JSRP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	JSRP1
Entrez Gene ID	126306
Full Name	junctional sarcoplasmic reticulum protein 1
Synonyms	JP-45,JP45
General protein information	Preferred Names junctional sarcoplasmic reticulum protein 1 Names junctional sarcoplasmic reticulum protein 1 2310032K21Rik homolog of mouse skeletal muscle sarcoplasmic reticulum protein JP-45 junctional-face membrane protein of 45 kDa homolog skeletal muscle sarcoplasmic reticulum protein JP-45
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	The protein encoded by this gene is involved in excitation-contraction coupling at the sarcoplasmic reticulum. The encoded protein can interact with CACNA1S, CACNB1, and calsequestrin to help regulate calcium influx and efflux in skeletal muscle. [provided by RefSeq, Jul 2012].
Disorder MIM:	608743

mRNA and Protein(s)

mRNA	Protein	Name
NM_144616.4	NP_653217.1	junctional sarcoplasmic reticulum protein 1
XM_017026285.1	XP_016881774.1	junctional sarcoplasmic reticulum protein 1 isoform X1
XM_017026286.1	XP_016881775.1	junctional sarcoplasmic reticulum protein 1 isoform X2
NM_144616.3	NP_653217.1	junctional sarcoplasmic reticulum protein 1
XM_017026287.1	XP_016881776.1	junctional sarcoplasmic reticulum protein 1 isoform X3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	JSRP1	NP_001039496.1
Mus musculus (house mouse)	Jsrp1	NP_082277.2
Rattus norvegicus (Norway rat)	Jsrp1	NP_001103061.1
Pan troglodytes (chimpanzee)	JSRP1	XP_003954515.1
Macaca mulatta (Rhesus monkey)	LOC100425172	XP_002801059.1
Homo sapiens (human)	JSRP1	NP_653217.1

Gene Ontology
Bibliography

Related articles in PubMed

JP-45/JSRP1 variants affect skeletal muscle excitation-contraction coupling by decreasing the sensitivity of the dihydropyridine receptor.
Yasuda T, Delbono O, Wang ZM, Messi ML, Girard T, Urwyler A, Treves S, Zorzato F
Human mutation34(1)184-90(2013 Jan)

Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study.
Newby PR, Pickles OJ, Mazumdar S, Brand OJ, Carr-Smith JD, Pearce SH, Franklyn JA, , Evans DM, Simmonds MJ, Gough SC
European journal of human genetics : EJHG18(9)1021-6(2010 Sep)

A possible role of the junctional face protein JP-45 in modulating Ca2+ release in skeletal muscle.
Gouadon E, Schuhmeier RP, Ursu D, Anderson AA, Treves S, Zorzato F, Lehmann-Horn F, Melzer W
The Journal of physiology572(Pt 1)269-80(2006 Apr)

The novel skeletal muscle sarcoplasmic reticulum JP-45 protein. Molecular cloning, tissue distribution, developmental expression, and interaction with alpha 1.1 subunit of the voltage-gated calcium channel.
Anderson AA, Treves S, Biral D, Betto R, Sandonà D, Ronjat M, Zorzato F
The Journal of biological chemistry278(41)39987-92(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following JSRP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the JSRP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu88206	XM_017026285.1 Latest version!	Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu88207	XM_017026286.1 Latest version!	Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu88208	XM_017026287.1 Latest version!	Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu17911	NM_144616.4 Latest version!	Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
View Old Accession Versions >>
OHu17911	NM_144616.3	Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

