAGCG 
GAGGAGGTGT GGGACGATGA GCAGAAGGAC TTTGTCTGCA ACACCAAGCA GCCCGGCTGC 
CCCAACGTCT GCTATGACGA GTTCTTCCCC GTGTCCCACG TGCGCCTCTG GGCCCTACAG 
CTCATCCTGG TCACGTGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGCGAGGAA 
CGCGAGCGCA AGCACCACCT GAAACACGGG CCCAATGCCC CGTCCCTGTA CGACAACCTG 
AGCAAGAAGC GGGGCGGACT GTGGTGGACG TACTTGCTGA GCCTCATCTT CAAGGCCGCC 
GTGGATGCTG GCTTCCTCTA TATCTTCCAC CGCCTCTACA AGGATTATGA CATGCCCCGC 
GTGGTGGCCT GCTCCGTGGA GCCTTGCCCC CACACTGTGG ACTGTTACAT CTCCCGGCCC 
ACGGAGAAGA AGGTCTTCAC CTACTTCATG GTGACCACAG CTGCCATCTG CATCCTGCTC 
AACCTCAGTG AAGTCTTCTA CCTGGTGGGC AAGAGGTGCA TGGAGATCTT CGGCCCCAGG 
CACCGGCGGC CTCGGTGCCG GGAATGCCTA CCCGATACGT GCCCACCATA TGTCCTCTCC 
CAGGGAGGGC ACCCTGAGGA TGGGAACTCT GTCCTAATGA AGGCTGGGTC GGCCCCAGTG 
GATGCAGGTG GGTATCCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GJB4 ( XM_011540679.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538981.1 Homo sapiens gap junction protein, beta 4, 30.3kDa (GJB4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu22442
Clone ID Related Accession (Same CDS sequence)	XM_011540679.1 , NM_153212.2 , NM_153212.3 , XM_011540679.2
Accession Version	XM_011540679.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426003200000
Organism	Homo sapiens(Human)
Product	gap junction beta-4 protein isoform X1
Comment

ATGAACTGGG CATTTCTGCA GGGCCTGCTG AGTGGCGTGA ACAAGTACTC CACAGTGCTG 
AGCCGCATCT GGCTGTCTGT GGTGTTCATC TTTCGTGTGC TGGTGTACGT GGTGGCAGCG 
GAGGAGGTGT GGGACGATGA GCAGAAGGAC TTTGTCTGCA ACACCAAGCA GCCCGGCTGC 
CCCAACGTCT GCTATGACGA GTTCTTCCCC GTGTCCCACG TGCGCCTCTG GGCCCTACAG 
CTCATCCTGG TCACGTGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGCGAGGAA 
CGCGAGCGCA AGCACCACCT GAAACACGGG CCCAATGCCC CGTCCCTGTA CGACAACCTG 
AGCAAGAAGC GGGGCGGACT GTGGTGGACG TACTTGCTGA GCCTCATCTT CAAGGCCGCC 
GTGGATGCTG GCTTCCTCTA TATCTTCCAC CGCCTCTACA AGGATTATGA CATGCCCCGC 
GTGGTGGCCT GCTCCGTGGA GCCTTGCCCC CACACTGTGG ACTGTTACAT CTCCCGGCCC 
ACGGAGAAGA AGGTCTTCAC CTACTTCATG GTGACCACAG CTGCCATCTG CATCCTGCTC 
AACCTCAGTG AAGTCTTCTA CCTGGTGGGC AAGAGGTGCA TGGAGATCTT CGGCCCCAGG 
CACCGGCGGC CTCGGTGCCG GGAATGCCTA CCCGATACGT GCCCACCATA TGTCCTCTCC 
CAGGGAGGGC ACCCTGAGGA TGGGAACTCT GTCCTAATGA AGGCTGGGTC GGCCCCAGTG 
GATGCAGGTG GGTATCCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538981.1
Translation	MNWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHHLKHGPNAPSLYDNLSKKRGGLWWTYLLSLIFKAAVDAGFLYIFHRLYKDYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVGKRCMEIFGPRHRRPRCRECLPDTCPPYVLSQGGHPEDGNSVLMKAGSAPVDAGGYP

