| Gene Symbol | CNTF |
| Entrez Gene ID | 1270 |
| Full Name | ciliary neurotrophic factor |
| Synonyms | HCNTF |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]. |
| Disorder MIM: |
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CNTF cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following CNTF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CNTF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu26060 Clone ID Related Accession (Same CDS sequence) NM_000614.3 , NM_000614.4 Accession Version NM_000614.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 603bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1513440000000 Organism Homo sapiens(human) Product ciliary neurotrophic factor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB241497.1, BC068030.1 and DB341875.1. This sequence is a reference standard in the RefSeqGene project. On Oct 17, 2008 this sequence version replaced NM_000614.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC068030.1, SRR1660807.25441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601ATGGCTTTCA CAGAGCATTC ACCGCTGACC CCTCACCGTC GGGACCTCTG TAGCCGCTCT
ATCTGGCTAG CAAGGAAGAT TCGTTCAGAC CTGACTGCTC TTACGGAATC CTATGTGAAG
CATCAGGGCC TGAACAAGAA CATCAACCTG GACTCTGCGG ATGGGATGCC AGTGGCAAGC
ACTGATCAGT GGAGTGAGCT GACCGAGGCA GAGCGACTCC AAGAGAACCT TCAAGCTTAT
CGTACCTTCC ATGTTTTGTT GGCCAGGCTC TTAGAAGACC AGCAGGTGCA TTTTACCCCA
ACCGAAGGTG ACTTCCATCA AGCTATACAT ACCCTTCTTC TCCAAGTCGC TGCCTTTGCA
TACCAGATAG AGGAGTTAAT GATACTCCTG GAATACAAGA TCCCCCGCAA TGAGGCTGAT
GGGATGCCTA TTAATGTTGG AGATGGTGGT CTCTTTGAGA AGAAGCTGTG GGGCCTAAAG
GTGCTGCAGG AGCTTTCACA GTGGACAGTA AGGTCCATCC ATGACCTTCG TTTCATTTCT
TCTCATCAGA CTGGGATCCC AGCACGTGGG AGCCATTATA TTGCTAACAA CAAGAAAATG
TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_000605.1 CDS 81..683 Translation 
Target ORF information:
RefSeq Version NM_000614.3 Organism Homo sapiens(human) Definition Homo sapiens ciliary neurotrophic factor (CNTF), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_000614.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGGCTTTCA CAGAGCATTC ACCGCTGACC CCTCACCGTC GGGACCTCTG TAGCCGCTCT
ATCTGGCTAG CAAGGAAGAT TCGTTCAGAC CTGACTGCTC TTACGGAATC CTATGTGAAG
CATCAGGGCC TGAACAAGAA CATCAACCTG GACTCTGCGG ATGGGATGCC AGTGGCAAGC
ACTGATCAGT GGAGTGAGCT GACCGAGGCA GAGCGACTCC AAGAGAACCT TCAAGCTTAT
CGTACCTTCC ATGTTTTGTT GGCCAGGCTC TTAGAAGACC AGCAGGTGCA TTTTACCCCA
ACCGAAGGTG ACTTCCATCA AGCTATACAT ACCCTTCTTC TCCAAGTCGC TGCCTTTGCA
TACCAGATAG AGGAGTTAAT GATACTCCTG GAATACAAGA TCCCCCGCAA TGAGGCTGAT
GGGATGCCTA TTAATGTTGG AGATGGTGGT CTCTTTGAGA AGAAGCTGTG GGGCCTAAAG
GTGCTGCAGG AGCTTTCACA GTGGACAGTA AGGTCCATCC ATGACCTTCG TTTCATTTCT
TCTCATCAGA CTGGGATCCC AGCACGTGGG AGCCATTATA TTGCTAACAA CAAGAAAATG
TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu26060 Clone ID Related Accession (Same CDS sequence) NM_000614.3 , NM_000614.4 Accession Version NM_000614.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 603bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570377600000 Organism Homo sapiens(human) Product ciliary neurotrophic factor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001350.4, DB241497.1, BC068030.1 and DB341875.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000614.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC068030.1, SRR1660807.25441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361987.6/ ENSP00000355370.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601ATGGCTTTCA CAGAGCATTC ACCGCTGACC CCTCACCGTC GGGACCTCTG TAGCCGCTCT