JSRP1 ( XM_017026285.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881774.1 Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88206
Clone ID Related Accession (Same CDS sequence)	XM_017026285.1
Accession Version	XM_017026285.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	junctional sarcoplasmic reticulum protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGTTCA CACCCACTAG GCTGGCAATA AAAACACAAA CAAAGAAACT GGAAAATGAC 
GAGTTGGACG TGGAGAAGTT GGAACGCTCC TGTATGGCTG CTGGGCAGCC TGGCCTGGGA 
CCTGCTGCTG CTCCAGCCAT GTCCATGACA ACCAGAGCCT GGGAGGAGCT GGATGGCGGC 
CTGGGCAGCT GCCAGGCCCT GGAGGACCAC TCTGCGCTGG CCGAGACCCA GGAGGACAGG 
GCTTCAGCGA CACCCAGGCT GGCCGACTCC GGCAGCGTGC CCCACGACTC TCAGGTGGCT 
GAAGGCCCCA GTGTGGACAC CAGGCCCAAG AAGATGGAAA AAGAGCCTGC CGCCAGGGGG 
ACCCCAGGAA CGGGGAAGGA GAGGCTGAAA GCCGGAGCGA GCCCTCGGAG CGTCCCCGCG 
CGCAAGAAGG CGCAGACCGC GCCGCCCCTG CAGCCGCCGC CGCCGCCCCC GGCCCTGAGC 
GAGGAGCTGC CCTGGGGAGA CCTGTCGCTC AACAAGTGCC TGGTGCTCGC CTCGCTGGTG 
GCGCTGCTGG GCTCGGCTTT CCAGCTGTGC CGCGGTGAGC GCAGGCTCCC CAGAGACGCC 
GTCCCTGGGG AGGCAGCACT CCAAGCACGT GTGCCCGAGC CCTGGGTCCC GCCAAGCTCA 
GCCCCGAGGG AGCCATCGTC GCCCCTGCCT AAGTTCGAGG CCCAGGCGCC TCCATCAGCG 
CCGCCTGCGC CCCGGGCCGA GGCAGAGGTC AGACCCAAGA TTCCCGGGAG TCGGGAGGCT 
GCAGAGAACG ACGAAGAGGA GCCCGGCGAG GCCACCGGAG AGGCCGTCCG GGAGGACCGT 
GTGACCCTCG CAGACCGGGG ACCCAAGGAG AGGCCTCGGA GAGAGGGGAA GCCGCGGAAG 
GAGAAGCCGC GGAAGGAGGA GAGACCTAAG AAAGAGAGGC CGCGGAAAGA GGAGAGGCCA 
CGGGCCGCCA GGGAGCCCCG GGAAGCCCTA CCCCAGCGCT GGGAGTCACG CGAAGGGGGC 
CACCGGCCGT GGGCACGGGA CTCCAGGGAC GCCGAGCCCA GGAAGAAGCA GGCCTGGGTG 
TCCCCGAGGC GTCCCGACGA GGAGCAGCGG CCTGGGAGTC GCCAGAAGCT CCGCGCAGGC 
AAGGGGCGGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881774.1
CDS	328..1482
Translation	MPFTPTRLAIKTQTKKLENDELDVEKLERSCMAAGQPGLGPAAAPAMSMTTRAWEELDGGLGSCQALEDHSALAETQEDRASATPRLADSGSVPHDSQVAEGPSVDTRPKKMEKEPAARGTPGTGKERLKAGASPRSVPARKKAQTAPPLQPPPPPPALSEELPWGDLSLNKCLVLASLVALLGSAFQLCRGERRLPRDAVPGEAALQARVPEPWVPPSSAPREPSSPLPKFEAQAPPSAPPAPRAEAEVRPKIPGSREAAENDEEEPGEATGEAVREDRVTLADRGPKERPRREGKPRKEKPRKEERPKKERPRKEERPRAAREPREALPQRWESREGGHRPWARDSRDAEPRKKQAWVSPRRPDEEQRPGSRQKLRAGKGRD

Target ORF information:

RefSeq Version	XM_017026285.1
Organism	Homo sapiens(human)
Definition	Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026285.1

ORF Insert Sequence:

