| Gene Symbol | GPHB5 |
| Entrez Gene ID | 122876 |
| Full Name | glycoprotein hormone beta 5 |
| Synonyms | B5,GPB5,ZLUT1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]. |
| Disorder MIM: |
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GPHB5 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following GPHB5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPHB5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu55827 Clone ID Related Accession (Same CDS sequence) NM_145171.3 , NM_145171.4 Accession Version NM_145171.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 393bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1550764800000 Organism Homo sapiens(human) Product glycoprotein hormone beta-5 precursor Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM709443.1. On Sep 13, 2011 this sequence version replaced NM_145171.2. ##Evidence-Data-START## Transcript exon combination :: BM709443.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END##
1
61
121
181
241
301
361ATGAAGCTGG CATTCCTCTT CCTTGGCCCC ATGGCCCTCC TCCTTCTGGC TGGCTATGGC
TGTGTCCTCG GTGCCTCCAG TGGGAACCTG CGCACCTTTG TGGGCTGTGC CGTGAGGGAG
TTTACTTTCC TGGCCAAGAA GCCAGGCTGC AGGGGCCTTC GGATCACCAC GGATGCCTGC
TGGGGTCGCT GTGAGACCTG GGAGAAACCC ATTCTGGAAC CCCCCTATAT TGAAGCCCAT
CATCGAGTCT GTACCTACAA CGAGACCAAA CAGGTGACTG TCAAGCTGCC CAACTGTGCC
CCGGGAGTCG ACCCCTTCTA CACCTATCCC GTGGCCATCC GCTGTGACTG CGGAGCCTGC
TCCACTGCCA CCACGGAGTG TGAGACCATC TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_660154.3 CDS 58..450 Translation 
Target ORF information:
RefSeq Version NM_145171.3 Organism Homo sapiens(human) Definition Homo sapiens glycoprotein hormone beta 5 (GPHB5), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_145171.3
ORF Insert Sequence:
1
61
121
181
241
301
361ATGAAGCTGG CATTCCTCTT CCTTGGCCCC ATGGCCCTCC TCCTTCTGGC TGGCTATGGC
TGTGTCCTCG GTGCCTCCAG TGGGAACCTG CGCACCTTTG TGGGCTGTGC CGTGAGGGAG
TTTACTTTCC TGGCCAAGAA GCCAGGCTGC AGGGGCCTTC GGATCACCAC GGATGCCTGC
TGGGGTCGCT GTGAGACCTG GGAGAAACCC ATTCTGGAAC CCCCCTATAT TGAAGCCCAT
CATCGAGTCT GTACCTACAA CGAGACCAAA CAGGTGACTG TCAAGCTGCC CAACTGTGCC
CCGGGAGTCG ACCCCTTCTA CACCTATCCC GTGGCCATCC GCTGTGACTG CGGAGCCTGC
TCCACTGCCA CCACGGAGTG TGAGACCATC TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu55827 Clone ID Related Accession (Same CDS sequence) NM_145171.3 , NM_145171.4 Accession Version NM_145171.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 393bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1571500800000 Organism Homo sapiens(human) Product glycoprotein hormone beta-5 precursor Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL118555.6 and BM709443.1. On May 17, 2019 this sequence version replaced NM_145171.3. ##Evidence-Data-START## Transcript exon combination :: BM709443.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000621500.2/ ENSP00000478993.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
1
61
121
181
241
301
361ATGAAGCTGG CATTCCTCTT CCTTGGCCCC ATGGCCCTCC TCCTTCTGGC TGGCTATGGC
TGTGTCCTCG GTGCCTCCAG TGGGAACCTG CGCACCTTTG TGGGCTGTGC CGTGAGGGAG