Target ORF information:

RefSeq Version	XM_011540679.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens gap junction protein, beta 4, 30.3kDa (GJB4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540679.1

ORF Insert Sequence:

ATGAACTGGG CATTTCTGCA GGGCCTGCTG AGTGGCGTGA ACAAGTACTC CACAGTGCTG 
AGCCGCATCT GGCTGTCTGT GGTGTTCATC TTTCGTGTGC TGGTGTACGT GGTGGCAGCG 
GAGGAGGTGT GGGACGATGA GCAGAAGGAC TTTGTCTGCA ACACCAAGCA GCCCGGCTGC 
CCCAACGTCT GCTATGACGA GTTCTTCCCC GTGTCCCACG TGCGCCTCTG GGCCCTACAG 
CTCATCCTGG TCACGTGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGCGAGGAA 
CGCGAGCGCA AGCACCACCT GAAACACGGG CCCAATGCCC CGTCCCTGTA CGACAACCTG 
AGCAAGAAGC GGGGCGGACT GTGGTGGACG TACTTGCTGA GCCTCATCTT CAAGGCCGCC 
GTGGATGCTG GCTTCCTCTA TATCTTCCAC CGCCTCTACA AGGATTATGA CATGCCCCGC 
GTGGTGGCCT GCTCCGTGGA GCCTTGCCCC CACACTGTGG ACTGTTACAT CTCCCGGCCC 
ACGGAGAAGA AGGTCTTCAC CTACTTCATG GTGACCACAG CTGCCATCTG CATCCTGCTC 
AACCTCAGTG AAGTCTTCTA CCTGGTGGGC AAGAGGTGCA TGGAGATCTT CGGCCCCAGG 
CACCGGCGGC CTCGGTGCCG GGAATGCCTA CCCGATACGT GCCCACCATA TGTCCTCTCC 
CAGGGAGGGC ACCCTGAGGA TGGGAACTCT GTCCTAATGA AGGCTGGGTC GGCCCCAGTG 
GATGCAGGTG GGTATCCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GJB4 ( XM_011540679.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538981.1 Homo sapiens gap junction protein beta 4 (GJB4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu22442
Clone ID Related Accession (Same CDS sequence)	XM_011540679.1 , NM_153212.2 , NM_153212.3 , XM_011540679.2
Accession Version	XM_011540679.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	gap junction beta-4 protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011540679.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACTGGG CATTTCTGCA GGGCCTGCTG AGTGGCGTGA ACAAGTACTC CACAGTGCTG 
AGCCGCATCT GGCTGTCTGT GGTGTTCATC TTTCGTGTGC TGGTGTACGT GGTGGCAGCG 
GAGGAGGTGT GGGACGATGA GCAGAAGGAC TTTGTCTGCA ACACCAAGCA GCCCGGCTGC 
CCCAACGTCT GCTATGACGA GTTCTTCCCC GTGTCCCACG TGCGCCTCTG GGCCCTACAG 
CTCATCCTGG TCACGTGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGCGAGGAA 
CGCGAGCGCA AGCACCACCT GAAACACGGG CCCAATGCCC CGTCCCTGTA CGACAACCTG 
AGCAAGAAGC GGGGCGGACT GTGGTGGACG TACTTGCTGA GCCTCATCTT CAAGGCCGCC 
GTGGATGCTG GCTTCCTCTA TATCTTCCAC CGCCTCTACA AGGATTATGA CATGCCCCGC 
GTGGTGGCCT GCTCCGTGGA GCCTTGCCCC CACACTGTGG ACTGTTACAT CTCCCGGCCC 
ACGGAGAAGA AGGTCTTCAC CTACTTCATG GTGACCACAG CTGCCATCTG CATCCTGCTC 
AACCTCAGTG AAGTCTTCTA CCTGGTGGGC AAGAGGTGCA TGGAGATCTT CGGCCCCAGG 
CACCGGCGGC CTCGGTGCCG GGAATGCCTA CCCGATACGT GCCCACCATA TGTCCTCTCC 
CAGGGAGGGC ACCCTGAGGA TGGGAACTCT GTCCTAATGA AGGCTGGGTC GGCCCCAGTG 
GATGCAGGTG GGTATCCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538981.1
CDS	659..1459
Translation	MNWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHHLKHGPNAPSLYDNLSKKRGGLWWTYLLSLIFKAAVDAGFLYIFHRLYKDYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVGKRCMEIFGPRHRRPRCRECLPDTCPPYVLSQGGHPEDGNSVLMKAGSAPVDAGGYP