ATGCCGTTCA CACCCACTAG GCTGGCAATA AAAACACAAA CAAAGAAACT GGAAAATGAC 
GAGTTGGACG TGGAGAAGTT GGAACGCTCC TGTATGGCTG CTGGGCAGCC TGGCCTGGGA 
CCTGCTGCTG CTCCAGCCAT GTCCATGACA ACCAGAGCCT GGGAGGAGCT GGATGGCGGC 
CTGGGCAGCT GCCAGGCCCT GGAGGACCAC TCTGCGCTGG CCGAGACCCA GGAGGACAGG 
GCTTCAGCGA CACCCAGGCT GGCCGACTCC GGCAGCGTGC CCCACGACTC TCAGGTGGCT 
GAAGGCCCCA GTGTGGACAC CAGGCCCAAG AAGATGGAAA AAGAGCCTGC CGCCAGGGGG 
ACCCCAGGAA CGGGGAAGGA GAGGCTGAAA GCCGGAGCGA GCCCTCGGAG CGTCCCCGCG 
CGCAAGAAGG CGCAGACCGC GCCGCCCCTG CAGCCGCCGC CGCCGCCCCC GGCCCTGAGC 
GAGGAGCTGC CCTGGGGAGA CCTGTCGCTC AACAAGTGCC TGGTGCTCGC CTCGCTGGTG 
GCGCTGCTGG GCTCGGCTTT CCAGCTGTGC CGCGGTGAGC GCAGGCTCCC CAGAGACGCC 
GTCCCTGGGG AGGCAGCACT CCAAGCACGT GTGCCCGAGC CCTGGGTCCC GCCAAGCTCA 
GCCCCGAGGG AGCCATCGTC GCCCCTGCCT AAGTTCGAGG CCCAGGCGCC TCCATCAGCG 
CCGCCTGCGC CCCGGGCCGA GGCAGAGGTC AGACCCAAGA TTCCCGGGAG TCGGGAGGCT 
GCAGAGAACG ACGAAGAGGA GCCCGGCGAG GCCACCGGAG AGGCCGTCCG GGAGGACCGT 
GTGACCCTCG CAGACCGGGG ACCCAAGGAG AGGCCTCGGA GAGAGGGGAA GCCGCGGAAG 
GAGAAGCCGC GGAAGGAGGA GAGACCTAAG AAAGAGAGGC CGCGGAAAGA GGAGAGGCCA 
CGGGCCGCCA GGGAGCCCCG GGAAGCCCTA CCCCAGCGCT GGGAGTCACG CGAAGGGGGC 
CACCGGCCGT GGGCACGGGA CTCCAGGGAC GCCGAGCCCA GGAAGAAGCA GGCCTGGGTG 
TCCCCGAGGC GTCCCGACGA GGAGCAGCGG CCTGGGAGTC GCCAGAAGCT CCGCGCAGGC 
AAGGGGCGGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JSRP1 ( XM_017026286.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881775.1 Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu88207
Clone ID Related Accession (Same CDS sequence)	XM_017026286.1
Accession Version	XM_017026286.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	junctional sarcoplasmic reticulum protein 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGTTCA CACCCACTAG GCTGGCAATA AAAACACAAA CAAAGAAACT GGAAAATGAC 
GAGTTGGACG TGGAGAAGTT GGAACGCTCC TGTATGGCTG CTGGGCAGCC TGGCCTGGGA 
CCTGCTGCTG CTCCAGCCAT GTCCATGACA ACCAGAGCCT GGGAGGAGCT GGATGGCGGC 
CTGGGCAGCT GCCAGGCCCT GGAGGACCAC TCTGCGCTGG CCGAGACCCA GGAGGACAGG 
GCTTCAGCGA CACCCAGGCT GGCCGACTCC GGCAGCGTGC CCCACGACTC TCAGGTGGCT 
GAAGGCCCCA GTGTGGACAC CAGGCCCAAG AAGATGGAAA AAGAGCCTGC CGCCAGGGGG 
ACCCCAGGAA CGGGGAAGGA GAGGCTGAAA GCCGGAGCGA GCCCTCGGAG CGTCCCCGCG 
CGCAAGAAGG CGCAGACCGC GCCGCCCCTG CAGCCGCCGC CGCCGCCCCC GGCCCTGAGC 
GAGGAGCTGC CCTGGGGAGA CCTGTCGCTC AACAAGTGCC TGGTGCTCGC CTCGCTGGTG 
GCGCTGCTGG GCTCGGCTTT CCAGCTGTGC CGCGACGCCG TCCCTGGGGA GGCAGCACTC 
CAAGCACGTG TGCCCGAGCC CTGGGTCCCG CCAAGCTCAG CCCCGAGGGA GCCATCGTCG 
CCCCTGCCTA AGTTCGAGGC CCAGGCGCCT CCATCAGCGC CGCCTGCGCC CCGGGCCGAG 
GCAGAGGTCA GACCCAAGAT TCCCGGGAGT CGGGAGGCTG CAGAGAACGA CGAAGAGGAG 
CCCGGCGAGG CCACCGGAGA GGCCGTCCGG GAGGACCGTG TGACCCTCGC AGACCGGGGA 
CCCAAGGAGA GGCCTCGGAG AGAGGGGAAG CCGCGGAAGG AGAAGCCGCG GAAGGAGGAG 
AGACCTAAGA AAGAGAGGCC GCGGAAAGAG GAGAGGCCAC GGGCCGCCAG GGAGCCCCGG 
GAAGCCCTAC CCCAGCGCTG GGAGTCACGC GAAGGGGGCC ACCGGCCGTG GGCACGGGAC 
TCCAGGGACG CCGAGCCCAG GAAGAAGCAG GCCTGGGTGT CCCCGAGGCG TCCCGACGAG 
GAGCAGCGGC CTGGGAGTCG CCAGAAGCTC CGCGCAGGCA AGGGGCGGGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881775.1
CDS	328..1461
Translation	MPFTPTRLAIKTQTKKLENDELDVEKLERSCMAAGQPGLGPAAAPAMSMTTRAWEELDGGLGSCQALEDHSALAETQEDRASATPRLADSGSVPHDSQVAEGPSVDTRPKKMEKEPAARGTPGTGKERLKAGASPRSVPARKKAQTAPPLQPPPPPPALSEELPWGDLSLNKCLVLASLVALLGSAFQLCRDAVPGEAALQARVPEPWVPPSSAPREPSSPLPKFEAQAPPSAPPAPRAEAEVRPKIPGSREAAENDEEEPGEATGEAVREDRVTLADRGPKERPRREGKPRKEKPRKEERPKKERPRKEERPRAAREPREALPQRWESREGGHRPWARDSRDAEPRKKQAWVSPRRPDEEQRPGSRQKLRAGKGRD