TTTACTTTCC TGGCCAAGAA GCCAGGCTGC AGGGGCCTTC GGATCACCAC GGATGCCTGC
TGGGGTCGCT GTGAGACCTG GGAGAAACCC ATTCTGGAAC CCCCCTATAT TGAAGCCCAT
CATCGAGTCT GTACCTACAA CGAGACCAAA CAGGTGACTG TCAAGCTGCC CAACTGTGCC
CCGGGAGTCG ACCCCTTCTA CACCTATCCC GTGGCCATCC GCTGTGACTG CGGAGCCTGC
TCCACTGCCA CCACGGAGTG TGAGACCATC TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_660154.3 CDS 114..506 Translation
Target ORF information:
RefSeq Version NM_145171.4 Organism Homo sapiens(human) Definition Homo sapiens glycoprotein hormone subunit beta 5 (GPHB5), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_145171.4
ORF Insert Sequence:
1
61
121
181
241
301
361ATGAAGCTGG CATTCCTCTT CCTTGGCCCC ATGGCCCTCC TCCTTCTGGC TGGCTATGGC
TGTGTCCTCG GTGCCTCCAG TGGGAACCTG CGCACCTTTG TGGGCTGTGC CGTGAGGGAG
TTTACTTTCC TGGCCAAGAA GCCAGGCTGC AGGGGCCTTC GGATCACCAC GGATGCCTGC
TGGGGTCGCT GTGAGACCTG GGAGAAACCC ATTCTGGAAC CCCCCTATAT TGAAGCCCAT
CATCGAGTCT GTACCTACAA CGAGACCAAA CAGGTGACTG TCAAGCTGCC CAACTGTGCC
CCGGGAGTCG ACCCCTTCTA CACCTATCCC GTGGCCATCC GCTGTGACTG CGGAGCCTGC
TCCACTGCCA CCACGGAGTG TGAGACCATC TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Inflammatory cytokines regulate glycoprotein subunit beta5 of thyrostimulin through nuclear factor-kappaB.
Endocrinology150(5)2237-43(2009 May)
Suzuki C,Nagasaki H,Okajima Y,Suga H,Ozaki N,Arima H,Iwasaki Y,Oiso Y
Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5).
Regulatory peptides148(1-3)62-7(2008 Jun)
Okajima Y,Nagasaki H,Suzuki C,Suga H,Ozaki N,Arima H,Hamada Y,Civelli O,Oiso Y
A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor.
Molecular endocrinology (Baltimore, Md.)20(2)414-25(2006 Feb)
Okada SL,Ellsworth JL,Durnam DM,Haugen HS,Holloway JL,Kelley ML,Lewis KE,Ren H,Sheppard PO,Storey HM,Waggie KS,Wolf AC,Yao LY,Webster PJ
Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5.
Endocrinology146(8)3596-604(2005 Aug)
Sudo S,Kuwabara Y,Park JI,Hsu SY,Hsueh AJ
The DNA sequence and analysis of human chromosome 14.
Nature421(6923)601-7(2003 Feb)
Heilig R,Eckenberg R,Petit JL,Fonknechten N,Da Silva C,Cattolico L,Levy M,Barbe V,de Berardinis V,Ureta-Vidal A,Pelletier E,Vico V,Anthouard V,Rowen L,Madan A,Qin S,Sun H,Du H,Pepin K,Artiguenave F,Robert C,Cruaud C,Brüls T,Jaillon O,Friedlander L,Samson G,Brottier P,Cure S,Ségurens B,Anière F,Samain S,Crespeau H,Abbasi N,Aiach N,Boscus D,Dickhoff R,Dors M,Dubois I,Friedman C,Gouyvenoux M,James R,Madan A,Mairey-Estrada B,Mangenot S,Martins N,Ménard M,Oztas S,Ratcliffe A,Shaffer T,Trask B,Vacherie B,Bellemere C,Belser C,Besnard-Gonnet M,Bartol-Mavel D,Boutard M,Briez-Silla S,Combette S,Dufossé-Laurent V,Ferron C,Lechaplais C,Louesse C,Muselet D,Magdelenat G,Pateau E,Petit E,Sirvain-Trukniewicz P,Trybou A,Vega-Czarny N,Bataille E,Bluet E,Bordelais I,Dubois M,Dumont C,Guérin T,Haffray S,Hammadi R,Muanga J,Pellouin V,Robert D,Wunderle E,Gauguet G,Roy A,Sainte-Marthe L,Verdier J,Verdier-Discala C,Hillier L,Fulton L,McPherson J,Matsuda F,Wilson R,Scarpelli C,Gyapay G,Wincker P,Saurin W,Quétier F,Waterston R,Hood L,Weissenbach J
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