ATCTGGCTAG CAAGGAAGAT TCGTTCAGAC CTGACTGCTC TTACGGAATC CTATGTGAAG
CATCAGGGCC TGAACAAGAA CATCAACCTG GACTCTGCGG ATGGGATGCC AGTGGCAAGC
ACTGATCAGT GGAGTGAGCT GACCGAGGCA GAGCGACTCC AAGAGAACCT TCAAGCTTAT
CGTACCTTCC ATGTTTTGTT GGCCAGGCTC TTAGAAGACC AGCAGGTGCA TTTTACCCCA
ACCGAAGGTG ACTTCCATCA AGCTATACAT ACCCTTCTTC TCCAAGTCGC TGCCTTTGCA
TACCAGATAG AGGAGTTAAT GATACTCCTG GAATACAAGA TCCCCCGCAA TGAGGCTGAT
GGGATGCCTA TTAATGTTGG AGATGGTGGT CTCTTTGAGA AGAAGCTGTG GGGCCTAAAG
GTGCTGCAGG AGCTTTCACA GTGGACAGTA AGGTCCATCC ATGACCTTCG TTTCATTTCT
TCTCATCAGA CTGGGATCCC AGCACGTGGG AGCCATTATA TTGCTAACAA CAAGAAAATG
TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_000605.1 CDS 89..691 Translation
Target ORF information:
RefSeq Version NM_000614.4 Organism Homo sapiens(human) Definition Homo sapiens ciliary neurotrophic factor (CNTF), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_000614.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGGCTTTCA CAGAGCATTC ACCGCTGACC CCTCACCGTC GGGACCTCTG TAGCCGCTCT
ATCTGGCTAG CAAGGAAGAT TCGTTCAGAC CTGACTGCTC TTACGGAATC CTATGTGAAG
CATCAGGGCC TGAACAAGAA CATCAACCTG GACTCTGCGG ATGGGATGCC AGTGGCAAGC
ACTGATCAGT GGAGTGAGCT GACCGAGGCA GAGCGACTCC AAGAGAACCT TCAAGCTTAT
CGTACCTTCC ATGTTTTGTT GGCCAGGCTC TTAGAAGACC AGCAGGTGCA TTTTACCCCA
ACCGAAGGTG ACTTCCATCA AGCTATACAT ACCCTTCTTC TCCAAGTCGC TGCCTTTGCA
TACCAGATAG AGGAGTTAAT GATACTCCTG GAATACAAGA TCCCCCGCAA TGAGGCTGAT
GGGATGCCTA TTAATGTTGG AGATGGTGGT CTCTTTGAGA AGAAGCTGTG GGGCCTAAAG
GTGCTGCAGG AGCTTTCACA GTGGACAGTA AGGTCCATCC ATGACCTTCG TTTCATTTCT
TCTCATCAGA CTGGGATCCC AGCACGTGGG AGCCATTATA TTGCTAACAA CAAGAAAATG
TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.
The EMBO journal37(21)(2018 11)
Alpár A,Zahola P,Hanics J,Hevesi Z,Korchynska S,Benevento M,Pifl C,Zachar G,Perugini J,Severi I,Leitgeb P,Bakker J,Miklosi AG,Tretiakov E,Keimpema E,Arque G,Tasan RO,Sperk G,Malenczyk K,Máté Z,Erdélyi F,Szabó G,Lubec G,Palkovits M,Giordano A,Hökfelt TG,Romanov RA,Horvath TL,Harkany T
Over-expression of CNTF in bone marrow mesenchymal stem cells protects RPE cells from short-wavelength, blue-light injury.
In vitro cellular & developmental biology. Animal54(5)355-365(2018 May)
Lin W,Xu G
Hypomethylation of CNTFRα is associated with proliferation and poor prognosis in lower grade gliomas.
Scientific reports7(1)7079(2017 08)
Fan K,Wang X,Zhang J,Ramos RI,Zhang H,Li C,Ye D,Kang J,Marzese DM,Hoon DSB,Hua W
High hydrostatic pressure enables almost 100% refolding of recombinant human ciliary neurotrophic factor from inclusion bodies at high concentration.
Protein expression and purification133152-159(2017 05)
Wang Q,Liu Y,Zhang C,Guo F,Feng C,Li X,Shi H,Su Z
Cytokines of the LIF/CNTF family and metabolism.
Cytokine82122-4(2016 06)
Pasquin S,Sharma M,Gauchat JF
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