Target ORF information:

RefSeq Version	XM_017026286.1
Organism	Homo sapiens(human)
Definition	Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026286.1

ORF Insert Sequence:

ATGCCGTTCA CACCCACTAG GCTGGCAATA AAAACACAAA CAAAGAAACT GGAAAATGAC 
GAGTTGGACG TGGAGAAGTT GGAACGCTCC TGTATGGCTG CTGGGCAGCC TGGCCTGGGA 
CCTGCTGCTG CTCCAGCCAT GTCCATGACA ACCAGAGCCT GGGAGGAGCT GGATGGCGGC 
CTGGGCAGCT GCCAGGCCCT GGAGGACCAC TCTGCGCTGG CCGAGACCCA GGAGGACAGG 
GCTTCAGCGA CACCCAGGCT GGCCGACTCC GGCAGCGTGC CCCACGACTC TCAGGTGGCT 
GAAGGCCCCA GTGTGGACAC CAGGCCCAAG AAGATGGAAA AAGAGCCTGC CGCCAGGGGG 
ACCCCAGGAA CGGGGAAGGA GAGGCTGAAA GCCGGAGCGA GCCCTCGGAG CGTCCCCGCG 
CGCAAGAAGG CGCAGACCGC GCCGCCCCTG CAGCCGCCGC CGCCGCCCCC GGCCCTGAGC 
GAGGAGCTGC CCTGGGGAGA CCTGTCGCTC AACAAGTGCC TGGTGCTCGC CTCGCTGGTG 
GCGCTGCTGG GCTCGGCTTT CCAGCTGTGC CGCGACGCCG TCCCTGGGGA GGCAGCACTC 
CAAGCACGTG TGCCCGAGCC CTGGGTCCCG CCAAGCTCAG CCCCGAGGGA GCCATCGTCG 
CCCCTGCCTA AGTTCGAGGC CCAGGCGCCT CCATCAGCGC CGCCTGCGCC CCGGGCCGAG 
GCAGAGGTCA GACCCAAGAT TCCCGGGAGT CGGGAGGCTG CAGAGAACGA CGAAGAGGAG 
CCCGGCGAGG CCACCGGAGA GGCCGTCCGG GAGGACCGTG TGACCCTCGC AGACCGGGGA 
CCCAAGGAGA GGCCTCGGAG AGAGGGGAAG CCGCGGAAGG AGAAGCCGCG GAAGGAGGAG 
AGACCTAAGA AAGAGAGGCC GCGGAAAGAG GAGAGGCCAC GGGCCGCCAG GGAGCCCCGG 
GAAGCCCTAC CCCAGCGCTG GGAGTCACGC GAAGGGGGCC ACCGGCCGTG GGCACGGGAC 
TCCAGGGACG CCGAGCCCAG GAAGAAGCAG GCCTGGGTGT CCCCGAGGCG TCCCGACGAG 
GAGCAGCGGC CTGGGAGTCG CCAGAAGCTC CGCGCAGGCA AGGGGCGGGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JSRP1 ( XM_017026287.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881776.1 Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu88208
Clone ID Related Accession (Same CDS sequence)	XM_017026287.1
Accession Version	XM_017026287.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	junctional sarcoplasmic reticulum protein 1 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCATGA CAACCAGAGC CTGGGAGGAG CTGGATGGCG GCCTGGGCAG CTGCCAGGCC 
CTGGAGGACC ACTCTGCGCT GGCCGAGACC CAGGAGGACA GGGCTTCAGC GACACCCAGG 
CTGGCCGACT CCGGCAGCGT GCCCCACGAC TCTCAGGTGG CTGAAGGCCC CAGTGTGGAC 
ACCAGGCCCA AGAAGATGGA AAAAGAGCCT GCCGCCAGGG GGACCCCAGG AACGGGGAAG 
GAGAGGCTGA AAGCCGGAGC GAGCCCTCGG AGCGTCCCCG CGCGCAAGAA GGCGCAGACC 
GCGCCGCCCC TGCAGCCGCC GCCGCCGCCC CCGGCCCTGA GCGAGGAGCT GCCCTGGGGA 
GACCTGTCGC TCAACAAGTG CCTGGTGCTC GCCTCGCTGG TGGCGCTGCT GGGCTCGGCT 
TTCCAGCTGT GCCGCGGTGA GCGCAGGCTC CCCAGAGACG CCGTCCCTGG GGAGGCAGCA 
CTCCAAGCAC GTGTGCCCGA GCCCTGGGTC CCGCCAAGCT CAGCCCCGAG GGAGCCATCG 
TCGCCCCTGC CTAAGTTCGA GGCCCAGGCG CCTCCATCAG CGCCGCCTGC GCCCCGGGCC 
GAGGCAGAGG TCAGACCCAA GATTCCCGGG AGTCGGGAGG CTGCAGAGAA CGACGAAGAG 
GAGCCCGGCG AGGCCACCGG AGAGGCCGTC CGGGAGGACC GTGTGACCCT CGCAGACCGG 
GGACCCAAGG AGAGGCCTCG GAGAGAGGGG AAGCCGCGGA AGGAGAAGCC GCGGAAGGAG 
GAGAGACCTA AGAAAGAGAG GCCGCGGAAA GAGGAGAGGC CACGGGCCGC CAGGGAGCCC 
CGGGAAGCCC TACCCCAGCG CTGGGAGTCA CGCGAAGGGG GCCACCGGCC GTGGGCACGG 
GACTCCAGGG ACGCCGAGCC CAGGAAGAAG CAGGCCTGGG TGTCCCCGAG GCGTCCCGAC 
GAGGAGCAGC GGCCTGGGAG TCGCCAGAAG CTCCGCGCAG GCAAGGGGCG GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881776.1
CDS	48..1064
Translation	MSMTTRAWEELDGGLGSCQALEDHSALAETQEDRASATPRLADSGSVPHDSQVAEGPSVDTRPKKMEKEPAARGTPGTGKERLKAGASPRSVPARKKAQTAPPLQPPPPPPALSEELPWGDLSLNKCLVLASLVALLGSAFQLCRGERRLPRDAVPGEAALQARVPEPWVPPSSAPREPSSPLPKFEAQAPPSAPPAPRAEAEVRPKIPGSREAAENDEEEPGEATGEAVREDRVTLADRGPKERPRREGKPRKEKPRKEERPKKERPRKEERPRAAREPREALPQRWESREGGHRPWARDSRDAEPRKKQAWVSPRRPDEEQRPGSRQKLRAGKGRD