Target ORF information:

RefSeq Version	XM_011540679.2
Organism	Homo sapiens(human)
Definition	Homo sapiens gap junction protein beta 4 (GJB4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540679.2

ORF Insert Sequence:

ATGAACTGGG CATTTCTGCA GGGCCTGCTG AGTGGCGTGA ACAAGTACTC CACAGTGCTG 
AGCCGCATCT GGCTGTCTGT GGTGTTCATC TTTCGTGTGC TGGTGTACGT GGTGGCAGCG 
GAGGAGGTGT GGGACGATGA GCAGAAGGAC TTTGTCTGCA ACACCAAGCA GCCCGGCTGC 
CCCAACGTCT GCTATGACGA GTTCTTCCCC GTGTCCCACG TGCGCCTCTG GGCCCTACAG 
CTCATCCTGG TCACGTGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGCGAGGAA 
CGCGAGCGCA AGCACCACCT GAAACACGGG CCCAATGCCC CGTCCCTGTA CGACAACCTG 
AGCAAGAAGC GGGGCGGACT GTGGTGGACG TACTTGCTGA GCCTCATCTT CAAGGCCGCC 
GTGGATGCTG GCTTCCTCTA TATCTTCCAC CGCCTCTACA AGGATTATGA CATGCCCCGC 
GTGGTGGCCT GCTCCGTGGA GCCTTGCCCC CACACTGTGG ACTGTTACAT CTCCCGGCCC 
ACGGAGAAGA AGGTCTTCAC CTACTTCATG GTGACCACAG CTGCCATCTG CATCCTGCTC 
AACCTCAGTG AAGTCTTCTA CCTGGTGGGC AAGAGGTGCA TGGAGATCTT CGGCCCCAGG 
CACCGGCGGC CTCGGTGCCG GGAATGCCTA CCCGATACGT GCCCACCATA TGTCCTCTCC 
CAGGGAGGGC ACCCTGAGGA TGGGAACTCT GTCCTAATGA AGGCTGGGTC GGCCCCAGTG 
GATGCAGGTG GGTATCCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gjb4 serves as a novel biomarker for lung cancer and promotes metastasis and chemoresistance via Src activation.
Oncogene38(6)822-837(2019 02)
Lin YP,Wu JI,Tseng CW,Chen HJ,Wang LH

Association between mutations in the gap junction β4 gene and nonsyndromic hearing loss: genotype-phenotype correlation patterns.
Molecular medicine reports11(1)619-24(2015 Jan)
Li TC,Wang WH,Li C,Yang JJ

Progressive symmetrical erythrokeratoderma: report of two Chinese families and evaluation for mutations in the loricrin, connexin 30.3 and connexin 31 genes.
Clinical and experimental dermatology38(8)925-7(2013 Dec)
Guo BR,Sun LD,Cui Y,Yang S,Zhang XJ

Novel mutation in GJB4 gene (connexin 30.3) in a family with erythrokeratodermia variabilis.
Acta dermato-venereologica93(2)193-5(2013 Mar)
Sbidian E,Bousseloua N,Jonard L,Leclerc-Mercier S,Bodemer C,Hadj-Rabia S

Erythrokeratodermia variabilis: report of two cases and a novel missense variant in GJB4 encoding connexin 30.3.
European journal of dermatology : EJD22(2)182-6(2012 Mar-Apr)
Kokotas H,Papagiannaki K,Grigoriadou M,Petersen MB,Katsarou A

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GJB4 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

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ORF Insert Sequence:

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ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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