Target ORF information:

RefSeq Version	XM_017026287.1
Organism	Homo sapiens(human)
Definition	Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026287.1

ORF Insert Sequence:

ATGTCCATGA CAACCAGAGC CTGGGAGGAG CTGGATGGCG GCCTGGGCAG CTGCCAGGCC 
CTGGAGGACC ACTCTGCGCT GGCCGAGACC CAGGAGGACA GGGCTTCAGC GACACCCAGG 
CTGGCCGACT CCGGCAGCGT GCCCCACGAC TCTCAGGTGG CTGAAGGCCC CAGTGTGGAC 
ACCAGGCCCA AGAAGATGGA AAAAGAGCCT GCCGCCAGGG GGACCCCAGG AACGGGGAAG 
GAGAGGCTGA AAGCCGGAGC GAGCCCTCGG AGCGTCCCCG CGCGCAAGAA GGCGCAGACC 
GCGCCGCCCC TGCAGCCGCC GCCGCCGCCC CCGGCCCTGA GCGAGGAGCT GCCCTGGGGA 
GACCTGTCGC TCAACAAGTG CCTGGTGCTC GCCTCGCTGG TGGCGCTGCT GGGCTCGGCT 
TTCCAGCTGT GCCGCGGTGA GCGCAGGCTC CCCAGAGACG CCGTCCCTGG GGAGGCAGCA 
CTCCAAGCAC GTGTGCCCGA GCCCTGGGTC CCGCCAAGCT CAGCCCCGAG GGAGCCATCG 
TCGCCCCTGC CTAAGTTCGA GGCCCAGGCG CCTCCATCAG CGCCGCCTGC GCCCCGGGCC 
GAGGCAGAGG TCAGACCCAA GATTCCCGGG AGTCGGGAGG CTGCAGAGAA CGACGAAGAG 
GAGCCCGGCG AGGCCACCGG AGAGGCCGTC CGGGAGGACC GTGTGACCCT CGCAGACCGG 
GGACCCAAGG AGAGGCCTCG GAGAGAGGGG AAGCCGCGGA AGGAGAAGCC GCGGAAGGAG 
GAGAGACCTA AGAAAGAGAG GCCGCGGAAA GAGGAGAGGC CACGGGCCGC CAGGGAGCCC 
CGGGAAGCCC TACCCCAGCG CTGGGAGTCA CGCGAAGGGG GCCACCGGCC GTGGGCACGG 
GACTCCAGGG ACGCCGAGCC CAGGAAGAAG CAGGCCTGGG TGTCCCCGAG GCGTCCCGAC 
GAGGAGCAGC GGCCTGGGAG TCGCCAGAAG CTCCGCGCAG GCAAGGGGCG GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JSRP1 ( NM_144616.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_653217.1 Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), mRNA.

Price & Availability↑

CloneID	OHu17911
Clone ID Related Accession (Same CDS sequence)	NM_144616.4 , NM_144616.3
Accession Version	NM_144616.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	junctional sarcoplasmic reticulum protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA897543.1, DA898560.1, AK056978.1 and AW137573.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_144616.3. ##Evidence-Data-START## Transcript exon combination :: AK056978.1, SRR1163658.99742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300961.10/ ENSP00000300961.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCATGA CAACCAGAGC CTGGGAGGAG CTGGATGGCG GCCTGGGCAG CTGCCAGGCC 
CTGGAGGACC ACTCTGCGCT GGCCGAGACC CAGGAGGACA GGGCTTCAGC GACACCCAGG 
CTGGCCGACT CCGGCAGCGT GCCCCACGAC TCTCAGGTGG CTGAAGGCCC CAGTGTGGAC 
ACCAGGCCCA AGAAGATGGA AAAAGAGCCT GCCGCCAGGG GGACCCCAGG AACGGGGAAG 
GAGAGGCTGA AAGCCGGAGC GAGCCCTCGG AGCGTCCCCG CGCGCAAGAA GGCGCAGACC 
GCGCCGCCCC TGCAGCCGCC GCCGCCGCCC CCGGCCCTGA GCGAGGAGCT GCCCTGGGGA 
GACCTGTCGC TCAACAAGTG CCTGGTGCTC GCCTCGCTGG TGGCGCTGCT GGGCTCGGCT 
TTCCAGCTGT GCCGCGACGC CGTCCCTGGG GAGGCAGCAC TCCAAGCACG TGTGCCCGAG 
CCCTGGGTCC CGCCAAGCTC AGCCCCGAGG GAGCCATCGT CGCCCCTGCC TAAGTTCGAG 
GCCCAGGCGC CTCCATCAGC GCCGCCTGCG CCCCGGGCCG AGGCAGAGGT CAGACCCAAG 
ATTCCCGGGA GTCGGGAGGC TGCAGAGAAC GACGAAGAGG AGCCCGGCGA GGCCACCGGA 
GAGGCCGTCC GGGAGGACCG TGTGACCCTC GCAGACCGGG GACCCAAGGA GAGGCCTCGG 
AGAGAGGGGA AGCCGCGGAA GGAGAAGCCG CGGAAGGAGG AGAGACCTAA GAAAGAGAGG 
CCGCGGAAAG AGGAGAGGCC ACGGGCCGCC AGGGAGCCCC GGGAAGCCCT ACCCCAGCGC 
TGGGAGTCAC GCGAAGGGGG CCACCGGCCG TGGGCACGGG ACTCCAGGGA CGCCGAGCCC 
AGGAAGAAGC AGGCCTGGGT GTCCCCGAGG CGTCCCGACG AGGAGCAGCG GCCTGGGAGT 
CGCCAGAAGC TCCGCGCAGG CAAGGGGCGG GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653217.1
CDS	66..1061
Translation	MSMTTRAWEELDGGLGSCQALEDHSALAETQEDRASATPRLADSGSVPHDSQVAEGPSVDTRPKKMEKEPAARGTPGTGKERLKAGASPRSVPARKKAQTAPPLQPPPPPPALSEELPWGDLSLNKCLVLASLVALLGSAFQLCRDAVPGEAALQARVPEPWVPPSSAPREPSSPLPKFEAQAPPSAPPAPRAEAEVRPKIPGSREAAENDEEEPGEATGEAVREDRVTLADRGPKERPRREGKPRKEKPRKEERPKKERPRKEERPRAAREPREALPQRWESREGGHRPWARDSRDAEPRKKQAWVSPRRPDEEQRPGSRQKLRAGKGRD

Target ORF information:

RefSeq Version	NM_144616.4
Organism	Homo sapiens(human)
Definition	Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144616.4

ORF Insert Sequence:

ATGTCCATGA CAACCAGAGC CTGGGAGGAG CTGGATGGCG GCCTGGGCAG CTGCCAGGCC 
CTGGAGGACC ACTCTGCGCT GGCCGAGACC CAGGAGGACA GGGCTTCAGC GACACCCAGG 
CTGGCCGACT CCGGCAGCGT GCCCCACGAC TCTCAGGTGG CTGAAGGCCC CAGTGTGGAC 
ACCAGGCCCA AGAAGATGGA AAAAGAGCCT GCCGCCAGGG GGACCCCAGG AACGGGGAAG 
GAGAGGCTGA AAGCCGGAGC GAGCCCTCGG AGCGTCCCCG CGCGCAAGAA GGCGCAGACC 
GCGCCGCCCC TGCAGCCGCC GCCGCCGCCC CCGGCCCTGA GCGAGGAGCT GCCCTGGGGA 
GACCTGTCGC TCAACAAGTG CCTGGTGCTC GCCTCGCTGG TGGCGCTGCT GGGCTCGGCT 
TTCCAGCTGT GCCGCGACGC CGTCCCTGGG GAGGCAGCAC TCCAAGCACG TGTGCCCGAG 
CCCTGGGTCC CGCCAAGCTC AGCCCCGAGG GAGCCATCGT CGCCCCTGCC TAAGTTCGAG 
GCCCAGGCGC CTCCATCAGC GCCGCCTGCG CCCCGGGCCG AGGCAGAGGT CAGACCCAAG 
ATTCCCGGGA GTCGGGAGGC TGCAGAGAAC GACGAAGAGG AGCCCGGCGA GGCCACCGGA 
GAGGCCGTCC GGGAGGACCG TGTGACCCTC GCAGACCGGG GACCCAAGGA GAGGCCTCGG 
AGAGAGGGGA AGCCGCGGAA GGAGAAGCCG CGGAAGGAGG AGAGACCTAA GAAAGAGAGG 
CCGCGGAAAG AGGAGAGGCC ACGGGCCGCC AGGGAGCCCC GGGAAGCCCT ACCCCAGCGC 
TGGGAGTCAC GCGAAGGGGG CCACCGGCCG TGGGCACGGG ACTCCAGGGA CGCCGAGCCC 
AGGAAGAAGC AGGCCTGGGT GTCCCCGAGG CGTCCCGACG AGGAGCAGCG GCCTGGGAGT 
CGCCAGAAGC TCCGCGCAGG CAAGGGGCGG GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

JSRP1 ( NM_144616.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_653217.1 Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), mRNA.

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CloneID	OHu17911
Clone ID Related Accession (Same CDS sequence)	NM_144616.4 , NM_144616.3
Accession Version	NM_144616.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	junctional sarcoplasmic reticulum protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA897543.1, DA898560.1, AK056978.1 and AW137573.1. This sequence is a reference standard in the RefSeqGene project. On Mar 24, 2010 this sequence version replaced NM_144616.2. ##Evidence-Data-START## Transcript exon combination :: AK056978.1, SRR1163658.99742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCATGA CAACCAGAGC CTGGGAGGAG CTGGATGGCG GCCTGGGCAG CTGCCAGGCC 
CTGGAGGACC ACTCTGCGCT GGCCGAGACC CAGGAGGACA GGGCTTCAGC GACACCCAGG 
CTGGCCGACT CCGGCAGCGT GCCCCACGAC TCTCAGGTGG CTGAAGGCCC CAGTGTGGAC 
ACCAGGCCCA AGAAGATGGA AAAAGAGCCT GCCGCCAGGG GGACCCCAGG AACGGGGAAG 
GAGAGGCTGA AAGCCGGAGC GAGCCCTCGG AGCGTCCCCG CGCGCAAGAA GGCGCAGACC 
GCGCCGCCCC TGCAGCCGCC GCCGCCGCCC CCGGCCCTGA GCGAGGAGCT GCCCTGGGGA 
GACCTGTCGC TCAACAAGTG CCTGGTGCTC GCCTCGCTGG TGGCGCTGCT GGGCTCGGCT 
TTCCAGCTGT GCCGCGACGC CGTCCCTGGG GAGGCAGCAC TCCAAGCACG TGTGCCCGAG 
CCCTGGGTCC CGCCAAGCTC AGCCCCGAGG GAGCCATCGT CGCCCCTGCC TAAGTTCGAG 
GCCCAGGCGC CTCCATCAGC GCCGCCTGCG CCCCGGGCCG AGGCAGAGGT CAGACCCAAG 
ATTCCCGGGA GTCGGGAGGC TGCAGAGAAC GACGAAGAGG AGCCCGGCGA GGCCACCGGA 
GAGGCCGTCC GGGAGGACCG TGTGACCCTC GCAGACCGGG GACCCAAGGA GAGGCCTCGG 
AGAGAGGGGA AGCCGCGGAA GGAGAAGCCG CGGAAGGAGG AGAGACCTAA GAAAGAGAGG 
CCGCGGAAAG AGGAGAGGCC ACGGGCCGCC AGGGAGCCCC GGGAAGCCCT ACCCCAGCGC 
TGGGAGTCAC GCGAAGGGGG CCACCGGCCG TGGGCACGGG ACTCCAGGGA CGCCGAGCCC 
AGGAAGAAGC AGGCCTGGGT GTCCCCGAGG CGTCCCGACG AGGAGCAGCG GCCTGGGAGT 
CGCCAGAAGC TCCGCGCAGG CAAGGGGCGG GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653217.1
CDS	72..1067
Translation	MSMTTRAWEELDGGLGSCQALEDHSALAETQEDRASATPRLADSGSVPHDSQVAEGPSVDTRPKKMEKEPAARGTPGTGKERLKAGASPRSVPARKKAQTAPPLQPPPPPPALSEELPWGDLSLNKCLVLASLVALLGSAFQLCRDAVPGEAALQARVPEPWVPPSSAPREPSSPLPKFEAQAPPSAPPAPRAEAEVRPKIPGSREAAENDEEEPGEATGEAVREDRVTLADRGPKERPRREGKPRKEKPRKEERPKKERPRKEERPRAAREPREALPQRWESREGGHRPWARDSRDAEPRKKQAWVSPRRPDEEQRPGSRQKLRAGKGRD

Target ORF information:

RefSeq Version	NM_144616.3
Organism	Homo sapiens(human)
Definition	Homo sapiens junctional sarcoplasmic reticulum protein 1 (JSRP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144616.3

ORF Insert Sequence:

ATGTCCATGA CAACCAGAGC CTGGGAGGAG CTGGATGGCG GCCTGGGCAG CTGCCAGGCC 
CTGGAGGACC ACTCTGCGCT GGCCGAGACC CAGGAGGACA GGGCTTCAGC GACACCCAGG 
CTGGCCGACT CCGGCAGCGT GCCCCACGAC TCTCAGGTGG CTGAAGGCCC CAGTGTGGAC 
ACCAGGCCCA AGAAGATGGA AAAAGAGCCT GCCGCCAGGG GGACCCCAGG AACGGGGAAG 
GAGAGGCTGA AAGCCGGAGC GAGCCCTCGG AGCGTCCCCG CGCGCAAGAA GGCGCAGACC 
GCGCCGCCCC TGCAGCCGCC GCCGCCGCCC CCGGCCCTGA GCGAGGAGCT GCCCTGGGGA 
GACCTGTCGC TCAACAAGTG CCTGGTGCTC GCCTCGCTGG TGGCGCTGCT GGGCTCGGCT 
TTCCAGCTGT GCCGCGACGC CGTCCCTGGG GAGGCAGCAC TCCAAGCACG TGTGCCCGAG 
CCCTGGGTCC CGCCAAGCTC AGCCCCGAGG GAGCCATCGT CGCCCCTGCC TAAGTTCGAG 
GCCCAGGCGC CTCCATCAGC GCCGCCTGCG CCCCGGGCCG AGGCAGAGGT CAGACCCAAG 
ATTCCCGGGA GTCGGGAGGC TGCAGAGAAC GACGAAGAGG AGCCCGGCGA GGCCACCGGA 
GAGGCCGTCC GGGAGGACCG TGTGACCCTC GCAGACCGGG GACCCAAGGA GAGGCCTCGG 
AGAGAGGGGA AGCCGCGGAA GGAGAAGCCG CGGAAGGAGG AGAGACCTAA GAAAGAGAGG 
CCGCGGAAAG AGGAGAGGCC ACGGGCCGCC AGGGAGCCCC GGGAAGCCCT ACCCCAGCGC 
TGGGAGTCAC GCGAAGGGGG CCACCGGCCG TGGGCACGGG ACTCCAGGGA CGCCGAGCCC 
AGGAAGAAGC AGGCCTGGGT GTCCCCGAGG CGTCCCGACG AGGAGCAGCG GCCTGGGAGT 
CGCCAGAAGC TCCGCGCAGG CAAGGGGCGG GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

JP-45/JSRP1 variants affect skeletal muscle excitation-contraction coupling by decreasing the sensitivity of the dihydropyridine receptor.
Human mutation34(1)184-90(2013 Jan)
Yasuda T,Delbono O,Wang ZM,Messi ML,Girard T,Urwyler A,Treves S,Zorzato F

Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study.
European journal of human genetics : EJHG18(9)1021-6(2010 Sep)
Newby PR,Pickles OJ,Mazumdar S,Brand OJ,Carr-Smith JD,Pearce SH,Franklyn JA,,Evans DM,Simmonds MJ,Gough SC

A possible role of the junctional face protein JP-45 in modulating Ca2+ release in skeletal muscle.
The Journal of physiology572(Pt 1)269-80(2006 Apr)
Gouadon E,Schuhmeier RP,Ursu D,Anderson AA,Treves S,Zorzato F,Lehmann-Horn F,Melzer W

The novel skeletal muscle sarcoplasmic reticulum JP-45 protein. Molecular cloning, tissue distribution, developmental expression, and interaction with alpha 1.1 subunit of the voltage-gated calcium channel.
The Journal of biological chemistry278(41)39987-92(2003 Oct)
Anderson AA,Treves S,Biral D,Betto R,Sandonà D,Ronjat M,Zorzato F

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JSRP1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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